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2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
1 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
M. PHARM. I YEAR MEDICINAL & PHARMACEUTICAL CHEMISTRY
SEMESTER – I
2 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
I M.PHARM. SCHEME
(MEDICINAL AND PHARMACEUTICAL CHEMISTRY)
SEMESTER I
S. No. Sub.
Code
Subject
L
T
P Th.
Credit
Pr.
Credit
Maximum Marks
TH CW SW Pr. Total
1. PY 90001 DRA and Intellectual Property Rights 4 - - 4 - 70 30 - - 100
2. PY 99006 Modern Analytical Techniques 4 - - 4 - 70 30 - - 100
3. PY 99007 Product Development and Quality
Assurance 4 - - 4 - 70 30 - - 100
4. PY 99008 Biotechnology & Bio-Informatics 4 - - 4 - 70 30 - - 100
5. PY 99451 Modern Analytical Techniques Lab. - - 4 - 2 - - 40 60 100
6. PY 99452 Product Development and quality Assurance Lab.
- - 4 - 2 - - 40 60 100
7. PY 99453 Biotechnology & Bioinformatics Lab - - 4 - 2 - - 40 60 100
8. PY 99500 Comprehensive Viva - - - - - - - - Grade Grade
Total 16 0 12 16 06 280 120 120 180 700
M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry) 2020-21
2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
3 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
PY 90001: DRA AND INTELLECTUAL PROPERTY RIGHTS
L T P Th.
Credit
Pr.
Credit
Maximum Marks
TH CW SW Pr. Total
4 - - 4 - 70 30 - - 100
Course objectives:
• To provide basic understanding of regulatory affairs applicable to pharmaceutical industry.
• To understand the requirements of good manufacturing practices in pharmaceutical
industry.
• To provide knowledge of ICH guidelines and their applications.
• To understand patent processing for pharmaceutical products and processes.
Course outcomes:
On the completion of the course the student should be able to:
• Develop knowledge about regulatory affairs and intellectual property rights.
• Understand regulatory requirements of national and international markets.
• Understand product registration process for national and international markets.
• Understand regulatory requirements of stability and impurity profiling.
• Understand the documentation required for SUPAC changes in product.
• Draft and process a patent.
THEORY DURATION (LECTURES)
UNIT I 8
International regulation:
(a) USFDA CGMP (21CFR part 211)
(b) Overview of GMP aspect of WHO guidelines, EMEA, MHRA, MCC, TGA, ENVISA
guidelines.
(c) Documentation: manufacturing records, SOP, Site master file, specifications, COA, MSDS, MOA, annual product review, validation protocols, stability protocol and forms.
UNIT II 8
Drug approvals:
New drugs, Regulatory requirements of investigational new drug application. (USFDA 21 CFR
part 310, 312).
UNIT III 8
Drug approvals:
(a) Regulatory requirements to market a new drug for US, new drug application, Abbreviated application. (USFDA 21 CFR part 314).
(b) Scale up and post approval changes guidelines.
2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
4 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
UNIT IV 8
ICH- Guidelines:
(a) Stability (Q1), Impurities (Q3).
(b) Common technical document (CTD): procedure and process for registration of product.
UNIT V 8
Patent and intellectual property rights: (a) Introduction to TRIPS, GATT, WTO.
(b) Definition, Need for patenting, Types of Patents, Conditions to be satisfied by an invention to be
patentable, Introduction to patent search. Parts of patents. Filling of patents. The essential elements of
patent; Guidelines for preparation of laboratory note book, Non-obviousness in Patent, Patent drafting.
(c) PCT Application, Patentability criteria in US and Europe.
(d) Hatch Waxman Act, compulsory licensing.
(e) Infringement proceedings; types of infringement; Case studies for doctrine of equivalents.
(f) Plagiarism and fair use doctrine
BOOKS & REFERENCES RECOMMENDED:
Text books
1. The Gazettes of India. The Drug and Cosmetics Act and Rules and its Latest
amendments.
2. Code of Federal Regulations, 21 CFR Part 211, 310, 312, 314.
3. The Gazettes of India. The Patent Act 1970 and its Latest amendments (patent manual)
4. WHO GMP guidelines
Reference books
1. Willing, Tuckerman and Hitchings, Good Manufacturing Practices for Pharmaceuticals
2. Common Technical documents (ICH guidelines).
Internet references
1. www.fda.gov
2. www.ich.org
3. www.picscheme.org
4. www.mhra.gov.uk
5. www.emea.europa.eu
6. www.tga.gov.au
7. www.mccza.com
8. www.who.int
9. www.ep.espace.net
10. www.patentoffice.ni
c.in
11. www.uspto.gov
12. www.anvisa.gov.
13. www.ipindia.nic.in
14. www.patentlyo.com
2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
5 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
PY: 99006 MODERN ANALYTICAL TECHNIQUES
L T P Th.
Credit
Pr.
Credit
Maximum Marks
TH CW SW Pr. Total
4 - 4 4 2 70 30 40 60 200
Course objectives:
• To develop the basic knowledge of spectra generation and factors affecting the spectra.
• To correlate structure of drug with its spectra.
• To use spectral properties for quantitative analysis of drug substance and drug products.
• To understand the thermal behaviour of materials.
• To develop skills for use of thermal analytical techniques for qualitative analysis of API
and excipients.
• To provide the fundamental of separation in chromatographic techniques.
• To understand the use of chromatography and hyphenated techniques for impurity profiling and potency analysis.
Course outcomes:
After completion of course, student should be able to:
• Perform characterization of various intermediates, impurities, excipients, bulk drugs and
their formulations using FTIR, NMR, X-Ray analysis, Mass spectroscopy, Thermal
techniques.
• Perform qualitative and quantitative analysis of impurities, excipients, drug substances
and drug products using chromatographic techniques.
• Develop methods for the qualitative and quantitative analysis of drug substances and drug
products.
• Perform validation of analytical methods for assay and impurity profiling of drug
substance and drug products.
THEORY DURATION (LECTURES)
UNIT I 8
a) Ultra Violet (UV )and Visible Spectroscopy:
Energy levels and selection rules: Definitions, molecular orbital approach for energy,
absorption, various modes of transitions.
Correlation of structural variation with UV absorption: Factors influencing the position and
intensity of absorptions, Inductive and resonance effects, effect of ring size, influence of
stereochemical factors. Predicting UV absorption: Woodward- Fieser, Fieser-Kuhn and Nelson rules Other factors:
Non-conjugative effect, solvent effect, S-Cis band
b) Infrared (IR) Spectroscopy:
Characteristic regions of the spectrum: Various modes of vibrations, Energy levels.
Correlation of structure with IR spectra: Influence of substituents, ring size, hydrogen
bonding, vibrational coupling and field effect on frequency. Applications: Determination of
stereochemistry. Spectral interpretation with examples.
2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
6 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
FT-NIR: Principle (overtones, combinations, fermi resonance, interferences etc.),
instrumentation (dispersion spectrometer and FT-NIR), advantage and disadvantage,
qualitative and quantitative applications, including PAT and non-destructive analysis.
ATR: Principle (total internal reflection, evanescent wave, etc.), instrumentation (ATR crystal, IR beam), advantages and disadvantages, pharmaceutical applications.
FT-Raman: Principle (absorption, diffraction, scattering and emission of wave, molecular
interaction), instrumentation (Dispersive Raman, FT-Raman), advantage and disadvantage,
pharmaceutical applications including detection of counterfeits.
UNIT II 8
a) Nuclear Magnetic Resonance (NMR) Spectroscopy:
Fundamentals: Physical basis, magnetic nuclei, resonance, relaxation processes, signal-
sensitivity. Instrumentation: Continuous-Wave (CW) instrument, Pulsed Fourier Transform
(FT) instrument, Functions, Relation with sensitivity, Sampling.
1H NMR: correlation of structure with spectra: Chemical environment and shielding,
chemical shift, reference compound, local diamagnetic shielding and magnetic anisotropy,
chemical and magnetic non-equivalence, spin-spin splitting, Pascal's triangle, coupling
constant, mechanism of coupling, integral, NMR solvents and their residual peaks, protons
on heteroatoms, quadrupole broadening and decoupling, effect of conformations and
stereochemistry on the spectrum, Karplus relationship, diastereomeric protons,
Heteronuclear coupling to 19F and 31P, virtual coupling, long range coupling-epi, peri, bay
effects. Shift reagents-mechanism of action, spin decoupling and double resonance.
Explanation of spectra of some compounds and drugs.
13C NMR: correlation of structure with spectra: Chemical environment, shielding and
carbon-13 chemical shift, calculation, proton-coupled 13C Spetra, Proton-decoupled C
spectra, Nuclear Overhauser Enhancement (NOE), Problem with integration, Distortionless
Enhancement by Polarization Transfer (DEFT), Heteronuclear coupling for carbon to
deuterium, carbon to 19F, carbon to 31P. Explanation of spectra of some compounds and
drugs.
b) Atomic spectroscopy:
Atomic absorption spectroscopy:
Basic principle, instrumentation – atomizers, radiation source, background absorption and
background source, applications of atomic absorption spectroscopy. Inductive coupled
plasma spectroscopy.
Atomic emission spectroscopy: Basic principle, applications of atomic emission
spectroscopy. Inductive coupled plasma atomic emission spectroscopy.
UNIT III 8
a) Fluoroscence spectroscopy:
Theory, Jabolanski’s diagram, singlet, doublet and triplet electronic states, Internal and
external conversions, factors affecting fluorescence, quenching, instrumentation and
application b) X-ray analysis:
X-ray absorption spectroscopy – Theory, Instrumentation, Application.
X-ray diffraction analysis - Theory, Instrumentation, Application.
2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
7 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
c) Electrophoresis: Principe, Instrumentation, working conditions, factors affecting separation and
applications of paper electrophoresis, Gel electrophoresis, Capillary electrophoresis, Zone
electrophoresis, moving boundry electrophoresis and isoelectric focusing.
UNIT-IV 8
a) Mass Spectroscopy (MS)
Molecular ion and metastable peak, fragmentation patterns, nitrogen and ring rules,
McLafferty rearrangement, electron and chemical ionization modes, applications. b) Thermal Techniques
DSC: Principle, thermal transitions, instrumentation (Heat flux and power-compensation
designs), Modulated DSC, Hyper DSC, experimental parameters (sample preparation,
experimental conditions, calibration, heating and cooling rates resolution source of errors)
and their influence, advantages and disadvantages, pharmaceutical applications
DTA: Principle, instrumentation, advantage and disadvantage, pharmaceutical application,
derivative differential thermal analysis (DDTA).
TGA: Principle, instrumentation, factors affecting results, advantages and disadvantages,
pharmaceutical application.
UNIT-V 8
a) Chromatographic Techniques:
General principles, classification of chromatographic techniques, normal and reverse phase,
bonded phase chromatography, stationary phases, activity of stationary phases, elutropic
series, and separation mechanisms. Overview and applications of following techniques: I. Column Chromatography and Short Column Chromatography
II. Flash chromatography and Vacuum Liquid Chromatography.
III. High Performance Liquid Chromatography
IV. Planar Chromatography: TLC/HPTLC/OPLC
V. Gas Chromatography
VI. Biochromatography
VII. Hyphenated techniques
b) Analytical method development and validation:
Area normalization method, internal standard method, external standard method, standard
addition method. ICH guidelines for analytical method development and method validation.
Validated spreadsheets.
PRACTICALS: Minimum 15 experiments based on the following:
1. UV-Visible Spectroscopy, FT-IR spectroscopy, HPLC & Electrophoresis.
2. Interpretation of UV, IR NMR and Mass Spectra of some chemical compounds and drugs.
3. Estimation of drugs in Pharmaceutical products and biological fluids.
4. Calibration of analytical instruments and Validation of analytical methods.
BOOKS AND REFERENCES RECOMMENDED
Text books:
1. Kemp W., “Organic Spectroscopy”. 3rd edition, 1991, Palgrave Macmillan.
2. Pavia D.L., Lampman G. M., Kriz G. S., Vyvyan J. A., “Introduction to spectroscopy” 5th
edition, 2015, Cengage learning, USA.
2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
8 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
3. Chan C. C., Lee Y. C., Lam H., Zhang X. M., “Analytical method validation and instrument
performance verification” 1st edition, 2004, Wiley Interscience.
References books:
1. Skoog D. A., Holler F. J., Crouch S. R., “Principles of Instrumental Analysis” 6th edition, 2007, Thomas Brooks/Cole.
2. Silverstein R. M., Webster F. X., Kiemle D., Bryce D. L., “Spectrometric Identification of
Organic Compound” 8th edition, 2014, Wiley..
3. Schirmer R. E., “ Modern methods of Pharmaceutical Analysis” 2nd edition, 1991, CRC
Press.
4. Ewing G. W., “Instrumental Method of Chemical Analysis” 5th edition, 1985, McGraw Hill Higher Education.
5. Snyder L. R., Kirkland J., Glajch J. L., “Practical HPLC Method Development” 2nd edition,
1997, John Wiley and sons.
6. Willard, H.H.; Merritt, L.L. Jr.; Dean, J.A.; Settle, F.A. Jr., Instrumental methods of analysis, 7th
edition, CBS Publisher and distributers.
7. Stanley Crouch, Douglas Skoog, F. Holler, Donald West, “Fundamentals of Analytical Chemistry, “
Cengage learning.
8. D. C. Garratt, “THE QUANTITATIVE ANALYSIS OF DRUGS”, Science paperback.
9. Von G. W. Ewing, “Instrumental Methods of Chemical Analysis”, McGraw‐Hill Book Co., Inc., New
York‐Toronto‐London.
Online resources:
1. ICH guideline Q2(r1)
http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Quality/Q2_R1/St
ep4/Q2_R1 Guideline.pdf
2. http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/
ucm073384.pdf
2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
9 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
PY99007: PRODUCT DEVELOPMENT AND QUALITY ASSURANCE
L T P Th.
Credit
Pr.
Credit
Maximum Marks
TH CW SW Pr. Total
4 - 4 4 2 70 30 40 60 200
Course objectives:
• To provide basic theoretical knowledge and practical skills to apply preformulation studies in product development.
• To impart knowledge of formulation development and technological advancements in
solid, semi-solid, liquid, sterile, and sustained & controlled release dosage forms.
• To provide thorough acquaintance of various concepts of quality assurance, sampling
plans, and process validation.
Course outcomes:
On completion of this subject, students are expected to be able to:
• Perform the preformulation studies for dosage form development.
• Do product development of solid, semi-solid, liquid, sterile, sustained and controlled
release dosage forms.
• Understand the quality assurance, self inspection and quality audit and in-process quality
control.
• Prepare sampling plans, standard operating procedures and product development reports.
• Perform validation of analytical processes, manufacturing processes, and equipments.
THEORY DURATION (LECTURES)
UNIT I 8
a) Preformulation studies: Study of physical, chemical and pharmaceutical factors influencing
formulation of drugs. Drug stability and stability study programs for formulations.
b) Formulation considerations; additives used (diluents, binders, disintegrants, lubricants etc.);
technological advancements and evaluation of solid dosage forms: Tablets, Tablet coatings,
Capsules.
UNIT II 8
Formulation considerations; additives used (vehicles, antioxidants, preservatives, organoleptic
agents, suspending & emulsifying agents, solubilisers and hydrotropic agents); technological
advancements and evaluation of: (a) Liquid dosage forms: Solutions, Suspensions, Emulsions.
(b) Sterile dosage forms: Injections and Ophthalmics.
UNIT III 8
Formulation considerations; additives used; technological advancements and evaluation of:
(a) Semisolid dosage forms: Ointments, Creams, Suppositories.
(b) Sustained and controlled release dosage forms.
2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
10 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
UNIT IV 8
Basic concept of quality assurance system; self inspection and quality audit; in-process quality
control (IPQC) problems in pharmaceutical industry and in-process quality control tests.
Sampling plans. Standard Operating Procedures (SOPs) and Product development reports.
UNIT V 8
Concept of validation. Process validation in manufacturing dosage formulations. Applications of
process validation. Validation of manufacturing and analytical equipments. Validation of
pharmaceutical water system.
PRACTICALS: Minimum 15 experiments based on the following:
• Development and evaluation of tablets, capsules, oral liquids, semisolids and sterile products.
• Effects of formulation factors on properties of solid, semi-solid and liquid dosage forms.
• Designing of sustained/ controlled release dosage forms.
• Stability studies of pharmaceutical formulations.
• Validation of analytical methods and equipments.
• SOP writing, validation protocol writing, and writing of product development reports.
BOOKS & REFERENCES RECOMMENDED:
Text Books
1. Aulton and Taylor, Aulton's Pharmaceutics: The Design and Manufacture of Medicines,
Fourth Edition, 2013, Elsevier.
2. Lachman, Lieberman and Kanig, The Theory and Practice of Industrial Pharmacy, 4th
Edition, 2013, CBS Publishers.
3. Patrick J. Sinko, Martin’s Physical Pharmacy and Pharmaceutical Sciences, Sixth Edition,
2010, Lippincott Williams & Wilkins.
4. Loftus and Nash, Pharmaceutical Process Validation, Third Edition, 2011, Informa
Publishers.
Reference books
1. Banker and Rhodes, Modern Pharmaceutics, Fifth Edition, 2009, CRC Press.
2. OPPI, Quality Assurance Guide – New Edition, Volume I & II, 2001, Organisation of
Pharmaceutical Producers of India. 3. Indian Pharmacopoeia, Seventh Edition, 2014, Indian Pharmacopoeia Commission.
4. United States Pharmacopeia 38 National Formulary 33, 2014, United States Pharmacopoeial Convention.
Internet references
1. www.who.int.
2. www.fda.gov.
2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
11 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
PY 99008: BIOTECHNOLOGY & BIOINFORMATICS
L T P Th.
Credit
Pr.
Credit
Maximum Marks
TH CW SW Pr. Total
4 - 4 4 2 70 30 40 60 200
Course objectives:
• To provide basic understanding of immunology, vaccines, hybridoma technology &
monoclonal antibody production.
• To provide basic knowledge of enzyme & enzyme kinetics, structure and function of the
DNA & RNA and their role in encoding genetic material, functional role of DNA,
concept of recombinant DNA technology, gene cloning, current and future developments
in genetic engineering, applications of molecular biology, properties of cells (prokaryotic
and eukaryotic cells), • To understand the principles of bioinformatics and its importance in pharmacy.
• To provide theoretical knowledge and practice of biostatistics.
Course outcomes:
On completion of this subject, students are expected to be able to:
• Understand immune system, immunity and immune responses.
• Explain antigen-antibody reactions.
• Describe vaccine technologies.
• Explain transmission of a genetic material at cellular levels
• Apply key concept of enzymes & enzyme kinetics.
• Apply techniques for enzyme immobilization.
• Isolate RNA, DNA and proteins using different techniques.
• Apply biostatistics in biological data analysis and interpretation.
THEORY DURATION (LECTURES)
UNIT I 8
a) Immunology: Principles of immunology, Antigens, Antibodies, immune system, antigen-
antibody reactions and their applications, the immune responses. Hybridoma technology:
Production and application of monoclonal antibodies.
b) Vaccines: Conventional vaccines, Modern vaccine technologies, genetically improved live
vaccines, genetically improved subunit vaccines, Pharmaceutical considerations.
UNIT II 8
a) Introduction to Genetics: Structure and Properties of DNA and RNA, Mutation, Transmission
of genetic material, Applications of genetic engineering in Pharmaceutical field, its present
status and future prospects.
b) Recombinant DNA Technology: Constructing Recombinant DNA molecules, Restriction
Enzymes, Vectors, Gene Cloning, Genomics libraries, Polymerase Chain reaction–based
DNA cloning, Restriction mapping, blotting techniques, DNA sequencing, Pharmaceutical
applications of recombinant DNA.
2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
12 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
UNIT III 8
a) Fundamentals of cell biology: Cell organization and plasma membrane, Cellular reproduction,
Cell signaling.
b) Gene Therapy: General introduction, Genomic protein targets, Gene transfer methods, Clinical
studies, Pharmaceutical production, gene expression and regulations, Importance of
CRISPR/Cas9 technology in gene editing.
UNIT IV 8
a) Molecular biology of diseases, Structural biology and rational drug design.
b) Enzymes: Classification and nomenclature, factor affecting enzyme action, Kinetics of
enzyme inhibition, regulation of enzyme activity, allosteric enzymes, Isoenzymes, Enzyme
inhibitors used in treatment of some diseases (Cancer, Bacterial, Viral etc.).
c) Enzyme Immobilization: Techniques of immobilization of enzymes, Enzyme electrodes, Enzyme based sensors, Immobilization of bacteria and cells.
UNIT V 8
a) Introduction to Bioinformatics: Biological databases, Sequence analysis, Protein structure,
Genetic and physical mapping, Applications of bioinformatics in Pharmacy
b) Biostatistics: Introduction – Data, Frequency data. Graphical presentation of data, Descriptive
statistics, Probability and Probability distribution, Sampling, Inferential statistics – ANOVA,
correlation & Regression analysis.
PRACTICALS: Minimum 15 experiments based on following:
• Kinetics of enzyme action, enzyme inhibition and factors affecting the enzymatic reactions.
• Enzyme immobilization techniques.
• Applications of antigen-antibody reactions.
• Separation techniques for RNA, DNA, Peptide and proteins and techniques used for their analysis.
• Delivery techniques of RNA, DNA, Peptides and Proteins.
BOOKS & REFERENCES RECOMMENDED:
Text books 1. Zito S. W. (1997), Pharmaceutical biotechnology: a programmed text. 1st edition Technomic Pub. Co,
Lancaster.
2. Xiong J. (2006), Essential Bioinformatics. 1st edition Cambridge University Press, New York.
3. Desmond S. T. Nicholl (2008), An Introduction to genetic engineering. 3rd edition Cambridge University
Press, New York
4. Nelson D. L., Cox M. M.,(2000) Lehninger Principles of Biochemistry, 3rd edition, Worth Publication.
5. Tortora G. J., Funke B. R., Case C. L.,(2012) Study Guide to Microbiology: An Introduction. 10 th edition,
Pearson Education
Reference books 1. Benjamin L., (2000) Genes VIII. 7th edition, Oxford University Press,
2. Baxevanis A. D., and Quellette B. F. F., (2004) Bioinformatics: A Practical Guide to the Analysis of
Genes and Proteins.2nd edition, John Wiley & Sons.
3. Watson J. D., (1994) Molecular Biology of the Cell 3rd edition Garland Science.
4. Wayson J., Zoller M., Gilman M., and Witkowski J., (1992) Recombinant DNA, 2nd edition. Scientific
American books. 5. William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian (2019)
Concepts of Genetics, 12th Edition, Pearson
2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
13 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
M. PHARM. I YEAR MEDICINAL & PHARMACEUTICAL CHEMISTRY
SEMESTER – II
14 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
I M.PHARM. (MEDICINAL AND PHARMACEUTICAL CHEMISTRY) SCHEME
SEMESTER II
S. No.
Sub. Code
Subject
L
T
P Th.
Credit
Pr.
Credit
Maximum Marks
TH CW SW Pr. Total
1 PY 99505 Advanced Medicinal Chemistry 4 - - 4 - 70 30 - - 100
2 PY 99506 Advanced Organic Chemistry 4 - - 4 - 70 30 - - 100
3 PY 99507 Advanced Pharmaceutical Chemistry 4 - - 4 - 70 30 - - 100
4 PY 99508 Drug Design 4 - - 4 - 70 30 - - 100
5 PY 99851 Advanced Medicinal Chemistry Lab - - 4 - 2 - - 40 60 100
6 PY 99852 Advanced Organic Chemistry Lab - - 4 - 2 - - 40 60 100
7 PY 99853 Advanced Pharmaceutical Chemistry Lab - - 4 - 2 - - 40 60 100
8 PY 99854 Drug Design Lab. - - 4 - 2 - - 40 60 100
9 PY 99881 Research Methodology & Seminar - - 2 - 2 - - 100 - 100
10 PY 99900 Comprehensive Viva - - - - - - - - Grade Grade
Total 16 0 18 16 10 280 120 260 240 900
M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry) 2020-21
2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
15 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
PY 99505: ADVANCE MEDICINAL CHEMISTRY
Sub. Code L T P Th. Cr. Pr. Cr.
Maximum Marks
TH CW SW Pr. Total
PY 99505 (T) 4 - - 4 - 70 30 - - 100
PY 99851 (P) - - 4 - 2 - - 40 60 100
Course objectives:
• To build understanding about the area of chemical drug delivery systems and use of
polymers in drug delivery systems.
• To understand different theories of drug actions at molecular level.
• To develop a realistic approach from structure activity relationship to quantitative
structure activity relationship of new drugs for the treatment of cancer, protozoal
infections, viral infections, inflammation, and hypertension.
• To define combinatorial and disconnection approach for synthesis of drugs.
Course outcomes:
• On completion of this course, the students are expected to be able to:
• Define basic strategy of prodrug designing.
• Develop prodrugs for topical, ocular, and brain delivery.
• Understand basic concept of polymers, polymer synthesis, properties of polymers for
pharmaceutical applications.
• Understand molecular approach of drug action,
• Develop quantitative approaches for improving drug profile.
• Define new strategies for compound library generation and synthesis.
THEORY DURATION (LECTURES)
UNIT I 8
(a) Chemical drug delivery system:
Prodrug concept, hard and soft prodrug, metabolism and role of enzymes in drug
latentiation, functional groups for prodrug formation, mutual prodrug. Basic strategy of
prodrug formation for Improved Aqueous solubility – Modifications employing hydrophilic
functional groups, Modifications employing amino acids, Modifications employing
hydrophobic functional groups, Modifications involving polymers and macromolecules,
chemical and enzymatic liability of the promoiety. Retrometabolic drug design – basic
concept, Prodrug for topical delivery – Physicochemical considerations and implications for
prodrug design, functional group considerations, solubility, molecular size and functional
group effect, effect of partitioning and enzymatic hydrolysis on the percutaneous transport
of lipophilic prodrugs. Prodrugs for Ocular targeting – Factors to consider in the design of
ocular prodrugs. Prodrugs for brain targeting. Factors to consider in the design of prodrugs
for brain targeting.
(b) Polymers for pharmaceutical use:
Basic concept of polymers- definition and descriptive terms, concept of biodegradablility,
biocompatibility, bioreabsorbablility. Principles of polymer synthesis – addition
2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
16 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
polymerization, condensation polymerization, ring opening polymerization. Principles of
polymerization methods – Homogeneous polymerization, dispersion polymerization, bulk
polymerization, melt polymerization, Interpenetrating polymer network,Topology and
isomerism, polymer properties. Basic concept of hydrogels, chemical gel, physical gel,
hydrocollids, conjugate polymer, block polymer, liquid crystalline polymers, star polymer
and hyperbranched polymer. Application of polymers in pharmaceuticals. Study of
polylactic acid and poly-lactide-co-glycolide
(c) Dendrimers:
Basic concept of dendrimers, methods of synthesis- divergent, convergent, click chemistry,
molecular structure, properties, applications. Study of polyamidoamines, poly(propylene)
dendrimers.
UNIT-II 8
(a) Receptor theories, drug receptor interaction, drug target binding forces. Enzyme inhibitors: rational design of enzyme inhibitors.
(b) Antineoplastic agents:
Basic concept, malignant and non malignant tumors, cell cycle, tumor cell properties, targets
of antineoplastic agents, classification. Study of mechanism of action, structure activity
relationship, structure toxicity relationship and biological evaluation of cytotoxic agents,
antimetabolites, hormones, Miscelleneous agents. Receptor/enzyme structure including
some PDB files, quantitative structure activity/toxicity relationship, classical and new
synthetic routes of topoisomerase II inhibitors, carbonic anhydrase inhibitors.
(c) Anti viral and anit HIV agents:
Basic concept, classification of viruses, Infectious process of a virus, targets of antiviral
agents, classification, study of mechanism of action, structure activity relationship, structure
toxicity relationship and biological evaluation of DNA polymerase inhibitors, reverse
transcriptase inhibtitors, protease inhibitors, HIV entry inhibitors – Chemokine receptor
binders, Inhibitors of gp41 fusion activity, Integrase inhibitors. Receptor/enzyme structure
including some PDB files, quantitative structure activity/toxicity relationship, classical and
new synthetic routes of protease inhibitors, reverse transcriptase inhibitors.
UNIT III 8
(a) Immunosuppressants:
Basic concept, targets of immunosuppressants, classification, study of mechanism of action,
structure activity relationship, structure toxicity relationship and biological evaluation of
glucocorticoids, cytostatics, antibodies, drugs acting on immunophilins, miscellaneous drugs (b) Non-steroidal anti-inflammatory agents:
Basic concept, Eicosanoid biosynthesis, targets of non-steroidal anti-inflammatory agents,
classification, Study of mechanism of action, structure activity relationship, structure
toxicity relationship and biological evaluation of antipyretic agents, analgesic agents, anti-
inflammatory agents. Receptor/enzyme structure including some PDB files, quantitative
structure activity/toxicity relationship, classical and new synthetic routes of COX-II
inhibitors.
2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
17 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
UNIT IV 8
(a) Antiprotozoal agents: Basic concept, classification of protozoa.
(b) Antitrypanosomiasis agents: Introduction, Infectious process of Trypanosoma, Targets of
antitrypanosomiasis agents, classification. Study of mechanism of action, structure activity
relationship, structure toxicity relationship and biological evaluation of antitrypanosomiasis
agents.
(c) Antileishmaniasis agents: Introduction, Infectious process of Leishmania, Targets of
antileishmaniasis agents, classification. Study of mechanism of action, structure activity
relationship, structure toxicity relationship and biological evaluation of antileishmaniasis
agents.
(d) Anti malarial agents: Introduction, Infectious process of Plasmodium, Targets of
antimalarial agents, classification. Study of mechanism of action, structure activity
relationship, structure toxicity relationship and biological evaluation of Cinchona alkaloids,
4-Aminoquinolines, 8-Aminoquinolines, dihydofolate reductase inhibitors, tetrahydrofolate
synthase inhibitors. Receptor/enzyme structure including some PDB files, quantitative
structure activity/toxicity relationship, classical and new synthetic routes of dihydrofolate
reductase inhibitors.
UNIT-V 8
(a) Anti-hypertensive agents:
Basic concept, targets of anti- hypertensive agents, classification. tudy of mechanism of
action, structure activity relationship, structure toxicity relationship and biological
evaluation of renin-angiotensin system inhibitors, ACE inhibitors, angiotensin antagonists,
Adrenergic system inhibitors, vasodilating agents. Receptor/enzyme structure including
some PDB files, quantitative structure activity/toxicity relationship, classical and new
synthetic routes of ACE Inhibitors, Angitensin antagonists.
Classification, mode of action, SAR, side effects, biological evaluation and recent advances
in research of the following categories of drugs i. Antiparkinsonian agents
ii. Antialzheimer drugs
iii. Antihyperlipidemic drugs
(b) Combinatorial chemistry - Overview of combinatorial library generation, method of
synthesis and applications, diversity oriented synthesis. Disconnection approach (synthon
approach) - Overview of basic principles, strategies and application.
PRACTICALS: Minimum 15 experiments based on the following:
• Synthesis of prodrug and their characterization
• Hydrolytic kinetics study of prodrug.
• Synthesis of poly-lactic acid using ring opening polymerization.
• Synthesis of polymer drug conjugates of drugs and their characterization.
• Synthesis of polyamidoamine dendrimers.
• Study of QSAR, CoMFA and CoMSIA models and docking studies.
• Synthesis of derivatives using classical and modern methods.
2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
18 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
BOOKS AND REFERENCES RECOMMENDED:
Text books
1. Block J. H., Beale J. M., “Wilson and Gisvold’s Textbook of organic medicinal and
pharmaceutical chemistry”, 11th edition, 2004, Lippincott Williams and Wilkins-A Wolters
Kluwer Company.
2. Lemke T. L., Williams D. A., “Foye’s principles of medicinal chemistry”, 6th edition, 2008,
Lippincott Williams and Wilkins-A Wolters Kluwer Company.
Reference books
1. Wolff M. E., “Burger’s medicinal chemistry and drug discovery” 5th edition, 1995, Wiley-
Interscience, New York.
2. Abraham D.J, Rotella D.P., “Burger’s medicinal chemistry and drug discovery” 7th edition,
2010, Wiley-Interscience, New York.
3. Hansch C., “Comprehensive medicinal chemistry” Vol. I-VI, 1990, Pergamon Press.
4. Jung G., Combinatorial chemistry, synthesis, analysis, screening. 2008, Wiley-VCH,
5. Warren S., Wyatt P., Organic synthesis: the disconnection approach, 2nd edition, 2008,
Wiley-Interscience, New York.
2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
19 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
PY 99506: ADVANCED ORGANIC CHEMISTRY
Sub. Code L T P Th. Cr. Pr. Cr. Maximum Marks
TH CW SW Pr. Total
PY 99506 (T) 4 - - 4 - 70 30 - - 100
PY 99852 (P) - - 4 - 2 - - 40 60 100
Course objectives:
• To provide basic knowledge of stereochemistry, chiral and achiral molecules, structural
isomers (constitutional isomers), stereoisomers including enantiomers and diastereomers,
racemic mixture, and meso compounds.
• To provide basic understanding of reactions & mechanism for acylations, alkylation,
condensation, halogention, reduction and rearrangement reactions.
• To build understanding of methods of group protection & deprotection.
• To provide understanding and practice of microwave assisted synthesis & optimization.
Course outcomes:
On completion of this subject, students are expected to be able to:
• Draw structural isomers (constitutional isomers), stereoisomers including enantiomers and diastereomers, racemic mixture, and meso compounds.
• Understand the reactions mechanism of acylations, alkylation, condensation, halogention reduction and rearrangement reactions.
• Predict protection & deprotection of functional groups.
• Write reactions & mechanism of Heck, Negishi, Sonogashira and Suzuki coupling.
• Perform microwave assisted synthesis & optimization for various organic synthesis.
THEORY DURATION (LECTURES)
UNIT I 8
Stereoisomerism, condition for optical activity, optical isomerism, racemic modification,
resolution of racemic modification, synthesis of optically active compounds. The actual shape of
six membered rings its properties, reactivity and stability, conformations and reactivity in open
chain and cyclic systems.
UNIT II 8
Protective groups for –OH, -NH2, -COOH. Special protective groups for aldehydes/ ketones such
as oxazolidines [A.I. Meyer’s reagent] and 1,3-dithianes. Methods for the deprotection of above
groups.
Microwave assisted synthesis.
UNIT III 8
Acylations (schotten-baumann, weinreb amide formation, acylation using EDCI, HOBt, DCC).
Alkylations (finkelstein, the mono alkylation of betaketoester or malonate ester, alkylation of
2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
20 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
amine with alkyl bromide) condensations (Knoevenagel condensation, mukaiyama aldol
condensation).
UNIT IV 8
Halogenations (chlorination of alcohol, acid chloride from acid, chlorination of aromatic ring
from hydroxyl group, bromination of alcohol, radical bromination of benzylic position).
Reduction by LiAlH4, NaBH4 and DIBAL, decarboxylations, coupling reactions: Heck, Negishi,
Sonogashira, Suzuki, hydrolysis of esters.
UNIT V 8
Rearrangements: Pinacol-pinacolone, arandt-eistert, benzil-benzilic acid, hoffmann, curtius,
lossen, schimdt, beckmann, bayer-villger, clasien rearrangements, birch reduction, mannich
reaction, wittig reaction, meerwin ponnderof verley reduction, oppenauer oxidation, ozonolysis,
hydrogenation of double, triple bonds and aromatic rings.
PRACTICALS: Minimum 15 experiments based on following:
• Synthesis of organic compounds based on the multi-step reactions.
• Purification of organic compounds using molecular sieves, molecular distillation, fractional
crystallization, column chromatography, crystallization techniques, preparative TLC, etc.
• Asymmetric synthesis.
• Resolution of racemic mixtures.
• Structure confirmation by spectroscopic methods.
BOOKS AND REFERENCES RECOMMENDED
Text books
1. Eliel E. L., Wilen S. H., Stereochemistry of Organic Compounds, Second edition, Wiley- Interscience.
2. Morrison R. T., Boyd R. N., Bhattacharjee S. K., Organic Chemistry, 7th Edition, Pearson
India
3. Finar I. L., Organic Chemistry, Volume 1, 6th Edition, Pearson India.
4. Grahm Solomons T. W., Fryhle C. B., Organic Chemistry 10th edition, Wiley India.
5. Clayden J., Greeves N., Warren S. and Wothers, Organic Chemistry first edition, Oxford
Univ.
Reference books
1. Smith M. B., March J., March's Advanced Organic Chemistry: Reactions, Mechanisms, and
Structure, 6th edition, Wiley India Pvt. Ltd. New Delhi.
2. Sykes P., A guide book to Mechanism in Organic Chemistry, 6th edition, Pearson India
Internet references
1. http://www.sciencedirect.com
2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
21 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
PY99507: ADVANCED PHARMACEUTICAL CHEMISTRY
Sub. Code L T P Th. Cr. Pr. Cr. Maximum Marks
TH CW SW Pr. Total
PY 99507 (T) 4 - - 4 - 70 30 - - 100
PY 99853 (P) - - 4 - 2 - - 40 60 100
Course objectives:
• To develop knowledge about isolation, separation and purification techniques of Natural Products.
• To know the plant biosynthetic pathways.
• To learn chemistry and structure elucidation of natural products like Steroidal hormones,
Alkaloids, Glycosides, Vitamins, Antibiotics, Marine Products and Nutraceuticals.
Course outcomes:
After completion of course, student should be able to:
• Understand the Chemistry, Isolation and Separation Methods of Steroidal hormones,
Peptides, Vitamins, Alkaloids, Glycosides and Antibiotics.
• Understand extraction techniques like Supercritical Fluid Extraction and Solid Phase
Micro Extraction.
• Understand biosynthetic pathways like Shikimic acid, Acetate and Mevalonate.
• Understand importance of Marine Products and Nutraceuticals.
THEORY DURATION (LECTURES)
UNIT I 8
Techniques involved in extraction and isolation with Specific reference to herbal products:
(a) Supercritical fluid extraction: Sample preparation, selection criteria and properties of
supercritical fluid, critical parameters of SFE, instrumentation and application.
(b) Solid phase micro extraction: Introduction, instrumentation, application
(c) Flash Chromatography: Principle, instrumentation and application.
UNIT II 8
Basic Metabolic pathways for production and application of secondary metabolites
(a)Acetate pathway
(b)Shikimate pathway (c) Mevalonate pathway
(d) Principles and application of Tracer techniques.
UNIT III 8
Biosynthesis and Chemistry of following
(a)Adrenocorticoids
(b)Sex hormones
(c)Peptides and their derivatives viz. Thyroid hormones, Oxytocin, Insulin
(d)Vitamin-E
2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
22 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
UNIT IV 8
Isolation and Phytochemical studies of some important constituents in
(a)Digitalis glycosides
(b)Senna Glycosides
(c)Cinchona alkaloids
(d)Rauwolfia alkaloids (e) Ergot alkaloids
(f) Opium Alkaloids
UNIT V 8
(a) Isolation from microorganism and chemistry of Antibiotic with special references to
Macrolides, Beta lactam and amino glycoside antibiotics (b) Marine products of therapeutic potential
(c) Nutraceuticals (d) Introduction, isolation and purification of flavanoids, General methods of structural determination of
flavanoids; Strutural elucidation of quercetin.
PRACTICALS: Minimum 15 experiments based on the following:
• Isolation and purification of natural products like Alkaloids, glycosides, peptides,
Antibiotics and vitamins.
• Structure elucidation and conformational analysis of natural products like Alkaloids,
glycosides, peptides, and vitamins.
BOOKS AND REFERENCES RECOMMENDED
Text books
1. Dewick P. M., Medicinal Natural Products: A Biosynthetic Approach, 32nd edition, 2009,
John Wiley & Sons Inc. 2. Finar I. L., Organic Chemistry,5th edition, 2002, Pearson India,
3. Evans W. C., Trease and Evans, Pharmacognosy, 2nd edition, 2001, Elsevier Science Health
Science Div.
4. Torsell K.B.G. Natural Products Chemistry, 2nd edition, 1997, Swedish P’ceutical Press.
Reference books
1. Liang X. T. , Fang W. S., Medicinal Chemistry of Bioactive Natural Products, 1st edition,
2011, Wiley India. 2. Melentyeva G., Antonova L., Pharmaceutical chemistry, 1988, MIR Publisher.
3. Fieser L. F., Fieser M., Steroids, 1960, Reinhold Publishing Corporation.
4. Wickery M.L., Wickery B. Secondary Plant Metabolism, 1981, The Macmillan Press Ltd.,
London. 5. Harborne J.B., Phytochemical Methods, 3rd edition, 2008, BSP Books Pvt Ltd.
6. Fattorusso E, Gerwick, W. H., Taglialatela S.O. Handbook of Marine Natural Products, 1st edition, 2012, Springer.
2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
23 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
PY 99508: DRUG DESIGN
Sub. Code L T P Th. Cr. Pr. Cr. Maximum Marks
TH CW SW Pr. Total
PY 99508 (T) 4 - - 4 - 70 30 - - 100
PY 99854 (P) - - 4 - 2 - - 40 60 100
Course objectives:
• To provide basic understanding about drug designing process.
• To impart fundamental knowledge of stereochemistry and drug action, drug and
xenobiotic transformation, computational tools and techniques.
• To understand the significance of steric, stereochemical, conformational and electronic
factors for drug design.
Course outcomes:
On completion of this subject, students are expected to be able to:
• Understand drug design concepts: QSAR, computer aided drug designing, drug target
selection, molecular modeling, computational techniques, stereochemistry, receptor
pharmacology.
• Perform homology modeling, docking, pharmacophore methods and techniques of
modern drug design.
• Understand the relationship between chemical structure and biological activity of drug.
• Design and develop new leads on a rational basis.
THEORY DURATION (LECTURES)
UNIT I 8
Physico-chemical properties and biological activity. Stereochemistry and drug action. A general
study of correlation of physicochemical and biological properties with drug activity. Isomerism
and Bioisosterism.
UNIT II 8
Drug & Xenobiotic biotransformation: Drug bio-transformational system, Cytochrome P-450
Classification and basic structure, Main Human CYP Families, Cytochrome P-450 Catalytic role,
Phase I System, Mechanism of Induction & Inhibition of Phase I Enzyme, Phase II & III process,
Factors affecting ADME and Insilico predication of ADME properties.
UNIT III 8
Receptor theory and Drug-receptor interactions: Macromolecular structures, dose response
relationship, drug receptor geometry, general features of receptor site, drug related binding
complexes, nature of drug receptor bonds. Drug design for unknown target, known target and
other targets.
2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
24 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
UNIT IV 8
Computational Tools and Techniques: (i) Homology Model Building, (ii) Docking, (iii)
Pharmacophore models, (iv) QSAR Studies.
UNIT V 8
Virtual screening techniques and applications, combined target based ligand based design
approach and library design.
PRACTICALS: Minimum 15 experiments based on following
• Application of Maestro (GUI), Ligand Preparation, Protein Preparation, Docking, Pharmacophore, and Binding site Analysis, ADME predication, Regression Analysis etc.
• Calculation of values for different types of parameters using tables and softwares.
• QSAR studies.
BOOKS AND REFERENCES RECOMMENDED
Text books
1. Ariens E. J., Drug Design, Volume (1,2,3,4,5,6,7), Academic press, New York.
2. Foye W.O., Williams D. A., Foye W. O., Lemke T. L., Foye's Principles of Medicinal Chemistry, fifth edition, Lippincott - Williams & Wilkins.
3. Abraham D. J., Burger's Medicinal Chemistry and Drug Discovery 6th edition, Wiley.
Reference books
1. Purcell W. P., Bass G. E., Clayton J. M., Strategy of Drug Design: A Guide to Biological
Activity, 1st edition, John Wiley & Sons.
2. Kubinyi H., Mannhold R., Krogsgaard-Larsen P, Timmerman H. QSAR: Hansch Analysis
and Related Approaches, volume 1st , Wiley.
3. Kubinyi H., 3D QSAR in Drug Design: Volume 1: Theory Methods and Applications, 1st
edition, Springer.
4. Patrick G. L., An Introduction to Medicinal Chemistry, 5th edition, Oxford University Press-
New Delhi.
2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
25 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
PY-99881: RESEARCH METHODOLOGY & SEMINAR
L T P Th. Cr. Pr. Cr. Maximum Marks
TH CW SW Pr. Total
- - 2 - 2 - - 100 - 100
Course objectives:
• To identify any contemporary topic from the thrust area of current pharmaceutical
research, regulatory affairs, drug discovery & current affairs of medicinal and
pharmaceutical chemistry and any other field beyond the syllabus.
• To do exhaustive search of literature and information reported in the area of seminar
topic.
• To develop in-depth understanding on seminar topic and prepare the power point presentation.
• To develop the skills of scientific presentation in front of scientific community.
Course outcomes:
On completion of this activity, students are expected to be able to:
• Know different sources of scientific literature and current pharmaceutical news/information.
• Collect information/subject knowledge and identify the relevant topic in thrust area of interest of pharmaceutical field beyond the syllabus contents.
• Develop skills and confidence of seminar presentation and extempore discussion with
scientific fraternity.
2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
26 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
M. PHARM. II YEAR MEDICINAL & PHARMACEUTICAL CHEMISTRY
SEMESTER – III
2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
27 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
PY 9962: DISSERTATION PHASE-I
L T P Th. Cr. Pr. Cr. Maximum Marks
TH CW SW Pr. Total
- - 20 - 20 - - 100 150 250
Course objectives:
• To identify the thrust area in the field of drug design, pharmaceutical chemistry, new analytical method development through literature survey.
• To design and plan the research objectives and methodologies using computational tools
& other techniques.
• To formulate rationale plan of work for the selected problems.
• To procure research tools and consumables for planned research.
• Attempt to complete approx. 25% of planned experimental work.
Course outcomes:
Upon completion of this course, students should be able to:
• Get insight into current research and development in the field of drug design,
pharmaceutical chemistry and analytical method development through exhaustive literature survey.
• Design and plan the research objectives and methodologies using computational tools &
techniques.
• Develop rationale plan of work for the selected problems.
• Procure research tools and consumables as per plan of work.
• Complete approx. 25% of planned experimental work.
2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
28 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
M. PHARM. II YEAR MEDICINAL & PHARMACEUTICAL CHEMISTRY
SEMESTER – IV
2020-21 M. Pharm. I & II Year Syllabus (Medicinal and Pharmaceutical Chemistry)
29 Department of Pharmacy, Shri G.S. Institute of Technology & Science, Indore
PY 9985: DISSERTATION PHASE-II
L T P Th. Cr. Pr. Cr. Maximum Marks
TH CW SW Pr. Total
- - 30 - 30 - - 160 240 400
Course objectives:
• To pursue advanced concepts, emerging research methodologies and recent experimental tools for carrying out the planned research work.
• To carry on the planned experimental work & optimize methodology.
• To pursue the experimental findings & draw conclusion.
• To establish correlation of results obtained & publication of research.
• To develop research orientation and aptitude in the field of drug design, pharmaceutical
chemistry and analytical method development.
Course outcome:
Upon completion of this course, students should be able to:
• Understand advanced concepts and recent experimental tools in the area of research
completed.
• Develop themselves as upcoming researcher in the emerging fields of drug design,
pharmaceutical chemistry and analytical method development.
• Do value addition to the existing knowledge in the research field through scientific
presentation & publications.
• Complete the planned work in the stipulated time, correlate the findings after compilation and submit the dissertation for evaluation.