mbio.asm.org · Web viewCPA2; likely carbamoyl-phosphate synthase large subunit similar to S. cerevisiae CPA2 (YJR109C) invovled in arginine biosynthesis K03017 CaO19.2276 Replication

Table 3. In vitro C. albicans Biofilm Matrix Proteome

Metabolic Process KEGG Subclass KEGG ID ORF Number Gene NameAmino Acid Metabolism

00340 Histidine Metabolism K00128 CaO19.13228

ALD99; aldehyde dehydrogenase

K00128 CaO19.5806 ALD99; aldehyde dehydrogenase

00310 Lysine Degradation K00128 CaO19.13228



K00626 CaO19.1591

ERG10; similar to Acetoacetyl-CoA Thiolase A; mevalonate/sterol pathway

K00293 CaO19.7448

LYS9; Saccharopine dehydrogenase (NADP+, L-glutamate forming)

K00164 CaO19.6165

KGD1; 2-Oxoglutarate dehydrogenase complex E1 component

00330 Arginine & Proline Metabolism K01915 CaO19.646

GLN1; likely glutamine synthetase similar to S. cerevisiae GLN1 (YPR035W)

K00813 CaO19.6287

AAT2; similar to S. cerevisiae AAT2 (YLR027C) aspartate aminotransferase, cytosolic

K00813 CaO19.3554

AAT1; similar to mammalian mitochondrial aspartate aminotransferase; similar to S. cerevisiae AAT1 (YKL106W)

K00813 CaO19.4669

AAT22; similar to S. cerevisiae AAT2 (YLR027C) aspartate aminotransferase

K00813 CaO19.12139


K00262 CaO19.4716

GDH1; similar to S. cerevisiae NADP-specific glutamate dehydrogenase GDH1 (YOR375C)



K00797 CaO19.2250 SPE3; spermidine synthase

K14454 CaO19.13666


K01476 CaO19.3934

CAR1; likely arginase similar to S. cerevisiae CAR1 (YPL111W) involved in arginine catabolism to ornithine

K00286 CaO19.5650

PRO3; Delta-1-pyrroline-5-carboxylate reductase

K00286 CaO19.13095

PRO3; Delta-1-pyrroline-5-carboxylate reductase

K00819 CaO19.5641 CAR2; Ornithine aminotransferase

K00819 CaO19.13086 CAR2; Ornithine aminotransferase

K00286 CaO19.11750

PUT1; Putative proline oxidase; alkaline upregulated by Rim101p; biofilm-induced

K00813 CaO19.11037 AAT1; Aspartate aminotransferase; soluble protein in hyphae; macrophage-induced protein; alkaline upregulated; amphotericin B repressed; gene used for strain identification by multilocus sequence

typing; farnesol-, Hap43p-induced; GlcNAc-induced

00270 Cysteine & Methionine Metabolism K01758 CaO19.13760

CYS3; cystathionine gamma-lyase

K00813 CaO19.6287


K00813 CaO19.3554


K00813 CaO19.4669


K00813 CaO19.12139


K00003 CaO19.10468 HOM6; homoserine dehydrogenase

K01738 CaO19.7152

CYS4; likely pyridoxal-phosphate dependent enzyme similar to S. cerevisiae YGR012W and CYS4 (YGR155W) cystathionine beta-synthase

K01738 CaO19.5574

similar to putative cysteine synthetase YGR012W; match to pfam pyridoxal-phosphate dependent enzymes


K14454 CaO19.13666


K00789 CaO19.657

SAM2; likely S-adenosylmethionine synthetase similar to S. cerevisiae SAM2 (YDR502C)

K01739 CaO19.8635

STR2; cystathionine synthase

K01739 CaO19.1033


K01739 CaO19.7297

similar to S. cerevisiae YHR112C

K00133 CaO19.1559

HOM1; Aspartate-semialdehyde dehydrogenase; forms a homodimer; conserved in bacteria, archaea, and fungi but not in mammals; ketoconazole-repressed; protein present in exponential and stationary growth phase yeast cultures; GlcNAc-induced protein

K01655 CaO19.11037

AAT1; Aspartate aminotransferase; soluble protein in hyphae; macrophage-induced protein; alkaline upregulated; amphotericin B repressed; gene used for strain identification by multilocus sequence typing; farnesol-, Hap43p-induced; GlcNAc-induced

00300 Lysine Biosynthesis K01655 CaO19.772

LYS212; one of two genes similar to S. cerevisiae LYS21 (YDL131W) homocitrate synthase


K01655 CaO19.11982 LYS211; one of

two genes similar to S. cerevisiae LYS21 (YDL131W) homocitrate synthase

K05824 CaO19.10060

LYS12; homoisocitrate dehydrogenase

K01649 CaO19.4506


K00293 CaO19.7448

LYS9; Saccharopine dehydrogenase (NADP+, L-glutamate forming)

K00133 CaO19.1559

HOM1; Aspartate-semialdehyde dehydrogenase; forms a homodimer; conserved in bacteria, archaea, and fungi but not in mammals; ketoconazole-repressed; protein present in exponential and stationary growth phase yeast cultures; GlcNAc-induced protein

00290 Valine, Leucine & Isoleucine Biosynthesis K00826 CaO19.6994

BAT1; Branched-chain amino acid transaminase

K00826 CaO19.797

BAT2; similar to S. cerevisiae branched-chain amino acid transaminase BAT2 (YJR148W) expressed during stationary phase

K01649 CaO19.13505

alpha-isopropylmalate synthase

K01649 CaO19.4506


K01649 CaO19.1375 leucine biosynthesis

K00161 CaO19.10609

PDA1; alpha subunit of pyruvate dehydrogenase

K00162 CaO19.12753

PDB1; beta subunit of pyruvate dehydrogenase

K00053 CaO19.7733

ILV5; similar to S. cerevisiae ILV5 (YLR355C) mitochondrial ketol-acid reductoisomerase involved in branched chain aa biosynthesis

K01652 CaO19.1613ILV2; Acetolactate synthase

K01687 CaO19.11523

ILV3; Dihydroxyacid dehydratase

00250 Alanine, Aspartate & Glutamate Metabolism K00813 CaO19.6287


K00813 CaO19.3554


K00813 CaO19.4669


K00813 CaO19.12139


K14454 CaO19.13666


K01756 CaO19.3870

ADE13; Adenylosuccinate lyase

K01756 CaO19.11351


K00814 CaO19.7979alanine transaminase

K01939 CaO19.4827

ADE12; Adenylosuccinate synthase

K01939 CaO19.12290

ADE12; Adenylosuccinate synthetase

K00814 CaO19.346alanine transaminase

K13524 CaO19.8474K13524 CaO19.854K13524 CaO19.8421K13524 CaO19.803K00262 CaO19.4716K15371 CaO19.2192K15371 CaO19.9738K14455 CaO19.11037K01955 CaO19.10732K01955 CaO19.3221K01953 CaO19.198 ASN1K01953 CaO19.7828

00280 Valine, Leucine & Isoleucine Degradation K00826 CaO19.6994


K00826 CaO19.797




K00626 CaO19.1591


K00382 CaO19.13546 LPD1; similar to S. cerevisiae LPD1 (YFL018C) dihydrolipoamide dehydrogenase component of 3 multi-enzyme

complexes of the mitochondrial matrix (PDH, OGDH and GCV); FAD flavoprotein

K00632 CaO19.1704K00632 CaO19.7520K00632 CaO19.2046K00632 CaO19.1704K00632 CaO19.2046K00632 CaO19.7520K13524 CaO19.8474K13524 CaO19.854K13524 CaO19.8421K13524 CaO19.803K00020 CaO19.13011K00020 CaO19.5565

00360 Phenylalanine Metabolism K00813 CaO19.6287


K00813 CaO19.3554


K00813 CaO19.4669


K00813 CaO19.12139


K14454 CaO19.13666


K14455 CaO19.1103700350 Tyrosine Metabolism

K00813 CaO19.6287 AAT2; similar to S. cerevisiae AAT2 (YLR027C)

aspartate aminotransferase, cytosolic

K00813 CaO19.3554


K00813 CaO19.4669


K00813 CaO19.12139


K14454 CaO19.13666


K14455 CaO19.1103700260 Glycine, Serine & Threonine Metabolism K00281 CaO19.8015

GCV2; P-subunit of glycine cleavage system

K00281 CaO19.385

GCV2; P-subunit of glycine cleavage system


K01694 CaO19.4718

TRP5; likely tryptophan synthetase alpha chain similar to S. cerevisiae TRP5 (YGL026C)

K00058 CaO19.12728

SER3; similar to S. cerevisiae SER3 (YER081W) 3-phosphoglycerate dehydrogenase; first step in serine biosynthesis

K00600 CaO19.8922

SHM1; serine hydroxymethyl transferase I, similar to S. cerevisiae SHM1 (YBR263W)

K00600 CaO19.13173 SHM2; serine

hydroxymethyl transferase II, similar to S. cerevisiae SHM2 (YLR058C)

K00382 CaO19.13546

LPD1; similar to S. cerevisiae LPD1 (YFL018C) dihydrolipoamide dehydrogenase component of 3 multi-enzyme complexes of the mitochondrial matrix (PDH, OGDH and GCV); FAD flavoprotein

K01733 CaO19.4233 THR4K01733 CaO19.11708K00133 CaO19.1559 HOM2

00400 Phenylalanine, Tyrosine & Tryptophan Biosynthesis K00813 CaO19.6287


K00813 CaO19.3554


K00813 CaO19.4669


K00813 CaO19.12139


K01736 CaO19.1986 ARO2; Chorismate synthase

K14454 CaO19.13666


K01626 CaO19.11542 ARO4; tyrosine-sensitive DAHP

synthase; primary step in aromatic amino acid biosynthesis pathway

K01626 CaO19.1517

ARO3; similar to phenylalanine-sensitive DAHP synthase; primary step in aromatic amino acid biosynthesis pathway

K01694 CaO19.4718

TRP5; likely tryptophan synthetase alpha chain similar to S. cerevisiae TRP5 (YGL026C)

K14455 CaO19.11037K01626 CaO19.11542 ARO4K01626 CaO19.1517

00380 Tryptophan Metabolism K00128 CaO19.13228



K00626 CaO19.1591


K00164 CaO19.6165

KGD1; 2-Oxoglutarate dehydrogenase complex E1 component

Carbohydrate Metabolism

00051 Fructose & Mannose Metabolism K00966 CaO19.6190

VIG9; GDP-mannose pyrophosphorylase similar to S. cerevisiae PSA1 (YDL055C)

K00966 CaO19.12409

PSA1; possible mannose-1-phosphate guanyltransferase

K01803 CaO19.14037

TPI1; similar to S. cerevisiae TPI1 (YDR050C) triose phosphate isomerase; gluconeogenesis

K01803 CaO19.6745 TPI1; similar to S. cerevisiae TPI1

(YDR050C) triose phosphate isomerase; gluconeogenesis

K00844 CaO19.13

GLK2; one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae GLK1 (YCL040W)

K00844 CaO19.1408

GLK3; one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)

K00844 CaO19.734


K00844 CaO19.2154

NAG5; N-acetylglucosamine kinase; recognizes glucose and mannose as substrates; similar to S. cerevisiae HXK1 (YFR053C)

K00844 CaO19.542

HXK2; similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose; similar to S. cerevisiae HXK2 (YGL253W)

K00966 CaO19.6190


K00966 CaO19.12409


00630 Glyoxylate & K00626 CaO19.1591 ERG10; similar to

Dicarboxylate Metabolism

Acetoacetyl-CoA Thiolase A; mevalonate/sterol pathway

K00122 CaO19.638

FDH99; one of three genes similar to S. cerevisiae FDH1 (YOR388C) NAD-formate dehydrogenase

K00122 CaO19.8714


K01637 CaO19.14134

ICL1; isocitrate lyase capable of functionally substituting for S. cerevisiae ICL1 (YER065C); gluconeogenesis

K01638 CaO19.12296

MLS1; malate synthase 1 capable of functionally substituting for S. cerevisiae MLS1 (YNL117W); gluconeogenesis

K00026 CaO19.7481

MDH2; similar to all three S. cerevisiae malate dehydrogenases (YKL085W, YDL078C, YOL126C)

K00026 CaO19.12783

MDH3; similar to S. cerevisiae MDH3 (YDL078C) peroxisomal malate dehydrogenase

K00026 CaO19.12072

MDH1; similar to S. cerevisiae MDH1 (YKL085W) mitochondrial malate dehydrogenase

K00026 CaO19.4602


K00026 CaO19.12072

K00026 CaO19.12783K00026 CaO19.4602K00026 CaO19.7481K01647 CaO19.4393 CIT1K01647 CaO19.11871 CIT1

00500 Starch & Sucrose Metabolism K00693 CaO19.10788

GSY1; UDP-glucose-starch glucosyltransferase

K00697 CaO19.13961

TPS1; trehalose-6-phosphate synthase cloned by functional complementation of a S. cerevisiae tps1 (YBR126C) mutant

K00697 CaO19.12808

TPS3; regulatory subunit of trehalose-6-P synthase/phosphatase

K00697 CaO19.3038

TPS2; trehalose-6-phosphate phosphatase; similar to S. cerevisiae TPS2 (YDR074W) involved in stress response

K01087 CaO19.10556


K00844 CaO19.13


K00844 CaO19.1408


K00844 CaO19.734 GLK1; one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae

Glucokinase GLK1 (YCL040W)

K00844 CaO19.2154


K00844 CaO19.542


K00697 CaO19.13961

TPS1; trehalose-6-phosphate synthase cloned by functional complementation of a S. cerevisiae tps1 (YBR126C) mutant

K00697 CaO19.12808

TPS3; regulatory subunit of trehalose-6-P synthase/phosphatase

K00697 CaO19.3038


K00963 CaO19.1738

UGP1; similar to S. cerevisiae UGP1 (YKL035W) uridinephosphoglucose pyrophosphorylase involved in protein amino acid glycosylation

K01210 CaO19.10469

EXG2; beta-1,3-exoglucanase; cell wall metabolism

K01210 CaO19.12034 BGL2; potential glucosidase similar to S. cerevisiae BGL2 (YGR282C) cell wall endo-beta-1,3-glucan

transferase

K01210 CaO19.10507

XOG1; glucan 1,3-beta-glucosidase similar to S. cerevisiae EXG1 (YLR300W)

K01210 CaO19.2990K01210 CaO19.2990K01210 CaO19.10507K01210 CaO19.12034K01210 CaO19.10469

K00700 CaO19.13067

GLC3; likely glycogen branching enzyme; similar to N. crassa be1 (B8B20.330) and to S. cerevisiae GLC3 (YEL011W); N terminus of this allele is a better match

00053 Ascorbate & Aldarate Metabolism K00128 CaO19.13228



00040 Pentose & Glucuronate Interconversions K00128 CaO19.13228



K05351 CaO19.7676

XYL2; similar to P.stipitis xylitol dehydrogenase (XYL2), and to S. cerevisiae SOR1 (YJR159W) sorbitol dehydrogenase

K00963 CaO19.1738


00052 Galactose Metabolism K00844 CaO19.13


K00844 CaO19.1408


K00844 CaO19.734


K00844 CaO19.2154


K00844 CaO19.542


K00963 CaO19.1738


00562 Inositol Phosphate Metabolism K01803 CaO19.14037


K01803 CaO19.6745


00520 Amino Sugar K00966 CaO19.6190 VIG9; GDP-

& Nucleotide Sugar Metabolism

mannose pyrophosphorylase similar to S. cerevisiae PSA1 (YDL055C)

K00966 CaO19.12409


K00966 CaO19.6190


K00966 CaO19.12409


K00844 CaO19.13


K00844 CaO19.1408


K00844 CaO19.734


K00844 CaO19.2154


K00844 CaO19.542 HXK2; similar to D.occidentalis hexokinase HXK which is able to phosphorylate

glucose and fructose; similar to S. cerevisiae HXK2 (YGL253W)

K01836 CaO19.5013

AGM1; phosphoacetylglucosamine mutase; cloned by complementation of an S. cerevisiae AGM1 (aka PCM1, YEL058W) mutant

K01836 CaO19.12480

AGM1; phosphoacetylglucosamine mutase; cloned by complementation of an S. cerevisiae AGM1 (aka PCM1, YEL058W) mutant

K00963 CaO19.1738


K02564 CaO19.9703

NAG1; C. albicans glucosamine-6-phosphate deaminase (EC 3.5.99.6)

00620 Pyruvate Metabolism K00128 CaO19.13228



K01655 CaO19.11982


K01655 CaO19.772


K00627 CaO19_6561 CaJ7_0184; hypothetical protein

K00627 CaO19.13914

LAT1; dihydrolipoamide acetyltransferase

K01067 CaO19.10681

ACH1; Acetyl-CoA hydrolase/transferase similar to S. cerevisiae mitochondrial ACH1 (YBL015W)

K00626 CaO19.1591


K01649 CaO19.13505

alpha-isopropylmalate synthase

K01649 CaO19.4506


K01649 CaO19.1375 leucine biosynthesis

K00161 CaO19.10609


K01759 CaO19.13479 GLO1; glyoxalase IK01759 CaO19.6058 GLO1; glyoxalase I

K00027 CaO19.10923

MAE1; Mitochondrial malic enzyme

K01638 CaO19.12296

MLS1; malate synthase 1 capable of functionally substituting for S. cerevisiae MLS1 (YNL117W); gluconeogenesis

K01958 CaO19.789

PYC2; likely pyruate carboxylase similar to S. cerevisiae PYC2 (YBR218C) and to Pichia angusta PYC (AAL69566) involved in assembly of peroxisomal alcoholoxidase (AO); N terminal similarity upstream is interrupted

K00162 CaO19.12753


K00026 CaO19.7481


K00026 CaO19.12783


K00026 CaO19.12072


K00026 CaO19.4602


K03678 CaO19.11559K00026 CaO19.7481K00026 CaO19.12072K00026 CaO19.4602K00026 CaO19.12783K00382 CaO19.13546

00650 Butanoate Metabolism K00626 CaO19.1591


K00161 CaO19.10609


K00162 CaO19.12753


K13524K13524K13524K13524


K01652 CaO19.161300030 Pentose Phosphate Pathway

K00033 CaO19.12491 DOR14; similar to S. cerevisiae GND1 (YHR183W) and GND2 (YGR256W)

6-phosphogluconate dehydrogenase; hexose mono-phosphate shunt and pentose phosphate pathways

K01057 CaO19.704

SOL3; similar to S. cerevisiae SOL3 (YHR163W) 6-phosphogluconolactonase involved in tRNA-mediated nonsense suppression and pentose phosphate pathway

K01057 CaO19.1355

SOL2; Multicopy suppressor of los1-1.

K00036 CaO19.4754

ZWF1; likely glucose-6-phosphate dehydrogenase similar to S. cerevisiae ZWF1 (YNL241C)

K00036 CaO19.12218


K00616 CaO19.4371 TAL1; Transaldolase

K00616 CaO19.11849 TAL1; Transaldolase

00020 Citrate Cycle-TCA Cycle K01899 CaO19.10866

LSC1; succinate-CoA ligase

K01958 CaO19.789


K01679 CaO19.543 fumarate hydrataseK01679 CaO19.6724 fumarate hydratase;

corresponds to N-terminus of S.

cerevisiae FUM1; see CaP19.6725

K00234 CaO19.10389

flavoprotein subunit of succinate dehydrogenase

K00234 CaO19.2871

SDH1; flavoprotein subunit of succinate dehydrogenase

K00234 CaO19.440 SDH1; succinate dehydrogenase

K00234 CaO19.8070 succinate dehydrogenase

K00235 CaO19.8251

SDH2; iron-sulfur subunit of succinate dehydrogenase

K00235 CaO19.637

SDH2; iron-sulfur subunit of succinate dehydrogenase

K00627 CaO19.6561 CaJ7_0184; hypothetical protein

K00627 CaO19.13914


K00161 CaO19.10609


K00030 CaO19.13213 IDH2; isocitrate dehydrogenase

K00030 CaO19.5791 IDH2; isocitrate dehydrogenase

K00030 CaO19.12289

IDH1; Mitochondrial isocitrate dehydrogenase1

K00030 CaO19.4826

IDH1; Mitochondrial isocitrate dehydrogenase1

K01958 CaO19.789


K00164 CaO19.6165 KGD1; 2-Oxoglutarate dehydrogenase

complex E1 component

K00162 CaO19.12753


K00026 CaO19.7481


K00026 CaO19.12783


K00026 CaO19.12072


K00026 CaO19.4602


K00382 CaO19.13546

LPD1; similar to S. cerevisiae LPD1 (YFL018C) dihydrolipoamide dehydrogenase component of 3 multi-enzyme complexes of the mitochondrial matrix (PDH, OGDH and GCV); FAD flavoprotein

K00026 CaO19.7481K00026 CaO19.12783K00026 CaO19.12072K00026 CaO19.4602

K01647 CaO19.11871CIT1; nuclear citrate synthase

00010 Glycolysis Gluconeogenesis K00128 CaO19.13228



K01568 CaO19.10395 pyruvate decarboxylase

K01803 CaO19.14037 TPI1; similar to S.

cerevisiae TPI1 (YDR050C) triose phosphate isomerase; gluconeogenesis

K01803 CaO19.6745



K00627 CaO19.13914


K00161 CaO19.10609


K00134 CaO19.14106

TDH1; glyceraldehyde-3-phosphate dehydrogenase (GAPDH), C. albicans cell surface antigen; similar to S. cerevisiae GAPDH proteins encoded by TDH1 (YJL052W), TDH2 (YJR009C) and TDH3 (YJL052W)

K00134 CaO19.6814

TDH1; glyceraldehyde-3-phosphate dehydrogenase (GAPDH), C. albicans cell surface antigen; similar to S. cerevisiae GAPDH proteins encoded by TDH1 (YJL052W), TDH2 (YJR009C) and TDH3 (YJL052W)

K00927 CaO19.11135

PGK1; 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W); gluconeogenesis

K00927 CaO19.3651 PGK1; 3-phosphoglycerate kinase similar to S. cerevisiae PGK1

(YCR012W); gluconeogenesis

K00844 CaO19.13


K00844 CaO19.1408


K00844 CaO19.734


K00844 CaO19.2154


K00844 CaO19.542


K00162 CaO19.12753


K00382 CaO19.13546 LPD1; similar to S. cerevisiae LPD1 (YFL018C) dihydrolipoamide dehydrogenase component of 3 multi-enzyme complexes of the mitochondrial matrix (PDH,

OGDH and GCV); FAD flavoprotein

00640 Propanoate Metabolism K01899 CaO19.10866

LSC1; succinate-CoA ligase



K00626 CaO19.1591


K13524K13524K13524K13524

Cell Growth & Death

04111 Cell Cycle - Yeast K02209 CaO19.12942

CDC46; part of ARS replication initiation complex

K03094 CaO19.4427 SKP1; kinetochore complex


04113 Meiosis - Yeast K06269 CaO19.6285

GLC7; potential calcineurin-like phosphoesterase similar to S. cerevisiae GLC7 (YER133W) protein phosphatase involved in glycogen accumulation

K06269 CaO19.13664


K02209 CaO19.12942


K12761 CaO19.1936

SNF1; protein serine/threonine kinase

K12761 CaO19.9491

SNF1; protein serine/threonine kinase

Energy Metabolism 00190 Oxidative K02147 CaO19.4328 CCC2; copper-

Phosphorylation transporting ATPase

K02266 CaO19.6854

ATP1; C terminus of mitochondrial F1F0 H+ATPase; two introns and exons upstream

K02266 CaO19.5419

ATP5; similar to S. cerevisiae ATP5 (YDR298C) mitochondrial ATP synthase subunit, oligomycin sensitivity-conferring protein

K00413 CaO19.3167 COX10; putative farnesyl transferase

K00413 CaO19.10676 COX10; putative farnesyl transferase

K00417 CaO19.9042

COX13; subunit 6a of cytochrome c oxidase

K00417 CaO19.1467

COX13; subunit 6a of cytochrome c oxidase

K02136 CaO19.3757

ATP20; protein associated with mitochondrial ATP synthase

K02136 CaO19.7996

VMA6; vacuolar hydrogen-transporting ATPase VO domain

K02136 CaO19.364

VMA6; vacuolar hydrogen-transporting ATPase VO domain

K02149 K03955

NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1

K02133 CaO19.10301

ATP7; ATP synthase d subunit, energy generation

K02133 CaO19.11241

ATP20; protein associated with mitochondrial ATP synthase

K00234 CaO19.4016

COR1; part of ubiquinol cyt-c reductase complex

K00234 CaO19.11499

COR1; part of ubiquinol cyt-c reductase complex

K00234 CaO19.2644 QCR2; similar to S.

cerevisiae QCR2 (YPR191W) ubiquinol cyt-c reductase core protein 2

K00235 CaO19.5629

QCR7; Ubiquinol cytochrome-c reductase subunit 7

K02132 CaO19.806

VMA7; Vacuolar H(+)-ATPase (V-ATPase)

K02145 CaO19.12838 PMA1; adenosine triphosphatase

K02134 CaO19.2785

ATP7; ATP synthase d subunit, energy generation

K02138 CaO19.4954

PPA1; Proteolipid - vacuolar ATPase V0 domain subunit c''

K02138 CaO19.12419

PPA1; c subunit of V0 domain of V-ATPase

K03950 CaO19.1872 hypothetical protein

K03950 CaO19.5547

potential mitochondrial NADH-ubiquinone oxidoreductase Complex I, LYR protein domain similar to human B22, NDUFB9 subunit

K02263 CaO19.13098

ATP2; beta subunit of mitochondrial F1F0-ATPase

K02263 CaO19.10734

ATP3; likely ATP synthase similar to S. cerevisiae ATP3 (YBR039W) gamma subunit of F1-ATP synthase

K03935 CaO19.6794

potential mitochondrial NADH-Ubiquinone Oxidoreductase Complex I subunit similar to Y.lipolytica NUKM subunit and mammalian PSST, CI-20kd or NDUFS7 subunit

K03935 CaO19.12222 potential mitochondrial

NADH-Ubiquinone Oxidoreductase Complex I subunit similar to Y.lipolytica NUIM subunit, N. crassa CI-23kd subunit and mammalian TYKY 23kd subunit

K00234 CaO19.440K00234 CaO19.440

00910 Nitrogen Metabolism K00413 CaO19.3527

CYT1; likely cytochrome C1 similar to S. cerevisiae CYT1 (YOR065W) mitochondrial electron transporter

K00413 CaO19.11011

CYT1; N terminal fragment of CaP19.3527, likely cytochrome C1

K03522 CaO19.2150

electron transfer flavoprotein alpha subunit

K15371 CaO19.2192K15371 CaO19.9738K15371 CaO19.4716K01953 CaO19.198 ASN1K01953 CaO19.7828 ASN1

00680 Methane Metabolism K00122 CaO19.638


K00122 CaO19.8714


K00863 CaO19.4777

DAK2; dihydroxyacetone kinase

K00863 CaO19.12241


K01070 CaO19.6596 similar to S-formylglutathione hydrolase involved in formaldehyde catabolism; esterase

motif

K00058 CaO19.12728

SER3; similar to S. cerevisiae SER3 (YER081W) 3-phosphoglycerate dehydrogenase; first step in serine biosynthesis

K00600 CaO19.8922


K00600 CaO19.13173

SHM2; serine hydroxymethyl transferase II, similar to S. cerevisiae SHM2 (YLR058C)

00920 Sulfur Metabolism K01738 CaO19.7152

CYS4; likely pyridoxal-phosphate dependent enzyme similar to S. cerevisiae YGR012W and CYS4 (YGR155W) cystathionine beta-synthase

K01738 CaO19.5574

similar to putative cysteine synthetase YGR012W; match to pfam pyridoxal-phosphate dependent enzymes

K01739 CaO19.8635


K01739 CaO19.1033


K01739 CaO19.7297


Folding, Sorting & Degradation 03050 Proteasome K02736 CaO19.11705

PRE4; endopeptidase subunit of proteasome


K03028 CaO19.4956 RPN1; similar to S. cerevisiae RPN1 (YHR027C) subunit of the 19S regulatory particle of the 26S

proteasome

K03028 CaO19.12421

RPN1; similar to S. cerevisiae RPN1 (YHR027C) subunit of the 19S regulatory particle of the 26S proteasome

K03030 CaO19.7264

RPN11; similar to S. cerevisiae RPN11 (YFR004W) deubiquitinylating metalloisopeptidase subunit of the 19S regulatory particle of the 26S proteasome


K02727 CaO19.13935

PRE10; yeast proteasome subunit YC1

K02728 CaO19.7983 PRE9; proteasome component

K02728 CaO19.350 PRE9; proteasome component

K02737 CaO19.9775 PRE2; proteasome subunit

K02737 CaO19.2233 PRE2; proteasome subunit

K03066 CaO19.3593

RPT6; likely ATPase similar to S. cerevisiae RPT6 (YGL048C) ATPase subunit of the 19S regulatory particle of the 26S proteasome

K03061 CaO19.441

RPT1; likely ATPase similar to S. cerevisiae RPT1 (YKL145W) ATPase subunit of the 19S regulatory particle of the 26S proteasome

K03061 CaO19.8071

RPT1; likely ATPase similar to S. cerevisiae RPT1 (YKL145W) ATPase subunit of the 19S regulatory particle of the 26S proteasome

K03064 CaO19.482 RPT4; likely

ATPase similar to S. cerevisiae RPT4 (YOR259C) ATPase subunit of the 19S regulatory particle of the 26S proteasome

K03064 CaO19.8112

RPT4; likely ATPase similar to S. cerevisiae RPT4 (YOR259C) ATPase subunit of the 19S regulatory particle of the 26S proteasome

K03036 CaO19.8879

RPN6; similar to S. cerevisiae RPN6 (YDL097C) subunit of the 19S regulatory particle of the 26S proteasome

K03036 CaO19.1299

RPN6; similar to S. cerevisiae RPN6 (YDL097C) subunit of the 19S regulatory particle of the 26S proteasome


K02735 CaO19.8916

PUP3; peptidase, 20S proteasome subunit, protein degradation

K03062 CaO19.5440

RPT2; likely ATPase similar to S. cerevisiae RPT2 (YDL007W) ATPase subunit of the 19S regulatory particle of the 26S proteasome

K03062 CaO19.12895

RPT2; likely ATPase similar to S. cerevisiae RPT2 (YDL007W) ATPase subunit of the 19S regulatory particle of the 26S proteasome

K03038 CaO19.3168 RPN8; similar to S. cerevisiae RPN8 (YOR261C) subunit of the 19S

regulatory particle of the 26S proteasome

K03038 CaO19.10677

RPN8; similar to S. cerevisiae RPN8 (YOR261C) subunit of the 19S regulatory particle of the 26S proteasome

04120 Ubiquitin Mediated Proteolysis K04649 CaO19.1085

UBC1; likely ubiquitin-conjugating enzyme similar to S. cerevisiae UBC1 (YDR177W)

K04649 CaO19.8686

UBC1; likely ubiquitin-conjugating enzyme similar to S. cerevisiae UBC1 (YDR177W)

K03178 CaO19.7438 UBA1; ubiquitin-activating enzyme



K10597 CaO19.13386

UFD2; U-box protein similar to S. cerevisiae UFD2 (YDL190C) ubiquitin conjugating factor e4

03018 RNA Degradation K12614 CaO19.6197

DHH1; RNA helicase of DEAD box family

K12614 CaO19.13577

DHH1; RNA helicase of DEAD box family

04122 Sulfur Relay System K14171 CaO19_6470

CaJ7_0281; hypothetical protein

K14171 CaO19.10278

AHP11; one of three genes similar to fungal peroxisomal PMP20 and to S. cerevisiae AHP1 (YLR109W) alkyl hydroperoxide reductase

K14171 CaO19.2762 AHP11; one of three genes similar to fungal peroxisomal PMP20

and to S. cerevisiae AHP1 (YLR109W) alkyl hydroperoxide reductase

K14171 CaO19.13824


K04487 CaO19.7081

SPL1; similar to S. cerevisiae NFS1 (YCL017C) mitochondrial cysteine desulfhydrase involved in biogenesis of Fe/S proteins

04130 SNARE Interactions in Vesicular Transport K08516 CaO19.2974

YKT6; similar to S. cerevisiae VKT6 (YKL196C) synaptobrevin v-SNARE protein, ER_Golgi transport; same as cosmid orf Ca49C10.18

K08516 CaO19.10491

YKT6; similar to S. cerevisiae VKT6 (YKL196C) synaptobrevin v-SNARE protein, ER_Golgi transport; same as cosmid orf Ca49C10.18

K08486 CaO19.1376 SSO2; similar to syntaxin

04141 Protein Processing in Endoplasmic Reticulum K10956 CaO19.6176

SEC61; similar to S. cerevisiae SEC61 (YLR378C) membrane component of ER protein translocation apparatus

K10956 CaO19.412 SSH1; protein translocation

K09490 CaO19.9564 KAR2; heat shock protein

K09490 CaO19.2013 KAR2; similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone

involved in translocation of nascent polypeptides across ER membrane and in nuclear fusion during mating

K10597 CaO19.13386

UFD2; U-box protein similar to S. cerevisiae UFD2 (YDL190C) ubiquitin conjugating factor e4

K12275 CaO19.10549

SEC62; membrane unit of ER protein translocation apparatus

CaO19.12535

C terminus has very weak similarity to S. cerevisiae SAE3 involved in meiotic recombination and to S. pombe swi5 involved in mating type switch


K03283 CaO19.1065

SSA2; Cytoplasmic chaperone; member of the HSP70 family similar to S. cerevisiae SSA2 (YLL024C)

K03283 CaO19.8667


K07953 CaO19.10966

SAR1; likely COPII vesicle coat component similar to S. cerevisiae SAR1 (YPL218W) ARF family GTP binding protein; intron and 5' exon upstream

K03283 CaO19.13724 SSB1; HSP70

K14018 CaO19.12292 DOA1; ubiquitin proteolysis

K14006 CaO19.1254 SEC231; one of three genes similar to S. cerevisiae

SEC23 (YPR181C) cytoplasmic GTPase-activating protein involved in COP II vesicle coat assembly

K13525 CaO19.2340

CDC48; microsomal protein of CDC48 family of ATPases

K03283 CaO19.4980 HSP70; heat shock protein 70

K14017 CaO19.8612 SNL1; integral membrane protein

K10956 CaO19.6176



K10956 CaO19.6176



03060 Protein Export K10956 CaO19.6176



K09490 CaO19.9564 KAR2; heat shock protein

K09490 CaO19.2013

KAR2; similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides across ER membrane and in nuclear fusion during mating


K10956 CaO19.6176


K12275 CaO19.10549

SEC62; membrane unit of ER protein translocation apparatus

Glycan Biosynthesis & Metabolism

00513 Various Types of N-Glycan Biosynthesis K12667 CaO19.10578

SWP1; oligosaccharyltransferase delta subunit

00510 N-Glycan Biosynthesis K00721 CaO19.12539

DPM1; likely glycosyltransferase similar to S. cerevisiae DPM1 (YPR183W) ER dolichol phosphate mannose synthase

00514 Other Types of O-Glycan Biosynthesis K00728 CaO19.5171


K00728 CaO19.4109

PMT4; similar to dolichyl-P-mannose:protein mannosyltransferase involved in mannosylation of serine and threonine residues

K00728 CaO19.11590


K00728 CaO19.3802


K00728 CaO19.11283 PMT6; similar to dolichyl-P-mannose:protein mannosyltransferase involved in

mannosylation of serine and threonine residues

K00728 CaO19.12638


K00728 CaO19.14104


K00728 CaO19.6812


Lipid Metabolism00561 Glycerolipid Metabolism K00128 CaO19.13228



K00863 CaO19.4777


K00863 CaO19.12241


00072 Synthesis & Degradation of Ketone Bodies K00626 CaO19.1591


00100 Steroid Biosynthesis K09831 CaO19.5178


K09831 CaO19.12645

ERG5; cytochrome P450 similar to S. cerevisiae ERG5 (YMR015C) C-22 sterol desaturase; ergosterol synthesis; same as cosmid orf Ca35A5.10c

K00559 CaO19.1631 ERG6; SAM:delta 24-methyltransferase

involved in ergosterol biosynthesis; capable of functional substitution for S. cerevisiae ERG6 (YML008C)

01040 Biosynthesis of Unsaturated Fatty Acids K00232 CaO19.13146

POX105; fatty-acyl coA oxidase, peroxisomal beta-oxidation, similar to C.tropicalis POX5; similar to S. cerevisiae POX1 (YGL205W)

K00232 CaO19.1652

POX104; fatty-acyl coenzyme A oxidase similar to C.tropicalis POX4, linked to POX102; similar to S. cerevisiae POX1 (YGL205W)

K00507 CaO19.12583

OLE1; one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9-fatty acid desaturase; same as cosmid orf Ca41C10.02

K00507 CaO19.5117

OLE1; one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9-fatty acid desaturase; same as cosmid orf Ca41C10.02

00071 Fatty Acid Metabolism K00128 CaO19.13228



K01897 CaO19.7156

FAA23; one of four genes similar to S. cerevisiae fatty acyl-CoA synthetase FAA2 (YER015W); lipid metabolism

K01897 CaO19.7379


K01897 CaO19.7592

FAA4; similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase

K01897 CaO19.272


K00626 CaO19.1591


K00232 CaO19.13146


K00232 CaO19.1652


K00632 CaO19.7520

POT1; similar to C.tropicalis 3-ketoacyl-CoA thiolase A; peroxisomal fatty acid beta-oxidation

K00632 CaO19.2046

POT98; similar to rat 3-ketoacyl-CoA thiolase A; peroxisomal fatty acid beta-oxidation

K00632 CaO19.2046 POT98; similar to rat 3-ketoacyl-CoA thiolase A; peroxisomal fatty

acid beta-oxidation

K00632 CaO19.7520


K00626 CaO19.1591


K00626 CaO19.1591


00592 alpha-Linolenic Acid Metabolism K00232 CaO19.13146


K00232 CaO19.1652


K00632 CaO19.2046


K00632 CaO19.2046


K00632 CaO19.7520


K00632 CaO19.7520


K00632 CaO19.1704

POT2; likely thiolase similar to C.tropicalis 3-ketoacyl-CoA thiolase isoenzymes A and B involved in peroxisomal fatty acid beta-oxidation; similar to S. cerevisiae POT1 (YIL160C)

K00632 CaO19.1704

POT2; likely thiolase similar to C.tropicalis 3-ketoacyl-CoA thiolase isoenzymes A and B involved in peroxisomal fatty acid beta-oxidation; similar to S. cerevisiae POT1 (YIL160C)

00564 Glycerophospholipid Metabolism K00006 CaO19.691

GPD2; one of two genes similar to S. cerevisiae GPD1 (YDL022W) and GPD2 (YOL059W) glycerol-3-phosphate dehydrogenase

K00006 CaO19.1756


K00111 CaO19.10645

GUT2; glycerol-3-phosphate dehydrogenase, mitochondrial

K00006 CaO19.691


K00006 CaO19.1756 GPD1; one of two genes similar to S. cerevisiae GPD1 (YDL022W) and GPD2 (YOL059W)

glycerol-3-phosphate dehydrogenase

K13333 CaO19.6594

PLB4; phospholipase B4; one of five likely phospholipase B-like genes; similar to torulaspora delbruekkii PLB and to S. cerevisiae PLB1 (YMR008C)

K13333 CaO19.690

PLB2; phospholipase B2; second in a tandem pair; similar to Torulaspora delbruekkii PLB and to S. cerevisiae PLB3 (YOL011W); one of five likely phospholipase B-like genes

K13333 CaO19.689

PLB1; phospholipase B1; first in a tandem pair; similar to torulaspora delbruekkii PLB and to S. cerevisiae PLB3 (YOL011W); one of five likely phospholipase B-like genes

K13333 CaO19.5102

PLB5; phospholipase B5; similar to Torulaspora delbruekkii PLB and to S. cerevisiae PLB3 (YOL011W); one of five likely phospholipase B-like genes

K01115 CaO19.1161

SPO14; Phospholipase D:required for commitment to meiosis

K13621 CaO19.1171

similar to S-adenosylmethionine:diacylglycerol 3-amino-3-carboxypropyl transferase

00565 Ether Lipid Metabolism K01115 CaO19.1161


Metabolism of Cofactors & Vitamins

00770 Pantothenate & CoA Biosynthesis K00826 CaO19.6994


K00826 CaO19.797


K00053 CaO19.7733

ILV5; similar to S. cerevisiae ILV5 (YLR355C) mitochondrial ketol-acid reductoisomerase involved in branched chain aa biosynthesis

K01687 CaO19.11523

LV3; Dihydroxyacid dehydratase


K01922 CaO19.7357similar to S. cerevisiae YIL083C

00130 Ubiquinone & Other Terpenoid-Quinone Biosynthesis K06126 CaO19.3058

COQ6; COQ6 monooxygenase, coenzyme Q biosynthesis

K06126 CaO19.10576

COQ6; COQ6 monooxygenase, coenzyme Q biosynthesis

00750 Vitamin B6 Metabolism K06215 CaO19.10464

SNZ99; stationary-phase-induced

K06215 CaO19.2947 SNZ99; stationary-phase-induced

K05275 CaO19.7306

similar to S. cerevisiae YPR127W

K01733 CaO19.4233K01733 CaO19.11708

K00275 CaO19.550PDX3; pyridoxine-P-oxidase

00860 Porphyrin & Chlorophyll Metabolism K00228 CaO19.10321

HEM13; Coproporphyrinogen III oxidase.

K01885 CaO19.7057 similar to S.

cerevisiae YGL245W

K01772 CaO19.1880

HEM15; ferrochelatase; last step of heme synthesis; mitochondrial

00670 One Carbon Pool by Folate K00288 CaO19.7534

MIS1; Mitochondrial C1-tetrahydroflate synthase

K00602 CaO19.492

ADE17; Bifunctional transforymlase/cyclohydrolase; purine biosynthesis

K00602 CaO19.8122


K00600 CaO19.8922


K00600 CaO19.13173


00730 Thiamine Metabolism K04487 CaO19.7081

SPL1; similar to S. cerevisiae NFS1 (YCL017C) mitochondrial cysteine desulfhydrase involved in biogenesis of Fe/S proteins

00790 Folate Biosynthesis K01077 CaO19.8599

PHO8; alkaline phosphatase

K01077 CaO19.12198vacuolar alkaline phosphatase

Metabolism of Other Amino Acids

00480 Glutathione Metabolism K00033 CaO19.12491

DOR14; similar to S. cerevisiae GND1 (YHR183W) and GND2 (YGR256W) 6-phosphogluconate dehydrogenase; hexose mono-phosphate shunt and pentose phosphate pathways

K15428 CaO19.11397

likely metallopeptidase; similar to S. cerevisiae YFR044C


K00036 CaO19.4754


K00036 CaO19.12218


00450 Selenocompound Metabolism K00384 CaO19.11766

TRR1; single gene similar to S. cerevisiae TRR1 (YDR353W) and TRR2 (YHR106W) cytoplasmic and mitochondrial thioredoxin reductases

K00384 CaO19.4290


K01874 CaO19.3950

MSM1; mitochondrial tRNA methionyl-tRNA synthetase similar to S. cerevisiae MSM1 (YGR171C) mitochondrial methionyl-tRNA synthetase

K01874 CaO19.11432

MSM1; mitochondrial tRNA methionyl-tRNA synthetase similar to S. cerevisiae MSM1 (YGR171C) mitochondrial methionyl-tRNA synthetase

K01874 CaO19.11437

MES1; likely tRNA synthetase similar to S. cerevisiae MES1 (YGR264C) cytoplasmic methionyl tRNA synthetase

K01874 CaO19.3955


K01739 CaO19.8635


K01739 CaO19.1033


K01739 CaO19.7297


00460 Cyanoamino & Metabolism K00600 CaO19.8922


K00600 CaO19.13173


00410 beta-Alanine Metabolism K00128 CaO19.13228




K13524K13524K13524K13524

00430 Taurine & Hypotaurine Metabolism K15371 CaO19.9738

GDH2; NAD-glutamate dehydrogenase

K15371 CaO19.2192

GDH2; NAD-glutamate dehydrogenase

00900 Terpenoid Backbone Biosynthesis

K00844 CaO19.2154 NAG5; N-acetylglucosamine kinase; recognizes glucose and

mannose as substrates; similar to S. cerevisiae HXK1 (YFR053C)

K00844 CaO19.542


K00844 CaO19.13


K00844 CaO19.1408


K00844 CaO19.734


K00626 CaO19.1591


K00021 CaO19.1031

HMG1; hydroxymethylglutaryl-CoA reductase (ergosterol biosynthesis)

K01823 CaO19.10291 IDI1; similar to isopentenyl diphosphate isomerase of isoprenoid biosynthetic pathway (MutT/NUDIX domain); similar to

S. cerevisiae IDI1 (YPL117C); N terminus is identical to nonallelic CaP19.4558

Nucleotide Metabolism

00230 Purine Metabolism K00602 CaO19.492


K00602 CaO19.8122


K00940 CaO19.11786

YNK1; Nucleoside diphosphate kinase-like orf

K01756 CaO19.3870


K01756 CaO19.11351


K03006 CaO19.7655

RPO21; RNA polymerase II large subunit

K01951 CaO19.12276GUA1; GMP synthase

K00856 CaO19.5591

K01939 CaO19.4827


K01939 CaO19.12290


00240 Pyrimidine Metabolism K00761 CaO19.10163

FUR1; similar to S. cerevisiae FUR1 (YHR128W) uracil phosphoribosyltransferase involved in regulation of the pyrimidine salvage pathway

K00384 CaO19.11766


K00384 CaO19.4290 TRR1; single gene similar to S.

cerevisiae TRR1 (YDR353W) and TRR2 (YHR106W) cytoplasmic and mitochondrial thioredoxin reductases

K00940 CaO19.11786

YNK1; Nucleoside diphosphate kinase-like orf

K01955 CaO19.10732

CPA2; likely carbamoyl-phosphate synthase large subunit similar to S. cerevisiae CPA2 (YJR109C) invovled in arginine biosynthesis

K01955 CaO19.3221

CPA2; likely carbamoyl-phosphate synthase large subunit similar to S. cerevisiae CPA2 (YJR109C) invovled in arginine biosynthesis

K03017 CaO19.2276

Replication & Repair

03410 Base Excision Repair K04802 CaO19.4616

POL30; PCNA-like orf; DNA polymerase processivity accessory factor

K04802 CaO19.12086


03030 DNA Replication K04802 CaO19.4616


K04802 CaO19.12086


K07466 CaO19.9640

RFA1; similar to single-stranded DNA binding protein involved in DNA-damage repair

K07466 CaO19.2093 RFA1; similar to single-stranded DNA binding

protein involved in DNA-damage repair

K02209 CaO19.12942



03440 Homologous Recombination K07466 CaO19.9640


K07466 CaO19.2093


03420 Nucleotide Excision Repair K04802 CaO19.4616


K04802 CaO19.12086


K07466 CaO19.9640


K07466 CaO19.2093



03430 Mismatch Repair K04802 CaO19.4616


K04802 CaO19.12086


K07466 CaO19.9640


K07466 CaO19.2093



03450 Non-Homologous End-Joining K04799

Signal Transduction

04070 Phosphatidylinositol Signaling System K02183 CaO19.11891

CMD1; likely calmodulin 3' exon; 5' exon upstream of intron; similar to S. cerevisiae CMD1 (YBR109C)

K02183 CaO19.4413

CMD1; likely calmodulin 3' exon; 5' exon upstream of intron; similar to S. cerevisiae CMD1 (YBR109C)

04011 MAPK Signaling Pathway - Yeast K11231 CaO19.3256

SLN1; histidine kinase osmosensor

K11231 CaO19.10766 SLN1; histidine kinase osmosensor

K01759 CaO19.13479 GLO1; glyoxalase IK01759 CaO19.6058 GLO1; glyoxalase I

K04441 CaO19.895

HOG1; MAP kinase involved in osmoregulation; identified by functional complementation of S. cerevisiae hog1 (YLR113W) deletion mutant

K04441 CaO19.8514 HOG1; MAP kinase involved in osmoregulation; identified by functional complementation of S. cerevisiae hog1 (YLR113W)

deletion mutant

Transcription

03022 Basal Transcription Factors K03123 CaO19.4625

TOA2; general RNA polymerase II transcription factor

K03123 CaO19.12095

TOA2; general RNA polymerase II transcription factor

03040 Spliceosome K03283 CaO19.1065


K03283 CaO19.13724 SSB1; HSP70



K03283 CaO19.5513

PRP45; similar to N terminus of SkiP component of the spliceosome

K12845 CaO19.13306

SNU13; similar to highly conserved 15.5 kd RNA binding protein/S. cerevisiae SNU13 (YEL026W) that binds to both spliceosomal U4 snRNA and rRNA processing box C/D snoRNAs

K12845 CaO19.7265

UBP10; potential ubiquitin thiolesterase similar to S. pombe ubp10 (SPBC577.07) and to S. cerevisiae SAD1 (YFR005C) factor involved in assembly of snRNA U4 into U4/U6 snRNP

K12812 CaO19.5647

SUB2; similar to spliceosomal DExD helicase involved in mRNA nuclear export

K12812 CaO19.13092


Translation 03010 Ribosome K02958 CaO19.13348 RPS15; likely

cytosolic ribosomal protein similar to S. cerevisiae RPS15 (YOL040C) small subunit protein S15

K02930 CaO19.7217

RPL4; likely cytosolic ribosomal protein similar to S. cerevisiae RPL4A (YBR031W) and RPL4B (YDR012W) large subunit protein L4

K02989 CaO19.4018

RSM7; potential mitochondrial ribosomal protein similar to S. cerevisiae RSM7 (YJR113C) small subunit protein (E. coli S7)

K02989 CaO19.11501

RSM7; potential mitochondrial ribosomal protein similar to S. cerevisiae RSM7 (YJR113C) small subunit protein (E. coli S7)

K02936 CaO19.2311

RPL8A; one of two genes for likely cytosolic ribosomal protein similar to S. cerevisiae RPL8A (YLL045C) and RPL8B YHL033C) large subunit protein L8

K02936 CaO19.9847

RPL8A; one of two genes for likely cytosolic ribosomal protein similar to S. cerevisiae RPL8A (YLL045C) and RPL8B YHL033C) large subunit protein L8

K02936 CaO19.6002 RPL8B; one of two genes for likely cytosolic ribosomal protein similar to S. cerevisiae RPL8A (YLL045C) and RPL8B YHL033C) large subunit protein

L8

K02936 CaO19.13423

RPL8B; one of two genes for likely cytosolic ribosomal protein similar to S. cerevisiae RPL8A (YLL045C) and RPL8B YHL033C) large subunit protein L8

K02951 CaO19.14077

RPS12; likely cytosolic ribosomal protein similar to S. cerevisiae RPS12 (YOR369C) small subunit protein S12

K02951 CaO19.6785

RPS12; likely cytosolic ribosomal protein similar to S. cerevisiae RPS12 (YOR369C) small subunit protein S12

K02995 CaO19.14162

RPS8; likely cytosolic ribosomal protein similar to S. cerevisiae RPS8A (YBL072C) and RPS8B (YER102W) small subunit protein; likely intron in 5' UTR

K02975 CaO19.6663

RPS25; likely cytosolic ribosomal protein similar to S. cerevisiae RPS25A (YGR027C) small subunit protein S25

K02985 CaO19.13689

RPS3; likely cytosolic ribosomal protein similar to S. cerevisiae RPS3 (YNL178W) small subunit protein S3

K02894 CaO19.10998

RPL23; probable Ribosomal Protein L23 similar to S. cerevisiae RPL23A (YBL087C) and RPL23B (YER117W); likely intron and 5' exon upstream

K02883 CaO19.13403 RPL18; similar to C terminus of S.

cerevisiae RPL18A (YOL120C) and RPL18B (YOL120C); intron and 5' exon upstream

K02865 CaO19.10969

RPL1; likely ribosomal protein L1; similar to S. cerevisiae cytosolic large ribosomal subunit component RPL1A (YPL220W) and RPL1B (YGL135W)

K02991 CaO19.12130

RPS6; likely cytosolic ribosomal protein similar to S. cerevisiae RPS6A (YPL090C) and RPS6B (YBR181C) small subunit protein S6; short 5' exon upstream of intron

K02976 CaO19.1470

RPS26; likely cytosolic ribosomal protein similar to S. cerevisiae RPS26A (YGL189C) and RPS26B (YER131W) small subunit protein S26

K02974 CaO19.5466

RPS24; likely cytosolic ribosomal protein similar to S. cerevisiae RPS24A (YER074W) and RPS24B (YIL069C) small subunit protein S24

K02974 CaO19.12921

RPS24; likely cytosolic ribosomal protein similar to S. cerevisiae RPS24A (YER074W) and RPS24B (YIL069C) small subunit protein S24

K02870 CaO19.1635 RPL12; similar to S. cerevisiae RPL12B (YDR418W) and RPL12A

(YEL054C) genes for cytosolic large subunit ribosomal protein L12

K02925 CaO19.1601

RPL3; likely cytosolic ribosomal protein similar to S. cerevisiae RPL3 (YOR063W) large subunit protein L3

K02981 CaO19.10845

RPS2; likely cytosolic ribosomal protein similar to S. cerevisiae RPS2 (YGL123W) small subunit protein S2

K02981 CaO19.3334

RPS2; likely cytosolic ribosomal protein similar to S. cerevisiae RPS2 (YGL123W) small subunit protein S2

K02866 CaO19.10452

RPL10; likely cytosolic ribosomal protein similar to S. cerevisiae RPL10 (YLR075W) large subunit protein L10

K02997 CaO19.8459

RPS9; potential cytosolic ribosomal protein similar to S. cerevisiae RPS9B (YBR189W) and RPS9A (YPL081W) small subunit protein S9 (E. coli S4); intron upstream, but frameshifted twice; allelic position on Ctg19-10076 better matches the S. cerevisiae gene

K02943 CaO19.5928

RPP2B; cytosolic ribosomal large subunit acidic protein P2B similar to S. cerevisiae RPP2B (YDR382W); aka CARP2B

K02943 CaO19.13349 RPP2B; cytosolic ribosomal large subunit acidic protein P2B similar

to S. cerevisiae RPP2B (YDR382W); aka CARP2B

K02984 CaO19.3002

RPS10; Ribosomal Protein 10, similar to S. cerevisiae RPS1B (YML063W) and RPS1A (YLR441C) cytosolic ribosomal small subunit protein S1

K02984 CaO19.10520

RPS10; Ribosomal Protein 10, similar to S. cerevisiae RPS1B (YML063W) and RPS1A (YLR441C) cytosolic ribosomal small subunit protein S1

K02964 CaO19.7018

RPS18; likely cytosolic ribosomal protein similar to S. cerevisiae RPS18A (YDR450W) small subunit protein S18A; 5' exon upstream of intron

K02987 CaO19.12801

RPS41; one of two genes for cytosolic ribosomal protein S4 (formerly S7) - this one has no intron; similar to S. cerevisiae RPS4A (YJR145C) and RPS4B (YHR203C) small subunit protein S4

K02880 CaO19.11966

RPL17; likely cytosolic ribosomal protein similar to S. cerevisiae RPL17B (YJL177W) large subunit protein L17

K02880 CaO19.4490

RPL17; likely cytosolic ribosomal protein similar to S. cerevisiae RPL17B (YJL177W) large subunit protein L17

K02937 CaO19.11348 RLP7; similar to S. cerevisiae RLP7

(YNL002C) nucleolar protein that resembles ribosomal protein L7 but is involved in rRNA maturation

K02977 CaO19.10599

UBI3; ubiquitin-ribosomal protein fusion that gives rise to cytoplasmic ribosomal small subunit protein S27a; can functionally substitute for S. cerevisiae RPS31 (YLR167W); has N terminal extension of 42 amino acids compared to EMBL sequence (CAA75692)

K02993 CaO19.1700

RPS7; likely cytosolic ribosomal protein similar to S. cerevisiae RPS7A (YOR096W) and RPS7B (YNL096C) small subunit protein S7

K02989 CaO19.11812

RPS5; likely cytosolic ribosomal protein similar to S. cerevisiae RPS5 (YJR123W) small subunit protein S5

K02989 CaO19.4336

RPS5; likely cytosolic ribosomal protein similar to S. cerevisiae RPS5 (YJR123W) small subunit protein S5

K02940 CaO19.236

RPL9; likely cytosolic ribosomal protein similar to S. cerevisiae RPL9A (YGL147C) and RPL9B (YNL067W) large subunit protein L9

K02877 CaO19.493 RPL15; likely cytosolic ribosomal protein similar to S. cerevisiae RPL15B (YMR121C) large

subunit protein L15

K02932 CaO19.13894

RPL5; likely cytosolic ribosomal protein similar to S. cerevisiae RPL5 (YPL131W) large subunit protein L5

K02868 CaO19.2232

RPL11; likely cytosolic ribosomal protein similar to S. cerevisiae RPL11A (YPR102C) and RPL11B (YGR085C) large subunit protein L11

03008 Ribosome Biogenesis in Eukaryotes K11128 CaO19.8757

GAR1; Small nucleolar RNP protein

K11128 CaO19.1164

GAR1; small nucleolar RNP protein

K12845 CaO19.5885


K12845 CaO19.13306


K14565 CaO19.1199

NOP58; similar to S. cerevisiae NOP58 (YOR310C) component of Box C/D snoRNPs; 2'-O-methylation of rRNA

K14565 CaO19.8790 NOP58; similar to S. cerevisiae NOP58 (YOR310C) component of Box C/D snoRNPs; 2'-O-

methylation of rRNA

K14290 CaO19.7483

CRM1; Chromosome region maintenance protein

K14564 CaO19.7569

SIK1; similar to S. cerevisiae SIK1 (YLR197W) nucleolar component of Box C/D snoRNPs; 2'-O-methylation of rRNA

K07936 CaO19.5493

GSP1; Ran, Ras family GTP-binding protein; can functionally substitute for S. cerevisiae GSP1 (YLR293C)

K07936 CaO19.12948


K14563 CaO19.3138 NOP1; similar to human fibrillarin

K14563 CaO19.10650 NOP1; similar to human fibrillarin

K14572 CaO19.12161

MDN1; similar to N terminus of midasin-like orf; highly conserved, putative nuclear chaperone; contains tandem repeats of AAA ATPase family repeats and a C terminal MIDAS (Metal Ion Dependent Adhesion Site) motif

K14572 CaO19.12167

similar to S. cerevisiae YLR106C

K14572 CaO19.4697 MDN1; similar to midasin, highly conserved, putative nuclear chaperone; contains tandem repeats of AAA ATPase family

repeats and a C terminal MIDAS (Metal Ion Dependent Adhesion Site) motif; largest orf in C. albicans

00970 Aminoacyl-tRNA Biosynthesis K01874 CaO19.10477

FRS2; phenylalanyl-tRNA synthetase

K01874 CaO19.2960

FRS2; phenylalanyl-tRNA synthetase

K01874 CaO19.2039 phenylalanine--tRNA ligase

K01887 K01887 arginyl-tRNA synthetase


K04567 K04567 lysyl-tRNA synthetase, class II

K01874 CaO19.11437


K01892 CaO19.4051HTS1; histidyl-tRNA synthetase

K01869 CaO19.10094

similar to N terminus of S. cerevisiae CDC60 (YPL160W) cytosolic leucyl tRNA synthetase; see CaP19.10092; both alleles are frameshifted in Assembly 19

K01870 CaO19.2138

ILS1; probable tRNA synthetase similar to S. cerevisiae ILS1 (YBL076C) Isoleucyl-tRNA synthetase, cytoplasmic

K01893 CaO19.13994

DED81; asparaginyl-tRNA synthetase

K01893 CaO19.6702

DED81; asparaginyl-tRNA synthetase

03015 mRNA K14396 CaO19.1389 SGN11; RRM-

Surveillance Pathway

containing orf similar to S. cerevisiae cytoplasmic polyA binding protein

K14396 CaO19.7097

SGN12; second version of cytoplasmic polyA binding protein; more similar to S. pombe version

K06269 CaO19.6285


K06269 CaO19.13664


K03265 CaO19.3541 SUP45; translation release factor eRF1

K03265 CaO19.11025 SUP45; translation release factor eRF1

K12812 CaO19.5647


K12812 CaO19.13092


K14411 CaO19.5989

HRP1; likely RNA binding protein containing two RRMs; similar to S. cerevisiae HRP1 (YOL123W) component of cleavage and polyadenylation factor CF I

K14411 CaO19.13410

HRP1; likely RNA binding protein containing two RRMs; similar to S. cerevisiae HRP1 (YOL123W) component of cleavage and polyadenylation factor CF I

03013 RNA Transport K14306 CaO19.8519

NSP1; weak similarity to nuclear pore protein wih XFXFG motifs

K03260 CaO19.3599

TIF46; similar to S. cerevisiae TIF4631 (YGR162W) and TIF4632 (YGL049C) mRNA cap binding complex eIf4F subunit, eIF-4G

K14319 CaO19.9218

RNA1; similar to GAP for Gsp1p (Ran), nuclear export

K14319 CaO19.1649

RNA1; similar to GAP for Gsp1p (Ran), nuclear export

K03257 CaO19.10834

TIF1; similar to S. cerevisiae TIF1 (YKR059W) and TIF2 (YJL138C) translation initiation factor eIF4A subunit

K03257 CaO19.3324

TIF1; similar to S. cerevisiae TIF1 (YKR059W) and TIF2 (YJL138C) translation initiation factor eIF4A subunit

K12812 CaO19.5647


K12812 CaO19.13092


K03259 CaO19.7626 CDC33; mRNA

cap-binding protein eIF4E, translation initiation; similar to S. cerevisiae CDC33 (YOL139C)

K14290 CaO19.7483

CRM1; Chromosome region maintenance protein

K03754 CaO19.825

GCD7; similar to S. cerevisiae GCD7 (YLR291C) beta subunit of eIF-2B, the guanine nucleotide exchange factor for translation initiation factor eIF2

K07936 CaO19.5493


K07936 CaO19.12948


K03258 CaO19.10927

TIF3; similar to S. cerevisiae TIF3 (YPR163C) translation initiation factor eIF-4B

K03258 CaO19.3423

TIF3; similar to S. cerevisiae TIF3 (YPR163C) translation initiation factor eIF-4B

K03262 CaO19.11737

TIF5; similar to S. cerevisiae TIF5 (YPR041W) translation initiation factor eIF5

K03262 CaO19.4261

TIF5; similar to S. cerevisiae TIF5 (YPR041W) translation initiation factor eIF5

K03252 CaO19.12105

NIP1; subunit of translation initiation complex eIF3

K14298 CaO19.1095 GLE2; WD40 repeat protein

similar to S. cerevisiae GLE2 (YER107C) nuclear pore protein required for poly(A)+ RNA export

Membrane Transport

02010 ABC Transporters K05658 CaO19.7440

HST6; potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export

Transport & Catabolism 04145 Phagosome K02147 CaO19.13955

VMA2; vacuolar ATPase V1 domain subunit B

K07375 CaO19.6034

TUB2; C terminus of beta-tubulin; two 5' exons upstream of 2 introns; similar to S. cerevisiae TUB2 (YFL037W)

K07375 CaO19.13455

TUB2; C terminus of beta-tubulin; two 5' exons upstream of 2 introns; similar to S. cerevisiae TUB2 (YFL037W)

K02149 CaO19.10413

VMA8; similar to S. cerevisiae VMA8 (YEL051W) vacuolar ATPase V1 domain subunit D

K10956 CaO19.6176



K07374 CaO19.7308

TUB1; cytoskeletal structural protein; 5' exon upstream of intron; similar to S. cerevisiae TUB1 (YML085C)

K02145 CaO19.9249 TFP1; likely vacuolar ATPase V1 complex subunit A similar to S. cerevisiae TFP1 (YDL185W);

homing endonuclease intein segment is absent; splicing of upstream intron creates start codon; allelic CaP19.1680 is truncated due to frameshift

K10956 CaO19.6176



04146 Peroxisome K04564 CaO19.10848

SOD2; likely mitochondrial manganese-containing superoxide dismutase similar to S. cerevisiae SOD2 (YHR008C)

K04564 CaO19.11420

RSM26; similar to S. cerevisiae RSM26 (YJR101W) mitochondrial ribosome small subunit protein

K04564 CaO19.1662

MRP1; similar to S. cerevisiae MRP1 (YDR347W) mitochondrial ribosome small subunit protein

K01897 CaO19.7156


K01897 CaO19.7379


K01897 CaO19.7592 FAA4; similar to S. cerevisiae FAA4 (YMR246W) long-

chain fatty acid--CoA synthetase

K01897 CaO19.272


K00232 CaO19.13146


K00232 CaO19.1652


K13237 CaO19.11168

similar to peroxisomal 2,4-dienoyl-CoA reductase

K13237 CaO19.11633

SPS199; SPS19-like orf, peroxisomal 2,4-dienoyl-CoA reductase

K13343 CaO19.1805

PEX14; similar to P. pastoris PEX14 (AF200421) and to S. cerevisiae PEX14 (YGL153W) peroxisomal peripheral membrane protein (peroxin)

K15118 CaO19.1804

potential mitochondrial carrier family protein similar to S. cerevisiae YDL119C inner mitochondrial membrane protein

K13237 CaO19.11633

SPS199; SPS19-like orf, peroxisomal 2,4-dienoyl-CoA reductase

K13343 CaO19.9371 PEX14; similar to P.

pastoris PEX14 (AF200421) and to S. cerevisiae PEX14 (YGL153W) peroxisomal peripheral membrane protein (peroxin)

K13237 CaO19.11168

similar to peroxisomal 2,4-dienoyl-CoA reductase

K11187 CaO19.424


04140 Regulation of Autophagy K08332 CaO19.745

VAC8; vacuolar inheritance and protein targeting

K08337 CaO19.707

ATG7; similar to S. cerevisiae ATG7 (YHR171W) protein-conjugating enzyme of the Apg12p-Apg5p conjugation pathway of autophagy

04144 Endocytosis K03283 CaO19.8667


K03283 CaO19.1065


K03283 CaO19.13724 SSB1; HSP70



K04646 CaO19.10990

CHC1; presumed vesical coat protein (clathrin heavy chain)

K04646 CaO19.3496 CHC1; presumed vesical coat protein

(clathrin heavy chain)

K12492 CaO19.11167

GCS1; potential ADP ribosylation factor GTPase activating protein (ARF GAP) similar to S. cerevisiae GCS1 (YDL226C) ARF GAP with a role in membrane traffic

K12196 CaO19.11814

VPS4; likely AAA ATPase similar to S. cerevisiae VPS4 (YPR173C) AAA ATPase involved in vacuolar sorting

K12196 CaO19.4339

VPS4; likely AAA ATPase similar to S. cerevisiae VPS4 (YPR173C) AAA ATPase involved in vacuolar sorting

K01115 CaO19.1161


K12195 CaO19.897 similar to Snf7p

Documents

mbio.asm.org · Web viewCPA2; likely carbamoyl-phosphate synthase large subunit similar to S. cerevisiae CPA2 (YJR109C) invovled in arginine biosynthesis K03017 CaO19.2276 Replication