Figure S1. Percentage of ≥20x coverage per gene for each technological WES condition.

The boxplots show the percentage of base pairs covered by at least 20 reads per gene (DGD20062014, 120 genes) and technological WES condition. Outliers are depicted as dots, representing individual samples. A. Coverage of samples (n=30) enriched with the Agilent 50Mb kit and sequenced on the 5000xl SOLiD system. B. Coverage of samples (n=14) enriched with the Agilent V4 kit and sequenced on the 5000xl SOLiD system. C. Coverage of samples (n=156) enriched with the Agilent V4 kit and sequenced on the HiSeq2000TM system.

Figure S2. Diagnostic yield of WES targeting a panel of HI-related genes, based on age of onset of HI. One individual with late-onset HI was ommited from this analysis, because the exact age of onset was unknown.