Life and Medical Sciences Program

Biological Facilities Support of biological stations at world-class synchrotron & neutron sources, JGI, and ORNL mouse house.

Genomics: GTL Systems biology research in bioenergy, bioremediation and carbon sequestration; development of bioenergy research centers.

Health Effects Research- Low Dose Radiation Program

- Nuclear Medicine

- Advanced bio-medical instrumentation

- ELSI, Human Subjects Protection Program

Office of Science

U.S. Department of Energy

Shewenella FederationShewenella Federation

• Comparative genomic and physiological analysis of Shewenella species.

• Functional genomics energy flow and electron transport.

• Genetic and functional characterization of c-type cytochromes

• Characterization and modeling of metabolic and regulatory networks.

PNL, ANL,ORNL,USC,UCLA,MSU,BU. OU,MBL,DRI,BIATECH,GEONOMATICA

Federation Integrated ApproachFederation Integrated Approachto Shewanella Biologyto Shewanella Biology

ImagingAFM, EM, CLSM

Immuno-EM

ProteomicsMS

2-D gel

MR-1 GenomeSequence,

Bioinformatics

Information Synthesis & Interpretation

Linked measurements

Concepts &Hypotheses

Cellular networks,Modeling

Gene ExpressionMicroarraysReporters

Physiology &Metabolism

Computational Biology

Data Analysis &Integration

▲Perturbation:

•mutation•cultivation

ControlledControlledCultivationCultivation

DOE Imaging InstrumentationDOE Imaging Instrumentation

Clinical PET

MicroPET

Mobile PET

Office of Science

U.S. Department of Energy

Awake Animal Project :The Rat CAP

•Miniaturized, novel electronics which allows the signals from the RatCAP to be collected, amplified and analyzed

•LSO crystal arrays, backed to photodiodes and electronics board.

•Image resolution comparable to micro-PET

RatCAP

MicroPET

Schlyer, Vaska, Woody, 2006

Office of Science

U.S. Department of Energy

•Six 16-electrode devices implanted in humans. Longest implant in for 3 years.

•60 electrode device completing pre-clinical testing in dogs. Human study scheduled for 12/06.

•Component design for 250

electrode device completed.

ORNL, ANL, LANL, SNL, LLNL, BNL, USC, UC SC, CalTech,NC State, Second Sight