Lecture 1

Analytical Chemistry CHE301

Synthetic Chemistry Analytical Chemistry

To make a new stuff To find out what is it

“white powder”

Qualitative Quantitative

to identifyThis white powder is NaCl

to detectThere is a trace admixtureof iodine in this sample

to analyzeto determine X in a sample to quantifyto measure

Run assay determinationquantitation

0.375 mg/mL caffeine

Composition, %%:Cu, 85.34(3); Zn, 11.23; Sn, 1.02(2);Fe, 0.123(2); Mn, 0.058(5); Ni, 0.229(5); …

Analytical chemistry sequence @ BSC

CHE111-112Titrations with NaOH, EDTA, KMnO4, K2Cr2O7, , I2

Some separations and photometry

CHE203-204 Identification of organic compounds; IR, NMR, GC

CHE301 Analytical Chemistry itself: gravimetry, titrations,electrochemistry and spectrophotometry

CHE403 Instruments, how they work and how to operate them

Biochemistry, Advanced Analytical Chemistry, Analytical Toxilcology, and Inorganic Chemistry

- More about analytical methods

Definition of the problem

Chice of technique

Sampling

Sample pre-treatment

Quantitative analysis

Reporting the results

Review of the original problem

Analytical problems and procedures

Preliminary qualitative tests

A chocolate story: how much caffeine?

An example from Harris:

Garbage in,Garbage out!

Calibration