7/25/2019 Malignant Tumor

1/14

Malignant Tumor

7/25/2019 Malignant Tumor

2/14

Classifcation The WHO classifes primary brain tumours

on the basis o cell o origin and histologicalgrade

The common primary brain tumours are : gliomas meningiomas (15 ! per cent o total" pituitary adenomas (1!15 per cent o total" #estibular sch$annomas%

&rade 1 is applied to 'benign lesions &rade ) implies high grade malignancy

7/25/2019 Malignant Tumor

3/14

7/25/2019 Malignant Tumor

4/14

7/25/2019 Malignant Tumor

5/14

-resentation Most brain tumours $ill present $ith

one or more eature related to theollo$ing triad: raised ./- sei0ures ocal defcit

7/25/2019 Malignant Tumor

6/14

Primary Brain Tumours Gliomas (43%) Meningiomas (18%)

Schwannoma (8%) Pituitary tumours (12%) % Craniopharyngiomas ( %) %

!loo" #essel tumours (2%) %

7/25/2019 Malignant Tumor

7/14

&liomas These are tumours o glial cell origin% ubtypes :

2strocytomas Oligodendrogliomas 3pendymomas Mi+ed tumours%

7/25/2019 Malignant Tumor

8/14

$strocytomas The common est type% They are usually malignant % They can occur any$here in the cerebral

hemispheres, medulla, brainstem %-ea* incidence is in )th decade % They can be difuse, solid or cystic % They contain starshaped cells resembling adult

neuroglial cells%2strocytic gliomas are graded as Grades I, II, III, IVbased on the quantity o adult and primitive cells %

7/25/2019 Malignant Tumor

9/14

&rade . /ystic &rade .. 4i use &rade ... 2naplastic &rade .6 Glioblastoma multi orme

.t is high grade aggressi#e type o astrocytoma% .t is treated by surgical remo#al 7 debul*ing8 high

dose radiotherapy, chemotherapy $ith carmustine

inserted into the surgical ca#ity and oraltemo0olomide% Median sur#i#al is 1 months8 9year sur#i#al rate

is 5 or less

7/25/2019 Malignant Tumor

10/14

-athological specimen o aglioblastoma multi orme

7/25/2019 Malignant Tumor

11/14

/T scan sho$ing astrocytomagrade .6;glioblastoma multi orme%

7/25/2019 Malignant Tumor

12/14

M

7/25/2019 Malignant Tumor

13/14

7/25/2019 Malignant Tumor

14/14

re erence =aileys > ?o#e@s -ractice o urgery

A th edition