MALLEUS

SRI CHUSNIATI

Departement of Vet. MicrobiologyFaculty of Veterinary Medicine

Airlangga University

MALLEUS

INGUS JAHATGLANDERS

FARCYROTZ

O : Eubacteriales F : Brucellaceae

G : MalleomycesSp : -Malleomyces mallei Malleus

-Malleomyces pseudomallei = Pseudomonas pseudomallei

Mellioidosis

Caused :Malleomyces mallei= Pseudomonas mallei= Burcholderia mallei

Sources of infection :secrete from nostril, excreta

from chronic vulnus, saliva,

tears, urine and feces

Routes of infection :OralInhalationSkin wound

The characterized of the disease :zoonotic, acute and chronicMajority host sensitive at horse and equidae Human : fatal at about + 95% if no handled

Dog, cat, goat moderate sensitive Sheep, pig, cattle resistant guinea pig, mice as an animals

experimental

Morphology :Straight bacilli, pleumorphic, aerobic0,3-0,5 um x 0,7-5 umNon motileNegative Gram

Spore & capsule negative Easy growth at standard medium

Biochemistry characterized :Indol, nitrate reduction, MR/VP negativeH2S, NH3, Enzymes of : Catalase, oxidase and gelatinase positive

Clinical symptoms Acute performs

Fever, disphnoeDischarge from nostril at periodicallySwelling at submaxillaris lymphoglandulae + painfullCachexia to be died at 2 weeks

Its too weak, cough, discharge from nostril, intermittent fever

Swelling at submaxillaris lymphoglandulae Lesion/nodules in internal noose and skin

farcy

Chronic performs

Pathology anatomy :Rhinitis catarrh purulentHigh degree infection rupture in septum nasi star spots Pulmo & pleura: gray's nestCavum thorax : fibrins exudates Liver, lymph, testis caseousSwelling at submaxillaris lymphoglandulae

specificSkin : ulcus & nodule as a lymph circulations to fall off their hairs & cicatrisation

3 kinds of malleus : Nose of malleus Lung of malleus can be represented

together Skin of malleus

Nose of malleus : Nodules at septum nasi obstruction on cavum nasi

broke out mucopurulent secrete and ulcers. Swelling at submaksilaris lymphoglandulae If recovery Cicatrisation on skin substances with

star perform

Lung of malleus : Majority by adverse of nose malleus infection Nodules consist of pus & poly morfo nuclear (PMN)

cell at the outer rings Chronic Skin substances damage and than they

would be substitute with cicatrix skin substance TBC like perform

Skin of malleus :Series Nodules perform at surface of lymph node circulation

(systemic infection by lymph node circulations).Broke out perform ulcus/ulcera with pus excreta

Pathogeneses: Inhalation rhinitis catharalis rhinitis

purulenta eruption at mucous of nose. Proteolysis enzyme presented (bacteria) mucous irritation discharge nasal & ulcera. Ulcera sica “keropeng” (outer skin fall out) & cicatrisation perform cicatrisation with star perform/stella distribute to be nasopharynx tract cough.

Bacteria in bronchus ulcer exudates auscultation examinations sounds of ronchi

Oral digestives tract.

Proteolytic enzyme mucous irritation ulcera bacteria distributed after insertion from blood circulation lymph node circulation predilection (lung & septum nasi). The bacteria avilable at discharge of nose, pus from the part of swelling body, saliva, tear of eyes, feces and urine.

From skin vulnus (temporary) hematogen lymph node circulation nodules series at outer surface of lymph node circulation broke out ulcus & pus excreta, if the vulnus skin to be dried would be produced “keropeng”.

Diagnosis :

Clinical symptom Mallein test

• Ophthalmic mallein test 2-3 drops of mallein saccus conjunctiva R/ + conjunctivitis purulent after 1-2 days.

• Intra dermal test

0,1 cc mallein id measuring the thick of skin before injection and 12 hours after injection

if > 60% + < 60% -

If the test have a negative result re-test in after 2-3 weeks from the first R/ + + malleus please to be killed - free from malleus

-Isolation and identificationTo be isolation from lesion & will be growth up

on- Glycerin agar- Glycerin potato

adverse examination by biochemistry test

-Biologist test

- intra peritoneal administrated against to

guinea pig/ male mice orchitis

-Serologist test

Handling material Handling material (going to be laboratories) :(going to be laboratories) :

infected animal (ante mortem)infected animal (ante mortem) : serum → serologist: serum → serologist Swab by sterile cotton of nasal discharge Swab by sterile cotton of nasal discharge

(pus) → bacteriologist test(pus) → bacteriologist test

infected animal (post mortem) : Swelling organ infected animal (post mortem) : Swelling organ substances (cavum nasi, lung, testicle, liver):substances (cavum nasi, lung, testicle, liver): - Still make it fresh- Still make it fresh - Growth up on Glycerin agar- Growth up on Glycerin agar - Test by male guinea pig after injected intra- Test by male guinea pig after injected intra peritonealperitoneal

DD/.Nasal discharge

Strangles = “ Ingus tenang” = Adenitis equorum = Droes c/ Streptococcus equi (Gram +) acute Curve of fever was specific illustrated :

Initial of action at performing abscess on lymph node The peak of body temperature was

presented The broke out abscess (spontaneous /chirurgic) declined body temperature gradual recovery

Nodules and skin ulcers

Epizootic lymphangitis / “selakarang” Histoplasma farciminosa (fungi)

Ulceratif lymphangitis Corynebacterium pseudotuberculosis Melioidosis Pseudomonas pseudomallei

distributed the biggest nodules (“bungkul bungkul”)

Dourine Trypanosoma equiperdum “Dollar spot”predilection at mucose

membrane

Swelling lymph node Tbc Neoplasma

Predilection at septum nasi The recovery process was to

long term processed, with fatal implication

Verry contagious No vaccination

Therapeutics : Its too difficult, because :