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LVI TechnoLogy• LVIcatheterenablesreal-time,three-dimensional(4D)
visualizationforintracardiacsurgeries
• Providesinstantaneous, full-volume viewsatthepointofsurgery,withgreaterfield-of-viewandcontinuousimagingofthedynamicanatomicenvironment
• Existingintracardiacecho(ICE)cathetersproduceonlytwo-dimensionalimages,limitingsurgeon’sfield-of-view
enVIsIoned AppLIcATIon• Pulmonaryveinablation
• Atrialfibrillationaffectsover5millionpeople
• 75,000proceduresperyearinU.S.
• Failurerate>30%dueinparttoinadequateimageguidance,leadingtounderablation
• LVIcanpotentiallyincrease efficacybyprovidingacontinuousintracardiacviewofthecathetertip
• LVIcanpotentiallyreduce injurybyprovidingbetter,continuousviewsofadjacentanatomy
BreAkThrough TrAnsducer TechnoLogy• MEMS-basedMatrixPhasedArraytransducer
– 256-512elementsfor4Dimaging
– Semiconductorprocessingformanufacturabilityandminiaturization
– Nocuttingandassemblyofpiezoceramicplates
– Transducerarraysproducedinbatchesofsiliconwafers
• Novelcableassembliesintegratedusingsemiconductorpackagingandinterconnectiontechnologies
recenT progress• Demonstratedreal-time3Dimagingfrom5to12.5MHz,ideallysuitedfor
intracardiacimaging
• Fabricatedoperational14Fintracardiaccatheterprototypesandcompletedinitialin vivoanimalimagingexperiments
LVI Performance Meets User Needs
Technology LVI ICE Mechanical 4D ICE1 3D TEE2
Volume sector60° x 60°
(up to 80° x 80°)60° x 90°
60° x 60° (up to 90° x 90°)
Scan depth 8-10 cm 6 cm >10 cm
Frame rate 25-30 vol/s 6 vol/s 7-10 vol/s
Resolution1 mm
(40 mm depth)good good
Transducer cost $ $$ $$$1 Lee et al. (2010) Proc. IEEE IUS: 8332 Faletra et al. (2012) Circ. J. 76:5
expecTed BenefITs• Fewer complications—Improvedvisibilityofmovinganatomy
• Efficient imaging—Real-timedatacapture,full-volumeviewsthatcanbemanipulatedtochangevantagepoint
• More patients—Reducedprocedure/examtime
• Better outcomes—Shorter,moreaccurateprocedures
Ice cATheTer proToType• Real-time,volumetricimaging
• Matrixphasedarray
• 14F,side-looking
• 5MHz
• Steerable
• 35”workinglength
referencesD.E.Dausch,J.B.Castellucci,K.H.Gilchrist,J.R.Carlson,D.R.Chou,
andO.T.vonRamm,2010.“ImprovedPulse-EchoImagingPerformanceforFlexure-ModepMUTArrays,”Proc.IEEE Ultrasonics Symposium:451-454
D.E.Dausch,J.B.Castellucci,D.R.Chou,andO.T.vonRamm,2008.“TheoryandOperationof2DArrayPiezoelectricMicromachinedUltrasoundTransducers,”IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 55(11):2484–2492
U.S.Patent7,449,821,US2010/0168583,WO2011/094393,WO2011/139602
AcknowLedgmenTTheauthorsthankProfessorOlafvonRammandMr.JohnCastellucciofDukeUniversityfortheirassistanceindevicetestingandreal-time3Dultrasoundimaging.
more InformATIonDavidE.Dausch,PhD LynnM.Soby,PhDSeniorResearchEngineer V.P.,Commercialization919.248.1412 [email protected] [email protected]
RTI International3040CornwallisRd.,ResearchTrianglePark,NC27709
See the difference.
Live Volumetric Imaging (LVI) Catheter for Intracardiac Echo (ICE)David E. Dausch, PhD, Lynn M. Soby, PhD • RTI International, Research Triangle Park, NC
Concept for live volumetric image guidance during intracardiac pulmonary vein ablation
RTIInternationalisatradenameofResearchTriangleInstitute.
Real-time volume scan of a metal spring and finger tips in a water tank using a 512-element pMUT matrix phased array (60° x 60° volume, 3 mm x 6 mm array, 5.6 MHz)
Matrix Phased Array Piezoelectric Micromachined Ultrasound Transducer (pMUT) integrated with catheter cable assembly
LVI Prototype ICE Catheter
February,2013
BestSufficientPoor