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09/15 PCS DF 023 V1 EN

Member of Croda International Plc

Development formulation

Cream “Perfect Youth”with MEDIATONE™(*) & DERMAXYL™(*) & IDEALIFT™(*) & MATRIXYL™ 3000 (*)

SED1407155 A

(*) Mediatone™: Patent pending / Dermaxyl™: Patent WO 2004/101609 / Idealift™ PH: Patent WO 2010/136965 /Matrixyl™ 3000: Patent WO 2005/048968 

% by wtPart AWater deionisedPotassium Sorbate

--

Qsp 100qs

Part BGlycerinXanthan GumHydroxyethyl CellulosePhenoxethanol 

----

5.000.150.15

qs

Part CCrodafos CES-PA-(RB) [Cetearyl Alcohol & DicetylPhosphate & Ceteth-10 Phosphate]Crodamol GTCC-LQ-(MV) [Caprylic/Capric Triglyceride]Pripure 3759-LQ-(GB) [Squalane]Crodamol GTEH-LQ-(MV) [Triethylhexanoin]

Mediatone™ [Octadecenedioic Acid]

Croda

CrodaCrodaCroda

Sederma

5.00

4.005.004.00

1.00

Part DDermaxyl™ [C12-15 Alkyl Benzoate (and) Tribehenin andCeramide 2 (and) PEG 10 Rapeseed Sterol (and) PalmitoylHexapeptide-12] 

Sederma 3.00

Part EIdealift™ [Butylene Glycol (and) Water (and) SorbitanLaurate (and) Hydroxyethylcellulose (and) AcetylDipeptide-1 Cetyl Ester]

Sederma 4.00

Part FWater deionisedSodium hydroxide 30%

--

3.000.30

Part GMatrixyl® 3000 [Glycerin (and) Water (and) ButyleneGlycol (and) Carbomer (and) Polysorbate 20 (and)Palmitoyl Tripeptide-1 (and) Palmitoyl Tetrapeptide-7] 

Sederma 4.00

Part HFragrance (Volupté) Expressions Parfumées 0.10

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09/15 PCS DF 023 V1 EN

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Member of Croda International Plc

Development formulation

Cream with NEW DOIC(*) & DERMAXYL™(*) & IDEALIFT™(*) & MATRIXYL™ 3000 (*)

SED1407155 A

(*) Mediatone™: Patent pending / Dermaxyl™: Patent WO 2004/101609 / Idealift™ PH: Patent WO 2010/136965 /Matrixyl™ 3000: Patent WO 2005/048968 

Method

Weigh Part A with helix stirring (s=400 rpm).

Weigh and homogenize Part B.

 Add Part B to Part A with helix stirring (s=800 rpm). Allow to swell for 30 minutes.

Heat Part A+B to 75°C in bain-marie.

Weigh and heat Part C to 75°C in bain-marie. Mix well.

 Add Part D in Part C. Homogenize well.

 Add Part E into Part A+B with rotor Stator stirring (s=1000 rpm).

Pour Part C+D into Part A+B+E with Stator stirring (s=36000 rpm). Homogenize well.

 Add Part F. Homogenize well.

 Add Part G at around 55°C, homogenize.

Then add Part H below 35°C, homogenize well.

pH : 5.80 +/-0.10

This formulation has been subject to limited stability tests and has been shown to perform well. However formulators adopting thisapproach should ensure to their own satisfaction long term stability and functionality. It is good practice to conduct safety tests on allfinal formulations prior to marketing. Suggested uses should not be taken as an inducement to infringe any existing patents.

Non-guarantee: The information in this publication is given in good faith by Sederma by way of general guidance and for reference

purposes only. The information should not be construed as granting a license to practice any methods or compositions of matter covered

by patents. Sederma assumes no liability in relation to the information and gives no warranty regarding the suitability of the product

and/or ingredients described for a particular use. The use made of the product and/or ingredients described by the recipient and any

claims or representations made by the recipient in respect of such product and/or ingredients are the responsibility of the recipient. The

recipient is solely responsible for ensuring that products marketed to consumers comply with all relevant laws and regulations.

Sederma SAS - 29, rue du Chemin Vert BP 33 - 78612 Le Perray-en-Yvelines Cedex - FranceTel ++33 1 34 84 10 10 Fax ++33 1 34 84 11 30