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Katie R. Hurley 13385 Hughes Court Office Phone: (612) 625-4236 Apple Valley, MN 55124 E-mail: steve795@umn.edu

EDUCATION University of Minnesota Twin Cities Mentor: Christy L. Haynes

Ph.D. in Chemistry (GPA: 3.87) summer 2015 (expected) M.S. in Chemistry (GPA: 3.87) 2012

Carthage College, Kenosha, WI B.A. in Chemistry (GPA: 3.93) 2010 EXPERIENCE University of Minnesota Department of Chemistry Graduate Research Assistant September 2010 - present

Designed and synthesized multifunctional mesoporous silica nanoparticles for in vivo imaging, drug delivery, and magnetic fluid hyperthermia applications with consideration for future scale up and good manufacturing process (GMP) synthesis conditions.

Characterized materials in biologically-relevant environments (salt and protein-containing media) with light and electron microscopy, colorimetric assays, ICP-OES of dissolved ions, benchtop relaxometry for magnetic properties, etc.

Determined the effects of aggregation on iron oxide nanoparticle function and effectively halted negative effects via the addition of a functionalized mesoporous silica shell

Collaborated with chemists, mechanical engineers, radiologists, and cancer biologists to investigate complex problems related to nanoparticle behavior in vivo

Utilized synthetic skills and electron microscopy expertise to assist collaborators with projects unrelated to thesis work (nanoparticle uptake studies, dark field microscopy method development, protein nanoring characterization)

Contributed to the design and content of two funded research grant proposals totaling $397,000

Disseminated research results with 12 peer-reviewed papers and various professional presentations

Filed a provisional patent on the synthesis of iron oxide and mesoporous silica nanoparticles

Maintained comprehensive paper and electronic documentation of experimental design, procedures, results, and analyses

Actively participated in weekly group meetings during which ecological nanotoxicity, analytical UPLC/MS/MS methods, and polymer synthesis/characterization methods were discussed

Research Mentor for Undergraduate Students June 2011 - present

Planned and directed research projects for three undergraduate students for at least one year each

Determined priorities and timelines appropriate for each student’s experience level, available time, and enthusiasm for the project

Developed critical thinking, experimental design, and time management skills in students through daily informal discussions and weekly research meetings

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Helped to secure presentation opportunities, monetary research support, and academic awards for each (including three research fellowships, two honors fellowships, two presentations, one travel grant, two academic manuscripts under review, and one internship at a device manufacturing company)

Organic and Analytical Chemistry Teaching Assistant September 2010 – May 2011

Supervised 14 undergraduate students of varying majors for eight hours per week during chemistry laboratory sections

Taught and enforced safety practices (100% of students indicated that the use of PPE was always enforced)

Developed critical thinking and reasoning skills in students (79% of students rated my ability to develop critical thought as ‘outstanding,’ and 93% would prefer to learn from me in a future class)

Prepared and delivered pre-lab lectures indicated by students to be clear, appropriate in length and content, and interesting

University of Minnesota Departments of Chemistry and Chemical Engineering Joint Safety Team Founding Member and Administrative Committee Chair 2012 - 2015

Together with Dow Chemical Company and student partners, initiated and developed a researcher-led organization to positively change the culture of safety in two academic departments encompassing >600 active researchers

Spearheaded initial organization efforts, defined goals in comprehensive “JST Recommendations”

Coordinated the efforts of >60 laboratory safety officers as various committees made posters, developed safety trainings, conducted informal audits, etc.

Saved >$4500 in unknown waste identification costs via the organization of department-wide cleanup days for chemicals and equipment

Educated other organizations (within the University of Minnesota and nationally) about how to start their own JST through instructional videos, demonstrations, and invited presentations

Northwestern University Department of Chemistry Research Experience for Undergraduates (REU) Researcher, mentored by Mercouri Kanatzidis 2009

Used high temperature solid state techniques to synthesize and characterize three new thermoelectric materials based on metal chalcogenides with a SnSe minor phase for improved heat to electricity energy conversion efficiency

University of Wisconsin Milwaukee Great Lakes WATER Institute Research Experience for Undergraduates (REU) Researcher, mentored by James T. Waples 2008

Tracked groundwater seepage into the Wisconsin coastline of Lake Michigan using naturally-occurring radium tracers

Modified and applied oceanographic techniques to a freshwater system

Carthage College, Kenosha WI Department of Chemistry Student Researcher, mentored by Christine Blaine 2008

Monitored seasonal changes in the salt concentration of the Pike River in Kenosha, WI, using a chloride ion-specific electrode and other analytical techniques

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PUBLICATIONS Hurley, K.R.; Ring, H.L.; Kang, H.; Klein, N.D.; Haynes, C.L. “Characterization of Magnetic Nanoparticles in Biological Matrices” invited feature article for Analytical Chemistry, Submitted Hang, M.; Gunsolus, I.; Wayland, H.; Melby, E.; Mensch, A.; Hurley, K.; Pederson, J.; Haynes, C.; Hamers, R. “The Impact of Nanoscale Lithium Nickel Manganese Cobalt Oxide NMC on Bacterium Shewanella oneidensis MR-1” In Revision Feng, Z.V.; Gunsolus, I.L.; Qiu, T.A.; Hurley, K.R.; Nyberg, L.H.; Frew, H.; Johnson, K.P.; Vartanian, A.M.; Jacob, L.M.; Lohse, S.E.; Torelli, M.D.; Hamers, R.J.; Murphy, C.J.; Haynes, C.L. “Impacts of Gold Nanoparticle Charge and Ligand Type on Surface Binding and Toxicity to Gram-Negative and Gram-Positive Bacteria” Submitted Hurley, K.R.; Ring, H.L.; Etheridge, M.L.; Zhang, J.; Klein, N.D.; Szlag, V.; Chung, C.; Shao, Qi.; Reineke, T.M.; Garwood, M.; Bischof, J.C.; Haynes, C.L. “Predictable Hyperthermia and Positive MRI Contrast from a Mesoporous Silica-Coated Iron Oxide Nanoparticle” Submitted Klein, N.D.; Hurley, K.R.* Feng, Z.V.; Haynes, C.L. “Dark Field Transmission Electron Microscopy as a Tool for Identifying Inorganic Nanoparticles in Biological Matrices” Analytical Chemistry 2015, 87, 4356-4362. *co-first author Egger, S.M.; Hurley, K.R.; Datt, A.; Swindlehurst, G.; Haynes, C.L. “Ultraporous Mesostructured Silica Nanoparticles” Chemistry of Materials 2015, 27, 3193-3196. Etheridge, M.L.; Hurley, K.R.; Zhang, J.; Jeon, S.; Ring, H.L.; Hogan, C.; Haynes, C.L.; Garwood, M.; Bischof, J.C. “Accounting for Biological Aggregation in Heating and Imaging of Magnetic Nanoparticles” Technology 2014, 2, 214 Kim, D.; Finkenstaedt-Quinn, S.; Hurley, K.R.; Buchman, J.T.; Haynes, C.L. “On-chip evaluation of platelet adhesion and aggregation upon exposure to mesoporous silica nanoparticles” Analyst 2014, 139(5), 906-913. McGarry, K.; Hurley, K.R.; Volp, K.; Hill, I.; Merritt, B.; Peterson, K.; Rudd, P.; Erickson, N.; Seiler, L.; Gupta, P. Tolman, W.; “Student Involvement in Improving the Culture of Safety in Academic Laboratories” J. Chem. Ed. 2013, 90(11), 1414-1417 Hurley, K.R.; Lin, Y.-S.; Zhang, J.; Egger, S.M.; Haynes, C.L. “Effects of Mesoporous Silica Coating and Post-Synthetic Treatment on the Transverse Relaxivity of Iron Oxide Nanoparticles” Chem. Mater. 2013, 25, 1968-1978. Lin, Y-S.; Hurley, K.R.*; Haynes, C.L. “Critical Considerations in the Biomedical Use of Mesoporous Silica Nanoparticles” J. Phys. Chem. Lett. 2012, 3, 364-374 *co-first author Lin, Y-S.; Abadeer, N.; Hurley, K.R.; Haynes, C.L. “Ultrastable, Redispersable, Small, and Highly Organo-Modified Mesoporous Silica Nanotherapeutics” J. Am. Chem. Soc. 2011, 133 (50), 20444-20457.

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Stevens, K.R.; Girard, S.N.; Johnsen, S.; Kanatzidis, M.G. “Investigation of the Thermoelectric Properties of Metal Chalcogenides with SnSe” Nanoscape 2010, 7, 52-58. PRESENTATIONS AND POSTERS “Functionalized Mesoporous Silica as a Versatile Protective Coating for Iron Oxide Nanoparticles” (poster, one of 8 finalists for best poster award) American Society of Mechanical Engineers 4th Global Conference on Nanoengineering for Medicine and Biology (ASME NEMB) 2015 Katie R. Hurley, Hattie L. Ring, Connie Chung, Michael Etheridge, Qi Shao, Jinjin Zhang, Qi Shao, Victoria Szlag, Theresa Reineke, Michael Garwood, John C. Bischof, and Christy L. Haynes “Utilizing Iron Oxide and Mesoporous Silica Nanoparticles for Biomedical Applications” (invited poster) University of Minnesota Doctoral Dissertation Showcase 2015 Katie R. Hurley, Hattie L. Ring, Connie Chung, Michael Etheridge, Jinjin Zhang, Qi Shao, Victoria Szlag, Theresa Reineke, Michael Garwood, John C. Bischof, and Christy L. Haynes “The Power of Rust and Sand at the Nanoscale: Iron Oxide and Mesoporous Silica Nanoparticles for Theranostic Applications” (presentation) American Chemical Society Spring Meeting 2015 Katie R. Hurley, Hattie L. Ring, Connie Chung, Michael Etheridge, Jinjin Zhang, Qi Shao, Victoria Szlag, Theresa Reineke, Michael Garwood, John C. Bischof, and Christy L. Haynes “The Power of Rust and Sand at the Nanoscale: Iron Oxide and Mesoporous Silica Nanoparticles for Biomedical Applications” (invited presentation) University of Minnesota Doctoral Dissertation Fellowship Seminar Series, 2015 Katie R. Hurley, Hattie L. Ring, Michael Etheridge, Jinjin Zhang, Michael Garwood, John C. Bischof, and Christy L. Haynes “Improving the Biomedical Performance of Iron Oxide Nanoparticles via a Mesoporous Silica Shell” (poster) 93rd Graduate Women in Science Annual Conference, 2014 Katie R. Hurley, Hattie L. Ring, Michael Etheridge, Jinjin Zhang, Michael Garwood, John C. Bischof, and Christy L. Haynes “Biological Use of Mesoporous Silica and Iron Oxide at the Nanoscale” (presentation) Graduate Women in Science – Xi Chapter Meeting, 2014 Katie R. Hurley, Hattie L. Ring, Michael Etheridge, Jinjin Zhang, Michael Garwood, John C. Bischof, and Christy L. Haynes “Improving the Biological Performance of Iron Oxide Nanoparticles via a Mesoporous Silica Shell” (poster) Society for Thermal Medicine Annual Meeting, 2014 Katie R. Hurley, Hattie L. Ring, Michael Etheridge, Jinjin Zhang, Michael Garwood, John C. Bischof, and Christy L. Haynes

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“Improving the Biological Performance of Iron Oxide Nanoparticles with a Mesoporous Silica Shell” (presentation) Materials Research Society Spring 2014 Meeting, 2014 Katie R. Hurley, Hattie L. Ring, Michael Etheridge, Jinjin Zhang, Michael Garwood, John C. Bischof, and Christy L. Haynes “Student Involvement in Improving the Culture of Safety in Academic Research Laboratories: A Case Study from the University of Minnesota” (invited presentation) Duquesne University, Pittsburg, Pennsylvania, 2014 Katie R. Hurley, Melissa Baudhuin, Katie Peterson, Theodore Knudson, Christopher Smith, Clifford Gee, Haley Phillips, and Alyssa McKenna

“Imaging, Drug Delivery, and Magnetic Fluid Hyperthermia with Iron Oxide and Mesoporous Silica” (presentation) University of Minnesota Women in Science and Engineering Luncheon, 2013 Katie R. Hurley, Yu-Shen Lin, Michael Etheridge, Sam Egger, Jinjin Zhang, John Bischof, and Christy L. Haynes “Understanding and Controlling Nanoparticle Aggregation for Improved Imaging and Therapy” (presentation) University of Minnesota 12th Chemistry Graduate Student Research Symposium, 2013 Katie R. Hurley, Yu-Shen Lin, Michael Etheridge, Jinjin Zhang, Sam Egger, John Bischof, and Christy L. Haynes “Theranostic Nanoparticles in the Haynes Lab: Iron Oxide and Mesoporous Silica as a Winning Combination” (poster) Institute for Engineering in Medicine Annual Conference and Retreat, 2013 Katie R. Hurley, Hattie Ring, Joseph T. Buchman, Michael Etheridge, Jinjin Zhang, Michael Garwood, John Bischof, and Christy Haynes “Transverse Relaxivity Investigations of Mesoporous Silica Nanoparticles” (presentation) Graduate Women in Science – Xi Chapter Meeting, 2013 Katie R. Hurley, Yu-Shen Lin, Jinjin Zhang, and Christy L. Haynes “Synthetic Considerations for Optimal Magnetic Resonance Imaging Contrast in Fe3O4@Mesoporous Silica Nanoparticles” (poster) 243rd American Chemical Society National Meeting and Exposition, 2012 Katie R. Hurley, Yu-Shen Lin, and Christy L. Haynes “Synthetic Considerations for Optimal MRI Contrast in Magnetic Mesoporous Silica Nanoparticles” (poster) 4th EuCheMS Chemistry Congress in Prague, Czech Republic, 2012 Katie R. Hurley, Yu-Shen Lin, Sam Egger, Jinjin Zhang, and Christy L. Haynes “Effects of Mesoporous Silica Coating on the Transverse Relaxivity of Iron Oxide Nanoparticles” (invited presentation) Cancer Nanotechnology Conference: Mechanisms in Nanoparticle Hyperthermia, 2012 Katie R. Hurley, Yu-Shen Lin, Jinjin Zhang, Sam Egger, and Christy L. Haynes

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AWARDS AND HONORS University of Minnesota Graduate School Doctoral Dissertation Fellowship 2014 National Science Foundation Graduate Research Fellowship 2011 - 2014 Xi Chapter of Graduate Women in Science Agnes Hansen Travel Award 2013 Mary Haga Travel Award 2012 University of Minnesota Twin Cities Department of Chemistry Beaker and Bunsen Award for Outstanding Oral Presentation 2013 American Chemical Society 4th EuCheMS Chemistry Congress Travel Award 2012 APPLICABLE SKILLS

Inorganic nanoparticle synthesis

Powder x-ray diffraction

Transmission electron microscopy o Cryogenic/room temperature o Soft and hard materials o Biological sample prep o Electron energy loss spectroscopy o Energy dispersive spectroscopy

Dark field light microscopy

Nitrogen physisorption

Dynamic light scattering

Zeta potential measurements

Benchtop relaxometry

Magnetic properties measurement systems

UV-visible spectroscopy

Ion selective electrodes

Laser flash analysis (LFA) for thermal conductivity measurements

Electrical conductivity and Seebeck Coefficient measurements

Atomic absorbance spectroscopy

Experimental design

Technical writing

Grant applications

Mentoring

Team leadership

Data analysis

Record-keeping

Communication to non-experts

Graphic design for scientific figures