Scientific Names: 1.) Mimosa pudica Linn. 2.) Mimosa asperata Blanco 3.) Han xiu caoCommon Names: Bashful Mimosa, Sensitive Plant, MakahiyaTaxonomical Classification:KingdomPlantae

SubkingdomTracheobionta

SuperdivisionSpermatophyta

DivisionMagnoliophyta

ClassMagnoliopsida

SubclassRosidae

OrderFabales

FamilyFabaceae/ Leguminosae

GenusMimosa L.

SpeciesMimosa pudica L.

Folkloric Use:1. roots used as diuretic; also used for dysentery and dysmenorrhea.2. Entire plant in decoction used as alterant and antiasthmatic.3. Root considered aphrodisiac, and used for bladder gravel and similar urinary complaints.4. Decoction or infusion of leaves used in asthma; expectorant.5. Used for hypertension, menorrhagia, glandular swelling, sore throat and hoarseness.6. Powdered seeds applied to wounds and sores.7. Bruised leaves applied to bruises.8. Decoction of leaves used for diabetes.9. Powdered roots and leaves taken with milk for piles and fistula.10. Juice applied externally to fistulous sores.11. Poultice of leaves for glandular swellings.12. Leaves and roots used for piles and fistula. 13. 1:1 ethanol water extract used for pain relief.14. Infusion of leaves used for dysentery; also as bitter tonic.15. Leaves used for hydrocoele, hemorrhoids, fistula, scrofula, conjunctivitis, wounds and hemorrhages.16. Whole plants used for bladder calculi; externally, for edema, rheumatism, myalgia and uterine tumors.17. Whole plant, crushed, used for itching and scabies.Pharmacological/Pharmaceutical Uses:1. Antimicrobial: Study showed antimicrobial activity against Aspergillusfumigatus, Citrobacterdivergens and Klebsiella pneumonia.2. Antifungal:Study evaluated the antifungal activity of M. pudica extract against five potentially pathogenic microorganisms: Trichophytonmentagrophyte, T. verrocuson, Microsporumnanum, Aspergillusniger, and A. flavus. Antifungal activity against the isolates increased significantly with concentration. No activity was seen against Aspergillusniger. 3. Anti-Hepatotoxic / Antioxidant: Study showed the co-administration of Mimosa pudica aqueous extract significantly lowered the level of lipid peroxidation in alcohol-fed mice. 4. Antidiabetic Activity: In a study of alloxan-induced diabetic rats, the ethanolic extract of Mimosa pudica showed significant decrease of blood glucose level compared with Metformin as standard drug. 5. Hypolipidemic:Chloroform extract exhibited significant hypolipidemic activity. Results suggest that biologically activity phytoconstituents such as flavonoids, glycosides alkaloids may be responsible for the activity. 6. Antinociceptive / Toxicity Studies:In an acute toxicity study, a single dose of aqueous extract of 2000 mg KBW showed no clinical signs of toxicity or mortality. Study also showed dose-dependent central and peripheral analgesic property. 7. Tannins / Antivenom:Study showed tannins obtained from M. pudica was better than tannic acid in neutralizing the lethality of N. kaouthia venom in vitro. Results suggest M. pudica has a potential for treating N. Kaouthia snakebites. 8. Wound Healing: Study of the methanolic extract exhibited good wound healing activity, an effect attributable to phenol constituents.Study of shoot and root extracts showed good wound healing activity when compared to standard drug Gentamicin. (3) In an incision wound model, topical application of chloroform and methanolic root extracts showed wound-healing activity with a significant rise in breaking strength, dry weight, and hydroxyproline content of the granulation tissue. 9. Hepatoprotective:Study evaluated the hepatoprotective effect of a methanolic extract of leaves of M. pudica in carbon tetrachloride induced liver damage in wistar albino rats. Results showed significant hepatoprotective effect with lowering of biochemical parameters and confirming histopathological changes. Results were comparable to standard hepatoprotective drug Silymarin. Effects may be due to active phytoconstituents flavonoids, glycosides, and alkaloids. 10. Antiulcer:Evaluation in rats of extracts of M. pudica for anti-ulcer activity in ulcer models -- aspirin, alcohol, and pyloric ligation -- showed the alcoholic extract to significantly decrease the volume of gastric acid secretion, PH, free acidity and ulcer index. 11. Antioxidant:Study evaluated the in vitro antioxidant effect of an ethanolic extract of Mimosa pudica against free radical damage by different assay methods (DPPH, NO, ABTS, and H2O2). Results showed potent activity on Nitric Oxide and DPPH, compared to ascorbic acid and rutin as standards. 12. Anti-Inflammatory / Leaves:Study evaluated an ethanolic extract of M. pudica leaves using carrageenan induced paw edema and cotton pellet granuloma testing in albino rats. Results showed significant dose dependent anti-inflammatory effect in acute and chronic phases of inflammation. 13. Antitumor / Glycosylflavones:Six glycosylflavones isolated from Mimosa pudica were evaluated for antitumor activity. Results showed inhibition on the proliferation of three tumor cells studies, viz., MCF-7, JAR, and N-2 A. 14. Anti-Asthmatic / Roots:Study evaluated the antiasthmatic activity of aqueous extract of Mimosa pudica on in vitro and in vivo animal models. Results showed anti-asthmatic activity which could be attributed to bronchodilating, antihistaminic (H1-antagonist), mast cell stabilizing properties, suggesting potential in prophylaxis and management of asthma. 15. Adaptogenic / Nootropic:Study evaluated the adaptogenic activity of an ethanolic extract of Mimosa pudica in chronic Alzheimer's model. Results showed significant improvement in memory, observed from test models viz., morris water maze, radial arm maze. For adaptogenic testing, using Forced swim test, the EEMP showed significant reduction in swimming endurance time. Results suggest the EE at dose of 500 mg/kbwp.o. produces potential changes in chronic Alzheimer's model and stress. 16. Pilot Clinical Studies Menorrhagia: 1986 Pilot clinical studies evaluated Mimosa pudica in women with excessive menstrual bleeding. Findings showed promise for further detailed trials in a larger sample size of patients with dysfunctional uterine bleeding. Tolerability of M. pudica was good. Result suggest conventional phase 1 studies with organ function tests, prior to embarking on large scale phase III studies.The root is used for dysentary with blood / mucus, piles and urinary calculi. The fresh juice of leaves is given internally to stop bleeding

REFERENCESScientific Names: http://www.stuartxchange.com/Makahiya.htmlCommon Names: http://kalusugan.ph/halamang-gamot-makahiya/Taxonomical Classification: http://plants.usda.gov/core/profile?symbol=MIPU8Folkoric use: http://www.stuartxchange.com/Makahiya.htmlPharmacological/Pharmaceutical Use:Phytochemical Screening and Antimicrobial Activity of the Plant Extracts of Mimosa pudica L. Against Selected Microbes/ N Gandhiraja et al / Ethnobotanical Leaflets 13:618-24, 2009Evaluation of wound healing activity of root of Mimosa pudica/ Kokane D D et al / J Ethnopharmacol. 2009 Jul 15;124(2):311-5. Epub 2009 May 3Antihepatotoxic and antioxidant defense potential of Mimosa pudica/ Nazeema T.H. and Brindha V./ International Journal of Drug Discovery, ISSN: 09754423, Volume 1, Issue 2, 2009, pp-01-04Antidiabetic activity of the leaves of mimosa pudicalinn in albino rats/ N G Sutar et al / Journal of Herbal Medicine and Toxicology 3 (1) 123-126 (2009)Antinociceptive Activity of Mimosa pudica Linn/M Karthikeyan and M K Deepa / Iranian Journ of Pharma and Therapeutics, Jan 2010, Vol 9, No 1, 11-14Hypolipidemic Activity of Chloroform Extract of Mimosa pudica Leaves/ RekhaRajendron and EkambaramKrishnakumar / Avicenna Journal of Medical Biotechnology, Vol. 2, No. 4, October-December 2010Efficacy of tannins from Mimosa pudica and tannic acid in neutralizing cobra (Najakaouthia) venom/ Sia FY, Vejayan J, Jamuna A, Ambu S / The Journal of Venomous Animals and Toxins including Tropical Diseases, 2011, Vol 17, No 1, Pp 42-48Wound healing activity of mimosa pudicalinn formulation/ S.Kannan , S.Aravinth Vijay Jesuraj, Sam Jeeva Kumar, K.Saminathan et al /International Journal of PharmTech Research, Vol.1, No.4, pp 1554-1558, Oct-Dec 2009

Group 8|3FPHSISON/TOLENTINO A/TOLENTINO R/UY/VILLANUEVA A