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Living and Thriving with Multiple Sclerosis A Holistic Approach to Managing MS
Where evidence-based research fuses with holistic nutrition to transform your
health and wellness
~ Contact info ~
Chantale Michaud, Registered Holistic Nutritionist Email: [email protected] Website: www.eatheallove.com
Never let any medical diagnosis stop you from pursing the best health possible!
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Copyright © Chantale Michaud, 2017. All rights reserved.
* The information is intended for general wellbeing and educational purposes. It is not meant to substitute for the advice of a medical professional and should not be used to diagnose, treat,
cure, or prevent any disease.
Never take any nutritional supplement before talking to your primary health care provider.
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Autoimmunity & Gut Health Multiple Sclerosis and The Leaky Gut Connection
• The human body is host to trillions of bacteria – at least 1,000 different strains. There are exciting studies on this subject, which explore the connection between gut bacteria and several inflammatory, autoimmune conditions.
• Modern day researchers are even suggesting that an imbalance of gut bacteria may have a direct link to multiple sclerosis.
• The gut microbiome (which is just a fancy expression for the microscopic bacteria that live within the intestinal system) play a very important role when it comes to the development and progression of autoimmune conditions.
• In a study published in the journal Scientific Reports, a team of researchers found that MS patients have a distinct microbiome compared to their healthy peers.
• The study in question found that the gut bacteria in patients with remitting relapsing MS was not significantly different from that of the healthy controls. However, when RRMS patients were further divided into groups that separated those with active disease and those in remission, there was less diverse gut bacteria in the patients in active relapse compared to the healthy controls.
Not all gut bacteria are created equal!
• The “good” bacteria in the gut help to digest food, manufacture specific vitamins, and protect the lining of the digestive tract.
• The “bad” bacteria can lead to digestive disturbances, contribute to brain fog, and inflames the digestive tract.
• Any factors that irritate or stress the digestive tract can lead to systemic, wide-‐spread inflammation. By controlling inflammation in the digestive tract, we can begin to balance the immune system and potentially stop it from sending an inappropriate immune system response, which causes the body to attack its own tissues.
• The more we learn about our own inner ecology, the more we discover just how influential this internal environment is.
4 Understanding the Digestive System
• The act of digestion begins when we indulge in the idea of eating, before we ever put food in our mouth. • Have you ever noticed that when you sit down to a well-‐anticipated meal, your mouth begins to water? That mouth watering affect is your body’s way of preparing your stomach for incoming food. And the saliva that starts to well up in your mouth contains digestive enzymes. • The primary enzyme within the saliva is called amylase, and its function is to break down starches and carbohydrates into sugars. • The enzymes in saliva signal the stomach that food is on its way and in response, the stomach begins producing stomach acid, which helps in the breakdown of protein. • After being chewed and swallowed, the food enters the esophagus. The esophagus is a long tube that runs from the mouth to the stomach. It uses rhythmic, wave-‐like muscle movements (called peristalsis) to move food from the throat into the stomach. • The stomach, a large sack-‐like organ, churns the food and soaks it in stomach acid. If stomach acid is low, proteins will be harder to break down and digest, which can cause gas and bloating and a meal that “sits heavy” in the stomach. • Once past the stomach, food enters the duodenum, the first part of the small intestine. It then travels through the jejunum and then the ileum (the final part of the small intestine). • In the small intestine, bile (which is produced in the liver and stored in the gall bladder), pancreatic enzymes, and other digestive enzymes produced by the inner wall of the small intestine help in the breakdown of food. • The intestinal wall is constructed of a tight, semi-‐impermeable membrane which allow the passage of nutrients to enter into the bloodstream. This is how we absorb nutrients from our food.
* This is also the stage where serious problems like malabsorption and leaky gut syndrome can occur!
• In a healthy digestive tract, the intestinal wall does not allow large protein molecules to pass through the membrane barrier, meaning proteins won’t be absorbed into the bloodstream unless they are completely broken down into single amino acids. • When digestion is compromised in any way (due to food intolerances, poor eating habits, stress, low stomach acid, candida overgrowth etc.), irritation in the digestive tract occurs. • This irritation inflames the intestinal walls and causes the tight junctions to loosen and become “leaky”. This is commonly referred to as “leaky gut syndrome” or hyperpermeability of the small intestine.
5 • This leaky intestinal wall now allows molecules of partially undigested proteins to slip into the bloodstream where they do not belong. The immune system detects and registers them as foreign invaders, which can trigger an autoimmune response.
But it’s not just partially digested food particles that slip into the
bloodstream when someone has leaky gut! • Pathogens, toxins, and other types of metabolic waste that are normally screened out are also capable of circulating throughout the bloodstream through the leaky intestinal walls. • Insufficiently broken-‐down food particles or toxins may also cause the liver to work much harder, which makes is much more difficult for the body to keep up with all the detoxification demands sent its way, and the toxin load starts building up. • Substances leaking through the intestinal lining can even worsen muscle or joint pain, aggravating them to the point of inflammation, or contribute to inflammation already present in the body.
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7 Causes of Inflammation Contributing to
Leaky Gut Syndrome
1. Poor Digestive Health 2. Yeast/Candida Overgrowth 3. Inflammatory Diet 4. Impaired Liver Function 5. Medications 6. Environmental Toxins 7. Chronic Stress 1) Poor Digestive Health One of the major ways we can work towards balancing our gut bacteria is by improving digestion. An inability to fully breakdown and digest proteins can result in a meal that takes longer to digest. The longer food remains stagnant inside the intestinal system, the more gases and toxins are created (which act as fuel for the wrong types of bacteria). To improve digestive function, try following the simple suggestions listed below:
• Eat slowly and chew well – to stress and rush through a meal impairs digestion by allowing too much air to mix with the food, and prevents saliva (which contains digestive enzymes to thoroughly coat the meal as we eat).
• To maximize digestion, it is not advised to drink water (or any other liquid) 30 minutes before or after eating. If you have difficulty swallowing, small sips are acceptable, but take the time to eat slowly and properly chew the food until it becomes a paste in your mouth before swallowing.
• Avoid over-‐consumption – stop eating at a comfortable spot (when you are 80% full). Overeating causes undue stress on the body, which impairs the integrity of the intestinal walls, and can lead to widespread inflammation.
• Populate the gut with “friendly bacteria” by consuming foods that are rich in probiotics. Probiotic foods are those that have been cultured or fermented (such as yogurt, kefir, sauerkraut, miso, tempeh, kimchi and kombucha). * NOTE: If you are using yogurt as a probiotic, it must be plain and unsweetened. If yogurt contains fruit or added sugar, it has no probiotic benefit, no matter what the label may suggest. The healthy bacteria in the yogurt will feed on the fruit in the yogurt, instead of balancing out the bacteria present in your gut. If you use yogurt as a probiotic, choose plain, unsweetened kefir.
• Avoid antacids – the body needs stomach acid to release protein-‐digesting enzymes, kill harmful microbes, and to trigger the release of other digestive enzymes from the pancreas so that food may be properly digested and absorbed. If you suffer from heartburn and/or indigestion, consult a natural health practitioner about addressing the root cause of instead of masking symptoms with antacids or proton pump inhibitors.
• Consider taking a digestive enzyme before meals, but always consult a qualified health practitioner before taking any supplement(s).
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2. Yeast/Candida Overgrowth Candida is a type of yeast that is generally found in the flora of the intestinal system. Although candida organisms are naturally present in the body, they can cause problems if overgrowth occurs, resulting in candidiasis. In chronic candidiasis, rapidly multiplying candida can spread systemically throughout the body. Candida organisms are known to produce over 75 toxic substances. These toxins are absorbed into the bloodstream and carried throughout the body, causing a wide array of symptoms. Yeast produce their energy by converting sugars into carbon dioxide and ethanol, which can cause symptoms such as digestive disturbances, joint pain, and brain fog.
The good bacteria in your system are responsible for keeping candida under control – however, there are many factors which can disrupt this balance, such as antibiotics, birth control pills and oral corticosteroids.
3. Inflammatory Diet There are 5 major points to cover when discussing diet-‐related causes of inflammation in the digestive tract. Each will be briefly discussed below. 1) Processed and Refined Food
Overconsumption of processed foods such as: refined grains, artificial food colorings, flavorings, and preservatives places a lot of stress on the immune system as well as the liver. The body sees most artificial chemicals as toxins. The majority of processed foods are devoid of nutrients, so the amount of energy spent processing them outweighs the nourishment they provide. A diet comprised of processed and refined food will put the body in nutrient debt. The result is increased fatigue, susceptibility to infections, and irritation to the digestive system.
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8 2) Food Sensitivities/Intolerances
Food sensitivities also contribute inflammation in the digestive tract. Since each person has their own unique biochemistry, what contributes to inflammation in one person, might not be an issue for someone else. Any food is capable of initiating an inflammatory response in the body. Food sensitivity testing followed by an elimination diet is key in determining diet-‐related causes of inflammation, as well as addressing the root cause of chronic inflammatory diseases. Top Allergenic Foods: Wheat (gluten), dairy, soy, tomatoes, chocolate
3) Foods Containing Arachidonic Acid
Arachidonic acid is a polyunsaturated omega-‐6 fatty acid, which is necessary for the repair and growth of skeletal muscle tissue. Too much omega-‐6 in the diet however, stimulates the production of pro-‐inflammatory prostaglandins and causes the body to over-‐respond with inflammation during the healing and repair process. When the body is overloaded with arachidonic acid, the inflammatory process is more difficult to halt, or reverse.
Arachidonic acid is found abundantly in the following foods: Trans fats, partially hydrogenated oils, vegetable oil, corn oil, soybean oil, peanut oil, margarine, mayonnaise, eggs, organ meats, red meat, dairy Individuals experiencing both acute or chronic inflammation, or experiencing frequent relapses or symptoms that never go away, could consider limiting or eliminating these foods. Those following a paleo diet who perhaps have a lot of organ meats or red meat in their diet, could perform a hypoallergenic, elimination diet to see if you’re reacting to these foods. Excess insulin also causes the body to turn omega-‐6 fats into arachidonic acid, resulting in an inflammatory response.
4) Nightshades Another possible dietary source of inflammation comes from the nightshade family of plants. While many people have no problems with nightshades, they can cause serious problems for anyone struggling with digestive sensitivities, arthritis, an autoimmune condition, or any other inflammatory condition such as MS. While these foods are not a direct cause of leaky gut, a state of low grade inflammation can prevent the body and digestive tract from healing. You might want to try cutting
Foods in this category contain alkaloids that can affect nerve-‐muscle function, joint flexibility and can contribute to systemic inflammation. Foods of the nightshade family include: Tomatoes, white potatoes, peppers (bell peppers, chili peppers, paprika, tamales, tomatillos, pimentos, cayenne), eggplant, gooseberries, goji berries, tobacco
9 5) Inflammatory Cooking Methods Inflammatory cooking methods involve heating or cooking with vegetable oils, eating heated or roasted nuts and seeds or their oils, and consuming burnt or charred food. The best oils to cook with are saturated fats such as coconut oil, butter or ghee. On a molecular level, these fats are much more heat stable and less likely to create free radicals and promote inflammation. When cooking starchy root vegetables, it is best to steam them. This not only preserves the nutrient value, but also lessens the formation of acrylamide and advanced glycation end products (AGEs), which promote inflammation. Foods Containing Acrylamide Grilling, deep frying and baking all result in the production of acrylamide. Acrylamide is one of the hundreds of chemicals known as Maillard Reaction Products (MRPs). These chemicals form when foods are heated at high temperatures. Studies have shown that acrylamide is a cancer-‐causing and potentially neurotoxic chemical that contributes to oxidative stress and increases the signs of aging. Potato chips, french fries, sweet potato fries, burnt toast, baked goods, grilled or charred food all contain high amounts of acrylamide. Grilled or roasted starchy carbohydrates contain the highest levels. Levels increase the more cooked and browned the food is. In studies, unheated, boiled, or steamed foods show undetectable levels of acrylamide.
4. Impaired Liver Function If the filtering or detoxification systems within the liver are sluggish or inefficient, this will cause toxins, dead cells and microorganisms to build up in the blood stream. A liver working overtime will increase the workload of the immune system, which will stress the body and deplete one of nutrients. The immune system will then produce excessive inflammatory chemicals, and in some cases, auto antibodies. This may lead to symptoms of other immune system dysfunction such as allergies, swollen glands, recurrent infections, chronic fatigue syndrome, fibromyalgia or additional auto-‐immune conditions. Tips to Support Optimal Liver Function • Consume bitter greens and cruciferous vegetables (kale, spinach, dandelion greens, broccoli, cauliflower, Brussels sprouts) • Add turmeric to your meals, or take in supplement form. • Drink lemon water first thing in the morning. • Increase antioxidants by eating berries, pomegranates, kiwi, and red grapes. 5. Medications Medications (antibiotics, NSAIDs, aspirin, antacids, birth control), both prescription and over-‐the-‐counter pain relievers may also lead to increased intestinal permeability.
10 • Many medications are very abrasive to the gastrointestinal lining. Aspirin reduces the thickness of the mucosal lining in the gut, thus making it more susceptible to yeast, inflammation, and irritation. • There is a time and place for life-‐saving medications. If you are taking multiple medications for different health issues, ensure your prescriptions are up-‐to-‐date by having them reviewed by your doctor and pharmacist. • When appropriate, consider natural and holistic methods in place of prescription strength pain medications by consulting with a professional, natural health practitioner. • Treat the root cause, rather than masking symptoms. 6. Environmental Toxins When our natural detoxification system becomes overloaded or dysfunctional, environment toxins may build up and irritate the intestinal lining. • Chronic inflammation and immune system activity can lead to further intestinal permeability. • Lighten your toxic load by switching to more natural, chemical free household and personal care products. Tips to Lighten Your Toxic Load • Follow a natural, whole foods diet. • Drink purified water. • Use glass containers for food storage instead of plastic. • Natural essential oils can be used in place of chemical laden perfumes and air fresheners. • Use green plants as natural air detoxifiers. • Have your home assessed for mold. • Make positivity a habit! Be aware of stress-‐inducing thought patterns and negative thinking. 7. Chronic Stress Chronic stress suppresses the immune system and can alter intestinal physiological function, increase gut permeability, and contribute to inflammation. • A healthy immune system can easily fight pathogens, but a weakened immune system is more susceptible. When the immune system is overactive for an extended period of time, leaky gut can develop. • Help reduce the negative effects of stress by practicing stress management techniques, eating a balanced diet and participating in regular exercise. • Habitual thoughts and actions over time determine our destiny. Allow positive thinking to fuel positive actions and lifelong behaviour! Advances in the mind-‐body sciences are now proving what ancient wisdom traditions have been saying for
centuries – the mind-‐body connection profoundly impact one another.
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Nutrients and Substances That Help Reduce Gut Related Inflammation
This is just a quick list to give you a general idea of the type of nutrients that are required to repair and heal the digestive and intestinal system. Whenever possible, it's best to obtain these nutrients from food instead of
supplements. Zinc (30mg day) Necessary in maintaining intestinal wall integrity -‐ aids in healing a leaky gut.
Kelp, pecans, pumpkin seeds, sunflower seeds, whole grains, alfalfa, cayenne, parsley, chamomile, dandelion, eggs, fish, oysters, liver
Vitamin A/Beta Carotene Vitamin A is found in animal products such as: liver, fish, beef, eggs. Beta carotene is obtained from the plant based foods and converted to Vitamin A in the body. Foods rich in beta carotene include: dark green and orange fruit and vegetables. Carrots, sweet potatoes, yams, winter squash, pumpkin, spinach, collards, kale, turnip greens, beet greens, cabbage, apricots, asparagus, peas, peppers, plums, cantaloupe, mangoes, peaches
Aloe Vera Juice Helps to heal the intestinal tract and kill bad bacteria in the gut. 1oz 3 times a day
Turmeric Potent anti-‐inflammatory (add 3% black pepper for increased absorption). Turmeric can be added to food and smoothies or taken in supplement form
Digestive Enzymes Helps break down food and improves digestion. Look for a full spectrum enzyme. Enzymes help with food intolerances, improve digestion and increase nutrient absorption all at the same time.
Probiotics Probiotics help to restore beneficial intestinal bacteria, improve digestion and assist with nutrient absorption. Look for a multi-‐strain probiotic with at least 20 billion per dose.
B-‐vitamins Aids in healing the intestinal tract and is required for proper nerve function and healing the myelin sheath. Avocado, sunflower seeds, oats, nuts, spinach, peanuts, cauliflower, peas, beans, brazil nuts, pecans, quinoa, millet, hemp seeds, whole grains, sweet potatoes
Vitamin E
Avocado, almonds, hazelnuts, hemp seeds, sunflower seeds, brown rice, eggs, dulse, kelp, oatmeal, sweet potatoes, cold pressed olive oil, squash, pumpkin, tuna, salmon
Slippery Elm Lozenges Slippery elm is used to soothe irritation or ulceration of the stomach and intestines. Allow the lozenge to dissolve slowly in the mouth.
L-‐Glutamine Glutamine is an amino acid that is naturally produced by the body. It is also found in many food sources such as whey protein and bone broth. It helps strengthen the lining of the intestinal tract and allows nutrients to be absorbed more efficiently. Glutamine supplements are not recommended and is best obtained from food sources. Food Sources: Spinach, red cabbage, sauerkraut, parsley, fish, beans, grass fed chicken and beef, whey protein powder, bone broth, collagen supplements