FIFTH INTERNATIONAL CNS GERM CELL TUMOR SYMPOSIUM

RENAISSANCE COLUMBUS DOWNTOWN HOTEL JUNE 7 - JUNE 10, 2017

Randall Lee Schieber

On behalf of the 2017 local organizing committee, we want to welcome you to downtown Columbus, Ohio, for the Fifth International Central Nervous System (CNS) Germ Cell Tumor Symposium. We do hope that you will enjoy your stay in our vibrant, welcoming cosmopolitan city. In addition to being the fifteenth largest city in the United States (US), the political capital city of the state of Ohio and a major commercial crossroad for half of the US population, Columbus is home to The Ohio State University, one of the largest public colleges in the US and to Nationwide Children’s Hospital, which is now the largest children’s hospital in the US. Furthermore, Columbus hosts a dynamic visual and performing arts scene (The Columbus Arts Festival, rated one of the top festivals in the nation, celebrates its 56th year of bringing the best in fine art and fine craft to downtown Columbus, June 9, 10 and 11.), many downtown restaurants in an environmentally conscious local-sourced culinary movement and, finally, professional sports (Columbus Blue Jackets hockey, Columbus Crew soccer and Columbus Clippers baseball).

We are especially honored to welcome both Dr. Masao Matsutano of Saitama, Japan and Dr. Jeffrey Allen of New York City, USA, as the first-ever recipients of the symposium’s Life Time Achievement Awards.

We are very pleased to welcome our internationally-renowned 20 Keynote speakers and 33 platform and poster session co-chairs from China, Japan, Taiwan, India, the United Kingdom, Italy, Australia, Germany, France, Argentina, Brazil, Canada and the United States.

Our overriding goal for this conference is to facilitate academic discussion on basic, translational and clinical aspects of CNS germ cell tumors stimulated by both platform and poster sessions and through networking. Speakers for the platform sessions were selected from among submitted abstracts with the assistance of our International Scientific Committee.

We are thrilled to be hosting, on the Saturday morning, a half-day satellite symposium particularly for CNS germ cell tumor patients and their families, with presentations by 13 clinicians and pertinent allied health care specialists in the field.

The conference schedule included in the Program book details the platform and poster sessions, meals, coffee/tea breaks and other social activities planned to aid you in networking, career development and collaboration.

We thank you for attending and hope you have an enjoyable and productive experience at the Fifth international CNS Germ Cell Tumor Symposium!

Sincerely,

WELCOME! SYMPOSIUM SPONSORS

Marvin D. Nelson, Jr, MD

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Jonathan L. Finlay, MB, ChB, FRCPConference Chair

Arnab Chakravarti, MDConference Co-Chair

Jeffrey R. Leonard, MDConference Co-Chair

TABLE OF CONTENTS

WELCOME LETTER .............................................................................................................................. 2

CONFERENCE SPONSORS ................................................................................................................... 3

GENERAL ANNOUNCEMENTS ............................................................................................................. 7

SYMPOSIUM PROGRAM AGENDA ....................................................................................................... 8

FAMILY MINI SYMPOSIUM PROGRAM AGENDA ................................................................................. 15

SYMPOSIUM FACULTY LISTING .......................................................................................................... 16

NOTES PAGE ....................................................................................................................................... 20

ABSTRACT INTRODUCTION – INCLUDES TITLE KEY .......................................................................... 22

ABSTRACT LISTING BY TITLE ............................................................................................................ 23

ABSTRACT LISTING BY AUTHOR ........................................................................................................ 31

COMMITTEES ...................................................................................................................................... 35

EXPERIENCE COLUMBUS, OHIO INFORMATION .................................................................................. 36

RESTAURANTS IN DOWNTOWN COLUMBUS ...................................................................................... 38

NOTES PAGES ..................................................................................................................................... 40

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ORAL PRESENTATIONSAll main symposium sessions will be held in the Hayes CDE Grand Ballroom. In addition to keynote addresses from leading authorities in aspects of basic, translational and innovative clinical research and management, there will be oral presentations from submitted abstracts. Time will be given for Q&A after each presentation.

POSTER SESSIONThe poster session will be held in the pre-function space outside of the Hayes Grand Ballroom on Thursday afternoon, June 8, 3:20 p.m.-4:20 p.m. All posters will be displayed during the entire symposium, beginning on Thursday morning, June 8.

Posters are numbered according to the Abstracts by Title section of this book and should be hung in the pre-function area on the poster board assigned to this number. Presenters should stand by their posters during the time of the poster session.

PATIENT/FAMILY MINI-SYMPOSIUMFor patients affected by CNS germ cell tumors, and for their immediate family members, we are hosting a special mini-conference on Saturday morning, June 10, with presentations by leading experts in the field on all aspects of survivorship. All presentations will be held in the Hayes A meeting room off the Grand Ballroom. The mini-symposium will conclude with lunch with physicians, scientists, psychologists, genetic counselors and social workers in the Hayes B meeting room.

CATERINGBreakfast, lunch and snacks will be offered throughout the symposium. Breakfast and snacks will be served outside the Hayes CDE meeting rooms in the pre-function area. Lunch will be served in the Hayes A and B meeting rooms.

EVENING EVENTSWelcome ReceptionWednesday, June 7, 2017 | 7:00 p.m. – 9:00 p.m.Renaissance Columbus Downtown Hotel | Cityview Terrace

All symposium attendees are invited to join us for cocktails and hors d’oeuvres at a special welcome reception on Wednesday evening.

Gala DinnerThursday, June 8, 2017 | 6:30 p.m. – 9:00 p.m.Columbus Museum of Art | 480 East Broad StreetDerby Court & The McCoy Family Broad Street Lobby$100 USD per person

Experience the glass sculpture of Dale Chihuly and a skylight ceiling filled with sun or stars in this grand and unique traditional space, the setting for the gala dinner. Guests will have access to galleries on the 1st and 2nd floors of the museum during the evening.

All symposium attendees are invited to the Gala Dinner. Shuttle service will be provided to and from the dinner. You must register in advance for the dinner. If you have not yet registered, please stop by the symposium registration desk.

LOCAL RESTAURANTS – GAY STREET DISTRICTSymposium attendees are free to have dinner on their own on Friday night. The following restaurants are within walking distance of the Columbus Renaissance Hotel:

Due Amici, $$Latitude 41 (inside the Columbus Renaissance), $$$Mitchell’s Steakhouse, $$$$ Tip Top Kitchen and Cocktails, $Elevator Brewery & Draught Haus, $$$

Average dinner entrée price:$ = under $10, $$ = $10-$15$$$ = $15-$20, $$$$ = $20+

See restaurant section on page 37 for other local establishments in the downtown area.

GENERAL ANNOUNCEMENTS

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FIFTH INTERNATIONAL CNS GERM CELL TUMOR CONFERENCEPROGRAM AGENDA

11:00 a.m. DIAGNOSTIC IMAGING | Hayes CDE Chairs: Professor Marvin Nelson, Los Angeles, CA; Professor Jerome Rusin, Columbus, OH

K5. Keynote Address: Professor Andrew Peet, Birmingham, UK

Oral Presentations

O5. Magnetic Resonance Spectroscopy in the Diagnosis of Primary CNS Germ Cell Tumors Professor Marvin Nelson, Los Angeles, CA

O6. Heme-sequences (Susceptibility Weighted Imaging and T2* Gradient Echo Sequences) in Midline and Off-midline Intra-cranial Germ Cell Tumors (GCT) Maria Luisa Garrè, Genoa, Italy

O7. Incidence of Optic Nerve Involvement in Pediatric Intracrancial Germ Cell Tumors Shannon M. MacDonald, Boston, MA

12:00 p.m. NEUROSURGICAL PRACTICE | Hayes CDE Sponsored by The Ohio State University Wexner Medical Center Department of Neurosurgery Chairs: Professor Jeffrey Leonard, Columbus, OH; Professor Mark Souweidane, New York, NY

K6. Lifetime Achievement Award: Professor Maseo Matsutani, Saitama, Japan Presented by Professor Ryo Nishikawa, Saitama, Japan Sponsored by Saitama Medical University International Medical Center

K7. Keynote Address: Professor Ryo Nishikawa, Saitama, Japan

Oral Presentations

O8. Time for a Change in Strategy: Radical Surgical Resection of Newly Diagnosed Primary Central Nervous System Mixed Malignant Germ Cell Tumors Professor Jeffrey R. Leonard, Columbus, OH

O9. Strategy for Central Nervous System Germ Cell Tumors with Residual Disease Following Chemotherapy and Radiotherapy Tomonari Suzuki, Saitama, Japan 1:10 p.m. LUNCH | Hayes AB

7:00-9:00 p.m. WELCOME RECEPTION | Cityview Terrace

7:00 a.m. REGISTRATION & BREAKFAST | Pre-Function 2nd Fl All 8:00 a.m. WELCOME | Professor Jonathan Finlay, Columbus, OH | Hayes CDE

8:10 a.m. THE WYSS FAMILY POPULATION AND MOLECULAR EPIDEMIOLOGY SESSION | Hayes CDE Chairs: Professor Eric Bouffet, Toronto, Canada; Dr. Jill Barnholtz-Sloan, Cleveland, OH

Population Epidemiology

K1. Keynote Address: Dr. Jill Barnholtz-Sloan, Cleveland, OH

K2. Wyss Family Distinguished Lecture Genetic Predisposition to Germ Cell Cancer Keynote Professor Ching Lau, Farmington, CT

Oral Presentations

O1. Canadian Patterns of Practice for Intracranial Germ Cell Tumors in Adolescents and Young Adults Andrea Lo, Toronto, Canada

O2. Primary Central Nervous System (CNS) Germ Cell Tumors in Down Syndrome Mohamed S. AbdelBaki, Columbus, OH

9:25 a.m. NEUROLOGICAL CONSIDERATIONS | Hayes CDE Sponsored by New York University School of Medicine in honor of Professor Jeffrey Allen Chairs: Professor Steve Roach, Columbus, OH; Professor Roger Packer, Washington, DC

K3. Keynote Address: Professor David Walker, Nottingham, UK

K4. Lifetime Achievement Award: Professor Jeffrey Allen, New York, NY Presented by Professor Roger Packer, Washington, DC

Oral Presentations

O3. Visual Complaints in Intracranial Germinomas Professor Didier Frappaz, Lyon, France

O4. Necessity for Histological Verification of Germinoma with Bifocal Lesion, Diabetes Insipidus and Normal Levels of Tumor Markers Masayuki Kanamori, Sendai, Japan 10:37 a.m. MORNING COFFEE BREAK | Pre-Function 2nd Fl All

WEDNESDAY JUNE 7

THURSDAY JUNE 8

THURSDAY JUNE 8 CONTINUED

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2:00 p.m. RADIATION ONCOLOGY PRACTICE | Hayes CDE Sponsored by The Ohio State University Wexner Medical Center Department of Radiation Oncology Chairs: Dr. Shannon MacDonald, Boston, MA; Professor Thomas Merchant, Memphis, TN; Dr. Erin Murphy, Cleveland, OH

K8. Keynote Address: Professor Thomas Merchant, Memphis, TN

Oral Presentations

O10. Dose-Reduced Radiotherapy with Platinum-Based Chemotherapy has Improved Quality of Life in the Long-Term Survivors with Central Nervous System Germinoma Kazuhiko Sugiyama, Hiroshima, Japan

O11. The Relationship Between Ventricular Size and Whole Brain Irradiation Dose in Central Nervous System Germ Cell Tumors Stephanie Toll, Los Angeles, CA

O12. Emergency Radiotherapy for Rapid Deterioration of Patients with Critical Intracranial Germ Cell Tumors – Twenty Case Reports Linbo Cai, Guangzhou, China

O13. Long-term Experience with Whole Ventricle Irradiation (WVI) for Central Nervous System (CNS) Germinoma Alice Indini, Milano, Italy

O14. A 40-Year Multi-Institutional Review of Intracranial Germ Cell Tumors in Adolescents and Young AdultsAndrea Lo, Toronto Canada

3:20 p.m. AFTERNOON TEA BREAK WITH POSTER PRESENTATIONS | Pre-Function 2nd Fl All Poster Moderators: Blanca Diez, Buenos Aires, Argentina; Takamitsu Fujimaki, Saitama, Japan

4:20 p.m. LATE EFFECTS/QUALITY OF SURVIVAL | Hayes CDE Chairs: Professor Charles Sklar, New York, NY; Professor Steven Sands, New York, NY

K9. Keynote Address: Professor Steven Sands, New York, NY

K10. Keynote Address: Professor Charles Sklar, New York, NY

Oral Presentations

O15. Neurocognitive Outcomes and Dosimetric Correlates in Central Nervous System Germ Cell Tumors: The St. Jude Experience Christopher L. Tinkle, Memphis, TN

O16. Neurocognitive and Psychological Functioning in Pediatric Patients with Intracranial Germ Cell Tumors (GCT) After Treatment Sonia Di Profio, Genoa, Italy

5:40 p.m. ADJOURN

6:30 p.m. GALA DINNER | Columbus Museum of Art | 480 E. Broad Street, Columbus, OH

7:00 a.m. BREAKFAST | Pre-Function 2nd Fl All

8:00 a.m. THERAPEUTICS OVERVIEW | Hayes CDE Professor Jonathan Finlay, Conference Chair, Columbus, OH

K11. Keynote Address: Dr. Lindsay Frazier, Boston, MA 8:30 a.m. PURE CNS GERMINOMAS | Hayes CDE Chairs: Professor James Nicholson, Cambridge, UK; Dr. Ute Bartels, Toronto, Canada; Dr. Soumen Khatua, Houston, TX

Oral Presentations

O17. The Second Interim Report of the Multi-institutional, Prospective Phase II Study of Radio-chemotherapy for Primary Intracranial Germinomas in Japan Professor Masao Matsutani, Saitama, Japan

O18. Value of Positive Cerebrospinal Fluid Cytology Without Further Macroscopic Dissemination in Patients with Intracranial Germinoma. Is There Room for Reduction of Treatment? Professor Gabriele Calaminus, Bonn, Germany

O19. Preliminary Results of a Brazilian Central Nervous System Germ Cell Tumor Consortium Protocol Andrea Cappellano, Sao Paulo, Brazil

O20. Clinical and Neuropsychological Outcome of Pediatric Non-Midline Central Nervous System Germinoma Treated with Chemotherapy and Reduced Dose/Volume Irradiation: Children’s Hospital Los Angeles Experience Kee Kiat Yeo, Los Angeles, CA

9:30 a.m. MORNING COFFEE BREAK | Pre-Function 2nd Fl All 10:00 a.m. MIXED MALIGNANT GERM CELL TUMORS | Hayes CDE

Chairs: Professor Gabriele Calaminus, Bonn, Germany; Dr. Girish Dhall, Los Angeles, CA

K12. Keynote: Professor Eric Bouffet, Toronto, Canada

Oral Presentations

O21. Impact on Outcome of Human Chorionic Gonadotropin-Beta (HCGβ) Elevations Alone in SIOP CNS GCT 96 Patients Treated as Non-geminomatous/Secreting Germ Cell Tumors (NGGCT) – Are we Over-Treating Germinoma? Dr. James C. Nicholson, Cambridge, UK

O22. Single Institution Experience with Intracranial Germ Cell Tumors Treated According to the SIOP CNS GCT Protocols Irene Slavc, Vienna, Austria

11:00 a.m. TERATOMA, MATURE AND IMMATURE | Hayes CDE

Chairs: Professor Tai-Tong Wong, Taipei, Taiwan; Dr. Andrea Cappellano, Sao Paolo, Brazil

K13. Keynote Address: Dr. Maria Luisa Garrè, Genova, Italy

FRIDAY JUNE 9

FIFTH INTERNATIONAL CNS GERM CELL TUMOR CONFERENCEPROGRAM AGENDA

THURSDAY JUNE 8 CONTINUED

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11:30 a.m. LUNCH | Hayes AB

1:00 p.m. RECURRENT CNS GERM CELL TUMORS | Hayes CDE Chairs: Professor Stewart Kellie, Sidney, Australia; Dr. Sharon Gardner, New York, NY; Dr. Jason Fangusaro, Chicago, IL

K14. Keynote Address: Dr. Darren Feldman, New York, NY

Oral Presentations

O23. National Survey for Relapsed Central Nervous System (CNS) Germ Cell Tumors (GCT) by the Japan Children’s Cancer Group Keita Terashima, Tokyo, Japan

O24. Relapse Pattern and Treatment Outcome of Recurrent Central Nervous System Germ Cell Tumors Takaaki Yanagisawa, Tokyo, Japan

O25. New Approaches to the Management of Recurrent Central Nervous System (CNS) Germinoma in the Current Molecular Era Diana S. Osorio, Columbus, OH

O26. Treatment and Outcomes of Central Nervous System Non-germinomatous Germ Cell Tumors with Early Relapse during Induction Chemotherapy Dr. Hung Tran, Los Angeles, CA

O27. New Approaches to the Management of Recurrent Central Nervous System (CNS) Mixed Malignant Germ Cell Tumors (MMGCT) in the Current Molecular Era Mohamed S. AbdelBaki, Columbus, OH

O28. Severe Central Nervous System (CNS) Damage Following High Dose Irradiation and Subsequent Multiple Cycle Marrow-Ablative Chemotherapy for Pediatric/Adolescent Recurrent CNS Malignant Germ Cell Tumors Rolla Abu-Arja, Columbus, OH

2:50 p.m. GERM CELL CANCER METASTATIC TO THE CNS | Hayes CDE Chairs: Dr. Mark Ranalli, Columbus, OH; Professor Vinay Pudovalli, Columbus, OH

K15. Keynote Address: Dr. Mark Ranalli, Columbus, OH

3:20 p.m. AFTERNOON TEA BREAK | Pre-Function 2nd Fl All

4:00 p.m. MANAGEMENT OF CNS GERM CELL TUMORS IN DEVELOPING COUNTRIES | Hayes CDEChairs: Professor Rakesh Jalali, Mumbai, India; Professor Zhong-ping Chen, Guangzhou, China; Dr. Ibrahim Qaddoumi, Memphis, TN

K16. Keynote Address: Professor Rakesh Jalali, Mumbai, India

K17. Keynote Address: Professor Zhong-ping Chen, Guangzhou, China

Oral Presentations

O29. Central Nervous System Germ Cell Tumors: Experience of a Referral Center in Guatemala Ana Verónica Girón, Guatemala City, Guatemala

O30. New Approaches to the Irradiation-Free Management of Central Nervous System (CNS) Germ Cell Tumors (GCT) in the Developing World Professor Jonathan L. Finlay, Columbus, OH

5:25 p.m. ROUND TABLE DISCUSSION AND OPEN FORUM: THE FUTURE MANAGEMENT OF CNS GERM CELL TUMORS – IN WHICH DIRECTION? | Hayes CDE Chairs: Professor Jonathan Finlay, Columbus, OH; Professor Jeffrey Leonard, Columbus, OH

Participants: Professor Mark Souweidane, Professor Thomas Merchant, Professor Ryo Nishikawa, Professor Rakesh Jalali, Professor Tai-Tong Wong, Professor Eric Bouffet, Professor Gabriel Calaminus, Professor Jeffrey Allen, Professor Maseo Matsutani 6:15 p.m. FRIDAY EVENING FREE FOR REGISTRANTS

FIFTH INTERNATIONAL CNS GERM CELL TUMOR CONFERENCEPROGRAM AGENDA

FRIDAY JUNE 9 CONTINUED

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FIFTH INTERNATIONAL CNS GERM CELL TUMOR CONFERENCEPROGRAM AGENDA

SATURDAY, JUNE 10

7:00 a.m. BREAKFAST | Pre-Function 2nd Fl All

8:00 a.m. DEVELOPMENTAL BIOLOGY OF GERM CELL TUMORS | Hayes CDE Sponsored by Alex’s Lemonade Stand Foundation for Childhood Cancer

Chairs: Professor Koichi Ichimura, Tokyo, Japan; Professor Azim Surani, Cambridge, UK

K18. Keynote Address: Professor Koichi Ichimura, Tokyo, Japan

K19. Keynote Address: Professor Azim Surani, Cambridge, UK 9:00 a.m. PATHOLOGY AND MOLECULAR BIOLOGY OF CNS GERM CELL TUMORS | Hayes CDE Sponsored by The Matthew Larson Foundation for Pediatric Brain Tumors

Chairs: Dr. Matthew Murray, Cambridge, UK; Professor Ching Lau, Farmington, CT

K20. Keynote Address: Dr. James Amatruda, Dallas, TX

K21. Keynote Address: Professor Bette Kleinschmidt-DeMasters, Denver, CO 10:00 a.m. MORNING COFFEE BREAK | Pre-Function 2nd Fl All

10:45 a.m. PATHOLOGY AND MOLECULAR BIOLOGY OF CNS GERM CELL TUMORS (CONTINUED) |Hayes CDE

K22. Keynote Address: Professor Elaine Mardis, Columbus, OH

Oral Presentations

O31. Towards Non-invasive MicroRNA-based Diagnosis and Risk-Stratification of Central Nervous System (CNS) Malignant Germ Cell Tumors: A Proposed Pathway Dr. Matthew Murray, Cambridge, UK

O32. Correlation of Clinical and Molecular Aspects of Central Nervous System Germ Cell Tumors: A Clinical and Research Experience in a Cohort Series in Taiwan Professor Tai-Tong Wong, Taipei, Taiwan

O33. PD-L and PD-1 are Associated with Tumor-Infiltrating Lymphocytes in Intracranial Germinoma Yoshiki Arakawa, Kyoto, Japan

11:55 a.m. CLOSING REMARKS | Hayes CDE Professor Jonathan Finlay, Columbus, OH; Professor Gabriele Calaminus, Bonn, Germany 12:15 p.m. ADJOURN - LUNCH | Hayes B

7:00 a.m. REGISTRATION & BREAKFAST | Pre-Function 2nd Fl All 8:00 a.m. Introduction and Overview of Long-Term Survivoryship | Hayes A Dr. Saro Armenian, Los Angeles, CA

8:30 a.m. Genetic Counseling for Childhood CNS Germ Cell Tumors | Hayes A Ms. Kristin Zajo, Columbus, OH

8:50 a.m. Neurosurgical Issues: Life Long Shunt Management | Hayes A Professor Jeffrey Leonard, Columbus, OH

9:10 a.m. Growth and Physical Development Outcomes | Hayes A Professor Charles Sklar, New York, NY

9:30 a.m. Fertility and Reproductive Outcomes | Hayes A Dr. Leena Nahata, Columbus, OH

9:50 a.m. Cerebrovascular Outcomes | Hayes A Dr. Sabine Mueller, San Francisco, CA

10:10 a.m. MORNING COFFEE AND SNACK BREAK | Pre-Function 2nd Fl All

10:30 a.m. Cognitive/Intellectual Outcomes | Hayes A Professor Stephen Sands, New York, NY

10:50 a.m. Quality of Life Outcomes | Hayes A Dr. Tammi Young-Saleme, Columbus, OH

11:10 a.m. Rehab of Children with Brain Tumors over the Long Term | Hayes A Dr. Nathan Rosenberg, Columbus, OH

11:30 a.m. Hearing Outcomes | Hayes A Ms. Kristin Knight, Portland, OR

11:50 a.m. Second Cancers Following Treatment of CNS Germ Cell Tumors | Hayes A Dr. Randal Olshefski, Columbus, OH

12:10 p.m. Round Table Discussion | Hayes A Speakers + Ms. Jaime Banks, Bethesda, MD

1:00 p.m. LUNCH WITH PHYSICIANS, SCIENTISTS, PSYCHOLOGISTS, GENETICS COUNSELORS AND SOCIAL WORKERS | Hayes B Summation Professor Jonathan Finlay, Conference Chair, Columbus, OH

FIFTH INTERNATIONAL CNS GERM CELL TUMOR CONFERENCEPATIENT/FAMILY MINI-SYMPOSIUMRENAISSANCE COLUMBUS DOWNTOWN HOTEL

SATURDAY, JUNE 10TH

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KEYNOTE SPEAKERS – MAIN SYMPOSIUMJames F. Amatruda, MD, PhDUniversity of Texas Southwestern Medical Center, Dallas, Texas, United States

Jill S. Barnholtz-Sloan, PhDCase Western Reserve University School of Medicine, Cleveland, Ohio, United States

Eric Bouffet, MDThe Hospital for Sick Children, Toronto, Ontario, Canada

Zhong-ping Chen, MDSun Yat-sen University Cancer Center, Guangzhou, China

Bette Kleinschmidt DeMasters, MDUniversity of Colorado School of Medicine, Denver, Colorado, United States

Darren Feldman, MDMemorial Sloan-Kettering Cancer Center, New York City, New York, United States

A.Lindsay Frazier, MDDana-Farber Cancer Institute, Boston, Massachusetts, United States

Maria Luisa Garrè, MDGiannina Gaslini Children’s Hospital, Genoa, Italy

Koichi Ichimura, MDNational Cancer Center Research Institute, Tokyo, Japan

Rakesh Jalali, MBBS, MDTata Memorial Hospital, Mumbai, India

Ching Lau, MDConnecticut Children’s Medical Center, Hartford, Connecticut, United States

Elaine Mardis, MDNationwide Children’s Hospital, Columbus, Ohio, United States

Thomas Merchant, DO, PhDSt. Jude’s Children’s Research Center, Memphis, Tennessee, United States

Ryo Nishikawa, MD, PhDSaitama Medical University International Medical Center, Saitama, Japan

Andrew Peet, PhD, MBBSUniversity of Birmingham, Birmingham, United Kingdom

Mark Ranalli, MDNationwide Children’s Hospital, Columbus, Ohio, United States

Stephen Sands, DPsyMemorial Sloan-Kettering Cancer Center, New York City, New York, United States

Charles Sklar, MDMemorial Sloan-Kettering Cancer Center, New York City, New York, United States

Azim Surani, PhDWellcome Trust/CRUK Gurdon Institute, University of Cambridge, Cambridge, United Kingdom

David Walker, MDChildren’s Brain Tumor Research Centre, University of Nottingham, Nottingham, United Kingdom

SYMPOSIUM FACULTY LISTING

SESSION CO-CHAIRS – MAIN SYMPOSIUMJill S. Barnholtz-Sloan, PhDCase Western Reserve University School of Medicine, Cleveland, Ohio, United States

Ute Bartels, MDHospital for Sick Children; Toronto, Ontario, Canada

Eric Bouffet, MDThe Hospital for Sick Children, Toronto, Ontario, Canada

Gabriele Calaminus, MDMünster University Hospital, Münster, Germany

Andrea Cappellano, MDPediatric Oncology Institute, São Paulo, Brazil

Zhong-ping Chen, MDSun Yat-sen University Cancer Center, Guangzhou, China

Girish Dhall, MDChildren’s Hospital of Los Angeles, Los Angeles, California, United States

Jason Fangusaro, MDAnn and Robert H. Lurie Children’s Hospital, Chicago, Illinois, United States

Jonathan L. Finlay, MB ChB, FRCPNationwide Children’s Hospital, Columbus, Ohio, United States

Sharon Gardner, MDNew York University Langone Medical Center, New York, New York City, United States

Koichi Ichimura, MDNational Cancer Center Research Institute, Tokyo, Japan

Rakesh Jalali, MBBS, MDTata Memorial Hospital, Mumbai, Indi

Stewart Kellie, MDChildren’s Hospital at West Mead, Sydney, Australia

Soumen Khatua, MDMD Anderson Cancer Center, Houston, Texas, United States

Ching Lau, MDConnecticut Children’s Medical Center, Hartford, Connecticut, United States

Jeffrey R. Leonard, MDNationwide Children’s Hospital, Columbus, Ohio, United States

Shannon MacDonald, MDMassachusetts General Hospital, Boston, Massachusetts, United States

Thomas Merchant, DO, PhDSt. Jude’s Children’s Research Center, Memphis, Tennessee, United States

Erin Murphy, MDCleveland Clinic, Cleveland, Ohio, United States

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SESSION CO-CHAIRS – MAIN SYMPOSIUM CONTINUEDMatthew Murray, MDUniversity of Cambridge, Cambridge, United Kingdom

Marvin Nelson, MDChildren’s Hospital of Los Angeles, Los Angeles, California, United States

James C. Nicholson, MDCambridge University Hospitals NHS Trust, Cambridge, United Kingdom

Roger Packer, MDChildren’s National Medical Center, Washington, DC, United States

Vinay Puduvalli, MDThe Ohio State University Wexner Medical Center, Columbus, Ohio, United States

Ibrahim Qaddoumi, MDSt. Jude Children’s Research Hospital, Memphis, Tennessee, United States

Mark Ranalli, MDNationwide Children’s Hospital, Columbus, Ohio, United States

E. Steve Roach, MDNationwide Children’s Hospital, Columbus, Ohio, United States

Jerome Rusin, MDNationwide Children’s Hospital, Columbus, Ohio, United States

Stephen Sands, PsyDMemorial Sloan-Kettering Cancer Center, New York City, New York, United States

Charles Sklar, MDMemorial Sloan-Kettering Cancer Center, New York City, New York, United States

Mark Souweidane, MDWeill Cornell Medicine and New York-Presbyterian Hospital, New York, New York, United States

Azim Surani, PhDWellcome Trust/CRUK Gurdon Institute, University of Cambridge, Cambridge, United Kingdom

Tai-Tong Wong, MDTaipei Medical University Hospital, Taipei, Taiwan

INTERNATIONAL POSTER MODERATORSBlanca Diez, MDFoundation for the Fight against Neurological Diseases of Children, Buenos Aires, Argentina

Takamitsu Fujimaki, MD, PhDSaitama Medical University International Medical Center, Saitama, Japan

LIFETIME ACHIEVEMENT AWARD RECIPIENTSJeffrey C. Allen, MDNYU Langone Medical Center, New York, New York, United States

Masao Matsutani, MDSaitama Medical University, Saitama, Japan

SYMPOSIUM FACULTY LISTING

FAMILY/PATIENT MINI-SYMPOSIUM SPEAKERSSaro Armenian, DO, MPHCity of Hope, Los Angeles, California, United States

Jaime BanksBethesda, Maryland, United States

Jonathan Finlay, MB, ChB, FRCPNationwide Children’s Hospital, Columbus, Ohio, United States

Kristin Knight, MSOregon Health and Science University, Portland, Oregon, United States

Jeffrey Leonard, MDNationwide Children’s Hospital, Columbus, Ohio, United States

Sabine Mueller, MD, PhDUniversity of California San Francisco, San Francisco, California, United States

Leena Nahata, MDNationwide Children’s Hospital, Columbus, Ohio, United States

Randal Olshefki, MDNationwide Children’s Hospital, Columbus, Ohio, United States

Nathan Rosenberg, MDNationwide Children’s Hospital, Columbus, Ohio, United States

Stephen Sands, PsyDMemorial Sloan-Kettering Cancer Center, New York, New York, United States

Charles Sklar, MDMemorial Sloan-Kettering Cancer Center, New York, New York, United States

Tammi Young-Saleme, PhDNationwide Children’s Hospital, Columbus, Ohio, United States

Kristin Zajo, MA, MS, LGCNationwide Children’s Hospital, Columbus, Ohio, United States

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NOTES

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SYMPOSIUM ABSTRACTS

We are pleased to introduce the abstracts accepted for presentation at the Fifth International Central Nervous System Germ Cell Tumor Conference, being held June 7th through the 10th 2017 in Columbus, Ohio, USA.

The first of these conferences was held in 2003 in Tokyo, organized by Dr. Masao Matsutani; the second in Los Angeles in 2005 by Dr. Jonathan Finlay; the third in 2013 in Cambridge, England, organized by Dr. James Nicholson; and the fourth by Dr. Ryo Nishikawa in Tokyo in 2015. These conferences have brought together multi-disciplinary leaders from around the world to both update one another and attempt to resolve the many controversies that have persisted in the optimal diagnosis and management of these relatively rare tumors – which are nevertheless amongst the most common primary malignant brain tumors of childhood and adolescence in East Asia. Indeed, published consensus statements have emerged from the conferences and hopefully will continue to do so, in large measure predicated upon the information discussed and provided within many of these abstracts.

Jonathan L. Finlay, MB, ChB, FRCP, Conference Chair

Arnab Chakravarti, MD, Conference Co-Chair

Jeffrey R. Leonard, MD, Conference Co-Chair

Nationwide Children’s Hospital and The Ohio State University, Columbus, Ohio, USA

ABSTRACT TITLE KEY:K KEYNOTE INVITED PRESENTATIONS

O ORAL ABSTRACT PRESENTATIONS

P POSTER ABSTRACTS

SS SATURDAY SYMPOSIUM INVITED PRESENTATIONS

ABSTRACTS BY TITLE

K1. EPIDEMIOLOGY OF CENTRAL NERVOUS SYSTEM GERM CELL TUMORS.Jill Barnholtz-Sloan, Sally S. Morley Designated Professor in Brain Tumor Research, Professor and Associate Director for Bioinformatics/Translational Informatics, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

K2. GENETIC PREDISPOSITION TO INTRACRANIAL GERM CELL TUMORS. Ching C. Lau, Connecticut Children’s Medical Center, Jackson Laboratory for Genomic Medicine, University of Connecticut School of Medicine, Hartford/Farmington, Connecticut, USA.

K3. HEADSMART EARLY DIAGNOSIS OF BRAIN TUMORS: A NEW FOCUS FOR PRECISION MEDICINE (WWW.HEADSMART.ORG.UK).David Walker, Children’s Brain Tumour Research Centre (CBTRC), Division of Child Health and Obstetrics and Gynaecology School of Medicine, University of Nottingham, Nottingham, United Kingdom.

K4. LIFETIME ACHIEVEMENT AWARD PRESENTATION. Jeffrey C. Allen, Professor of Pediatrics and Neurology, New York Langone Medical Center, New York, USA.

K5. FUNCTIONAL IMAGING OF CENTRAL NERVOUS SYSTEM (CNS) GERM CELL TUMORS IN CHILDREN. Andrew C. Peet, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom.K6. Lifetime Achievement Award Presentation. Masao Matsutani, M.D., DMSci., Professor Emeritus, Department of Neuro-oncology and Neurosurgery, Saitama Medical University, Saitama, Japan.

K6. LIFE TIME ACHIEVEMENT AWARD PRESENTATION.Masao Matsutani, MD, DMSci, Professor Emeritus, Department of Neuro-Oncology/Neurosurgery, Saitama Medical University, Saitama, Japan.

K7. SURGICAL ASPECTS OF PRIMARY CENTRAL NERVOUS SYSTEM (CNS) GERM CELL TUMORS. Ryo Nishikawa. Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Saitama, Japan.

K8. RADIATION THERAPY MANAGEMENT OF CENTRAL NERVOUS SYSTEM GERM CELL TUMORS. Thomas E. Merchant. Chair, Radiation Oncology Department, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA.

K9. LATE MEDICAL COMPLICATIONS IN SURVIVORS OF CENTRAL NERVOUS SYSTEM (CNS) GERM CELL TUMORS. Charles A. Sklar, MD. Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, USA.

K10. LATE EFFECTS AND QUALITY OF SURVIVAL OF CHILDREN AND ADOLESCENTS WITH PRIMARY CENTRAL NERVOUS SYSTEM (CNS) GERM CELL TUMORS. Stephen A. Sands, Director of Pediatric Neuropsychology, Memorial Sloan Kettering Cancer Center, New York, USA.

K11. PEDIATRIC MALIGNANT GERM CELL TUMORS: A COMPARISON OF THE NEURO-ONCOLOGY AND SOLID TUMOR EXPERIENCE. A. Lindsay Frazier, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.

K12. NON-GERMINOMATOUS GERM CELL TUMORS OF THE CENTRAL NERVOUS SYSTEM: FROM CACOPHONY TO HARMONY? Eric Bouffet, the Hospital for Sick Children, Toronto, Canada.

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K13. CURRENT MANAGEMENT OF MATURE AND IMMATURE TERATOMAS OF THE CENTRAL NERVOUS SYSTEM (CNS). Maria Luisa Garrè, 1 Giovanni Morana, 2 Luca Ramenghi, 3 Claudia Milanaccio, 1 Armando Cama, 4 Luisella Bertoluzzo, 5 Andrea Rossi, 2 Riccardo Haupt. 5 Neuro-oncology Unit, 1 Neuroradiology, 2 Neonatology Unit, 3 Neurosurgery Unit, 4 Epidemiology Unity, 5 Istituto Giannina Gaslini, Italy.

K14. NOVEL TREATMENT APPROACHES TO RELAPSED/REFRACTORY GERM CELL TUMORS. Darren R. Feldman, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA.

K15. CENTRAL NERVOUS SYSTEM (CNS) METASTASES FROM PRIMARY SYSTEMIC GERM CELL TUMORS (GCT) OF CHILDREN, ADOLESCENTS AND YOUNG ADULTS. Mark A. Ranalli, MD, Associate Professor of Pediatrics, The Ohio State University College of Medicine. Director, Embryonal Tumor Program, Division of Hematology, Oncology and Bone Marrow Transplantation, Nationwide Children’s Hospital, Columbus, Ohio, USA.

K16. MANAGEMENT OF CNS GERM CELL TUMORS IN DEVELOPING COUNTRIES. Rakesh Jalali and Raees Tonse. Neuro Oncology Group, Tata Memorial Hospital, Mumbai, India.

K17. MANAGEMENT OF CENTRAL NERVOUS SYSTEM GERM CELL TUMORS IN CHINA. Zhong-ping Chen, Department of Neurosurgery/Neuro-oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.

K18. CELLULAR ORIGIN OF CENTRAL NERVOUS SYSTEM GERM CELL TUMORS. Koichi Ichimura,1,3 Shintaro Fukushima,1,3 Hirokazu Takami,1,3 Yoshiko Nakano,1 Sakura Kuzuoka, 1,3 Masao Matsutani, 2,3 Ryo Nishikawa, 2,3 on behalf of The Intracranial Germ Cell Tumor Genome Analysis Consortium.3 Division of Brain Tumor Translational Research, National Cancer Center, Tokyo, Japan,1 Department of Neuro-oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka, Japan,2 and The Intracranial Germ Cell Tumor Genome Analysis Consortium.3

K19. HUMAN GERMLINE: SPECIFICATION AND EPIGENETIC PROGRAMMING. Azim Surani, Wellcome Trust Cambridge Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, United Kingdom.

K20. EGF RECEPTOR AND MTORC1 ARE NOVEL THERAPEUTIC TARGETS IN NON-SEMINOMATOUS GERM CELL TUMORS. Kenneth S. Chen,1,6 Nicholas J. Fustin,o1,6 Christina Ateek,1 Abhay A. Shukla,1,2 Sarai Stuart,1,4 Kiyoshi Yamaguchi,3,7 Payal Kapur,4 A. Lindsay Frazier,8 Lawrence Lum,3 Leendert H.J. Looijenga,9 Theodore Laetsch,1,6 Dinesh Rakheja1,4 and James F. Amatruda.1,2,5,6 Departments of Pediatrics,1 Molecular Biology,2 Cell Biology,3 Pathology,4 and Internal Medicine,5 University of Texas Southwestern Medical Center; Margaret Gill Center for Cancer and Blood Disorders, Children’s Health, Dallas, TX 75390, USA;6 Division of Clinical Genome Research, Institute of Medical Science, University of Tokyo, Tokyo, Japan;7 Department of Pediatric Oncology, Children’s Hospital Dana-Farber Cancer Care, Boston MA 02115, USA;8 Department of Pathology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands.9

K21. CHALLENGES REMAIN IN CENTRAL NERVOUS SYSTEM (CNS) GERM CELL TUMOR DIAGNOSIS. Bettie Kleinschmidt-DeMasters, Department of Neuropathology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

K22. IMMUNOGENOMICS OF BRAIN CANCERS. Elaine R. Mardis, Institute for Genomic Medicine, Nationwide Children’s Hospital and The Ohio State University, Columbus, Ohio, USA.

O1. CANADIAN PATTERNS OF PRACTICE FOR INTRACRANIAL GERM CELL TUMORS IN ADOLESCENTS AND YOUNG ADULTS. Andrea Lo, 1,2 Normand Laperriere,1,3 David Hodgson,1,3 Eric Bouffet,3 James Nicholson,4 Michael McKenzie,2 Juliette Hukin,5 and Karen Goddard.2,5 Princess Margaret Cancer Centre, Toronto, Ontario, Canada,1 British Columbia Cancer Agency, Vancouver, British Columbia, Canada,2 The Hospital for Sick Children, Toronto, Ontario, Canada,3 Addenbrooke’s Hospital, Cambridge, United Kingdom,4 and The British Columbia Children’s Hospital, Vancouver, British Columbia, Canada.5

O2. PRIMARY CENTRAL NERVOUS SYSTEM (CNS) GERM CELL TUMORS IN DOWN SYNDROME. Mohamed S. AbdelBaki,1 Jeffrey Leonard,1,2 Joseph Torkildson,3 Jerry Cheng,4 Ricardo X. Wang,4 Kenneth E. Wong,5 Torunn Yock,6 Girish Dhall5 and Jonathan L Finlay.1 The Neuro-oncology Program, Divisions of Hematology, Oncology and BMT1 and Neurosurgery2, The Research Institute of Nationwide Children’s Hospital and The Ohio State University, Columbus, Ohio, the Children’s Hospital of Oakland, California, USA,3 Kaiser Permanente of Southern California, Los Angeles, California, USA,4 the Children’s Center for Cancer and Blood Diseases, Children’s Hospital Los Angeles, California, USA, 5 and the Radiation Oncology Program, Massachusetts General Hospital, Boston, Massachusetts, USA.6

O3. VISUAL COMPLAINTS IN INTRACRANIAL GERMINOMAS. Didier Frappaz,1 Claire Pedone,1 Philippe Thiesse,2 Alexandru Szathmari,4 Cécile Faure Conter,1 Carmine Mottolese,4 Christian Carrie2, Departments of Oncology,1 Radiology,2 and Radiotherapy,3 Institut d’Hématologie et d’Oncologie Pédiatrique, Lyon, France, and the Department of Neurosurgery, Hospital Wertheimer, Bron, France.3

O4. NECESSITY FOR HISTOLOGICAL VERIFICATION OF GERMINOMA WITH BIFOCAL LESION, DIABETES INSIPIDUS AND NORMAL LEVELS OF TUMOR MARKERS. Masayuki Kanamori, Hirokazu Takami, Ryuta Saito, Teiji Tominaga, Kochi Ichimura, Ryo Nishikawa. Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

O5. MAGNETIC RESONANCE SPECTROSCOPY IN THE DIAGNOSIS OF PRIMARY CNS GERM CELL TUMORS. Stefan Blüml, Benita Tamrazi, Marvin D. Nelson, Department of Radiology, Division of Neuroradiology, Children’s Hospital Los Angeles, Los Angeles, California, USA

O6. HEME-SEQUENCES (SUSCEPTIBILITY WEIGHTED IMAGING AND T2* GRADIENT ECHO SEQUENCES) IN MIDLINE AND OFF-MIDLINE INTRA-CRANIAL GERM CELL TUMORS (GCT). Giovanni Morana,1 Cesar Augusto Alves, 2 Domenico Tortora, 1 Maria Savina Severino, 1 Paolo Nozza, 3 Armando Cama, 4 Antonio Verrico, 5 Claudia Milanaccio, 5 Andrea Rossi, 1 Maria Luisa Garrè.5 The Neuroradiology Unit, Istituto Giannina Gaslini, Genova, Italy,1 The Radiology Institute, Hospital das Clinicas, Sao Paulo, Brasil,2 The Pathology Unit, Istituto Giannina Gaslini, Genova, Italy,3 The Neurosurgery Unit, Istituto Giannina Gaslini, Genova, Italy,4 and the Neuro-oncology Unit, Istituto Giannina Gaslini, Genova, Italy.5

O7. INCIDENCE OF OPTIC NERVE INVOLVEMENT IN PEDIATRIC INTRACRANIAL GERM CELL TUMORS. Shannon M. MacDonald,1 Guy Savir,1 Joanna Y. Chin,2 Roshan V. Sethi,2 Claire P. Goebel,1 Otto Rapalino,3 Torunn I. Yock, 1 Nancy J. Tarbell1 and Paul Caruso.3 Department of Radiation Oncology, Massachusetts General Hospital;1 Harvard Radiation Oncology Program;2 Department of Radiology, Massachusetts General Hospital,3 Boston, Massachusetts, USA.

O8. TIME FOR A CHANGE IN STRATEGY: RADICAL SURGICAL RESECTION OF NEWLY DIAGNOSED PRIMARY CENTRAL NERVOUS SYSTEM MIXED MALIGNANT GERM CELL TUMORS. Jeffrey R. Leonard and Jonathan L. Finlay, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio, USA.

ABSTRACTS BY TITLE

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O9. STRATEGY FOR CENTRAL NERVOUS SYSTEM GERM CELL TUMORS WITH RESIDUAL DISEASE FOLLOWING CHEMOTHERAPY AND RADIOTHERAPY. Tomonari Suzuki,1 Eita Uchida,1 Yohei Miyake,1 Yusuke Kobayashi,1 Jun-ichi Adachi,1 Takamitsu Fujimaki,2 Takaaki Yanagisawa,3 Kazuhiko Mishima1 and Ryo Nishikawa.1 Saitama Medical University International Medical Center, Hidaka, Japan,1 Saitama Medical University Hospital, Moroyama, Japan2 and Jikei University School of Medicine, Tokyo, Japan.3

O10. DOSE-REDUCED RADIOTHERAPY WITH PLATINUM-BASED CHEMOTHERAPY HAS IMPROVED QUALITY OF LIFE IN THE LONG-TERM SURVIVORS WITH CENTRAL NERVOUS SYSTEM GERMINOMA. Kazuhiko Sugiyama,1 Fumiyuki Yamasaki,2 Kaoru Kurisu,2 and Kazunori Arita.3 Department of Clinical Oncology, Hiroshima University Hospital,1 Department of Neurosurgery, Hiroshima University Hospital,2 and Department of Neurosurgery, Kagoshima University Hospital.3

O11. THE RELATIONSHIP BETWEEN VENTRICULAR SIZE AND WHOLE BRAIN IRRADIATION DOSE IN CENTRAL NERVOUS SYSTEM GERM CELL TUMORS. Stephanie Toll, Marjorie Jones, Emi J. Yoshida, Arthur Olch, Girish Dhall and Kenneth Wong. The Children’s Hospital of Los Angeles, Los Angeles, California, USA.

O12. EMERGENCY RADIOTHERAPY FOR RAPID DETERIORATION OF PATIENTS WITH CRITICAL INTRACRANIAL GERM CELL TUMORS - TWENTY CASE REPORTS. Linbo Cai, Xiaoguang Qiu, Mingyao Lai, Changguo Shan, Weiping Hong, Juan Li, Jiangfen Zhou, Ping Zhang, Lichao Wang, The Department of Oncology, Guangdong 999 Brain Hospital, Guangzhou, China.

O13. LONG-TERM EXPERIENCE WITH WHOLE VENTRICLE IRRADIATION (WVI) FOR CENTRAL NERVOUS SYSTEM (CNS) GERMINOMA. Alice Indini, Veronica Biassoni, Elisabetta Schiavello, Barbara Diletto, Emilia Pecori, Lorenza Gandola and Maura Massimino, Institute Besta, Milano, Italy.

O14. A 40-YEAR MULTI-INSTITUTIONAL REVIEW OF INTRACRANIAL GERM CELL TUMORS IN ADOLESCENTS AND YOUNG ADULTS. Andrea Lo, 1,2,6,7 Karen Goddard, 2,5,7 David Hodgson, 1,3,6 Jennifer Dang, 1 Scott Tyldesley, 2,7 Eric Bouffet, 3,6 Ute Bartels, 3,6 Sylvia Cheng, 5,7 Juliette Hukin, 5,7 Philippe Bedard, 1,6 Normand Laperriere. 1,3,6 Princess Margaret Cancer Centre, Toronto, Ontario, Canada;1 British Columbia Cancer Agency, Vancouver, British Columbia, Canada;2 The Hospital for Sick Children, Toronto, Ontario, Canada;3 British Columbia Children’s Hospital, Vancouver, British Columbia, Canada;5 University of Toronto, Toronto, Ontario, Canada;6 University of British Columbia, Vancouver, British Columbia, Canada.7

O15. NEUROCOGNITIVE OUTCOMES AND DOSIMETRIC CORRELATES IN CENTRAL NERVOUS SYSTEM GERM CELL TUMORS: THE ST. JUDE EXPERIENCE. Christopher L. Tinkle, Sudharsan Srinivasan, Sarah Scott, Yimei Li, Amar Gajjar, Heather Conklin, Thomas E. Merchant and Jonathan Farr, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

O16. NEUROCOGNITIVE AND PSYCHOLOGICAL FUNCTIONING IN PEDIATRIC PATIENTS WITH INTRACRANIAL GERM CELL TUMORS (GCT) AFTER TREATMENT. Sonia Di Profio,1 Claudia Milanaccio,1 Antonio Verrico,1 Marco Crocco,2 Barbara D’Ulivo,3 Flavia Napoli,4 Marcello Ravegnani,5 Natascia Di Iorgi,4 Maria Luisa Garrè. 1 The Neuroncology Unit, Istituto Giannina Gaslini, Genoa, Italy;1 The Pediatrics Department, University of Genoa, Genoa, Italy;2 The BMT Unit, Istituto Giannina Gaslini, Genoa, Italy;3 The Endocrinology Unit, Istituto Giannina Gaslini, Genoa, Italy4 and the Neurosurgery Unit, Istituto Giannina Gaslini, Genoa, Italy.5

O17. THE SECOND INTERIM REPORT OF THE MULTI-INSTITUTIONAL, PROSPECTIVE PHASE II STUDY OF RADIO-CHEMOTHERAPY FOR PRIMARY INTRACRANIAL GERMINOMAS IN JAPAN. Masao Matsutani, Ryo Nishikawa, Yutaka Sawamura, Toshiaki Kumabe, Takamitsu Fujimaki, Takaaki Yanagisawa, Jun Takahashi, Kazuhiro Sugiyama, Masahiko Nishiyama, Hidetaka Eguchi for the Japan CNS Germ Cell Tumor Study Group. Department of Neurosurgery and Neuro-Oncology, Saitama International Medical Center, Hidaka, Saitama, Japan.

O18. VALUE OF POSITIVE CEREBROSPINAL FLUID CYTOLOGY WITHOUT FURTHER MACROSCOPIC DISSEMINATION IN PATIENTS WITH INTRACRANIAL GERMINOMA. IS THERE ROOM FOR REDUCTION OF TREATMENT? Gabriele Calaminus1, Didier Frappaz,9 Claire Alapetite,5 Rolf Dieter Kortmann,3 Maria Luisa Garre,6 Umberto Ricardi, 4 Frank H. Saran, 7 Tomas Czec8 and James C. Nicholson2 on behalf of the SIOP CNS GCT Group. University Hospitals, Bonn, Germany,1 Centre Leon Berard, Lyon, France,9 Institut Curie, Paris, France,5 University of Leipzig, Leipzig, Germany,3 University of Turin, Turin, Italy,4 Gaslini Children’s Hospital, Genova, Italy,6 The Royal Marsden Hospital, United Kingdom,7 Medical University of Vienna, Vienna, Austria8 and Addenbrooke’s Hospital, Cambridge, United Kingdom.2

O19. PRELIMINARY RESULTS OF A BRAZILIAN CENTRAL NERVOUS SYSTEM GERM CELL TUMOR CONSORTIUM PROTOCOL. Andrea Cappellano,1 Jonathan L. Finlay,2 Bruna Mançano,3 Daniela Barbosa,1 Sergio Cavalheiro,1 Patricia A D'astoli,1 Frederico A Silva,1 Simone S Aguiar,4 Elvis Valera5 and Nasjla S da Silva.1 IOP/GRAACC/UNIFESP, Sao Paulo, Brazil,1 Nationwide Children’s Hospital, Columbus, Ohio, USA,2 Hospital de Cancer de Barretos, Barretos, Sao Paulo, Brazil,3 Centro Infantil Boldrini, Campinas, Sao Paulo, Brazil4 and FMRP, Riberao Preto, Sao Paulo, Brazil.5

O20. CLINICAL AND NEUROPSYCHOLOGICAL OUTCOME OF PEDIATRIC NON-MIDLINE CENTRAL NERVOUS SYSTEM GERMINOMA TREATED WITH CHEMOTHERAPY AND REDUCED DOSE/VOLUME IRRADIATION: CHILDREN’S HOSPITAL LOS ANGELES EXPERIENCE. Kee Kiat Yeo,1 Kimberly Kayser,1 Ashley Margol,1 Jessica Lenihan,1 Hung N Tran,1 Kenneth Wong,1 Nathan Robison,1 Jonathan Finlay,1,2 and Girish Dhall.1 Children's Center for Cancer and Blood Diseases, Division of Hematology, Oncology and Blood & Marrow Transplantation, Children's Hospital Los Angeles, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California1 and Nationwide Children’s Hospital and The Ohio State University, Columbus, Ohio, USA.2

O21. IMPACT ON OUTCOME OF HUMAN CHORIONIC GONADOTROPIN (HCG) ELEVATIONS ALONE IN SIOP CNS GCT 96 PATIENTS TREATED AS NON-GERMINOMATOUS/SECRETING GERM CELL TUMORS (NGGCT) – ARE WE OVER-TREATING GERMINOMA? James C. Nicholson1, Claire Alapetite5, Rolf-Dieter Kortmann3, Maria Louisa Garre6, Umberto Ricardi4, Frank H. Saran7, Tomas Czech8, Didier Frappaz9 and Gabriele Calaminus2, on behalf of the SIOP CNS GCT Group. University Hospitals, Cambridge, United Kingdom,1 Münster, Germany,2 Leipzig, Germany, 3Turin, Italy,4 Institut Curie, Paris, France,5 Gaslini Children’s Hospital, Genova, Italy, 6 the Royal Marsden Hospital, London, United Kingdom,7 Vienna, Austria, 8 and Centre Leon Berard, Lyon, France. 9

O22. SINGLE INSTITUTION EXPERIENCE WITH INTRACRANIAL GERM CELL TUMORS TREATED ACCORDING TO THE SIOP CNS GCT PROTOCOLS. Irene Slavc,1 Ulrike Leiss,1 Andreas Peyrl,1 Monika Chocholous,1 Amedeo Azizi,1 Karin Dieckmann,2 Thomas Czech,3 Departments of Pediatrics,1 Radiotherapy2 and Neurosurgery,3 Medical University of Vienna, Vienna, Austria.

ABSTRACTS BY TITLE

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O23. NATIONAL SURVEY FOR RELAPSED CENTRAL NERVOUS SYSTEM (CNS) GERM CELL TUMORS (GCT) BY THE JAPAN CHILDREN’S CANCER GROUP. Keita Terashima, 1 Masanori Yoshida 1, Ryo Nishikawa 2, Toshihiro Kumabe, 3 Fumiyuki Yamasaki, 4 Yuki Yuza, 5 Yoji Sasahara, 6 Tetsuya Takimoto 7 and Junichi Hara. 8 Children’s Cancer Center, National Center for Child Disease and Development, Tokyo, Japan,1 the Department of Brain and Spinal Cord Tumor, Saitama Medical University International Medical Center, Saitama, Japan,2 Department of Neurosurgery, Kitasato University, Minato, Tokyo, Japan,3 Department of Neurosurgery, Hiroshima University, Hiroshima, Japan,4 Department of Hematology-Oncology, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan,5 Department of Pediatrics, Tohoku University, Sendai, Japan, 6 Division of Registration and Research for Childhood Cancer, National Center for Child Disease and Development, Tokyo, Japan7and the Department of Pediatric Hematology and Oncology, Osaka City General Hospital, Osaka, Japan.8

O24. RELAPSE PATTERN AND TREATMENT OUTCOME OF RECURRENT CENTRAL NERVOUS SYSTEM GERM CELL TUMORS. Takaaki Yanagisawa, Tomonari Suzuki, Kohei Fukuoka, Jun-ichi Adachi, Kazuhiko Mishima, Ryo Nishikawa, Takamitsu Fujimaki, Masao Matsutani, Masayoshi Yamaoka, W. Oyama, Masaharu Akiyama, Yuichiro Nonaka, Yasuharu Akasaki, Yuichi Murayama. Division of Pediatric Neuro-oncology, Jikei University School of Medicine, Tokyo, Japan and the Saitama International Medical Center, Hidaka, Japan.

O25. NEW APPROACHES TO THE MANAGEMENT OF RECURRENT CENTRAL NERVOUS SYSTEM (CNS) GERMINOMA IN THE CURRENT MOLECULAR ERA. Diana S. Osorio, Jeffrey Leonard and Jonathan L. Finlay, The Neuro-oncology Program, the Division of Hematology, Oncology and BMT and the Division of Neurosurgery, The Research Institute at Nationwide Children’s Hospital and The Ohio State University, Columbus, Ohio, USA.

O26. TREATMENT AND OUTCOMES OF CENTRAL NERVOUS SYSTEM NON-GERMINOMATOUS GERM CELL TUMORS WITH EARLY RELAPSE DURING INDUCTION CHEMOTHERAPY. Hung N. Tran, Ashley Margol, Nathan Robison, Kenneth Wong, Jonathan L. Finlay and Girish Dhall. Children’s Hospital Los Angeles, Los Angeles, California, USA.

O27. NEW APPROACHES TO THE MANAGEMENT OF RECURRENT CENTRAL NERVOUS SYSTEM (CNS) MIXED MALIGNANT GERM CELL TUMORS (MMGCT) IN THE CURRENT MOLECULAR ERA. Mohamed S. AbdelBaki and Jonathan L. Finlay, Neuro-oncology Program, Division of Hematology, Oncology and BMT, Nationwide Children’s Hospital and The Ohio State University, Columbus, Ohio, USA.

O28. SEVERE CENTRAL NERVOUS SYSTEM (CNS) DAMAGE FOLLOWING HIGH DOSE IRRADIATION AND SUBSEQUENT MULTIPLE CYCLE MARROW-ABLATIVE CHEMOTHERAPY FOR PEDIATRIC/ADOLESCENT RECURRENT CNS MALIGNANT GERM CELL TUMORS. Rolla Abu-Arja,1 Girish Dhall,2 Tanya Tekautt,3 Alan Ikeda,4 Erin Murphy,3 Kenneth E. Wong2 and Jonathan L. Finlay1. Nationwide Children’s Hospital and The Ohio State University, Columbus, Ohio, USA,1 the Children’s Hospital Los Angeles and the University of Southern California, Los Angeles, California, USA,2 the Cleveland Clinic, Cleveland, Ohio, USA,3 amd the Children’s Specialty Center of Nevada, Las Vegas, Nevada, USA.4

O29. CENTRAL NERVOUS SYSTEM GERM CELL TUMORS: EXPERIENCE OF A REFERRAL CENTER IN GUATEMALA. Ana Verónica Girón1, MA Ortega1, M Castellanos1, F. Antillon1, D. Osorio2, U. Bartels.3 Unidad Nacional de Oncología Pediátrica (UNOP), Guatemala, Central América,1 Nationwide Children´s Hospital, Columbus, Ohio, United States 2 and the Hospital for Sick Children, Toronto, Canada.3

O30. NEW APPROACHES TO THE IRRADIATION-FREE MANAGEMENT OF CENTRAL NERVOUS SYSTEM (CNS) GERM CELL TUMORS (GCT) IN THE DEVELOPING WORLD. Jonathan L. Finlay and Diana S. Osorio, Nationwide Children’s Hospital and The Ohio State University, Columbus, Ohio, USA.

O31. TOWARDS NON-INVASIVE MICRORNA-BASED DIAGNOSIS AND RISK-STRATIFICATION OF CENTRAL NERVOUS SYSTEM (CNS) MALIGNANT GERM CELL TUMORS: A PROPOSED PATHWAY.Laura Esposito,1 Dawn Ward,1 Isabella Syring,2 Jorg Ellinger,2 James Nicholson,3 Nicholas Coleman,1, 4* and Matthew Murray.1, 3* The Department of Pathology, University of Cambridge, Cambridge, UK,1 the Department of Urology, University Hospital Bonn, Bonn, Germany,2 the Department of Paediatric Haematology and Oncology, Addenbrooke's Hospital, Cambridge, UK,3 and the Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK.4 *Joint senior authors.

O32. CORRELATION OF CLINICAL AND MOLECULAR ASPECTS OF CENTRAL NERVOUS SYSTEM GERM CELL TUMORS: A CLINICAL AND RESEARCH EXPERIENCE IN A COHORT SERIES IN TAIWAN. Tai-Tong Wong,1 Tsung-Han Hsieh,1 Yun-Ru Lau,1 Ting-Yu Chang,1 Yun-Yen,1 Yen-Lin Lau,1 Hsin-Lun Lee,1 Kevin Li-Chun Hsieh,1 Muh-Lii Liang,2 Robert Hsin-Hung Chan,2 Donald M Ho,2 Yi-Wei Chen,2 Feng-Chi Chen,2 Diego Shih-Chieh Lin2 and Yi-Yen Lee.2 Pediatric Brain Tumor Program, Taipei Medical University Hospital (TMUH)1 and the Pediatric Brain Tumor Study Group, Taipei Veterans General Hospital (VGH), 2 Taipei, Taiwan.

033. PD-L AND PD-1 ARE ASSOCIATED WITH TUMOR-INFILTRATING LYMPHOCYTES IN INTRACRANIAL GERMINOMA. Yoshiki Arakawa, Bin Liu, Yohei Mineharu, Masahiro Tanji, Ryuta Yokogawa, Daiki Murata, Ko-ichi Fujimoto, Nobuyuki Fukui, Yukinori Terada, Etsuko Hattori, Susumu Miyamoto, Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.

P1. DIAGNOSTIC YIELD OF SERUM AND CEREBROSPINAL FLUID TUMOR MARKERS IN PINEAL REGION TUMORS. William Gump, Division of Neurosurgery, Norton Children’s Hospital, Louisville, Kentucky, USA.

P2. THE EYES AS THE WINDOW: OPTIC ATROPHY WITH CENTRAL NERVOUS SYSTEM (CNS) GERM CELL TUMOR. Gesina F. Keating, James A. Garrity and Laurence J. Eckel. The Mayo Clinic, Rochester, Minnesota, USA.

P3. RETINAL INFILTRATION BY GERMINOMATOUS ELEMENTS FROM A PRIMARY (LOCALLY RECURRENT) CENTRAL NERVOUS SYSTEM (CNS) MIXED MALIGNANT GERM CELL TUMOR (MATURE TERATOMA WITH PURE GERMINOMA). Melissa Stalling, Lance Governale, Christopher R. Pierson, Jonathan L. Finlay, Randal Olshefski, Daniel R. Boué. Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio, USA.

P4. CENTRAL NERVOUS SYSTEM (CNS) GERMINOMA RADIOGRAPHICALLY MIMICKING GLIOMATOSIS CEREBRI. Mohammad H. Abu Arja, 1 Lisa C. Martin,2 Jerome A. Rusin,2 Daniel R. Boué3 and Jonathan L. Finlay1 and Mohamed S. AbdelBaki.1 The Divisions of Hematology, Oncology and BMT,1 Neuroradiology2 and Neuropathology,3 Nationwide Children’s Hospital and The Ohio State University, Columbus, Ohio, USA.

P5. LYMPHOCYTIC HYPOPHYSITIS WITH SUBSEQUENT FINDING OF CENTRAL NERVOUS SYSTEM GERMINOMA: A CASE REPORT. Mauricio Mesa, Maria Cynthia Fuentes, Enrique Jimenez, Rodrigo Dussan, Nicolas Useche, Juan Lammoglia, Martha Sánchez-López, Adriana Florez, Maira Soto, Juan Lopez, Victor Rozo, Dolly Díaz. Hospital Universitario Fundación Santa Fe de Bogotá. Bogotá D.C. Colombia.

P6. CLINICAL-EPIDEMIOLOGICAL CHARACTERISTICS OF CENTRAL NERVOUS SYSTEM GERM CELL TUMORS IN CHILDREN AND ADOLESCENTS AT THE EDGARDO REBAGLIATI MARTINS NATIONAL HOSPITAL DURING THE PERIOD 1998 - 2016. Elizabeth Guzmán1, Gloria Parades1, Carolina Alvarez, 1 Monica Oscanoa,1 German Posadas,2 Alejandro Yabar,3 Erika Ugarta4 and Cecilia Bonilla5. The Oncology Cancer Group, 1 Neurosurgery,2 Pathology,3 Radiotherapy4 and Endocrinology5 Programs, Edgardo Rebagliati Martins National Hospital, Lima, Peru.

ABSTRACTS BY TITLE

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P7. TREATMENT OF RECURRENT INTRACRANIAL GERMINOMA: A SINGLE INSTITUTION EXPERIENCE. Yoshiko Nakano, Yuko Ishii, Sayaka Nakamura, Kai Yamasaki, Chika Nitani, Keiko Okada, Hiroyuki Fujisaki, Hiroko Fukushima, Takeshi Inoue, Yasuhiro Matsusaka, Masahiro Tanaka, Hiroaki Sakamoto, Junichi Hara. Osaka City General Hospital, Osaka, Japan.

P8. BRENTUXIMAB-VEDOTIN MAINTENANCE FOLLOWING CHEMOTHERAPY WITHOUT IRRADIATION FOR PRIMARY SUPRASELLAR EMBRYONAL CARCINOMA IN THE SETTING OF DOWN SYNDROME. Suzanne Conley,1 Violeta Salcedo,1 Mohamed S. AbdelBaki,1 Diana S. Osorio,1 Daniel R. Boué,2 Christopher R. Pierson,2 Fahd Al-Sufiani,2 Nicholas Zumberge,3 Jeffrey Leonard4 and Jonathan L. Finlay. 1 The Divisions of Hematology, Oncology and BMT,1 Neuropathology,2 Neuroradiology3 and Neurosurgery,4 The Research Institute at Nationwide Children’s Hospital and The Ohio State University, Columbus, Ohio, USA.

SS1. SURVIVORSHIP OF CHILDHOOD CANCER. Saro Armenian, Associate Professor and Director of the Childhood Cancer Survivorship Clinic, Departments of Pediatrics and Population Sciences, City of Hope Cancer Center, Duarte, California, USA.

SS2. THE ROLE OF GENETICS AND GENETIC COUNSELING IN THE SETTING OF INTRACRANIAL GERM CELL TUMORS. Kristin Zajo and Elizabeth Varga, MS, Division of Hematology/Oncology/BMT, Nationwide Children’s Hospital, Columbus, Ohio, USA.

SS5. FERTILITY CONSIDERATIONS IN PEDIATRIC CNS GERM CELL TUMORS. Leena Nahata, 1,2 Vicky Lehmann,2 Amanda Ferrante,2 Nicole M. Caltabellotta,2 Cynthia A. Gerhardt.2 Division of Endocrinology, Nationwide Children’s Hospital, The Ohio State University College of Medicine,1 Center for Biobehavioral Health, The Research Institute at Nationwide Children’s Hospital,2 Columbus, Ohio, USA.

SS6. CEREBROVASCULAR OUTCOMES AFTER CRANIO-SPINAL RADIATION THERAPY IN BRAIN TUMOR SURVIVORS. Sabine Mueller, Pediatric Neuro-oncology Program University of California, San Francisco, California, USA.

SS8. PSYCHOSOCIAL AND QUALITY OF LIFE IN CHILDHOOD SURVIVORS OF CENTRAL NERVOUS SYSTEM (CNS) TUMORS. Tammi Young-Saleme, Director of Psychosocial Services and Program Development, Hematology/Oncology/BMT, Nationwide Children's Hospital, Columbus, Ohio, USA.

SS9. REHABILITATION CONSIDERATIONS IN PATIENTS WITH CNS GERM CELL TUMORS. Nathan S. Rosenberg, MD, Division of Rehabilitation Medicine, Nationwide Children’s Hospital, Columbus, Ohio, USA.

SS10. HEARING OUTCOMES IN CENTRAL NERVOUS SYSTEM (CNS) GERM CELL TUMORS. Kristin Knight, Oregon Health and Science University (OHSU), Portland, Oregon, USA.

SS11. SECOND CANCERS FOLLOWING TREATMENT OF CENTRAL NERVOUS SYSTEM (CNS) GERM CELL TUMORS. Randal Olshefski MD, Director Survivorship Clinic, Nationwide Children’s Hospital, Columbus, Ohio, USA.

ABSTRACTS BY TITLE

AbdelBaki, MS ..................................................O2, O27, P4, P8Abu Arja, MH ......................................................................... P4Abu-Arja, R .......................................................................... O28Adachi, J .......................................................................O9, O24Aguiar, SS ............................................................................. O19Akasaki, Y ............................................................................ O24Akiyama, M ......................................................................... O24Alapetite, C .................................................................O18, O21Allen, JC .................................................................................K4Al-Sufiani, F ............................................................................ P8Alvarez, C ................................................................................ P6Alves, CA ............................................................................... O6Amatruda, JF ........................................................................K20Antillon, F............................................................................ O29Arakawa, Y ........................................................................... O33Arita, K ................................................................................ O10Armenian, S .......................................................................... SS1Ateek, C ................................................................................K20Azizi, A ................................................................................ O22Barbosa, D ........................................................................... O19Barnholtz-Sloan, J ...................................................................K1Bartels, U ....................................................................O14, O29Bedard, P ............................................................................. O14Bertoluzzo, L .........................................................................K13Biassoni, V ........................................................................... O13Blüml, S ................................................................................. O5Bonilla, C ................................................................................ P6Boué, DR ....................................................................P3, P4, P8Bouffet, E ............................................................. K12, O1, O14Cai, L ................................................................................... O12Calaminus, G ..............................................................O18, O21Caltabellotta, NM ................................................................. SS5Cama, A ........................................................................ K13, O6Cappellano, A ...................................................................... O19Carrie, C ................................................................................ O3Caruso, P ............................................................................... O7Castellanos, M ..................................................................... O29Cavalheiro, S ........................................................................ O19Chan, RHH ......................................................................... O32Chang, TY ........................................................................... O32Chen, FC ............................................................................. O32Chen, KS ..............................................................................K20Chen, YW ............................................................................ O32Chen, Z ................................................................................K17Cheng, J ................................................................................. O2 Cheng, S .............................................................................. O14Chin, JY ................................................................................. O7Chocholous, M .................................................................... O22Coleman, N ......................................................................... O31

Conklin, H .......................................................................... O15Conley, S ................................................................................. P8Conter, CF ............................................................................. O3Crocco, M ............................................................................ O16Czech, T .............................................................O18, O21, O22da Silva, NS .......................................................................... O19Dang, J ................................................................................. O14D'astoli, PA .......................................................................... O19DeMasters, BK ......................................................................K21Dhall, G ............................................ O2, O11, O20, O26, O28Di Iorgi, N ........................................................................... O16Di Profio, S .......................................................................... O16Díaz, D ................................................................................... P5Dieckmann, K ...................................................................... O22Diletto, B ............................................................................. O13D'Ulivo, B ........................................................................... O16Dussan, R ................................................................................ P5Eckel, LJ.................................................................................. P2Eguchi, H ............................................................................ O17Ellinger, J ............................................................................. O31Esposito, L ........................................................................... O31Farr, J ................................................................................... O15Feldman, DR ........................................................................K14Ferrante, A ............................................................................ SS5Finlay, JL ............................................ O2, O8, O19, O20, O25, O26, O27, O28, O30, P3, P4, P8Florez, A .................................................................................. P5Frappaz, D ...........................................................O3, O18, O21Frazier, AL ....................................................................K11, K20Fuentes, MC ........................................................................... P5Fujimaki, T ..........................................................O9, O17, O24Fujimoto, K ......................................................................... O33Fujisaki, H .............................................................................. P7Fukui, N .............................................................................. O33Fukuoka, K .......................................................................... O24Fukushima, H ......................................................................... P7Fukushima, S ........................................................................K18Fustin, NJ .............................................................................K20Gajjar, A ............................................................................... O15Gandola, L ........................................................................... O13Garrè, ML ..........................................K13, O6, O16, O18, O21Garrity, JA ............................................................................... P2Gerhardt, C ........................................................................... SS5Girón, AV ............................................................................ O29Goddard, K ...................................................................O1, O14Goebel, CP ............................................................................ O7Governale, L ............................................................................ P3Gump, W ................................................................................ P1Guzmán, E .............................................................................. P6

AUTHOR INDEX

PAGE | 32 PAGE | 33

Hara, J ...........................................................................O23, P7Hattori, E ............................................................................. O33Haupt, R ...............................................................................K13Ho, DM ............................................................................... O32Hodgson, D ..................................................................O1, O14Hong, W .............................................................................. O12Hsieh, KLC .......................................................................... O32Hsieh, TH ............................................................................ O32Hukin, J ........................................................................O1, O14Ichimura, K ................................................................... K18, O4Ikeda, A ................................................................................ O28Indini, A .............................................................................. O13Inoue, T .................................................................................. P7Ishii, Y ..................................................................................... P7Jalai, R ..................................................................................K16Jimenez, E ............................................................................... P5Jones, M ............................................................................... O11Kanamori, M ......................................................................... O4Kapur, P ................................................................................K20Kayser, K .............................................................................. O20Keating, GF ............................................................................ P2Knight, K ............................................................................ SS10Kobayashi, Y .......................................................................... O9Kortmann, RD ............................................................O18, O21Kumabe, T ..................................................................O17, O23Kurisu, K ............................................................................. O10Kuzuoka, S ............................................................................K18Laetsch, T .............................................................................K20Lai, M .................................................................................. O12Lammoglia, J ........................................................................... P5Laperriere, N .................................................................O1, O14Lau, CC ..................................................................................K2Lau, YL ................................................................................ O32Lau, YR ................................................................................ O32Lee, HL ................................................................................ O32Lee, YY ................................................................................. O32Lehmann, V .......................................................................... SS5Leiss, U ................................................................................ O22Lenihan, J ............................................................................ O20Leonard, J ........................................................O2, O8, O25, P8Li, J ...................................................................................... O12Li, Y ..................................................................................... O15Liang, ML ............................................................................ O32Lin, DSC ............................................................................. O32Liu, B ................................................................................... O33Lo, A .............................................................................O1, O14Looijenga, LHJ......................................................................K20Lopez, J ................................................................................... P5Lum, L ..................................................................................K20

MacDonald, SM .................................................................... O7Mançano, B .......................................................................... O19Mardis, ER ............................................................................K22Margol, A ....................................................................O20, O26Martin, LC .............................................................................. P4Massimino, M ...................................................................... O13Matsusaka, Y ........................................................................... P7Matsutani, M ...............................................K6, K18, O17, O24McKenzie, M ......................................................................... O1Merchant, TE ................................................................ K8, O15Mesa, M .................................................................................. P5Milanaccrio, C .............................................................. K13, O6Mineharu, Y ......................................................................... O33Mishima, K ...................................................................O9, O24Miyake, Y ............................................................................... O9Miyamoto, S ........................................................................ O33Morana, G .................................................................... K13, O6Morley, SS ...............................................................................K1Mottolese, C .......................................................................... O3Mueller, S .............................................................................. SS6Murata, D ............................................................................ O33Murayama, Y ........................................................................ O24Murphy, E ............................................................................ O28Murray, M ............................................................................ O31Nahata, L .............................................................................. SS5Nakamura, S ........................................................................... P7Nakano, Y ...................................................................... K18, P7Napoli, F .............................................................................. O16Nelson, MD ........................................................................... O5Nicholson, J ................................................O1, O18, O21, O31Nishikawa, R ........................ K7, K18, O4, O9, O17, O23, O24Nishiyama, M ...................................................................... O17Nitani, C ................................................................................. P7Nonaka, Y ............................................................................ O24Nozza, P ................................................................................. O6Okada, K................................................................................. P7Olch, A ................................................................................ O11Olshefski, R .................................................................. P3, SS11Ortega, MA .......................................................................... O29Oscanoa, M ............................................................................. P6Osorio, DS ...................................................O25, O29, O30, P8Oyama, W ........................................................................... O24Parades, G ............................................................................... P6Pecori, E ............................................................................... O13Pedone, C............................................................................... O3Peet, AC ..................................................................................K5Peyrl, A ................................................................................ O22Pierson, CR .......................................................................P3, P8Posadas, G ............................................................................... P6

AUTHOR INDEX

Qiu, X .................................................................................. O12Rakheja, D ............................................................................K20Ramenghi, L .........................................................................K13Ranalli, MA ..........................................................................K15Rapalino, O ........................................................................... O7Ravegnani, M ....................................................................... O16Ricardi, U ...................................................................O18, O21Robison, N ..................................................................O20, O26Rosenberg, NS ...................................................................... SS9Rossi, A ......................................................................... K13, O6Rozo, V ................................................................................... P5Rusin, JA ................................................................................. P4Saito, R .................................................................................. O4Sakamoto, H ........................................................................... P7Salcedo, V ............................................................................... P8Sánchez-López, M ................................................................... P5Sands, SA ..............................................................................K10Saran, FH ....................................................................O18, O21Sasahara, Y ........................................................................... O23Savir, G .................................................................................. O7Sawamura, Y ........................................................................ O17Schiavello, E ......................................................................... O13Scott, S ................................................................................. O15Sethi, RV ................................................................................ O7Severino, MS .......................................................................... O6Shan, C ................................................................................ O12Shukla, AA ............................................................................K20Silva, FA ............................................................................... O19Sklar, CA .................................................................................K9Slavc, I ................................................................................. O22Soto, M ................................................................................... P5Srinivasan, S ......................................................................... O15Stalling, M .............................................................................. P3Stuart, S ................................................................................K20Sugiyama, K ................................................................O10, O17Surani, A ...............................................................................K19Suzuki, T .......................................................................O9, O24Syring, I ............................................................................... O31Szathmari, A ........................................................................... O3Takahashi, J .......................................................................... O17Takami, H ..................................................................... K18, O4Takimoto, T ......................................................................... O23Tamrazi, B .............................................................................. O5Tanaka, M ............................................................................... P7Tanji, M ............................................................................... O33Tarbell, NJ ............................................................................. O7Tekautt, T ............................................................................ O28Terada, Y .............................................................................. O33Terashima, K ........................................................................ O23

Thiesse, P ............................................................................... O3Tinkle, CL ........................................................................... O15Toll, S................................................................................... O11Tominaga, T ........................................................................... O4Tonse, R ................................................................................K16Torkildson, J .......................................................................... O2 Tortora, D .............................................................................. O6Tran, HN ....................................................................O20, O26Tyldesley, S ........................................................................... O14Uchida, E ............................................................................... O9Ugarta, E ................................................................................. P6Useche, N ............................................................................... P5Valera, E ............................................................................... O19Varga, E................................................................................. SS2Verrico, A ......................................................................O6, O16Walker, D ................................................................................K3Wang, L ............................................................................... O12Wang, RX .............................................................................. O2 Ward, D ............................................................................... O31Wong, KE ......................................... O2, O11, O20, O26, O28Wong, TT ............................................................................ O32Yabar, A ................................................................................... P6Yamaguchi, K ........................................................................K20Yamaoka, M ......................................................................... O24Yamasaki, F .................................................................O10, O23Yamasaki, K ............................................................................. P7Yanagisawa, T .......................................................O9, O17, O24Yen, Y ................................................................................... O32Yeo, KK ................................................................................ O20Yock, T ............................................................................O2, O7 Yokogawa, R ......................................................................... O33Yoshida, EJ ........................................................................... O11Yoshida, M ........................................................................... O23Young-Saleme, T ................................................................... SS8Yuza, Y ................................................................................. O23Zajo, K .................................................................................. SS2Zhang, P .............................................................................. O12Zhou, J ................................................................................. O12Zumberge, N .......................................................................... P8

PAGE | 35

SYMPOSIUM COMMITTEES

SYMPOSIUM CHAIR Jonathan L. Finlay (United States)

SYMPOSIUM CO-CHAIRS Arnab Chakravarti (United States)Jeffrey R. Leonard (United States)

INTERNATIONAL SCIENTIFIC COMMITTEEJill Barnholtz-Sloan (United States)Ute Bartels (Canada)Eric Bouffet, (Canada)Gabriele Calaminus (Germany)Andrea Cappellano (Brazil)Zhong-ping Chen (China)Girish Dhall (United States)Jason Fangusaro (United States)Sharon L. Gardner (United States)Koichi Ichimura (Japan)Rakesh Jalali (India)Stewart J. Kellie (Australia)Soumen Khatua (United States)Ching C. Lau (United States)Thomas E. Merchant (United States)Matthew J. Murray (United Kingdom)Marvin D. Nelson (United States)James C. Nicholson (United Kingdom)Roger J. Packer (United States)Ibrahim Qaddoumi (United States)E. Steven Roach (United States)Jerome A. Rusin (United States)Stephen A. Sands (United States)Charles A. Sklar (United States)Mark M. Souweidane (United States)Tai-Tong Wong (Taiwan)

LOCAL ORGANIZING COMMITTEEDaniel BarrTami DavisJennifer EnglishNichole FerrisConnie HieattSulema LewisNichole OocummaRobert ShepherdTammi Young-Saleme

PAGE | 36 PAGE | 37

LIVELY URBAN ENTERTAINMENT DISTRICTSConvention attendees are right in the middle of “Five on High” – the five-mile span of High Street connecting downtown’s districts – packed with entertainment, restaurants and shops. Many of Columbus’ unique neighborhoods are accessible on foot, including the cool galleries of the Short North Arts District, awesome architecture of Victorian Village, named one of America’s most beautiful neighborhoods by Thrillist, and the energetic crowds of the Arena District. Venture north, and you’ll find yourself in The Ohio State University District. Or, take a short CBUS ride south to check out quaint and historic German Village, with a stop in the Brewery District along the way.

WORLD-CLASS ARTS & CULTUREThe city’s art scene is bursting with creativity, leading it to be named one of the “30 Most Fun Places to Live in the U.S.” by U.S. News & World Report and one of “17 Must-Visit Destinations in 2017” by Expedia. Check out Shadowbox Live!, America’s largest resident theater company, don’t miss the world-class visual art at the Columbus Museum of Art, take in what ARTNews calls one of the top art collections in the world at The Pizzuti Collection or view the largest collection of local artists just by walking the halls of the Greater Columbus Convention Center.

A FOODIE’S PARADISEAs Food Republic said, “If you can’t find excellent places to eat in Columbus, you’re no food enthusiast.” There are more than 100 restaurants within walking distance of the convention center alone, including the North Market, where you’ll find an array of fresh and prepared foods. Explore the Columbus Ale and Coffee Trails, and don’t miss Columbus-based Jeni’s Splendid Ice Creams, from well-known James Beard Award-winning cookbook author Jeni Britton Bauer, called one of the best ice cream spots in the U.S. by Food & Wine.

FASHION-FORWARDColumbus has the third-highest concentration of fashion designers in the country, behind New York and Los Angeles. Hit up the Short North’s eclectic boutiques or check out Easton, dubbed the “Rodeo Drive of the Midwest” by USA Today. To this day, Easton serves as a blueprint for the modern shopping center thanks to the brilliant minds behind it, including Les Wexner, founder of L Brands (Victoria’s Secret, Bath & Body Works, etc.), one of five Fortune 500 companies headquartered in Columbus.

TOP-RANKED ATTRACTIONSHang out in the Heart of Africa at “Jungle” Jack Hanna’s home zoo, the Columbus Zoo and Aquarium. Get hands-on at COSI, the top ranked science center loved by kids and adults of all ages. Check out Franklin Park Conservatory and Botanical Gardens, the only botanical garden in the world with a permanent collection of glass artwork by Dale Chihuly. Let loose a little at Eldorado Scioto Downs or Hollywood Casino Columbus.

experiencecolumbus.com

COLUMBUS WELCOMES

Come find out why Columbus ranked “Highest in Visitor Satisfaction in the Midwest” by J.D. Power* in the 2016 Destination Experience Satisfaction Study.

*Columbus, OH received the highest numerical score among 8 cities in the Midwest in the J.D. Power 2016 Destination Experience Satisfaction Study, based on 26,124 total responses, measuring the experiences and perceptions of travelers who visited a top 50 U.S. destination, surveyed February-July 2016. Your experiences may vary. Visit jdpower.com.

Columbus, the 15th largest city in the country (right behind San Francisco), as well as the largest and fastest-growing city in Ohio, is a smart and open community whose dynamic convention package fits the needs of every attendee. Located within a one-day drive or one-hour flight from more than half of the U.S. Population, Ohio’s state capital is easily accessible for all.

Upon arrival, attendees love exploring the place that is fast becoming known as one of the nation’s most creative, forward-thinking and exciting cities. Celebrated for its incredible arts, entertainment, fashion and culinary offerings; exciting collegiate and professional sports teams and events; and spectacular riverfront with a sprawling ribbon of parkland on the Scioto Mile through downtown, this city on the move has something for everyone.

The 5th International CNS Germ Cell Tumor Symposium

STILL CURIOUS?• Columbus won the $40 million U.S. Department of Transportation Smart City Challenge.

• The Washington Post calls Columbus the “new destination for food lovers.”

• Time has named Columbus among the country’s top big cities and best places to live for millennials.

• According to Forbes, Columbus is the #1 opportunity city in the country.

It’s our pleasure to assist you with an amazing Columbus experience. To learn more, visit experiencecolumbus.com, follow us on Twitter @expcols or find us on Facebook.

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SHORT NORTH ARTS DISTRICTEclectic. Art. Boutiques. Local Dining. Gallery Hop.

DOWNTOWNState Capitol. Historictheatres. Attractions.Columbus Commons. Riverfront.

UNIVERSITY DISTRICT

THE ARENADISTRICT

GERMANVILLAGE

Resource. Music. Campus. Late night.

Sports. Restaurants. Live music. Nightlife.

Historic architecture.Brick streets. Dining.Boutiques.

GREATER COLUMBUS CONVENTION CENTERNewly renovated. Events destination. Modern landmark.

COLUMBUS HIGH FIVE | Five miles. Five entertainment districts. Free downtown circulator.

RESPECTED SPORTS SCENE

The Arena District is home to NHL’s ColumbusBlue Jackets as well as The Columbus Clippers, Triple-A baseball affiliate of the Cleveland Indians, whose home stadium, Huntington Park, was named “Ballpark of the Year” four times in its first six years of operation. Nearby, MLS’ ColumbusCrew SC play at MAPFRE Stadium, the first soccer-specific stadium built in the country. Columbus is also home to The Ohio StateBuckeyes, winners of the first College Football Playoff National Championship and the JackNicklaus Museum, a tribute to the Columbus native and golf legend.

GETTING HERE AND AROUND John Glenn Columbus International Airport offers nonstop service to 33 destinations and is just eight miles or 10 minutes from downtown, a short ride on COTA’s AirConnect. Once downtown, hop on the free CBUS circulator or use alternative transportation services such as Uber, Lyft, CoGo (bike-sharing) and Car2Go to explore beyond the city limits.

CMH RouteLCK RouteCMH & LCK Route

Flight Time

Drive Time

AirConnect | Express bus service runs between John Glenn International, the Greater Columbus Convention Center (GCCC) and downtown hotels. The connector stops at baggage claim every 30 minutes and costs $2.75 each way.

CBUS | The Central Ohio Transit Authority (COTA) operates bus service in Columbus. The CBUS is a free downtown circulator that runs every 10-15 minutes from the Short North Arts District in the north to the Brewery District/German Village in the south, with stops at many popular downtown locations along the way.

PAGE | 38 PAGE | 39

SHORT NORTH ARTS DISTRICT

LincolnTheatre

HuntingtonPark

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The King ArtsComplex

TopiaryPark

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MetroPark

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The Cap at Union Station

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Downtown Restaurants cONVENTION cENTER vicinity

TELL US HOW COLUMBUS IS DOINGTake this 1-minute survey MYCOLUMBUSEXPERIENCE.ORG

ARENA DISTRICT1. 89 Fish & Grill, 614-586-4585, $$$ D2. bd’s Mongolian Grill, 614-586-0077, $$ L,D3. Bar Louie, 614-220-0900, $$ L,D4. Boston’s The Gourmet Pizza, 614-229-4275, $$ L,D5. Buca di Beppo, 614-621-EATS, $$ L,D6. Callahan’s Irish Tavern, 614-223-1200, $ D. Closed Mon.7. Gordon Biersch Brewery Restaurant, 614-246-2900,$$$ L,D8. Max & Erma’s, 614-228-5555, $$ B,L,D9. Nada, 614-715-8260, $$ L,D10. North Market, 614-463-9664, Public market with food vendors including Jeni’s Splendid Ice Creams, Bubbles tea and juice company, Hot Chicken Takeover, Stauf’s, and Taste of Belgium. $ B,L,D11. Park Street Patio, 614-975-1363, $ D Open Thur.-Sat. only.12. R Bar Arena, 614-221-4950, $ L,D13. Rodizio Grill, 614-241-4400, $$$$ L,D 14. Studio Movie Grill Arena Grand, 614-469-5000, $$ L,D15. Sunny Street Cafe, 614-222-3008, $ B,L (Dinner on event nights at Nationwide Arena)16. The Three-Legged Mare, 614-222-4950, $$ L,D

SHORT NORTH ARTS DISTRICT17. Bareburger, 614-706-4760, $$ L,D 18. Barley’s Brewing Company, 614-228-ALES, $$ L,D19. Black Point, 614-221-5294, $$$$ D20. Convention Center, 614-645-5000, All American Hamburgers; Charley’s Grilled Subs; Chicken ’n Eggs; Donatos Pizza; Einstein Bros Bagels; Fame’s Diner; Goodrich Ice Cream; JaVa’s Cyber Espresso Bar; Mykonos Gyros; Noble Roman’s; Siam; Subway; Tony J’s Mexican Grill. $21. Denmark, 614-914-6700, $$ D Closed Sun.22. Double Comfort, 614-745-2183, $$ L, D Closed Mon., Brunch only on Sun. 23. Eleven, 614-225-9611, $ D Closed Sun.24. Gallerie Bar & Bistro, 614-484-5287, Inside Hilton Columbus Downtown, $$$$ B,L,D 25. The Guild House, 614-280-9780, $$$ B,L,D26. Hyde Park Prime Steakhouse, 614-224-2204, $$$$ D27. Japanese Steak House, 614-228-3030, $$$ L,D Sat. dinner only. Closed Sun.28. Lemongrass Fusion Bistro, 614-224-1414, $$$ L,D29. Marcella’s, 614-223-2100, $$$ D30. Martini Modern Italian, 614-224-8259, $$$ D31. The Pearl Restaurant, Tavern & Oyster Room, 614-227-0151, $$$ D, Brunch Sat.-Sun. downtown32. Flatiron Bar & Diner, 614-461-0033, $ L,D Sat. dinner only. Closed Sun.33. Wolf’s Ridge Brewing, 614-429-3936, $$$ B,L,D

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TOWN ST

SPRING ST

E GAY STCOTA CBUS Free public bus service circulating through the Short North Arts District to the north and the Brewery District to the south.

Hours of operation: Mon.-Thur., 7 a.m.-9 p.m.; Fri., 7 a.m.-12 a.m.; Sat., 9 a.m.-12 a.m.; Sun., 10:30 a.m.-6 p.m. Convention Center area stops show above.

catch the cbus

2

Restaurants - Downtown AreaSHORT NORTH ARTS DISTRICT34. Arch City Tavern, $$ D35. Basi Italia, $$$ D Closed Sun. and Mon.36. Bernard’s Tavern, $$ L,D37. Bodega, $$ L,D38. Cookie Cravings Bakery, $ B,L Closed Sun.39. Cray Eatery & Drinkery, $ L,D 40. Donatos Pizza, $ L, D 41. Hubbard Grille, $$$ D Open L on Sat.42. Impero Coffee, $43. Jeni’s Splendid Ice Creams, $44. Katalina’s Cafe Corner, $ B,L,D45. Late Night Slice/Quick Slice, $ D46. Melt Bar & Grilled, $$ L,D47. North High Brewing, $ L, D48. Northstar Cafe, $$ B,L,D49. Press Grill, $$ L,D50. Rigsby’s Kitchen, $$$ D. Closed Sun.51. Short North Pint House and Beer Garden, $$ D Sat.-Sun. lunch.52. Spinelli’s Deli, $ B,L,D53. Tasi Cafe, $$ B,L,D54. White Castle, $ B,L,D 55. Wine on High, $56. zpizza, $$ L,D

DOWNTOWN57. The Boat House at Confluence Park, $$ D 58. Columbus Commons Food Truck Food Court, $ L Thur. only thru Oct.59. Cup ’O Joe Downtown, $ B,L Dinner Thur.-Fri. Closed weekends.60. Dempsey’s Restaurant, $$$ B,L,D. 61. de-NOVO bistro & bar, $$$$ B,L,D62. Dirty Frank’s Hot Dog Palace, $ L,D63. Donatos Pizza, $ L, D64. Elevator Brewery & Draught Haus, $$$ L,D Sat.dinner only. Closed Sun. 65. Grass Skirt Tiki Room, $$ L, D Closed Sun66. High Street Grill, inside The Westin Columbus, $$ B,L,D67. The Hungry Soul Cafe $$ B, L, D Closed Sat.-Sun. 68. M, $$$$ D Closed Sun. 69. Milestone 229, $$ L,D 70. PurePressed Juicery, $$ B, L Closed Sun. 71. Tommy’s Diner, $ B,L

GAY STREET DISTRICT72. Cafe Brioso, $ B,L Closed Sun. 73. The Carvery, $ L, Closed Sun.74. Due Amici, $$ L,D75. Latitude 41, inside the Columbus Renaissance. $$$ B,L,D76. Mitchell’s Steakhouse, $$$$ L,D Sat.-Sun. dinner only.77. Tip Top Kitchen and Cocktails, $ L,D

GERMAN VILLAGE/ BREWERY DISTRICT78. Barcelona Restaurant, $$$ L,D Sat.-Sun. dinner only.79. Brick, $$ L, D Sat. dinner only. Closed

SHORT NORTH ARTS DISTRICT

LincolnTheatre

HuntingtonPark

-

The King ArtsComplex

TopiaryPark

Spruce St

Ohio Judicial Center

Scio

to M

ile

SciotoAudubon

MetroPark

ShadowboxLive

Franklin ParkConservatoryand Botanical

Gardens

The Cap at Union Station S Th

ird St

Mo

haw

k Ave

Jaeger St

S Gran

t Ave

GERMAN VILLAGE W Whittier St

Schiller Park

GAY STREETDISTRICT

ColumbusCommons

N H

igh St

= COTA CBus Route-

4

Upd

ated

Jun

e 26

, 201

4

6

Downtown Columbus

59

Sun. and Mon. 80. Columbus Brewing Company, $$ L,D Sat. dinner only. Closed Sun.81. Claddagh Irish Pub, $$ L, D82. Stauf’s Coffee, $ B,L,D83. G. Michael’s Italian-American Bistro & Bar, $$$$ D84. Harvest Pizzeria, $$, L,D Mon. dinner only. Closed Sun.85. Jeni’s Splendid Ice Creams, $86. Juergen’s German Village Bakery and Restaurant, $ B,L,D Closed Mon. 87. Katzinger’s Delicatessen, $ B,L,D88. Kittie’s Hand Crafted Cakes, $ B, L, Closed Mon. & Tue.

89. Kolache Republic,$ B, L90. Lindey’s, $$$ L,D91. Pistacia Vera, $ B,L,D Closed Mon.92. Schmidt’s Restaurant und Sausage Haus, $$ L,D 93. Schmidt’s Fudge Haus and Gifts, $$94. Skillet, $$ L,D Sat.-Sun. brunch only. Closed Mon-Tues.95. The Sycamore, $$$ L, D Brunch Sat. Closed Sun. 96. The Thurman Café, $ L,DNEARBY97. The Angry Baker, $ B,L98. Buckeye Hall of Fame Grille, $$ L, D

-= COTA CBus Route

71

98 99

experiencecolumbus.com

100

44 38

393552

57

7980

88 84878382

869190 95

93 92

85

78

96

94

81

89

67

65

62 63666068

69

59

61

64

7274 77

76 7573

374554

4856

43

505336

42554149

4034

4651

SEE REVERSE FOR CONVENTION CENTER

VICINITY RESTAURANTS

70

Average dinner entrée price: $ = under $10$$ = $10-$15, $$$ = $15-$20 $$$$ = $20+

B= breakast; L= lunch; D= dinner Stops along the Columbus Coffee Trail are

indicated in blue (cbuscoffee.com).Stops along the Columbus Ale Trail are indicated in

orange (cbusaletrail.com)

Updated May 5, 2015

99. Hofbrauhaus Columbus, $$ L, D100. Miller’s Columbus Ale House, $$ L,D101. The Top Steak House, $$$$ D

47

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97

101

PAGE | 40 PAGE | 41

NOTES

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NOTES

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