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MDM2 Discovery: A gene amplified in sarcoma
Mdm2 Gene Amplification in Gastric Cancer Correlation with Expression of Mdm2 Protein and p53 Alterations, Thomas Günther, et, al
In Normal cell, MDM2 is a negative regulator
1) Binds to p53 transactivation domain
2) Induces nuclear export
3) Ubiquitinate for degradation
MDM2 and Cancer
7 % Mdm2 amplification in 3000 tumors from 28 tumor types
Osteosarcomas and soft tissue sarcomas have highest rate 20%, 16%