Mark D Parker

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Mark D. Parker, PhD Assistant Professor

(Updated: 24 March 2017)

Work: 124 Sherman Hall, 3435 Main Street, Buffalo, NY 14214

Home: 231 Columbia Drive, Buffalo, NY 14221

Office: 716-829-3966 • Lab: 716-829-5321 • Mobile: 216-925-2034

e-mail: parker28@buffalo.edu

Website: http://medicine.buffalo.edu/content/medicine/faculty/profile.html?ubit=parker28

Education

2000: PhD. Department of Biochemistry, University of Bristol School of Medical Sciences, Bristol, UK.

1995: BSc (Hons). Department of Biochemistry, University of Bristol School of Medical Sciences

Professional Appointments

2013-present: Assistant Professor. Department of Physiology and Biophysics, Department of Ophthalmology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York: The University at Buffalo, Buffalo, NY.

2008-2013: Instructor. Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH.

2007-2008: Senior Research Associate. Department of Physiology and Biophysics, Case Western Reserve University School of Medicine.

2003-2004: Visiting Postdoctoral Fellow. Department of Physiology, University of Bristol School of Medical Sciences, Bristol, UK.

2003-2007: Associate Research Scientist. Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT.

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2000-2003: Postdoctoral Research Assistant. Department of Biochemistry, University of Bristol School of Medical Sciences.

Awards & Honors

2012: The Recognition Award for Meritorious Research by a Young Investigator from the American Physiological Society (Renal Section).

2015: Carl W. Gottschalk Research Scholar of the American Society of Nephrology (ASN) Foundation for Kidney Research.

2015: United University Professions (UUP) Discretionary Award.

“To reward and encourage excellence in teaching, scholarship or creative activity, campus and community service, or professional performance”

2016: United University Professions (UUP) Discretionary Award.

2017: New Investigator Award from the American Physiological Society (Cell Section). “The Award recognizes an outstanding investigator in the early stages of his/her career”

2017: IUPS Travel Award from the American Physiological Society

Other Experience and Professional Society Memberships

2014-present: SUNY Eye Institute.

2013-present: American Society of Nephrology.

2011-present: American Physiological Society.

2016-present: Council on Undergraduate Research.

2016-present: The Association for Research in Vision and Ophthalmology

Invited Presentations

International Audience

2003: The Red Cell Club. Yale University, New Haven, CT. “Membrane spans 6 and 7 of the human red cell anion exchanger (band 3; AE1) mask an anion channel.”

2007: Experimental Biology Meeting. Washington, DC. “IRBIT functionally enhances the electroneutral Na/HCO3 cotransporter NCBE by sequestering an autoinhibitory domain.”

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2010: Bicarbonate Transport Satellite Meeting at the 53rd Annual Meeting of the Canadian Society of Biochemistry, Molecular and Cellular Biology. Banff, Canada. “Comparing the Na/HCO3/Cl transporters SLC4A8 and SLC4A10.”

2011: Bicarbonate Transporter Meeting. Aarhus University, Aarhus, Denmark. “Evidence for an interaction between the amino-terminal and transmembrane domains of NBCe1.”

2013: International Union of Physiological Sciences Meeting. Birmingham, UK. “Structure-function relationships of Na+-coupled HCO3

− transporters.”

2013: IUPS H+-SSS Satellite Symposium. University of Oxford, UK. “Structure-function relationships of mutant Na+-coupled HCO3

− transporters.”

2014: Membrane Transport Group Seminar. University of Alberta, Edmonton, Canada. “A Shortage of Baking Soda: Defective bicarbonate transport in individuals with acidic blood.”

2017: International Union of Physiological Sciences 38th World Congress. Rio de Janeiro, Brazil.

“Bicarbonate transporters and eye pathophysiology”

Regional Audience

2012: Visual Sciences Research Center Annual Symposium, CWRU, Cleveland, OH. “The molecular basis of ocular disorders associated with defects in the electrogenic Na/HCO3 cotransporter.”

2014: SUNY Eye Institute Symposium, Syracuse, NY. “The basis of eye diseases associated with defective bicarbonate transporters.”

Local Audience

2009: Case Western Reserve University Department of Pediatrics Seminar, Cleveland, OH. “Functional comparison of four human Na+-driven Cl-HCO3 exchanger variants.”

2009: CWRU Department of Physiology and Biophysics Retreat, Geneva-on-the-Lake, OH. “Molecular dissection of the Na+-driven Cl-HCO3 exchanger.”

2011: CWRU Department of Physiology and Biophysics Retreat, Geneva-on-the-Lake, OH. “Evidence for an interaction between the amino-terminal and transmembrane domains of NBCe1.”

2012: CWRU Nephrology Research Conference, Cleveland, OH. “Renal sodium bicarbonate cotransporters in health and disease.”

2012: CWRU Department of Physiology and Biophysics Retreat, Cleveland, OH. “Genetic links between sodium bicarbonate transporters & blood-pressure traits.”

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2014: Molecular and Developmental Genetics Seminar, Roswell Park Cancer Institute, Buffalo, NY. “The importance of sodium-coupled bicarbonate transporters.”

2014: MSTP Seminar, University at Buffalo, Buffalo, NY. “Bicarbonate transport in health and disease.”

2014: Department of Ophthalmology Joint Vision Lab Group Meeting, VA Hospital, Buffalo, NY. “The molecular basis of eye diseases associated with defective bicarbonate transporters.”

2015: Department of Ophthalmology Joint Vision Lab Group Meeting, VA Hospital, Buffalo, NY. “What is a boron transporter doing in the corneal endothelium?”

2016: University at Buffalo, Oral Biology Seminar, Buffalo, NY. “A Shortage of Baking Soda: Defective bicarbonate transport in individuals with acidic blood and abnormal teeth.”

2016: Department of Ophthalmology Joint Vision Lab Group Meeting, VA Hospital, Buffalo, NY. “The role of a novel proton channel in corneal health and disease.”

2017: Exercise and Nutrition Sciences Seminar, University at Buffalo, Buffalo, NY. “A Shortage of Baking Soda: Defective Bicarbonate Transporters in Individuals with Acidic Blood.”

Service to the Profession

Editorial Advisory Board Member

2016-present

The American Journal of Physiology: Cell Physiology (IF: 3.4)

Ad hoc reviewer

The American Journal of Physiology: Renal Physiology (IF: 3.4)

Biochemistry (IF: 3.0)

FEBS Letters (IF: 3.2)

Frontiers in Membrane Physiology and Biophysics (IF: 4.0)

The International Journal of Cancer (IF: 5.5)

IUBMB Life (IF: 2.7)

The Journal of Physiology (IF: 4.7)

Methods (Elsevier) (IF: 3.5)

Physiological Genomics (IF: 2.6)

PLoS ONE (IF: 3.5)

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Reviewed grant application for National Research Foundation of Korea

Reviewed abstracts for the Council on Undergraduate Research

Consultant

2008-2009 Carigent Therapeutics Inc. New Haven, CT.

Medical School Service

Committee member

2014

Alternate Reviewer, PhD Program in Biomedical Sciences (PPBS) Admissions Committee.

2015

Primary Reviewer, PhD Program in Biomedical Sciences (PPBS) Admissions Committee.

2016

Primary Reviewer, PhD Program in Biomedical Sciences (PPBS) Admissions Committee.

Secretary, UB JSMBS Faculty Council

Secretary, UB JSMBS Faculty Council Steering Committee

Member, JSMBS Standing Committee for Facilities Planning and Budget 2017

Secretary, UB JSMBS Faculty Council

Secretary, UB JSMBS Faculty Council Steering Committee

Member, JSMBS Standing Committee for Facilities Planning and Budget

Alternate Reviewer, PhD Program in Biomedical Sciences (PPBS) Admissions Committee.

Poster Judge

2014-2017

UB Medical Student Research Forum.

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Department Service

Committee Member

2008-2012

Retreat Planning Committee. Department of Physiology and Biophysics. Case Western Reserve University.

2016

Search Committee for new faculty member. Department of Physiology and Biophysics. UB.

Seminar Organization

2015

Arranged visit of Mitchell Chesler MD, PhD from NYU Langone Medical Center for Physiology and Biophysics Seminar “Extracellular pH transients provide and autocrine boost of pyramidal neuron excitability”

2016

Arranged visit of Eric Delpire, PhD from Vanderbilt University Medical Center for Physiology and Biophysics Seminar “Use of CRISPR/Cas9 technology to probe the role of KCC3 in peripheral nerve degeneration”

2017

Organization Committee for Hong Memorial Lecture.

Courses Taught

Case Western Reserve University

2009 (10 hours)

Block 2. The Human Blueprint. “Cell Signaling” (60 min discussion. Small group of first-year medical students)

Block 4. Homeostasis. “Cardiac Physiology” (60 min discussion. Small group of first-year medical students)

PHOL432. Cell Structure and Function. “Basic Genetic Mechanisms” (2 x 90 min lectures. Small group of graduate students)

PHOL456. Proteins and Nucleic Acids. “Methods in Genetics and Molecular Biology” (5 x 60 min lectures. Small group of graduate students)

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2010 (7 hours)

Block 2. The Human Blueprint. “Cell Signaling” (60 min discussion. Small group of first-year medical students)

Block 4. Homeostasis. “Cardiac Physiology” (60 min discussion. Small group of first-year medical students)

PHOL456. Proteins and Nucleic Acids. “Methods in Genetics and Molecular Biology” (5 x 60 min lectures. Small group of graduate students)

2011 (8 hours)

Block 2. The Human Blueprint. “Cell Signaling” (60 min discussion. Small group of first-year medical students)

Block 4. Homeostasis. “Cardiac Physiology” (60 min discussion. Small group of first-year medical students)

PHOL456. Proteins and Nucleic Acids. “Methods in Genetics and Molecular Biology” (5 x 60 min lectures. Small group of graduate students)

BIOL340. Biology Seminar Series. “Whole body pH regulation” (60 min lecture. Large group of undergraduate students)

2012 (11 hours)

Block 2. The Human Blueprint. “Cell Signaling” (60 min discussion. Small group of first-year medical students)

Block 4. Homeostasis. “Cardiac Physiology” (60 min discussion. Small group of first-year medical students)

PHOL456. Proteins and Nucleic Acids. “Methods in Genetics and Molecular Biology” (5 x 60 min lectures. Small group of graduate students)

BIOL340. Biology Seminar Series. “Whole body pH regulation” (60 min lecture. Large group of undergraduate students)

PHOL481. Medical Physiology I. “Renal water and acid-base homeostasis” (2 x 90 min lectures. Large group of graduate students).

2013 (5 hours)

Block 2. The Human Blueprint. “Cell Signaling” (60 min discussion. Small group of first-year medical students)

Block 4. Homeostasis. “Cardiac Physiology” (60 min discussion. Small group of first-year medical students)

PHOL481. Medical Physiology I. “Renal water and acid-base homeostasis” (2 x 90 min lectures. Large group of graduate students).

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University at Buffalo

2014 (14 hours)

BMS511. Fundamentals in Biomedical Sciences - Critiquing Scientific Literature. 6 x 60 min discussion. 5 graduate students.

PGY405/505. Cell & Membrane Physiology. “Trans-epithelial Transport” (8 x 60 min lectures. 15-20 undergraduate and graduate students)

2015 (17 hours)

BMS511. Fundamentals in Biomedical Sciences - Critiquing Scientific Literature. (7 x 60 min discussion. 6 graduate students)

PGY405/505. Cell & Membrane Physiology. “Trans-epithelial Transport” (8 x 60 min lectures. 15-20 undergraduate and graduate students)

PGY498. Undergraduate Research. (2 credit hours of lab supervision, 1 undergraduate student)

2016 (33 hours)

BIO497. Honors Undergraduate Research (‘uncredited’, 1 undergraduate student)

BMS511. Fundamentals in Biomedical Sciences - Critiquing Scientific Literature. (5 x 60 min discussion. 4 graduate students)

PGY405/505. Cell & Membrane Physiology. “Trans-epithelial Transport” (7 x 60 min lectures. 15-20 undergraduate and graduate students)

PGY412. Applied Physiology. “Salt and Water Imbalances” (2 x 60 min lectures, 238 undergraduate students)

PGY498. Undergraduate Research. (8 credit hours of lab supervision, 4 undergraduate students)

PGY502. Mammalian Physiology. “Renal Physiology” (9 x 60 min lectures, 88 first-year dental students)

PMY302. Introduction to Pharmacology. “Renal Physiology and Diuretics” (1 x 120 min lecture, ~200 undergraduate students)

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2017 to date (15 hours)

BIO487. Honors Research Methods (‘uncredited’, 1 x 60 min seminar)

BIO497. Honors Undergraduate Research (‘uncredited’, 1 undergraduate student)

PGY498. Undergraduate Research. (2 credit hours of lab supervision, 2 undergraduate students)

PGY502. Mammalian Physiology. “Renal Physiology” (9 x 60 min lectures, 88 first-year dental students)

PMY302. Introduction to Pharmacology. “Renal Physiology and Diuretics” (1 x 120 min lecture, ~200 undergraduate students)

PGY552R. Human Physiology II Recitation. (2 x 120 min small group discussions with 4 graduate students)

Research Supervision

Graduate Students

2014-2017 Evan J. Myers (PhD candidate). Graduated in May 2017.

2015: Winner of Meritorious Research Travel Award from the Epithelial Transport Group of the American Physiological Society

2015: Oral Presentation at the American Physiological Society’s Epithelial Transport Group Meeting in Boston, MA “A novel missense mutation in the NBCe1 gene (SLC4A4) and a novel mode of inheritance for proximal renal tubular acidosis”

2015: Poster Presentation at Experimental Biology Meeting in Boston, MA.

2015: Poster Presentation at the PPBS recruitment day.

2015: Middle Authorship on a review in Cell Mol LIfe Sci (Impact Factor 5.8)

2015: Middle Authorship on a research article in Scientific Reports (Impact Factor 5.6)

2016: Poster presentation at the Experimental Biology meeting in San Diego, CA.

2016: Winner of American Physiological Society’s Robert Gunn Award

2016: First authorship on manuscript in J Physiol (Impact Factor 4.1)

2016: Winner of ASN Kidney STARS Award from the American Society of Nephrology

2016: Poster Presentation at ASN Meeting in Chicago, IL.

2016: First authorship on manuscript in AJP: Cell (Impact Factor 3.4)

Fall 2015: Adaline Verhoski (PPBS graduate student) Lab rotation.

2016: Poster Presentation at Women in STEM meeting, Buffalo, NY

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Undergraduate Students

Summer 2014: Caroline Brotski (Medical student). Summer program part-funded by a fellowship from unrestricted funds to the Department of Ophthalmology from ‘Research to Prevent Blindness’.

2015: Poster Presentation at Medical Student Research Day. 2015: Abstract Authorship at Experimental Biology meeting.

Fall 2015-Summer 2016: Joseph Jessee (Biomedical Sciences undergraduate student) 2 credit hours per week under the PGY498 research program

2016: Awarded UB Undergraduate Research Award (CURCA) 2016: Poster Presentation at UB’s Celebration of Academic Excellence

Spring 2016-present: Adam Gulkarov (Biological Sciences undergraduate student) 2 credits under the PGY498 research program and more recently 6 credits under BIO497.

2016: Awarded UB Undergraduate Research Award (CURCA) 2016: Appointed as CURCA Research Ambassador 2017: Poster Presentation at UB’s Celebration of Academic Excellence

Summer 2016: Emily Salerno (Biological Sciences undergraduate student) Summer student from Notre Dame

2017: Poster Presentation at EB Meeting in Chicago, IL.

Fall 2016, Spring 2017: Umar Yasin (Biological Sciences undergraduate student) 2 credits (Fall), 1 credit (Spring) under the PGY498 research program

Fall 2016, Spring 2017: Alasanne Mballo (Biomedical Sciences undergraduate student) 2 credits (Fall), 1 credit (Spring) under the PGY498 research program

2017: Poster Presentation at UB’s Celebration of Academic Excellence 2017: Poster Presentation at SUNY Undergraduate Research Conference in

Fredonia, NY

Service on Dissertation Committees

2013: Ismail Sayin (MA). Dept. Biology, CWRU.

2014: Darshan Sapkota (PhD). Dept. Ophthalmology, SUNY: UB.

2014: Tera Domaradzki (MA). Dept. Physiology and Biophysics, SUNY: UB.

2014-2015: Ryan Schwab (MA). Dept. Physiology and Biophysics, SUNY: UB.

2015: Huei-Ying Chen (PhD). Dept. Neuroscience and Physiology, New York University School of Medicine.

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2015: Rose Jacobson (MA). Dept. Physiology and Biophysics, SUNY: UB.

2015: Brian Williams (PhD). Dept. Physiology and Biophysics, SUNY: UB.

2015-present: Robert Jones (PhD). Dept. Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, SUNY: UB

2016-present: Christopher Chapman (PhD). Exercise Science

2017: Nicolas Thor (MA). Dept. Physiology and Biophysics, SUNY: UB.

Research Support

Active

Start-up funds from The Dean of The School of Medicine and The Department of Physiology and Biophysics at SUNY Buffalo.

Role: PI Project Title: n/a Funding Agency: n/a Effective Dates: Nov 2014-Jul 2018

Completed

National Institute of Neurological Disorders and Stroke Award (R01-NS18400) Role: Key personnel PI: Walter Boron Project Title: Molecular Physiology of Bicarbonate Transport in the Brain Funding Agency: NIH Effective Dates: Oct 2003- Aug 2013 Total Costs: approx.. $450,000 per year

National Institute of Diabetes and Digestive and Kidney Diseases Award (R37-DK30344)

Role: Key personnel PI: Walter Boron Project Title: Physiology of Electrogenic Na/HCO3 Transporters Funding Agency: NIH Effective Dates: Oct 2003- Nov 2012 Total Costs: approx. $350,000 per year

Yale Liver Center Pilot Feasibility Grant (P30-DK34989) Role: PI of subaward Project Title: Regulation of Intracellular pH in Hepatocytes- A Proteomic Approach Funding Agency: NIH center core grant award to the Yale Liver Center Effective Dates: Sep 2004-Feb 2006 Total Costs: $25,000

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National Heart, Lung and Blood Institute Award (F32-HL090969) Role: Key personnel PI: Alanna Morrison (subaward to Walter Boron) Project Title: Role of the Solute Carrier Gene Family in Hypertension. Funding Agency: NIH Effective Dates: Jun 2010- Jun 2013 Total Costs: approx.. $250,000 per year

National Eye Institute Pilot Project Award (R21-EY021646) Role: Co-I (with Michael Jennings, PhD) Project Title: Functional role of transporter Slc4a11 (BTR1/NaBC1) in the cornea. Funding Agency: NIH Effective Dates: Dec 2011- Nov 2013 Total Costs: $415,993

Carl W. Gottschalk Research Scholar Grant Role: PI Project Title: Cause and Consequence of Acidosis by the Sodium/bicarbonate

Cotransporter NBCe1 Funding Agency: American Society of Nephrology Effective Dates: Jul 2015- Jun 2017 Total Costs: $200,000

http://medicine.buffalo.edu/news_and_events/news.host.html/content/shared/smbs/news/2015/08/parker-asn-award-5036.detail.html

Pre-UB Publications

Peer-reviewed research papers

1. Parker MD, Ourmozdi EP and Tanner MJ. Human BTR1, a new bicarbonate transporter superfamily member and human AE4 from kidney

Biochem. Biophys. Res. Commun. 282: 1103-1109, 2001.

2. Parker MD and Tanner MJ. The disruption of the third extracellular loop of the red cell anion exchanger AE1 does not affect electroneutral Cl-/HCO3

- exchange activity.

Blood Cells Mol. Dis. 32: 379-383, 2004.

3. Lu J, Daly CM, Parker MD, Gill HS, Piermarini PM, Pelletier MF and Boron WF. Effect of human carbonic anhydrase II on the activity of the human electrogenic Na/HCO3 cotransporter NBCe1-A in Xenopus oocytes.

J. Biol. Chem. 281: 19241-19250, 2006.

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4. Toye AM, Parker MD, Daly CM, Lu J, Virkki LV, Pelletier MF and Boron WF. The human NBCe1-A mutant R881C, associated with proximal renal tubular acidosis, retains function but is mistargeted in polarized renal epithelia.

Am. J. Physiol. Cell Physiol. 291; C788-C801, 2006.

5. Parker MD, Young MT, Daly CM, Meech RW, Boron WF and Tanner MJ. A Conductive Pathway Generated From Fragments Of The Human Red Cell Anion Exchanger, AE1.

J. Physiol. 581: 33-50, 2007.

6. Chen L-M, Kelly ML, Rojas JD, Parker MD, Gill HS, Davis BA and Boron WF. Use of a new polyclonal antibody to study the distribution and glycosylation of the sodium-coupled bicarbonate transporter NCBE in rodent brain.

Neuroscience 151: 374–385, 2008.

7. Chen L-M, Kelly ML, Parker MD, Bouyer P, Gill HS, Felie JM, Davis BA and Boron WF. Expression and localization of Na+-driven Cl–HCO3

– exchanger (SLC4A8) in rodent CNS

Neuroscience 153: 162-174, 2008.

8. Parker MD*, Musa-Aziz R*, Rojas JD, Choi I, Daly CM and Boron WF.

Characterization of human SLC4A10 as an electroneutral Na/HCO3 cotransporter (NBCn2) with Cl– self- exchange activity.

J. Biol. Chem. 283: 12777-12788, 2008.

9. Parker MD, Bouyer P, Daly CM and Boron WF.

Cloning and characterization of novel human SLC4A8 gene products encoding Na+-driven Cl-HCO3 exchanger variants NDCBE-A, -C and -D.

Physiological Genomics 34: 265-276, 2008.

10. Liu Y, Xu K, Chen L-M, Sun X, Parker MD, Kelly ML, LaManna JC and Boron WF

Distribution of NBCn2 (SLC4A10) splice variants in mouse brain.

Neuroscience 169; 951-964, 2010.

11. Wu F, Saleem M, Ni L, Kampik NB, Toth T, Williamson R, White G, Young MT, Parker

MD, Alper SL, Kretzler M, Wagner CA and Toye AM. Anion exchanger 1 interacts with nephrin in podocytes.

J. Am. Soc. Nephrol. 21: 1456-1467, 2010.

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12. Leviel F, Hübner CA, Houillier P, Morla L, El Moghrabi S, Brideau G, Hatim H, Parker MD, Kurth I, Kougioumtzes A, Sinning A, Pech V , Riemondy KA, Miller RL, Hummler E, Shull GE, Aronson PS, Doucet A, Wall AM, Chambrey R and Eladari D.

The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice.

J. Clin. Invest. 120: 1627-1635, 2010.

13. Zhang K, Yin L, Zhang M, Parker MD, Binder HJ, Salzman P, Zhang L, Okunieff P and Vidyasagar S.

Radiation decreases murine small intestinal HCO3− secretion.

Int. J. Radiat. Biol. 87: 878-888, 2011.

14. Valente M, Watterson SJ, Parker MD, Ford RC and Young MT.

Expression, purification, electron microscopy, N-glycosylation mutagenesis and molecular modeling of human P2X4 and Dictyostelium discoideum P2XA.

Biochim. Biophys. Acta 1808: 2859-2866, 2011.

15. Lee SK, Boron WF and Parker MD. Relief of autoinhibition of the electrogenic Na/HCO3 cotransporter NBCe1-B: role of IRBIT vs. amino-terminal truncation.

Am. J. Physiol. Cell Physiol. 302: C518-C526, 2012.

16. Parker MD, Qin X, Williamson RC, Toye AM and Boron WF.

HCO3–-independent conductance with a mutant Na/HCO3 cotransporter (SLC4A4) in

a case of proximal renal tubular acidosis with hypokalemic paralysis.

J. Physiol. 590: 2009-2034, 2012.

17. Lee SK, Boron WF and Parker MD.

Substrate specificity of the electrogenic sodium/bicarbonate cotransporter NBCe1-A (SLC4A4, variant A) from humans and rabbits.

Am. J. Physiol. Renal 304: 883-899, 2013. (Editor’s Pick July 2013)

18. Danielsen AA*, Parker MD*, Lee S-J, Boron WF, Aalkjaer C, and Boedtkjer E

Splice cassette II of NBCn1 (slc4a7) interacts with calcineurin A: implications for transporter activity and intracellular pH control during rat artery contractions. (*shared first authorship)

J. Biol. Chem. 288: 8146-8155, 2013.

19. Liu Y, Qin X, Wang DK, Guo YM, Gill HS, Morris N, Parker MD, Chen LM and Boron WF.

Effects of optional structural elements, including two alternative amino termini and a new splicing cassette IV, on the function of NBCn1 (SLC4A7).

J. Physiol. 591: 4983-5004, 2013.

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20. Geyer RR, Parker MD, Toye AM, Boron WF and Musa-Aziz R. Relative CO2/NH3 permeabilities of human RhAG, RhBG and RhCG.

J. Membr. Biol. 246: 915-926, 2013.

21. Khan S, Jawdeh BG, Goel M, Schilling WP, Parker MD, Puchowicz MA, Yadav SP, Harris

RC, El-Meanawy A, Hoshi M, Shinlapawittayatorn K, Deschenes I, Ficker E and Schelling JR.

Lipotoxic disruption of NHE1 interaction with PI(4,5)P2 expedites proximal tubule apoptosis

J. Clin. Invest. 124: 1057-1068, 2014.

22. Jalali R, Guo J, Zandieh-Doulabi B, Bervoets TJ, Paine ML, Boron WF, Parker MD,

Bijvelds MJ, Medina JF, DenBesten PK and Bronckers AL. NBCe1 (SLC4A4) a potential pH regulator in enamel organ cells during enamel development in the mouse.

Cell. Tissue Res. 358: 433-442, 2014.

23. Schmandt N, Velisetty P, Chalamalasetti SV, Stein RA, Bonner R, Talley L, Parker MD, Mchaourab HS, Yee V, Lodowski DT and Chakrapani S.

A Chimeric Prokaryotic Pentameric Ligand-Gated Channel reveals Distinct Pathways of Activation.

J. Gen. Physiol. 146: 323-340, 2015.

24. Wang D-K, Liu Y, Myers EJ, Guo Y-M, Xie Z-D, Jiang D-Z, Li J-M, Yang J, Liu M, Parker

MD and Chen L-M. Effects of Nt truncation and coexpressing isolated Nt domain on membrane trafficking if the electroneutral Na+/HCO3

− cotransporters.

Sci. Rep. 5: 12241, 2015.

[Impact Factor 5.2. We performed the electrophysiology measurements for this manuscript.]

25. Myers EJ, Yuan L, Felmlee MA, Lin YY, Jiang Y, Pei Y, Wang O, Li M, Xing XP, Marshall

A, Xia WB, and Parker MD. A novel mutant Na+/HCO3

− cotransporter NBCe1 in a case of compound-heterozygous inheritance of proximal renal tubular acidosis.

J. Physiol. 594: 6267-6286, 2016.

26. Myers EJ, Marshall AM, Jennings ML, and Parker MD.

Mouse Slc4a11 expressed in Xenopus oocytes is an ideally selective H+/OH− conductance pathway that is stimulated by rises in intracellular and extracellular pH

Am. J. Physiol: Cell Physiol. 311: 945-959, 2016.

[Our manuscript was selected to be the subject of an editorial in AJP: Cell “H(OH), H(OH), H(OH): a holiday perspective.” by Keith Nehrke]

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27. Schlader Z, Chapman CL, Sarker S, Russo L, Rideout TC, Parker MD, Johnson BD, and Hostler D.

Firefighter work duration influences the extent of acute kidney injury.

Med. Sci. Sports Exerc. (In press 2017).

28. Jones RS, Parker MD, and Morris M.

Flavanoids are inhibitors of Monocarboxylate Transporter 6.

Mol. Pharmaceut. (In press 2017).

Contributions to books

1. Parker MD and Boron WF. Sodium-Coupled Bicarbonate Transporters.

In Seldin and Giebisch’s The Kidney: Physiology and Pathophysiology, edited by RJ Alpern and SC Hebert, Philadelphia: Elsevier, 2007.

2. Boron WF and Parker MD. Bicarbonate physiology and pathophysiology.

McGraw-Hill Yearbook of Science and Technology 2013, (published Dec 2012).

Scholarly reviews 1. Groves JD, Parker MD, Askin D, Falson P, le Maire M and Tanner MJ. Heterologous expression of the red-cell anion exchanger (band 3; AE1)

Biochem. Soc. Trans. 27: 917-923, 1999.

2. Boron WF, Chen LM and Parker MD. Modular structure of sodium-coupled bicarbonate transporters.

J. Exp. Biol. 212: 1697-1706, 2009.

3. Musa-Aziz R, Boron WF, and Parker MD. Using fluorometry and ion-sensitive microelectrodes to study the functional expression of heterologously-expressed ion channels and transporters in Xenopus oocytes.

Methods 51: 134-145, 2010.

4. Lee SK, Boron WF and Parker MD. Monitoring ion activities in and around cells using ion-selective liquid-membrane microelectrodes.

Sensors 13: 984-1003, 2013.

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5. Romero MF, Chen A-P, Parker MD and Boron WF. The SLC4 family of bicarbonate (HCO3

−) transporters.

Mol. Aspects Med. 34: 159-182, 2013.

6. Parker MD and Boron WF. The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters.

Physiol. Rev. 93: 803-959, 2013.

7. Ruffin VA, Salameh AI, Boron WF and Parker MD. Intracellular pH regulation by acid-base transporters in mammalian neurons.

Front. Physiol. 5: 43, 2014.

8. Parker MD, Myers EJ, Schelling JR. Na+-H+ exchanger-1 (NHE1) regulation in kidney proximal tubule.

Cell. Mol. Life Sci. 72: 2061-74, 2015.

9. Patel SP and Parker MD. SLC4A11 and the pathophysiology of congenital hereditary endothelial dystrophy.

Biomed. Res. Int. Article ID: 475392. 2015.

Letters to the editor

1. Parker MD, Musa-Aziz RA and Boron WF. The use of extracellular, ion-selective microelectrodes to study the function of heterologously expressed transporters in Xenopus oocytes.

Am. J. Physiol. Cell Physiol. 296: C1243, 2009.

Media Presentations

1. Parker MD.

NBCe1-A substrate specificity.

Am. J. Physiol. Renal Podcast. April 2013. http://ajprenal.podbean.com/e/nbce1-a-substrate-specificity/

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Meeting Abstracts (since 2011)

1. Geyer RR, Parker MD, Burton N, Boron WF, Toye AM, and Musa-Aziz R. Relative CO2/NH3 permeabilities of human RhAG, RhBG, and RhCG.

FASEB J. 25: 1040.4. 2011.

2. Parker MD and Boron WF. Unusual transport modes of the Na+-coupled HCO3

- transporters NDCBE (SLC4A8) and NBCn2 (SLC4A10) in the absence of extracellular Cl-.

FASEB J. 25: 656.3. 2011.

3. Parker MD, Wass AB, Lee SK, Rahman F, Grant C, and Boron WF. Functional reassembly of NBCe1-A from co-expressed cytosolic and transmembrane domains.

FASEB J. 26: 882.2. 2012.

4. Moss FJ, Lee SK, Parker MD, and Boron WF. Distinguishing HCO3

- from CO3= transport by the electrogenic Na/HCO3 cotransporter

NBCe1 (SLC4A4)

FASEB J. 28: 1098.7. 2014.

5. Musa-Aziz R, Parker MD, Moss FJ, and Boron WF. Direction-dependent block of an electroneutral Na/HCO3 cotransporter: insights from simultaneous intracellular and surface pH measurements in the presence of DIDS

JASN. 25: 382A. 2014.

6. Geyer RR, Zhao P, Parker MD, and Boron WF. A novel assay for quantifying carbonic anhydrase activity and assessing red blood cell hemolysis

JASN. 25: 382A. 2014.

7. Myers EJ, Yuan L, Felmlee MA, Lin Y-Y, Jiang Y, Pei Y, Wang O, Li M, Xing X-P, Marshall A, Xia W-B, and Parker MD.

A novel missense mutation in the NBCe1 gene (SLC4A4) and a novel mode of inheritance for proximal renal tubular acidosis

FASEB J. 29: 809.24. 2015.

8. Brotzki C, Marshall A, Jennings ML, Patel SP and Parker MD. The mammalian bicarbonate transporter related protein BTR1 (Slc4a11) promotes boron accumulation in yeast.

FASEB J. 29: 845.23. 2015.

Mark D Parker

19

9. Moss FJ, Zeise B, Parker MD, YU B, Morrison AC, and Boron WF. Extreme blood pressure mutations in NBCn1 influence bicarbonate-independent conductance but not Na/HCO3 cotransport activity.

FASEB J. 30: 968.12. 2016.

10. Myers EJ, Marshall A, and Parker MD. Mouse Slc4a11 mediates extracellular-pH-sensitive H+-conduction in Xenopus oocytes.

FASEB J. 30: 971.6. 2016.

[Published as full manuscript in 2016]

11. Myers EJ, Patel SP, Marshall A, Jennings ML, and Parker MD. Acidic eye-drops de-swell the edematous corneas of Slc4a11-null mice; Evidence for functional coupling between Slc4a11 and the H+/lactate cotransporter Mct1.

FASEB J. 30: 971.7. 2016.

12. Myers EJ, Marshall A, and Parker MD. Normal intrinsic Na/HCO3 cotransport activity but altered plasma membrane abundance of phosphomimetic NBCe1-A mutants.

JASN 27: 650A. 2016.

13. Salerno EE, Patel SP, Marshall A, Mballo CSA, and Parker MD. NBCe1-B/C knockout mice exhibit signs associated with proximal renal tubular acidosis.

FASEB J. 31: 1007.29. 2017.

14. Parker MD, Patel SP, Marshall A, Mballo CSA, and Salerno EE. A novel model of corneal edema in mice with a disrupted endothelial bicarbonate transporter.

IOVS 58: 5665. 2017.

Mark D Parker

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School news about our laboratory

August 2015: “Parker Receives Award from American Society of Nephrology”

http://medicine.buffalo.edu/news_and_events/news.host.html/content/shared/smbs/news/2015/

08/parker-asn-award-5036.detail.html

April 2016: “Graduate Student in Physiology Program Wins Prestigious Award”

http://medicine.buffalo.edu/news_and_events/news.host.html/content/shared/smbs/news/2016/

04/myers-slc4a11-blindness-5870.detail.html

December 2016: “Parker Leads Research with New Clues to Protein’s Role in Corneal

Disease”

https://medicalxpress.com/news/2016-12-elusive-protein-ph-imbalance-acid.html

January 2017: “Research Provides Fresh Clues to Protein’s Role in Corneal Disease”

http://medicine.buffalo.edu/news_and_events/news.host.html/content/shared/smbs/news/2017/

01/parker-protein-corneal-disease-6447.detail.html