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JOURNAL OF VIROLOGYVOLUME 48 NUMBER 3 DECEMBER 1983
Edward M. Scolnick, Editor in Chief (1987)Merck Sharp & Dolime Research Laboraitories
Wes.t Point, Pa.David T. Denhardt, Editor (1987)University of Western OntarioLondon, Ontario, Canada
Bernard N. Fields, Editor (1988)Harvard University, Medical School
Boston, Mass.
Harold S. Ginsberg, Editor (1984)Coluimbia UniversityNew York, N.Y.
Robert M. Krug, Editor (1987)Sloan-Kettering Institute
New York, N.Y.Michael B. A. Oldstone, Editor (1988)Sc ripps Clinic & Research Fouindation
La Jolla, Calif.
Robert A. Weisberg, Editor (1988)National Institlute of Child Health and Human Development
Bethesda, Md.
David Baltimore (1984)Amiya K. Banerjee (1985)Andrew Becker (1985)Tamar Ben-Porat (1984)Kenneth I. Berns (1985)David Botstein (1985)Dennis T. Brown (1984)Ahmad I. Bukhari (1984)Barrie J. Carter (1984)Purnell Choppin (1983)John M. Coffin (1983)Geoffrey M. Cooper (1984)Walter Doerfler (1983)Harrison Echols (1984)Elvera Ehrenfeld (1983)Robert N. Eisenman (1985)Suzanne U. Emerson (1983)S. Jane Flint (1984)Yasuhiro Furuichi (1985)Costa Georgopolous (1983)Larry M. Gold (1985)Peter Gruss (1985)Hidesaburo Hanafusa (1983)William S. Hayward (1984)John J. Holland (1984)Ian H. Holmes (1983)Robert W. Honess (1983)Nancy Hopkins (1983)Peter M. Howley (1984)
EDITORIAL BOARDAlice S. Huang (1984)Tony Hunter (1983)Masayori Inouye (1985)Robert Kamen (1985)Thomas J. Kelly, Jr. (1985)George Khoury (1984)Elliott Kieff (1984)Jonathan A. King (1984)Daniel Kolakofsky (1983)Robert Lamb (1985)Robert A. Lazzarini (1984)Myron Levine (1985)Douglas R. Lowy (1983)Robert Martin (1984)George Miller (1984)Lois K. Miller (1985)Robert C. Miller (1983)Peter Model (1983)Bernard Moss (1983)Nancy G. Nossal (1984)J. Thomas Parsons (1983)Ulf G. Petterson (1983)Lennart Philipson (1984)Lewis I. Pizer (1984)Craig R. Pringle (1983)Fred Rapp (1984)Dan S. Ray (1983)M. E. Reichmann (1985)Gordon M. Ringold (1984)
Harriet Robinson (1985)William S. Robinson (1983)Bernard Roizman (1985)Roland R. Rueckert (1985)Norman P. Salzman (1984)Joseph Sambrook (1985)Priscilla A. Schaffer (1984)Sondra Schlesinger (1983)June R. Scott (1983)Bart Sefton (1985)Phillip A. Sharp (1985)Thomas E. Shenk (1984)Charles J. Sherr (1984)Saul J. Silverstein (1985)Lee D. Simon (1984)Ann Skalka (1985)Patricia G. Spear (1984)Mark F. Stinski (1983)F. William Studier (1984)Lawrence S. Sturman (1985)Jesse Summers (1985)William Summers (1985)John M. Taylor (1984)Howard M. Temin (1985)George F. Vande Woude (1983)Edward K. Wagner (1983)Eckard Wimmer (1985)Charles Hamish Young (1983)
Helen R. Whiteley, Chairman, Publications BoacrdLinda M. Illig, Managing Editor, Jouirnals
Walter G. Peter III, Direc tor, PublicationsPaula R. Ellison, Production Editor
The Journal of Virology (ISSN 0022-538X), a publication of the American Society for Microbiology, 1913 1 St., NW.Washington, DC 20006, is devoted to the dissemination of fundamental knowledge concerning viruses of bacteria, plants, andanimals. Investigators are invited to submit reports of original research in all areas of basic virology, including biochemistry.biophysics, genetics, immunology, morphology, physiology, and pathogenesis and immunity. Instructions to authors arepublished in the January issue each year; reprints are available from the editors and the Publications Office. The Jollrnlal is issuedmonthly, four volumes per year. The nonmember subscription price is $225 per year; single copies are $20. The membersubscription price is $37 (foreign, $44 [surface ratel) per year; single copies are $7.00. Correspondence relating to subscriptions,reprints, defective copies, availability of back issues, lost or late proofs. disposition of submitted manuscripts, and generaleditorial matters should be directed to the ASM Publications Office, 1913 I St., NW, Washington, DC 20006 (area 202 833-9680).
Claims for missing issues from residents of the United States, Canada, and Mexico must be submitted within 3 months afterpublication of the issues; residents of all other countries must submit claims within 6 months of publication of the issues. Claimsfor issues missing because of failure to report an address change or for issues 'missing from files" will not be allowed.
Second-class postage paid at Washington, DC 20006, and at additional mailing offices.POSTMASTER: Send address changes to Jouirnal of Virology, ASM, 1913 I St., NW, Washington. DC 20006.Made in the U.S.A.Copyright © 1983, American Society for Microbiology. (*fdli(f4P(Jt .kJ L1'.JI' ( I'1I.tAll Rights Reserved.
The code at the top of the first page of an article in this journal indicates the copyright owner's consent that copies of the articlemay be made for personal use or for personal use of specific clients. This consent is given on the condition. however, that thecopier pay the stated per-copy fee through the Copyright Clearance Center. 21 Congress St., Salem. MA 01970. for copyingbeyond that permitted by Sections 107 and 108 of the U.S. Copyright Law. This consent does not extend to other kinds ofcopying, such as copying for general distribution, for advertising or promotional purposes, for creating new collective works, orfor resale.
Author Index
Aasted, Bent, 573Andersen, Klaus B., 765Appella, Ettore, 709
Banks, L., 591Baric, Ralph S., 633Barker, Peter E., 770Bishop, J. Michael, 565Bloom, Marshall E., 573Boone, Lawrence R., 779Bornkamm, G. W., 731Brackmann, Karl H., 604Brewer, Gregory J., 774Buekens, Pierre, 697
Cogniaux-LeClerc, Jacqueline, 697Cohen, G., 591Cooper, Jonathan A., 752Costa, R. H., 591Cywinski, Anita, 654
Dalianis, Tina, 709DesGroseillers, Luc, 685Draper, K. G., 591
Eisenberg, R., 591
Foster, David A., 744Freese, U. K., 731Fuchs, L. Yolanda, 641
Garcia, Ernesto, 721Garon, Claude F., 573Ghisotti, Daniela, 616G6mez, Antonio, 721Goto, Ronald M., 774Green, Maurice, 604
Hamagishi, Yasutaro, 709Hanafusa, Hidesaburo, 744Henry, Berch, II, 580Hood, Rachel, 580Hudewentz, J., 731Hughes, Stephen H., 667Hunter, Tony, 752
Ito, Yoshiaki, 709
Jolicoeur, Paul, 685
Kahlon, Jasbir, 627Klempnauer, Karl-Heinz, 565Koh, Chong-kun, 779Koprowski, Hilary, 660Kramer, Tammo A., 604
Lai, Michael M. C., 633Laux, G., 731Lee, Donald, 647Levis, Robin, 676L6pez, Rubens, 721Lucher, Lynne A., 604
Mayer, Leonard W., 573
Olislager, Roland, 697Ou, Chin-yih, 779Ozanne, Brad, 752
Pagano, Joseph S., 580Powell, K. L., 591
Raab-Traub, Nancy, 580Reagan, Kevin J., 660
Ricci, William, 667Ronda, Concepci6n, 721Roussel, Martine F., 770Roy, Polly, 627Ruddle, Frank H., 770
Sadowski, Paul D., 647Schlesinger, Sondra, 676Schwarz, E., 731Scolnick, Edward M., 752Segawa, Kaoru, 709Sherr, Charles J., 770Sironi, Gianpiero, 616Smith, Julie K., 654Sorge, Joe, 667Sprecher-Goldberger, Suzanne,697
Stohlman, Stephen A., 633Sugiyama, Kazuo, 627Symington, Janey S., 604
Taylor, John M., 654Tennant, Raymond W., 779Thiry, Lise, 697
Wagner, E. K., 591Weaver, Robert F., 641Weiss, Barbara, 676Wiktor, Tadeusz J., 660Willingham, Mark, 709Woods, Michael S., 641Wunner, William H., 660
Yang, Czau-Siung, 580Yang, Wen K., 779
Zangrossi, Sandro, 616
ACKNOWLEDGMENT
The following have served as invited special reviewers for the Journal during 1983, and their helpis greatly appreciated.
Stu AaronsonSankar AdhyaRafi AhmedCharles A. Alford, Jr.James AlwineRobert AndersonSteven AndersonRalph ArlinghausRichard ArmentroutRichard AxelHoward L. BachrachJohn BaderGeorge BaerCorrado BaglioniL. Andrew BallMarcel BaludaMariano BarbacidJ. Richard BaringerSamuel BaronRenato BasergaClaudio BasilicoRobert BassinKaren BeemanThomas BenjaminArnold BerkAnna BialkowskaDavid BishopMichael BishopKlaus BisterDonald BlairBarry BloomMarshall E. BloomDavid BoettingerDani BolognesiMichael BotchanPierre BourgauxJoan BruggeMichael BuchmeierSteven BurakoffHoward BusseyJanet ButelBruce CalnekRobert B. CarrollEric B. CarstensSherwood CasjensEsther ChangRobert ChanockLan Bo ChenCraig CohenGary H. CohenCharles ColePhilip ColemanRichard ColonnoRichard W. CompansJon CondraLouis Z. CooperRichard J. CourtneyRichard L. CrowellClyde Crumpacker
Diane CuppelsSamuel DalesVittorio DefendiMel DePamphilisRavi DharJules L. DienstagDan DimaioGeorge DimayorcaDino DinaMartin E. DorfR. Gordon DouglasWalter DowdleGordon DreesmanGideon DreyfusPeter DuesbergWalter EckhartJohn ElderRon EllisFrancis A. EnnisLynne EnquistMarcia J. EnsingerLois B. EpsteinH. Gunti ErdlRaymond EriksonMax EssexMary Kolb EstesAnthony S. FauciGerald FinkJames B. FlaneganErwin FleissnerStephen C. FosterMichael M. FrankRobert FriedmanTed FriedmanMark FurthRobert GalloAnthony GarroE. Peter GeidushekWalter GerhardJohn L. GerinAnne A. GershonMary Jane GethingRaymond GildenW. Paul GlezonLaurie GlimcherYosha GluzmanNigel GodsonSteve GoffAngus GrahamFrank L. GrahamHarry B. GreenbergMark I. GreeneTerry GrodzigerCharles F. GroseAshley T. HaaseMary HaffeyGordon HagerJules HallumScott B. Halstead
Berg HamparDaniel HardyJanet HartleyWilliam HaseltineJohn HassellStanley HattmanAnne M. HaywoodAri HeleniusRoger HendrixRoger HewittLawrence HightowerMaurice R. HillemanShalom Z. HirschmanMonto HoJohn J. HollandF. Blaine HollingerJohn A. HolowczakMarshall HorwitzSally HuberJoe HughesJerry HurwitzRichard HymanJames N. IhleMark IsraelYoshiaki ItoGilbert JayRichard T. JohnsonWolfgang JoklikDavid KabatAlbert KapikianRobert S. KauffmanVicki E. KelleyD. C. KellyEli KeshetEdwin D. KilbourneSaul KitDavid KnipeChristine KozakD. H. KrugerEdward KuffMichael LaiRonald A. LaskeyPaul LebowitzPhillip LederStanley S. LefkowitzRobert I. LehrerJohn LenardPeter LengyelArnold J. LevineMichael LevineArt LevinsonMichael LiebowitzFrank LillyTomas LindahlDavid LinemeyerMaxine LinialDavid LivingstonHarvey LodishCarlos Lopez
J. Lucas-LenardGeorge MackieTak MakKirstine MannEleftheria Maratos-FlierDante MarcianiPhilip MarcusStuart MarcusMalcolm MartinPhilip E. McAllisterWilliam McClementsDonald McCorquodaleDale McFarlinTravis C. McGuire, Jr.Kenneth McIntoshRoger McMackenDonald N. Medearis, Jr.Pamela MellonJoseph MelnickThomas C. Merigan, Jr.Barry 1. MilavetzThomas P. MonathJohn MoorheadGisela MosigRichard MoxonBrian MurphyRobert MurrayA. J. NahmiasOpendra NarayanDan NathansNeal NathensonPaul E. NeimanAbner L. NotkinsJohn F. ObijeskiPaul O'DonnellLloyd OldAllen OliffSteve OroszlanJune E. OsbornMichael N. OxmanJoseph PaganoPeter PaleseEnzo PaolettiWade ParksRobert H. ParrottJames PenningtonJanice PeroSidney PestkaBruce A. PhillipsPaula PithaBernard PoieszRobert Pollack
David PorterPoteeteKenneth L. PowellCarol PrivesRobert PurcellPaul G. QuieCharles RaddingCedric RaineR. Frank RamigSaraiya RasheedWilliam RawlsAlan ReinJack S. RemingtonRoberta ReubenMarkus RhoadesSolon Rhode IIIMark RiemenWilliam S. RobinsonGeorge RohrmannJohn RoseMartin RosenbergNaomi RosenbergLanny J. RosenwasserBarry RouseMartine RousselWallace RoweFrank RuddleKathleen RundellSandra RuscettiPhilip K. RussellMartin RutaPaul SadowskiCharles E. SamuelAndreas S. ScheidR. Walter SchlesingerStuart F. SchlossmanLoren SchultzRobert S. SchwartzArup SenGanes SenJohn L. SeverDavid ShafritzArlene SharpeAaron J. ShatkinRobert E. ShopeSteven L. ShoreMaxine SingerN. K. SinhaLarry SnyderDennis StaceyJack StevensWilliam E. Stewart 11
Bruce W. StillmanSteven E. StrausJames StraussJack L. StromingerMax D. SummersStanley TaharaKenneth TakemotoIgor TammPeter J. TattersallPeter TegtmeyerGretchen TemelesIrwin TessmanMary J. R. TevethiaSatvir TevethiaRobert ThachDennis TrentStephen UdemBernard van der JeistJames Van EttenHarold VarmusLeland F. VelicerInder VermaJan T. VilcekPeter VogtRobert WagnerDuard L. WalkerJack WandsJoseph WeberMichael WeberSteven L. WechslerRobert WeinbergHoward WeinerLeslie P. WeinerDavid WeinsteinRobin WeissSusan WeissSherman WeissmanRaymond M. Welsh, Jr.Reed WicknerJim WilliamsOwen WitteLinda WolffH. A. WoodWilliam WunnerRichard WyattKeith YamamotoRobert H. YolkenFaith YoshimuraHoward YoungJulius YoungnerStuart YuspaHans J. Zweerink
INDEX TO DATE OF ISSUE
Date of Issue
20 September 198321 October 198317 November 1983
U.S. rstlS-ric.
STATEMENT OF OWNERSHIP MANAGEMENT AND CIRCULATIONROIFieJ by 39 US C 3683)
TITlE OF PugLICATION 1B. PUBLICATION NO. 2 DATE OF FILING
Journal of Virology 30 September 19833FROENeO ISSUE 3 OO SUSPBIHD3 NULSBCITO
ANNUALI Y PRICE
Mootthly 12 $37 mbr, 0225 nonmbr"COMPLETE MAILING ADDRESS OF KNOWN OFFICE OF PUBLICATION (S010e,. CY,y. CFuFy. SOFFOFFd ZFPCodOF INOFpriFtrtJ
1913 I Street, N.W., Washington, D.C. 200065 COMPLETE MAILING ADDRESS OF THE HEADOUARTERS OF GENERAL BUSINESS OFFICES OF THE PUBLISHER INtFopSFFO)
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American Society for Microbiology, 1913 1 Street, N.W., Washington, D.C. 20006EDITOR (NF-F FdCo-pFMF011Add-Fs
Director of PublicationsWalter G. Peter III, 1913 I Street, N.W., Washington, D.C. 20006
MANAGING EDITOR CN--OFend C-pl-r MFIIFF. Addr,-)F
Walter G. Peter III, same as above7 OWNER t1f-wnd bvevprno se nddrsmtb, Jt,td..d.hom itttudrhnmwnedrJ.osoki0- hWldIf Z DI ntor-oF. o Fo FF0F0FFo k FFFFFov FFFdbyeF-F p -rh.0t 8h ,0 Fnd.dd-10138oth0Fi.dOid..lovFF F nrOFbFl.hO d b, ef CnofiF FF,.IRFFFFIFOFOFFFFed eddr rt -0ub .,ld m-uFb0omFpl,Id
r _ XX ~~~~FULL NAME |COMPLETE MAILING ADDRESSnerican Sogiety1FFTioooblology 11913 I Street, N.W., WasTiingTont .C 00U
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FOR COMPLETION BY NONPROFIT ORGANIZATIONSAUTHORIZEDO F MAIL AT SPECIAL RATES 1S00i.F.23 12DMM.oyI|hups,f---io, nd noProfil wt.u of 1h,, .ryg-4.0. *nd th. ...-pt wt.tu f.r F.d- incme.o sUp-p-r Ch-kt -n.1
AUTHOR INDEX
VOLUME 48
Aasted, Bent, 573Aboud, Mordechai, 120Ahola, Harri, 370Akusjarvi, G., 127Anders, David G., 197, 206Andersen, Klaus B., 765Anderson, Carl W., 31Appella, Ettore, 709Ariga, Hiroyoshi, 481Arnold, Georg, 157Atkinson, Paul H., 335
Bachi, Thomas, 239Banks, L., 591Baric, Ralph S., 633Barker, Peter E., 770Barnett, Jim W., 384Barrett, Kathleen J., 157Bates, Robert C., 10Bellamy, A. Richard, 335Betz, Joan L., 460Bishop, J. Michael, 565Bister, Klaus, 61Blanck, George, 492Bleumink, Nancy, 249, 262Blinkova, Aleksandra, 157Blissard, Gary W., 74Bloom, Marshall E., 573Boccara, Martine, 102Bodemer, Walter, 377Boeye, Albert, 309Boone, Lawrence R., 110, 779Bornkamm, G. W., 731Both, Gerald W., 52, 335Brackmann, Karl H., 604Bratt, Michael A., 440Brewer, Gregory J., 774Brugge, Joan S., 352Brzustowicz, Linda, 555Buekens, Pierre, 697Burke, Julian F., 304
Campadelli-Fiume, Gabriella, 325Campbell, Bruce A., 561Carlson, Karin, 18Carter, Barrie J., 79Chambraud, B., 127Chan, Hardy W., 384Chen, Suzie, 492Cheung, Andrew, 451Chowdhury, Kamal, 40Cogniaux-LeClerc, Jacqueline, 697Cohen, G., 591Cohen, Gary H., 521Collett, Marc S., 320Collins, Lisa, 542Consigli, Richard A., 197, 206Cooper, Jonathan A., 752
Cords, Carl E., 561Costa, R. H., 591Costanzo, Franco, 325Costanzo, Maria, 555Cox, Nancy J., 52Crawford, Lionel V., 262Cywinski, Anita, 654
Dalianis, Tina, 709Dall'Olio, Fabio, 325Dasgupta, Asim, 429DeLamarter, John, 451DePamphilis, Melvin L., 281DesGroseillers, Luc, 685Dietrich, Walter, 377Dorsett, Dale L., 218Draper, K. G., 591Dunn, John J., 31Dyall-Smith, Michael L., 330
Eisenberg, R., 591Eisenberg, Roselyn J., 521Emini, Emilio A., 547Ensinger, Marcia J., 419Eppstein, Deborah A., 384Evans, Mary Jo, 304
Favre, Michel, 340Feitelson, Mark A., 534Fleckenstein, Bernhard, 377Fleissner, Erwin, 102Fleming, Jo-Ann G. W., 74Folk, William R., 472Foster, David A., 744Freese, U. K., 731Fuchs, L. Yolanda, 641
Ganem, Don, 1Garcfa, Ernesto, 721Garon, Claude F., 40, 573Gerhard, Walter, 239Ghisotti, Daniela, 616Ghosh, Prabhat K., 503Gibson, Marylou G., 396Gilardi, P., 127G6mez, Antonio, 721Goto, Ronald M., 774Graessmann, A., 296Graessmann, M., 2%Grass, David S., 492Green, Maurice, 604Grinnell, Brian W., 88
Hamagishi, Yasutaro, 709Hanafusa, Hidesaburo, 744Hannett, Nancy, 555
Hardy, Medora M., 31Hayashi, Marie N., 186Hayashi, Masaki, 186Hayward, S. Diane, 135Henderson, Louis E., 314Henry, Berch, II, 580Hoganson, Neal, 492Holmes, Ian H., 330Hood, Rachel, 580Horzinek, Marian C., 249Huberman, Joel A., 304Hudewentz, J., 731Hughes, Stephen H., 667Huleihel, Mahmoud, 120Hunter, Tony, 752
Ikura, Koji, 460Iorio, Ronald M., 440Israel, Mark A., 40Ito, Yoshiaki, 709
Jablonska, Stefania, 340Jansen, Hans W., 61Jeang, Kuan-Teh, 135Jentoft, J., 361Jolicoeur, Paul, 685
Kahlon, Jasbir, 627Kantharidis, Phillip, 330Kendal, Alan P., 52Keshet, Ilana, 218, 229Klempnauer, Karl-Heinz, 565Klessig, Daniel F., 31Knight, Susan S., 534Knust, Elisabeth, 377Koh, Chong K., 110Koh, Chong-kun, 779Koprowski, Hilary, 660Kozak, Christine A., 300Kramer, Tammo A., 604Kremsdorf, Dina, 340Kupper, Hans, 451
Lai, Michael M. C., 633Larson, Ruby, 320Laub, Orgad, 271Laux, G., 731Lavie, Vered, 229Lederman, Muriel, 10Lee, Donald, 647Leis, J., 361Le Moullec, J. M., 127Levis, Robin, 676Lewis, Anita J., 352Lipsich, Leah A., 352Lomax, Nancy B., 410
i
ii AUTHOR INDEX
L6pez, Rubens, 721Lucher, Lynne A., 604
Magarian, Claudette, 102Manley, James L., 492Marcus-Sekura, Carol J., 79Margolskee, Robert F., 405Marion, Patricia L., 534Matthews, James T., 521Mayer, Leonard W., 573McBeth, Dani L., 149McKinney, Martin D., 551Mirault, Marc-Edouard, 249Mirenda, Carol, 542Moreno-Lopez, Jorge, 370Morrow, Casey D., 429Muller, Uwe R., 170, 180, 186Myer, Fred E., 110
Nasri, M., 127Nathans, Daniel, 405Norkin, Leonard C., 503Noyes, Barbara E., 249
Oliff, Allen, 542Olislager, Roland, 697Oroszlan, Stephen, 314Orth, Gerard, 340Oshiro, Lyndon S., 534Ostapchuk, Philomena, 547Osterhaus, Albert D. M. E., 249Ou, Chin-Yih, 110Ou, Chin-yih, 779Ozanne, Brad, 752
Pagano, Joseph S., 580Parker, Barbara, 249Patschinsky, Tilo, 61Pero, Janice, 555Perricaudet, M., 127Pettersson, U., 127Pettersson, Ulf, 370Piatak, Michael, 503Pizer, Lewis I., 460Plummer, M. Joan, 304Pollack, Robert E., 492
Powell, K. L., 591Purchio, A. F., 320
Raab-Traub, Nancy, 580Rall, Leslie B., 271Reagan, Kevin J., 660Ricci, William, 667Roberson, Laurence E., 110Robinson, William S., 534Romantschuk, Martin L., 180Ronda, Concepci6n, 721Rothwell, Victoria M., 472Roussel, Martine F., 770Rovinsky, Michael, 419Roy, Polly, 627Ruddle, Frank H., 770Rutter, William J., 271
Sadler, John R., 460Sadowski, Paul D., 647Scannavini, Maurizia, 325Schlesinger, Sondra, 676Schwarz, E., 731Scolnick, Edward M., 752Seeger, Christoph, 1Segawa, Kaoru, 709Serafini-Cessi, Franca, 325Shaul, Yosef, 271Sherr, Charles J., 770Siegman, Linda J., 335Sironi, Gianpiero, 616Sleigh, Merilyn J., 52Smith, Julie K., 654Smythers, Gary, 314Sorge, Joe, 667Souyri, Michele, 102Sowder, Raymond, 314Spear, Patricia G., 396Sprecher-Goldberger, Suzanne,697
Stalhandske, P., 127Standring, David N., 271Stark, George R., 249, 262Stavnezer, Edward, 102Stenlund, Arne, 370Stohlman, Stephen A., 633Stout, Ernest R., 10Sugano, Sumio, 481
Sugiyama, Kazuo, 627Summers, Max D., 74Swyryd, Elizabeth A., 249, 262Symington, Janey S., 604
Tack, Lois C., 281Taylor, Austin L., 149Taylor, John M., 654Tennant, Raymond W., 110, 779Thiry, Lise, 697Thomas, Adri A. M., 309Truett, Martha, 271Tsubota, Yoriaki, 304
Valenzuela, Pablo, 271van der Zeijst, Bernard A. M.,
249, 262Varmus, Harold E., 1Vinson, S. Bradleigh, 74Voorma, Harry O., 309
Wagner, E. K., 591Wagner, Robert R., 88Waqar, M. Anwar, 304Weaver, Robert F., 641Wechsler, James A., 551Weiser, Barbara, 1Weiss, Barbara, 676Weiss, Stephen, 451Weissman, Sherman M., 503Westphal, H., 2%Wiberg, John S., 18Wiktor, Tadeusz J., 660Willingham, Mark, 709Wimmer, Eckard, 547Winocour, Ernest, 218, 229Woods, Michael S., 641Wunner, William H., 660
Yang, Czau-Siung, 580Yang, D. M., 110Yang, Wen K., 110, 779Yewdell, Jonathan W., 239Yin, Fay H., 410
Zangrossi, Sandro, 616
J. VIROL.
SUBJECT INDEX
VOLUME 48
Adeno-associated viruschromatin-like structure of DNA, 79
Adenovirustype 2DNA-binding protein gene, 31independent, spontaneous mutants, 31major late transcription unit, 127monkey cells, 31polyadenylic acid addition sites, 127simian virus 40 hybrid, 31
Aleutian disease virusantigen expressionrecombinant plasmid, 573
molecular cloning, 573recombinant plasmid
antigen expression, 573Antibody
anti-idiotypicrabies virus glycoprotein, 660
antipeptidehuman adenovirus 2 ElB-19K tumor antigen, 604human adenovirus 2 ElB-53K tumor antigen, 604
monoclonalanti-hemagglutinin, 239avian sarcoma virus transforming proteins, 352baboon endogenous virus cell receptors, 697group B coxsackieviruses, 561influenza virus A/PR/834, 239inhibition of virus attachment, 561irreversible antigenic alterations, 239Newcastle disease virus, 440
neutralizingrabies virus glycoprotein, 660
nonapeptide, 709poliovirus
bivalent attachment, 547conformational alteration and neutralization, 547genome-linked protein VPg, 429NH2 terminus, 429synthetic nonapeptide, 429
polyomavirus, 709Antigen
Aleutian disease virusrecombinant plasmid, 573
middle Tnonapeptide, 709polyomavirus, 709
super Tsimian virus 40, 492transformed mouse cells, 492
surfaceduck hepatitis B virus, 534hepatitis B virus, 271major polypeptide, 534synthesis in mammalian cells, 271
Tearly replicating DNA intermediates, 281simian virus 40 chromosome complexes, 281
tumorantipeptide antibodies, 604human adenovirus 2 EIB-19K, 604human adenovirus 2 ElB-53K, 604
4utographa californicanuclear polyhedrosis virus
novel RNA polymerase, 641S. frugiperda cells, 641viral transcription, 641
Avian myeloblastosis virusc-myb transduction
cellular gene, 565points of recombination, 565
Avian oncovirusMH2
molecular cloning of proviral DNA, 61structural analysis of viral RNA and protein, 61
Avian retrovirusDNA discontinuities, 654ppl2 protein
interaction with viral RNA, 361Avian sarcoma virusmonoclonal antibodies
transforming proteins, 352transforming proteinsmonoclonal antibodies, 352
Baboon endogenous viruscell receptorsmonoclonal antibodies, 697
monoclonal antibodiescell receptors, 697
BacteriophageCp-l
protease-sensitive transfection of S. pneumoniae,721
G4DNA secondary structure modifications, 170enzymatic construction and selection of mutants,
170gene expression, 180J-F intercistronic region, 170, 180, 186mRNA stability, 186mutations, 180
lambdadnaB protein, 551P protein, 551replication, 551RNA polymerase interaction, 551
MuE. coli K-12 DNA polymerase I, 149growth, 149
P4a gene, 157RNA polymerase, 157
P2-xinterference by E. coli, 616
4X174gene expression, 180J-F intercistronic region, 180, 186mRNA stability, 186mutations, 180simian virus 40 recombinant genomes, 229
PM2gram-negative host, 774
iii
iv SUBJECT INDEX
phosphatidylethanolamine accessibility, 774SPO1gene 27, 555
T4cytosine, 18in vivo cleavage, 18
T7direct physical assay, 647in vitro DNA recombination, 647
BHK cellslymphocytic choriomeningitis virus
persistent infection, 262RNAs, 262viral proteins, 262
Sindbis virusdefective-interfering RNAs, 678persistent infection, 678virus RNAs, 678
Bluetongue virusneutralization
molecular basis, 627Bovine cells
bovine viral diarrhea virusvirus-specific RNA, 320
Bovine parvovirusproteins, 10
Bovine viral diarrhea virusbovine cells
virus-specific RNA, 320
Campoletis sonorensis virusparasitized host Heliothis virescens, 74
Carcinomanasopharyngeal
Epstein-Barr virus transcription, 580Cellular transcription
inhibitionvesicular stomatitis virus, 88
ChickensFujinami sarcoma virus
tumors, 744Rous sarcoma virus
tumors, 744tumors
Fujinami sarcoma virus, 744Rous sarcoma virus, 744
Chromatinadeno-associated virus DNA structure, 79
Chromosomehuman 5
assignment of c-fms locus, 770molecular cloning of c-fms locus, 770
Chromosomesreplicating simian virus 40
a-like DNA polymerase, 304in vitro DNA synthesis, 304
simian virus 40 T-antigen complexes, 281Coxsackievirusgroup B
inhibition of attachment, 561monoclonal antibodies, 561
Cytosinebacteriophage T4
in vivo cleavage, 18
Duck hepatitis B virussurface antigenmajor polypeptide, 534
Electron microscopymicroinjected simian virus 40
spliced cRNA, 296Epidermodysplasia verruciformishuman papillomavirus 8, 340human papillomavirus 10, 340human papillomavirus 3a, 340human papillomavirus 12, 340
Epstein-Barr virusabortive cycle
transcription of two distant clusters of partiallyhomologous small repeats, 731
DNA molecule organizationmRNA transcript, 135Notl repeat units, 135P3HR-I deletion junction, 135template, 13512-O-tetradecanoylphorbol-13-acetate, 135
lytic cycletranscription of two distant clusters of partially
homologous small repeats, 731nasopharyngeal carcinoma
transcription, 580transcription
nasopharyngeal carcinoma, 580Escherichia coli
bacteriophage P2-A interference, 616K-12
bacteriophage Mu growth, 149DNA polymerase I, 149
Eucaryotic cellsherpes simplex virus
class I defective DNA, 384European Elk papillomavirus
characterization of genome, 370induction of tumors in animals, 370transformation in vitro, 370
Exonucleasealkaline
herpes simplex virus type 1, 591
Feline sarcoma virusSnyder-Theilen
epidermal growth factor receptor metabolism, 752human A431 cells, 752protein kinase activity, 752
Foot-and-mouth disease virusserotypesmajor antigenic determinants, 451
Friend mink cell focus-inducing virusmolecular cloningnormal cells, 542transformed cells, 542
normal cellsmolecular cloning, 542
transformed cellsmolecular cloning, 542
Fujinami sarcoma virusfps gene
free of gag gene sequences, 744
J. VIROL.
SUBJECT INDEX v
induction of tumors in chickens, 744transformation of cells in culture, 744
Glycosylationsimian rotavirus SA 1I gene segment 10noncleaved signal peptide, 335
Ground squirrel hepatitis viruslivers
asymmetrical heterogeneous forms, Iclosed circular viral DNA, I
Hamster tumor cell lineintegrated polyomavirus DNA
structural analysis, 40Heliothis virescens
parasitized hostC. sonorensis virus, 74
Hemagglutinininfluenza virus A/PR/834
acid activation of hemolysis, 239mediation of hemolysis, 239monoclonal antibodies, 239
influenza virus H3antigenic drift, 52multiple evolutionary pathways, 52sequential amino acid changes, 52
monoclonal antibodiesinfluenza virus A/PR/834, 239irreversible antigenic alterations, 239
Hemolysisinfluenza virus A/PR/834
acid activation, 239mediation, 239
Hepatitis B virussurface antigen
expression of coding region, 271expression of entire gene, 271synthesis in mammalian cells, 271
Herpes simplex virusclass I defective DNA
eucaryotic cells, 384molecular cloning vehicle, 384
eucaryotic cellsclass I defective DNA, 384
insertion mutantsduplication of glycoprotein D gene, 396two forms of glycoprotein D, 396
type Ialkaline exonuclease, 591capsid protein, 591glycoprotein D synthesis and processing in vitro,
521glycoproteins, 325high-resolution characterization of transcripts,
591N-acetylgalactosaminyltransferase activity, 3250-glycosylation, 325short unique region, 460SmaI fragment, 460transcribed RNAs, 460
type 2glycoprotein D synthesis and processing in vitro,
521
Herpesvirus saimiritransformed lymphoid tumor cell line
virus-specific transcription, 377Human A431 cellsHarvey murine sarcoma virus
epidermal growth factor receptor metabolism, 752protein kinase activity, 752
Kirsten murine sarcoma virusepidermal growth factor receptor metabolism, 752protein kinase activity, 752
Snyder-Theilen feline sarcoma virusepidermal growth factor receptor metabolism, 752protein kinase activity, 752
Human adenovirus2
antipeptide antibodies, 604COOH terminus, 604EIB-19K tumor antigen, 604EIB-53K tumor antigen, 604NH2 terminus, 604
Human papillomavirus8
biochemical characterization, 340epidermodysplasia verruciformis, 340molecular cloning, 340
10biochemical characterization, 340epidermodysplasia verruciformis, 340molecular cloning, 340
3abiochemical characterization, 340epidermodysplasia verruciformis, 340molecular cloning, 340
12biochemical characterization, 340epidermodysplasia verruciformis, 340molecular cloning, 340
Human rhinovirushost range mutants
altered nonstructural proteins, 410
Influenza virusA/PR/834
acid activation of hemolysis, 239irreversible antigenic alterations, 239mediation of hemolysis, 239monoclonal anti-hemagglutinin antibodies, 239
H3 hemagglutininantigenic drift, 52multiple evolutionary pathways, 52sequential amino acid changes, 52
Interferonretrovirus
inhibition of DNA supercoiling, 120
Leupeptinmouse fibroblasts
inhibition of retrovirus infection, 765retrovirus
inhibition of infection in mouse fibroblasts, 765Lymphocytic choriomeningitis virusBHK cells
persistent infection, 262RNAs, 262viral proteins, 262
VOL. 48, 1983
vi SUBJECT INDEX
persistent infectionBHK cells, 262intracellular agent, 249standard cell lines, 249
standard cell linespersistent infection, 249
Lymphoid tumor cell lineH. saimiri-transformed
virus-specific transcription, 377
Mammalian cellshepatitis B surface antigen
synthesis, 271Mink cell focus-forming virusmouse chromosomal locus
genetic mapping, 300replicationmouse chromosomal locus, 300
Monkey cellsadenovirus type 2-simian virus 40 hybrid
adenovirus type 2 DNA-binding protein gene, 31independent, spontaneous mutants, 31
Mouse fibroblastsleupeptin
inhibition of retrovirus infection, 765retrovirus
inhibition of infection by leupeptin, 765Mouse hepatitis virus
replicative-intermediate RNAleader RNA sequences, 633nascent chains, 633
Mouse lymphoid cellsleukemic
retrovirus env transcript, 102normal
retrovirus env transcript, 102Mouse mammary tumor virusenv gene products
proteolytic cleavage sites, 314terminal amino acid sequences, 314
Murine leukemia virusBALB/c
physical mapping of Fv-1 tropism host rangedeterminant, 685
BALB/c B-tropicFv-1 host range property, 779nucleotide sequences of gag-pol regions, 779
BALB/c N-tropicFv-1 host range property, 779nucleotide sequences of gag-pol regions, 779
B-tropicgenome, 110in vitro restriction endonuclease fragment ex-
change, 110molecular clone, 110reversal of Fv-1 host range, 110
N-tropicgenome, 110in vitro restriction endonuclease fragment ex-
change, 110molecular clone, 110reversal of Fv-1 host range, 110
Murine sarcoma virusHarveyepidermal growth factor receptor metabolism, 752human A431 cells, 752
protein kinase activity, 752Kirsten
epidermal growth factor receptor metabolism, 752human A431 cells, 752protein kinase activity, 752
N-Acetylgalactosaminyltransferaseherpes simplex virus type I glycoproteins, 325
Newcastle disease virusepitopes
monoclonal antibodies, 440HN glycoproteinmonoclonal antibodies, 440
monoclonal antibodiesfour epitopes, 440HN glycoprotein, 440
Nuclear polyhedrosis virusA. californica
novel RNA polymerase, 641S. frugiperda cells, 641viral transcription, 641
0-glycosylationherpes simplex virus type I glycoproteins, 325
Phosphatidylethanolamineaccessibility in bacteriophage PM2 and gram-nega-
tive host, 774Phosphorylationpolyomavirus major capsid protein VPI, 206
Plasmidrecombinant
Aleutian disease virus antigens, 573Poliovirus
antibodybivalent attachment, 547conformational alteration and neutralization, 547genome-linked protein VPg, 429
genome-linked protein VPgantibody, 429NH2 terminus, 429synthetic nonapeptide, 429
in vitro RNA replicationinhibition, 429
native VPg, 429NH2 terminusgenome-linked protein VPg, 429
specific proteinssynthesis and cleavage, 309
synthetic nonapeptidegenome-linked protein VPg, 429
Polyadenylic acidadenovirus type 2 major late transcription unit
addition sites, 127PolyomavirusA2comparison with polyomavirus Crawford small-
plaque variant, 472antibodies
cross-reaction with cellular protein(s), 709middle T antigen, 709nonapeptide, 709
cellular protein(s)
J. VIROL.
SUBJECT INDEX vii
antibodies, 709middle T antigen, 709
Crawford small-plaque variantcomparison with polyomavirus A2, 472comparison with polyomavirus strain 3, 472DNA sequence, 472
integrated DNAhamster tumor cell line, 40structural analysis, 40
major structural protein VPIcarboxy-terminal region, 197chemical cleavage, 197cleavage products, 197major phosphorylation region, 206nonphosphorylated species, 206phosphorylated species, 206receptor moiety, 197
middle T antigenantibodies, 709cross-reaction with cellular protein(s), 709nonapeptide, 709
nonapeptideantibodies, 709middle T antigen, 709
strain 3comparison with polyomavirus Crawford small-
plaque variant, 472Protease
bacteriophage Cp-l DNAtransfection of S. pneumoniae, 721
S. pneumoniaetransfection by bacteriophage Cp-l DNA, 721
Protein kinaseHarvey murine sarcoma virushuman A431 cells, 752
human A431 cellsHarvey murine sarcoma virus, 752Kirsten murine sarcoma virus, 752Snyder-Theilen feline sarcoma virus, 752
Kirsten murine sarcoma virushuman A431 cells, 752
Snyder-Theilen feline sarcoma virushuman A431 cells, 752
Rabies virusanti-idiotypic antibodies
glycoprotein, 660glycoprotein
anti-idiotypic antibodies, 660neutralizing antibodies, 660
neutralizing antibodiesglycoprotein, 660
Restriction endonucleasefragment exchange in vitro
murine leukemia virus genomes, 110reversal of Fv-l host range, 110
RetrovirusDNA supercoiling
inhibition in interferon-treated cells, 120env transcriptleukemic mouse lymphoid cells, 102normal mouse lymphoid cells, 102
interferon-treated cellsinhibition of DNA supercoiling, 120
leupeptininhibition of infection in mouse fibroblasts, 765
mouse fibroblastsinhibition of infection by leupeptin, 765
RotavirusSAIIgene coding assignments, 330gene products, 330segments 7, 8, and 9, 330
Rous sarcoma virus115-nucleotide direct repeat
cis-acting RNA packaging locus, 667Schmidt-Ruppin-A
induction of tumors in chickens, 744src gene, 744transformation of cells in culture, 744
Serinesimian virus 40 VPI mutantcodons, 405
Simian rotavirusSAIIcoding assignment, 335gene segment 10, 335glycosylation sites, 335noncleaved signal peptide, 335nucleotide sequence, 335
Simian virus 40adenovirus type 2 hybridDNA-binding protein gene, 31independent, spontaneous mutants, 31monkey cells, 31
bacteriophage OX174 recombinant genomessingle cells, 229structure, 229
chromosome-T-antigen complexesearly replicating DNA intermediates, 281
functional origin of replicationsuper T antigen generation, 492transformed mouse cells, 492
in vitro DNA replicationinitiation, 481
late mRNA forms5' end sequences, 503
microinjectedelectron microscopy, 296spliced cRNA, 2%
nonhomologous recombination pathwayquantitation, 218
replicating chromosomesa-like DNA polymerase, 304in vitro DNA synthesis, 304
super T antigen generationfunctional origin of replication, 492transformed mouse cells, 492
transformed mouse cellsfunctional origin of replication, 492super T antigen generation, 492
VPI mutantmissense mutations, 405serine codons, 405suppression, 405viral agnogene, 405
Sindbis virusBHK cells
defective-interfering RNAs, 678persistent infection, 678
VOL. 48, 1983
viii SUBJECT INDEX
virus RNAs, 678persistent infectionBHK cells, 678defective-interfering RNAs, 678virus RNAs, 678
Spodoptera frugiperda cellsA. californica nuclear polyhedrosis virus
novel RNA polymerase, 641viral transcription, 641
Streptococcus pneumoniaebacteriophage Cp-l DNA
protease-sensitive transfection, 721protease-sensitive transfection
bacteriophage Cp-l DNA, 721Supercoiling
interferon-treated cellsinhibition, 120
retrovirus DNAinhibition, 120
12-O-Tetradecanoylphorbol- 13-acetateEpstein-Barr virusmRNA transcript, 135
Transformed mouse cellssimian virus 40
functional origin of replication, 492super T antigen generation, 492
Tumorschickens
Fujinami sarcoma virus, 744Rous sarcoma virus, 744
European Elk papillomavirus, 370Fujinami sarcoma virus
chickens, 744Rous sarcoma virus
chickens, 744
Vaccinia virusWR
correlation of genetic and physical maps, 419marker rescue, 419temperature-sensitive mutations, 419
Vesicular stomatitis virusserotype Indiana
inhibition of cellular transcription, 88viral leader RNA, 88
serotype New Jerseyinhibition of cellular transcription, 88viral leader RNA, 88
Viral leader RNAvesicular stomatitis virus
inhibition of cellular transcription, 88serotype Indiana, 88serotype New Jersey, 88
J. VIROL..