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Major Histocompatibility complex OR. MHC. تفاوت آنتي ژنهاي سازگاري. ساختمانی ژنی توزیع سلولی معرفی نوع پپتید سلول شناسایی کننده. MHC. The principal function of T cells are : Defense against intracellular microbes Activation of other cells(B cells ,Macrophages ) - PowerPoint PPT Presentation
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Major Histocompatibility Major Histocompatibility complexcomplex
OROR
MHCMHC
تفاوت آنتي ژنهاي سازگاريتفاوت آنتي ژنهاي سازگاري
ساختمانیساختمانی
ژنیژنی
سلولی سلولی توزیع توزیع
پپتید نوع پپتید معرفی نوع معرفی
کننده شناسایی کننده سلول شناسایی سلول
MHCMHC
The principal function of T cells are :The principal function of T cells are :Defense against intracellular microbesDefense against intracellular microbesActivation of other cells(B cells ,Macrophages )Activation of other cells(B cells ,Macrophages )
peptide recognition by T and B cells peptide recognition by T and B cells is different.is different.
B cells recognize soluble as well as cell associated AgsB cells recognize soluble as well as cell associated AgsIn contrast ,T cells recognize peptide which is displaying only In contrast ,T cells recognize peptide which is displaying only
by APC in associated with MHC proteins.by APC in associated with MHC proteins.
MHCMHC MHC genes are the most MHC genes are the most polymorphicpolymorphic genes genes MHC genes are MHC genes are codominantlycodominantly expressed in expressed in
each individualeach individual There are There are two main two main type of MHC:class I & IItype of MHC:class I & II The physiologic function of MHC molecules The physiologic function of MHC molecules
is is presentation of peptides to T cells presentation of peptides to T cells ,control ,control of immune responsiveness to all proteins of immune responsiveness to all proteins and graft rejectionand graft rejection
MHC-I present cytosolic peptides to T MHC-I present cytosolic peptides to T cytotoxic cells and MHC-II present cytotoxic cells and MHC-II present endocytosed peptides to Thendocytosed peptides to Th cellscells
MHC –I structureMHC –I structure
MHC-II structureMHC-II structure
T cell receptor and MHC T cell receptor and MHC interactioninteraction
Polymorphism of class IIPolymorphism of class II
HLA-DPA 12HLA-DPA 12 HLA-DPB 88HLA-DPB 88 HLA-DQA 17HLA-DQA 17 HLA-DQB 42HLA-DQB 42 HLA-DR >400HLA-DR >400
POLYMORPHISM OF MHC PROTEINS
DR 1 HLA-A >280
DR >400 HLA-B >500
DQ >50 HLA-C >130
Variability is in the amino acid residues in the peptide binding site!