69

cell carcinomas and 0/20 squamous cell

carcinomas. We conclude: i) most, but not all, SCLC

and carcinoids express multiple NE markers in a high percentage of tumor cells; 2) occasional (4%) of non small cell lung cancers show staining patterns indistin- guishable from SCLC; 3) many non small cell lung cancers contain a small subpopulation of cells expressing NE markers. These re- sults provide further evidence for a com- mon origin for all lung cancers.

Characteristics of Long-Term Survivors After Treatment for Inoperable Carcinoma of the Lung. Komaki, R., Cox, J.D., Hartz, A.J., By- hardt, R.W., Perez-Tamayo, C., Clowry, L. Department of Radiation Oncology, The Medical College of Wisconsin Affiliated Hos- pitals, Milwaukee, Wisconsin 53226.

Between January, 1971 and August, 1978, 410 patients with histologically or cytolo- gically confirmed inoperable or unresectab- le carcinoma of the lung were treated with curative intent. Forty-five patients lived a minimum of 3 years and 32 patients lived 5 or more years. The 3-year survival rate increased from 7.6% (15/197) between 1971 and June, 1975 to 14.1% (30/213) for the interval from July, 1975 to August, 1978 (p < .01). Factors associated with long- term survival were performance status (p < .01), early stage (p < .001), high total dose of radiations (p < .02), large cell carcinoma (p < .01), inoperable for medical reasons (p < .001), and thoraco- tomy to determine unresectability (p < .04). The difference in survival rates between the two time periods was not related to diffe- rent patient factors. Survival rates were most improved in the second t£me period for patients with stage II or stage III car- cinoma of the lung. Eight patients died from cancer between 36 and 54 months of initial treatment. Five patients died of intercurrent disease without evidence of cancer of the lung after 3 years. An in- creasing proportion of long-term survi- vors of inoperable carcinoma of the lung can be expected to result from a better understanding of these diseases, more tech- nically sophisticated external irradiation, and the use of combination chemotherapy for small cell carcinoma.

Lymph Node Reactivity of Stage I, II Lung Cancer-P[ognosis and Background Factors. Naka~ura , K., Naka~oto , K., Maeda , M., Mori , T., Sawamura , K. i. Department of Surgery, Kagawa Medical School, 2. National Kinki Central Hospital for Chest Diseases.

We set up a score system composed of histological appearance of mediastinal

lymph nodes. One point is to be given on posi- tive sinus histiocytosis, positive paracortical

hyperplasia, negative follicular hyperplasia, and negative hyaline nodules respectively.

Eighty seven patients with pathological stage I, II lung cancer (34 adeno-, 53 epider- mold carcinoma) received surgical resection in Natl. Kinki Central Hospital for Chest Disea- ses during the period since 1975 through 1979. They were classified according to the score,ie group A with 4 points, group B with 3, group C with 2, and group D with one point. Number of cases in each group were ii, 29, 32, 15 respectively.

As the result, five year survivals were 100% in group A, 81% in group B, 33% in group C, and 44% in group D. Significant difference was noted between group A and group C, D, and between group B and group C,D (p < 0.01). As for the backgrounds the score has significant correlation with peripheral blood lymphocyte count (2600 + 610, 2210 ~ 610, 1290 + 990 (p < 0.05)).--Age, DNCB skin test has--correla- tion but not significant (p = 0.14). NO corre- lation wa~ found with sex, pN factor, nor PPD skin test reactivity.

l,m~unocompetence in Lung Cancer. Pierri, I., Rogna, S., Tavano, A., Poggi, A., Ratto, G., Motta, G., Indiveri, F. I.S.M.I. Immunologia Clinica e Semeiotica Chirurgica - Universit~ degli Studi di Genova, Italy.

The aim of this study is to analyze the im- mune competence of patients with lung cancer. To this end we have evaluated (a) the serum le- vel of Ig, complement, circulating immune com- plex and (b) the phenotype and function (s) of lymphocytes in 42 patients with lung cancer.

The data about sera did not show any signi- ficant information with respect to the type and the clinical stage of the disease. The study of lymphocytes has been performed with cells from the peripheral blood and from lymph nodes re- gional of the cancer with a panel of monoclo- nal antibodies (EKTI- TII - T3 - T4 - T8 and Q 5/13, Q 5/06) in an indirect rosette micro- assay and by evaluating their responsiveness upon mitogen, alloantigens and autoandigens activation in vitro.

Lymphocytes from lymph nodes did not show significant phenotypic differences with re- spect to those isolated from peripheral blood. Lymphocytes from lymph nodes as well as PBL underwent blastogenesis upon activation by mi- togens and antigens in vitro. Nevertheless the extent of such activation resulted different with respect to the source of responding and/or stimulator cells.

The present study suggests that the analysis of lymphocytes isolated from lymph nodes re- gional of human malignant tumours may help to understand the host-tumour relationship.

I.mune Reactivity to Thomsen-Friedenreich Anti-

gen in Patients with Lung Cnacer Detected by