K11 - PHARMCOSOCIAL-1

8/10/2019 K11 - PHARMCOSOCIAL-1

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PHARMCOSOCIAL 1

Wahyu dwi k

Departement of Pharmacology and TherapyMedical School Unsoed


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LEARNING TOPICS

Drug Information Resources

Drug regulation : organization and

control Drug Use in Health Service Center


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LEARNING OBJECTIVE

Student able to explain :

Drug information : various and resources

Benefit and leak of every druginformation

The standard requarement have to befulfilled by an advertisement

How to search the drug information Drug management in development

country


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VARIOUS OF DRUGS INFORMATION

(Resources and Form)

Non-commercial

Commercial


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Non Commercial Drug Information

WRITING VERBAL OTHERS

Handbooks

Textbook

Pharmacist Video cassette

Therapeuticguidelines

Advancelearning

Disc of DrugInfo

Drugs infobulletin

Symposium Info servicecenter

Formulary Other medicalpractician

Medical

magazine


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Commercial Drug Information

WRITING VERBAL OTHERS

Handbooks

Textbook

Medical

representatives

Video cassette

Advertisement Symposium Discs of DrugInfo

Special letter of

Drugs info


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BENEFIT AND LEAK

DRUGS INFORMATION RESOURCES

NON COMMERSIAL


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TEXTBOOK-HANDBOOK

The main info to learn deeply

There are :

Book of drug (to learn characteristic of

pharmacology, pharmacokinetic,pharmacodynamic, adverse effect)

Book of therapeutic (begin to clinical problems)

Important : revise frequently (according

to drug info development) Handbook : good if just has limited time

to read.


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REFERENCE BOOKS

Some of them good for guidance.

According to expert aggrimment :

Therapeutic guideline The guidance of antibiotic use

Ect

Applied in local, national,international


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Bulletin of Drug and Therapeutic

Periodical (un-charge) Info about promotion of drug use and

therapeutic rationally.

Objective info Assessment for drug benefit and safety Recommendation to apply in clinical practice

Ex : Australian prescriber (Australia) Drug and therapeutic bulletin (UK)

Prescrire (Franc) Drug Information Newsletter (Singapore) Lembaran obat dan pengobatan (Indonesia)


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MEDICAL MAGAZINES

There are General Medical Magazine

Lancet

BMJ, AMJ Special Medical Magazine

Tubercule

American Journal Of Respiratory Diseases

Journal of Gastroenterology

Be careful: a lot of research resultapposite each other (For clinicalapplication need to re-research/independent research)


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VERBAL & MULTIMEDIA

Drug information center in hospital

E-drug info : internet, e-mail, disc

Quick, practice but more expensive


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BENEFIT AND LEAK

DRUGS INFORMATION RESOURCES

COMMERSIAL


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Commercial Drug Information

Pharmaceutical Industry

Simply, clear and easy to be understood.

Not objective : positive info >>

Purpose to support drug selling

By involving : symposium, article inhealth magazine that support by

pharmaceutical Industry Difficult to control and re-check of the

truth


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ADVERTISEMENT

Fast to reach medical service (Hospital, doctor)

A lot of them were out of guideline (WHO,1988)

Name of active substance (international Non-proprietary Names=INN) and trade name

Form Dosage and administration

Indication

Adverse effect (safety)

Precaution and contra-indication

Drug interaction Referencies

Name and adress of manufacture


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PRODUCT INFO

Together with drug cover

For user info

Can be believed and under-controlby Health Department RI.

Simply, complete info, withoutcommersial messages.

But often be forgotten (not be givento the patient


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PRODUCT INFO

The component :

INN (generic name of active substance)

Pharmacologic info (effect, work mechanism,

pharmacokinetic) Clinical info (indication, dosage regiment,

contra-indication, precaution, adverse effect,drug interaction and over-dosage)

Pharmaceutical info (form, strength, storage,

expire date, drug classification, manufacturename, vehikulum


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THE OTHER RESOURCES

IIMS

ISO

Symposium Seminar

Research report

Medical journal


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How to search the drug information


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SELECTION TO DRUG INFO

RESOURCES

Pharmacologic characteristic Textbook and handbook

Adverse effect American Medical Association (AMA)

Drug Evaluation

Dukes MNG (1998) Meylers Side Effectof Drugs, 11thEdition, Elsevier, oxford

Drug ingridient IIMS, ISO dll


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SELECTION TO THERAPEUTIC INFO

RESOURCES

Drug of choice and its alternative drugfor various diseases

Current medical Diagnosis & Treatment

Current pediatric Diagnosis & Treatment

Drug use in special groups (condition)

Local therapeutic guide

Australian drug evaluation committee (1989),

medicines in pregnancy Hand book : clinical pharmacokinetik

Ect.


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DRUG IN DEVELOPMENT COUNTRY

Regulation and Use

Why is It important to be known ?


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IMPORTANT ISSUES

Despite the availability of many effective drugs onthe world market.

Many development country still do not have regularaccess to the most needed essential medicines.

Medically ineffective and economically inefficientuse of pharmaceuticals by both healthcareproviders and consummers is commonlyencounter in many communities

Increasing problems of counterfeit and

substandard drugs in many parts of thedevelopment world.

Improvements in the supply, distribution, and useof pharmaceuticals are possible.


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DRUG SITUATION IN DEVELOPMENT COUNTRY

(DArcy, 1984)

Inadequate funds to maintain constantsupply

Prices are too high

No foreign exchange for buying drugs orraw material

Inefficient transport and distribution

Drug deterioration in the central medical

stores or during transport Lack of government commitment for the

health and pharmaceuticals sectors


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Action Needed for improving and

Maintaining sustainable financing of Drug

Efficiency in pharmaceutical andhealth sector

Securing public financing Mobilization of other financial

resources


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The Policy Can be Implemented in

Containing pharmaceutical Price and Cost

A national policy for the use of generics

Reduction or elimination of import

duties for pharmaceutical Price competition

Price information


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Mesure to Monitor and Improve the

Overall Supply

Product selection

Drug quantification

Drug procurement Drug storage and distribution


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The Principles of Rational Drug Use

Appropriate clinical indication and not the otherreason

Appropriate drugs with the most favourableefficacy, safety, affordability and quality

Appropriate patient characteristic with no contraindication and the smallest likehood of adversereaction

Appropriate dosage, route of administration andduration

Appropriate information Appropriate follow up for intended effect and

unintended side effect.


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The Pattern of Irrational Drug Use

The use of wrong drug for specificcondition

The use of drug

There are not indication

Doubtful efficacy and uncertain safety status

Incorrect dosage, inadequate route ofadministration

With multiple therapy when mono-therapycould already be sufficient

Too expencive


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REFERENCIES

Santoso B. Drugs Regulation :Organization and Control. In Boxtel C. J.V. Santoso B. And Edwards I. R. DrugBenefits and Risk : International

Textbook of Clincal Pharmacology. NewYork : John Wiley & Sons Ltd. 2001 :61-70

Santoso B., Suryawati S., Saleh-Danu S.Masalah Penggunaan Obat di Institusi

Pelayanan Kesehatan dalam FarmakologiKlinik dan Farmakoterapi. BagianFarmakologi Klinik FK UGM. 2003 : 1-9


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THANKS.

LETS SMILE WITH SCIENCE

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K11 - PHARMCOSOCIAL-1