AI ..:.LEKETNAP. .

THANG 11 ..SO 22020

A A A

TONG HQI Y HOC VI~T NAMVIETNAM MEDICAL ASSOCIATION

68A Ba Tri~u - Hoan Kie'm - Ha NQi;Tel: 024-39431866Email: tapchiyhocvietnam@gmail.com; Webslte: tonghoiyhoc.vn

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MUCLUC• •T~p CHi Y HQC VII;T NAM T~P 496 - THANG 11 - so 2 - 2020

VIETNAM MEDICAL JOURNAL N02- NOVEMBER - 2020.. anh gia vai tro nQisoi 6 bunq trong chan doan va dieu tr] vet thu'dng tanq rangEvaluation the role of laparoscopic in diagnostic and treatment of holow viscusperforation wounds

Nguy~n Hoang Linh, Huynh Kim Khang, Ng_uy~nDuc Vd,Duong Van Hai, Nguyen Cong Minh

Phl:lc hoi thanh cong rang ora sua sau va Ion bang chup Zirconia co sanTreatment anterior crown with pre-fabricated Zirconia

Nguy~n Anh DU'O'ng,Vo Truong NhU'Ngoc, Ngo Van ToanThl/c tranq hoat dQngtiem phong benh dai t9i tinh Gia Lai, giai dean 2015 - 2019Situation of rabies vaccination in Gia Lai province, 2015-2019

Nguy~n Van Chuyen, Nguy~n Van Khai, Nguy~n Th] Minh NgocB~c diem lam sang va ket qua dieu tr! nQisoi cam rnau mOibang dong di~nl:linical characteristicsand endoscopicelectrocauterytreatment outcomesof epistaxis

Ha Phuong Thao, Trin Thi Mai5. Nghien cuu bao che vien nen Fexofenadinhydroclorid phan tan nhanh de tang hi~u

qua dieu tr] vlem mOid! ungPreparation and evaluation of Fexofenadinehydrochloride rapid dispersible tablets toincreasethe effectiveness for treatment of allergic rhinitis

Vii Van Tu~n, Nguy~n Van B~chNghien cuu cai thien dQon d!nh thudc tlern Rotundin sulfat de tang tac dl,mgan thanStudy on improving stability of Rotundine sulfate injection to increasesedative effect

Nguy~n Thi Ha, Nguy~n Van B~chKet qua bu'ocdau nQisoi 0 bl:lngdieu tr! vet thu'dng cd hoanhThe initial result of laparoscopictreatment diaphragm wounds

Nguy~n Hoang Linh, Huynh Kim Khang,Nguy~n Du-cVii, DU'ongVan Hai, Nguy~n Cong Minh

Nghien cuu d~c diem lam sang va c~n lam sang cua b~nh nhan viem gan B m9n tfnhdu'Q'cdi'eutr! bang thuac Tenofovirl:linical characteristics of chronic hepatitis B cured by Tenofovir

Da Thi Quynh, Vii Van Nga, Bid Thi Thu HoaiBanh gia rai lo~n chuyen hoa cald - phospho - PTHa b~nh nhan 19Cmau chu ky t9iKhoath~n Tiet ni~u - L9Cmau, B~nhvi~n Huu NghiEvaluating the metabolism trouble in dialysis patients at neuphrourology - dialysisdepartment, Huu Nghi Hopital .

Trinh Thi Thanh H~ng, Nguy~n Van Tin, Nguy~n Th~ Anh10. Khao sat sl/ tuan thu dieu tri Tenofovir tren b~nh nhan viem gan B m~n tfnh

Investigation of Tenofovir treatment adherence in chronJchepatitis B patientsVii Van Nga, Do Thj Quynh, Vii Thj ThO'm,

Le Thj Di~mHAng,Bui Thj Thu Hoai11. O'ng dl:lng ky thu~t multiplex PCRphat hi~n cac gen mcr-1, mcr-2 va mcr-5 khang

colistin a cac chung Escherichiacoli phan I~p tu cac trang tr9i ga a Ha NamApplication of the multiplex PCRtechnology for detection of colistin resistant mcr-1,mcr-2 and mcr-5 genes in the Escherichiacoli strains isolated from the chicken farmsin Ha Nam

Hoang Thi }\1aiHU'O'ng,Hoang Thj An Ha, Vii Nhi Ha,Hoang Thj L~an, Phung The Khang, Ph~m Duy Thai, Trin Huy Hoang

12. Banh qia tlnh tranq nhiem virus viem qan B, C a b~nh nhan 19Cmau chu ky t9i khoaTh~n tiet ni~u-19Cmau, B~nhvi~n Huu NghiInfection with hepatitis Band C virus in dinalysis patients at the nephrology-dialysisdepartment, Huu Nqhi Hospital ,

Nguy~n Van Tin, Trinh Thi Thanh Han!!. Hoan!! Manh Tron!!.• • x X I..Nguyen Le Hoa, Nguyen The Anh

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13. Thl/c tranq kern khoanq hoa men rang ham Ion - rang ctra 0 nhorn h9Csinh 12-15 51tuoi t~i tinh BinhDlnh narn 2019-2020The current situation of molar incisor hypomineralistaton in group of 12-15 years oldstudents in Binh Dinh province in 2019-2020

_ Nguy~n Phuc Minh, Vo Truong NhU'NgQc14. Mqt sod~cdiem dkh te hoc cac ca tu vong do benh dai tai tinh Sdn La (2015 - 2019) 55

Someepidemiologicalcharacteristicsof human rabiesin SonLaprovince(2015- 2019)Nguy~n Van Chuyen, Nguy~n Van Ba, Hoang Th] Thuan

15. Thay dOi tham my m~t nha voi ph§u thuat phoi hop dich chuyen tien ham va tao 59hlnh camSimulataneuos premaxilla osteotomy and genioplasty on the facial profileattractiveness of patients with convex face

DB Tuin Ngoc, But Huu Phurrc,ve Hang Lie~, Hoang Tuin Anh

16. So sanh ke'tqua dieu tr] dom nau anh sang cua Laser nano giay Q-Switched Nd: YAG 63532 nm va Laserpico giay nd: YAG532 nmQ-Switched double frequency Nd:YAG 532-nm nanosecond Laser vs. doublefrequency Nd:YAG532-nm picosecondlaser for the treatment of solar lentigines

Pham Thj Mai Trinh, Le Hfru Doanh, ve Thai Ha17. B~c diem di can h~ch bach huvet vung co trong ung thu bieu ma tuyen giap bi~t hoa 68

Characteristics of cervical lymph node metastasisin differentiated thyroid cancerNguy~n Van Nam, TrAn Xuan BQVii Anh Hai, Le Thi Tuy~t Nhung

18. Mqt so d~c diem lam sang va c~n lam sang cua rang ham seraham tren co b~nh 1'1 71tuy ho~i tU 0 mqt nhom b~nh nhan den kham t~i B~nh vi~n Rang Ham M~t TrungL(dng Ha Nqi nam 2019Clinical and radiographic evaluation of primary upper molars with necrotic pulp ofyoung patients at Hanoi National Hospital of odonto-stomatology

Le NgQcDi~p, VOTruong Nhu NgQc,Ph~m Hoang Tuin, Nguy~n Thi Van Anh

19. Mqt so d~c diem dich t~ h9Cvi khuan Rickettsia0 Mien sac Vi~t Nam 75Epidemiological characteristics of Rickettsia in North Vietnam

LuO'ngThi HAngNhung, Nguy~n Vii Trung,Le Thi HQi,Ma Thi Huyin

20. Thl/c tr~ng tai n~n thL(dng tfch cua tre nh~p khoa cap cuu t~i B~nh vi~n Nhi Trung 79L(dngtU' 7/2019 - 6/2020Situation of children's injury admitted the emergency department at viet namNationalChildren's Hospital from 7/2019 - 6/2020

Nguy~n Thi Huyin Sam, Truong Thi Mai HAng21. Banh gia ket qua ph§u thu~t dieu tri h~p dqng m~ch canh ngoai S9t~i B~nhvi~n Da 82

khoaDong NaiResults of extracranial carotid artery endarterectomy in Dong Nai ProvinceHospital

Tr~n Quy~t Ti~n, Nguy~n Anh Diing22. Hi~u qua rna hinh phl:1Choi chuc nang dl/a vao cQngdong cho ngL(Oikhuyet t~t v~n 86

dQngt~i huy~nThong Nhat tinh Dong NaiThe effectiveness of community-based rehabilitation for people with mobilitydisabilities in thong nhat district Dong Nai Province

Nguy~n HAngQuang, Nguy~n Xuan Bai, Ph~m Van TrQng23. Ket qua ph§u thu~t nQisoi cat rUQtthLtaqua dL(ongam d~o 90

The results of laparoscopicappendectomy through vaginal routeDB Tit Thanh, Tr~n Binh Giang

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24. Kha nang cung ung dich vu cham soc tre so sinh tal Trung tam Y te huyen Kim Boi, 93tinh Hoa Binh, narn 2019Infant care service delivery providing at Kim Boi District health center in Hoa BinhProvince in 2019

Nguy~n QuAcTi~n, Nguy~n Quang T,!, Nguy~n Dang Vtmg,Pham Hai Thanh, Nguy~n Huu Thing

25. Cck yeu to dlj bao ket cue d benh nhan dQt quy thleu rnau nao cec bQ cap tfnh du'<;>'c 97dieu tr] tai tu'oi mau bang lay huyet khoi cd hoc ket hop d~t stent cap ciru thuoc tuanhoan nao truceOutcome forecast factors in patient with acute ischemic stroke received reperfusintreatment using mechanical thromboembolism combined with anterior cerebralcirculation emergency stent

Nguy~n Van Huy, Mai Duy Ton, Le HAngTrungDito Vi~t Phuong, Vii Dang LU'U,Tdn Anh Tu~n

26. Tinh hinh tang ap luc 0 bunq va mQt yeu to nguy co 0 benh nhan n~ng nh~p vi~n 102khoa Hoi sire Tfch cueIntra-abdominal hypertension and some risk factors in patients who admitted to theintensive care unit

D~ng Th] Huong, Dao Xuan CO'27. Hoi tu'dng quan giG'a ap luc nQi SQva diem glassgow d b~nh nhan xuat huyet nao 5 105

ngay dauCorrelation between the intrcranial pressure and glassgow score in patients withbrain hemorrhage for the first 5 days

Le Thi Bich Thiiy, ~guy~n Van ChU'O'llg28. KhilO sat cac yeu to lien quan den muc dQn~ng cua b~nh gan nhiem ma khong do ru'<;>'u 109

Related factors of severe nonalcoholic fatty liver diseaseVo Duy Thong, D6 Duc Minh

29. Tinh tr~mg trCing qua huyet ap Iu'u dQng d b~nh nhan IQcth~n 113Dipper pattern on ambulatory blood pressure monitoring in the hemolysis patients

Chau Huu HAu,Nguy~n Minh Tri30. KhilO sat ta du'Q'cdong kho cho cong thl)'C bao che thuoc tiem dong kho liposome 117

amphotericin BInvestigation lyophilized excipients for the preparation formulation of liposomalamphotericin B for lyophilized injection

Nguy~n Tu~n Quang, Ph~m Thi Minh Hu~, Nguy~n Thai SO'll31. HQt so yeu to lien quan toi thai gian dieu trl cua ngu'ai b~nh viem loet giac mi;lc 120

Factors related to treatment duration in patients with corneal ulcerD~ng Thi Hai Hit, Ph~m HAngVan

32. Banh gia hi~u qua kiem soat ho hap cua phu'dng phap thong khf ap Iljc du'dng ngat 123quang dau trung tam ket h<;>'pngoi;li vi trong ph§u thu~t ti;lo hinh khf quanEvaluate the effectiveness of airway management using distal tracheal intubationand intermittent positive pressure ventilation for tracheal resection andreconstruction surgery

Dinh Thi Thu Trang, Nguy~n Minh Ly,Cong Quy~t Thing, TAngXuan Hung

33. Thljc tri;lng dam bao thuoc thong qua hinh thuc dau thau ti;li B~nh vi~n Quan Y 105 128tlt nam 2015 - 2018Current situation of drug security through drug bidding at 105thmilitary hospital from2015 to 2018

HACanhH~u, Nguy~n Minh Chinh,Hoang Hai, Nguy~n CAmVan, Vii NgQcMai

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34. Nghien cuu d~c diem lal}l sang due the thuv tinh sau chan thu'dng va mQt so yeu totien hrono thi nrc sau ohau thuat dieu triClinical characteristicsand prognostic factors for visual outcome of traumatic cataract

Pham Phuong Dung, Th§m Truong Khanh Van35. 8anh gia ket qua phuc hoi chuc nang nh~n tmrc cho benh nhan chan thu'dng S9 nao

tal B~nhvi~n Phuchoi Chuc nang Ha NQinarn 2019 - 2020Functional cognitive assessmentof the patient after traumatic brain injury

Phan Thi Ki~u Loan, Ph~m Van Minh36. Banh gia hi~u qua phuc hoi chirc nang thang bang tren ngu'oi benh nhoi rnau nao t1;li

B~nhvi~n Lao khoa Trung u'dngAssessment the effectiveness of balance rehabilitation for patients after cerebralinfarction at National Geriatric Hospital aa Thi HUiYDgMinh, Cao Minh Chau

37. B~c diem lam sang va c~n lam sang cua benh nhan tnrot dot song don tang dokhuyet eoClinical and subclinical of patients with one-level lumbar spondylolisthesis

. Tdn HBng Vinh, Nguy~n Van Thach, Vii Van Hoe38. Khao sat chi so FIB-4 trong dl,(doan gian tinh mach thirc quan d b~nh nhan xd gan

co chu'angInvestigation apri indicator to predict esophageal varices in cirrhosis patients withascites

ve Duy Thong, HAThi Van Anh39. Thl/c tranq ngu'oi khuyet t~t v~n dQngva phuc hoi chirc nang cho ngu'oi khuyet t~t

v~n dQngdl/a vao cQngdong tc;lihuy~nThong Nhat tinh Dong NaiThe current situation and community-based rehabilitation for people with mobilitydisabilities in Thong Nhat district Dong Nai Province

Nguy~n HAng Quang, Nguy~n Xuan Bai, Ph~m Van TrQng40. Danh gia chat1u'Q'ngkhOitieu (au trong quatrlnh baoquanva moi lien quan giO'acu'ong

dQhuynhquangvai doi songcua tieu caudu'Q'csanxua'tbang phu'dngphap buffy coatAssessment the quality of platelets during storage period and the collerationbetween the fluorescence intesity and the lifetime of platelets produced by buffy coatmethod

Nguy~n Thj Lan, Luu Thj Thu Phuong,Tr§n Van Tinh,. Nguyin Dac Thao, Tr§n Thj Thanh Tam

41. Nhu cau cham soc dai hc;lncua ngu'oi cao tuoi d mQtso xa thuQc huy~n SocSdn, HaNQinam 2018 - 2019.tong-term careneedof elders in somewards in SocSondistrict, HaNoi in 2018 - 2019

Nguyin Thi Thu Huy~n, Ph~m Le Tuin42. Phau thu~t ung thu'tuyen giapd ngu'Oib~nhBasedowtc;IiB~nhvi~n NQitiet Trung u'dng

Thyroid cancer surgery in patients with Basedowdiseaseat the National Hospital ofendocrinology " ' ,Ph~m Quyet Thang, Tran NgQc LuongDa Thanh Cong, Truong Quang Huy

43. Banh gia cau truc vi the va dQben cua ma van tim lQ'nsau bao quan Ic;lnhsauEvaluation of the microstructure and tensile strength of the cryopreserved porcineheart valve

Cu Thj Bich Thuy, Ngo Duy Thin, Duong Cong Nguyen,Le Thj HAng Nhung, M§u Van Cal!h

44. Kinh nghi~m bu'acdau sU'dl,lng du'ong lIlo it xam Ian qua md ngl/c phai trong ph§uthu~t thay van hai 113tc;liB~nhvi~n ChQ'RayEarly experience of minimal invasive surgery by the right thoracotomy in mitralvalve replacement at the cardiac surgery deparment of Cho RayHospital .

Lam Tri~u Phat, TrAn Quy~t Ti~n

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45. U'ng dunq thuc nqhlern phau thuat n9i soi qua duang am dao tren lon giai doan 1732011- 2014Applying experimental laparoscopicappendectomythrou~h vaginal route on pig

D6 Tat Thanh, Trin Blnh Giang46. Kha nang cung lIng dich vu cham soc SlICkhoe so sinh tal cac Tram Y te xa, huy~n

Kim BOi,tinh Hoa Blnh, nam 2019Ability to provide neonatal medical health care services at commune healthcarestations at Kim Boi Provine, Hoa Binh District, 2019

Nguy~n Qu6c Ti~n, Nguy~n Quang Tu,Nguy~n Dang Vu'ng, Pham Hai Thanh, Nguy~n Hfru Thi~g

47. Banh gia ket qua phau thuat cat amidan bang dao LigasureThe evaluation results of tonsillectomy method with Ligasure

Nguy~n Phuong Thao, Nguy~n Quang Trung48. Nghil~nClIUsir thay doi the tfch the chai tren hinh anh c9n9 hu'ang tir a benh nhan

nghi~n ruouResearch on change in volumes of corpus callosum on magnetic resonance imagingof the alcoholic patient

Le Phi Dlili,Nguyen Thi Sinh, Tran Ngoc Anh, D~ng Ti~n Truong49. B~c diem lam sang, chan doan hinh anh b~nh Iy do d!ch nao tuy do vo nen S9sau

chan thu'dng S9nao t~i B~nhvi~n Vi~t £)lIC«;Iinical characteristics and imaging evaluation of cerebrospinal liquid leak (csf)causedby skull base fracture post traumatic injury in Viet Duc Hospital .

_ Ngo Manh Hung, TrAn Blnh Ngoc, Nguyjn Duc Dong50. Banh gia tinh tranq nhiem khuan b~nh vi~n a b~nh nhan du'qc dieu tr! ECMOt~i

B~nhvi~n B~chMaiEvaluate hospital associated infections in patients who were on ECMOat Bach MaiHospital

Trin Duc Trung, Dao Xuan CO'5!. C.c3cyeu to anh huang ket qua dieu tr! viem loet d~ day ta trang helicobacter pylori

du'dng tfnh bang phac do 3 thuoc Amoxicilin, Levofloxancin, PPI t~i B~nhvi~n TrungU:dnaThai NauvenClinical factors influencing the efficacy of H.pylori eradication of triple therpy(Amoxicilin, Levofloxancin, PPI) in Thai NguyenGeneralHospital

Ngo Duc hQ'P,Duong HAng Thai, Nguy~n Thj Thu Huy~n52. Tinh hinh nhi~m nam Malasseziatren benh nhan viem da cd dia tai Benh vien Da

Ii~uTrung u'dng . . .. .Malassezla infection in patient with atopic dermatitis at National Hospitaldermatology and venerology

Nguy~n Van Hi~u, Trin CAm Van, Phlilm 'fhi Minh Phuong53. Banh gia ket quahoax~ tri dongthai tjen phauungthu'bieurnathl/c quan 1/3 giO'adu'Oi

Assessment of the rusults of preoperative chemoradiotherapy for esophagealcancerPhlilm Quang Anh, VOVan Xuan

54. Banh gia d9Ctfnh ban tru'ang di ~n tren h~ t~o huyet cua vien nang ClIng Fucolensau bao che tren d9n9 v~t thl/c nghi~mExamines the semi-chronic toxicities of Fucolenon experimental animals

Trin Thanh Huong, TrAn Van Thuin, Vii Mlilnh TuAn,Nguy@nVan Khiem, Dao Van Tu, Nguy~n Ti~n Quang

55. Nh~n xet ket qua sau 2 tuan dieu tr! Esomeprazoletrongviem diil day khang kerntheo loet a tre nhi~m HelicobacterPylori tiili B~nhvi~n Nhi Trung u'dngAssesment of treatment result with esomeprazole after 2 weeks for non- ulcergastritiScombined HelicobacterPylori infection in vietnam national Hospital'SChildr~n

DilOThj Ngoan, Phan Thj Hien

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56. B~c diem lam sang c~n lam sang va thai gian song them khang benh ung thir bieu 214ma tuyen che nhay de day giai doan II, IIIClinical characteristics and complementary examination, disease free survival andsome factor affect diseasesurvival of muciousgastric cancer stage II-III

Nguy~n Thi H~ng, Trinh Le Huy, Le Van Thimh57. B~c diem lam sang va m9t so yeu to lien quan den b~nh vlem da dau tal B~nhvi~n 218

Da Ii~uTrung u'dngClinical manifestations and several factors relating to seborrheic dermatitis inNational Hospital of Dermatology and Venereology

Truong Th] Thanh Huong, Nguy~n Huu Sau, Trin cim Van58. B~c diem lam sang va nhu cau cham soc dieu du'ong trong ngay dau cua ngu'ai benh 221

c6 h9i chung cai nrouClinical characteristics and needs for care in the first day of of patients with alcoholwithdrawal syndrome

DB Thi Hoa, Nguy~n Doan Phuong, Le Thi Thu Ha,Nguy~n Th] Hila, Pham Xuan Thing

59. Ket qua sam ph§u thuat teo ruot non bam sinh tal B~nhvi~n HO'unqhl Vi~t Duc giai 225doan 2017 - 2019Results of surgical treatment for jejunoileal atresia in infant at Viet Duc UniversityHospital from 2017 to 2019

Chu Minh Phuc, Nguy~n Vi~t Hoa, Vii Hang Tuan60. Bi~u qua dieu tri cua colchcin trong may day man tfnh til phat

Colchicine in the treatment vietnamese patient with chronic spontaneous urticariaNgo Th] Minh Nguy~t, Pham Thj Lan

61. Banh gia ket qua dieu tr] Erlotinib bu'acm9t tren benh nhan ung thu' phoi khang tebim nho giai dOe;!niv c6 d9t bien EGFRAssessment treatment outcome of first-line Erlotinib in patients with advanced EGFRmutation-positive non-small-cell lung cancer

Nghiem TrAn VU'Q'Ilg,Nguy~n Ti~n Quang, Le Thi Y~n62. Trai nghi~m cua giang vien ve chu'dngtrlnh giao dl,lcdieu du'ong dy'a vao nang h!c

Perceived experiences of nurse educators in a competency - ba.sed nursingcurriculum: a qualitative descriptive study

Nguy~n Thi HAngAnh, Ph~m Thi Thuy Dung63. Thl/c tre;!ngtiem chung day du va dung lich cua tre em du'ai 1 tuoi t9i huy~n Tr9m

Tau, tinh Yen Bai nam 2019The fully and scheduled immunized situation among under 1-year-old children inTram Tau district, Yen Bai province in 2019

Cao Bach, LQCThi Mai, Le Thi Thanh Xuan64. Ket qua dieu tri soi ni~uquan 1/3 du'aibangTamsulosinti;li B~nhvi~nDe;!ihQcY HaN9i

Results of therapy of therapy of under 1/3 by Tamsulosin treatment in HospitalUniversity of Hanoi

Trinh Anh Tu§n, Vii Nguy~n Khai Ca65. Gia tri cua tY I~ dau ra nang noan (FORT)vai ket qua kfch thfch buang trung

Use of follicular output rate (FORT)to predict ovarian stimulation outcomePh,m Thi Anh, Nguy~n Lien PhU'ong,

LU'UQuynh HU'ong,HASy Hung66. Khao sat cautruc vi the thanh tinh machtinh cua nhO'nqbenh nhanqian tinh mi;lchtinh

Evaluating the microstructure of veinous walls in patients with varicoceleNguy~n Hoai Bic, Dinh Van Toan,Ph,m ThuAn M,nh, Hoang Long

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67. Hi~u qua khU'te bao mang nqoel tim bo bang SodiumDodecySulfate 256Decellularized effect and extracellular structure of bovine pericardium after treatmentwith Sodium DodecySulfate

Nguy~n Van Hoang, Ngo Duy Thin,i.e Thi HAngNhung, Miu Van Canh

68. "~c diem lam sang, nQisoi va mo benh hoc 0 benh nhan dieu tr] cat tach nlem mac 259dai true trangClinical, endoscopic and histopathological features in patients undergoing endoscopicsubmucosaldissection

Le Phu Tai, Nguy~n Cdng Long69. Khao sat tinh tri;!ngnhiemkhuantiet ni~u0 benh nhantrong 3 thangaau saughepth~n 263

Investigationof the urinary tract infections in kidney transplant recipents in the first3 months after transplantation in bach mai hospital

Hoang Thi Nhan, Mai Thi Hiin, Nguy~n Thi Hmrng70. Hi~u qua cua phu'dng thirc AVAPS0 benh nhan d<;1tcap b~nh phoi tac nghen man 266

tlnh (COPD)du'<;1Cthong kh( nhan tao khong xam nh~pEffectiveness of AVAPS in acute exacerbation of chronic pulmonary obstructivediseasepatients on non invasive mechanicalventilation

Vii Trung Kien, B&NgQcSan71. Cd cau benh tai mOihQng0 ngu'oi lao dQngcua t~p doan Viettel qua kharn srrc khoe 270

dlnh ki nam 2019 - 2020Structure of ear, nose and throat diseaseamong employees of Viettel group throughperiodic health examination in 2019 - 2020

Nguy~n L,p SO'n,Pham Huy Tin72. Nghien cru d~c diem lam sang, c~n lam sang 0 benh nhan tang triglyceride mau cao

Study on clinical and subclinical characteristics in patients with high degree ofhypertriglyceridemia

Nguy~n Vi~t Hung, Nguy~n Khoa Di~u Van73. ~hi)Q sat d~c diem tinh dich do cua nam gioi c6 chuc nang sinh san binh thu'ong

Evaluation of semen parameters in fertile menNguy~n Hoai B~c Nguy~n Cao Th~ng, Hoang Long

74. Gia trl cua thang diem hacor de dl,(doan ket qua cua tho may khong xam nh~p trenb~nh nhan suy ho hap capThe value of the hacor scale in predicting result of non-invasive mechanicalventilation in patients with acute respiratory failure.

Phan Thi Lan HUO'ng,BBNgQcSO'n,Phung Nam Lam75. Banh gia ket qua dieu trl ph§u thu~t ung thu' phan con Ii;!idi;!day

Efficacy of surgical management of gastric stump cancerPhan Hfru Huynh, Ha Hili Nam

Trin Blnh Tan, Ph~m Vii Minh Hoang76. B~c diem lam sang va hinh anh hQC0 b~nh nhan nhoi mau nao h~ song - nen

Clinical and imaging features of vertebrobasilar ischemicstroke patientsNguy~n Thi Tuyit Trinh, Nguy~n Van HUOng,Le Tu§n Linh

77. Ket qua ph~u thu~t cattoan bQdi;! day do ung thu' 0 b~nh nhan cao tuoi t<;liB~nhvi~n K Trung u'dngThe results oftoltal gastrectomy in olderly patients with gastric cancer in NationalCancerHospital

Nguy~n Van Tung, Ph~m Van Binh, Vii Thi Hang Anh

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78. Khaa sat dQ dai co tU' cung 0 1000 thai phu c6 tuoi thai tir 20-24 tuan bang sieu am 298qua du'ang am daoEvaluatian of the cervical length at 20-24 week' gestatian in 1000 pregnancies bytransvaginal ultrasound

H~ Van Quy, Vii Ba Quy~t, Nguy~n Xuan Hq'i,_ Dao Thi Hoa, Phan Thi Thu Nga

79. Ket qua dieu tr] naa LIng thuy bam sinh bang phau thuat nQi sot pha san naa that III 302ket hop dot dam roi mach macOutcames of treatment cangenital hydracephalus by endoscopic thirdventriculastamy withcharoid plexus cauterizatian

. Dao Th] Mo, Cao Vii Hung, 1)8Thanh Huong80. Banh gia ket qua dieu tr] ung thu' phoi khong te baa nh6 giai doan III tren ngu'ai caa 305

tuoi bang h6a X<;I tri dong thaiAssess the treatment results af concurrent chemaradiatian in elder patients withstage III nan - small cell lung cancer at K Hospital

Ph~m Van Phat, ve Van Xuan81. B~c diem rOi loan cu'dng du'dng va mQt s6 yeu to lien quan 0 benh nhan benh th~n 310

man giai doan IV tal khoa Than - Tlet nieu B~nh vi~n Bach MaiCharacteristics af erectile dysfunctian and same related factars in patients with stage IVchranic kidney disease at the department af nephran - urolagy af Bach Mai Haspital

D8 Cong Huan, Nguy~n Quang82. Nghien diu dQc tfnh va anh hu'ong cua la ng6n va hi;lt cay C9Craa len mQt so chi tieu 313

h6a sinh tren dQng v~t thl/c nghi~mStudying an taxi city and efectiveness af the gelsemium elegans and jatropha curcasseed extract an biachemistry af animal madel

Hoang Anh Tuin, Hoang Gia Bao83. U'ng dl:lng thang diem radnan cai tien trang danh gia ton thu'dng da 0 b~nh xd cung 318

bi h~ thongUsing the madified radnan skin scare to. assess skin lesians in patients with systemicsclerasis

Hoang Vi~t Tai, Bui Hai Binh84. Tong ket cac baa caa lien quan den phan v~ trong cd so dCi'li~u baa caa W nguy~n 323

Vi~t Nam giai da~n 2010-2019Anaphylactic reactians in spantaneaus reparting database af vietnam from 2010 to. 2019

Truong Thi M§n, Nguy~n Phuong Thuy, Nguy~n Hoang Anh,D~ng Bieh Vi~t, Cao Thi Thu Huy~n, Nguy~n Hoang Anh,

Vii Dinh Hoa, Nguy~n Van Dinh85. B~c diem ngu'oi b~nh suy tim mi;ln, tinh tri;lng 10.au va ket qua cham soc ngu'oi b~nh 328

ti;li khaa tim mi;lch lao. h9C - b~nh vi~n tim mi;lch an giang nam 2020Characteristics af chronic heart failure and results take care patien at department timmach lao.hac - an giang cardiovascular haspital

Nguy~n Cong Thanh86. Thl/c tr<;lngtuan thu quy trinh do de thu'ong cua hQ sinh t~i khaa san B~nh vi~n San 333

- Nhi Tra Vinh nam 2020The current situattian af camplying with narmal delivery pracedures af midwives atthe department af abstetrics in Tra Vinh Obstetrics and Pediatrics Haspital, 2020

Huynh Thi Tuy~t Minh, Truong Quang Ti~n, T~ Van TrAm87. Banh gia anh hu'ong tren huyet dQng cua phu'dng phap gay te tuy song - ngaai 337

mang cung phoi hc;1pde mo lay thai tren sim phl,l c6 nguy cd caa tl,lt huyet apHemadynamic effect af cambined spinal epidural anesthesia far cesarean delivery inpatients with risk af hypatensian

Nguy~n Thi Thu Ba, Nguy~n Due Lam, Nguy~n Duy Anh

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TAP CHi Y HOC VIET NAM TAp 496 - THANG 11 - 56 2 - 2020

f>i;lihoc Y Ha NQi,Ha NQi,2. K.M. Matsuda et al., 2019, Skin thickness score

as a surrogate marker of organ involvements insystemic sclerosis: a retrospective observationalstudy, Arthritis research& therapy, 21, 1, 129-129

3. 1. Varga, 2014, Overview of the clinicalmanifestations of systemic sclerosis (scleroderma)in adults, UpToDate. Waltham, MA. RetrievedAugust, 4, 2014

4. V. Leroy et al., 2019, Association of skinhyperpigmentation disorders with digital ulcers insystemic sclerosis: Analysis of a cohort of 239patients, J Am Acad Dermatol, 80, 2,478-484

5. S. Amjadi et al., 2009, Course of the modifiedRodnan skin thickness score in systemic sclerosis

clinical trials: analysis of three large multicenter,double-blind, randomized controlled trials, Arthritisand rheumatism, 60, 8, 2490-2498

6. T. L. Moore, M. Lunt, B. McManus, M. E.Anderson, and A. L. Herrick, 2003, Seventeen­point dermal ultrasound scoring system-a reliablemeasureof skin thickness in patients with systemicsclerosis,Rheumatolo~y (Oxford), 42, 12, 1559-63

7. L. P. Lan, 2015, f>ac diem lam sang, can lams,~ngv~ c~u'cDang t~on~ kh.iyh~i (1 benh nhan xocl1ngbl h~ thong, LUi;lnan tien Sly hoc, f>ai hoc YHaNQi, . . .

8. N. S. Goh et al., 2008, Interstitial lung diseaseinsystemic sclerosis: a simple staging system, Am JRespirCrit Care Med, 177, 11, 1248-54

,.." "., , , ,,.. ,..,? A'

TONG KET CAC BAO CAO LIEN QUAN DEN PHAN VE TRONG CO'sa,nCr LIEU BAo cAo TU' NGUYEN VIET NAM GIAI DOAN 2010-2019. ... .

Truong Th] Mint, Nguy~n Phuong Thuy\ Nguy~n Hoang Anh2,D~ng Bieh Vi~t2,Cao Thj Thu Huy~n2,Nguy~n Hoang Anh',

, Vii Dlnh Hoa2, Nguy~n Van Dinh3

T6MTAT.Nghien oru du'gc tien hanh nham tong ket thong

tin ve cac phan ung phan v~ du'gc ghi nh~n tlt cac baocao tlj nguy~n trong cd so dO'Ii~u canh giac du'dc t~iVi~t Nam tlt nam 2010 den 2019. Cac bao cao tv'nguy~n du'gc sang IQ.cdu cac thong tin yeu cau choqua trinh danh gia phim ung theo tieu chuan dinhtru'ck. f>~cdiem cua hOi;ltdQngbao cao, d~c diem cuathuoc nghi ngo va phim ung phim v~ du'gc ghi nh~ncling voi t~o.ng tin ve xu tri ti;li ddn vi dieu tri du'gctong ket va mo ta. Ket qua cho thay phan v~ chiem13,7% so bao cao tv' nguy~n ADRti;li Vi~t Nam. f>dnvibao cao chu yeu thuQc khoi cong I~p (94,5%). Du'qc59 la doi tu'gng bao cao phan v~ nhieu nhat (41,4%).Co 81,8% bao cao ghi nh~n thong tin khai thac tien sU'di ung trong do co 1,6% b~nh nhan co tien sU'di ((ngvoi thuoc nghi ngo va 2,0% b~nh nhan co tien su diU'ngthuoc cling nhom vOi thuoc nghi n90. Khang sinhcephalosporinva carbapenem (51,5% tong so bao caophan v~), khang sinh penicilin (9,5%), thuDc canquang (5,3°~o),N~,!\IDst5,oo/~}la .~hO'n~nhom}h~§cdu'gc bao cao nhlE:~unhat. Cac tn~u chl1ng pho biennhat cua phan v~ la tren tuan hoan ~75,2%},ho hap(74,6%), da/niem mi;lc (55,6%). Co 38,4% tru'onghgp co bieu hi~n hi;l huyet ap nghiem trQng, 67,9%tru'ong hqp du'gc can bQy te danh gia la nghiem trQngva co 1,6% tru'ong hgp t(t vong. Corticoid (72,7%) vaadrenalin (68,2%) la 2 thuDCdu'gc su dl,mg pho bien

) Tfllt7ng Cao Dang DI.I(fc 7WHai Dl.ldng2Trung tam DI&ADR QG, Trl.lt7ngD~i h9C DI.I(fcHa N9i3Mnh v$nQuifc te'Vinmec TimesCity, D9i t'9C VinUniversityChiu trach nhi~m chinh: Tru'dng Thi ManEmail: vudinhhoa@gmail.comNgay nh~n bai: 24.9.2020Ngayphan bi~n khoa hQc:30.10.2020Ngayduy~t bai: 11.11.2020

nhat de xU'tri phan v~. Ket qua nghien ciru cung capthong tin can thiet cho hoat dQng theo doi va xU' triphan v~ ti;li cac don vi dieu tri cung nhu' gqi y cho cacgiai phap can thi~p cua cac cac cd quan quan Iy doivoi bien cO'y khoa nghiem trQng nay.

Til' khoa: phan ung phan v~, bao cao ADR, ti Iebao cao, xII tri phan v~, adrenalin. .

SUMMARYANAPHYLACTIC REACTIONS IN

SPONTANEOUS REPORTING DATABASE OFVIETNAM FROM 2010 TO 2019

The current study analyses information ofanaphylatic reactions (AR) based on spontaneousreports to National Pharmacovigilance Center from2010 to 2019. Individual Case Safety Report (ICSR)were screened for essential information and the ARwas assessed followed a prespecified criteria. Thecharacteristic of reporting activity, suspectedmedications and reported reactions were summarizedand described. The reported AR were in 13,7% ofspontaneous ICSR in Vietnam. The public sector hadmajor contribution, accounting for 94.5%. Pharmacistswere most active reporters contributing to 41,4% ofICSR.The history of allergy was reported in 81,8% ofcases. Of those, allergic to suspected medications orallergiC to medications which might cross reactivitywith the suspected one were 1,6%· and 2,0%respectively. The leading suspected medications werecephalosporins and carbapenems (51,5%), penicilin(9,5%), contrast media agents (5,3%) and NSAIDs(5,O%). The manifestations of RA occurred mainly incardiovascular, repiratory and subcutaneous systemswith prevalence of 75,2%, 74,6% and 55,6%,respectively}. Severe hypotension was reported in38,4% of cases. Servere reactions have beenidentified by reporters in 67,9% of reports, and thefatality rate was of 1,6%. Adrenalin and corticoid were

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VIETNAM MEDICAL JOURNAL N°2 • NOVEMBER· 2020

used to manage AR in 72,7% and 68,2% of patients,respectively), This study provides information for themanagement of anaphylatic reactions in healthcarecenters and suggestsfor the intervention of authority,

Keywords: Anaphylactic reaction, ADR report,reportingproportion,anaphylaxismanagement,adrenalin

v '" '"'I. £>AT VAN £>EPhiln v~ la mQt phan ((ng di ((ng toan than,

cap tinh xily ra sau khi tiep xuc voi di nguyen.Day du'qccoi la mQttrong nhG'ngphan ((ng nguyhiem nhat tren lam sang do thai gian khoi phatnhanh, c6 the gay t(( vong va khong the dl/ doandu'qc. Trong cac nguon dG' Ii~u ve philn v~, baocilO tl/ nguy~n ve philn ((ng co hc;licua thuoc(ADR) du'qc coi la n~uon thong tin quan trQnggiup danh gia d~c diem cGngnhu' sl/ hinh thanhtin hi~u philn v~. Ti;!i Vi~t Nam, theo nghien c((ucua LeThi Thuy Linh, so Iu'qng bao cao philn v~giai dOc;ln2010-2014 ta 2.161 ca, chiem 10,55%tong so bao cao ADR [2]. Trong giai dOc;ln2010-2016, Nguyen Khac DGngva cQng sl/ ghi nh~n55 bao cao philn v~ gU1ve Trung tam DI&ADRQUocgia la 4.873 ca, chiem 13,2% tong so baocao ADR [4], trong do co 111 ca t(( vong (chiem82% so Iu'qngca t(( vong trong 7 nam cua toanbQcd so dG'Ii~u ADR), trong khi do b~o cao lienquan den philn v~ chi chiem 0,9% tong so baocao trong cd so dG' li~u bao cao ADR toan caucua To ch((c Y te the gioi (Vigilyze) [5], Xuatphat tu thl/c te tren, nghien c((u du'qc thl/c hi~nnham tong ket d~c diem bao cao lien quan denphiln ve trong cd so dG' li~u bao cao tl/ nguy~nVi~t Na'mgiai dOc;ln2010-2019 de h~ tr$1congtac bao cao, x(( tri, dl/ phang va giilm thieu nguyco cua philn v~.

11.001TlIQNG VAPHlfO'NG PHAp NGHIENc(J'u1. D61tu'dng nghien cuu. Tat cil cac bao

cao tl/ nguy~j, ve philn ((ng co hc;licua thuoc(bao cao ADR) do can bQy te tren phc;lmvi cilnu'oc gU1ve Trung tam DI&ADR QUoc gia giaidoan 2010-2019.

'Du'a vao tieu chuan chan doan cac tru'onghdp 'philn v~ du'qc quy dinh trong Thong tu'si/2017/TT-BYT [1], cac bao cao philn v~ du'qcdu'a vao nghien c((u neu thea man 1 trong 2dieu ki~n sau:

- £)u'qc can bQy te me til la soc philn v~ ho~cphilO((ng philn v~

- ADRxuat hi~n trong yang 1 ngay tinh,tu Iandung thu5c cu5i cung va co it nhat mQt bieu hi~ntren 2 trong 4 h~ cd quan da/niem mc;lc-hohap­tieu hoa-tim mc;lchho~c co bieu hi~n hi;!huyet apnghiem trQng.

324

Tieuchuanloai tnn Cac bao cao ADRthieuthong tin ve thucc 'nghi ngo va bieu hi~n ADR.

2. Phu'dng phap nghh1!ncuu. Mo ta thongqua hoi cuu cac tru'ong hop phan v~ du'qc baocao ve Trung tam DI&,ADRQuoc gia trong giaidoan 2010-2019 voi cac chi tieu: So IWng, tY I~bao cao phan v~ trong cd so dG'Ii~u theo nam:thong tin hanh chinh ghi nhan tu bao cao phanv~; D~c diem b~nh nhan ghi nhan tu bao caophan v~; D~C diem cua thucc nghi ngo gay phanv~; D~c diem cua phan v~, cach xU' tri va ketqua sau xU'tri

Nhom thuoc c~a cac hOc;ltchat nghi ngo gayphan v~ du'qc phan 10c;lidl/a tren cd so phan 10c;lirna ATC).Thai gian tiem tang xuat hi~n philn v~,bieu hi~n cua philn1~tren cac h~ cd quan (phan10i;!itheo Hu'ong dan WHO - ADR Terminology2012) [6], m((c dQ nghiem trQng cua cac tru'onghdp philn v~ phan 10c;litheo Brown [3] va Hu'ongd§n QUocgia ve Cilnh giac Du'qc.

3. xU' Iy dU' Ii~u.Toan bQ dG' Ii~u du'qcnh~p, xU' 1'1'tren phan mem Microsoft OfficeExcel 2016 va SPSS22.0. Cac bien du'qc thongke theo tan suat va tY I~ phan tram.

III. KETQuA NGHIEN CU'UTu 73447 bao cao tl/ nguy~n Iu'utrG'ti;!i trung

tam 01 & ADR Quoc gia giai dOc;ln2010-2019,sau khi 10i;li1971 bao cao, co 10027 bao caophiln v~ da du'qc du'a vao nghien c((u.

Sc) Iu'qng,tV I~ bao cao phim v~ thf!o nam2500 20

18,,po 2000 16>c 14-III

12 'i"E. 15000 10 .....-III :!!'uo 1000 8

?:-III.0 6~ 500

0 02010 2011 2012 2013 2014 2015 2016 2017 2018 2019

....... 56 bao ,ao ph"n v~ _ TV I~ vOl t6ng so baDcao nghlen c(I'U(%)

Hinh1:So'lutlng va tY I~ baocaophan v~theo tung nam

So Iu'qng bao cao philO v~ tang aan qua cacnam tlt 155 bao cao (nam 2010) len 2235 baocao nam 2019 (hinh 1). T'1 I~ bao cao philn v~tren tong 55 bao cao ADR cua tung nam daodQng trong khoilng 9,1%-17,3% quanh gia tritrung binh la 13,7%

D~c diem cua ho~t dQng bao cao. Ddn vibao cao chu yeu thuQc khoi cong I~p (94,5%)

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TAP CHi Y HOC VIET NAM TAp 496 - THANG 11 - s6 2 - 2020

trong do benh vi~n tuyen tinh/thanh pho la donv] tham gia bao cao nhleu nhat (chiem 44,8%),khoi benh vlen tu' nhan chi chiem 5,5%. Ducc s9va bac s9 la 2 doi W<;1ngbao cao phan v~ nhieunhat, fan 1u'<;1tchlern 41,4% va 32,9%, dieudu'ong (19,2%),cac doi tu'<;1ngkhac (3,0%).

Bang 1:S~c diem thong tin hanh chinhA • , , • Aghi nhan tv bao caophan ve

TYI~Thong tin himh ehinh ghi Solu'qng (%)nh~n tit bao efto phim v~~cphim v~ (n =

10027'Oan vi bao e,ao

Benh vien tuyen'Trung u'dng 1228 122B~nh vi~n tuyen tinh/thanh 4493 44,8phoBenh vien tuyen quan/huyen 3317 33,1

Benh vien tu' nhan 552 55Be'nhvien nganh 241 2,4

Tru'ong f)ai hoc Y Du'dc 196 2,0001 tu'ang bao eao

Bac Sy 3301 329Du'dc Sy 4153 414

f)ieu dtiong 1923 19,2Khac 296 3,0

Khong co thong tin 354 35Thai gian bao eao

< 1 tuan 2631 26,21 tuan - 1 thanq 3688 36,8

> 1 thang 3640 36,3

Khong co thong tin I 68 I 0,7 ICac bao cao phan v~ duoc glri den Trunq tam

trong vonq 1 tuan chiem 26,2%, tu 1 tuan - 1thanq (36,8%), tren 1 thang (36,3%). Co 0,7%bao cao khong xac dinh du'<;1ckhoimg thai gianbao cao. Tronq 8205 bao cao (chlern 81,8% tongso bao cao phan v~) co ghi nh~n thong tin vevi~c khai thac tien SlI d! lIng, co 162 benh nhan(1,6%) co tien SlI d! lIng vOi chfnh thuoc nghingo gay phim v~, 202 b~nh nhan (2,0%) co tienSlI d! lIng vOi thuoc cling nhom voi thuoc nghingo gay phim v~.

f)~e diem ella thuoe nghi ngo gay phanv~. Phim v~ du'<;1cghi nh~n vOi hau het cac nhomthuoc, trong do nhG'ng nhom thuoc du'<;1Cbaecao nhieu nhat bao gem: nhom thuoc khangkhuan tac dl:mg tean than (J) chiem 76,7%,nhom thuoc tac dl:mg tren h~ than kinh (N)chiem 8,82%, mau va cd quan t<;le mau (B)chiem 6,6%, h~ cd -xu'dng (M) chiem 6,28%,thuoc can quang chiem 5,3% (bang 3). NhG'nghQ du'<;1cIy hay g~p trong cac bao cae phan v~bao gem: khang khuan' nhom cephalosporin vacarbapenem (chiem 51,5%), khang khuan nhompenicilin (chiem 9,5%), thuoc can quang (chiem5,3%), NSAIDs (chiem 5,0%). Trong 566 thuOcnghi ngo khac nhau da du'<;1cghi nh~n trong cacbao cae phan v~ co 10 thuoc nghi ngo co tansuat gay phan v~ cao nhat du'<;1ctrinh bay trongBang 2.

Bang 2. Sac diem thuoc nghi ngtYgay phan veNh6m thuoe - ma ATe Sobao eao Ty Ie 0/0

phan ve (n=10027)Khang khuan tac dung toan than (J) 7687 76,7

1 J01D - khang khuan beta-Iactam khac 5166 5152 J01C- khang khuan nhom beta-Iactam he penicilin 949 953 J01M- khang khuan nhom quinolon, khang khuan khac 1572 157

He than kinh (N) 884 881 N02-thuoc giam dau 338 3,42 N01-thuoc gay me va gay te 401 4,03 cae loai thuoc khac 145 1,5

Mau va cd quan tao mau (B) 665 661 B05-chat thay the mau va dich truyen 435 4,32 B02-thuoc cam mau, cae thuoc khac 230 23

He cd-xu'dnq (M) 630 6,31 M01A-NSAIDs 503 502 M03-thuoc qian cd 'M04-thuoc chonq qout 127 1,3

V08-thuoc can quanq 534 5,3Cac nhom thuoc khac 1073 107Mltai hoat chat nghi ngo gay phan ve nhieu nhat

1 Cefotaxim 1668 16,62 Ceftriaxon 955 9'5

3 Ceftazidim 720 7,2. ,.

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VIETNAM MEDICAL JOURNAL N°2 • NOVEMBER· 2020

4 Diclofenac 289 2,95 Cefuroxim 254 2,56 Iobitrldol 251 2,'57 Ciprofloxacin 247 2;58 Cefoperazon 241 2',49 Paracetamol 216 2210 Cefoperazon/sulbactam 213 2,1

f)u'ong dung cua cac thuoe nghi ngo gay phan ve1 Tinh mach 7850 78,32 Uong 1794 17,93 Tiem bap 1011 10,14 Du'ong dung khac 686 6,84- , , A .- N , A , , - ,Nhung du'ong dung pho bien nhat trong cac bao cao phan ve la du'ong tmh mach (78,3%), du'ong

uong (17,9%), du'ong tiem bap (10,1%). Cacdu'ong dung khac (bao gam: gay te, tiem du'oi da, d~th~u mon, khf dung, ng~m du'oi Iu'Oi,du'ong dQngmach, born vim tlt cung, thuy cham, nho mat, nhomUi) chiem 6,84%.

f)ije diem ella phim v~ ghi nh~n trong bao cao. Da so cat baocaophanv~ co thai gian tiemtang du'oi 10 phut (49,2%), 32,5% phan ltng xay ra trong yang tU' 10 phut den 1 giOva chi co 7,7%cac tru'ong hcp xay ra sau 1 gia. Co 10,6% bao cao khong ghi r6 thai gian tiem tang xuat hi~n phan v~.

B' 3 8v tltA' • h' A h' hA b"ang . ac tem cuap, an vegj I n an trong aocao.SoBC phan Ty I~ (0/0)

NQidung (n=v~ 10027)Bieu hien eua phan ve

H~tim m~eh: h~ huyet ap, m~ch nhanh, nhip tim nhanh, lo~n nhip, m~d 7542 75.2cham khonQbat du'dc, dai tieu tien khong tu' chu, nQat

H~ho hap: suy ho hap, kho tho, co that phe quan, tho khe, tho rft, thanh 7481 74.6Quansu'ng, phu du'onQho hap

Da/niem mac: ban do, me day, phu mach, nglta da, do va nglta mat 5576 55.6He tieu h6a: dau thu'dng vi, tieu chay, non lien tuc, dau bl,lngdG'd6i 2729 27.2Bieu hi~n khae: v~t va, va rna hoi, suy da t~ng, ret run, sot cao, hoa 2966 29.6

mat, chong mat, gong cltng ngu'aiMlte do nghiem trong ella phim ve phan loai theo Brown [3]

Nghiem trong mlte do 1 5376 53.6Ha huyet ap nghiem trQng 3851 38.4Bieu hien thieu oxYmau 1701 17.0Bieu hien tren he TKTW 1367 13.6

Nghiem trong mlte do 2 4632 46,2Khong xae dinh du'de 19 0l_2

Mlte do nghiem trong e(la phim ve phan loai theo bieu mau bao eaoADRTuvong 156 1,6

De doa tfnh mang 5069 50,6Nhap vien/keo dai thoi Qiannam vien 1697 16,9

ran tat vinh vien/nanQ ne 43 0,4Khong nghiem trong 2021 20,2

Khong r6 13 0,1Kh6ng co thong tin 1028 10,3. A , .A .A .'" '" A A , ,. A '"Phanv~ thu'ong du'c;1cbleu hl~n pho bien nhat tren h~ tim m~ch (75,2%) va h~ ho hap (74,6%) .

Tri~u ch((ng tren da ho~c niem m~c du'c;1cghi nh~n tren 55,6% so bao cao, tren tieu hoa (27,2%),cacbieu hi~n khac (29,6%). Cac bao cao co bieu hi~n nghiem trQng mltc 1 chiem 53,6% voi tl,lt huyet apnghiem trQng 113bieu hi~n pho biet nhat, chiem 38,4%. Bieu hi~n thieu oxy va thieu mau chiem ran1u'c;1t17,0% va 13,6%. Da so phan v~ du'c;1ccan bQy te danh gia la nghiem trQng, chi co 20,2% phanv~ du'c;1Ccoi 113kh6ng nghiem trQng.

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TAP CHi Y HOC VIET NAM TAp 496· THANG 11·562·2020

Bang 4. Dac diem vexu triphan veghi nhan trona bao ceo

each xU'tri Sa Be Ty I~ (%) Kit qua sau xU'tri Sa Be jry I~ (0/0

phi," v~ (n= tOO27) phan v~ (n=tOO27)

Corticoid 7294 72,7 TU'vong 163 f,6Adrenalin 6834 68,2 Chua hoi phuc 253 2',5

Lieu phap oxy 4710 47,0 Dang hoi phuc 3203 31;9Khanghistamin Hl va H2 4658 46,4 Hoi phuc co di chunq 92 0,9

Truven dich 4159 41;5 Hoi phuc khong co di chung 5383 53,7Thuoc khac 790 7,9 Khong ra 200 2,0

Kich thich beta 2 400 4;0 Khono co thong tin 733 7,3Van mach khac 366 3,7, , , A .~ ~ A , , A ~ .~

C~rtlcoldva,adrenal,1nI~ du'Q'c~u dunq p~o bien nhe~de xu tnAphan,v~, la~ 1u'Q'tchlern 72,7% va68!! Vo. ,K:t 9ua s~u ~utn ch? thay ca~ tru'ong hop hOIphuc khong co di chung va dang hoi phucchiem tV I~ Ion nhat, Ian 1u'Q'tla 53,7% va 31,9%. Co 163ca ghi nhan tu vong ung vai 1,6%. .IV. BANLU~N . cac tru'ong hop nhi~m khuan n~ng. Ngu'Q'clC;lithi

NghienCtIUda cho thay so 1u'Q'ngbao cao lien penicilin la mQt thuoc da du'Q'ccanh bao nhieu vequan den phsn v~ ghi nh~n du'Q'ctang theo thai c~c tru'ong hQ'pphsn v~ do do ft du'Q'ccan be?ygian trong 10 nam khso sat. Khang sinh trong do te h/a chQnsu dl,Jngtrong dieu trionhom cephalosporin va carbapenem du'Q'cghi Nhom thu5c co so bao cao phsn v~ CqO'thunh~n la cac thuOc pho bien nhat lien quan den hai trong cd so dCi' Ii~u la thu5c csn quangphsn ung phsn v~. Bh~uhi~n cua phsn v~ da (5,3%)" trong do dung dau la iobitridol (2,5%).dC;lngva xuat hi~n chu yeu tren h~ ho hap va tim Theo ca:: nghien nay, iopromid la thuoc csnmC;lch.Phan Ian cac phsn ung 0 muc de?nghiem qu~ng lien quan den nhieu tru'ong hQ'pphsn v~trQng va du'Q'CxU' trf bang adrenalin cung nhat, trong khi nghien cuu cua ch(mg toicorticoid. Da co 1,6% so bao cao ghi nhan benh iopromid chi dung thu 2 vai 1,1%. Su' khac bietnhan tU'vong. . . nat co the den tlt vi~c iobitridol du'~c sU'dl,m'g

So 1u'Q'ngbao cao phsn v~ tang dan theo tltng nhieu hdn i<?promid.Nghien cuu cua ch(mg toinam, tY I~ bao cao phsn v~ cung co xu hu'ang cho thay, bieu hi~n tren tuan hoan la thu'ong g~ptang va dao de?ngquanh gia tri trung binh nhat (75,2%) sau do den bieu hi~n tren ho hap13,7%. TV l~ nay cao hdn tY I~10,5% trong (74,6%), da/niem mC;lc (55,6%), tieu hoanghien cuu cua LeThi Thuy Linh giai dOC;ln2010- (27,2~0).:.MQt nghien cuu hoi cuu thl/c hi~n tC;li2015 [2]. So sanh vai cd so dCi'lieu bao cao tu' An DQcung cho ket qus vai ket cau tu'dng tu'vainguy~nVigilyze cua To chuc Y te the giai (2010~ bieu hi~n tren tuan hoan chiem 98,15%; ho2019) thi tY I~ nay la 0,9%[5]. Ket qus nay mQt h~p(81,48%), da (72,2%), tieu hoa (9,26%) [7].m~t cho thay nh~n th((c cua can bQ y te trong Ty I~ ~ay cao hdn trong nghien cuu cua chung toivi~c phat hi~n va bao cao nhCi'ngphsn ung nay co the do can be? y te thu'ong mo ts ngan gQntai Trung tam 01 & ADR Quac Gia da du'dc cai phan v~ chu khong mo til chi tiet cac bieu hienthi~n, m~t khac phsn anh thoi quen sU"dung tren tat ca cac h~ cd quan. .thuoc tren lam sang cua can bo y teo . Nghien cU'Ucung ghi nh~n 53,6% phim v~

Cephalosporin va carbapenem (chu yeu la xay ra muc de?nghiem trQng va co 1,6% tru'ongkhang ~nh cephalosporin) c~ tY I~ gay phsn v~ h9P t~ vo~g I~en9uan denAphan,v~. sy k~ac bi~tcao nhat (51,52%) - cao gap hdn 5 Ian nhom nay co the den tIf hOC;ltdQng canh bao tlch cl/cpenicillin (9,5%) trong nghien cuu cua chung toi. trong h~ thong y te tru'ac do ve h~u qua dangKet qua nay khac vai me?tsO'nghien cuu 0 Chau ti~c cua phan v~ neu khong du'Q'cxU'trf kip thaiAu da du'Q'ccong b5 tru'ac do khi ma khang sinh cung nhu' vi~c tang cu'ong cong tac quan IV,penicillin luon du'Q'cghi nh~n la thu5c co tY Ie giam sat phan v~ trong cac cd so y te nen cacgay phan v~ cao nhat nhu'ng tu'dng tl/ vai mot can be?y te da V thU'c hdn trong vi~c dl/ phongnghien cuu hoi cuu 0 Trung Quac vai 34,50/0 va xU' trf phan v~. Phan v~ Iii phan ung co thecephalosporin va 7,9% penicillins. Nguyen nhan phong tranh du'Q'cneu tim hieu ky tien sU'di ungco the do xu hu'angva thoi quen sU'dl:mg khang c~a b~nh nhan nhu'ng tren thl/c te, can bo y tesinh cua can bo y te 0 Viet Nam khi nhom van chu'a chu trQng den dieu nay do do v§n cocephalosporin dJQ'cdung ph6 bien hdn dOi vai mQt tY I~nho b~nh nhan g~p phsn v~ vai thuoc

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VIETNAM MEDICAL JOURNAL N°2 • NOVEMBER· 2020

d§ tung gay di ((ng (1,6%) ho~c thuoc clingnhorn voi thuoc gay di ((ng (2,0%).

Nghien cuu cua chung toi cling ghi nhan72,7% tnJ'ong hop str dunq corticoid, 68,2% sU'dunq adrenalin. Con ket qua trong nghien ciru aTrung QUoc, tY I~ benh nhan sU'dunq adrenalinla 59,5%. Trong mQt so nqhlen cuu khac, bienphep dlJ'qc sU' dunq nhieu nha't la corticoid vakhanq histamin Hl, tuy nhien ngoai adrenalincac bi~n phap tren phI,!thuQcvao bieu hi~n phanv~ va cach xU'tri clla bac si nen tY I~ giiIa cacnghien c((u chenh I~ch nhieu. NhlJ'v®y, vi~c daot~o dinh ky nham giup can bQy te t~i cac cd sokham chiIa b~nh nam viIng kien th((c ve phathien va xU'trf la van de can thiet neu muon tangtY 'I~ xU'trf phu h<;1ptren thl/c teo

v. KET LU~NNghien c((u d§ cho thay hinh imh ve thl/c

hanh bao cao lien quan den cac trlJ'ong phan v~ghi nh~n tls'h~ thong bao cao tl/ nguy~n clla Vi~tNam giai do~n 2010-2019 ve d~c diem clla ho~tdQng baa cao, d~c diem clla thuoc nghi ngo vaphan lfng phan v~ dlJ'<;1cghi nh~n cung voi thongtin ve xU'trf t~i ddn vi dieu trj. Ket qua tls' nghienclfu d5 cung cap nhiIng thong tin hiIu fch giupcho vi~c dl/ phong va xU' trJ phan v~ tren lamsang, tuy nhien day la cac bao eao tl/ nguy~nnen khong the tranh du'<;1ehi~n tu'gng bao ca,odu'oi mlfc thl/e teoCan tiep tl,!Cdjnh ky tong ketcae bao cao tl/ nguy~n de cung cap cae bangch((ng cho thl/e hanh gii~mthieu nguy cd tai bien

do phan v~ tat cac don vi dieu trio

TAl LIEUTHAM KHAo1. BOY te (~017~,Thanatu' sO 51/2017{1T-BYTvevi~

" HtJ'angdanphong,chandeanva xU'trl phan v~".2. Le Thj Thuy Linh (2015), "Danh gia sl/ hinh

thanh tin hi~\.Jva cacf xU'tn cac tnlonq hop phanv~ nr dO',li~l!, bao cao ADR tl/ nguy,~n tal Vi~tNam", Luc;tnvan thac si duoc hoc, TrtJ'dngDc;tihocDuoc Ha Nai.

3. Brown S: G. (2004), "Clinical features andseverity grading of anaphylaxis", J Allergy ClinImmunol, 114(2), pp. 371-6.

4. Nguyen K. D., Nguyen H. A., et al. (2019),"Drug-Induced Anaphylaxis in a VietnamesePharmacovigilanceDatabase: Trends and SpecificSignals from a Disproportionality Analysis", DrugSaf, 42(5), pp. 671-682.

5. Uppsala Monitoring Center (2019), "Vigilyze -an instant graphical overview of global data tosupport evaluation of domestic data (avaiable forNational PharmacovigilanceCenters participating inWHO Programme for International DrugMonitoring). Retrieved in Oct 1st 2020 athttps://vigilyze.who-umc.org/", pp.

6. WHO/Uppsala Monitoring Center (2012),"WHOAdverse reactionsTerminology", pp. 8-178.

7. Patel Tejas K, Patel Parvati B, et al. (2014),"Drug-induced anaphylactic reactions in Indianpopulation: A systematic review", Indian journal ofcritical care medicine: peer-reviewed, officialpublication of Indian Society of Critical CareMedicine, 18(12), pp. 796.

8. Ye Young-Min, Kim Mi Kyeong, et al. (2015),"Predictorsof the severity and seriousoutcomesofanaphylaxis in Korean adults: a multicenterretrospective case study", Allergy, asthma &immunology research, 7(1), pp. 22-29.

DAC DIEM NGUCYIB~NH SUY TIM M~N, TINH T~NG LO Au vAKEi QuA CHAM SOC NGUCrI B~NH T~I KHOA TIM M~CH LAo HQC -

BENH VIEN TIM MACH AN GIANG NAM 2020. . .

T6MTAT.Nghien cltu me ta cat ngang tren 209 ngtJ'oi~nh

suy tim mc;tnnh~p vi~n tc;tiB~nh vi~D Tim mc;tchAnGiang(BVTMAG),tu thang 01/2020 den 06/2020. Ml,1cdfch cua nghien cU'utim hieu cac yeu to lien quan den10 au va danh gia ket qua cham soc cua b~nh nhansuy tim nh~ vien tai BVTMAG.Ket qua: Nhom tren60 tuoi chiem (85,60/0), tuoi trung binh72 :I:: 12, nO'

*Tru'ifng Dai Hoc TMng LongChiu trach nhiem chinh: Nguy~nCengThanhEmail: thanhaglx@gmail.comNgaynh~n bai: 28.9.2020Ngayphan bi~n khoa hQc:30.10.2020Ngayduy~t bai: 10.11.2020

328

Nguy~n Cong Thimh*chiem (63,2%), trinh dQ hQcvan < cap 1 (59,8%),nghi htJ'u (85,6%), song 0 nang then (74,6%), thunh~p < 2 tri~u dang/tnang (80,4%), tien sU'suy tim(60,8%). Tinh trc;tngnh~p vi~n co kho tho (54,1%1,nang ngtJ'c(44,5%), phu chi (22%), tinh mc;tchnoi(35,4%).' Hong cau (4,2 :I:: 0,7), Ure (6,8 :I:: 4,8)Creatinin (112,8 :I:: 156,9), Natri (135 :I:: 5,3), Kali (3,4:I:: 0,4), NT ProBNP(2721,7 :I:: 384,5. Suy tim nh~ (I +II) 68%, suy tim n~ng (III + IV) 32%. TV I~ngtJ'oibenh 10 au trong nghien CIIU 55,5%. Sau dfeu tri vacham soc diem trung binh cua tnang diem DASSgiamtU' 9,1 :I:: 0,4 xuong con 3,61 :I:: 0,2 (p < 0,001). Cacyeu to co anh htJ'ongden 10 au bao gam: thu nh~pthap (OR = 2,06; KTC95%= (1,0 - 4,0); P = 0,046),thai gian suy tim > 1 nam {OR = 2,57; KTC95% =(1,4 -4,5); P = 0,001), co mOt dQST n~ng (OR=2,04;

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