Actisaf® is a thermostable live yeast concentrate, selected especially for animal nutrition for more than 30 years by Lesaffre research. The Lesaffre group is a reference in the field of yeast. Particularly well-known for our contributions to the bread-making, brewery and wine-making industries, we also specialize in human and animal nutrition and health care.

Working at the crossroads of nutrition and health, Phileo is committed to delivering innovative evidence-based solutions for improving ruminant health and performance. In every country, our progress is led by the most advanced science as well as practical on-farm experience. Phileo also has a platform in Toulouse, The Farm, dedicated to knowledge sharing and scientific expertise.

To guarantee optimum quality, the Sc 47 strain is carefully grown and transformed into microspherules in compliance with a patented process, in the world’s largest yeast production factory, located in Marcq-en-Baroeul in northern France.

In Europe, Actisaf® is the live yeast authorized for the most species (cattle, small ruminants, pigs, horses and rabbits) and production stages, and it is covered by more than 11 registration dossiers.

• Live yeast concentrate• Exclusive Saccharomyces cerevisiae Sc 47 strain• High thermostability in pelleted feed: up to 92°C

Marcq-en-Baroeul

3-StagE modE of aCtion on rumEn funCtion

There is a close correlation between rumen pH and redox potential (Eh). The pH is used to evaluate rumen acidosis. The Eh reflects the activity and growth of rumen microbiota and varies according to the biochemical reactions taking place. The lower the Eh, the better the balance.

High redox potential (Eh)

Low pHAcetate Butyrate Propionate

Lactate

microflora

CONTROL COW

Low redox potential (Eh)

High pHAcetate Butyrate

microflora

Propionate

Lactate

EnergyProtein

WITH

Actisaf

Lactic acid bacteria

Lactate-utilizing bacteria

Cellulolytic bacteria

5 g of actisaf® is sufficient to stabilize

the 180 l rumen of a dairy cow.“ ”

Improving rumen reducing conditions1

Stimulating fibrolytic and lactate-utilizing bacteria1

Supplementation with Actisaf® significantly reduces the amount of lactate in the rumen, leading to a significant increase in the pH.

Actisaf® decreases the redox potential, thereby optimizing rumen function efficiency.

Actisaf® acts on the flora balance, having an effect on pH equivalent to the buffer capacity of 150 g of bicarbonate.

Scan this code to watch the video and find out more on rumen balance:

Increasing the pH to reduce the risk of acidosis1

1

2

3

EhRedox

-160

-140

-120

-100

-180T-1 T0 T1 T2 T3 T4 T5 T6 T7 T8

-80

E h (m

V)La

ctat

e (m

M)

High oxygen presence

High acidosis risk

1- Marden et al. 2008. How does live yeast differ from sodium bicarbonate to stabilize ruminal pH. J Dairy Sci. 91: 3528-3535.

Low acidosis risk

Low oxygen presence

Flora

16.5

0

5

10

15

20

b b

12.2

5.4

a

*

*p< 0.05

time in hours

5.4

5.6

5.8

6.0

6.2

6.4

T8T-1 T0 T1 T2 T3 T4 T5 T6 T7

6.6

pH

meal

time in hours

actisaf® (5 g/animal/d)

Bicarbonate (150 g/animal/d) Control

actisaf® (5 g/animal/d)

Bicarbonate (150 g/animal/d) Control

pH

meal

actisaf® (5 g/animal/d)

Control

Bicarbonate (150 g/animal/d)

2- Julien, C., Cauquil, L., Combes, S., Bouchez, O., Marden, JP., Bayourthe, C. 2012. Study of the effect of Live Yeast Saccharomyces cerevisiae (CNCM I-4407) on ruminal bacterial community in lactating dairy cows using 454 GS FLX pyrose-quencing. 8th INRA-RRI symposium, 17-20 June 2012, Clermont-Ferrand, France. Principal Component Analysis based on the relative abundance of 177 identified genera. 3- Data on file. 4- European registration trials - 1 505 dairy cows. 5- Data on file.

improving fEEd digEStiBiLity and Harmonizing HErd pErformanCE

improving miLk produCtion and quaLity

Reducing the redox potential with Actisaf® stimulates fibrolytic bacteria for better feed digestibility.

ã Assimilation of fibre1 ã Milk production3

*p <0.05

Dig

estib

ility

(%)

30%

20%

40%

50%

10%Neutral Detergent Fibre Acid Detergent Fibre

+41% *

+77% *

Control actisaf® (5 g/animal/d) Bicarbonate (150 g/animal/d)

• fewer undigested particles in the dung (grains, fibre)• more homogenous dungs

Actisaf® has a stabilizing effect on the rumen environment, significantly homogenizing rumen bacterial populations in the herd.

Improving and stabilizing the rumen function helps to improve animals’ overall health status, resulting in lower cellular levels in milk.

ã Assimilation of feed ã Nutritional concentration4

ã Herd performance2 ã Milk quality5

Control period Period of Actisaf® use

Axis 1

Heterogeneous microbiota Homogeneous microbiota

Axis 1

Axis

2

Axis

2

Control Actisaf® 5 g/animal/d

actisaf® increases milk production

by 1.9 kg/d on average.“

”33

35

43

41

39

37

31

45

United Kingdom

2002

Czech Republic

2003

Spain 2003

Czech Republic

2009

France 2010

Australia 2013

Milk

pro

duct

ion

(kg/

d) Control actisaf® (5 g/animal/d)

Control actisaf®

Control actisaf® (5 g/animal/d)

% o

f con

trol

99

98

100

101

105

104

103

102

97Fat (g/animal/d)

1246

1304

Protein (g/animal/d)

972

1012

SCC

x 10

00/l

50

100

300

250

200

150

350

0France 2011

325

196

Australia 2013

238

132

Italy 2012

304

168

info@phileo.lesaffre.com

137, rue gabriel péri – Bp 302959703 marcq-en-Baroeul - francetel.: +33 320 81 61 00 – fax: +33 320 99 94 82

AC-FARM

-doc.4p-17.01-EN.

The information provided in this docum

ent is, to the best of our knowledge, true and accurate. H

owever, products m

ust be used only in compliance w

ith local laws and regulations and w

e cannot guarantee freedom of use for every

intended application or country. These statements have not been evaluated by the Food and D

rug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

BEnEfitS from BirtH to LaCtation

6- European Actisaf® registration dossier for calves.7- Comparative field trial summary. Data on file.8- Marden et al. 2013. Impact of supplementing a yeast-based product during dry period in post-calving dairy cows. International Symposium, Prague.9- Rodriguez Quiros, 2008. Effect of supplementing the feed of Holstein cows with live yeast (Actisaf®) on the concentration of IgG in the colostrum and the blood of

new-born calves. Thesis.

Bir

tH

WEa

nin

g

inSE

min

atio

n

Ca

Lvin

g

dr

yin

g o

ff

feed transition

• Stabilizing rumen microflora• maintaining production

turnout and grazing

��assimilation of fibre ��Butterfat content

Heat stress ��thermal comfort ��impact of stress

��risk of acidosis

��feed efficiency

��milk production and quality

��Somatic cells

rumen balance and milk production

management of high-risk periods

Phileo developed its “Program Neonate” and “Program Heat Stress” smartphone apps to help dairy farmers evaluate the overall ROI of these programs. They take into consideration a farm’s size and performance criteria.

*Minimum European registration doses:Calf: 0.5 g/animal/d

Dairy cow: 1 g/animal/d1 g of Actisaf® = 10 billion CFU

program

Calf HeIfer laCtatIng CowDry Cow (to prepare for calving)

Dosage 1 to 2 g/animal/d* 5 to 10 g/animal/d 5 g/animal/d

MoDes of aCtIon

anD benefIts

• developping rumen microflora

• Establishing rumen function early on

• assisting growth

��passive immunity transfer from cow to calf

ZOO- teCHnICal

results

+18% adg

-15% fCr6

+1.9 kg of milk/cow/d+5 to 10% protein+5 to 10% fat7

+15% igg in the colostrum8

+39% calf serum igg9

*