Liver as Endocrine - Stuart White

Dr. Stuart White July 26, 2012

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Mentoring the Mentors

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Mentoring the MentorMentoring the Mentor

Stuart White, DC, DACBN, CCNWhole Health Associates1406 VermontHouston, Texas 77006713/[email protected]

www.doctorofthefuture.org

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Mentor goals:

! To declare what is possible and establish a commitment to that possibility

! Address personal and professional barriers limiting the ability to serve

! Evolution of vision/mission/ethics that drive success

! Create immediate action steps to apply learning and growth

! Construct the round table of applied trophologists

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Mentoring the mentor:

! Who are the mentors? – Practitioners

! Who are we mentoring? – Patients and GAP

! What’s the purpose? – Optimized life

! How does it work? – Whatever you learn you teach someone else (anyone else)

! Who’s is included? – Self selection, you pick yourself

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7 Pillars of Healing7 Unified Mechanisms of Health

!Endocrine/Hormonal

!Glycemic Management

!pH Bioterrain

!Inflammatory status

!Immune burdens

!Circulatory Status

!Digestive Potency

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1 -The Endocrine Axis

!Systemic activation of healing and repair

!7 glandular levels

! Estrogen dominance is due to deficient liver cleansing – promote Phase I & II detoxification

!PMG’s first, liver support second, lifestyle modification third, herbal support fourth, HRT final step

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StressorsStressorsStressorsStressors Hormonal/endocrineHormonal/endocrineHormonal/endocrineHormonal/endocrine adaptationadaptationadaptationadaptation Glandular fatigue & imbalanceGlandular fatigue & imbalanceGlandular fatigue & imbalanceGlandular fatigue & imbalance

Depletion of organ reserve and nutrient/mineral substratesDepletion of organ reserve and nutrient/mineral substratesDepletion of organ reserve and nutrient/mineral substratesDepletion of organ reserve and nutrient/mineral substrates

Reduced homeostatic mechanismsReduced homeostatic mechanismsReduced homeostatic mechanismsReduced homeostatic mechanisms

Enhanced physiology/personalityEnhanced physiology/personalityEnhanced physiology/personalityEnhanced physiology/personality

#1 Core Physiologic Principle#1 Core Physiologic Principle#1 Core Physiologic Principle#1 Core Physiologic Principle

Stress hyper/hypo reactivityStress hyper/hypo reactivityStress hyper/hypo reactivityStress hyper/hypo reactivity

Altered psychoneuroimmunologic mechanismsAltered psychoneuroimmunologic mechanismsAltered psychoneuroimmunologic mechanismsAltered psychoneuroimmunologic mechanisms

Restored adaptive mechanismsRestored adaptive mechanismsRestored adaptive mechanismsRestored adaptive mechanisms

Symptoms Symptoms Symptoms Symptoms –––– physical/personality modulationphysical/personality modulationphysical/personality modulationphysical/personality modulation Increased glandular strength/resilienceIncreased glandular strength/resilienceIncreased glandular strength/resilienceIncreased glandular strength/resilience

Disease diagnosis Disease diagnosis Disease diagnosis Disease diagnosis –––– chronic progressionchronic progressionchronic progressionchronic progression

Medical Intervention Medical Intervention Medical Intervention Medical Intervention –––– Drugs & SurgeryDrugs & SurgeryDrugs & SurgeryDrugs & Surgery Increased organ reserve Increased organ reserve Increased organ reserve Increased organ reserve –––– repletion of substratesrepletion of substratesrepletion of substratesrepletion of substrates

DeathDeathDeathDeath

Nutrient Nutrient Nutrient Nutrient repletion repletion repletion repletion ––––

target target target target fortificationfortificationfortificationfortification

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Liver as endocrine:

! The liver is essential to endocrine health as it breaks down conjugated hormones promoting a more accurate body concept of hormonal status

! Estrogen dominance is conceptually seen as a reduction of estrogen synthesis due to a misperceived of abundance when it is not being broken down by the liver – this of course results in a secondary reduction of progesterone production due to the reduced effect of priming the progesterone receptors by estrogen

! The health and efficiency of the liver directly participates in hormonal balance in this way

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Liver as endocrine:

! The liver also synthesizes protein bound iodine which in turn promotes thyroid physiology, so many thyroid imbalances are up-regulated by increasing liver activity

! To attempt to define the liver’s function if futile as it has been estimated at having over 30,000 individual actions

! So rather than trying to describe and support so many different functions it is wiser to view the liver status as essential to overall endocrine balance

! For this reason to achieve balancing endocrine activity in anyone the liver must be supported and addressed

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Liver – Where to begin:

! One of the most popular starting places doctors choose to begin modulating health function is with the SP Purification Program (21 days) – this is in fact a liver detox and unburdening program specifically promoting both Phase I and II detoxification – the liver is cleansed, weight is reduced, and a metabolic/endocrine ‘reboot’ is accomplished

! There are many other ways to gradually and incrementally up-regulate liver status that can be considered as an ongoing way to promote health and transformation

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Liver sequentially enhanced:

! A F Betafood! Choline! Betacol! Livaplex! Livco! Livton! Albizia! Parasite cleansing (Zymex II, Multizyme,

Wormwood)

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Liver cleansing step by step:

! A F Betafood – 10/day - cholagogue promoting bile synthesis and delivery

! Choline – 6/day – begin second month with A F Betafood and further emulsify fats and therefore bile action

! Betacol – 6/day – Follow A F Betafood program with this promoting cleansing of highly alkaline guanidine from liver

! Collinsonia Root – 6/day – Promotes increased vascular dilation in hepatic and peripheral circulation – very useful in reducing liver congestion

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Liver cleansing step by step:

! Livaplex – 6/day – combination product including A F Betafood, Hepatrophin, Betacol, Spanish Black Radish, Chezyn, Antronex – used for general liver support and cleansing and may be seen as a next step to liver sequential up-regulation

! Livco – 4/day – Promotes Phase I & II detoxification and helps with viral burdens in the liver

! Livton – 4/day – Promotes bile production and delivery (cholagogue) supporting normal digestive actions and preventing bile and bowel stasis

! Albizia – 4/day – Supports the Kupfer cells in the liver which release histamine and thus reduce histaminic burden and body sensitivity

Estrogen Dominance - Widespread! Defined as deficient, normal, or excessive levels of

estrogen with too little progesterone to balance the estrogen – common in both cycling and menopausal women, and andropausal men

!Caused by cortisol(pregnenelone) steal, HRT & BC pill, adrenal fatigue, hypothyroidism, high glycemic diet, trans-fatty acids, xenoestrogens, obesity (estrogen is made in the fat cells)

!Symptoms may include: anxiety, anger, agitation, mood swings, depression, dysmenorrhea, water retention, fibrocystic breasts & tenderness, migraines, food cravings, fibromyalgic discomfort, acne, loss of mentation, mid-body fat gain, cold extremities (estrogen blocks thyroid), dysglycemia, loss of libido, infertility, insomnia, osteoporosis, PCOS, uterine fibroids, autoimmunity, breast or uterine cancer

Estrogen – Ultimate Phase I/II Detoxification! For hormones to dance with other hormones it must have a flexible

response pattern = be able to increase/decrease rapidly

! Estrogen building up imbalances menstruation, pregnancy, lactation (following menopause dance continues to prolong life, supporting structural, cardiac, and neurological functions)

! Cytochrome P450 enzyme system is used to eliminate drugs, toxins, unwanted substances, biological agents, and estrogens – body views estrogen as a toxin because it allows such a small number of estrogen molecules to be active, unlike testosterone, DHEA, progesterone

! Phase I (P450) – oxidation, reduction, hydrolysis, hydration, dehalogenation = increased polarity, less lipid-soluble, reactive oxygen intermediates with potential for secondary tissue damage “sticky reactive molecules” (antioxidant needs)

! Phase II – sulfation, methylation, glucuronidation = polar water-soluble bile and urine (sulfation, homocysteine support, and gut symbiotic bacteria + soluble fiber are essential fuels)

! Phase III (Antiporter) – a recirculation process not yet accepted scientifically, active efflux pump decreasing intracellular concentration of xenobitoics allowing for a “second-pass” with the detox enzymes located at or near the cell membrane (more concentrated presence in cancer cells, liver, kidney, pancreas, intestines, brain, testes)

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Detox – Phase I & II

Textbook of Functional Medicine: David S. Jones, Institute for Functional Medicine: Gig Harbor, WA.: Page 278

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Effects of Estrogens

!Tissue Proliferative Effects

!Breast tissue proliferation

!Vaginal tissue proliferation

!Skin, nail, and hair proliferation

!Parietal cells (HCL)

!Other Effects

!Antagonist effects on proinflammatory transcriptional factors

!Modulation of nitric oxide

!Direct antioxidative effects

! Immune system modulation

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Conditions that Increase in Risk with Perimenopause and Menopause

!Cardiovascular Disease and Stroke

!Osteoporosis

!Dementia and Alzheimer’s

!Arthritis

!Autoimmune Disease

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!If there is a decline in estradiol levels in a female

patient in perimenopause the inflammatory cytokine system

is upregulated and may stay upregulated even after estrogen levels are restored.

Phase I & II

detoxification

occur principally in

the liver, while Phase I, II, &

III occur in

every cell – the liver

determines the foundational

capacity to

cleanse

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The secret formula for encouraging a healthy 2 to 16 ratio! 1-O-FERULOYL-BETA-D-GLUCOSE Leaf:

! 1-O-P-COUMAROYL-BETA-D-GLUCOSE Leaf:

! 1-O-P-SINAPOYL-BETA-D-GLUCOSE Leaf:

! 2-HYDROXY-BUT-3-ENYL-GLUCOSINOLATE Leaf:

! 4-METHOXY-INDOL-3-YL-METHYL-GLUCOSINOLATE Leaf:

! ALLYL-ISOTHIOCYANATE Seed:

! ALPHA-LINOLENIC-ACID Leaf 990 - 7,069 ppm

! ALPHA-TOCOPHEROL Leaf 4 - 63 ppm

! ANTEISO-HEPTACOSAN-1-OL Flower:

! ANTEISO-MONTANYL-ALCOHOL Leaf:

! ANTEPENTACOSAN-1-OL Leaf:

! ARACHIDONIC-ACID Leaf 10 - 71 ppm

! ARGININE Leaf 2,030 - 14,494 ppm

! ASCORBIC-ACID Leaf 720 - 6,069 ppm

! ASH Leaf 13,700 - 97,818 ppm

! BETA-CAROTENE Leaf 5 - 41 ppm

! BORON Leaf 57 ppm; Stem 21 ppm;

! CAFFEIC-ACID Leaf 34 ppm;

! CALCIUM Leaf 395 - 3,177 ppm

! CARBOHYDRATES Leaf 89,600 - 639,744 ppm

! CITRIC-ACID Leaf:

! COPPER Leaf 1 - 5 ppm

! COUMESTROL Shoot 400 ppm;

! CYSTINE Leaf 220 - 1,571 ppm

! FAT Leaf 2,000 - 28,560 ppm

! FERULIC-ACID Leaf 10 ppm;

! FIBER Leaf 15,100 - 107,814 ppm

! FOLACIN Leaf 0.56 - 4 ppm

! FUMARIC-ACID Leaf:

! HEPTACOSAN-1-OL Flower:

! HEXACOSAN-1-OL Leaf:

! HISTIDINE Leaf 760 - 5,426 ppm

! INDOLE-3-ACETONITRILE Shoot:

! INDOLE-3-CARBINOL Shoot:! INDOLE-3-CARBOXALDEHYDE Shoot:

! INDOLE-3-CARBOXYLIC-ACID Shoot:

! INDOYL-3,3'-DIMETHANE-CARBOXYLIC-ACID Shoot:

! IRON Leaf 9 - 136 ppm

! ISOHEXACOSAN-1-OL Leaf:

! ISOLEUCINE Leaf 1,320 - 9,425 ppm

! ISOOCTACOSAN-1-OL Leaf:

! KILOCALORIES Leaf 430 - 3,070 /kg

! LEUCINE Leaf 1,520 - 10,853 ppm

! LINOLEIC-ACID Leaf 450 - 3,213 ppm

! LYSINE Leaf 1,540 - 10,996 ppm

ISOHEXACOSAN-1-OL Leaf:

ISOLEUCINE Leaf 1,320 - 9,425 ppm

ISOOCTACOSAN-1-OL Leaf:

KILOCALORIES Leaf 430 - 3,070 /kg

LEUCINE Leaf 1,520 - 10,853 ppm

LINOLEIC-ACID Leaf 450 - 3,213 ppm

LYSINE Leaf 1,540 - 10,996 ppm

MAGNESIUM Leaf 230 - 1,642 ppm

MALIC-ACID Leaf:

MANGANESE Leaf 3 - 24 ppm

METHIONINE Leaf 320 - 2,285 ppm

MOLYBDENUM Leaf 0.9 ppm; Stem 0.36 ppm;

MONTANYL-ALCOHOL Leaf:

NIACIN Leaf 6 - 64 ppm

OCTACOSAN-1-OL Leaf:

OLEIC-ACID Leaf 190 - 1,357 ppm

OXALATE Leaf 3,600 - 25,704 ppm

P-COUMARIC-ACID Leaf 12 ppm;

PALMITIC-ACID Leaf 530 - 3,784 ppm

PALMITOLEIC-ACID Leaf 20 - 142 ppm

PANTOTHENIC-ACID Leaf 3.1 - 22 ppm

PENTACOSAN-1-OL Leaf:

PHENYLALANINE Leaf 980 - 6,997 ppm

PHOSPHORUS Leaf 690 - 4,927 ppm

PHYTOSTEROLS Leaf 240 - 1,710 ppm

POTASSIUM Leaf 3,670 - 29,343 ppm

PROP-2-ENYL-GLUCOSINOLATE Leaf:

PROTEIN Leaf 32,580 - 250,000 ppm

QUERCETIN Sprout Seedling 25 ppm;

QUINIC-ACID Leaf:

RIBOFLAVIN Leaf 0.4 - 10 ppm

RUTIN Shoot 20 ppm;

SEC-BUTYL-ISOTHIOCYANATE Seed:

SELENIUM Leaf 0.024 ppm; Stem 0.012 ppm;

SINAPIC-ACID Leaf 107 ppm;

SODIUM Leaf 221 - 1,990 ppm

STEARIC-ACID Leaf 30 - 214 ppm

SUCCINIC-ACID Leaf:

TETRACOSAN-1-OL Leaf:

THIAMIN Leaf 1.3 - 11 ppm

THREONINE Leaf 1,200 - 8,568 ppm

TRIACONTAN-1-OL Leaf:

TRYPTOPHAN Leaf 370 - 2,642 ppm

VALINE Leaf 1,550 - 11,067 ppm

VIT-B-6 Leaf 2.2 - 16 ppm

WATER Leaf 846,000 - 945,500 ppm

ZINC Leaf 10 - 157 ppm

Brussel Sprouts

Cruciferous Complete

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Detox – Phase I & II

Textbook of Functional Medicine: David S. Jones, Institute for Functional Medicine: Gig Harbor, WA.: Page 278

Needs Homocysteine

support, B2, B3, B6, Glutathione, AA, Flavonoids, Phospholipids

Needs Homocysteine

support, Glycine, Taurine,

Glutamine, NAC, Cysteine,

Methionine

Stepping Forward

It is doing and not simply knowing

Risking based on reason

Passion because of possibility

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Case Study – SteveAuto-immune resolution

! 37 years old,

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Megan – Autoimmune, ADD, Addict

! Presented 10/10 for IBS, Rheumatoid Arthritis, ADD

and insomnia. Tried everything and finally ended up taking methyltrexate, Vivance and Folic Acid –Symptom free in two months, and in five months no longer wants to smoke – no suggestions just biochemical platform to live from

!Biochemistry changes the choices we think we are making

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Bone health –

A circulatory perspective:

! The classic view of osteoarthritis(OA) and bone health status is based on the concept of demineralization and yet this does not address the localized effect of OA and the resistive response in the nutritional patient

! So this discussion will speculate about a different etiology for OA and bone health – which does seem to respond quickly to nutritional intervention

! This is first based on ideas elaborated by Kerry Bone and subsequent application of these perspectives clinically with many patients and outcomes observed

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Bone circulation:! An Australian researcher was developing a large

computer model database – he queried it with certain risk factors known to associate with the typical vascular issues of incidence in the society (e.g. – Type A personality, smoking) – he expected the computer model to show a certain percentage of vascular heart disease – it did – but it also revealed an incidence of OA 400% greater than CAD – so he sought cadaver confirmation of what the statistics were suggesting

! The osseous microvasculature supplying blood to the bone was plaqued and blocked in OA suggesting a loss of nutrient supply to the bone for ongoing osteoblastic buildup

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Bone circulation:! This in turn resulted in a osteonecrosis and bone

compression and then the characteristic hypertrophic lipping and spurring in response

! Because the vascular pathways supplying blood to bone is through hard channels incapable of dilation the bone clinically shows vascular obstruction 4 times more than the heart

! So with vascular renewal programs and oral chelation efforts reduction in OA symptoms are able to be observed within 3-4 weeks, with therapeutic intervention requiring 3-6 months to achieve maximal improvement

! Remember bone remodeling has a half life of 5 years, and thus changes can be expected for at least that time

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Bone circulation protocol:! Oral chelation:

!Garlic Forte 2/day!Cayenne 2/day!Cyruta 6/day

! Promoting osteoblastic remodeling:!Biost 6/day!Cataplex D 6/day!Gotu Kola Complex 2/day!Bone Complex 2/day

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Review - Therapeutic Rationale• This is the reason why we do and don’t do• Therefore it is the reason why the patient will do or not what you recommend• It is the source of hope and the starting place• The functional practitioner serves from this rationale in all endeavors, and it becomes the practice style – making incursions into disease conditions based on a rationale and an accountable procedure• this expands the practice and builds practitioner confidence• Have a reason for what you recommend!

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Sequential Intervention

! By giving hope through discussion of therapeutic rationale and then accountably determine if the therapy had efficacy it is possible to initiate activity that may assist a person to make the changes that result in healing

! Sequential intervention and accountable follow-up can show what has worked and what may still need to be employed

! Sequentially detoxify the liver to promote endocrine balance

! Allow every condition to become a strategic consideration of possible etiology and therapeutic rationale – people are in search of experts – reveal yourself

! The comprehensive nature of nutritional therapy means there is always more physiology to optimize and support leaving an individual constantly refining as long as they wish to further improve their status

! If the practitioner is accountable s/he will be allowed to experiment with reasonable ideas

38

Change the world

It wants to

Change the world

It wants to

Page 11

Purification & Weight Management

800-848-5061www.standardprocess.com

L3700

© 2005 Standard Process Inc. All Rights Reserved. 07/05

Refresh. Replenish. Rejuvenate.Purification and Weight Management Programs

Founded in 1929 by Dr. Royal Lee,

Standard Process has been a leader in the field

of natural whole food supplements for more than 75

years. Dr. Royal Lee believed that, “The quality of a

whole food supplement is dependent on the quality of

the manufacturing process.” This remains the

foundation of the Standard Process doctrine today.

Owned and operated by relatives of Dr. Lee,

Standard Process manufactures its supplements from

start to finish at its facility located in the heartland of

America: Palmyra, Wisconsin. Beginning at the

company’s 1,000 acres of farmland and continuing

through the final stages of our unique processing,

Standard Process provides the highest

quality food supplements available.

The History & Principles OfStandard Process

Page 12

Challenging? Of course. Rewarding? Absolutely.

What is Purification?Purification is merely the internal cleansing and

detoxification of your body. Think of it as

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It requires making new, healthier choices for yourself. You

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Depending upon the program you choose, you may find

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*These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Your Body’s Junk DrawerYou probably have a junk drawer at home.

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Page 13

Please copy for your patients.

800-558-8740 | standardprocess.com†These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

A-F Betafood®

Contains Many Nutrients, Including Betaine, to Protect the Liver and Enhance Its Function

The whole food beet ingredients in A-F Betafood contain two important

phytonutrients, betalains and betaine, to support and protect the liver. Betalains

are the pigments found in beets that are generally protective to the liver and

colon and also protect the body against oxidative stress. Betaine has been shown

in laboratory and animal studies to protect cells, proteins, and enzymes from

environmental stress and support important metabolic functions of the liver and

kidneys. A-F Betafood also contains many essential vitamins and minerals to

support overall healthy functioning of the liver and the body.†

How A-F Betafood Keeps You Healthy

Promotes healthy liver function

The betaine in A-F Betafood is an effective lipotrophic agent, which promotes

the transportation and use of fats, helping to prevent the accumulation of fat in

the liver.†

Maintains healthy metabolic function

The B-vitamin complex, found in nutritional yeast, is a family of vitamins that

work together to metabolize fats, carbohydrates, and proteins. Vitamin B6

supports the metabolism of carbohydrates by facilitating glycogen breakdown.

Iodine is required to produce the two hormones in the thyroid gland responsible

for regulating the body’s rate of metabolism, reproductive functions, and growth

and development. Magnesium is needed to metabolize carbohydrates and fats

for energy, and is a cofactor for ATP metabolism. ATP is needed to produce the

energy that is required for metabolic processes throughout the body.†

Provides many essential nutrients to support overall health

Calcium and magnesium are essential to bone health and several enzymatic

reactions in the body. Calcium is necessary for blood coagulation,

vasoconstriction and vasodilation, nerve impulse transmission, muscle

contraction, hormone secretion, maintenance and function of cell membranes,

and membrane permeability. Magnesium supports DNA synthesis, the synthesis

of the antioxidant enzyme glutathione, and the transport of ionizable calcium

and potassium across cell membranes.†

Promotes cellular health

Beets are rich in folate, a nutrient that supports the production and maintenance

of new cells. Potassium maintains cell-membrane integrity. Vitamin A supports

healthy cellular growth and helps the body maintain healthy mucous membranes.

Vitamin B6 supports the formation and function of red blood cells. The essential

fatty acids (EFAs), like those found in flaxseed oil, mixed tocopherols, and soybean

lecithin, support cell structure.†

A-F B

etafood®

Introduced in 1951

Content: 90 tablets 360 tablets

Suggested Use: Two tablets per meal, or as directed.

Supplement Facts: Serving Size: 2 tablets Servings per Container: 45 or 180 Amount per Serving %DV

Calories 2

Total Carbohydrate 1 g <1%*

Sugars 1 g

Vitamin A 3,000 IU 60%

Vitamin B6 0.3 mg 15%

Iodine 40 mcg 25%

*Percent Daily Values (DV) are based on a 2,000-calorie diet.

Proprietary Blend: 546 mg Carrot (root), beet (root), oat flour, dried beet (leaf) juice, defatted wheat (germ), calcium lactate, magnesium citrate, bovine liver, nutritional yeast, bovine kidney, bovine prostate, alfalfa flour, bovine orchic extract, bovine liver-fat extract, flaxseed-oil extract, mixed tocopherols (soy), and soybean lecithin.

Other Ingredients: Honey, calcium stearate, arabic gum, starch, sucrose (beets), vitamin A palmitate, prolamine iodine (zein), ascorbic acid, and pyridoxine hydrochloride.

Two tablets supply approximately: 170 mg beet-leaf juice and beet powder and 130 mg carrot powder.

Warning: Women who are pregnant, may become pregnant, or are lactating should limit their intake of vitamin A (retinol) and use vitamin A products only as directed by a qualified health care professional. Consumption of large amounts of vitamin A (retinol) has been linked to serious health problems.

Sold through health care professionals.

Page 14

800-558-8740 | standardprocess.com©2008 Standard Process Inc. ©2012 Standard Process Inc. (This is a subsequent edition of the work published in 2008.) All rights reserved. T0775 1/12

A-F Betafood®

What Makes A-F Betafood Unique

Product AttributesIngredients are derived from whole food sources

�i The combination of whole foods along with their vitamin complexes promotes the healthy transport and metabolism of blood fats and supports healthy processing of fats in the liver

�i The minerals and vitamins present in beets work together with other ingredients in A-F Betafood to promote healthy liver metabolism and cellular function

�i Carrot root and beet root and juice provide naturally occurring antioxidants, vitamins, and betaine†

Multiple nutrients from a variety of plant and animal sources

�i Extracts from bovine tissues provide nutrients and support to the corresponding tissues in humans

�i Vitamins, minerals, and nutrients from plants and animal tissues work synergistically for maximum effect†

Certified Organic FarmingA healthy ecosystem is created by using organic farming techniques, such as rotating crops, fertilizing the soil with nutrient-rich cover crops and byproducts from our processing, practicing strict weed-control standards, and continually monitoring the health of our plants

�i Assures the soil is laden with minerals and nutrients

�i Ensures plants are nutritionally complete and free from synthetic pesticides

Manufacturing and Quality-Control ProcessesUpon harvesting, nutrient-rich plants are immediately washed and promptly processed

�i Preserves nutritional integrity

Low-temperature, high-vacuum drying technique

�i Preserves the enzymatic vitality and nutritional potential of ingredients

Not disassociated into isolated components

�i The nutrients in A-F Betafood are processed to remain intact, complete nutritional compounds

Degreed microbiologists and chemists in our on-site laboratories continually conduct bacterial and analytical tests on raw materials, product batches, and finished products

�i Ensures consistent quality and safety

Vitamin and mineral analyses validate product content and specifications

�i Assures high-quality essential nutrients are delivered

Whole Food PhilosophyOur founder, Dr. Royal Lee, challenged common scientific beliefs by choosing a holistic approach of providing nutrients through whole foods. His goal was to provide nutrients as they are found in nature—in a whole food state where he believed their natural potency and efficacy would be realized. Dr. Lee believed that when nutrients remain intact and are not split from their natural associated synergists—known and unknown—bioactivity is markedly enhanced over isolated nutrients. Following this philosophy, even a small amount of a whole food concentrate will offer enhanced nutritional support, compared to an isolated or fractionated vitamin. Therefore, one should examine the source of nutrients rather than looking at the quantities of individual nutrients on product labels.

Studies on nutrients generally use large doses and these studies, some of which are cited below, are the basis for much of the information we provide you in this publication about whole food ingredients. See the supplement facts for A-F Betafood®.

Craig SA. Betaine in human nutrition. Am J Clin Nutr. 2004 Sep;80(3):539-49.

Food and Nutrition Board Institute of Medicine. (1997). Calcium. In Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride (pp. 71-145). Washington D.C.: National Academy Press.

Food and Nutrition Board Institute of Medicine. (1997). Magnesium. In Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride (pp. 190-249). Washington D.C.: National Academy Press.

Food and Nutrition Board, Institute of Medicine. Folic Acid. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B

6, Vitamin

B12

, Pantothenic Acid, Biotin, and Choline. Washington, D.C.: National Academy Press; 1998:193-305.

Food and Nutrition Board, Institute of Medicine. Potassium. In Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate. Washington, D. C.: National Academies Press; 2004:173-246.

Gliszczynska-Swiglo, A, Szymusiak, H, and Malinowska, P. Betanin, the main pigment of red beet: molecular origin of its exceptionally high free radical-scavenging activity. Food Addit Contam, 2006. 23(11): p. 1079-87.

Hetzel, B. S., Clugston, G.A. (1999). Iodine. In M. Shils, Olson, J.A., Shike, M., Ross, A.C. (Ed.), Modern Nutrition in Health and Disease (9th ed., pp. 253-264). Baltimore: Williams & Wilkins.

Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, D. C.: National Academies Press; 2002.

Kanner, J, Harel, S, and Granit, R. Betalains--a new class of dietary cationized antioxidants. J Agric Food Chem, 2001. 49(11): p. 5178-85.

Lee, CH, Wettasinghe, M, Bolling, BW, Ji, LL, and Parkin, KL. Betalains, phase II enzyme-inducing components from red beetroot (Beta vulgaris L.) extracts. Nutr Cancer, 2005. 53(1): p. 91-103.

Leklem JE. Vitamin B6. In: Machlin L, ed. Handbook of Vitamins. New York:

Marcel Decker Inc; 1991:341-378.McCormick DB. Vitamin B

6. In: Bowman BA, Russell RM, eds. Present

Knowledge in Nutrition. Vol. I. Washington, D.C.: International Life Sciences Institute; 2006:269-277.

Peterson LN. Potassium in nutrition. In: O’Dell BL, Sunde RA, eds. Handbook of nutritionally essential minerals. New York: Marcel Dekker, Inc; 1997:153-183.

Ross AC. Vitamin A and retinoids. In: Shils M, ed. Nutrition in Health and Disease. 9th ed. Baltimore: Williams & Wilkins; 1999:305-327.

Trumbo, P., Yates, A. A., Schlicker, S., & Poos, M. (2001). Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. J Am Diet Assoc, 101(3), 294-301.

Page 15


800-558-8740 | standardprocess.comGF This product contains less than 10 parts per million of gluten per serving size or less than 20 parts per million per the suggested use listed on each product label. V Vegetarian (Lacto-ovo)

†These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

CholineHelps Your Body Metabolize Fats and Support Nervous System Function

Choline is an important “vitamin-like” substance that makes up a large portion

of all cell membranes and is necessary for the body to transport different fats in

the bloodstream. Choline is especially known for its ability to help keep the liver

free from fatty buildup. Choline is also a key component of two important

elements of the nervous system, acetylcholine and sphingomyelin, both

necessary for the normal functioning of the nervous system.†

How Choline Keeps You Healthy

Supports healthy nervous system function

Choline and calcium are needed to transmit nerve impulses from the brain

throughout the central nervous system. Choline enhances brain function

and memory.†

Keeps your heart and liver healthy

Fat is automatically transported out of the liver during the same process in

which choline becomes lecithin. The primary function of choline is to

metabolize fats throughout the body.†

Maintains cellular health

Choline furnishes an essential structural component of many biological

membranes. Choline donates methyl groups that are necessary in order to

synthesize other important compounds needed for various physiological

processes.†

Ch

oline

Introduced in 1947 GF V

Content: 90 tablets

Suggested Use: One tablet per meal, or as directed.

Supplement Facts: Serving Size: 1 tablet Servings per Container: 90 Amount per Serving %DV

Calories 2

Choline 175 mg

Ingredients: Choline bitartrate, honey, and calcium stearate.

Excellent source of choline.



Page 16

800-558-8740 | standardprocess.com

CholineWhat Makes Choline Unique

Product AttributesA supplement form of choline provides consistent bioavailability

�i Choline levels vary considerably in food, making it difficult to determine the amount of choline actually available for utilization by the body†

Manufacturing and Quality-Control ProcessesDegreed microbiologists and chemists in our on-site laboratories continually conduct bacterial and analytical tests on raw materials, product batches, and finished products




Studies on nutrients generally use large doses and these studies, some of which are cited below, are the basis for much of the information we provide you in this publication about whole food ingredients. See the supplement facts for Choline.

Anderson L.E. 1998. Mosby’s Medical, Nursing, & Allied Health Dictionary. 5th ed. Mosby: St. Louis. 246, 326.

Balch J.F., Balch P.A. 1997. Prescription for Nutritional Healing. 2nd ed. Avery Publishing Group: Garden City Park. 17, 23, 55.

Berdanier C.D. 1995. Advanced Nutrition Micronutrients. CRC Press: Boca Raton.130-133,158-172.

Blusztajn J.K., et al. Imprinting of hippocampal metabolism of choline by its availability during gestation: implications for cholinergic neurotransmission. Paris Journal of Physiology. Jun-Aug 1998; 92(3-4): 199-203.

Caamano J., et al. Effects of CDP-choline on cognition and cerebral hemodynamics in patients with Alzheimer’s disease. Methods Find Exp Clin Pharmacol. Apr 1994; 16(3): 211-218.

Corona GL., et al. Clincal and biochemical responses to therapy in Alzheimer’s disease and multi-infarct dementia. Eur Arch Psychiatry Neurol Sci. 1989; 239(2): 79-86.

Darvesh S., et al. Cholinesterases in cardiac ganglia and modulation of canine intrinsic cardiac neuronal activity. Journal of the Autonomic Nervous System. Jul 15 1998; 71(2-3): 75-84.

Denda A., et al. Inhibition by piroxicam of oxidative DNA damage, liver cirrhosis and development of enzyme-altered nodules caused by a choline-deficient, L-amino acid-defined diet in rats. Carcinogenesis. Oct 1997; 18(10): 1921-1930.

Denda A., et al. Prevention by inhibitors of arachidonic acid cascade of liver carcinogenesis, cirrhosis and oxidative DNA damage caused by a choline-deficient, L-amino acid-defined diet in rats. Mutation Research. Jun 18 1998; 402(1-2): 279-288.

Emmert J.J., et al. Hepatic betaine-homocysteine methyltransferase acitivity in the chicken is influenced by dietary intake of sulfur amino acids, choline and betaine. Journal of Nutrition. Aug 1996; 126(8): 2050-2058.

Geiger J., et al. The effect increased choline levels on the synthesis and release of acetycholine in heart atria in white rats. Bratisl Lek Listy. Dec 1992; 93(12): 610-614.

Ghoshal A.K. New insight into the biochemical pathology of liver in choline deficiency. Critical Review of Biochemical Molecular Biology. 1995; 30(4): 263-273.

Giovannini M.G., et al. Effect of subchronic treatment with metrifonate and tacrine on brain cholinergic function in aged F344 rats. European Journal of Pharmacology. Jul 31 1998; 354(1): 17-24.

Hacker H.J., et al. Pyruvate kinase isoenzyme shift from L-type to M2-type is a late event in hepatocarcinogenesis induced in rats by a choline-deficient/DL-ethionine-supplemented diet. Carcinogenesis. Jan 1998; 19(1): 99-107.

Holmes-McNary M.Q., et al. Choline and choline esters in human and rat milk and in infant formulas. American Journal of Clinical Nutrition. Oct 1996; 64(4): 572-56.

Kenney J.L., Carlberg K.A. The effect of choline and myo-inositol on liver and carcass fat levels in aerobically trained rats. International Journal of Sports Medicine. Feb 1995; 16(2): 114-116.

Kobayashi E., et al. Inhibitory effects of N,N’-diphenyl-p-phenylenediamine on the early stage of the enhanced hepatocarcinogenesis caused by coadministration of ethionine and a choline-deficient L-amino acid-defined diet in rats. Exp Toxicol Pathol. Jun 1996; 48(4): 275-282.

Lindmar R., et al. Characterization of choline efflux from the perfused heart at rest and after muscarine receptor activation. Naunyn Schmiedibergs Arch Pharmacol. Mar 1986; 332(3): 224-229.

Machlin L.J. 1984. Handbook of Vitamins. Marcel Dekker, Inc.: New York. 550-561.

Mock T., et al. Effects of fatty acids on phosphatidylcholine biosynthesis in isolated hamster heart. Biochemical Cellular Biology. May 1986; 64(5): 413-417.

Nakae D., et al. Production of both 8-hydroxydeoxyguanosine in liver DNA and gamma-glutamyltransferase-positive hepatocellular lesions in rats given a choline-deficient, L-amino acid-defined diet. Japanese Journal of Cancer Research. Nov 1990; 81(11): 1081-1084.

Pieri C. Chronic choline treatment improves the in vivo membrane permeability of old hepatocytes to Rb+. Boll Soc Ital Biol Sper. Oct 1989; 65(10): 909-915.

Pitchford P. 1993. Healing with Whole Foods. North Atlantic Books: Berkeley. 122, 177-185.

Rabkin S.W. Effect of exogenous CDP-choline on choline metabolism in isolated adult rat ventricular myocytes under normoxic and hypoxic conditions. Cellular Biochemical Function. Jun 1993; 11(2): 137-143.

Rabkin S.W. Effects of chlorpromazine and trifuluoperazine on choline metabolism and phosphatidylcholine biosynthesis in cultured chick heart cells under normoxic and anoxic conditions. Biochemical Pharmacology. Jul 15 1989; 38(14): 2349.

Sandmann J., et al. The effects of phorbol esters on choline phospholipid hydrolysis in heart and brain. European Journal of Pharmacology. Mar 13 1990; 188(2-3): 89-95.

Sardesai V.M. 1998. Introduction to Clinical Nutrition. Marcel Dekker, Inc.: New York. 79-84, 233-235.

Scheider W.L. 1983. Nutrition, Basic Concepts and Applications. McGraw-Hill Book Company: New York. 202-203, 222-224.

Sesca E., et al. Choline feeding depresses the phospholipase C activity in the regenerating liver of female rats. Boll Soc Ital Biol Sper. Nov-Dec 1996; 72(11-12): 325-329.

Sesca E., et al. The delay in rat liver regeneration by choline is associated to alteration in C-myc expression. Boll Soc Ital BiolSper. Jul-Aug 1996; 72(7-8): 217-222.

Sheard N.F., et al. Plasma choline concentration in humans fed parenterally. American Journal of Clinical Nutrition. Feb 1986; 43(2): 219-224.

Sheard N.F., Zeisel S.H. Choline: an essential dietary nutrient? Nutrition. Jan-Feb 1989; 5(1): 1-5.

Shils M.E., Young V.R. 1988. Modern Nutrition in Health and Disease. 7th ed. Lea & Febiger: Philadelphia. 142-154, 440-449.

Shinozuka H., et al. Choline deficiency and chemical carcinogenesis. Adv Exp Med Biol. 1986; 206, 253-267.

Sugiyama T., et al. Enhancing effect of a choline-deficient diet on alterations of hepatic drug-matabolizing enzymes ini hepatitis- and hepatoma-predisposed rats (LEC rats). Japanese Journal of Cancer Research. Apr 1991; 82(4): 390-396.

Tamura K., et al. Inhibition by N-(4-hydroxyphenyl) retinamide and all-trans-retinoic acid of exogenous and endogenous development of putative preneoplastic, glutathione S-transferase placental form-positive lesions in the livers of rats. Carcinogenesis. Nov 1997; 18(11): 2133-2141.

Tsujiuchi T. Increased telomerase activity in hyperplastic nodules and hepatocellular carcinomas induced by a choline-deficient L-amino acid-defined diet in rats. Japanese Journal of Cancer Research. Nov 1996; 87(11): 1111-1115.

Tver D.F., Percy R. 1989. The Nutrition and Health Encyclopedia. 2nd ed. Van Nostrand Reinhold: New York. 117-118, 86-88, 266.

Unelius L., et al. Choline+ is a low-affinity ligand for alpha 1-adrenoceptors. Journal of Biochemical Pharmacology. Oct 7 1994; 48(7): 1519-1523.

West Suitor C.J., Crowley F., Merrily R.N. 1984. Nutrition, Principles and Application in Health Promotion. 2nd ed. J.B. Lippincott Company: Philadelphia. 49, 65-66.

Wilson E.D., Fisher K.H., Fuqua M.E. 1965. Principles of Nutrition. 2nd ed. John Wiley & Sons: New York. 136-150, 308-309.

Yokota K., et al. Effects of a choline-deficient diet and a hypolipidemic agent on single glutathione S-transferase placental form-positive hepatocytes in rat liver. Japanese Journal of Cancer Research. Feb 1990; 81(2): 129-134.

©1999 Standard Process Inc. ©2012 Standard Process Inc. (This is a subsequent edition of the work published in 1999.) All rights reserved. T2565 1/12

Page 17



Betacol®

Promotes Healthy Liver, Cardiovascular, and Cellular Function

Betacol contains Tillandsia usneoides, a source of important phytochemicals that

contribute to cardiovascular and cellular health. Several bioactive compounds,

including vitamin C, carotene, and 3-hydroxy-3-methylglutaric acid (HMG), are

found in Tillandsia usneoides. Vitamins, minerals, and phytochemicals in Betacol

work at the cellular level to maintain healthy blood glucose and cholesterol levels

in individuals with normal levels. Betaine in Betacol is important for healthy

liver function, especially the metabolism of fat.†

How Betacol Keeps You Healthy

Promotes healthy liver function

Betaine is a lipotrophic agent that promotes transportation and metabolism of

fats, helping to prevent the accumulation of fat in the liver. Several studies

demonstrate betaine’s unique ability to support a healthy liver.†

Supports cardiovascular health

Tillandsia usneoides supports arterial health by helping to maintain normal

serum cholesterol levels in individuals with normal levels. HMG, the bioactive

compound in Tillandsia usneoides, has been shown in several studies to help

support cardiovascular health factors. Several studies have confirmed that HMG

operates at the enzymatic level in the kidney and intestine. Studies also indicate

that HMG may help maintain healthy cardiovascular function. Betacol contains

vitamin B6, which is important for red-blood-cell formation and helps maintain

optimum homocysteine levels in the blood. Vitamin B6 is well documented for

its ability to support the heart muscle and associated blood vessels.†

Promotes healthy cellular function

Vitamin B6 is required to synthesize the nucleic acids RNA and DNA—the

molecules that carry the genetic instructions for normal cellular growth and

reproduction. Betacol also contains niacin, which functions as a coenzyme that is

key to cellular respiration, carbohydrate and protein metabolism, and lipid

synthesis. Niacin is a hydrogen acceptor, combining with hydrogen atoms as they

are removed from the food we eat. Once this occurs, the coenzyme continues

transferring these atoms to other compounds in a series of complex oxidation

reactions. Several studies indicate that extracts from Tillandsia usneoides contain

compounds capable of reducing serum glucose. HMG may also help support

liver function.†

Betacol ®

Introduced in 1946

Content: 40 capsules

Suggested Use: One capsule per meal, or as directed.

Supplement Facts: Serving Size: 1 capsule Servings per Container: 40 Amount per Serving %DV

Calories 2

Niacin 10 mg 50%

Vitamin B6 2 mg 100 %

Proprietary Blend: 289 mg Tillandsia usneoides, soy (bean), bovine liver PMG™ extract, betaine hydrochloride, calcium lactate, defatted wheat (germ), potassium bicarbonate, choline bitartrate, inositol, disodium phosphate, bovine adrenal Cytosol™ extract, oat flour, and ascorbic acid.

Other Ingredients: Gelatin, water, niacinamide, pyridoxine hydrochloride, colors, and calcium stearate.


Page 18


Betacol®

What Makes Betacol Unique

Product AttributesA distinctive product that contains choline

�i Choline is essential to metabolize fat cholesterol, proteins, and carbohydrates effectively†

Multiple nutrients from a variety of plant and animal sources

�i Extracts from bovine tissues provide nutrients and support to the corresponding tissues in humans


Contains Protomorphogen™ extracts

�i Standard Process uses a unique manufacturing method of deriving tissue cell determinants from animal glands and organs

�i Help provide cellular support and rehabilitation to the corresponding human tissues

�i Important antigenic properties of nucleoprotein-mineral determinants are the foundation of the product†

Manufacturing and Quality-Control ProcessesLow-temperature, high-vacuum drying technique







Studies on nutrients generally use large doses and these studies, some of which are cited below, are the basis for much of the information we provide you in this publication about whole food ingredients. See the supplement facts for Betacol®.

Anderson L.E. 1998. Mosby’s Medical, Nursing, & Allied Health Dictionary. 5th ed. St. Louis, MO: Mosby: 1366.

Arny N.P. Spanish Moss and Ball Moss. University of Florida: Cooperative Extension Service Institute of Food and Agricultural Sciences. Online. 21 May 2000.

Balch J.F., Balch Phyllis A. 1997. Prescription for Nutritional Healing. 2nd ed. Garden City Park, NY: Avery Publishing Group: 15-16.

Berdanier C.D. 1995. Advanced Nutrition Micronutrients. Boca Raton, FL: CRC Press: 94-105.

Coffee C.J. 1998. Metabolis. 1st ed. Madison, CT: Fence Creek Publishing: 69.

Costa M., Di Stasi L.C., Kirizawa M., et al. 1989. Screening in mice of some medicinal plants used for analgesic purposes in the state of Sao Paulo, part II. J Ethnopharmacol. 27(1-2): 25-33.

Di Padova C., Bosisio E., Cighetti G., et al. 1982. 3-Hydroxy-3-methylglutaric acid (HMGA) reduces dietary cholesterol induction of saturated bile in hamster. Life Sci. 30(22): 1907-1914.

Duke J. USDA – ARS – NGRL. Phytochemical and Ethnobotanical Database. Beltsville, MD: Beltsville Agricultural Research Center. Online. 22 May 2000.

Guyton A.C., Hall J.E. 1997. Human Physiology and Mechanisms of Disease. 6th ed. Philadelphia, PA: W.B. Saunders Company: 589.

Kirschmann J.D. 1979. Nutrition Almanac. Revised ed. New York, NY: McGraw-Hill Book Company: 25-27.

Labate M.E., Dam R. 1980. Effect of 3-hydroxy-3-methylglutaric acid on cholesterol metabolism in female Japanese quail. Poult Sci 59(2): 383-389.

Lupien P.J., Moorjani S., Brun D., et al. 1979. Effects of 3-hydroxy-3-methylglutaric acid on plasma and low-density lipoprotein cholesterol levels in familial hypercholesterolemia. J Clin Pharmacol. 19(2-3): 120-126.

Moorjani S., Lupien P.J. 1977. Effect in vitro of 3-hydroxy-3-methylglutaric acid on the synthesis of mevalonate and its precursors. Arch Int Physiol Biochim 85(1): 1-10.

Murakami T., Nagamura Y., Hirano K. 1998. The recovering effect of betaine on carbon tetrachloride-induced liver injury. J Nutr Sci Vitaminol 44(2): 249-255.

Pitchford P. 1993. Healing With Whole Foods. Revised ed. Berkeley, CA: North Atlantic Books: 122, 402-403.

Savoie L.L., Lupien P.J. 1975. Organ distribution of 3-hydroxy-3-methylglutaric acid, a potential anticholesterolemic agent. Can J Physiol Pharmacol 53(4): 638-643.

Savoie L.L., Lupien P.J. 1975. Preliminary toxicological investigations of 3-hydroxy-3-methylglutaric acid (HMG). I: Study of acute toxicity and of teratogenic activity in rats and mice. Arzneimittelforschung 25(8): 1284-1286.

Shils M.E., Young V.R. 1988. Modern Nutrition in Health and Disease. 7th ed. Philadelphia, PA: Lea and Febiger: 370-381.

Tillandsia usenoides. Ecology and Evolutionary Biology Conservatory. Online. 17 May 2000.

Tver D.F., Russell P. 1989. The Nutrition and Health Encyclopedia. 2nd ed. New York, NY: Van Nostrand Reinhold: 366-368, 445-446.

Van Niekerk J.L., Hendriks T., Gevers-Leuven, J.A., et al. 1984. The lipid-lowering effects of 3-hydroxy-3-methylglutaric acid and bile acid drainage in WHHL rabbits. Clin Sci 67(4): 439-444.

Wilson E.D., Fisher K.H., Fuqua M.E. 1965. Principles of Nutrition. 2nd ed. New York, NY: John Wiley & Sons, Inc: 290-294.

Witherup K.M., McLaughlin J.L., Judd R.L., et al. 1995. Identification of 3-hydroxy-3-methylglutaric acid (HMG) as a hypoglycemic principle of Spanish moss (Tillandsia usneoides ). J Nat Prod 58(8): 1285-1290.

Yousufzai S.Y., Siddiqi M. 1976. 3-Hydroxy-3-methylglutaric acid and triton-induced hyperlipidemia in rats. Experientia 32(9): 1178-1179.

Yousufzai S.Y., Siddiqi M. 1977. Serum and liver lipid responses to 3-hydroxy-3-methylglutaric acid in rats on different carbohydrate diets. Lipids 12(3): 262-266.

Page 19



Introduced in 1969




Calories 3


Niacin 2.8 mg 15%

Vitamin B6 0.8 mg 40%

Iron 2.7 mg 15%

Iodine 9.6 mcg 6%

Zinc 5.5 mg 35%

Copper 109 mcg 6%

Proprietary Blend: 582 mg Bovine liver PMG™ extract, Spanish black radish (root), bovine liver, calcium lactate, carrot (root), Tillandsia usneoides, beet (root), dried beet (leaf) juice, oat flour, betaine hydrochloride, magnesium citrate, choline bitartrate, soy (bean), potassium bicarbonate, bovine kidney, bovine prostate, bovine adrenal Cytosol™ extract, defatted wheat (germ), bovine liver fat extract, bovine orchic extract, ascorbic acid, flaxseed oil extract, and mixed tocopherols (soy).

Other Ingredients: Gelatin, zinc liver chelate, iron liver chelate, water, calcium stearate, niacinamide, copper liver chelate, colors, pyridoxine hydrochloride, arabic gum, starch, sucrose (beets), vitamin A palmitate, and prolamine iodine (zein).

Warning: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose, call a doctor or poison control center immediately.


Livaplex®

A Multi Food-Based Formula for the Liver

The liver is the body’s largest organ and performs more than 500 different

functions including the synthesis and utilization of carbohydrates, fats, and

proteins, the metabolism and excretion of toxins from the body, and the storage

of glycogen and several other nutrients. Livaplex is a special formula comprised

of several Standard Process ingredients designed to support the liver. This

product encourages healthy bile production and flow, the breakdown of fats,

liver-detoxification support, and the improvement of blood flow through the

liver. In addition, zinc, copper, and iron enhance the ability of the liver to

function normally.†

How Livaplex Keeps You Healthy

Provides several essential vitamins and minerals to support cellular health and metabolism of macronutrients

Vitamin A supports healthy cellular growth and helps the body maintain healthy

mucous membranes. At the cellular level, zinc supports DNA synthesis, cell

signaling, and supports protein and cell structure and function. Zinc also plays a

role in releasing hormones and supporting nerve impulse transmission. Copper

is involved in producing cellular energy, supporting the body’s natural

antioxidant functions, and aiding in iron metabolism. Iron is required for

oxygen transport and storage, energy metabolism, and many nutrient

interactions. The B vitamins are important building blocks for many metabolic

processes throughout the body. Vitamin B6 supports the metabolism of

carbohydrates through its facilitation of glycogen breakdown and niacin aids

in carbohydrate, protein, and lipid synthesis. B6 is also important for the

formation and function of red blood cells. Iodine is a trace mineral required for

thyroid-hormone synthesis.†

Supports the liver’s natural antioxidant functions

The liver is essential in eliminating toxins from the body. Cruciferous vegetables,

like Spanish black radish, contain phytochemicals that stimulate enzymatic

activity required to support liver detoxification.†

Supports digestive function

Betaine hydrochloride provides a supplemental source of hydrochloric acid

(HCl), an acid found in the gastric juice of the stomach, to help breakdown food

during digestion.†

Livaplex

®Page 20



Studies on nutrients generally use large doses and these studies, some of which are cited below, are the basis for much of the information we provide you in this publication about whole food ingredients. See the supplement facts for Livaplex®.

Bender, DA. Novel functions of vitamin B6. Proc Nutr Soc, 1994. 53(3):

p. 625-30.Cervantes-Laurean D, McElvaney NG, Moss J. Niacin. In: Shils M, Olson JA,

Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore: Williams & Wilkins; 1999:401-411.

Cousins, R. J. (2006). Zinc. In B. A. Bowman, Russell, R.M. (Ed.), Present Knowledge in Nutrition (9th ed., Vol. 1, pp. 445-457). Washington D.C.: ILSI Press.

Dakshinamurti, S, Dakshinamurti, K., Vitamin B6, in Handbook of Vitamins,

J. Zempleni, Rucker, R.B., McCormick, D.B., Suttie, J.W., Editor. 2007, CRC Press (Taylor & Francis Group): New York. p. 315-359.

Dunn, J. T. (1998). What’s happening to our iodine? J Clin Endocrinol Metab, 83(10), 3398-3400.

Hanlon, P. R., Webber, D. M., & Barnes, D. M. (2007). Aqueous extract from Spanish black radish (Raphanus sativus L. var. niger ) induces detoxification enzymes in the HepG2 human hepatoma cell line. J Agric Food Chem, 55(16), 6439-6446.

Harris, E. D. (1997). Copper. In B. L. O’Dell, Sunde, R.A. (Ed.), Handbook of nutritionally essential minerals (pp. 231-273). New York: Marcel Dekker, Inc.

Hetzel, B. S., Clugston, G.A. (1999). Iodine. In M. Shils, Olson, J.A., Shike, M., Ross, A.C. (Ed.), Modern Nutrition in Health and Disease (9th ed., pp. 253-264). Baltimore: Williams & Wilkins.

Jacob R, Swenseid M. Niacin. In: Ziegler EE, Filer LJ, eds. Present Knowledge in Nutrition. 7th ed. Washington D.C: ILSI Press; 1996:185-190.

Leklem, JE, Vitamin B6, in Handbook of Vitamins, L. Machlin, Editor. 1991,

Marcel Decker Inc: New York. p. 341-378.Lugasi, A., Blazovics, A., Hagymasi, K., Kocsis, I., & Kery, A. (2005).

Antioxidant effect of squeezed juice from black radish (Raphanus sativus L. var niger ) in alimentary hyperlipidaemia in rats. Phytother Res, 19(7), 587-591.

Mackey, AD, Davis, S.R., Gregory, J.F., Vitamin B6, in Modern Nutrition in

Health and Disease, M.E. Shils, Shike, M., Ross, A.C., Caballero, B., Cousins, R.J., Editor. 2006, Lippincott Williams & Wilkins: Philadelphia. p. 452-461.

McCormick, DB, Vitamin B6, in Present Knowledge in Nutrition, B.A.

Bowman, Russell, R.M., Editor. 2006, International Life Sciences Institute: Washington, D.C. p. 269-277.

Trumbo, P., Yates, A. A., Schlicker, S., & Poos, M. (2001). Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. J Am Diet Assoc, 101(3), 294-301.

Turnlund, J. R. (2006). Copper. In M. E. Shils, Shike, M., Ross, A.C., Caballero, B., Cousins, R.J. (Ed.), Modern Nutrition in Health and Disease (10th ed., pp. 289-299). Philadelphia: Lippincott Williams & Wilkins.

Uauy, R., Olivares, M., & Gonzalez, M. (1998). Essentiality of copper in humans. Am J Clin Nutr, 67(5 Suppl), 952S-959S.

Yip, R., Dallman, P.R. . (1996). Iron. In E. E. Ziegler, Filer, L.J. (Ed.), Present Knowledge in Nutrition (7th ed., pp. 277-292). Washington D.C.: ILSI Press.

Livaplex®

What Makes Livaplex Unique

Product AttributesMultiple nutrients and minerals from a variety of plant and animal sources

�i Extracts from bovine tissues provide cellular support and rehabilitation to the corresponding tissues in humans













�i The nutrients in Livaplex are processed to remain intact, complete nutritional compounds






Page 21

Passion Flower (Passiflora incarnata)

A Phytotherapist’s Passion“Philosopher and teacher Rudolf Steiner once said that, for every human illness, somewhere in the world there exists a plant which is the cure. I believe that there is a healing potential locked inside plants which is integral with their evolution, just as it is part of human evolution to learn to tap this wonderful gift of Nature.”

Associate Professor Kerry Bone MediHerb Co-Founder and Director of Research and Development

Quality is our Passion

* These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

LivCo®

LivCo® is a unique combination of Schisandra berries, concentrated Milk Thistle seed and Rosemary leaf. Schisandra berries have been used as a tonic in traditional Chinese medicine.1 Clinical trials suggest that to be effective Milk Thistle products should contain substantial levels of the important plant constituents: flavanolignans (collectively known as silymarin). The main flavanolignans are silybin, silychristin and silydianin. In these trials, concentrated Milk Thistle seed extract was used to support liver function.2*

How LivCo® Keeps You HealthyAids in the elimination of toxins and cleanses the liver

Milk Thistle has been used traditionally to aid in the elimination of toxins and cleanse the liver.3*

One of the things that helps Milk Thistle achieve this is due to what’s called enterohepatic circulation – the circulation that occurs between the intestine and the liver:3,4

after the flavanolignans in Milk Thistle are swallowed they are absorbed in the intestine

then excreted from the liver in the bile

and then they are reabsorbed in the intestine*

This means that the cells of the liver are in contact with the flavanolignans at a higher concentration than the level reached in the bloodstream.3,4 It is the contact at the cellular level of the liver that is important (see next).*

Protects liver tissue

Milk Thistle and Schisandra help protect liver tissue.1,5 Constituents of Schisandra known as lignans are likely to be important for this activity. Schisandra lignans may do this by enhancing the normal production of the antioxidant glutathione in the liver.1* (See over page – Antioxidant Protection.)

The flavanolignans of Milk Thistle help to ensure the integrity of the liver cell:

from the damaging effects of excessive free radicals5,6

by eliminating toxins5*

The flavanolignans of Milk Thistle also provide support by increasing the normal rate of synthesis of structural and functional proteins in liver cells. This helps the liver’s normal repair process.5 This increase in the normal synthesis of proteins is also one of the ways Schisandra helps protect liver tissue.1*

Supplement Facts

Serving size: 1 tablet Servings per container: 40, 120

Amount per Serving %DV Calories 2 Calcium 97 mg 9%

Schisandra fruit 6:1 extract 167 mg † from Schisandra chinensis fruit 1.0 g

Rosemary leaf 5:1 extract 100 mg † from Rosmarinus officinalis leaf 500 mg

Milk Thistle seed 70:1 extract 30 mg † from Silybum marianum seed 2.1 g Containing flavanolignans calc. as silybin 24 mg† Daily Value (DV) not established.

Other ingredients: Calcium acid phosphate, cellulose, maltodextrin, sodium starch glycollate, hypromellose, sorbitol and magnesium stearate.

Caution: Contraindicated in pregnancy. Contraindicated during lactation unless otherwise directed by a qualified health care professional. In anemia and cases where iron supplementation is required, do not take simultaneously with meals or iron supplements.

Product No Content

M1360 40 TabletsM1365 120 Tablets

LivCo®

M1360 / M1365

LivCo® M

1360 / M1365

Page 22

Quality is our PassionMediHerb products are developed by experts and leaders in the field of herbal therapy, using scientific evidence and hundreds of years of traditional knowledge.

Kerry Bone and over 20 health care professionals work within MediHerb while still managing their own clinical practices, plus we consult with an advisory board of health care professionals from around the world.

Our products are made using only the highest quality ingredients which are extensively tested for purity and potency. The MediHerb manufacturing plant operates to a strictly regulated pharmaceutical standard and is regularly audited by the Therapeutic Goods Administration (similar to the FDA), the same body that audits conventional pharmaceutical manufacturing facilities. The comprehensive regulations in Australia mean that you receive a safe and effective product that has been manufactured to pharmaceutical standards.

We know from our experience as health care professionals that the quality of a product you take makes a huge difference to the health outcome you experience. We dedicate ourselves to researching and making the best possible products to deliver health solutions that work.


Exclusive United States Distributor for MediHerb®

800-558-8740 www.standardprocess.com www.mediherb.com

Supports healthy liver function and digestive health

Rosemary leaf has been used traditionally to support healthy liver function and when the digestion requires support.7*

Provides antioxidant protection

Antioxidants help protect cells from the damaging effects of excessive free radicals. Free radicals are highly reactive substances created in the body that may affect cells.*

As well as protecting liver cells directly from the damaging effects of excessive free radicals, the flavanolignans of Milk Thistle may also provide broader antioxidant protection. They may do this by enhancing the normal production of some of the body’s antioxidants: superoxide dismutase and the glutathione system.1 This means that the flavanolignans may provide antioxidant protection for other body tissues as well as the liver.*

What Makes LivCo® UniqueLivCo® is unique in the professional herbal products industry because:

It is a liver support product that also provides antioxidant protection

The label states exactly how much each tablet contains of the important plant constituents (flavanolignans)

MediHerb tests the quantity of flavanolignans in Milk Thistle raw material

Unique Manufacture & Analytical Testing

Quality and safety ensured

Manufactured in Australia to the high standards of international pharmaceutical Good Manufacturing Practice

Raw materials and finished product are subjected to tough quality standards, including use of the latest and most relevant chemical analysis methods

References1 American Herbal Pharmacopoeia. Schisandra Berry – Schisandra chinensis: Analytical, Quality Control, and Therapeutic Monograph. American Herbal Pharmacopoeia, Santa Cruz, October 1999.2 Blumenthal M, Brinckmann J, Wollschlaeger B. The ABC Clinical Guide to Herbs. American Botanical Council, Austin, Texas, 2003.3 Rainone F. Am Fam Physician 2005; 72(7): 1285-12884 Faulstich H, Jahn W, Wieland T. Arzneim Forsch 1980; 30(3): 452-4545 Wellington K, Jarvis B. BioDrugs 2001; 15(7): 465-4896 Fraschini F, Demartini G, Esposti D. Clin Drug Invest 2002; 22(1): 51-657 ESCOP Monographs: The Scientific Foundation for Herbal Medicinal Products, 2nd Edn. ESCOP, European Scientific Cooperative on Phytotherapy, Exeter, 2003.

TM1360 05/11 © MediHerb® 2011. All rights reserved.

Page 23






Livton® Complex: Sustainable Liver ToningLivton® Complex is a unique combination of concentrated Milk Thistle seed extract, Globe Artichoke leaf, Dandelion root, Bupleurum root and Fringe Tree stem bark.*

The importance of the liver

A poorly functioning liver can have a wide-ranging effect on health eg sluggish digestion, constipation and digestive issues such as food intolerances. The liver is actively involved in the processing of what we ingest (take into our body). It also has to deal with any pollutants that we are exposed to. Alcohol, drug medications (eg painkillers, contraceptive pill) and a diet high in fat may put the liver under stress.1*

Closely associated with the liver is the gallbladder. The liver makes bile which is stored in the gallbladder. Bile plays an important role in fat digestion and absorption. It also helps with excretion of several important waste products from the blood.2*

What is a liver tonic?

A tonic is popularly thought of as something that makes you feel better, stronger or healthier. Natural clinicians use liver tonics to improve the tone, vigor and function of the liver.3 Improving the tone assists with the proper functioning of the liver tissues providing healthy responses when challenged.*

‘Spring tonics’ have been used for centuries and were often based upon liver herbs, to ensure that, after a winter of unhealthy food the liver would be strengthened. They helped in cleansing and refreshing the whole body. Because the modern diet is often less than ideal a ‘spring tonic’ is useful at any time of the year.4 Spring or liver tonics are recommended when the liver is under stress or not functioning well.3*

Why use herbal products from an environmentally-responsible manufacturer?

Herbal products are made from living plants. It is very important that as consumers and manufacturers we do all we can to ensure the continuation of these important plant species. Many species are threatened by destruction of their habitat and by unsustainable harvesting. One plant under threat is Fringe Tree (Chionanthus virginica) which is native to the United States. It is a large shrub or small tree that can grow to about 20 feet (6 m) and has showy, creamy white flowers. The bark of the root has been used therapeutically. But harvest of the root bark often results in death of the tree.*

One strategy to solve destructive harvesting is use a different part of the plant (eg leaves, twigs or stem) instead of the underground parts. But it is necessary to evaluate the differences and similarities between various parts of the same plant with respect to chemical composition. This is called a phytochemical comparison.5*

Supplement Facts

Serving size: 1 tablet Servings per container: 40, 120


Globe Artichoke leaf 4:1 extract 200 mg † from Cynara scolymus leaf 800 mg

Dandelion root 4:1 extract 100 mg † from Taraxacum officinale root 400 mg

Milk Thistle fruit 70:1 extract 100 mg † from Silybum marianum fruit 7.0 g Containing flavanolignans calculated as silybin 80 mg

Bupleurum root 4.5:1 extract 66.7 mg † from Bupleurum falcatum root 300 mg

Fringe Tree stem bark 5:1 extract 32 mg † from Chionanthus virginica stem bark 160 mg † Daily Value (DV) not established.

Other ingredients: Calcium acid phosphate, cellulose, hypromellose, magnesium stearate, silica and sodium starch glycollate.

Caution: Contraindicated in pregnancy. Contraindicated during lactation unless otherwise directed by a qualified health care professional. Contraindicated in closure of the gallbladder. In anemia and cases where iron supplementation is required, do not take simultaneously with meals or iron supplements. Use only with professional supervision in gallstones.

Product No ContentM1372 40 TabletsM1378 120 Tablets

Livton® ComplexM1372 / M1378

Livton® Com

plex M1372 / M

1378Page 24








MediHerb’s Research & Development team conducted a phytochemical comparison and found that there would be no loss of quality in switching from the root bark to the stem bark.6 In addition to this proactive example, MediHerb also has an active company policy regarding endangered and threatened medicinal plants.*

How Livton® Complex Keeps You HealthySupports healthy liver and gallbladder function

Dandelion root, Globe Artichoke, Milk Thistle seed and Bupleurum are traditional liver tonics.1,7 These herbs and Fringe Tree root bark have been used traditionally to support healthy liver and gallbladder function.1,3,8 A review of controlled clinical trials found that concentrated Milk Thistle seed extract may support liver function by helping ensure the integrity of the liver cell.9*

Encourage healthy digestive function and assimilation

Many herbs that are used to support liver function also encourage healthy digestive function.1 One of the main reasons is that all these herbs, except Bupleurum, assist the normal flow of bile from the liver and/or the gallbladder.1,3

An uncontrolled trial found that Globe Artichoke extract helped in those with mild digestive problems. Significant improvement was found after 2 months compared to before treatment for:10

inability to finish a regular meal

fullness after eating or slow digestion

What Makes MediHerb Livton® Complex UniqueLivton® Complex from MediHerb is unique in the professional herbal products industry because:

It states on the label exactly how much each tablet contains of the important plant constituents (flavanolignans)

Top quality and sustainably wildcrafted Dandelion root and Fringe Tree stem bark are used in the manufacture of this tablet

MediHerb tests the quantity of flavanolignans in Milk Thistle raw material, and ensures the flavanolignans are retained in the product throughout manufacture

MediHerb developed an accurate chemical analysis to assess the true level of flavanolignans

It contains Fringe Tree stem bark to help ensure continuity of supply and sustainable environmental practice




Unique extraction method using cold percolation for the Dandelion root, Bupleurum and Fringe Tree components of this tablet (this protects the delicate plant constituents, ensuring a full range of constituents)

Raw materials and finished product are subjected to tough quality standards, including use of the latest and most relevant chemical analysis methods

References1 Mills S, Bone K. Principles and Practice of Phytotherapy: Modern Herbal Medicine. Churchill Livingstone, Edinburgh, 2000.2 Guyton AC, Hall JE. Textbook of Medical Physiology, 10th Edn. W.B. Saunders, Philadelphia, 2000.3 Bone K. Clinical Guide to Blending Liquid Herbs. Herbal Formulations for the Individual Patient. Churchill Livingstone, USA, 2003. 5 Hoffmann D. The Complete Illustrated Holistic Herbal: A Safe and Practical Guide to Making and Using Herbal Remedies. Element Books, Rockport 1996.5 Zschocke S, Rabe T, Taylor JL et al. J Ethnopharmacol 2000; 71 (1-2): 281-292 5 Penman KG, Bone KM, Lehmann RP. Information on file. MediHerb Research Laboratories, 3/85 Brandl Street, Eight Mile Plains, Brisbane, Queensland, 4113, Australia, 2006. 7 World Health Organization. Medicinal Plants in the Republic of Korea. WHO Regional Office for the Western Pacific, Manilla, 1998. 8 Huang KC. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, 1993.9 Crocenzi FA, Roma MG. Curr Med Chem 2006; 13 (9): 1055-1074 9 Marakis G, Walker AF, Middleton RW et al. Phytomedicine 2002; 9 (8): 694-699


Page 25






Albizia Complex: Seasonal Stress ReliefAlbizia Complex is a unique combination of Albizia bark, Chinese Skullcap root and Feverfew leaf and stem to maintain normal upper respiratory tract and skin function.*

Albizia lebbek grows naturally in many parts of the world especially India, parts of the Himalayas and Burma. It is also cultivated and used for its timber and as a fodder plant.1 The bark has been used traditionally in India for centuries.2 Chinese Skullcap (botanical name Scutellaria baicalensis) has been used traditionally for centuries in China for a wide range of applications.3*

Feverfew was first used in ancient Greece and was much favored by the Renaissance herbalists. It is said that Feverfew received the botanical species name “parthenium” because the herb was used in saving the life of a man who fell from the Parthenon (the main temple on the Acropolis at Athens), when it was being built between 447 and 432 BC.4,5 Contemporary interest in Feverfew arose from the British public who used it in the late 1970s which was reported in newspapers.6 Studies conducted in the late 1990s revealed that top quality Feverfew extracts should contain substantial levels of the important plant constituent parthenolide.7*

How Albizia Complex Keeps You HealthyAssists in maintaining healthy breathing passages

Albizia has been used traditionally to support healthy nasal and bronchial passages to support free and clear breathing.2,8 Chinese Skullcap and Feverfew have been used traditionally to support healthy breathing.9,10*

Maintains normal upper respiratory tract and skin function

Chinese Skullcap is one of the most widely used Chinese herbs to support health in the upper respiratory tract.11,12 Albizia has been used traditionally to promote healthy skin.2,13*

Promotes a normal response to occasional seasonal stresses

Anecdotal reports in the 1980s indicate that Feverfew provided support for the upper respiratory tract during occasional seasonal stresses.14 By supporting healthy nasal and bronchial passages Albizia promotes a normal response to occasional seasonal stresses.*

Support a normal immune response

The results of a controlled clinical trial suggest that Albizia supports the body in producing a healthy profile of white blood cells when under stress.15*

Supplement Facts

Serving size: 1 tablet Servings per container: 40


Chinese Skullcap root 4:1 extract 200 mg † from Scutellaria baicalensis root 800 mg

Albizia bark 8:1 extract 100 mg † from Albizia lebbek bark 800 mg

Feverfew leaf & stem 5:1 extract 10 mg † from Tanacetum parthenium leaf & stem 50 mg† Daily Value (DV) not established.

Other ingredients: Calcium acid phosphate, cellulose, sodium starch glycollate, silica, hypromellose and magnesium stearate.

Caution: Contraindicated in individuals with known hypersensitivity to feverfew, parthenolide or other members of the daisy family. Not to be used during pregnancy and lactation unless otherwise directed by a qualified health care professional.

Product No ContentM1100 40 Tablets

Albizia ComplexM1100

Albizia Complex M

1100Page 26








What Makes Albizia Complex UniqueAlbizia Complex is unique in the professional herbal products industry because:

MediHerb tests raw materials for the quantity of:

parthenolide in Feverfew

MediHerb tests the quantity of parthenolide in Feverfew raw material

MediHerb conducts extensive testing to ensure the correct species of Scutellaria is used for Chinese Skullcap raw material




Raw materials and finished product are subjected to tough quality standards

Unique extraction method using cold percolation for the Albizia and Chinese Skullcap components of this tablet (this protects the delicate plant constituents, ensuring a full range of constituents)

References1 Prinsen JH. Trop Grasslands 1986; 20(2): 78−832 Tripathi RM, Sen PC, Das PK. J Ethnopharmacol 1979; 1(4): 385-3963 Bensky D, Clavey S, Stoger E. Chinese Herbal Medicine: Materia Medica, 3rd Edn. Eastland Press, Seattle, 2004.4 Barker J. The Medicinal Flora of Britain and Northwestern Europe: A Field Guide including plants commonly cultivated in the region. Winter Press, West Wickham, 2001.5 Le Strange R. A History of Herbal Plants. Angus & Robertson, London, 1977.6 Johnson ES. Feverfew (Overcoming common problems). London, Sheldon Press, 1984.7 McKenna DJ, Jones K, Hughes K et al. Botanical Medicines: The Desk Reference for Major Herbal Supplements, 2nd Edn. New York, Haworth Herbal Press, 2002.8 Tripathi RM, Biswas M, Das PK. J Res Indian Med Yoga Homoeopath 1977; 12(3): 37-419 Chang HM, But PP. Pharmacology and Applications of Chinese Materia Medica. World Scientific, Singapore, 1987.10 Grieve M. A Modern Herbal. First published 1931, reprinted Dover Publications, New York, 1971.11 Tang W, Eisenbrand G. Chinese Drugs of Plant Origin. Springer-Verlag, Berlin, 1992.12 Huang KC. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, 1993.13 Kapoor LD. CRC Handbook of Ayurvedic Medicinal Plants. CRC Press, Boca Raton, 1990.14 Britt J, Keen L. Feverfew. London, Century, 1987.15 Mukhopadhyay B, Nagaraju K, Sharma KR. J Res Edu Indian Med 1992; 11: 17-23


Page 27






Wormwood ComplexWormwood Complex is a unique combination of Wormwood herb, Black Walnut green hulls, Stemona root and Clove Bud essential oil.*

The importance of healthy intestinal flora

Not all bacteria are bad, in fact some bacteria are necessary for our survival and live in our intestine.1 The human gastrointestinal tract (mainly the lower end known as the colon or large bowel) is the natural habitat for a large and diverse population of microorganisms (called ‘flora’), mainly bacteria. The intestine of an adult contains up to 500 different species of bacteria. Scientists even think there may also be some species that have not yet been identified. In normal healthy circumstances the relationship is mutually beneficial for both partners: bacteria and host (you!).2*

Major functions of the intestinal flora include:2*

activities that result in the release of absorbable nutrients and substances that can be used for energy

protection of the host against invasion by alien flora

A healthy lower gastrointestinal tract contributes to a healthy intestinal environment and helps maintain proper gastrointestinal flora.*

How Wormwood Complex Keeps You HealthyCleanses the lower gastrointestinal tract

In Western civilization, Wormwood has been known since ancient times to cleanse the lower gastrointestinal tract (especially the large intestine). References to this plant appear in the writings of the ancient Egyptians, in early Syrian texts and in the Bible. Early European texts refer to it for this purpose and as a tonic. (It is said to have been brought to central Europe from the south by the early Christian monks.) Wormwood was published in an official list of therapeutic plants in Canada in 1868, and in the United States in 1830. Wormwood is now used traditionally around the world.3-7*

Stemona root and the green hull of Black Walnut fruit are used traditionally to help cleanse the lower gastrointestinal tract.8-10*

Supports healthy bowel function

Clove Bud essential oil has been used traditionally to support healthy bowel function. It may do this by helping produce regular peristaltic action. (Peristalsis is the process by which the contents of the gastrointestinal tract are pushed along (propelled). The muscular layers of the gastrointestinal tract do this by producing alternating contractions.) By making peristalsis more regular Clove Bud essential oil helps cleanse the bowel.11,12 The normal propulsive action also helps to maintain proper intestinal flora.2*

Supplement Facts



Stemona root 5:1 extract 200 mg † from Stemona sessilifolia root 1.0 g

Black Walnut green hulls 4:1 extract 25 mg † from Juglans nigra green hulls 100 mg

Wormwood herb 4:1 extract 25 mg † from Artemisia absinthium herb 100 mg

Clove bud (Syzygium aromaticum)essential oil 20 mg †

† Daily Value (DV) not established.

Other ingredients: Cellulose, silica, calcium acid phosphate, sodium starch glycollate, hypromellose and magnesium stearate.

Caution: Contraindicated in pregnancy and lactation.


Wormwood ComplexM1490

Worm

wood Com

plex M1490

Page 28








The intestinal flora also break down undigested matter in the feces, which produces gases. This can contribute to flatulence (or “wind”).1 Clove Bud essential oil has been used traditionally in this way to support healthy bowel function.10,12*

Wormwood has been used to support healthy bowel function by promoting efficient gastrointestinal elimination.4*

Stimulates digestion

Wormwood is traditionally used to stimulate digestion and promote the healthy flow of digestive enzymes. The ability of Wormwood to do this also supports healthy bowel function and a healthy intestinal environment.4,5,13*

What Makes Wormwood Complex UniqueWormwood Complex is unique in the professional herbal products industry because:

Top quality organically grown Wormwood and wildcrafted Black Walnut Hulls are used in the manufacture of this tablet

MediHerb tests the quantity of essential oil in Wormwood raw material

The formula was prepared after research in 2002 in conjunction with Australian university and government scientists, who investigated how the individual ingredients and formula might benefit intestinal health and help maintain proper intestinal flora in sheep





Unique extraction method using cold percolation for the Wormwood and Black Walnut Hulls components of this tablet (this protects the delicate plant constituents, ensuring a full range of constituents)

References1 Lazaroff M. The Complete Idiot’s Guide to Anatomy & Physiology. Alpha, Indianapolis, 2004.2 Guarner F. Digestion 2006; 73(Suppl 1): 5-123 Quinlan MB, Quinlan RJ, Nolan JM. J Ethnopharmacol 2002; 80(1): 75-834 Holmes P. The Energetics of Western Herbs: Treatment Strategies Integrating Western and Oriental Herbal Medicine, Volume 1, Revised 3rd Edn. Snow Lotus Press, Boulder, 1997.5 British Herbal Medicine Association’s Scientific Committee. British Herbal Pharmacopoeia. BHMA, Bournemouth, 1983.6 Erichsen-Brown C. Medicinal and Other Uses of North American Plants: A Historical Survey with Special Reference to the Eastern Indian Tribes. First published 1979, reprinted Dover Publications, New York, 1989.7 Boyle W. Official Herbs: Botanical Substances in the United States Pharmacopoeias 18201990. Buckeye Naturopathic Press, East Palestine, Ohio, 1991.8 World Health Organization. Medicinal Plants in Viet Nam. WHO Regional Office for the Western Pacific, Manilla, 1990.9 Pei SJ. J Ethnopharmacol 1985; 13(2): 121-13710 Felter HW, Lloyd JU. King’s American Dispensatory. 18th Edn, 3rd revision, Volume 1. First published 1905, reprinted Eclectic Medical Publications, Portland, 1983.11 Brunton TL. A Textbook of Pharmacology, Therapeutics, and Materia Medica. Adapted to the United States Pharmacopoeia by FH Williams. MacMillan and Co, London, 1885.12 Reynolds JEF (ed). Martindale: The Extra Pharmacopoeia, 26th Edn, The Pharmaceutical Press, London, 1973.13 Mills S. The Dictionary of Modern Herbalism. Thorsons, London, 1989.


Page 29


800-558-8740 | standardprocess.comGF This product contains less than 10 parts per million of gluten per serving size or less than 20 parts per million per the suggested use listed on each product label.


Zymex® IIContains Important Digestive Enzymes to Support Healthy Gastrointestinal Function

The word “enzyme” comes from Greek words that mean in yeast. Enzymes were

given this name when they were discovered while scientists were studying the

process of fermentation.

Enzymes help sustain life. Almost every chemical reaction that takes place in all

living cells of plants, animals, humans, and even of some bacteria begins by the

stimulation of some specific enzyme. Enzymes are catalysts, meaning they speed

up chemical reactions without changing themselves. They are the catalysts that

set off multitudes of specific activities and processes throughout the human

body. While hundreds of different enzymes have been discovered to date, each

enzyme performs a singular function. Although the enzymes are each

responsible for initiating a process that only that particular enzyme can

accomplish, they are related to one another enough to allow classification into

one of six categories. The proteolytic enzymes, for example, work to break down

proteins in the digestive tract.

How Zymex II Keeps You Healthy

Promotes healthy digestive function

As food is taken into the mouth and begins its journey down the alimentary

tract, it is met by a series of different enzymes. Each is responsible to initiate a

different chemical reaction in the digestive process and each is dependent upon a

certain acid or alkaline environment in order to perform its respective function.

The human body requires adequate amounts of these digestive enzymes in order

to break down ingested nutrients into substances suitable for absorption. The

proteolytic enzymes work in the digestive system and at the cellular level to help

digest proteins. Zymex II contains the proteolytic enzymes papain and

bromelain, which are historically isolated from papaya and pineapple,

respectively. In addition to proteolytic enzymes, Zymex II also contains amylase,

another hydrolytic enzyme that triggers the process of breaking down starch into

smaller carbohydrate molecules. Zymex II also contains lipase, an enzyme

produced by organs of the digestive system to stimulate the breakdown of lipids.†

Provides alkaline-based digestive support for the acid-sensitive individual

All enzymes, whether of the proteolytic variety or not, are extremely sensitive to

acid and alkaline surroundings. Zymex II contains bromelain and papain. Both

enjoy an optimum pH value of between 6 and 7.5 and remain stable in

temperatures of up to 60° and 80° C. These characteristics offer the acid-sensitive

individual digestive support without adding acid to the body.†

Zym

ex® II

Introduced in 1958

GF

Content: 40 capsules 150 capsules

Suggested Use: Two capsules between meals, twice daily, or as directed.

Supplement Facts: Serving Size: 2 capsules Servings per Container: 20 or 75

Amount per Serving %DV

Calories 4

Total Carbohydrate 1 g <1%*


Proprietary Blend: 884 mg Defatted almond (nut), fig (fruit), papain, bromelain, amylase, lipase, and cellulase.

Other Ingredients: Gelatin, water, maltodextrin, and colors.


Page 30


Zymex® IIWhat Makes Zymex II Unique

Product AttributesContains proteolytic enzymes and synergists

�i Papain and bromelain supported by other enzymes like amylase and lipase, as well as the whole food synergists almond and fig

Does not contain pancreatin or betaine hydrochloride

�i Developed for the acid-sensitive individual†

Manufacturing and Quality-Control ProcessesNot disassociated into isolated components

�i The nutrients in Zymex II are processed to remain intact, complete nutritional compounds






Studies on nutrients generally use large doses and these studies, some of which are cited below, are the basis for much of the information we provide you in this publication about whole food ingredients. See the supplement facts for Zymex® II.

Anderson L.E. 1998. Mosby’s Medical, Nursing, & Allied Health Dictionary. 5th ed. St. Louis, MO: Mosby: 80, 946.

Balch J.F., Balch P.A. 1997. Prescription for Nutritional Healing. 2nd ed. Garden City Park, NY: Avery Publishing Group: 87, 108-109, 341, 354, 361.

Canaan S., et al. 1999. Gastric lipase: crystal structure and activity. Biochemical Biophysical Acta 1441(2-3): 197-204.

Clemetson C.A., et al. 1978. Estrogens in food: the almond mystery. International Journal of Gynaecology and Obstetrics 15(6): 515-521.

Han W.G., et al. 1999. QM/MM study of the active site of free papain and of the NMA-papain complex. Journal of Biomolecular Structural Dynamics 16(5): 1019-1032.

Henderson T.R., et al. 1998. Effect of pasteurization on long chain polyunsaturated fatty acid levels and enzyme activities of human milk. Journal of Pediatrics 132(5): 876-878.

Luz S., et al. 1997. Current concepts of digestion and absorption of carbohydrates. Arq Gasterenterol 34(3): 175-185.

Monograph: Bromelain. Alternative Medicine Review. 1998. 3(4): 302-305.

Monter B., et al. 1991. Kinetically controlled synthesis of dipeptides using ficin as biocatalyst. Biotechnological Applications in Biochemistry 14(2): 183-191.

Ohmori T., Yang R.Y. 1996. Self-sustained pH oscillations in immobilized proteolytic enzyme systems. Biophysical Chemistry 59(1-2): 87-94.

Pitchford P. 1993. Healing with Whole Foods, Oriental Traditions and Modern Nutrition. Revised ed. Berkeley, CA: North Atlantic Books: 127, 130, 148, 178, 492, 578, 581-582, 618.

Spiller G.A., et al. 1998. Nuts and plasma lipids: an almond-based diet lowers LDL-C while preserving HDL-C. Journal of the American College of Nutrition 17(3): 285-290.


Page 31




Introduced in 1963

GF

Content: 40 capsules 150 capsules


Supplement Facts: Serving Size: 1 capsule Servings per Container: 40 or 150 Amount per Serving %DV

Calories 2

Cholesterol 5 mg 2%

Proprietary Blend: 410 mg Fig (fruit), defatted almonds, pancreatin (3x), fatty acids, bromelain, lipase, cellulase, papain, and amylase.

Other Ingredients: Gelatin, lactose (milk), maltodextrin, water, colors, and calcium stearate.

Each capsule supplies approximately: 175 mg pancreatin (3x).


Multizyme®

Contains Digestive Enzymes to Support the Proper Breakdown and Absorption of Proteins, Carbohydrates, Sugars, and Fats

Enzymes are protein molecules that catalyze, or jump-start, nearly all

biochemical activity in the body. Enzymes are needed to digest food, produce

energy inside cells, activate the brain, help the body maintain cells, tissues, and

organs, plus support other functions of the body. Without enzymes, many

chemical reactions in the body would not be supported. Enzymes have unique

chemical structures and perform specific tasks, so one enzyme cannot substitute

for another. Enzymes fall into two main categories: digestive or metabolic. The

digestive enzymes work in the intestinal tract to break down the foods we eat, so

nutrients can be absorbed into the blood for use in the body. Digestive enzymes

are divided into amylases, proteases, and lipases. Amylases are found in saliva

and pancreatic juice. The sole responsibility of amylases is to break down

carbohydrates and sugars for absorption. Proteases are found in pancreatic,

stomach, and intestinal juices and are responsible for digesting proteins. Lipases

break down fats and are found in the stomach and pancreatic juices, as well as in

foods that contain fat. The body procures some enzymes from food. Raw foods

from both plant and animal sources provide the greatest percentage of enzymes,

since heat and cooking can destroy these sensitive molecules. Digestive enzymes

enable our bodies to obtain optimal nutritional benefit from the foods we eat.

Multizyme is an enzyme supplement that can aid in digestion.†

How Multizyme Keeps You Healthy

Supports the proper and efficient breakdown of foods and absorption of nutrientsWhile the solid foods and liquids we eat every day contain the vital nutrients our bodies need to operate normally, they are of no use unless they can be absorbed into the bloodstream. Digestive enzymes ensure that proteins, carbohydrates, sugars, and fats are chemically transformed into molecules that can be absorbed and used by the tissues of the body.

Figs and almonds contribute fatty acids, fiber, and vitamins and minerals that

encourage healthy digestion. The proteolytic enzyme pancreatin is a concentrate

of important pancreatic enzymes needed to break down dietary proteins, fats,

and starch into amino acids, glycerol and fatty acids, and simple sugars,

respectfully. Bromelain and papain are proteolytic enzymes from plants that help

the body digest proteins. Lipases trigger lipid breakdown while cellulases work

together to hydrolyze cellulose. Amylase sparks the hydrolysis of starch into

smaller mono- and polysaccharide carbohydrate molecules. Together, enzymes

in Multizyme work synergistically to encourage the efficient breakdown of food

in the digestive tract and enhance the absorption of vital nutrients.†

Mu

ltizyme

®Page 32



Studies on nutrients generally use large doses and these studies, some of which are cited below, are the basis for much of the information we provide you in this publication about whole food ingredients. See the supplement facts for Multizyme®.

Anderson L.E. 1998. Mosby’s Medical, Nursing, & Allied Health Dictionary. 5th ed. St. Louis, MO: Mosby: 80, 290, 619, 946, 1193, 1196.

Balch J.F., Balch P.A. Prescription for Nutritional Healing. 2nd ed. Garden City Park, NY: Avery Publishing Group: 47-48.

Boyer P.D. 1971. The Enzymes. 3rd ed. New York, NY: Academic Press: 485-546.

Dressler D., Potter H. 1991. Discovering Enzymes. New York, NY: Scientific American Library: 7-13.

Fisher M., LaChance P. 1999. Nutrition & Health Aspects of Almonds. Modesto, CA: Almond Board of California: 1-7.

Fraser G.E. 1999. Nut consumption, lipids, and risk of a coronary event. Clinical Cardiology 22(7): III11-III15.

Fruton J.S. 1999. Proteins, Enzymes, Genes the Interplay of Chemistry and Biology. New Haven, CT: Yale University Press: 223.

Goodwin T.W., Harris J.I., Hartley B.S. 1964. Structure and Activity of Enzymes. New York, NY: Academic Press.

Harrow B. 1950. One Family: Vitamins, Enzymes, Hormones. Minneapolis, MN: Burgess Publishing Company: 55-74.

Laidler K.J. 1954. Introduction to the Chemistry of Enzymes. New York, NY: McGraw-Hill Book Company, Inc: 1-2, 34-59.

Masson M. 1995. Fortschr Med 113(19): 303-306.Mazda T., et al. 1995. Use of standardized protease enzymes for antibody

screening of blood donor samples with the microplate system AutoAnalyzer. Transfusion Medicine 5(1): 43-50.

Metzig C., et al. 1999. Bromelain proteases reduce human platelet aggregations in vitro, adhesion to bovine endothelial cells and thrombus formation in rat vessels in vivo. In Vivo 13(1): 7-12.

Mihalyi E. 1972. Application of Proteolytic Enzymes to Protein Structure Studies. Cleveland, OH: CRC Press: 39-101.

Monograph: Bromelain. 1998. Alternative Medicine Review 3(4): 302-305.

Nuts Are Back! Mediterranean Diet Pyramid Says Eat Nuts Daily. 1998-2000. Sacramento, CA: Blue Diamond Growers: 1-4.

Palmer T. 1995. Understanding Enzymes. 4th ed. New York, NY: Prentice Hall/Ellis Horwood: 3-11, 74.

Pitchford P. 1993. Healing With Whole Foods. Revised ed. Berkeley, CA: North Atlantic Books: 50, 68, 78, 163, 227, 275, 578.

Price N.C., Stevens L. 1989. Fundamentals of Enzymology. 2nd ed. Oxford, NY: Oxford University Press: 473.

Samuelson A. Phytochemicals In Nuts: New Science With Great Promise. California Almond Board: Ketchum Public Relations.

Spiller G.A., Bruce B. 1997. Nuts and healthy diets. Vegetarian Nutrition 1(1): 12-16.

Starley I.F., et al. 1999. The treatment of paediatric burns using topical papaya. Burns 25(7): 636-639.

Subbarayan P.R., et al. 1997. Report on a patient with paroxysmal cold hemoglobinuria. International Journal of Hematology 65(2): 165-167.

Turk B., et al. 1997. Structural and functional aspects of papain-like cysteine proteinases and their protein inhibitors. Biological Chemistry 378(3-4): 141-150.

Whitaker J.R. 1994. Principles of Enzymology for the Food Sciences. 2nd ed. New York, NY: Marcel Dekker, Inc: 469-493, 499-511.

Multizyme®

What Makes Multizyme Unique


�i Combines multiple digestive enzymes with fatty acids and fiber to stimulate the proper digestion of macronutrients and support gastrointestinal health†






Page 33




Collinsonia RootCombines Strong Antioxidant Properties With a Natural Affinity to Support Vascular Tissue

Different parts of the collinsonia plant can be taken internally or applied

topically, depending on the indication for use. The Chinese have used different

parts of Collinsonia canadensis for centuries to help support the liver, lungs,

colon, and fibrous tissue surrounding the heart. The beneficial chemical

elements found in collinsonia root include saponins, resin, tannin, organic acid,

and mucilage.†

How Collinsonia Root Keeps You Healthy

Supports healthy blood vessel tone and fluid levels

Collinsonia encourages vascular tissue contraction and moves blood or body

fluids through the vessels to maintain healthy fluid levels.†

Promotes digestive efficiency

Collinsonia has historically been used to help support gastrointestinal health.†

Helps maintain heart and lung health

Similar to its ability to help move blood and body fluids, collinsonia also helps

maintain heart and lung health. Collinsonia works to keep mucus membranes

healthy, which in turn helps the lungs work more efficiently.†

Helps maintain a healthy urinary system

Collinsonia naturally helps the body eliminate excess fluid and byproducts from

tissues throughout the body. These cleansing characteristics give collinsonia the

ability to help maintain a healthy environment in the urinary system.†

Collin

sonia R

oot

Introduced in 1955 GF


Suggested Use: Two capsules with a full glass of water twice a day, between meals, or as directed.

Supplement Facts: Serving Size: 2 capsules Servings per Container: 75 Amount per Serving %DV

Calories 3

Collinsonia (Root) 600 mg

Ingredients: See Supplement Facts.

Other Ingredients: Gelatin, water, calcium stearate, and colors.


Page 34


Collinsonia RootWhat Makes Collinsonia Root Unique

Product AttributesEach capsule supplies 300 mg of collinsonia-root powder

�i All the benefits of whole foods in a convenient form


�i The nutrients in Collinsonia Root are processed to remain intact, complete nutritional compounds







Studies on nutrients generally use large doses and these studies, some of which are cited below, are the basis for much of the information we provide you in this publication about whole food ingredients. See the supplement facts for Collinsonia Root.

Anderson L.E. 1998. Mosby’s Medical, Nursing, & Allied Health Dictionary. 5th ed. St. Louis, MO: Mosby: 59, 107, 139, 246, 1056, 1406, 1448.

Duke J.A., Foster S. 1990. Medical Plants (Eastern/Central), Peterson Field Guides. Boston, MA: Houghton Mifflin: 112-113.

Frawley D., Lad V. 1992. The Yoga of Herbs. 3rd ed. Twin Lakes, WI: Lotus Press: 215.

Hoffmann D.L. 1995. The New Holistic Herbal. Britain: Barnes & Noble (special edition by arrangement with Elemental Book Limited): 235.

Lewis W.H., Elvin-Lewis P.F. 1977. Medical Botany: Plants affecting Man’s Health. New York, NY: John Wiley & Sons: 312-313.

Stevens J.F., et al. 1999. A novel 2-hydroxyflavone from Collinsonia canadensis. J Nat Prod 62(2): 392-394.

Tierra M. 1988. Planetary Herbology. Boston, MA: Lotus Press: 283-284.Winston D. 1999. Herbal Therapeutics: Specific Indications For Herbs &

Herbal Formulas. 6th ed. Herbal Therapeutics Research Library: 37.

Page 35




Introduced in 1998 GF


Suggested Use: One capsule per day, or as directed.


Calories 3

Vitamin K 4 mcg 4%

Potassium 10 mg <1%

Kale 300 mg

Brussels sprouts 300 mg


Other Ingredients: Gelatin, water, calcium stearate, and colors.


Cruciferous Complete™

Contains Organically Grown, Minimally Processed Kale and Brussels Sprouts

Research demonstrates that cruciferous vegetables, such as kale and Brussels

sprouts, contain important phytonutrients that help protect against free radicals,

the highly unstable molecules that can damage cells and genetic material.

Cruciferous vegetables are nutrient-dense foods packed with many essential

vitamins, minerals, and antioxidants. Cruciferous vegetables also contain

important health-promoting nutrients like carotenoids and other phytochemicals

that stimulate enzymatic activity to support liver detoxification.†

How Cruciferous Complete Keeps You Healthy

Furnishes many nutrients to support health

Cruciferous Complete contains kale and Brussels sprouts, which contain a broad

spectrum of micronutrients, including vitamins B6, C, and K; dietary fiber;

copper; calcium; and potassium. A class of plant pigments, called carotenoids, is

also found in crucifers. These pigments, including beta carotene and lutein, serve

important roles within the body. Beta carotene is a precursor to vitamin A, while

lutein is found in abundance in the retina of the eye. Carotenoids and other

phytochemicals also have antioxidant properties and can protect cells from

damage of excess reactive oxygen species.†

Provides antioxidant support

The health-promoting phytochemicals in cruciferous vegetables protect cells

against free-radical damage and have been shown in the laboratory to alter the

metabolic pathways responsible for the metabolism of hormones in cultured

cells and in mice.†

Induces liver detoxification enzymes

Cruciferous vegetables contain highly active phytochemicals called

glucosinolates. In laboratory cell cultures and mice, products left from the

breakdown of glucosinolates stimulate the phase I and phase II liver enzymes,

two biochemical pathways in the liver involved in converting toxins into

harmless substances that can easily be excreted from the body.†

Cru

ciferous C

omplete

™Page 36


Cruciferous Complete™

What Makes Cruciferous Complete Unique


�i Each capsule supplies 300 mg each of organically grown kale and Brussels sprouts




Unique ProcessingUpon harvesting, nutrient-rich plants are immediately washed and promptly processed





�i The nutrients in Cruciferous Complete are processed to remain intact, complete nutritional compounds







Studies on nutrients generally use large doses and these studies, some of which are cited below, are the basis for much of the information we provide you in this publication about whole food ingredients. See the supplement facts for Cruciferous Complete™.

Auborn, K. J., Fan, S., Rosen, E. M., Goodwin, L., Chandraskaren, A., Williams, D. E., et al. (2003). Indole-3-carbinol is a negative regulator of estrogen. J Nutr, 133(7 Suppl), 2470S-2475S.

Hecht, S. S. (1999). Chemoprevention of Cancer by Isothiocyanates, Modifiers of Carcinogen Metabolism. J. Nutr., 129(3), 768.

Hecht, S. S. (2000). Inhibition of carcinogenesis by isothiocyanates. Drug Metab Rev, 32(3-4), 395-411.

Holick, C. N., Michaud, D. S., Stolzenberg-Solomon, R., Mayne, S. T., Pietinen, P., Taylor, P. R., et al. (2002). Dietary carotenoids, serum beta-carotene, and retinol and risk of lung cancer in the alpha-tocopherol, beta-carotene cohort study. Am J Epidemiol, 156(6), 536-547.

Holst, B., Williamson, G. (2004). A critical review of the bioavailability of glucosinolates and related compounds. Nat Prod Rep, 21(3), 425-447.

Institute of Medicine Food and Nutrition Board. (2000). Beta-carotene and other carotenoids. In Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids (pp. 325-400). Washington D.C.: National Academy Press.

International Agency for Research on Cancer. (1998). IARC Handbooks of Cancer Prevention: Carotenoids. Lyon: International Agency for Research on Cancer.

Johnston, N. (2004). Sulforaphane halts breast cancer cell growth. Drug Discovery Today, 9(21), 908.

Keck, A.-S., & Finley, J. W. (2004). Cruciferous Vegetables: Cancer Protective Mechanisms of Glucosinolate Hydrolysis Products and Selenium. Integr Cancer Ther, 3(1), 5-12.

Krinsky, N. I., Landrum, J. T., & Bone, R. A. (2003). Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye. Annu Rev Nutr, 23, 171-201.

Kristal, A., Lampe JW. (2002). Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer, 42(1), 1-9.

Liu, R. H. (2004). Potential Synergy of Phytochemicals in Cancer Prevention: Mechanism of Action. J. Nutr., 134(12), 3479S-3485.

Mares-Perlman, J. A., Millen, A. E., Ficek, T. L., & Hankinson, S. E. (2002). The body of evidence to support a protective role for lutein and zeaxanthin in delaying chronic disease. Overview. J Nutr, 132(3), 518S-524S.

Munday, R., & Munday, C. M. (2004). Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl isothiocyanate with sulforaphane and related compounds. J Agric Food Chem, 52(7), 1867-1871.

Olson, J. A. (1999). Carotenoids and human health. Arch Latinoam Nutr, 49(3 Suppl 1), 7S-11S.

Rao, A. V., & Rao, L. G. (2007). Carotenoids and human health. Pharmacol Res, 55(3), 207-216.

Telang, N. T., Katdare, M., Bradlow, H. L., Osborne, M. P., & Fishman, J. (1997). Inhibition of proliferation and modulation of estradiol metabolism: novel mechanisms for breast cancer prevention by the phytochemical indole-3-carbinol. Proc Soc Exp Biol Med, 216(2), 246-252.

van Poppel, G., Verhoeven, D. T., Verhagen, H., & Goldbohm, R. A. (1999). Brassica vegetables and cancer prevention. Epidemiology and mechanisms. Adv Exp Med Biol, 472, 159-168.

Verhoeven, D. T., Goldbohm, R. A., van Poppel, G., Verhagen, H., van den Brandt, P. A. (1996). Epidemiological studies on Brassica vegetables and cancer risk. Cancer Epidemiol Biomarkers Prev, 5(9), 733-748.

Walters, D. G., Young, P. J., Agus, C., Knize, M. G., Boobis, A. R., Gooderham, N. J., et al. (2004). Cruciferous vegetable consumption alters the metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in humans. Carcinogenesis, 25(9), 1659-1669.

Young, A. J., & Lowe, G. M. (2001). Antioxidant and prooxidant properties of carotenoids. Arch Biochem Biophys, 385(1), 20-27.

Zhang, Y. (2004). Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action. Mutat Res, 555(1-2), 173-190.

Ziegler, R. G. (1989). A review of epidemiologic evidence that carotenoids reduce the risk of cancer. J Nutr, 119(1), 116-122.

Page 37

Passion Flower �8I[[QàWZI�QVKIZVI\I�

A Phytotherapist’s Passiont8PQTW[WXPMZ�IVL�\MIKPMZ�:]LWTN�;\MQVMZ�WVKM�[IQL�\PI\��NWZ�M^MZa�P]UIV�QTTVM[[��[WUM_PMZM�QV�\PM�_WZTL�\PMZM�M`Q[\[�I�XTIV\�_PQKP�Q[�\PM�K]ZM��1�JMTQM^M�\PI\�\PMZM�Q[�I�PMITQVO�XW\MV\QIT�TWKSML�QV[QLM�XTIV\[�_PQKP�Q[�QV\MOZIT�_Q\P�\PMQZ�M^WT]\QWV��R][\�I[�Q\�Q[�XIZ\�WN�P]UIV�M^WT]\QWV�\W�TMIZV�\W�\IX�\PQ[�_WVLMZN]T�OQN\�WN�6I\]ZM�u




Garlic Forte: Active ReleaseGarlic clove (or bulb) has been used therapeutically for over 3500 years. *U�JT�BMTP�VTFE�JO�NPTU�DVMUVSFT�PG�UIF�XPSME�UP�QSPWJEF�B�EJTUJODUJWF�èBWPS�to food.1,2 There is much written about the history of garlic use. Garlic was fed to laborers in ancient Egypt, perhaps to help them maintain their strength. During some of the earliest Olympic Games (in ancient Greece) athletes were fed garlic before they competed. During the Middle Ages garlic became available in Europe after the Roman legions moved north. Garlic was grown in monasteries during Medieval times. Garlic grew freely in the woods of North America and native Americans used garlic in their tea.3*

Garlic constituents: the all important organic sulfur compounds

Garlic is a complex herb, and contains hundreds of constituents. Many of these constituents give garlic its characteristic smell; they are sulfur-containing organic compounds. By 1998 it became apparent from clinical TUVEJFT�UIBU�GPS�PQUJNBM�FGçDBDZ �HBSMJD�QSPEVDUT�TIPVME�DPOUBJO�TVCTUBOUJBM�levels of the important sulfur compound alliin.4 There are many types of garlic products available on the market: fresh (raw) garlic, dried garlic (garlic powder), garlic oils and aged garlic extract. The range of constituents in these products varies, as does the amount of important constituents. Only raw garlic and very carefully dried garlic powder contain alliin, aged garlic extract does not.5*

When a garlic clove is crushed, or when dried garlic powder gets wet the odorless alliin is broken down by the enzyme alliinase. Alliin is then converted into allicin and other strong smelling sulfur compounds.4*

Garlic products: is the allicin available for absorption in the body?

Because stomach acid can degrade alliinase, quality garlic powder products should be enterically coated. This type of coating protects the tablet (and the enzyme, alliinase) from being broken down in the stomach. (If alliinase became degraded, allicin would not be produced from alliin.) When enterically coated, the tablet survives intact and enters the intestine. Providing the tablet has a properly formulated coating, it is able to break down in the non-acidic environment of the small intestine and the enzymatic reaction can occur. Allicin is produced and can then be absorbed in the large intestine. If the enteric coating cannot break down in the intestine, allicin will not be produced, and then cannot be absorbed.2 It is possible in the laboratory to measure the amount of allicin released from garlic tablets. This is called “under simulated gastrointestinal conditions.”6*

Supplement Facts



Garlic Bulb 12:1 extract 300 mg † from Allium sativum bulb 3.6 gContaining alliin 12 mg† Daily Value (DV) not established.

Other ingredients: Calcium hydrogen phosphate, cellulose, sodium starch glycollate, garlic bulb powder, enteric coating, magnesium stearate, silica and d-alpha-tocopherol.

Caution: Contraindicated in known cases of allergy to Garlic. Contraindicated in lactation. Not to be used during pregnancy unless otherwise directed by a RVBMJçFE�IFBMUI�DBSF�QSPGFTTJPOBM�

Product No ContentM1285 40 Enteric Coated Tablets

Garlic ForteM1285

Alliin: The compound found in raw and carefully dried garlic powder

Allicin: The active ingredient formed from alliin in the small intestine

Alliinase: The delicate enzyme required for the conversion of alliin to allicin

Garlic Forte M1285

Page 38


Why use top quality herbal products from a reliable manufacturer?

$POTVNFST�OFFE�UP�CF�DPOçEFOU�PG�UIF�JOUFHSJUZ�PG�UIF�IFSCBM�NBOVGBDUVSFS�UP�FOTVSF�UIBU�UIF�product contains the stated amount of important constituents. Labels of garlic products that report allicin content are probably reporting potential allicin not actual allicin. So the amount of allicin delivered to the body is not guaranteed.2 The amount of alliin converted to allicin can be as little as 10%. Conversion depends on the amount and activity of the alliinase.7*

The activity of alliinase may be substantially decreased, for example, by:8*

processing garlic bulb into a powder (eg with the use of heat)

the presence of other compounds in the tablet

incorrect disintegration of the tablet (because of its coating)

But there are more quality issues that consumers need to be concerned with, such as:*

How much alliin is in the raw material?

Is the enzyme (alliinase) present and able to do the conversion (alliin � allicin)?

Will the alliinase survive the acidic environment of the stomach (is the tablet enteric-coated?)

If enteric-coated, will the tablet disintegrate correctly in the intestine liberating the (protected) alliinase, allowing the conversion to occur and providing the allicin for absorption?

How Garlic Forte Keeps You HealthySupports cardiovascular system health

Garlic has been used traditionally to support cardiovascular health.3 Many clinical trials have been DPOEVDUFE�UP�JOWFTUJHBUF�UIFTF�FGGFDUT�PG�HBSMJD �CVU�UIF�SFTVMUT�BSF�DPOèJDUJOH 6 probably because of the unknown quality of the garlic products that were evaluated.1 But more importantly, because the allicin release from the tablets was not known.6*

An analysis of the results of 29 placebo-controlled trials to November 2007 found that garlic helps maintain normal cholesterol and triglyceride levels already within a normal range.9 One of these trials, which found positive results, reported the amount of allicin released from the tablet under simulated gastrointestinal conditions: 9.6 mg of allicin in the daily dose.5,10 Several trials using top RVBMJUZ�HBSMJD�UBCMFUT�QVCMJTIFE�TJODF�UIJT�EBUF�IBWF�DPOçSNFE�UIJT�BDUJWJUZ�11-13*

Alliin

Alliinase

Allicin

Reaction of Garlic powder withalliinase to form allicin by HPLC

Peak due to alliinhas disappeareddue to conversionto allicin

The top diagram illustrates the chemical conversion of alliin to allicin by alliinase.

The bottom diagram illustrates how the alliin to allicin conversion can CF�WFSJçFE�VTJOH�)JHI�Performance Liquid $ISPNBUPHSBQIZ�)1-$��)1-$�JT�B�TPQIJTUJDBUFE�testing method used SPVUJOFMZ�CZ�.FEJ)FSC�

Page 39


The brand of garlic tablet used in most of the clinical trials from 1994 to 2000 was tested by researchers from Utah in 2001. They found that the allicin release under simulated gastrointestinal conditions varied from 14% to 18% of the allicin potential. (Allicin potential is the amount that should be released based on the alliin content.)5,6 These results strongly suggest that to be effective, garlic tablets need to be standardized for alliin content and release allicin under simulated gastrointestinal conditions.*

Garlic also supports the cardiovascular system in other ways.*

Double-blind, placebo-controlled trials have shown that allicin-releasing garlic powder helps the blood to have healthy platelet function.14,15 Healthy platelet function is � � OFDFTTBSZ�GPS�B�IFBMUIZ�CMPPE�èPX�BOE�UIF�DPOUJOVJOH�IFBMUI�PG�UIF�CMPPE�WFTTFMT��

Double-blind, placebo-controlled trials conducted to the end of June 2008 found that standardized garlic powder tablets helped maintain normal blood pressure already within a normal range.16*

4UBOEBSEJ[FE�HBSMJD�QPXEFS�UBCMFU�XBT�BMTP�GPVOE�UP�JNQSPWF�CMPPE�èPX�UP�UIF�TLJO�BOE�tissues in healthy volunteers.14,17*

Another well-designed trial and further research has found that garlic helps keep the walls of the blood vessels healthy in a similar way to HDL-cholesterol. (HDL-cholesterol is the ‘good cholesterol’ in your body.)18,19*

Promotes health in the gastrointestinal system

Population studies that involved people in Italy and Switzerland (1991–2004) found that garlic in the diet was associated with a healthy gastrointestinal tract (mouth, pharynx, esophagus, larynx and large bowel). The analysis compared the health of people eating high amounts of garlic with those eating none or a low amount.20 Scientists think that the sulfur compounds in HBSMJD�BSF�JNQPSUBOU�GPS�UIFTF�CFOFçDJBM�FGGFDUT�21*

During World War I garlic was used to help ensure intestinal health in soldiers stationed in the Balkans.22 In 1941, an American clinician conducted an unblinded, controlled trial and GPVOE�HBSMJD�IFMQFE�NBJOUBJO�QSPQFS�HBTUSPJOUFTUJOBM�èPSB�JO�UIPTF�XJUI�B�IJTUPSZ�PG�QPPS�gastrointestinal function.23 In a 1991 uncontrolled trial in Egypt, it was found that garlic promoted intestinal health and normal stools in children.24*

Enhances immune system response and promotes healthy lung function

%VSJOH�UIF�çSTU�DFOUVSZ �UIF�PGçDJBM�"SNZ�QIZTJDJBO�%JPTDPSJEFT�TQFDJçFE�UIBU�HBSMJD�CF�UBLFO�by Roman soldiers to support a healthy response in the lungs.25 More recently, garlic has been used traditionally to support healthy lung function. It may do this by stimulating the mucous membranes and promoting healthy secretions in the lung.26-28*

In the 1980s Russian newspapers advised the chewing of raw garlic to enhance normal immune response in the upper respiratory tract.26 In World War II, the Soviet army also used garlic to enhance normal immune response.29 Volunteers taking a garlic tablet were more likely to stay healthy during the winter months and have healthy respiratory tract function than those taking placebo. This randomized, double-blind study was conducted in England and published in 2001.30*

3URYLGHV�DQWLR[LGDQW�VXSSRUW�DQG�KHOSV�QRUPDO�PHWDEROLF�GHWR[L°FDWLRQ

Antioxidants help protect cells from the damaging effects of excessive free radicals. Free radicals are highly reactive substances created in the body that may injure cells.*

Garlic taken for 1-2 months improved the level and activity of antioxidant enzymes in the red blood cells of healthy volunteers.31,32*

3FTFBSDI�TVHHFTUT�UIBU�VTF�PG�HBSMJD�TVQQPSUFE�UIF�CPEZ×T�OPSNBM�EFUPYJçDBUJPO�QSPDFTTFT�PG�potentially detrimental dietary substances in healthy volunteers.33*

Page 40

Quality is our PassionMediHerb products are developed CZ�FYQFSUT�BOE�MFBEFST�JO�UIF�çFME�PG�IFSCBM�UIFSBQZ �VTJOH�TDJFOUJçD�FWJEFODF�BOE�IVOESFET�PG�ZFBST�PG�USBEJUJPOBM�knowledge.

Kerry Bone and over 20 health care QSPGFTTJPOBMT�XPSL�XJUIJO�.FEJ)FSC�while still managing their own clinical practices, plus we consult XJUI�BO�BEWJTPSZ�CPBSE�PG�IFBMUI�DBSF�QSPGFTTJPOBMT�GSPN�BSPVOE�UIF�XPSME�

Our products are made using only the highest quality ingredients which BSF�FYUFOTJWFMZ�UFTUFE�GPS�QVSJUZ�BOE�QPUFODZ��5IF�.FEJ)FSC�NBOVGBDUVSJOH�plant operates to a strictly regulated pharmaceutical standard and is regularly audited by the Therapeutic Goods Administration (similar to the FDA), the same body that audits conventional QIBSNBDFVUJDBM�NBOVGBDUVSJOH�GBDJMJUJFT��The comprehensive regulations in Australia mean that you receive a TBGF�BOE�FGGFDUJWF�QSPEVDU�UIBU�IBT�CFFO�NBOVGBDUVSFE�UP�QIBSNBDFVUJDBM�standards.

8F�LOPX�GSPN�PVS�FYQFSJFODF�BT�IFBMUI�DBSF�QSPGFTTJPOBMT�UIBU�UIF�RVBMJUZ�PG�B�QSPEVDU�ZPV�UBLF�NBLFT�B�IVHF�EJGGFSFODF�UP�UIF�IFBMUI�PVUDPNF�ZPV�experience. We dedicate ourselves to researching and making the best possible products to deliver health solutions that work.




What Makes MediHerb Garlic Forte UniqueGarlic Forte is unique in the professional herbal products industry because:

The label states exactly how much each tablet contains of the important plant constituent (alliin)

MediHerb tests the quantity of alliin in garlic raw material

MediHerb tests that alliinase is present and active in garlic raw material

MediHerb’s testing ensures the alliin and alliinase are retained in the product throughout manufacture

MediHerb’s testing also ensures that the alliinase is protected from stomach acid by correct enteric coating, and the tablet disintegrates under simulated gastrointestinal conditions to release allicin




� �3BX�NBUFSJBMT�BOE�çOJTIFE�QSPEVDU�BSF�TVCKFDUFE�UP�UPVHI�RVBMJUZ�TUBOEBSET �JODMVEJOH�VTF�of the latest and most relevant chemical analysis methods

References1 Rahman K, Lowe GM. J Nutr 2006; 136(3 Suppl): 736S-740S2 Cronin JR. Altern Complement Ther 2001; 7(3): 166-1703 Rivlin RS. J Nutr 2001; 131(3s): 951S-954S4 Lawson LD, Bauer R (eds). Phytomedicines of Europe: Chemistry and Biological Activity. ACS Symposium Series 691. American Chemical

Society, Washington DC, 1998.5 Lawson LD, Gardner CD. J Agric Food Chem 2005; 53(16): 6254-62616 Lawson LD, Wang ZJ, Papadimitriou D. Planta Med 2001; 67(1): 13-187 Product Review: Garlic Supplements. Initial Posting: 21 June 2006, updated: 4 September 2006. Available by subscription from

www.consumerlab.com. Accessed 15 November 2006.8 Lawson LD, Wang ZJ. J Agric Food Chem 2001; 49(5): 2592-25999 Reinhart KM, Talati R, White CM et al. Nutr Res Rev 2009; 22(1): 39-4810 Kannar D, Wattanapenpaiboon N, Savige GS et al. J Am Coll Nutr 2001; 20(3): 225-23111 Sobenin IA, Andrianova IV, Demidova ON et al. J Atheroscler Thromb 2008; 15(6): 334-33812 Sobenin IA, Pryanishnikov VV, Kunnova LM et al. Lipids Health Dis 2010; 9: 11913 Sobenin IA, Nedosugova LV, Filatova LV et al. Acta Diabetol 2008; 45(1): 1-614 Kiesewetter H, Jung F, Pindur G. Int J Clin Pharmacol Ther Toxicol 1991; 29(4): 151-15515 Kiesewetter H, Jung F, Jung EM et al. Eur J Clin Pharmacol 1993; 45(4): 333-33616 Reinhart KM, Coleman CI, Teevan C et al. Ann Pharmacother 2008; 42(12): 1766-177117 Anim-Nyame N, Sooranna SR, Johnson MR et al. J Nutr Biochem 2004; 15(1): 30-3618 Koscielny J, Klussendorf D, Latza R et al. Atherosclerosis 1999; 144(1): 237-24919 Vastag B. JAMA 2002; 288(11): 134220 Galeone C, Pelucchi C, Levi F et al. Am J Clin Nutr 2006; 84(5): 1027-103221 Sengupta A, Ghosh S, Bhattacharjee S. Asian Pac J Cancer Prev 2004; 5(3): 237-24522 Harris JC, Cottrell SL, Plummer S et al. Appl Microbiol Biotechnol 2001; 57(3): 282-28623 Weiss E. Med Rec 1941; 153: 404-40824 Soffar SA, Mokhtar GM. J Egypt Soc Parasitol 1991; 21(2): 497-50225 Farbman KS, Barnett ED, Bolduc GR et al. Pediatr Infect Dis J 1993; 12(7): 613-61426 Bolton S, Null G, Troetel WM. Am Pharm 1982; NS22(8): 40-4327 British Herbal Medicine Association’s Scientific Committee. British Herbal Pharmacopoeia. BHMA, Bournemouth, 1983.28 Felter HW, Lloyd JU. King’s American Dispensatory. 18th Edn, 3rd revision. First published 1905, reprinted Eclectic Medical Publications,

Portland, 1983.29 Dietz DM, Varcelotti JR, Stahlfeld KR. Burns 2004; 30(6): 612-61330 Josling P. Adv Ther 2001; 18(4): 189-19331 Avci A, Atli T, Ergüder IB et al. Gerontology 2008; 54(3): 173-176 32 Grune T, Scherat T, Behrend H et al. Phytomed 1996; 2(3): 205-20733 Mei X, Lin X, Liu J et al. Acta Nutr Sin 1989; 11: 141-146


Page 41




Cayenne PepperCayenne Pepper Works as an Effective Catalyst for Herbal and Nutritional Supplementation

Cayenne pepper, a member of the Capsicum species, can be used to enhance

flavor and turn up the heat in some of our favorite dishes, or it can be ingested

for a number of health-supporting purposes. The use of cayenne pepper dates

back some 9,000 years. The Aztec Indians referred to this type of pepper as

“chilli,” and many Native Americans have used cayenne pepper both in cooking

and for health. Native to tropical climates, the first archeological evidence of this

pepper’s cultivation was discovered in Mexico, dating back nearly 7,000 years.

Cayenne pepper was later introduced in Europe and finally transported to most

tropical, subtropical, and temperate zones around the globe. The health-related

history of cayenne pepper began with traditional Indian Ayurvedic practitioners

and continued with the Chinese, Japanese, and Korean traditional practices. The

vitamins, minerals, and compounds found in cayenne pepper work to cleanse

the system and promote overall health and well-being.†

How Cayenne Pepper Keeps You Healthy

Maintains a healthy digestive system

Cayenne pepper supports digestive system function by helping to cleanse the

digestive tract and reduce gas buildup. Cayenne stimulates gastric juice output.

Gastric juice works to help break down foods in the stomach and acts as a

natural digestive agent.†

Maintains healthy circulation

Cayenne pepper helps support healthy circulation and helps increase peripheral

circulation in particular. Cayenne pepper contains vitamin E, a heart-healthy

antioxidant, in a stable form. Vitamins C and K are nutrients associated with

healthy hemostatic activity. Cayenne pepper contains these nutrients plus other

synergistic cofactors that help support healthy blood flow.†

Enhances metabolic efficiency

Capsaicin, an important compound in cayenne pepper, helps boost energy

expenditure in the body, thereby increasing the basal metabolism rate.†

Strengthens the immune system

Cayenne pepper is one of the better botanical sources of vitamin C and is often

used to induce intense sweating. Cayenne pepper also contains folic and

pantothenic acids, plus the vitamins A and B complex.†

Enhances the efficacy of other herbal and nutritional supplements

Cayenne pepper is a catalyst for other herbs, primarily due to its oleoresin

content, transporting them quickly to where they are needed most.†

Cayen

ne Pepp

er

Introduced in 2001GF V


Suggested Use: One capsule per day, or as directed.


Calories 2

Cayenne Pepper 350 mg (Capsicum annuum) 35,000 Scoville units


Other Ingredients: Cellulose, water, and calcium stearate.

Caution: Exceeding recommended dosage may cause stomach irritation. Keep out of reach of children. Avoid contact with injured or open skin. Avoid use during pregnancy and lactation. Contraindicated with pepper, celery, mugwort, and birch-pollen allergies.


Page 42


Cayenne PepperWhat Makes Cayenne Pepper Unique


�i Each capsule contains 350 mg (35,000 Scoville units) of cayenne pepper


�i The nutrients in Cayenne Pepper are processed to remain intact, complete nutritional compounds






Studies on nutrients generally use large doses and these studies, some of which are cited below, are the basis for much of the information we provide you in this publication about whole food ingredients. See the supplement facts for Cayenne Pepper.

Anderson L.E. 1998. Mosby’s Medical, Nursing, & Allied Health Dictionary. 5th ed. St. Louis, MO: Mosby: 258.

Balch J.F., Balch P.A. 1997. Prescription for Nutritional Healing. 2nd ed. Garden City Park, NY: Avery Publishing Group: 67.

Borrelli F., Izzo A.A. 2000. The plant kingdom as a source of anti-ulcer remedies. Phytotherapy Research 14(8): 581-591.

Cayenne. http://www.herbsfirst.com/NewsLetters/0299cayenne.html. Online. 24 Oct 2000.

Iorizzi M., et al. 2001. New glycosides from Capsicum annum L. var. acuminatum. Isolation, structure determination, and biological activity. Journal of Agriculture and Food Chemistry 49(4): 2022-2029.

Mills S., Bone K. Principles and Practice of Phytotherapy. New York, NY: Churchhill Livingstone: 13, 41-42, 141, 171, 175, 178, 203, 215.

Pitchford P. 1993. Healing with Whole Foods, Oriental Traditions and Modern Nutrition. Revised ed. Berkeley, CA: North Atlantic Books: 29, 350, 352, 354.

Rau E. 2000. Treatment of acute tonsillitis with a fixed-combination herbal preparation. Advanced Therapy : 17(4): 197-203.

Tsuchiya H. 2001. Biphasic membrane effects of capsaicin, an active component in Capsicum species. Journal of Ethnopharmacology 75(2-3): 295-299.

Yoshioka M., et al. 2001. Combined effects of red pepper and caffeine consumption on 24 h energy balance in subjects given free access to foods. Br J Nutr 85(2): 203-211.

Page 43




Cyruta®

Made From Buckwheat, Containing Powerful Antioxidants

Buckwheat (Fagopyrum esculentum) is typically thought of as a food. Even

though the seeds are used as cereal, the plant is not one of the cereal grasses but

rather a herbaceous plant. Rich in protein (especially lysine, which is uncommon

in most cereal grains), buckwheat also contains vitamins B and E, calcium, and

phosphorus. Buckwheat is easily digestible. It has more iron, copper, and

magnesium than wheat.†

How Cyruta Keeps You Healthy

Buckwheat contains rutin, a powerful antioxidant

Buckwheat contains rutin, a phytochemical of the flavonoid group and a

powerful antioxidant. Rutin protects the body against a variety of damaging

oxidative toxins, especially those released by the body from mineral-fiber

irritation. By itself, rutin is a more potent free-radical eliminator than either

vitamin C or vitamin E. Synergistically, the three work together to create an

antioxidant powerhouse.†

Antioxidants rutin and quercetin help support the skin

Because it is exposed, the skin is particularly vulnerable to environmental

damage, especially from the sun’s rays. Rutin and quercetin protect the skin and

nerves from oxidative damage.†

Soluble fiber and rutin found in buckwheat help maintain the cardiovascular system

The soluble fiber in buckwheat can help maintain a proper balance between

high- and low-density lipoproteins. Furthermore, rutin prevents the oxidation of

low-density lipoprotein in artery walls. As an antioxidant, rutin also minimizes

oxidative damage in red blood cells, especially to delicate cell walls and to

important fats embedded in those walls, and to essential oxygen-carrying

hemoglobin. Rutin also helps keep blood thin, thus encouraging its free flow

through the circulatory system, primarily in peripheral arterial systems.†

Quercetin helps maintain orderly cell growth in breast and other tissues

Quercetin attaches to type-II estrogen-binding sites and helps prevent protein

kinase C activation, a cause of undesirable cell division and growth.†

Cyru

ta®

Introduced in 1948GF

Content: 90 tablets


Supplement Facts: Serving Size: 1 wafer Servings per Container: 100 Amount per Serving %DV

Calories 2

Vitamin C 3 mg 4%

Proprietary Blend: 340 mg Dried buckwheat (leaf) juice, buckwheat (seed), inositol, oat flour, and bovine adrenal Cytosol™ extract.

Each tablet supplies approximately: 245 mg buckwheat leaf juice and seed and 80 mg inositol.

Other Ingredients: Honey, ascorbic acid, and calcium stearate.


Page 44


Cyruta®

What Makes Cyruta Unique


�i Each tablet supplies 245 mg buckwheat leaf juice and seed

�i Contains 80 mg of inositol to maintain capillary health†









�i The nutrients in Cyruta are processed to remain intact, complete nutritional compounds







Studies on nutrients generally use large doses and these studies, some of which are cited below, are the basis for much of the information we provide you in this publication about whole food ingredients. See the supplement facts for Cyruta®.

Affany A., Salvayre R., Douste-Blazy L. 1987. Comparison of the Protective Effect of Various Flavonoids Against Lipid Peroxidation of Erythrocyte Membranes (induced by cumene hydroperoxide). Fundam Clin Pharmacol 1(6): 451-457.

Belcaro G., Errichi B.M., et al. 1989. Treatment of acute superficial thrombosis and follow up by computerized thermography. Vasa 18(3): 227-234.

Belcaro G., Rulo A., Candiani C. 1989. Evaluation of the microcirculatory effects of Venoruton in patients with chronic venous hypertension by Laserdoppler flowmetry, transcutaneous PO2 and PCO2 measurements, leg volumetry and ambulatory venous pressure measurements. Vasa 18(2): 146-151.

Bijlani R.L., Sud S., Sahi A., et al. 1985. Effect of Sieved Buckwheat (Fagopyrum esculentum) Flour Supplementation on Lipid Profile and Glucose Tolerance. Indian J Physiol Pharmacol 29(2): 69-74.

Cappelli R., Pecchi S., et al. 1987. Efficacy of O-(?-Hydroxyethyl)-Rutosides at High Dosage in Counteracting the unwanted activity of Oral Contraceptives on Venous Function. Int J Clin Pharmacol Res 7(4): 291-299.

de Francischi M.L., Salgado J.M., Leitao R.F. 1994. Chemical, nutritional and technological characteristics of buckwheat and non-prolamine buckwheat flours in comparison of wheat flour. Plant Foods Hum Nutr 46(4): 323-329.

Ekestrom S., Sonnenfeld T., Lund F. 1984. The Effect of O-(?-Hydroxyethyl)-Rutosides on Central Haemodynamics During and After Aortocoronary Bypass Surgery. Scand J Thorac Cardiovasc Surg 18(3): 255-258.

Grinberg L.N., Rachmilewitz E.A., Newmark H. 1994. Protective Effects of Rutin Against Hemoglobin Oxidation. Biochem Pharmacol 48(4): 643-649.

He J., Klag M.J., Whelton P.K., et al. 1995. Oats and buckwheat intakes and cardiovascular disease risk factors in an ethnic minority of China. Am J Clin Nutr 61(2): 366-372.

Jelnes R., Gaardsting O., Holm A. 1986. Improvement of Subcutaneous Nutritional Blood Flow in the Forefoot by Hydroxyethylrutosides in Patients with Arterial Insufficiency: Case Studies. Angiology 37(3 Pt 1): 198-202.

Korkina L.G., Durnev A.D., et al. 1992. Oxygen radical-mediated mutagenic effect of asbestos on human lymphocytes: suppression by oxygen radical scavengers. Mutat Res 265(2): 245-253.

Mistry K.J., Krishna M., Bhattacharya R.K. 1997. Modulation of Aflatoxin B1 Activated Protein Kinase C by Phenolic Compounds. Cancer Lett 121(1): 99-104.

Moser M., Ranacher G., Wilmot T.J., et al. 1984. A Double-Blind Clinical Trial of Hydroxyethylrutosides in Meniere’s Disease. J Laryngol Otol 98(3): 265-272.

Negre-Salvayre A., Affany A., Hariton C., et al. 1991. Additional Antilipoperoxidant Activities of Alpha-Tocopherol and Ascorbic Acid on Membrane-Like Systems Are Potentiated by Rutin. Pharmacology 42(5): 262-272.

Negre-Salvayre A., Mabile L., Delchambre J., et al.. 1995. Tocopherol, Ascorbic Acid, and Rutin Inhibit Synergistically the Copper-Promoted LDL Oxidation and the Cytotoxicity of Oxidized LDL to Cultured Endothelial Cells. Biol Trace Elem Res 47(1-3): 81-94.

Negre-Salvayre A., Salvayre R. 1992. Quercetin Prevents the Cytotoxicity of Oxidized LDL on Lymphoid Cell Lines. Free Radic Biol Med 12(2): 101-106.

Piantelli M., Maggiano N., et al. 1995. Tamoxifen and Quercetin Interact with Type II Estrogen Binding Sites and Inhibit the Growth of Human Melanoma Cells. J Invest Dermatol 105(2): 248-253.

Piller N.B., Morgan R.G., Casley-Smith J.R. 1988. A double-blind, cross-over trial of o-(?-hydroxyethyl)-rutosides (benzo-pyrones) in the treatment of lymphoedema of the arms and legs. Br J Plast Surg 41(1): 20-27.

Ranelletti F.O., Ricci R. 1992. Growth-Inhibitory Effect of Quercetin and Presence of Type-II Estrogen-Binding Sites in Human Colon-Cancer Cell Lines and Primary Colorectal Tumors. Int J Cancer 50(3): 486-492.

Sadzuka Y., Sugiyama T., et al. 1997. Protective effect of flavonoids on doxorubicin-induced cardiotoxicity. Toxicology Lett 92(1): 1-7.

Saija A., Scalese M., et al. 1995. Flavonoids as Antioxidant Agents: Importance of their Interaction with Biomembranes. Free Radic Biol Med 19(4): 481-486.

Scambia G., Ranelletti F.O., et al. 1990. Type-II Estrogen Binding Sites in a Lymphoblastoid Cell Line and Growth-Inhibitory Effect of Estrogen, Anti-Estrogen and Bioflavonoids. Int J Cancer 46(6): 1112-1116.

Shimoi K., Shen B., et al. 1997. Protection by G-Rutin, a Water-soluble Antioxidant Flavonoid, against Renal Damage in Mice Treated with Ferric Nitrilotriacetate. Jap Journal of Cancer Res 88(5): 453-460.

Skaper S.D., Fabris M., Ferrari, et al. 1997. Quercetin Protects Cutaneous Tissue-Associated Cell Types Including Sensory Neurons from Oxidative Stress Induced by Glutathione Depletion: Cooperative Effects of Ascorbic Acid. Free Radic Biol Med 22(4): 669-678.

Wojcicki J., Samochowiec L. 1995. Effect of Buckwheat Extract on Free Radical Generation in Rabbits Administered High-fat Diet. Phytother Res 9(5): 323-326.

Page 45




Biost®

A Special Combination Formula That Supports Cellular and Skeletal Health

Bone serves a myriad of functions beyond providing shape and support for the body.

Bone stores essential mineral salts, while bone marrow provides a manufacturing

plant for the formation of blood cells. Manganese is necessary for bone growth,

development, and replacement. Manganese is involved with the health and

maintenance of ligaments and tendons, as demonstrated in numerous animal

studies. Manganese helps to form cartilage and synovial fluid and is required to

synthesize bone. Manganese is also necessary (in small quantities) for protein and fat

metabolism. Manganese supports healthy nerves and strengthens immunity while

also playing a role in blood-sugar regulation and energy production.†

How Biost Keeps You Healthy

Maintains cellular health

Protomorphogen™ extract is the brand name of Standard Process’ extracts

derived from nucleoprotein-mineral molecules. The foundation for the function

of these uniquely formulated, nucleoprotein-mineral extracts comes from the

antigen-antibody reaction that takes place during normal cell maintenance. The

antigenic properties promote healthy cellular division, function, and growth.

When a tissue needs support, at least a dozen different compounds are formed

that can cause white blood cells to travel together toward the compromised area.

These compounds include degenerative products of the tissues themselves. They

strongly activate the macrophage system, and within a few hours, the

macrophages begin to devour the destroyed tissue byproducts. At times, the

macrophages can also affect the structure of the remaining healthy cells. The veal

bone PMG™ extract in Biost appears to neutralize the circulating antibodies,

thereby contributing to the maintenance of cellular health.†

Supports skeletal health

Manganese acts as a catalyst and a cofactor in many enzymatic processes important

in skeletal and connective-tissue development. Manganese is necessary for

appropriate bone growth and development. Manganese plays a prominent role

among the enzymes necessary for mucopolysaccharide synthesis.

Mucopolysaccharide is an important constituent of the bone and cartilage structural

matrix, as well as in the health and maintenance of ligaments and tendons.†

Improves calcium absorption

While many people fail to take in adequate amounts of calcium from their diets,

their calcium intake is further compromised by consuming food or drinks that

inhibit calcium absorption or that contain calcium in a complex state. Calcium

lactate is a very soluble and highly bioavailable calcium salt, changing to calcium

bicarbonate (the type used by the body) in one chemical step. Unlike other

forms of calcium that are largely insoluble in water and need acid conditions in

order to be absorbed, Standard Process’ calcium lactate is highly soluble in

water (a neutral pH) and does not depend on acidic conditions to function.†

Biost

®

Introduced in 1954GF

Content: 90 tablets 360 tablets


Supplement Facts: Serving Size: 1 tablet Servings per Container: 90 or 360 Amount per Serving %DV

Calories 1

Manganese 6 mg 300%

Sodium 10 mg <1%


Proprietary Blend: 250 mg Veal bone PMG™ extract, calcium lactate, and magnesium citrate.

Other Ingredients: Manganese lactate, honey, cellulose, and calcium stearate.

Each tablet supplies approximately: 170 mg veal bone PMG™ extract.


Page 46


Biost®

What Makes Biost Unique

Product AttributesContains a unique blend of ingredients for a variety of nutritional benefits

�i Veal bone PMG™ extract contains bone tissue and bone marrow, providing natural support for the healthy formation of red blood cells†



�i Help provide cellular support and rehabilitation to the corresponding human tissues


The calcium lactate in Biost is a pure-vegetable source of calcium

�i Not derived from a dairy source

Manufacturing and Quality-Control ProcessesLow-temperature, high-vacuum drying technique



�i The nutrients in Biost are processed to remain intact, complete nutritional compounds






Studies on nutrients generally use large doses and these studies, some of which are cited below, are the basis for much of the information we provide you in this publication about whole food ingredients. See the supplement facts for Biost®.

Anderson L.E. 1998. Mosby’s Medical, Nursing, & Allied Health Dictionary. 5th ed. Mosby: St. Louis. 213, 985.

Aschner M., et al. Manganese uptake and distribution in the central nervous system. Neurotoxicology. Apr-Jun 1999; 20(2-3): 173-180.

Balch J.F., Balch P.A. 1997. Prescription for Nutritional Healing. 2nd ed. Avery Publishing Group: Garden City Park. 26-27.

Carter S.D., et al. Effects of porcine somatotropin on calcium and phosphorus balance and markers of bone metabolism in finishing pigs. Journal of Animal Science. Aug 1999; 77(8): 2163-2171.

Dale L., Jones C.M. BMP signaling in early Xenopus development. Bioessays. Sep 1999; 21(9): 751-760.

Fechter L.D. Distribution of manganese in development. Neurotoxicology. Apr-Jun 1999; 20(2-3): 197-201.

Finley J.W. Manganese absorption and retention by young women is associated with serum ferritin concentration. American Journal of Clinical Nutrition. Jul 1999; 70(1): 37-43.

Geesink R.G., et al. Osteogenic activity of OP-1 bone morphogenetic protein (BMP-7) in a human fibular defect. British Journal of Bone and Joint Surgery. Jul 1999; 81(4): 710-718.

Gong H., Amemiya T. Corneal changes in manganese-deficient rats. Cornea. Jul 1999; 18(4): 472-482.

Goud S.N. Effects of sublethal radiation on bone marrow cells: induction of apoptosis and inhibition of antibody formation. Toxicology. Jul 15 1999; 135(2-3): 69-76.

Greger J.L. Nutrition versus toxicology of manganese in humans: evaluation of potential biomarkers. Neurotoxicology. Apr-Jun 1999; 20(2-3): 205-212.

Guyton A.C., Hall J.E. Genetic Control of Protein Synthesis, Cell Function, and Cell Reproduction. Textbook of Medical Physiology. 37

Guyton A.C., Hall J.E. Inflammation and function of macrophages. Textbook of Medical Physiology. 9th ed. 439.

Guyton A.C., Hall J.E. White blood cells and chemotactic attraction. Textbook of Medical Physiology. 9th ed. 434.

Keen C.L., et al. Nutritional aspects of manganese from experimental studies. Neurotoxicology. Apr-Jun 1999; 20(2-3): 213-223.

Kiningham K.K., et al. Overexpression of manganese superoxide dismutase protects against mitochondrial-initiated poly (ADP-ribose) polymerase-mediated cell death. FASEB J. Sep 1999; 13(12): 1601-1610.

Lai J.C., et al. Manganese mineral interactions in brain. Neurotoxicology. Apr-Jun 1999; 20(2-3): 433-444.

Leibovitz B. 1991. Nutrition Update. 5(2).Mori T., et al. Substance P Regulates the Function of Rabbit Cultured

Osteoclast; Increase of Intracellular Free Calcium Concentration and Enhancement of Bone Resorption. Biochemical Biophysical Research Communication. Aug 27 1999; 262(2): 418-422.

Pfeiffer C.C. 1978. Zinc and Other Micronutrients. 66. Sziraki I., et al. Implications for atypical antioxidative properties of manganese

in iron-induced brain lipid peroxidation and copper-deficient low density lipoprotein conjugation. Neurotoxicology. Apr-Jun 1999; 20(2-3): 455-66.

Taal M.W., et al. Risk factors for reduced bone density in haemodialysis patients. Nephrol Dial Transplant. Aug 1999; 14(8): 1922-1928.

Taber’s Cyclopedic Medical Dictionary. 18th ed. 1997. 248.van Mossevelde B. Culinary Cures: Calcium Fortification. Food Product

Design. Sept 1997. 69-70.

Page 47




Introduced in 1934 GF V

Content: 90 tablets

Suggested Use: One tablet per day, or as directed.

Supplement Facts: Serving Size: 1 tablet Servings per Container: 90 Amount per Serving %DV

Calories 1


Vitamin D 800 IU 200%

Calcium 20 mg 2%

Ingredients: Calcium lactate, milk powder, potassium citrate, glycerin, calcium stearate, arabic gum, starch, sucrose (beets), vitamin A palmitate, cholecalciferol, and ascorbic acid.


Cataplex® DSupports Bone Tissue and Increases Bioavailability of Calcium

The vitamin D complex found in Cataplex D supplies essential nutrients for

maintaining healthy bones, muscle, teeth, and epithelial tissue. Vitamin D plays

an important role in cell replication and tissue formation and helps maintain a

healthy immune system. The vitamin D in Cataplex D increases the availability

and absorption of calcium by all tissues. Vitamin D also helps control blood

levels of calcium and phosphate, which work together at the cellular level to

supply energy and the materials for growth and repair. Calcium also plays a

significant role in the growth process, influencing reproductive health and

keeping bones and teeth at the appropriate density for proper growth and

maintenance. Vitamin A is essential to the normal growth process and is also

supportive of reproductive health.†

How Cataplex D Keeps You Healthy

Builds strong bones and teeth

Vitamin D maintains calcium and phosphate levels to ensure correct

mineralization of bones. Vitamin D also plays a role in calcium absorption.

Vitamin D requires several other nutrients for assimilation, including the

calcium and the vitamin A present in Cataplex D. The human body contains

more calcium than any other mineral. Almost 90 percent of that calcium is used

in the bones and teeth.†

Supports normal growth and reproductive health

Vitamin A is essential to the synthesis of ribonucleic acid (RNA) in its role in the

normal growth process. Vitamin A also supports reproductive health by

participating in both RNA and protein synthesis. Vitamin A helps support

healthy sperm in males and helps support healthy pregnancy in females. Calcium

works with phosphorus at the cellular level, reacting with proteins, fats, and

carbohydrates to supply energy and the materials for proper growth and repair

of cells.†

Promotes healthy immune function

Vitamin D is recognized as fundamental to the development and control of

important cells in the immune system, including lymphocytes and macrophages.

Vitamin D acts on immune cells, producing a variety of chemical messengers.

Adequate levels of vitamin D are required in these processes to maintain the

integrity of the immune system.†

Cataplex

® DPage 48


Cataplex® DWhat Makes Cataplex D Unique

Product AttributesContains cholecalciferol (vitamin D

3)

�i The most important naturally occurring form of vitamin D







Studies on nutrients generally use large doses and these studies, some of which are cited below, are the basis for much of the information we provide you in this publication about whole food ingredients. See the supplement facts for Cataplex® D.

Balch J.F. 1997. Prescription for Nutritional Healing: A Practical A to Z Reference to Drug-free Remedies Using Vitamins, Minerals, Herbs & Food Supplements. 6-9, 18-21.

Barger-Lux M.J., Heaney R.P. 1994. The role of calcium intake in preventing bone fragility, hypertension, and certain cancers. Nutrition Journal 124(8Suppl): 1406S-1411S.

Berdanier C.D. 1995. Advanced Nutrition Micronutrients. Boca Raton, FL: CRC Press Inc: 22-37.

Blythe S. Dietary Calcium to Prevent Osteoporosis. Brevard Health. OnlineCompston J.E. 1998. Vitamin D deficiency: time for action. BMJ 37(28):

1466-1467.Davies P.S., Bates C.J., et al. 1999. Vitamin D: seasonal and regional

differences in preschool children in Great Britain. Eur J Clin Nut 53, 195-198.

Health tips. How to make sure you get enough vitamin D. Mayo Clin Health Lett 1998: 16(11): 3.

Mawer E.B. 1997. Vitamin D Deficiency in Patients with Intestinal Malabsorption. Nutrition 13: 814-824.

Rock C.L., Thronquist M.D., et al. 1998. Demographic, Dietary and Lifestyle Factors Differentially Explain Variability in Serum Carotenoids and Fat-Soluble Vitamins: Baseline Results from the Sentinel Site of the Olestra Post-Marketing Surveillance Study. Am Soc Nutr Sciences 855-864.

Scheider W.L. 1983. Nutrition, Basic Concepts and Applications. New York, NY: McGraw-Hill Book Company: 199-200.

Shils M.E., Young V.R. 1988. Modern Nutrition in Health and Disease. 7th ed. Philadelphia, PA: Lea & Febiger: 292-310.

Sowers M.F., Lachance L. 1999. Vitamins and Arthritis. Rheum Dis Clin NA 25(2): 315-331.

Waiters B., Godel J. 1998. Perinatal Vitamin D and Calcium Status of Northern Canadian Mothers and Their Newborn Infants. J Am Coll Nut 18(1): 122-126.

West-Suitor C.J., Forbes-Crowley M. 1984. Nutrition, Principles and Application in Health Promotion. 2nd ed. Philadelphia, PA: J.B. Lippincott Company: 42-43.

Whitfield J.F. 1990. Calcium, Cell Cycles, and Cancer. Boca Raton, FL: CRC Press Inc: 7-32.

Page 49






Gotu Kola Complex: Tissue Support Formula Gotu Kola Complex is a unique combination of Gotu Kola herb and concentrated extracts of Grape Seed and Ginkgo leaf that supports the normal tissue repair process.*

Clinical trials suggest that to be effective Gotu Kola and Grape Seed extract should contain substantial levels of the important plant constituents: triterpenes and procyanidins respectively.1,2 Standardized Ginkgo extract, containing 24% ginkgo flavonglycosides (ginkgo flavone glycosides) has been also extensively investigated in clinical trials.2 ‘Standardized’ means the extracts must contain a certain amount of important constituents.*

Healthy tissues

Connective tissue gets its name because of its function: it connects other tissues and body systems. Collagen and elastin are important components of connective tissues. The normal processes of tissue repair are mostly a function of connective tissues.3,4 Another type of tissue is epithelial tissue. The outer layer of skin is epithelial tissue; beneath this is the dermis made of connective tissue. Because blood vessels do not occur in epithelial tissues, the connective tissue layer is essential so the epithelial cells can receive nutrients from the blood vessels in the connective tissue beneath.3*

How Gotu Kola Complex Keeps You HealthyPromotes healthy tissues, supports capillary integrity and the body’s normal tissue repair process

The triterpenes of Gotu Kola have been used clinically to support the normal repair process of skin.5,6 Gotu Kola has been used traditionally to help maintain healthy tissue fluid levels during the normal repair processes of skin, muscles and cartilage.7*

Capillaries are very small blood vessels that are in close contact with the surrounding tissues. The fluids that nourish these tissues, the wastes that are excreted, the oxygen, water and food that are absorbed all enter and leave via the capillaries.3 In mostly uncontrolled clinical trials, standardized Grape Seed extract promoted healthy blood vessel walls and healthy capillaries. This helped prevent leakage of fluid from the capillaries to the surrounding body tissues.8-12 These activities have also been shown clinically for the triterpenes of Gotu Kola.1,13,14 The results from one trial suggest that the triterpenes of Gotu Kola provide benefit by helping maintain normal, healthy connective tissue in the walls of veins.13*

Supplement Facts



Gotu Kola herb 10:1 extract 250 mg † from Centella asiatica herb 2.5 g Containing triterpenes 50 mg

Grape seed 120:1 extract 30 mg † from Vitis vinifera seed 3.6 g

Containing procyanidins 25.5 mg

Ginkgo leaf 50:1 extract 20 mg †

from Ginkgo biloba leaf 1.0 g

Containing ginkgo flavonglycosides 4.8 mg

Containing ginkgolides & bilobalide 1.2 mg† Daily Value (DV) not established.

Other ingredients: Calcium acid phosphate, cellulose, sodium starch glycollate, magnesium stearate and hypromellose.

Caution: Contraindicated in known allergy to Gotu Kola. Not to be used during pregnancy and lactation unless otherwise directed by a qualified health care professional.


Gotu Kola ComplexM1313

Gotu Kola Complex M

1313Page 50








Experiments in test tubes are often conducted to learn more about how herbal extracts work in the body. These tests suggest that the triterpenes of Gotu Kola support existing collagen and promote the normal synthesis of collagen in the skin and vein wall.1,15 These triterpenes also support the epithelial cells in the inner layer of veins.1 The procyanidins of Grape Seed also support existing collagen and elastin within vein walls.2*

Gotu Kola is recommended traditionally to support healthy stomach and duodenal tissue.16 The benefit of this traditional use has also been shown in uncontrolled trials using the triterpenes of Gotu Kola.17*

Supports healthy circulation

In a controlled clinical trial, standardized Ginkgo extract enhanced healthy blood flow in the capillaries of the fingers.18 Enhanced circulation is an important factor in supporting the healing process in tissues throughout the body. Healthy circulation provides the tissues with oxygen, nutrients and the substances used by the body in the normal repair process.*

What Makes Gotu Kola Complex UniqueGotu Kola Complex is unique in the professional herbal products industry because:

The label states exactly how much each tablet contains of the important plant constituents (ginkgo flavonglycosides, ginkgolides, bilobalide)


triterpenes in Gotu Kola

procyanidins in Grape Seed extract

ginkgo flavonglycosides (quercetin, kaempferol, isorhamnetin) in Ginkgo

MediHerb’s testing also ensures the triterpenes are retained in the product throughout manufacture





References1 Incandela L, Cesarone MR, Cacchio M et al. Angiology 2001; 52(Suppl 2): S9-S132 McKenna DJ, Jones K, Hughes K et al. Botanical Medicines: The Desk Reference for Major Herbal Supplements, 2nd Edn. New York, Haworth Herbal Press, 2002.3 Lazaroff M. The Complete Idiot’s Guide to Anatomy & Physiology. Alpha, Indianapolis, 2004.4 Wheater PR, Burkitt HG, Daniels VG. Functional Histology: A Text and Colour Atlas. Churchill Livingstone, Edinburgh, 1979.5 Bosse JP, Papillon J, Frenette G et al. Ann Plast Surg 1979; 3(1): 13-216 Huriez CL, Martin P. Lille Med 1972; 44(9): 463-4647 Pharmacopoeia Commission of the People’s Republic of China. Pharmacopoeia of the People’s Republic of China, English Edn. Chemical Industry Press, Beijing, 1997.8 Dubos G, Durst G, Hugonet R et al. Rev Geriatrie 1980; 5(6): 302-3059 Dartenuc JY, Marache P, Choussat H. Bordeaux Med 1980; 13(18): 903-90710 Costantini A, De Bernardi T, Gotti A. Minerva Cardioangiol 1999; 47(1-2): 39-4611 Vérin Ph, Vildy A, Maurin JF. Bordeaux Med 1978; 11(16): 146712 Fromantin M. Med Intern 1981; 16(11): 432-43413 Arpaia MR, Ferrone R, Amitrano M et al. Int J Clin Pharmacol Res 1990; 10(4): 229-23314 Montecchio GP, Samaden A, Carbone S et al. Haematologica 1991; 76(3): 256-25915 Brinkhaus B, Lindner M, Schuppan D et al. Phytomedicine 2000; 7(5): 427-44816 Noumi E, Dibakto TW. Fitoterapia 2000; 71(4): 406-41217 World Health Organization. WHO Monographs on Selected Medicinal Plants, Vol 1. WHO, Geneva, 1999.18 Jung F, Mrowietz C, Kiesewetter H et al. Arzneim Forsch 1990; 40(5): 589-593


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Associate Professor Kerry BoneMediHerb Co-Founder and Director of Research and Development



Bone Complex: Flavonoids for Structural SupportBone Complex is a unique combination of Epimedium aerial parts, Kudzu root, Red Clover flowering tops and Black Cohosh root. Three of these herbs contain flavonoids which may support healthy bones. Flavonoids are a large group of naturally occurring compounds (many are found in foods), and are classified by structure into several groups including flavonols and isoflavones.*

Bone: structure & function

Connective tissue protects and supports the body and its organs. Bone is one type of connective tissue. The functions of bones include support (eg posture), protection (eg of the brain, spinal cord), motion, mineral storage (mostly calcium and phosphate), energy storage (eg fat-rich yellow marrow) and production of blood cells (occurs in the red marrow). Bone is a tissue that is constantly changing. Like other connective tissue, bone is made up of collagen, but unlike other connective tissue it also contains a lot of calcium salts, mainly calcium phosphate. The combination of collagen and calcium phosphate makes bones strong yet flexible. Some bones grow for your entire life, others stop growing (in length) in your twenties. Bones are not uniformly solid and they are made up of many parts. Several of these parts, including the periosteum, a thin membrane covering the outside of the bone, contain the cells necessary for the growth and repair of bone.1-3*

Healthy bones: breaking down & building up

Bones cannot grow continually. As the width of a bone increases, the marrow cavity needs to remain the same size relative to the length of the bone, so some of the cells in the walls of the cavity are destroyed. In addition to this, the body’s tissues need a certain amount of calcium (eg for muscle contraction, nerve conduction), so the matrix part of the bone is broken down (to release calcium). The matrix can also be rebuilt to deposit calcium. This breaking down and rebuilding is called remodeling. As well as allowing the body to store calcium, remodeling allows worn or stressed bone to be removed and replaced with new bone tissue.1,2*

The cells responsible for bone growth are called osteoblasts (osteo = bone, blast = bud). Osteoclasts are the cells responsible for the breakdown (osteo = bone, clast = break) and removal (called resorption) of bone tissue.1,2*

Normal bone growth in children and adolescents, and replacement of bone tissue in adults depend on several factors including sufficient quantities of calcium and phosphorus in the diet, sufficient vitamins A, C and D and the manufacture of the proper amounts of the certain hormones in the body. Bones respond to stress by increasing osteoblast activity, leading to an increase in bone formation and/or bone density. Physical activity is an example of one such stress: a physically active person doing weight-bearing exercise can build stronger bones.1,2*

Supplement Facts

Serving size: 1 tabletServings per container: 40

Amount per Serving %DVCalories 3Calcium 40 mg 4%

Epimedium herb top 12:1 extract 200 mg †

from Epimedium sagittatum herb top 2.4 gContaining icariin 20 mg

Red Clover herb flowering top 5:1 extract 100 mg †

from Trifolium pratense herbflowering top 500 mgContaining isoflavones 8 mg

Kudzu root 10:1 extract 70 mg †

from Pueraria lobata root 700 mgContaining puerariae isoflavones calculated asdaidzin, puerarin, daidzein 28 mg

Black Cohosh root 4:1 extract 20 mg †

from Cimicifuga racemosa root 80 mg† Daily Value (DV) not established.

Other ingredients: Cellulose, calcium acid phosphate, sodium starch glycollate, maltodextrin, hypromellose and magnesium stearate.

Caution: Contraindicated in pregnancy, lactation and in women with estrogen-dependent tumors such as breast cancer. Caution in patients with liver problems, who frequently use alcohol or take medications.


Bone ComplexM1145

Bone Complex M

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Battle of the bone cells?

After childhood, remodeling usually occurs at a balanced rate: for every bone unit that is broken down, another is rebuilt. The rate of remodeling varies according to the part of the bone and the location of the bone. However, at midlife, particularly for women, the osteoblasts become less active leading to a decrease in bone mass. Other factors that can contribute to a decrease in bone mass in later years include cigarette smoking, excessive intake of alcohol and use of certain prescription drugs.1-3*

How Bone Complex Keeps You Healthy Supports bone health

Randomized, double-blind, placebo-controlled clinical trials have found that Black Cohosh and the flavonoids in Epimedium, Kudzu and Red Clover help keep bones strong and healthy.4-8 This is particularly the case in mature women, and often in conjunction with weight-bearing exercise and a healthy diet containing food sources of calcium and vitamin D.*

These flavonoids may do this by supporting normal bone remodeling process and optimal repair of bone tissue that has been damaged as a consequence of normal wear and tear and aging. Specifically, this support may be achieved by rebalancing bone remodeling to have a net positive effect on bone formation compared to bone resorption.4,5,7,9*

What Makes Bone Complex UniqueBone Complex is unique in the professional herbal products industry because:

The label states exactly how much each tablet contains of the important plant constituents (icariin, isoflavones of Red Clover and Kudzu)


icariin in Epimedium

isoflavones in Red Clover

isoflavones in Kudzu (as daidzein, daidzin, puerarin)

MediHerb’s testing also ensures the icariin and isoflavones are retained in the product throughout manufacture





Use of the latest and most relevant test methods for the analysis of raw materials and finished products

References1 Lazaroff M. The Complete Idiot’s Guide to Anatomy & Physiology. Alpha, Indianapolis, 2004. 2 Tortora GJ, Anagnostakos NP. Principles of Anatomy and Physiology, 4th Edn. Harper & Row, New York, 1984. 3 U.S. Department of Health and Human Services. Handout on Health: Osteoporosis. NIH Publication No. 07-5158, April 2007. Available online: http://www.niams.nih.gov/Health_Info/Bone/Osteoporosis/osteoporosis_hoh.pdf. Accessed 8 May 2009. 4 Zhang G, Qin L, Shi Y. J Bone Miner Res 2007; 22(7): 1072-1079 5 Marini H, Minutoli L, Polito F et al. Ann Intern Med 2007; 146(12): 839-847 6 Wu J, Oka J, Tabata I et al. J Bone Miner Res 2006; 21(5): 780-789 7 Atkinson C, Compston JE, Day NE et al. Am J Clin Nutr 2004; 79(2): 326-333 8 Wuttke W, Seidlova-Wuttke D, Gorkow C. Maturitas 2003; 44(Suppl 1): S67-S77 9 Morabito N, Crisafulli A, Vergara C et al. J Bone Miner Res 2002; 17(10): 1904-1912


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