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Volume 8, Number 5, September 2021Neurology.org/NN
A peer-reviewed clinical and translational neurology open access journal
ARTICLE
Encephalopathies Associated With Severe COVID-19 Present Neurovascular Unit Alterations Without Evidence for Strong Neuroinfl ammation e1029
ARTICLE
Autoimmune Encephalitis Resembling Dementia Syndromes e1039
ARTICLE
International Consensus Recommendations for the Treatment of Pediatric NMDAR Antibody Encephalitis e1052
ARTICLE
COVID-19 in Patients With Neuromyelitis Optica Spectrum Disorders and Myelin Oligodendrocyte Glycoprotein Antibody Disease in North America: From the COViMS Registry e1057
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A peer-reviewed clinical and translational neurology open access journal Neurology.org/NN
Neurology® Neuroimmunology & Neuroinflammation
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TABLE OF CONTENTS Volume 8, Number 5, September 2021 Neurology.org/NN
Editorial
e1054Combined Neurofilament Light and OpticalCoherence Tomography Better PredictsMultiple Sclerosis Disease Activity Than EitherMeasure AloneJ. Kramer, H. Wiendl, S.G. Meuth, and P. Albrecht
Open Access
Articles
e1028 Antiplexin D1 Antibodies Relate to SmallFiber Neuropathy and Induce Neuropathic Painin AnimalsT. Fujii, E.-J. Lee, Y. Miyachi, R. Yamasaki, Y.-M. Lim, K. Iinuma,A. Sakoda, K.-K. Kim, and J.-i. Kira
Open Access
e1027Differential Binding of Autoantibodies toMOG Isoforms in Inflammatory DemyelinatingDiseasesK. Schanda, P. Peschl, M. Lerch, B. Seebacher, S. Mindorf, N. Ritter,M. Probst, H. Hegen, F. Di Pauli, E.-M. Wendel, C. Lechner,M. Baumann, S. Mariotto, S. Ferrari, A. Saiz, M. Farrell, M.I.S. Leite,S.R. Irani, J. Palace, A. Lutterotti, T. Kumpfel, S. Vukusic, R.Marignier,P. Waters, K. Rostasy, T. Berger, C. Probst, R. Hoftberger, andM. Reindl
Open Access
e1022Nodular Pachymeningitis Associated With RelapsingPolychondritis and Crohn Disease Responsive toAdalimumab and PrednisoneS.K. Hutto, M.D. Maher, E.M. Miloslavsky, and N. Venna
Open Access
e1029 Encephalopathies Associated With Severe COVID-19Present Neurovascular Unit Alterations WithoutEvidence for Strong NeuroinflammationR. Bernard-Valnet, S. Perriot, M. Canales, B. Pizzarotti, L. Caranzano,M. Castro-Jimenez, J.-B. Epiney, S. Vijiala, P. Salvioni-Chiabotti,A. Anichini, A. Salerno, K. Jaton, J. Vaucher, M. Perreau, G. Greub,G. Pantaleo, and R.A. Du Pasquier
Open Access
e1030 Effects of Natalizumab Therapy on IntrathecalImmunoglobulin G Production Indicate Targetingof PlasmablastsM. Schluter, E. Oswald, S. Winklmeier, I. Meinl, J. Havla, P. Eichhorn,E. Meinl, and T. Kumpfel
Open Access
e1031 Interleukin 8, a Biomarker to DifferentiateGuillain-Barre Syndrome From CIDPG.Breville,A.M.Lascano,P.Roux-Lombard,N.Vuilleumier,andP.H.Lalive
Open Access
e1032 Argonaute Autoantibodies as Biomarkers inAutoimmune Neurologic DiseasesL.-D.Do,C.P.Moritz, S.Muñiz-Castrillo,A.-L.Pinto,Y. Tholance,S.Brugiere,Y.Coute,O. Stoevesandt,M.J. Taussig, V.Rogemond,A.Vogrig,B. Joubert,K. Ferraud, J.-P. Camdessanche, J.-C. Antoine, and J. Honnorat
Open Access
e1034Molecular Level Characterization of CirculatingAquaporin-4 Antibodies in Neuromyelitis OpticaSpectrum DisorderJ. Li, S.A.Bazzi, F.Schmitz,H.Tanno, J.R.McDaniel,C.-H.Lee,C. Joshi, J.E.Kim,N. Monson, B.M. Greenberg, K. Hedfalk, E. Melamed, and G.C. Ippolito
Open Access
e1035Ocrelizumab Extended Interval Dosing in MultipleSclerosis in Times of COVID-19L. Rolfes, M. Pawlitzki, S. Pfeuffer, C. Nelke, A. Lux, R. Pul,C. Kleinschnitz, K. Kleinschnitz, R. Rogall, K. Pape, S. Bittner, F. Zipp,C. Warnke, Y. Goereci, M. Schroeter, J. Ingwersen, O. Aktas, L. Klotz,T. Ruck, H. Wiendl, and S.G. Meuth
Open Access
e1024 SARS-CoV-2 Infection in Multiple Sclerosis: Resultsof the Spanish Neurology Society RegistryG. Arrambide, M. Llaneza-Gonzalez, L.C.-F. França, V. Meca-Lallana,E.F. Dıaz, I. Moreno-Torres, J.M. Garcıa-Domınguez,G. Ortega-Suero, L. Ayuso-Peralta, M. Gomez-Moreno,J.J. Sotoca-Fernandez, A.B. Caminero-Rodrıguez,L.A. Rodrıguez de Antonio, M. Corujo-Suarez, M.A. Otano-Martınez,F.C. Perez-Miralles, V. Reyes-Garrido, T. Ayuso-Blanco,J.J. Balseiro-Gomez, M. Muñoz-Pasadas, I. Perez-Molina,C. Arnal-Garcıa, A. Domingo-Santos, C. Guijarro-Castro,C. Iñiguez-Martınez, N.T. Lara, F. Castellanos-Pinedo,T. Castillo-Triviño, D.M. Cerdan-Santacruz, A. Perez-Sempere,B.S. Torres, A.A. de Arcaya, E. Costa-Arpın, E. Duran-Ferreras,M. Fragoso-Martınez, M. Gonzalez-Platas, L. Landete Pascual,J. Millan-Pascual, C. Oreja-Guevara, and J.E. Meca-Lallana
Open Access
Cover ImageAutoantibodies of patients bind to CNTN1 in transfected HEK293 cellsand DRG neurons: Immunoreactivity of sera of patients with contactin-1antibodies with dorsal root ganglia neurons. Panel A shows the lack ofreactivity of serum of a healthy control. Panels B-D show the reactivity ofsera of three patients. Stylized by Haley McNiff, Digital Multimedia/Podcast Coordinator.See page e1056
Continued
e1036Dysregulation of the Adaptive ImmuneSystem in Patients With Early-Stage ParkinsonDiseaseZ. Yan, W. Yang, H. Wei, M.N. Dean, D.G. Standaert, G.R. Cutter,E.N. Benveniste, and H. Qin
Open Access
e1037Dimethyl Fumarate Treatment in Patients WithPrimary Progressive Multiple Sclerosis: ARandomized, Controlled TrialH.H Chow, J. Talbot, H. Lundell, C.G Madsen, L. Marstrand, T. Lange,M.R Mahler, S. Buhelt, R.H Hansen, M. Blinkenberg, J.R Christensen,P.S Sørensen, M. Rode von Essen, H.R Siebner, and F. Sellebjerg
Open Access
e1040 Serum Contactin-1 in CIDP: A Cross-SectionalStudyL. Wieske, L. Martın-Aguilar, J. Fehmi, C. Lleixa,M.J.A. Koel-Simmelink, M. Chatterjee, Z. van Lierop, J. Killestein,C. Verhamme, L. Querol, S. Rinaldi, C.E. Teunissen, and F. Eftimov
Open Access
e1043 The Aryl Hydrocarbon Receptor–DependentTGF-α/VEGF-B Ratio Correlates With DiseaseSubtype and Prognosis in Multiple SclerosisA. Cirac, T. Tsaktanis, T. Beyer, M. Linnerbauer, T. Andlauer,V. Grummel, L. Nirschl, L. Loesslein, F.J. Quintana, B. Hemmer, andV. Rothhammer
Open Access
e1045 Paraneoplastic AQP4-IgG–SeropositiveNeuromyelitis Optica Spectrum DisorderAssociated With Teratoma: A Case Report andLiterature ReviewR. Ikeguchi, Y. Shimizu, A. Shimomura, M. Suzuki, K. Shimoji,T. Motohashi, T. Yamamoto, N. Shibata, and K. Kitagawa
Open Access
e1044Obesity in Pediatric-Onset Multiple Sclerosis:A French Cohort StudyP.Milles, G. De Filippo, H.Maurey, T. Tully, and K. Deiva, on behalf ofthe KidBiosep
Open Access
e1046 A New England COVID-19 Registry of PatientsWith CNS Demyelinating Disease: A PilotAnalysisK.M. Money, A. Mahatoo, S. Samaan, P. Anand, U. Baber, M. Bailey,R. Bakshi, A. Bouley, A. Bower, J. Cahill, M. Houtchens, J. Katz,E. Lathi, E. Levit, E.E. Longbrake, M. McAdams, S. Napoli,P. Raibagkar, P. Wade, and J.A. Sloane
Open Access
e1047 Predicting Aggressive Multiple Sclerosis WithIntrathecal IgM Synthesis Among Patients Witha Clinically Isolated SyndromeE. Monreal, S.S. de la Maza, L. Costa-Frossard, P. Walo-Delgado,J. Zamora, J.I. Fernandez-Velasco, N. Villarrubia, M. Espiño,D. Lourido, P. Lapuente, I. Toboso, J.C. Alvarez-Cermeño,J. Masjuan, and L.M. Villar
Open Access
e1052 International Consensus Recommendations for theTreatment of Pediatric NMDAR AntibodyEncephalitisM. Nosadini, T. Thomas, M. Eyre, B. Anlar, T. Armangue,S.M. Benseler, T. Cellucci, K. Deiva, W. Gallentine, G. Gombolay,M.P. Gorman, Y. Hacohen, Y. Jiang, B.C. Lim, E. Muscal,A. Ndondo, R. Neuteboom, K. Rostasy, H. Sakuma, S. Sharma,S.N. Tenembaum, H.A. Van Mater, E. Wells, R. Wickstrom,A.K. Yeshokumar, S.R. Irani, J. Dalmau, M. Lim, andR.C. Dale
Open Access
e1051 Increased Serum Neurofilament Light and ThinGanglion Cell–Inner Plexiform Layer Are AdditiveRisk Factors for Disease Activity in Early MultipleSclerosisT.-Y. Lin, V. Vitkova, S. Asseyer, I.Martorell Serra, S.Motamedi, C. Chien,M. Ditzhaus, A. Papadopoulou, P. Benkert, J. Kuhle, J. Bellmann-Strobl,K. Ruprecht, F. Paul, A.U. Brandt, and H.G. Zimmermann
Open Access Editorial, p. e1054
e1053 Thymoma and Autoimmune Encephalitis: ClinicalManifestations and AntibodiesM. Guasp, J. Landa, E. Martinez-Hernandez, L. Sabater, T. Iizuka,M. Simabukuro, M. Nakamura, M. Kinoshita, M. Kurihara, K. Kaida,J. Bruna, S. Kapetanovic, P. Sanchez, R. Ruiz-Garcıa, L. Naranjo,J. Planaguma, A. Muñoz-Lopetegi, L. Bataller, A. Saiz, J. Dalmau, andF. Graus
Open Access
e1039 Autoimmune Encephalitis Resembling DementiaSyndromesA.E.M. Bastiaansen, R.W. van Steenhoven, M.A.A.M. de Bruijn,Y.S. Crijnen, A. van Sonderen, M.H. van Coevorden-Hameete,M.M. Nuhn, M.M. Verbeek, M.W.J. Schreurs, P.A.E. Sillevis Smitt,J.M. de Vries, F.J. de Jong, and M.J. Titulaer
Open Access
e1056 Anti–contactin-1 Antibodies Affect Surface Expressionand Sodium Currents in Dorsal Root GangliaJ. Gruner, H. Stengel, C. Werner, L. Appeltshauser, C. Sommer,C. Villmann, and K. Doppler
Open Access
e1055 Impact of Disease-Modifying Treatments of MultipleSclerosis on Anti–SARS-CoV-2 Antibodies: AnObservational StudyK. Bigaut, L. Kremer, T. Fabacher, L. Lanotte, M.-C. Fleury,N. Collongues, and J. de Seze
Open Access
e1041Multiple Sclerosis: circRNA Profile Defined RevealsLinks to B-Cell FunctionA.E. Zurawska, M.P. Mycko, I. Selmaj, C.S. Raine, and K.W. Selmaj
Open Access
e1049 Familial History of Autoimmune Disorders AmongPatients With Pediatric Multiple SclerosisB.M. Greenberg, T.C. Casper, S.S. Mar, J.M. Ness, P. Plumb, S. Liang,M. Goyal, B. Weinstock-Guttman, M. Rodriguez, G.S. Aaen,A. Belman, L.F. Barcellos, J.W. Rose, M.P. Gorman, L.A. Benson,M. Candee, T. Chitnis, Y.C. Harris, I.L. Kahn, S. Roalstad, J. Hart,T.E. Lotze, M. Rensel, J.P. Rubin, T.L. Schreiner, J.-M. Tillema,A.T. Waldman, L. Krupp, J. Graves, K. Drake, and E. Waubant
Open Access
TABLE OF CONTENTS Volume 8, Number 5, September 2021 Neurology.org/NN
e1057COVID-19 in Patients With Neuromyelitis OpticaSpectrum Disorders and Myelin OligodendrocyteGlycoprotein Antibody Disease in North America:From the COViMS RegistryS.D. Newsome, A.H. Cross, R.J. Fox, J. Halper, P. Kanellis, B. Bebo,D. Li, G.R. Cutter, K.W. Rammohan, and A. Salter
Open Access
Clinical/Scientific Notes
e1025 AsepticNeutrophilicMeningitisWithHypoglycorrhachiaFollowing a Single Ocrelizumab InfusionS. Cicero, E. Rissanen, K. Carter, H. Nguyen, R. Petit, T.B. Ellerin,R. Dhillon, and T. Singhal
Open Access
e1048CNS Lymphocytic Vasculitis in a YoungWomanWithCOVID-19 InfectionG.M. Timmons, T. Rempe, E.A. Bevins, V. Goodwill, A. Miner,A. Kavanaugh, M. Ritter, and J.S. Graves
Open Access
e1042CombinedTreatmentWith Pembrolizumab andAllogenicBK Virus-Specific T Cells in Progressive MultifocalLeukoencephalopathy: A Case ReportR. Wicklein, S. Heidegger, M. Verbeek, B. Eiz-Vesper,B. Maecker-Kolhoff, J.S. Kirschke, A. Page, T. Korn, B. Hemmer, andM. Deschauer
Open Access
Views & Reviews
e1033 Autoimmune Neurology: The Need forComprehensive CareJ.R. Abbatemarco, S.J. Rodenbeck, G.S. Day, M.J. Titulaer,A.K. Yeshokumar, and S.L. Clardy
Open Access
Diagnostic and Treatment Challenges
e1026 Encephalitis andMyelitis in a YoungWoman:OverlapSyndrome, Thyroiditis, and Occult Tumor Fromthe National Multiple Sclerosis Society CaseConference ProceedingsN.Z. Esfanhani, A. Wundes, T. Varkey, R.P. Lisak, A. Goodman,J. Graves, S.S. Zamvil, E.M. Frohman, T.C. Frohman, andS.D. Newsome
Open Access
Corrections
e1050COVID-19 Among Patients With Multiple Sclerosis:A Systematic Review
e1072 Encephalitis andMyelitis in a YoungWoman:OverlapSyndrome, Thyroiditis, and Occult Tumor Fromthe National Multiple Sclerosis Society CaseConference Proceedings
TABLE OF CONTENTS Volume 8, Number 5, September 2021 Neurology.org/NN
2021;8; Neurol Neuroimmunol Neuroinflamm 8 (5)
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