Absorption, Distribution, Metabolism, and Excretion of Ticagrelor in Healthy Subjects Six healthy male subjects (aged 40–55 years) were enrolled in the study. The health status of each volunteer was determined during a screening visit (visit 1) based on medical history, physical examination, electrocardiogram, and clinical laboratory test results. Subjects were excluded if they had participated in studies involving radiolabeled substances in the past 12 months or were monitored for radioactivity as part of their job; had symptoms of clinically relevant illness; had any disease or condition known to interfere with the absorption, distribution, metabolism, or excretion of drugs; had severe allergic disease; or had demonstrated hypersensitivity to any drugs related structurally or mechanistically to ticagrelor. Enam subyek sehat (laki-laki berusia 40-55 tahun) laki-laki yang terdaftar dalam studi. Status kesehatan masing-masing relawan ditentukan selama kunjungan pemeriksaan (Kunjungan 1) berdasarkan riwayat medis, pemeriksaan fisik, Elektrokardiogram, dan hasil tes laboratorium klinis. Subyek dikeluarkan jika mereka telah berpartisipasi dalam penelitian yang melibatkan pelacak zat dalam 12 bulan terakhir atau dimonitor untuk radioaktivitas sebagai bagian dari pekerjaan mereka; memiliki gejala penyakit secara klinis relevan; telah adanya suatu penyakit atau kondisi yang dikenal untuk mengganggu penyerapan, distribusi, metabolisme, atau ekskresi obat-obatan; menderita penyakit alergi parah; atau telah
Absorption, Distribution, Metabolism, and Excretion of
Ticagrelorin Healthy Subjects
Six healthy male subjects (aged 4055 years) were enrolled in the
study.The health status of each volunteer was determined during a
screening visit(visit 1) based on medical history, physical
examination, electrocardiogram,and clinical laboratory test
results. Subjects were excluded if they had participatedin studies
involving radiolabeled substances in the past 12 months orwere
monitored for radioactivity as part of their job; had symptoms of
clinicallyrelevant illness; had any disease or condition known to
interfere with theabsorption, distribution, metabolism, or
excretion of drugs; had severe allergicdisease; or had demonstrated
hypersensitivity to any drugs related structurallyor
mechanistically to ticagrelor.
Enam subyek sehat (laki-laki berusia 40-55 tahun) laki-laki yang
terdaftar dalam studi. Status kesehatan masing-masing relawan
ditentukan selama kunjungan pemeriksaan (Kunjungan 1) berdasarkan
riwayat medis, pemeriksaan fisik, Elektrokardiogram, dan hasil tes
laboratorium klinis. Subyek dikeluarkan jika mereka telah
berpartisipasi dalam penelitian yang melibatkan pelacak zat dalam
12 bulan terakhir atau dimonitor untuk radioaktivitas sebagai
bagian dari pekerjaan mereka; memiliki gejala penyakit secara
klinis relevan; telah adanya suatu penyakit atau kondisi yang
dikenal untuk mengganggu penyerapan, distribusi, metabolisme, atau
ekskresi obat-obatan; menderita penyakit alergi parah; atau telah
menunjukkan hipersensitif terhadap obat-obatan terkait struktural
atau mechanistically untuk ticagrelor.
