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L-Measure: a software tool for the analysis of neuronal morphology…
…and its application to hippocampal pyramidal cells.
L-MEASURE: MORPHOMETRIC ANALYSIS OF NEURONAL TREES
Why dendritic morphology?The study of dendritic morphology is a key to correlate neuronal structure, activity, and function.
Sridevi Polavaram*, Ruggero Scorcioni, Giorgio A. Ascoli: Krasnow Institute for Advanced Studies
Bifurcation angle …
Branch length
Real dendrite
http://www.krasnow.gmu.edu/ascoli/CNG/
George Mason University
L-MEASURE: MORPHOMETRIC ANALYSIS OF NEURONAL TREES
Sridevi Polavaram*, Ruggero Scorcioni, Giorgio A. Ascoli: Krasnow Institute for Advanced Studies
George Mason University
Total sum #compartments #discarded Min Avg Max SDVolume 3797 5571 302 0 0.687 372.7 7.14
http://www.krasnow.gmu.edu/ascoli/CNG/
Sample Output
Quantitative morphometry of reconstructed hippocampal pyramidal cells: Differences between anatomical subregions and reconstruction laboratories.
Ruggero Scorcioni1 ([email protected]), MT Lazarewicz2, GA Ascoli1
1:George Mason University 2: University of Pennsylvania
0.6
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5 10 15 20 25 30 35
Max Branch Order
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trac
tion
A1
T1
C1
A3
T3
C3
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30 40 50 60 70
Remote Bifurcation Angle
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le
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T1
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0 100 200 300Frequency (Hz) equal injection
Fre
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en
cy
(H
z) n
orm
aliz
ed
in
jec
tio
n
T3
A3
T1
A1
http://www.krasnow.gmu.edu/ascoli/CNG/
CA3 CA1CA3 CA1