Reactions 1207 - 21 Jun 2008

■ Many prescribers may not recognise potentiallyharmful drug-drug interactions, according to resultsfrom a survey conducted in the US. Prescribers wereasked to classify 14 drug pairs as "should not be usedtogether", "may be used together but with monitoring","no interaction" or "not sure". Nine hundred and fiftyprescribers responded to the survey. On average,< 50% of the drug pairs were correctly classified byrespondents. Among contraindicated drug pairs, onlysildenafil and isosorbide mononitrate was correctlyclassified by the majority of respondents (80.7%).Most respondents used printed materials (24.1%) orpersonal digital assistants (25.9%) for information ondrug-drug interactions. Prescribers reported that theywere usually informed about drug-drug interactions bythe pharmacist.Ko Y, et al. Prescribers’ knowledge of and sources of information for potentialdrug-drug interactions: a postal survey of US prescribers. Drug Safety 31:525-536, No. 6, 2008 801089259

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Reactions 21 Jun 2008 No. 12070114-9954/10/1207-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved