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Jungwirth et al. Suppl. Fig. 1. A. B. Jungwirth et al. Suppl. Fig. 2. A. HCT-116. A549. - +. - +. KP46. B. Bax. 4 hours 15 hours. Bim EL. KP46 (µM) 0 2.5 10 2.5 10. C. M C M C M C M C M C. Bak. Prohibitin. b -actin. Bcl-2. - PowerPoint PPT Presentation
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Jungwirth et al. Suppl. Fig. 1
p53 wt p53 mut or ko0
1
2
3
4
5 ns
A549
HCT-116 p53wt
SW480A427
HCT-116 p53ko
KP
46 IC
50 (
µM
)A
B
0 11.
25 10 0 11.
25 100
5
10
15
A427HCT-116
KP46 (µM)
Cel
l wit
h d
epo
lari
zed
mit
och
on
dri
a (%
)
Jungwirth et al. Suppl. Fig. 2
HCT-116
b-actin
Bim EL
Bak
Bax
- + KP46A549
- + A
C
0 100
1
2
3
4HCT-116HCT-116 bax/ko *
KP46 (µM)
-fol
d ch
ange
inA
nnex
in V
+ ce
lls
KP46 (µM) 0 2.5 10 2.5 104 hours 15 hours
M C M C M C M C M C
GADPH
Prohibitin
Bax
Bcl-2
B
DAPI F-actin
Integrin b1 merged
DAPI F-actin
Integrin b1 merged
DAPI F-actin
Talin merged
DAPI F-actin
Talin merged
control KP46
Jungwirth et al. Suppl. Fig. 3
A
B
C
KP46 (µM) 0 10 0 10
HOS
b-actin
Integrin b1
MG63
time (hours) 0 3 6 0 3 6 0 3 6
A549
b-actin
Integrin b1
SW480A427
Jungwirth et al. Suppl. Fig. 4
10µM KP46
Time (min)0 10 20 30 40
F34
0nm
/F38
0nm
0.0
0.2
0.4
0.6
0.8
1.0
1µM Ionomycin
Time (min)0 2 4 6 8 10
F34
0nm
/F38
0nm
0.0
0.5
1.0
1.5
2.0
2.5
A427
1 2 3 4 50.00
0.25
0.50
0.75
1.00
1.25 - E-64+ E-64
******
KP46 (µM)
-fo
ld s
urv
ival
HCT-116
0 1 2.5 5 100.00
0.25
0.50
0.75
1.00
1.25
KP46 (µM)
-fo
ld s
urv
ival
Jungwirth et al. Suppl. Fig. 5