PROTECT AGAINST RECURRENT PYODERMA

Staphage Lysate (SPL)®

MANUFACTURED BY DELMONT LABORATORIES, INC.

30 YEARS OF CLINICAL EXPERIENCE. YEARS OF SUCCESSFUL OUTCOMES.

VISIT US AT DELMONTLABS.COM

*All dogs were treated with SPL® and antibiotics for initial 6 weeks. At week 6, antibiotics were discontinued and SPL® treatment alone significantly controlled pyoderma.

Significantly better response by dogs treated with SPL® in reduction of recurrent pyoderma compared to placebo.*

PROVEN EFFICACY AND SAFETY

Demonstrated performance as documented in the American Journal of Veterinary Research.

Evaluation was conducted in a double-blind placebo-controlled study at the School of Veterinary Medicine, University of Wisconsin-Madison.

In clinical use, side-effects were very rarely reported, including minimal reactions at site of injection such as redness, itching and/or swelling.

Recurrence Seen

Control Evident

Antibiotic Needed

1 None

3 Mild

5+ Severe

Yes

Yes Yes

Yes

No

1.00

2.31

2.462.62

3.25 3.38

1.00

1.50

2.00

2.50

3.00

3.50

0 6 10 14 18

Antib

iotic

Adm

inist

ered

SPL 77%

Response Rate

1.92

Clin

ical

Eva

luat

ion

Sco

re

Placebo46%

Response Rate

Evaluation of a commercial

staphylococcal bacterin for management

of idiopathic recurrent superficial pyoderma

in dogs.

DeBoer DJ, Moriello KA, ThomasCB, Schultz KT. Am J Vet

Res. 1990 Apr;51(4):636-9.

2 Mild Yes No

4 Mild to Moderate

Yes

Time (weeks)

SCORING SYSTEM

No

No

BUILDS THE DOG’S OWN INNATE IMMUNE SYSTEM

It contains several of the most powerful known stimulators of cytokines, including peptidoglycan and lipoprotein.

STAPHAGE LYSATE (SPL)®

ADMINISTERED

T HELPER CELLS ACTIVATED

CYTOKINES RELEASED

IL-1

IFN-

LP PGN

LP AND PGN RELEASED INTO

THE IMMUNE SYSTEM

PHAGOCYTES ACTIVATEDSTAPH INGESTED

AND LYSED BY PHAGOCYTES

PGN AND LP OF LYSED BACTERIA RELEASED BACK INTO IMMUNE

SYSTEM

PGN - PEPTIDOGLYCANLP- LIPOPROTEIN

(PAMP) PATHOGEN-ASSOCIATED MOLECULAR PATTERNproposed method of natural immunity stimulation

Dogs with compromised immune systems cannot rely on their innate immunity to protect themselves from staphylococcal skin infection.

SPL® strengthens the innate immune response to staphylococcal species by stimulating phagocytosis and activating an anti-staph response.

(PAMP) PATHOGEN-ASSOCIATED MOLECULAR PATTERNproposed method of natural immunity stimulation*

*Toll-like receptors (TLRs) in innate immune defense against Staphylococcus aureus. Pietrocola G, Arciola CR, Rindi S, Di Poto A, Missineo A, Montanaro L, Speziale P. Int J Artif Organs, 2011; 34 (9): 799-810.

Staphage Lysate (SPL)®

NATURALLY DERIVED PRODUCTMade of staphylococcal cellular components, bacteriophage and

beef heart infusion broth. Additionally, it is preservative free and has no known contraindications.

REDUCES THE RISK OF ANTIBIOTIC RESISTANT STAPH

Designed for long-term use eliminating any gaps in protection. Reduces infection by opportunistic bacteria, breaking the

never-ending cycle of allergy to infection and reducing the risk of antibiotic resistant bacteria due to repeated rounds of antibiotics.

EASY TO FOLLOW DOSING SCHEDULEDogs are commonly treated with the same dose size of SPL®.

Slight adjustments can be made for extremely large or small dogs. Following the initial 12 weeks of bi-weekly treatment, a simple protocol is followed with treatments tapered until an optimal

maintenance schedule is reached.

BACKED BY EXPERT SUPPORTFree consultations with a board certified veterinary

dermatologist are available to answer any of your clinical questions and guide you through the treatment process.

MANUFACTURED IN THE UNITED STATES BY DELMONT LABORATORIES, INC. 715 HARVARD AVENUE P.O.BOX 269, SWARTHMORE, PA 19081

800-562-5541 | DELMONTLABS.COM | 2017V.1

Staphage Lysate (SPL)®

-

PROTECT AGAINST RECURRENT PYODERMA