Kevin Kauweloa Ph.D.

MEDICAL PHYSICSIST/CLINICAL ASSISTANT PROFESSOR DEPARTMENT OF RADIATION ONCOLOGY UNIVERSITY OF KANSAS MEDICAL CENTER 3901 RAINBOW BOULEVARD KKAUWELOA@KUMC.EDU WORK: (913) 588-8499

CELL: (808) 864-5496

EDUCATION

Residency Sep 2015 to Sep 2017 University of Texas MD Anderson Cancer Center, Houston, TX Therapeutic Medical Physics Department of Radiation Physics Director: Mohammad Salehpour, Ph.D.

Ph.D. Medical Physics Aug 2012 to May 2015 University of Texas Health Science Center San Antonio, San Antonio, TX Dissertation: Practical aspects and applications of the three-dimensional biological effective dose in multi-phase radiotherapy treatment plans

M.S. Medical Physics Aug 2009 to May 2012 San Diego State University, San Diego, CA Thesis: Dependence of imaging dose on free-breathing cone-beam computed tomography dynamic tumors

B.S. Physics & Math Aug 2003 to May 2008 Linfield College, McMinnville, OR Thesis: Filtering irrelevant events from rare isotope nuclei mass measurement data

EMPLOYMENT

Medical Physicist/Clinical Assistant Professor Sept 2017-Present Department of Radiation Oncology University of Kansas Medical Center, Kansas City, KS Physics/Math Tutor Aug 2011 to May 2012 Department of Athletics San Diego State University, San Diego, CA

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Physics Teaching Assistant Aug 2009 to May 2011 San Diego State University, San Diego, CA Math Teaching Assistant Aug 2006 to May 2008 Linfield College, McMinnville, OR Physics Teaching Assistant Aug 2005 to May 2008 Linfield College, McMinnville, OR

CERTIFICATION STATUS

2014 - American Board of Radiology (ABR) – Therapeutic Medical Physics (TMP), Passed Part 1. 2017 - ABR-TMP, Passed Part 2. Will be taking Part 3 in May 2018.

MEMBERSHIP

American Association of Physicists in Medicine (AAPM) National Mathematical Honorary Society, Pi Mu Epsilon

CLINICAL EXPERIENCE

Medical Physics Resident 2015 to Present University of Texas MD Anderson Cancer Center, Houston, TX The following list highlight things I have covered in my CAMPEP approved residency up to this point. Brachytherapy:

• Nucletron HDR Daily QA and source exchange • Oncentra HDR APBI and GYN Treatment Planning with Patient MRI & CT Scan • LDR Seed Assays, Eye-Plaque Treatment Planning - Brachyvision, and LDR Prostate Permanent

Implants • PDR Treatment Planning and Manual Implant with Tandem and Ovoids • Variseed Monthly QA and Treatment Planning

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• Patient survey following treatment

External Beam Radiation Therapy: • 3D-CRT, IMRT (Step-and-Shoot & VMAT), and SBRT Treatment Planning using Pinnacle • Daily, monthly, and annual machine QA on Varian (21ex, Triology, True Beam) and Elekta HD Versa • Acceptance and commissioning for Varian True Beam LINAC and Orthovoltage • Patient-specific IMRT QA for standard treatments and spinal stereotactic radiosurgery • MU Calculation and Verification • TG-51 Reference Dosimetry • In-vivo Dosimetry with TLDs and Diodes • External Annual OSLD and TLD Output Checks • IGRT with Cone Beam CT (XVI and OBI) • Motion Management with ExacTrac and Vision RT • Image Registration with Pinnacle and Velocity • Phillips Big Bore 4DCT simulator Monthly QA • TBI Compensator Design (Lung and Liver Blocks), MU Calculation, and Online Treatment • Machine Trouble Shooting (QA following machine fix) • MOSAIQ QAs (testing following update of patches) • Special Treatments: TSET, SRS, CSI, TBI • ISOCAL Test • Winston Lutz Test • Gamma Knife Treatments with Daily and Monthly QAs, and Patient Head Frame Measurements

Chart Checks: • Elekta MOSAIQ R&V System • Initial Chart Checks • Weekly Chart Checks • Final Close Outs

Radiation Safety: • Patient Discharge Survey • Radiation Survey for Orthovoltage Acceptance

Equipment:

• Sun Nuclear 1D & 3D Tank, Profiler2, IC Profiler • CATPHAN – used for monthly LINAC imaging QA • Solid and PMMA dosimetry phantoms • RADAC – measure shift of mechanical isocenter with rotation of gantry, collimator, and couch • RADCAL – secondary MU calculation software • Leeds Phantom • Farmer Ion Chamber • Archeck and Delta4 Phantoms

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• ExacTrac

The following are remaining rotations:

• Core – Pinnacle Commissioning, IMRT QA Commissioning • Imaging – MRI, CT, and Ultrasound and its applications in radiation therapy • Proton • Open – cover deficiencies/weaknesses

Clinical Projects:

• In Head and Neck Service: “Evaluation of the larynx motion using four-dimensional and breath-hold computed tomography”

• In Imaging rotation: “Evaluation of the significance of MR imaging distortion”

RESEARCH EXPERIENCE

Graduate Medical Physics Research Assistant Aug 2012 to May 2015 Cancer Therapy and Research Center, San Antonio, TX Department of Radiation Oncology Director and Advisor: Nikos Papanikolaou, Ph.D. Co-advisor: Panayiotis Mavroidis, Ph.D. PROJECTS:

• “Practical aspects and uncertainty analysis of biological effective dose (BED) regarding its three-dimensional calculation in multiphase radiotherapy treatment plans”

• “Clinical analysis of the approximate, three-dimensional, biological effective dose equation in multi-phase treatment plans”

• “Application of the biological effective dose (BED) to evaluate and optimize hypo fractionated stereotactic body radiotherapy fractionation schemes for multi-prescription liver cancer treatments”

• “A graphical user interface (GUI) toolkit for multi-phase biological effective dose (BED) calculations including statistical analyses”

• “Cumulative biological effective dose calculations of cervical cancer patients treated with high-dose rate brachytherapy and external beam radiotherapy”

COLLABORATIVE PROJECTS DURING PHD: • “TCP/NTCP comparison between planned and delivered treatments of head-and-neck cancer patients” –

Netherlands Cancer Institute (NKI), Netherlands and UTMD Anderson

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Graduate Medical Physics Research Assistant Jan 2010 to May 2012 University of California San Diego Moores Cancer Center, San Diego, CA Department of Radiation Oncology Director: Todd Pawlicki, Ph.D. Advisor: William Y. Song, Ph.D. PROJECTS:

• “Evaluation of GateCTTM tracking system for respiratory signal reconstruction in 4DCT imaging” • “Dependence of imaging dose on free-breathing cone-beam computed tomography of dynamic tumors”

Undergraduate Physics Research Assistant Jun 2007 to Aug 2007 Michigan State University, East Lansing, MI Research Experience for Undergraduates (REU) Advisor: Georg Bollen, Ph.D. PROJECT:

• “Filtering irrelevant events from rare isotope nuclei mass measurement data”

Undergraduate Physics Research Assistant Jun 2006 to Aug 2006 SRI International, Menlo Park, CA Research Experience for Undergraduates (REU) Molecular Physics Laboratory Advisor: Gregory Faris, Ph.D. PROJECT:

• “Tumor boundary detection using fluorescence”

EDITORIAL ACTIVITIES

• Reviewer: Medical Physics Journal 2015 to Present • Reviewer: Oncotarget 2015 to Present

HONORS • AWARDS

• 3RD PLACE AWARD for an oral presentation of the Young Investigator’s Symposium at the 2014 Annual Southwest AAPM meeting at San Antonio, TX.

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• THE PALMAZ RESEARCH AWARD at University of Texas Health Science Center San Antonio, Department of Radiology.

PROGRAMMING LANGUAGES

• Matlab, C, C++, Fortran.

MANUSCRIPTS SUBMITTED

1) Kauweloa KI, Gutierrez AN, Bergamo A, Stathakis S, Papanikolaou N, Mavroidis P, “Application of the biological effective dose (BED) to evaluate and optimize hypofractionated stereotactic body radiotherapy fractionation schemes for multi-prescription liver cancer treatments,” Physica Medica. – Addressing reviewer comments.

2) Kauweloa KI, Kirby N, Gutierrez AN, Eng T, Stathakis S, Papanikolaou N, Mavroidis P, “Cumulative biological effective dose calculations of cervical cancer patients treated with high-dose rate brachytherapy and external beam radiotherapy,” at Cancer Therapy and Research Center. Soon to be submitted to the Medical Physics Journal.

PEER REVIEWED PUBLICATIONS

1) Kauweloa KI, Ruan D, Park J, Sandhu A, Kim G, Pawlicki T, Watkins WT, Song B, Song WY, “GateCTTM tracking system for respiratory signal reconstruction in 4DCT imaging,” Med. Phys., 39, 492 (2012).

2) Park J, Park SH, Kim JH, Yoon SM, Song SY, Liu Z, Song BY, Kauweloa KI, Webster MF, Sandhu A, Mell LK, Jiang SB, Mundt AJ, Song WY, “Liver motion during cone-beam computed tomography guided stereotactic body radiation therapy,” Med. Phys., 39, 6431 (2012).

3) Kauweloa KI, Park JC, Sandhu A, Pawlicki T, Song B, Song WY, “Visibility of internal target volume of dynamic tumors in free-breathing cone-beam computed tomography for image guided radiation therapy,” Prog. Med. Phys., 24, 220-29 (2013).

4) Stathakis S, Mavroidis P, Shi C, Xu J, Kauweloa KI, Narayanasamy G, Papanikolaou N, “γ-index: a new evaluation parameter for quantitative quality assurance,” Computer Methods Programs Biomed., 114, 60-9 (2014).

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5) Kauweloa KI, Gutierrez AN, Bergamo A, Stathakis S, Papanikolaou N, Mavroidis P, “Practical aspects and uncertainty analysis of biological effective dose (BED) regarding its three-dimensional calculation in multi-phase radiotherapy treatment plans,” Med. Phys., 41, 071707 (2014).

6) Kauweloa KI, Gutierrez AN, Stathakis S, Papanikolaou N, Mavroidis P, “A graphical user interface (GUI) toolkit for multi-phase biological effective dose (BED) calculations including statistical analyses,” Computer Methods and Programs Biomed., 131, 1-12 (2016).

7) Kauweloa KI, Gutierrez AN, Stathakis S, Papanikolaou N, Mavroidis P, “Clinical analysis of the approximate, three-dimensional, biological effective dose equation in multi-phase treatment plans,” Medical Dosimetry. (2017).

ABSTRACT PUBLICATIONS

1) Haushalter JP, Amin K, Chao W, Kauweloa KI, Haroon Z, Faris G. “Enzyme-Based Labeling of Tumor Boundaries,” Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference and Photonic Applications Systems Technologies, OSA Technical Digest Series (CD) (Optical Society of America, 2007), paper CFC6.

2) Watkins WT, Kauweloa KI, Park J, Lewis J, Song WY. “Disparity between 4D-CT and CBCT reconstruction of internal target volume (ITV),” Med. Phys., 37, 3422 (2010). Conference: AAPM 52nd Annual Meeting, Philadelphia, PA, July 18-22, 2010.

3) Kauweloa KI, Song WY. “Evaluation of surface tracking system for respiratory sensing in 4DCT: Commissioning of GateCT,” Med. Phys., 38, 3468 (2011). Conference: AAPM 53rd Annual Meeting, Vancouver, Canada. Poster Presentation, July 31, 2011.

4) Kauweloa KI, Park J, Song WY. “Dependence of imaging dose on image quality of free-breathing 3DCBCT of moving tumors,” Med. Phys., 39, 3653 (2012). Conference: AAPM 54th Annual Meeting, Charlotte, North Carolina. Poster Presentation, July 29, 2012.

5) Kauweloa KI, Papanikolaou N, Stathakis S, Esquivel C, Crownover R, Mavroidis P. “Analysis of two overall biological effective dose (OBED) calculation methods and their impact on the accurate determination of the maximum biological effective dose (BED) in multi-phase treatment plans,” Med. Phys., 40, 370 (2013). Conference: AAPM 55th Annual Meeting, Indianapolis, Indiana. Poster Presentation, August 4, 2013.

6) Kauweloa KI, Gutierrez A, Bergamo A, Stathakis S, Papanikolaou N, Mavroidis P., “Mathematical analysis of approximate biological effective dose (BED) calculation for multi-phase radiotherapy treatment plans,” International Journal of Cancer Therapy and Oncology, 2, 2 (2014). Conference: Southwest AAPM Annual Meeting 2014, San Antonio, Texas, April 11, 2014. Oral Presentation - Young Investigator’s Symposium 3rd Place Award.

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7) Kauweloa KI, Gutierrez AN, Bergamo A, Stathakis S, Papanikolaou N, Mavroidis P, “Mathematical analysis of approximate biological effective dose (BED) calculation for multi-phase radiotherapy treatment plans,” Med Phys., 41, 344 (2014). Conference: AAPM 56th Annual Meeting, Austin, Texas. Poster Presentation, July 20, 2014.

8) Kauweloa KI, Gutierrez AN, Bergamo A, Stathakis S, Papanikolaou N, Mavroidis P, “Clinical analysis of the approximate multi-phase biological effective dose (BED) calculation,” Med Phys., 41, 339 (2014). Conference: AAPM 56th Annual Meeting, Austin, Texas. Poster Presentation, July 20, 2014.

9) Bergamo A, Kaweloa KI, Patel AJ, Mavroidis P, Papanikolaou N, Stathakis S, Gutierrez AN, “Hypofractionated liver stereotactic body radiation therapy: Biological Effective Dose correlated radiation-induced liver disease,” Int. J. Radiat. Oncol. Biol. Phys., 90, S849 (2014) Conference: ASTRO’s 56th Annual Meeting, San Francisco, CA, September 14-17, 2014.

10) Kauweloa KI, Gutierrez A, Stathakis S, Papanikolaou N, Mavroidis P, “A graphical user interface (GUI) toolkit created for multi-phase biological effective dose (BED) calculations including statistical analyses,” Med Phys, 42 3227 (2015). Conference: AAPM 57th Annual Meeting, Anaheim, California. Poster Presentation, July 12, 2015.

11) Bergamo A, Kauweloa KI, Daniels J, Crownover R, Mavroidis P, Papanikolaou N, Gutierrez A, “Dose-volume toxicity analysis of stereotactic body radiation therapy for hepatocellular carcinoma,” Med Phys., 42, 3238 (2015). Conference: AAPM 57th Annual Meeting, Anaheim, California. Poster Presentation, July 12, 2015.

12) Kauweloa KI, Bergamo A, Gutierrez A, Stathakis S, Mavroidis P, Papanikolaou N, Kirby N, “Uncertainties associated with dose summation of high-dose rate brachytherapy and intensity modulated radiotherapy for gynecological cases,” Med Phys., 42, 3291 (2015). Conference: AAPM 57th Annual Meeting, Anaheim, California. Poster Presentation, July 12, 2015.

13) Kim J, Park C, Kauweloa KI, Chung Y, Han Y, Ju S, “A novel digital tomosynthesis system using orthogonal scanning technique: a feasibility study,” Med Phys., 42, 3611 (2015). Conference: AAPM 57th Annual Meeting, Anaheim, California. Oral Presentation, July 12, 2015.

14) Bergamo A, Kauweloa KI, Ha CS, Mavroidis P, Papanikolaou N, Gutierrez AN, “Inverse planned conformality and normal tissue complication probability effects for high risk pelvic lymph node irradiation,” Int. J. Radiat. Oncol. Biol. Phys., 93 (3), E571-E572, (2015). Conference: ASTRO’s 57th Annual Meeting, San Antonio, TX, October 18-21, 2015. Poster Presentation

15) Kauweloa KI, Bergamo A, Gutierrez AN, Stathakis S, Papanikolaou N, Mavroidis P, “Use of the 3-D biological effective dose (BED) for optimizing liver cancer SBRT treatments,” Int. J. Radiat. Oncol. Biol. Phys., 93 (3), E580 (2015). Conference: ASTRO’s 57th Annual Meeting, San Antonio, TX, October 18-21, 2015. Poster Presentation.

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16) Heukelom J, Fuller CD, Kantor M, Kauweloa KI, Mavroidis P, Rasch CR, Sonke JJ, “NTCP differences between planned and delivered dose in treatment for head and neck cancer,” Radiotherapy and Oncology (Green Journal), (2016). Conference: ESTRO’s 35th Annual Meeting, Turin, Italy, April 29-May 3, 2016. Poster Presentation.

17) Kauweloa KI, Wang H, Garden A, Chi PC, Rosenthal D, Fuller C, Gunn G, Morrison W, and Phan J, “Evaluation of the larynx motion using four-dimensional and breath-hold computed tomography,” Int. J. Radiat. Oncol. Biol. Phys., (2017). Conference: ASTRO’s 59th Annual Meeting, San Diego, CA, September 24-27, 2017.