160 Metropolitan Research Laboratory of Public Health until 1978, and later joined the National Institute for Environmental Studies. His cur- rent research activity is determination and evaluation of inorganic and organic trace contaminants in the environment. He is a member of IUPAC, Division of Analytical Chemistry. Keiichiro Fuwa, D. Sci., is an emeritus professor of the University of Tokyo. He graduated from the University of Tokyo in 1948, and was granted the D. Sci. degree at that institution in 1954. He was awarded a Fulbright Fellowship, worked in Arkansas University and in 1956 joined the Biophysics Research Laboratory of Harvard Medical School, Boston. In 1968 he returned to Japan as a professor in the Department of Agricultural Chemistry of the University of Tokyo, and in 1975 moved to the Department of Chemistry. Along with his university work he was also division chief of the Chemistry and Physics Division with the Environment Agency, and Deputy Director General and later Di- rector General of the National Institute for Environmental Studies. His research interests cover a wide area and include analytical chemistry, bioinorganie chemistry, biogeochemistry and environmental sciences. Dr. Fuwa was awarded the Japan Analytical Chemical Society Prize in 1976, and the Miyake Prize in 1983. Mechanismsfor Gene Conversion and Homologous Recombination: The Double- strand Break Repair Model and the SuccessiveHalf Crossing-over Model Ichizo KOBAYASHI, Ph. D., is an associate professor in the Department of Molecular Biology of the Institute of Medical Science, the University of Tokyo. He graduated from the University of Tokyo in 1974 and received his Ph.D. from that institution in 1979. He has also served in the Institute of Molecular Biology of the University of Oregon in U.S.A., Medical School of the University of Tokyo, and the National Children's Medical Research Center in Tokyo. His interest is in anal- ysis of molecular mechanisms of DNA homologous recombination and its application to gene targeting and gene therapy. Compliance of Genetic Code with Base-composition Deflecting Pressure Akiyoshi WADA, D. Sc., is an emeritus professor of the University of Tokyo, Director of the Sagami Chemical Research Center, and a member of the Science Council of Japan. From 1970 to 1990 he was professor of biophysics in the Department of Physics, Faculty of Science of the University of Tokyo. He graduated from the Chemistry Depart- ment of the same faculty in 1952 and started his work on biological

Mechanisms for gene conversion and homologous recombination: The double-strand break repair model and the successive half crossing-over model

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Metropolitan Research Laboratory of Public Health until 1978, and later joined the National Institute for Environmental Studies. His cur- rent research activity is determination and evaluation of inorganic and organic trace contaminants in the environment. He is a member of IUPAC, Division of Analytical Chemistry.

Keiichiro Fuwa, D. Sci., is an emeritus professor of the University of Tokyo. He graduated from the University of Tokyo in 1948, and was granted the D. Sci. degree at that institution in 1954. He was awarded a Fulbright Fellowship, worked in Arkansas University and in 1956 joined the Biophysics Research Laboratory of Harvard Medical School, Boston. In 1968 he returned to Japan as a professor in the Department of Agricultural Chemistry of the University of Tokyo, and in 1975 moved to the Department of Chemistry. Along with his university work he was also division chief of the Chemistry and Physics Division with the Environment Agency, and Deputy Director General and later Di- rector General of the National Institute for Environmental Studies. His research interests cover a wide area and include analytical chemistry, bioinorganie chemistry, biogeochemistry and environmental sciences. Dr. Fuwa was awarded the Japan Analytical Chemical Society Prize in 1976, and the Miyake Prize in 1983.

Mechanisms for Gene Conversion and Homologous Recombination: The Double- strand Break Repair Model and the Successive Half Crossing-over Model Ichizo KOBAYASHI, Ph. D., is an associate professor in the Department of Molecular Biology of the Institute of Medical Science, the University of Tokyo. He graduated from the University of Tokyo in 1974 and received his Ph.D. from that institution in 1979. He has also served in the Institute of Molecular Biology of the University of Oregon in U.S.A., Medical School of the University of Tokyo, and the National Children's Medical Research Center in Tokyo. His interest is in anal- ysis of molecular mechanisms of DNA homologous recombination and its application to gene targeting and gene therapy.

Compliance of Genetic Code with Base-composition Deflecting Pressure Akiyoshi WADA, D. Sc., is an emeritus professor of the University of Tokyo, Director of the Sagami Chemical Research Center, and a member of the Science Council of Japan. From 1970 to 1990 he was professor of biophysics in the Department of Physics, Faculty of Science of the University of Tokyo. He graduated from the Chemistry Depart- ment of the same faculty in 1952 and started his work on biological