Materials and MethodsPhase 1

• Evaluated acute effects on fasting blood glucose and on post-oral glucose

• Groups 1 and 3 received distilled water• Groups 2 and 4 received cinnamon extracts• All groups fasted for 12 hours overnight and

blood glucose levels were measured fasting and post-oral glucose load– This cycle was repeated 3 times to obtain mean

blood glucose values

Cinnamon Extract Preparation

• Dosage for rats calculated according to body surface area

• Daily cinnamon dose for a 200g rat was 120mg in 1 ml of distilled water via a metal oro-gastric tube

• Dose(mg/kg)= Human dose (mg/kg) x [human factor/Rat factor]

Results

• No statistically significant difference in mean body weight and mean blood glucose levels at each hour of groups 1 and 2

• Only the cinnamon administered group demonstrated a greater mean percentage difference at 0.5, 1 and 2 hour, but was still not statistically significant.

• Comparing groups 3 and 4 at 0.5 hour, group 4 demonstrated a faster decline in blood glucose.

Results Continued

• The mean percentage reduction in blood glucose from 0.5 to 1 hour in groups 3 and 4 were 7.7% and 27.7% respectively.

• The cinnamon group also demonstrated a lower blood glucose value at 8 and 12 hours post oral glucose load

Fasting and Post-oral glucose load levels

.5, 8, and 12 hours were all statistically significant

Groups 1 and 2 Results

• There was no statistical difference between Groups 1 and 2 on fasting blood glucose

Groups 3 and 4 Results

• Group 3 (distilled water) declined slower than Group 4 (cinnamon extract)

Materials and MethodsPhase II

• Evaluated the effects on food consumption, body weight, blood glucose, and lipids over 1 month

• 4 different groups: – Healthy rats

• Group A: 8 subjects, distilled water• Group B: 8 subjects, cinnamon extracts

– Diabetes induced rats• Group C: 5 subjects, distilled water• Group D: 5 subjects, cinnamon extracts

Diabetes Induction

• Groups C and D were induced with diabetes by a single intravenous injection of streptozotocin to the tail vein at a dose of 75 mg/kg body weight

• Tests were performed 14 days after injection to confirm and rats with a fasting blood glucose of >200mg/dl were allocated to Groups C and D

Results: Body weight and Food Consumption (Groups A & B)

• The mean weight of the control group increased significantly (Group A) in comparison with Group B.

• Mean food consumption of both Groups A and B had no significant difference between day 0 and day 30

Results: Body Weight and Food Consumption (Groups C & D)

• The weight reduction in both Groups C & D were not statistically significant

• Mean food consumption in Group D (cinnamon group) significantly reduced from day 0 to 30

• Mean food consumption in Group C (distilled water) did not significantly reduce

Results: Mean Food Consumption

• Mean food consumption during study period (A) in healthy animals and (B) in diabetes induced

Results: Blood Glucose

• No statistical difference in healthy rats on fasting blood glucose levels and the 2 hour post-prandial blood glucose.

• In the diabetes induced animals, the fasting blood glucose was significantly lower in the cinnamon group on day 20 and 30.

• Also in the diabetes induced animals the 2 hours post-prandial blood glucose was significantly lower on day 30 in the cinnamon group

Results: Lipids

• In both healthy and diabetes induced animals, the cinnamon group showed significantly lower total in LDL cholesterol levels on day 30 compared to day 0.

• This difference was not observed in the control groups (Groups 1 & 3)

• HDL cholesterol and triglycerides remained unchanged in all 4 groups