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L-Measure: a software tool for the analysis of neuronal morphology… …and its application to

L-Measure: a software tool for the analysis of neuronal morphology… …and its application to hippocampal pyramidal cells

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Page 1: L-Measure: a software tool for the analysis of neuronal morphology… …and its application to hippocampal pyramidal cells

L-Measure: a software tool for the analysis of neuronal morphology…

…and its application to hippocampal pyramidal cells.

Page 2: L-Measure: a software tool for the analysis of neuronal morphology… …and its application to hippocampal pyramidal cells

L-MEASURE: MORPHOMETRIC ANALYSIS OF NEURONAL TREES

Why dendritic morphology?The study of dendritic morphology is a key to correlate neuronal structure, activity, and function.

Sridevi Polavaram*, Ruggero Scorcioni, Giorgio A. Ascoli: Krasnow Institute for Advanced Studies

Bifurcation angle …

Branch length

Real dendrite

http://www.krasnow.gmu.edu/ascoli/CNG/

George Mason University

Page 3: L-Measure: a software tool for the analysis of neuronal morphology… …and its application to hippocampal pyramidal cells

L-MEASURE: MORPHOMETRIC ANALYSIS OF NEURONAL TREES

Sridevi Polavaram*, Ruggero Scorcioni, Giorgio A. Ascoli: Krasnow Institute for Advanced Studies

George Mason University

Total sum #compartments #discarded Min Avg Max SDVolume 3797 5571 302 0 0.687 372.7 7.14

[email protected]

http://www.krasnow.gmu.edu/ascoli/CNG/

Sample Output

Page 4: L-Measure: a software tool for the analysis of neuronal morphology… …and its application to hippocampal pyramidal cells

Quantitative morphometry of reconstructed hippocampal pyramidal cells: Differences between anatomical subregions and reconstruction laboratories.

Ruggero Scorcioni1 ([email protected]), MT Lazarewicz2, GA Ascoli1

1:George Mason University 2: University of Pennsylvania

Page 5: L-Measure: a software tool for the analysis of neuronal morphology… …and its application to hippocampal pyramidal cells

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http://www.krasnow.gmu.edu/ascoli/CNG/

CA3 CA1CA3 CA1

[email protected]