Long-lasting parasite protection for dogs and cats · fortnightly treatments require diligent reapplication. The majority of pet owners only treat for fleas and ticks every 3 months

*Refer to product labels (APVMA 85413, 82804, 82795 & 68873) for full claim details. © 2020 Intervet International B.V. All Rights Reserved. MSD Animal Health. ABN 79 008 467 034. Toll free: 1800 230 833. AU/BRV/0320/0012.

Long-lasting parasite protection for dogs and cats*

Monthly and fortnightly treatments

require diligent reapplication.

The majority of pet owners only treat for fleas and ticks every

3 months or less frequently1.

Inconsistently applied treatments can leave dogs and cats vulnerable to

parasite risks.

There is a gap between what owners perceive their dog or cat needs and what they are actually administering.

WHY IS COMPLIANCE IMPORTANT?

2

Compliance The need for less frequent applications may lead to fewer gaps in protection.

Safe 125 million Bravecto doses have been dispensed in over 85 different countries.

Peace of mind Fewer treatments to remember – less to forget.

ChoiceAvailable in convenient weight ranges to suit all types of cats and dogs.

WH

Y CH

OO

SECHOOSE BRAVECTOLONG-LASTING BENEFITS

HOOKWORMAncylostoma tubaeformeUncinaria stenocephala

ROUNDWORMToxocara catiToxoscaris leonina

HEARTWORMDirofilaria immitis

FLEACtenocephalides felis

FLEAEGGS LARVAE PUPAE

PARASITE PROTECTION

• The cat flea (Ctenocephalides felis) is highly tolerant to a wide range of environmental conditions2.

• Fleas aren’t just an itchy pest to dogs and cats but can also trigger more serious consequences.

• Fleas can also carry immature tapeworm. If an infected flea is ingested by a dog when they are grooming, they can become infested with tapeworm.

• Once an owner sees fleas on their pet, there is already an environmental flea infestation in the form of eggs, larvae and pupae within the home.

• These environmental stages account for 95% of the flea population and due to the required time to pass through the stages of the flea life cycle, it can take 2 months or more to eradicate an infestation3,4.

• This is often frustrating for pet owners, as even after applying a flea treatment, the immature stages are acting as an ongoing source of new adult fleas which infest their pets.

• Sustaining a flea-free household requires year-round protection. Make it easier for pet owners by recommending long-lasting Bravecto.

EGGS

1STAGE

< 10 days2

STAGE

= 10 days3

STAGE

11 days(but can be

months)

4STAGE

< 3 months

ADULTLARVAE PUPAE

BRAVECTO LASTS FOR THE FULL FLEA LIFE CYCLEOne fuss-free dose* of Bravecto covers beyond the length of the average flea life cycle, providing rapid and persistent protection.

FLEASCtenocephalides

felis

*Refer to table on page 14 for the required inter-dosing intervals for the Bravecto range.

FLEAS

4

PARA

SITE

S

PARALYSIS TICKS

• Tick paralysis is caused by the paralysis tick (Ixodes holocyclus).

• Paralysis ticks are unique to Australia and are most commonly found along the eastern seaboard.

• These ticks can cause serious disease and even death in domestic dogs and cats5.

• Paralysis ticks can occur all year round, peaking from August through to March6.

Paralysis Tick Symptoms

• With just one dose*, Bravecto treats and controls pre-existing and new paralysis ticks7,8,9,10.

• Bravecto doesn’t repel ticks - ticks must attach and feed from the animal to be exposed to fluralaner, therefore attached ticks may be seen.

• Daily searching for, and removal of any ticks found is recommended as the risk of tick paralysis cannot be entirely eliminated.

Coughing or gagging due to inability to swallow. Regurgitation or vomiting.

Changes in the sound of bark or meow.

Weakness in front or hind legs.

Rapid or difficulty

breathing.

ADULT FEMALEEngorgement Level



SARCOPTES MITESSarcoptes scabiei

EAR MITESOtodectes cynotis

DEMODEX MITESDemodex spp.


ADULT FEMALEEngorgement LevelADULT MALE




Rapid or difficulty

breathing.









PARALYSIS TICKS

Ixodes holocyclus

• The brown dog tick (Rhipicephalus sanguineus) is the most widely distributed tick species globally and can endure both temperate and tropical climates11.

• These ticks are known to be active in the Northern Territory, Queensland, New South Wales and Western Australia11.

• With one engorged female brown dog tick able to lay up to 4,000 eggs12, not only is this tick a nuisance, but it can also be a vector for a range of tick-borne diseases13.

• One dose* of Bravecto treats and controls the brown dog tick and year-round prevention should be considered for at risk dogs14.

DEMODEX, SARCOPTES AND EAR MITES

• Under certain conditions, dogs and cats can become infested by a group of parasites called mites.

• Clinical signs differ depending on the mite but can include crusty or scaly skin, itching and hair loss15.

• Just one dose* of Bravecto will treat and control demodex mites, sarcoptic mange (caused by Sarcoptes scabiei) and ear mites in dogs.

• Just one dose of Bravecto will treat and control ear mites in cats.




Rapid or difficulty

breathing.












Rapid or difficulty

breathing.









BROWN DOG TICKS


BROWN DOG TICK

Rhipicephalus sanguineus

DEMODEX MITES

Demodex spp.

SARCOPTES MITES

Sarcoptes scabiei

EAR MITES Otodectes

cynotis

ROUNDWORMToxocara cati

Toxoscaris leonina


HOOKWORMAncylostoma tubaeformeUncinaria

stenocephala

6

INTESTINAL WORMS

• Roundworms and hookworms can infect cats16,17.

• These seemingly quiet houseguests can reside in the intestinal tract of cats and cause ill thrift, weight loss, pot-bellied appearance, vomiting and intermittent diarrhoea17.

• Transmission is via the faecal oral route16 and occasionally they can be transmitted to humans16,17.

• One dose* of Bravecto Plus treats roundworm and hookworm infestations.

HEARTWORM

• The prevalence of heartworm infection in cats is between 5% and 10% of that in dogs in any given area18,19.

• No matter how hard we try to avoid mosquitoes, they frequently find a way to our skin and just a single infected mosquito bite can transmit heartworm larvae to a cat19.

• These thread-like worms take up residence in the heart and lungs and can cause coughing, increased respiratory effort, malaise and in severe cases fatal acute lung injury often resulting in death18,19.

• One dose* of Bravecto Plus prevents heartworm disease in cats for 2 months.











BROWN DOG & BUSH TICKS

DEMODEX SARCOPTES EAR MITESPARALYSISTICKS

FLEAS FLEATAPEWORM

AUSTRALIA’S

NO. 1FLEA & TICK TREATMENT

FOR DOGS^

BRAVECTO CHEW FOR DOGS

ONE DOSE, 3 MONTHS FLEA PROTECTIONBravecto Chew for Dogs provides control of fleas within 8 hours of administration20 and subsequently maintains persistent efficacy against flea-reinfestation for 3 months. The rapid onset of action kills newly emerged adult fleas before they lay eggs. Bravecto Chew for Dogs prevents flea tapeworm (Dipylidium caninum) transmission from the infected fleas to susceptible dogs for up to 3 months21.

ONE DOSE, 4 MONTHS PARALYSIS TICK PROTECTIONBravecto Chew for Dogs treats and controls paralysis ticks in dogs for 4 months. Bravecto Chew for Dogs killed 100% of an existing infestation of paralysis ticks within 48 hours of treatment7. After re-infestation, efficacy was 100% within 72 hours at all time points post-treatment for 4 months7.

Ideal for:• Owners who want to dose less

frequently – treat only 4 times a year for flea and paralysis tick protection.

• Dogs that are at risk of flea and flea tapeworm infections.

• Dogs that are at risk of paralysis, brown dog and/or bush ticks.

• Dogs who swim and enjoy water activity frequently.

• Dogs that require treatment and control of ear mites, demodex mites and sarcoptic mange.

• Dogs that love tasty chews.• Breeding, pregnant and lactating

dogs and MDR1 gene deficient breeds22.

• Dogs from 8 weeks of age, weighing at least 2 kg23.

*Refer to table on page 14 for the required inter-dosing intervals for the Bravecto range.^AHA Industry Audit Data, Canine Ectoparasiticides Category, MAT to December 2019.

Covers:

BROWN DOG TICKS

DEMODEX SARCOPTES EAR MITESPARALYSISTICKS

FLEAS FLEATAPEWORM

BRAVECTO SPOT-ON FOR DOGS

ONE DOSE, 6 MONTHS FLEA PROTECTIONBravecto Spot-on for Dogs provides effective control of fleas within 8 hours of administration24 and subsequently maintains persistent efficacy against flea-reinfestation for 6 months. The rapid onset of action kills newly emerged adult fleas before they lay eggs. Bravecto Spot-on for Dogs prevents flea tapeworm (Dipylidium caninum) transmission from infected fleas to susceptible dogs for up to 3 months24.

ONE DOSE, 6 MONTHS PARALYSIS TICK PROTECTIONBravecto Spot-on for Dogs treats and controls paralysis ticks in dogs for 6 months. Bravecto Spot-on for Dogs killed 99.3% of an existing infestation of paralysis ticks within 48 hours of treatment and 100% within 72 hours of treatment9. After re-infestation, efficacy was 100% within 72 hours at all time points, except day 115 when 1 tick was found (99.6% efficacy)9.

It is not recommended to wash or allow the dog to become immersed or swim in water within 3 days after treatment.


Ideal for:• Owners already using a monthly

topical treatment – only treat 2 times a year for flea and paralysis tick protection.

• Owners who prefer the ease and convenience of a spot-on treatment.

• Dogs that are at risk of flea infestations and flea tapeworm infections.

• Dogs that are at risk of paralysis and brown dog ticks.

• Dogs that require treatment and control of ear mites, demodex mites and sarcoptic mange.

• Fussy eaters.• Breeding, pregnant and lactating dogs

and MDR1 gene deficient breeds22.• Dogs from 8 weeks of age, weighing at

least 2 kg24.

RAN

GE

8

Covers:

BRAVECTO SPOT-ON FOR CATS

ONE DOSE, UP TO 3 MONTHS FLEA PROTECTIONBravecto Spot-on for Cats demonstrated 100% flea efficacy within 8 hours after treatment and at least 97.7% efficacy within 12 hours after re-infestation for up to 3 months25. The rapid onset of action kills newly emerged adult fleas before they lay eggs26.

ONE DOSE, 3 MONTHS PARALYSIS TICK PROTECTIONBravecto Spot-on for Cats treats and controls paralysis ticks in cats for 3 months. Bravecto Spot-on for Cats killed 100% of an existing infestation of paralysis ticks within 48 hours of treatment8. After re-infestation, efficacy remained at 100% within 48 hours at all time points8.

ONE DOSE TREATS EAR MITESOne dose of Bravecto was 100% effective against ear mite infestations in cats27.

AUSTRALIA’S

NO. 1FLEA & TICK TREATMENT

FOR CATS^

PARALYSISTICKS

FLEAS EAR MITES

Ideal for:• Owners who want to dose less

frequently – treat only 4 times a year for flea and paralysis tick protection.

• Cats that are at risk of fleas and paralysis ticks.

• Cats that require treatment and control of ear mites.

• Cats from 9 weeks of age and weighing more than 1.2kg27.

*Refer to table on page 14 for the required inter-dosing intervals for the Bravecto range.^AHA Industry Audit Data, Feline Ectoparasiticides Category, MAT to December 2019.

Covers:

Efficacy against key feline nematodes30

Roundworm (Toxocara cati) - L5 and adults 99.97%

Roundworm (Toxascaris leonina) - adults 100%

Hookworm spp. - L4, L5 and adults of Ancylostoma tubaeforme and Uncinaria stenocephala 100%

Heartworm disease prevention31

Heartworm (Dirofilaria immitis) - at 2 months after treatment 100%

FLEAS PARALYSISTICKS

HEARTWORM ROUNDWORM HOOKWORMEAR MITES

ALL-IN-ONE+ PROTECTION, TREAT EVERY 2 MONTHSBravecto Plus is the only spot-on that provides reliable, safe, broad spectrum protection against fleas, worms plus ticks* when applied every 2 months28.

Bravecto Plus kills 100% of fleas within 12 hours of application28. Australian field studies for Bravecto Plus showed >98.9% flea kill efficacy for the entire 3-month period29. Bravecto Plus reduces the incidence of Flea Allergy Dermatitis (FAD) by rapidly killing fleas28.

Bravecto Plus treats and controls paralysis ticks in cats for 10 weeks. Bravecto Plus for Cats killed 99% of an existing infestation of paralysis ticks within 48 hours of treatment10. After re-infestation, efficacy was >98.7% within 72 hours at all time points for 73 days post-treatment10.

Ideal for:• Cat owners who want an ALL-IN-ONE+

product for fleas, paralysis ticks, heartworm, intestinal worms and ear mites.

• Cat owners who prefer to dose less frequently – every 2 months.

• Cats that are difficult to medicate with tablets.

• Cats from 9 weeks of age and weighing more than 1.2kg28.

*Refer to table on page 14 for the required inter-dosing intervals for the Bravecto range.+All-in-one treatment for fleas, paralysis ticks, heartworm, roundworm, hookworm and ear mites. Refer to product label for full claim details.

BRAVECTO PLUS FOR CATS

10

Covers:

BRAVECTO - PROVEN SAFE

• No adverse events have been observed in safety studies with Bravecto Chew, Bravecto Spot-on for Dogs, Bravecto Spot-on for Cats and Bravecto Plus when administered at up to 5 times the maximum dose rate, at 8 weekly intervals32,33,34,35.

• Bravecto Chew and Bravecto Spot-on for Dogs are safe to use in puppies from 8 weeks of age and 2 kg bodyweight23,24.

• Bravecto Spot-on for Cats and Bravecto Plus for cats are safe to use in kittens from 9 weeks of age and 1.2 kg bodyweight26,28.

• Safe to use in breeding, pregnant, lactating dogs and MDR1 deficient dog breeds22,23,24.

• Safety not established in breeding, pregnant or lactating cats.

Over 125 million doses have been dispensed around the world, benefiting dogs, cats and owners from all corners of the globe.

HOW TO USE BRAVECTO’S TWIST’N’USE TUBE

For very large dogs, apply in four spots along the back.

For medium sized dogs, apply in three spots along the back.

For small sized dogs, apply in two spots along the back.

Dogs come in all loveable shapes and sizes. Follow the diagram below and apply the entire contents of the appropriate tube for a dog’s bodyweight to the application sites.

Cats come in all loveable shapes and sizes. Follow the diagram below and apply the contents of the appropriate tube for a cat’s bodyweight to the application sites.

Apply at the base of the skull, to ensure the wet product can’t be licked.

For cats <6.25 kg, apply in one spot.

For cats >6.25 kg, apply in two spots.

HOW TO APPLY BRAVECTO SPOT-ONBravecto comes with a clever TWIST’N’USE tube with a non-removable cap.

Remove Bravecto from its child-safe packaging.

Hold the tube straight up, and give the cap one twist to break the seal.PLEASE DO NOT ATTEMPT TO REMOVE THE CAP AS IT DOES NOT COME OFF.

Ensure the animal’s back is horizontal. Part the hair and apply directly to the skin.

HO

W T

O D

OSE

12

Bravecto Chew and Bravecto Spot-On for Dogs should be used in dogs from 8 weeks of age, weighing at least 2 kg. For dogs above 56 kg, use a combination of two Bravecto chews or two tubes that most closely matches the body weight.

BODY WEIGHT OF DOG (KG)

BRAVECTO VERY SMALL

DOG

BRAVECTO SMALL

DOG

BRAVECTO MEDIUM

DOG

BRAVECTO LARGE DOG

BRAVECTO VERY LARGE

DOG

2 – 4.5 1 chew or tube

>4.5 – 10 1 chew or tube

>10 – 20 1 chew or tube



SIMPLE, CONVENIENT DOSING

BODY WEIGHT OF CAT (KG)

BRAVECTO OR BRAVECTO PLUS

SMALL CAT


MEDIUM CAT


LARGE CAT

1.2 – 2.8 1 tube

>2.8 – 6.25 1 tube

>6.25 – 12.5 1 tube

Bravecto Spot-on and Bravecto Plus for Cats is for use in cats from 9 weeks of age, weighing at least 1.2 kg. For cats above 12.5 kg, use a combination of two tubes that most closely matches the body weight.

^Control of FAD.*It is not recommended to wash or allow the dog to become immersed or swim in water within 3 days after treatment. +All-in-one treatment for fleas, paralysis ticks, heartworm, roundworm, hookworm and ear mites. Refer to product label for full claim details.

BRAVECTO CHEW

FOR DOGS

BRAVECTO SPOT-ON

FOR DOGS

BRAVECTO SPOT-ON FOR CATS

BRAVECTO PLUS

FOR CATS

Recommended treatment interval

Treat every 3 months

for fleas and paralysis ticks






for all-in-one+ cover

Fleas 3 months 6 months Up to 3 months 3 months

Paralysis tick 4 months 6 months 3 months 10 weeks

Brown dog tick 2 months 12 weeks

Bush tick 2 months

Heartworm 2 months

Roundworm ✔

Hookworm ✔

Otodectes – ear mite ✔ ✔ ✔ ✔

Sarcoptes – mange mite ✔ ✔

Demodex – mange mite ✔ ✔

Flea tapeworm ✔ ✔

Highly effective against fipronil resistant fleas ✔ ✔ ✔ ✔

Reduces incidence of Flea Allergy Dermatitis

(FAD) ✔

^ ✔

^✔ ✔

One dose lasts the full flea life cycle ✔ ✔ ✔ ✔

Safe for use in breeding, pregnancy and lactation ✔ ✔

Safety not established

Safety not established

Safe for use in MDR1 breeds ✔ ✔ Not applicable Not applicable

Suitable for swimming ✔ ✔ *

Start age and weight From 8 weeks and 2 kg From 8 weeks and 2 kg From 9 weeks and 1.2 kg From 9 weeks and 1.2 kg

14

References: 1. Project Orbit Dog and Cat Market Research Study, MSD Animal Health, 2019 2. Crkvencic, N & Slapeta, J., 2019. Climate change models predict southerly shift of the cat flea (Ctenocephalides felis) distribution in Australia. Parasites & Vectors 12:137. 3. Ross DH, Arthur, et al., 2015. Evaluation of the efficacy of topically administered imidacloprid + pyriproxyfen and orally administered Spinosad against cat fleas (Ctenocephalides felis): Impact of treated dogs on flea life stages in a simulated home environment. Parasites & Vectors 5:192. 4. Williams, H. et al., 2014. Fluralaner, a novel isoxazoline, prevents flea (Ctenocephalides felis) reproduction in vitro and in a simulated home environment. Parasites & Vectors 7:275. 5. Atwell RB, Campbell FE, Evans EA., 2011. Prospective survey of tick paralysis in dogs. Australian Veterinary Journal 79:412-418. 6. Webster MC et al., 2011. Long-term efficacy of a deltamethrin-impregnated collar for the control of the Australian paralysis tick, Ixodes holocyclus, on dogs. Australian Veterinary Journal 89:11. 7. Fisara P. & Webster, M., 2015. A randomised controlled trial of the efficacy of orally administered fluralaner Bravecto™ against induced Ixodes holocyclus (Australian paralysis tick) infestations on dogs. Parasites & Vectors 8:257. 8. Fisara, P., Guerino, F. & Sun, F., 2018. Investigation of the efficacy of fluralaner spot-on Bravecto® against infestation of Ixodes holocyclus on cats. Parasites & Vectors 11:366. 9. MSD data on file. 2015. Paralysis tick study in dogs. 15:0017. 10. MSD data on file. MSFF1122. 11. Chandra, S. et al., 2020. The brown dog tick Rhipicephalus sanguineus sensu Robers, 1965 across Australia: Morphological and molecular identification of R. sanguineus s.l. tropical. Ticks and Tick-Borne Diseases. 11:1. 12. Dantes-Torres, F., 2010. Biology and ecology of the brown dog tick, Rhipicephalus sanguineus. Parasites & Vectors 3:26. 13. Hii et al., 2015. Canine tick-borne pathogens and associated risk factors in dogs presenting with and without clinical signs consistent with tick-borne disease in Northern Australia. Australian Veterinary Journal. 93:3. 14. MSD Data on file. Brown dog tick study in dogs. 2012; V-0084-0107. 15. Dryden, MW., 2020, Mange in Dogs and Cats. Merck Veterinary Manual: http://www.merckvetmanual.com/integumentary-system/mange/mange-in-dogs-and-cats. 16. Palmer, C.S. et al., 2008. National study of the gastrointestinal parasites of dogs and cats in Australia. Veterinary Parasitology 151, 181–190. 17. Brown, G. et al. 2014. Australian Animal Parasites Inside & Out. The Australian Society for Parasitology Inc. file:///C:/Users/fenns/Downloads/Parasitology2015.pdf 18. Litster, A.L. & Atwell, R.B., 2008. Feline Heartworm disease: A clinical review. Journal of Feline medicine and Surgery 10, 137 – 144. 19. Executive Board of the American heartworm Society, 2014. Summary of the Current Feline Guidelines for the Prevention, Diagnosis, and Management of Heartworm (Dirofilaria immitis) infection in Cats. https://www.heartwormsociety.org/images/pdf/2014-AHS-Feline-Guidelines.pdf 20. Taenzler J. et al., 2014. Onset of activity of fluralaner Bravecto® against Ctenocephalides felis on dogs. Parasites & Vectors 7:567. 21. Gopinath et al., 2018. Topical or oral fluralaner efficacy against flea (Ctenocephalides felis) transmission of Dipylidium caninum infection to dogs. Parasites & Vectors 11:557. 22. Walther FM Allan AJ, Allam MJ et al., 2014. Safety of fluralaner, a novel systemic antiparasitic drug, in MDR1(-/-) Collies after oral administration. Parasites & Vectors 7:86. 23. Bravecto chewable for Dogs product label. 24. Bravecto Spot-on for Dogs product label. 25. MSD data on file Speed of kill for fleas in cats. 2013. V-0084-0198. 26. Bravecto Spot-on for Cats product label. 27. Taenzler et al (2017) Efficacy of fluralaner against Otodectes cynotis infestations in dogs and cats. Parasites & Vectors.10:30. 28. Bravecto Plus product label. 29. MSD data on file, study FCC504 and study MSFC/1112. 30. Rohdich N et al., 2018. A randomized, blinded, controlled, multi-centered field study assessing the treatment of gastrointestinal nematode infections in cats with fluralaner plus moxidectin spot-on solution Bravecto®. Parasites & Vectors 11:589. 31. MSD data on file, study S13343-00. 32. Walther, Allan et al. Safety of fluralaner chewable tablets Bravecto™, a novel systemic antiparasitic drug, in dogs after oral administration. Parasites & Vectors (2014) 7:87. 33. MSD data on file. Margin of safety study in cats. 2013; V-0084-014 & V-0084-0289. 34. MSD data on file. Margin of safety study in dogs V-0084-0139 & V-0084-0288. 35. MSD data on file, study S14345-00.

© 2020 Intervet International B.V. All Rights Reserved. MSD Animal Health. ABN 79 008 467 034. Toll free: 1800 230 833. AU/BRV/0320/0012.

We’re here to help!Contact your MSD Animal Health

Representative about our Bravecto Range, or call the Bravecto Hotline on 1800 230 833.

[email protected]

www.bravecto.com.au

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Documents

Long-lasting parasite protection for dogs and cats · fortnightly treatments require diligent reapplication. The majority of pet owners only treat for fleas and ticks every 3 months