Luke the Limping Labrador

Linden Craig, DVM, PhD, DACVP

Presented at SEVPAC 2008 – Permission granted for use on

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Signalment

• 10 year old • Intact male• Black Labrador retriever

Presented at SEVPAC 2008 – Permission granted for use on

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Clinical History

• One year duration• Swelling and lameness• Left stifle

Presented at SEVPAC 2008 – Permission granted for use on

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Luke at UT

• Painful swollen stifle• FNA – viscous fluid

Presented at SEVPAC 2008 – Permission granted for use on

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UT Radiographs

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Biopsy

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Diagnosis?

Synovial myxomaBenign, slow

growingNodular morphology

Presented at SEVPAC 2008 – Permission granted for use on

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Synovial Myxoma

1. Adult Doberman – stiflesynovectomy curative

2. 16 yr old Doberman – stifleamputation curative

3. 9 yr old English spaniel – C2 & C3incidental finding at

necropsy

Tumors in Domestic Animals 4th ed, DJ Meuten Ed, 2002, p. 213Presented at SEVPAC 2008 – Permission granted for use on

SEVPAC website only

Synovial Myxoma

1. Labrador retriever – tarsus

2. Miniature poodle – stifle

3. Doberman cross – carpus

4. Doberman cross – stifle

5. Doberman – carpus6. Doberman – stifle

doxorubicin died

The diagnosis and prognosis of synovial tumors in dogs: 35 cases Vet Path 39:66-73, 2002

Presented at SEVPAC 2008 – Permission granted for use on

SEVPAC website only

Presented at SEVPAC 2008 – Permission granted for use on

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Luke’s Leg

Presented at SEVPAC 2008 – Permission granted for use on

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07-3354

Presented at SEVPAC 2008 – Permission granted for use on

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Synovial Myxoma

Presented at SEVPAC 2008 – Permission granted for use on

SEVPAC website only

Presented at SEVPAC 2008 – Permission granted for use on

SEVPAC website only

Presented at SEVPAC 2008 – Permission granted for use on

SEVPAC website only

Invasion into bone

Presented at SEVPAC 2008 – Permission granted for use on

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Presented at SEVPAC 2008 – Permission granted for use on

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Synovium

Presented at SEVPAC 2008 – Permission granted for use on

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Synoviocytes

Secrete synovial fluid

Dendritic cells

+ Type C synoviocyte

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Synoviocytes

H&E

CD18Presented at SEVPAC 2008 – Permission granted for use on

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Synoviocytes tumors(Craig Hypothesis)

• Type A – Dendritic cell– Histiocytic sarcoma

• Type B – Secretes synovial fluid– Synovial myxoma

• Type C – Transitional or stem cell– Synovial cell sarcoma

Presented at SEVPAC 2008 – Permission granted for use on

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Synovial Tumors - Survival

The diagnosis and prognosis of synovial tumors in dogs: 35 cases Vet Path 39:66-73, 2002

Presented at SEVPAC 2008 – Permission granted for use on

SEVPAC website only

Synovial Myxoma Summary

• Slow growing• Nodular• Benign

Presented at SEVPAC 2008 – Permission granted for use on

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