Look Closer.

It’s an original. To receive your

FREE copy of the 2007-2008 Catalog,

go to sigma.com/antibodycat.

sigma-aldrich.com

Look closer. Over 4,000 antibodies backed by a no-risk trial program.

Validated, characterized, high-quality antibodies — each meeting

rigorous application testing and documented by reproducible data.

See for yourself. With Sigma’s Your Favorite Gene™ online search

tools, you can match your gene of interest against thousands of

antibodies and other Sigma research products.

Look even closer. Go to sigma.com/lookcloser for more information

and to enter our origami contest!

Our Innovation, Your Research — Shaping the Future of Life Science

Antibodies that work,right out of the box!

Your Favorite Gene is a trademark of Sigma-Aldrich Co., and its affiliate Sigma-Aldrich Biotechnology, L.P.

cell sciences

PROTEINS4-1BBL

4-1BB Receptor

6 Ckine

ACAD8ACAT2

gAcrp30/Adipolean

Activin AActivin B

ACY1

ADAT1

AdiponectinADRPAITRL

Akt1

Alpha-Feto Protein (AFP)

Alpha-Galactosidase AAngiopoietin-1 (Ang-1)Angiopoietin-2 (Ang-2)

Angiostatin K1-3

Annexin-V

apo-SAAApoliprotein A-1Apoliprotein E2

Apoliprotein E3

Apoliprotein E4

APRILArteminATF2

Aurora AAurora B

BAFFBAFF ReceptorBCA-1 / BLC / CXCL13

BCMABD-1

BD-2BD-3BDNF

Betacellulin

Bivalirudin

BMP-2BMP-4

BMP-6BMP-7

BMP-13sBMPR-1A

Brain Natriuretic Protein

BRAKBreast Tumor Antigen

C5aC5L2 Peptide

C-10

C-Reactive ProteinC-Src

Calbindin D-9KCalbindin D-28K

Calbindin D-29K

CalmodulinCalcitonin Acetate

Carbonic Anhydrase III

Carcino-embryonic Antigen

Cardiotrophin-1Caspase-3

Caspase-6

CD4

CD14

CD22CD40 Ligand / TRAP

ww

w.c

ellscie

nces.c

om

ww

w.c

ellscie

nces.c

om

www.CytokineCenter.com

480 Neponset Street, Building 12A, Canton, MA 02021 • TEL (781) 828-0610 • EMAIL info@cellsciences.com

CALL TOLL FREE (888) 769-1246 • FAX (781) 828-0542 • VISIT www.cellsciences.com

CD95 / sFas Ligand

CD105 / Endoglin

CHIPSCNTF

Collagen

CREB

CTACK / CCL27CTGF

CTGFL / WISP-2CTLA-4 / Fc

CXCL16

CYR61Cytokeratin 8

DEP-1Desmopressin

Disulfide Oxidoreductase

E-selectinECGF

EGFElafin / SKALP

EMAP-II

ENA-78 / CXCL5Endostatin

EnteropeptidaseEotaxin / CCL11

Eotaxin-2

Eotaxin-3 (TSC)EPHB2

EPHB4Epigen

Epiregulin

EptifbatideErk-2

Erythropoietin (EPO)Exodus-2

Fas Ligand

Fas ReceptorFGF-1 (acidic)

FGF-2 (basic)FGF-4

FGF-5

FGF-6FGF-7 / KGFFGF-8

FGF-9

FGF-10

FGF-16FGF-17

FGF-18

FGF-19

FGF-20

sFGFR-1 (IIIc) / Fc ChimerasFGFR-2 (IIIc) / Fc Chimera

sFGFR-3 / Fc Chimera

sFGFR-4 / Fc Chimera

sFlt-1 (native)

sFlt-1 (D3)sFlt-1 (D4)

sFlt-1 (D5)

sFlt-1 (D7)

Flt3-Ligand

sFlt-4

sFlt-4 / Fc Chimera

FollistatinFSH

Fractalkine / CX3C

G-CSF

α-Galactosidase A

Galectin-1

Galectin-3

Gastrointestinal CA

GCP-2GDF-3

GDF-9

GDF-11

GDNF

GLP-1Glucagon

GM-CSF

GoserelinGPBB

Granzyme BGROα

GROβ

GROγ

GRO/MGSA

Growth HormoneGrowth Hormone BP

GST-p21/WAF-1

HB-EGFHCC-1

HGFHistdyl-tRNA synthetase

Histrelin

HRG1-β1I-309

I-TACIFN-α

IFN-α A

IFN-α 2aIFN-α 2b

IFN-βIFN-γ

IFN-Omega

IGF-IIGF-II

proIGF-IIIGFBP-1

IGFBP-2

IGFBP-3

IGFBP-4

IGFBP-5IGFBP-6IGFBP-7

IL-1α

IL-1β

IL-2

IL-3IL-4

sIL-4 Receptor

IL-5

IL-6

sIL-6 ReceptorIL-7

IL-8 (72 a.a.)

IL-8 (77 a.a.)IL-9

IL-10IL-11

IL-12IL-13

IL-13 analog

IL-15IL-16 (121 a.a.)

IL-16 (130 a.a.)

IL-17

IL-17B

IL-17D

Cytokine CenterBrowse our web site with over 1300 proteins,

including recombinant cytokines, growth

factors, chemokines and neurotrophins. Daily

shipping and competitive pricing are offered.

Bulk quantities of many proteins available.

IL-17E

IL-17FIL-19

IL-20

IL-21

IL-22

IL-31Insulin

IP-10

JE

JNK2a1

JNK2a2KC / CXCL1

KGF

L-asparaginase

LAG-1

LALF PeptideLAR-PTP

LBP

LC-1LD-78β

LDH

LEC / NCC-4Leptin

LIGHTLIX

LKM

LL-37Lungkine / CXCL15

LymphotactinsLYVE-1

M-CSF

MCP-1 (MCAF)MCP-2

MCP-3

MCP-4

MCP-5MDC (67 a.a.)

MDC (69 a.a.)

MDHMEC

Mek-1MIA

Midkine

MIG / CXCL9MIP-1α / CCL3

MIP-1β / CCL4MIP-3 / CCL23

MIP-3α / CCL20

MIP-3β / CCL19MIP-4 (PARC) / CCL18

MIP-5 / CCL15MMP-3

MMP-7

MMP-13

Myostatin

Nanog

NAP-2Neurturin

NFAT-1

β-NGF

NOGGIN

NOVNP-1

NT-1/BCSF-3

NT-3

NT-4

OcreotideOncostatin M

Osteoprotegerin (OPG)

OTOROxytocin

p38-αPAI-1Parathyroid Hormone

PDGF-AA

PDGF-ABPDGF-BB

PDGF-CC

Persephin

PF-4

PIGF-1

PIGF-2

PKA α-subunit

PKC-α

PKC-γPleiotrophin

PLGF-1

Polymyxin B (PMB)

PRAS40

PRL-1PRL-2

PRL-3

Prokineticin-2

Prolactin

ProtirelinPTHrP

PTP1B

PTP-IA2PTP-MEG2

PTP-PEST

sRANK

sRANKL

RANTESRELM-α

RELM-β

ResistinRPTPβ

RPTPγRPTPμ

SCF

SCGF-αSCGF-β

SDF-1αSDF-1β

Secretin

SF20SHP-2

STAT1c-Src

TACI

TARCTC-PTP

TECKTFF2

TGF-α

TGF-β1TGF-β2

TGF-β3Thymosin α1

sTIE-1/Fc Chimera

sTIE-2/Fc Chimera

TL-1A

TNF-αTNF-β

sTNF-receptor Type I

sTNF-receptor Type II

TPO

sTRAIL R-1 (DR4)

sTRAIL R-2 (DR5)TRAIL/Apo2L

TSG

TSH

TSLP

TWEAKTWEAK Receptor

Urokinase

EG-VEGF

VEGF121

VEGF145VEGF165

VEGF-C

VEGF-C I125VEGF-E

HB-VEGF-EsVEGFR-1

sVEGFR-2

sVEGFR-3

Visfatin

WISP-1

WISP-2WISP-3

WNT-1

®®

GE Healthcare

When it comes to life sciences, GE Healthcare is setting the

standard. Tens of thousands of scientists in over 100 countries

around the world rely on our products every day. We have

delivered more than 60 000 research protein purification systems,

1500 BioProcess™ systems and 12 000 BioProcess columns

worldwide. Our Amersham family of consumables, with its 60-year

heritage, is trusted to provide accurate results time and time again.

But we’re never content to stand still. We constantly strive for

new innovations for tomorrow’s research and drug development.

And the result is groundbreaking products like the ÄKTAdesign™

platform, IN Cell Analyzer, Ad-A-Gene Vectors, and MabSelect™

media. Thanks to our technological achievements and global

presence, we’re able to help you turn your scientific ideas into

reality – bringing science to life and helping transform healthcare.

We call it Life Science Re-imagined.

Discover more at www.gelifesciences.com

Bringingscience to life

GE

He

alt

hca

reB

io-S

cie

nce

sA

B,a

Ge

ne

ralE

lect

ric

Co

mp

an

y.B

jörk

ga

tan

30

,75

18

4U

pp

sala

,Sw

ed

en

.©

20

07

Ge

ne

ralE

lect

ric

Co

mp

an

y-

All

rig

hts

rese

rve

d.

GE

34

-07

2008 AAAS Annual Meeting14–18 February 2008 • Hynes Convention Center, Boston

Get Involved in a Global ConversationCome to one of the most cross-disciplinary conferences in the world. Engage in powerful

networking opportunities while gaining new insights. Hear and discuss the latest advances

in scientific research and technology.

Network. Connect. Learn.

Sessions emphasize the power of science, technology, and engi-

neering as well as education to assist less-developed segments

of the world society, to improve partnerships among already-

developed countries, and to spur knowledge-driven transforma-

tions across a host of fields.

Each year at the AAAS Annual Meeting, professionals from

across disciplines and around the world gather to discuss new

research, emerging trends, and exciting new possibilities.

It’s the place to be from 14–18 February for scientists and

engineers with a passion for their work or a desire to meet the

world’s foremost experts.

> Stimulating Plenary and Topical Lectures

> Hundreds of Distinguished Speakers

> Cutting-Edge Symposia

> Two-Day Marine Seminar

> Town Hall

> Specialized Career-Building Workshops

> Science Career Fair

> International Exhibit Hall

> Family Science Days

To find out more, go to www.aaas.org/meetings

and select Program.

Visit www.aaasmeetings.org

and select > Register

Meeting Registration is open to all. If you have colleagues who want to join AAAS, tell themabout this offer before it expires. Register in advance for the 2008 Annual Meeting and receive a one-year

membership along with all benefits. These include a one-year subscription to the journal Science and online

access to Science, including archives back to 1880. This special membership offer expires on 18 January 2008.

Only nonmembers qualify.

Register Now: Get special discounts on meeting and hotel registration. All advance registrants will be eligible to winround-trip airfare to and from the Meeting. Register by 18 January 2008.

www.sciencemag.org/products SCIENCE VOL 319 4 JANUARY 2008 107

New Products

LIFE SCIENCE TECHNOLOGIESAAAS/Science Business Office Feature

Debubbler SeriesThe Systec Debubbler Series for low-pressure diagnostic andlife science instruments improves on passive bubble-trap tech-nology with active bubble removal and transfer-line degassing.Three configurations—active debubbler, degasser/debubbler,or transfer-line degasser—offer the choice of removing bubbleswith or without also removing dissolved system gases. Highly ef-ficient online active debubbling helps equipment manufacturersimprove dispensing precision, reduce sample loss and reagentusage, and improve analytical accuracy in high throughput ap-plications. The new series features an innovative semipermeabledegassing membrane to remove gases from dispensed liquids.

Gel Documentation SystemThe next generation DigiGenius budget gel documentation systemfeatures a high-resolution, computer-controlled camera, allowingmolecular biologists to easily view images in real time on any com-puter. The 10-megapixel camera can separate even the closest bandimages. The camera can be linked via an interface to a computer inorder to automate the camera’s setup and images can be capturedon either a flash card or computer. Users can choose to add compat-ible components to the basic system such as an ultraviolet transil-luminator or white or blue conversion screens. It comes with a safetyhood upgradeable to a full minidarkroom.Syngene

For information 800-686-4407www.syngene.com

Sulfur-Compound MeasurementA sensitive new analytical system enables routine measurementof thiols, thioesters, disulfides, and other sulfur-containing com-pounds. Sulfur-containing compounds are critical to a variety ofbiologically and clinically important processes, from oxidative me-tabolism, to cardiovascular and neurodegenerative-disease mecha-nisms, to signal transduction, butmeasuring themhas been difficult.The new system incorporates a specially developed electrochemicalcell with a unique boron-doped diamond (BDD) working electrodecoupled with the Coulochem III ECD system. The electrode providesexcellent sensitivity and durability, while eliminating the problemsof fouling, high background, and mobile phase oxidation associatedwith earlier electrochemical detection (ECD) systems.ESA Analytical

For information +44 1844-239381www.esainc.com

LiteraturePrecision Optical Filters for FluorescenceMicroscopy is a new catalogthat includes 15 new high-performance sets for fluorescent proteinsand 10 new sets for fluorescence resonance energy transfer. Thesenew products complement an extensive selection of dye-specific fil-ter sets for all single-label and multilabel microscopy applications,including quantum dots, multiplex fluorescence in situ hybridization,ratio imaging, confocal, and multiphoton. Other resources include afluorophore reference table, light source and detector spectral data,an explanation of filter nomenclature, guidelines for choosing the op-timal filter sets, and a list of components organized by wavelength.Omega Optical

For information 802-254-2690www.omegafilters.com

Distillation SystemThe Lab-Crest Midi-Dist Distillation System saves space and timein laboratory testing and analysis requiring distillation. Designedto allow replacement of costly macro distillation techniques, thesecompact units allow multiple samples to be prepared for analysisquickly and easily. The heater, holder, manifolds, tubing, couplings,and controls are integrated and designed to simplify setup and use.It is comprised of 10 complete borosilicate glass units and a 10-position aluminum heat block and apparatus holder, coated withTeflon for corrosion resistance. Glassware, heater, water, and vacuummanifolds, controls, and connections are integrated into a singlecompact system. The system can handle up to 10 50-ml liquid orsludge samples.Andrews Glass Co.

For information 800-845-0026www.andrews-glass.com

Multiparameter SystemVersion 2.0 of the LiQC multiparameter system is for simultaneousdetermination of density, refractive index, pH/conductivity, and color.The instrument combines single measurements into one automatedprocess. A sample vial is filled, placed on an automatic sample chang-er, and assigned a barcode label. The LiQC automatically completesevery subsequent step: choosing the appropriate method, pumpingthe sample into the various flow-through cells, and performing allmeasurements. The instrument evaluates results statistically, com-pares them to specifications, and transfers them to laboratory infor-mation systems. The LiQC thoroughly cleans and dries the measuringcells before moving on to the next sample.Mettler Toledo

For information 614-438-4505www.mt.com

IDEX Health & Science

For information 360-679-2528www.idex-hs.com

Newly offered instrumentation, apparatus, and laboratory materials

of interest to researchers in all disciplines in academic, industrial, and

governmental organizations are featured in this space. Emphasis is

given to purpose, chief characteristics, and availabilty of products and

materials. Endorsement by Science or AAAS of any products or materials

mentioned is not implied. Additional informationmay be obtained from the

manufacturer or supplier.

New Products

FREE Drug Development Resources for the

Academic/Not-for-Profit Investigator

On a competitive basis, the NIH offers certain critical

resources needed for the development of new small

molecule therapeutic agents. The NIH-RAID Pilot is

not a grant program. Successful projects will gain

access to the government’s contract resources. Services

include: Synthesis in bulk of small molecules;

Synthesis of oligonucleotides; Chemical synthesis of

peptides; Scale-up production; Development of

analytical methods; Isolation and purification of natural

products; Pharmacokinetic/ADME studies including

bioanalytical method development; Development of

suitable formulations; Manufacture of clinical trial drug

supplies; Range-finding initial toxicology; IND-

directed toxicology; Product development planning and

advice in IND preparation. The program also is open to

non-U.S. applicants.

Applications are received electronically through

Grants.gov. Ideas arising solely from a corporate source

without academic collaborators are not eligible.

NIH-RAID Pilot Program Office

301-594-4660; nih-raid@mail.nih.gov

URL: http://nihroadmap.nih.gov/raid

National Institutes of HealthRapid Access to Interventional Development

2008 NASA Space Radiation Summer School

Applications are being sought for the 2008 NASA Space RadiationSummer School, a three-week course designed to offer graduatestudents, postdoctoral fellows, and faculty an integrated curriculum ofradiation biology, radiation chemistry, and physics culminating in hands-onaccelerator-based experiments using the synchrotron facility at the NASA

Space Radiation Laboratory. Up to 15 students will be selected for thecourse to be held May 28 – June 20, 2008 at the Brookhaven NationalLaboratory (BNL) on Long Island, New York. Topics will include DNA

damage and repair, genotoxicity measurements, cell cycle checkpointsand apoptosis, the bystander effect, genomic instability,

neurodegeneration, tissue remodeling, and the relationships of theseprocesses to carcinogenesis and late degenerative effects followingexposure to space radiation, as well as the space radiation environment,physics and biochemistry of charged particle interaction with condensed

matter, ionizing radiation dosimetry, and accelerator operations. Coursefaculty consists of leading university and national laboratory biologists and

physicists actively engaged in NASA space radiation research and BNL

experts in heavy ion experimentation and methods.

Application instructions may be found atwww.dsls.usra.edu/spacerad/2008/

The Application Deadline is 5:00 p.m. CT, February 28, 2008. U.S.citizens and foreign nationals may apply. All selected students mustsatisfy BNL/DOE safety and security requirements in order to be admitted.Selected students must demonstrate oral and written proficiency in theEnglish language. Travel expenses in the U.S. and room and board willbe covered for selected participants. Successful applicants from outsidethe U.S. must provide for their travel to/from New York/Long Island.Course sponsors are the NASA Space Radiation Project, BrookhavenNational Laboratory, Lawrence Berkeley National Laboratory, and theUniversities Space Research Association.

MyCube by Antarus

Biotech is a powerful

Personal Thermal Cycler

designed for simplicity

and operated by

intuitive software that

provides comprehensive

run logs for detailed

documentation.

Huntsville, Alabama

genomic research • economic development • educational outreach • hudsonalpha.org

HudsonAlpha salutes Antarus Biotech, one of our first Resident Associates

where biotech begins

(actual size)

1. Cut along dotted line

2. Place on workspace

3. Admire streamlined fit

(At only $990 MyCubecan fit your budget too)

Personal

Thermal Cycler

$990Directions: