Manganese(II) Complexes as Potential Contrast Agents for MRI

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Contrast Agents for Clinical MRI (T1)

T1 contrast agents:Gd-DTPA, Gd-DOTA, Gd-oxalate…increase signals by decreasing the T1 of protons

Invest. Radiol. 1993, 28, 521-526.

Left: normal brain MRI.Right: Brain MRI in presence of Gd3+

Gd3+ contrast agents have some problem

nephrogenic systemic fibrosis

What metal ion have more unpaired electrons?

Mn2+

Comparison of the stability constants[a] for the Mn2+ complexes of the studied ligands with those for other relevant ligandsdiscussed in the text.

Defined as KML = [ML]/[M] [L]; KHML = [HML]/[ML][H+]