Medical and Health Science Center

Medical and Health Science Center

Centre for Agricultural Sciences

and Engineering

Centre of Arts, Humanities and

Sciences

• Number of students: 29 121• Academic staff (full time): 1 413• Non-academic staff (full time): 5 312• Annual budget (2007): ~68,6 billion HUF (275 million €)

• Science and Technology

• Humanities• Informatics • Economics • Law• Music • Education

• Medicine• Dentistry • Pharmacy• Public Health• Health Sciences

• Agriculture• Engineering • Rural Development

15 faculties in three centers

• 450 years; the oldest institution of higher education of continuous history in Hungary

University of Debrecen

http://www.detek.unideb.hu/

Molecular Medicine Molecular Cell and Immune Biology Clinical Medicine Clinical Medicine Health Sciences Dentistry Pharmacology and Pharmaceutical

Sciences Mathematics and computing Informatics Physics Chemistry Earth Sciences Biology and Environmental Sciences

Molecular Medicine Molecular Cell and Immune Biology Clinical Medicine Clinical Medicine Health Sciences Dentistry Pharmacology and Pharmaceutical

Sciences Mathematics and computing Informatics Physics Chemistry Earth Sciences Biology and Environmental Sciences

• History and Ethnology• Literature• Linguistics• Humanities (Philosophy, Psychology

and Education)• Law• Economics• Management and Business

Administration• Crop Production, Horticulture and

Food Sciences• Crop Production, Horticulture and

Regional Sciences• Animal Husbandry

Graduate and PhD schools

Based on its research activity UD ranks among the top three universities in Hungary (Ministry of Education);

70% of the academic staff hold PhD degree;

26 members of the Hungarian Academy of Sciences(10 new ones since the year 2000);

11 research groups sponsored by special grant of the Hungarian Academy of Sciences;

23 Ph.D. schools (highest number in Hungary);

Close to 800 PhD students; 150-200 new PhD degrees issued per

annum; R&D income ~4,5 billion HUF/year

(~18 million €).

Based on its research activity UD ranks among the top three universities in Hungary (Ministry of Education);

70% of the academic staff hold PhD degree;

26 members of the Hungarian Academy of Sciences(10 new ones since the year 2000);

11 research groups sponsored by special grant of the Hungarian Academy of Sciences;

23 Ph.D. schools (highest number in Hungary);

Close to 800 PhD students; 150-200 new PhD degrees issued per

annum; R&D income ~4,5 billion HUF/year

(~18 million €).

University of Debrecen: The research university

Research Centre for Molecular Medicine


University of Debrecen, Medical and Health Science Center

University of Debrecen, Medical and Health Science Center

RCMM - introduction 1.RCMM - introduction 1.




Centre of Excellence of the European Union (2002)




Centre of Excellence of the European Union (2002)

RCMM - introduction 2.RCMM - introduction 2.

Research institute Clinically oriented and basic cutting edge

research Collaborating research laboratories Core facilities International partner institutions

Research institute Clinically oriented and basic cutting edge

research Collaborating research laboratories Core facilities International partner institutions

RCMM - Basic Research 1.RCMM - Basic Research 1.

Molecular Mechanism of Apoptosis Apoptosis Signaling Nuclear Hormone Receptor Retroviral Biochemistry

Dendritic Cell Research

Molecular Mechanism of Apoptosis Apoptosis Signaling Nuclear Hormone Receptor Retroviral Biochemistry

Dendritic Cell Research


Cell Biophysics Lymphocyte Electrophysiology Receptor Tyrosine Kinases Cell Biology Membrane Dynamics

Cell Biophysics Lymphocyte Electrophysiology Receptor Tyrosine Kinases Cell Biology Membrane Dynamics

RCMM - Basic research 3.RCMM - Basic research 3.

Signal Transfer Oxidative Stress and ADP-ribosylation Protein Phosphatases in Cellular Signaling Protein Dephosphorylation

Signal Transfer Oxidative Stress and ADP-ribosylation Protein Phosphatases in Cellular Signaling Protein Dephosphorylation


Cellular and Molecular Physiology Calcium Homeostasis and

Transmembrane Signaling K+ Channels in Excitable and Non-

excitable Structures

Cellular and Molecular Physiology Calcium Homeostasis and

Transmembrane Signaling K+ Channels in Excitable and Non-

excitable Structures

RCMM - Clinical ResearchRCMM - Clinical Research

Haemostasis Thrombosis and Vascular Biology Research

Vascular Biology Research Earpathology Genetics of Corneal and Retinal

Dystrophies and Degenerations Cardiology, Clinical Physiology

Haemostasis Thrombosis and Vascular Biology Research

Vascular Biology Research Earpathology Genetics of Corneal and Retinal

Dystrophies and Degenerations Cardiology, Clinical Physiology

RCMM - Core FacilitiesRCMM - Core Facilities

Debrecen Clinical Genomics Centre High-throughput Screening (HTS) Facility Cell Analysis Core Facility Lipidomics Core Facility Laboratory Animal Core Facility Biomolecular Interaction Laboratory Proteomics Core Facility

Debrecen Clinical Genomics Centre High-throughput Screening (HTS) Facility Cell Analysis Core Facility Lipidomics Core Facility Laboratory Animal Core Facility Biomolecular Interaction Laboratory Proteomics Core Facility

Debrecen Award for Molecular Medicine

Debrecen Award for Molecular Medicine

International annual price of 10 000 EUR

Aim: encouraging, recognizing and promoting extraordinary research results

Winner in 2008: Bruce M. Spiegelman

International annual price of 10 000 EUR

Aim: encouraging, recognizing and promoting extraordinary research results

Winner in 2008: Bruce M. Spiegelman

http://rcmm.dote.huhttp://rcmm.dote.hu

Please visit our web site.Please visit our web site.

MOLMEDREX projectMOLMEDREX project

Coordination and Support ActionFP7-REGPOT-2008-1/229920

Coordination and Support ActionFP7-REGPOT-2008-1/229920

http://www.fehrl.org/upload/fckeditor/image/FP7.jpg

RCMMRCMM

Research Centre for Molecular Medicine Basic and cutting edge biomedical

research Research Groups + Core Facilities Centre of Excellence

Research Centre for Molecular Medicine Basic and cutting edge biomedical

research Research Groups + Core Facilities Centre of Excellence

MOLMEDREX - aimsMOLMEDREX - aims

Human potential Research equipment Mobility of researchers Dissemination of results

Human potential Research equipment Mobility of researchers Dissemination of results

Selected Research FieldsSelected Research Fields

-Genomics/Gene expression- Personalized medicine

-Advanced Imaging

-High throughput screening in an academic setting

-Genomics/Gene expression- Personalized medicine

-Advanced Imaging

-High throughput screening in an academic setting

MOLMEDREX - Work PackagesMOLMEDREX - Work Packages

• WP1 Development of the research potential in strategic areas by twinning and partnerships

• WP2 Increasing human potential of RCMM

• WP3 Upgrading infrastructure

• WP4 Establishing RCMM as a regional knowledge centre

• WP5 Dissemination

• WP6 Project management

• WP1 Development of the research potential in strategic areas by twinning and partnerships

• WP2 Increasing human potential of RCMM

• WP3 Upgrading infrastructure

• WP4 Establishing RCMM as a regional knowledge centre

• WP5 Dissemination

• WP6 Project management

MOLMEDREX - WP1MOLMEDREX - WP1

Twinning & Partnership Twinning Partners: DKFZ, EMBL Strategic Partners: 14 leading universities Aim: expanding RTD capacity, gaining further expertise

and new technologies in genomics, imaging and HTS Collaborations: secondments, lab meetings, visits,

lectures seminars

Twinning & Partnership Twinning Partners: DKFZ, EMBL Strategic Partners: 14 leading universities Aim: expanding RTD capacity, gaining further expertise

and new technologies in genomics, imaging and HTS Collaborations: secondments, lab meetings, visits,

lectures seminars

MOLMEDREX- WP2MOLMEDREX- WP2

Increasing human potential of RCMM Aim: reinforcing S & T competitiveness,

upgrading RTD capability in new, highly competent research fields (personalized medicine, stem cell research, molecular imaging etc.)

4 senior and 4 junior researcher positions are offered in different fields

Increasing human potential of RCMM Aim: reinforcing S & T competitiveness,

upgrading RTD capability in new, highly competent research fields (personalized medicine, stem cell research, molecular imaging etc.)

4 senior and 4 junior researcher positions are offered in different fields


Upgrading infrastructure Aims: broadening the scope of methods,

improving efficiency Equipment purchased is unique in the region

and nationwide (Microarray platform, Semi-automatized Patch Clamp robot, Andor camera, Microplate dispenser, centrifuge, UV irradiator, TIRF PALM Microscope purchase in progress)

Upgrading infrastructure Aims: broadening the scope of methods,

improving efficiency Equipment purchased is unique in the region

and nationwide (Microarray platform, Semi-automatized Patch Clamp robot, Andor camera, Microplate dispenser, centrifuge, UV irradiator, TIRF PALM Microscope purchase in progress)


Establishing RCMM as a regional knowledge centre in the field of biomedical research

Training courses, conferences, workshops will be organized

E.g. GeneSpring course, Practical Course on Techniques in Free Radical Biology (http://febs.unideb.hu)

Co-funding by EMBO or FEBS

Establishing RCMM as a regional knowledge centre in the field of biomedical research

Training courses, conferences, workshops will be organized

E.g. GeneSpring course, Practical Course on Techniques in Free Radical Biology (http://febs.unideb.hu)

Co-funding by EMBO or FEBS

http://febs.unideb.hu/

http://febs.unideb.hu/


Dissemination of results Aims: dissemination, marketing, promotion of results E-platform, newsletters, brochures, publications, presentation at

international conferences, Alumni program, Annual report etc. Target groups: regional, national, EU, global research facilities in

academia and industry (Biotech, Pharma), policy-makers, politicians, legislative bodies, selected patient groups, multiple sectors of the lay public

Dissemination of results Aims: dissemination, marketing, promotion of results E-platform, newsletters, brochures, publications, presentation at

international conferences, Alumni program, Annual report etc. Target groups: regional, national, EU, global research facilities in

academia and industry (Biotech, Pharma), policy-makers, politicians, legislative bodies, selected patient groups, multiple sectors of the lay public


Aims: administration, coordination and motivation of all the activities in the project

Advisory group (senior scientists of UD, local biotech, local government, national R&D agency)

Aims: administration, coordination and motivation of all the activities in the project

Advisory group (senior scientists of UD, local biotech, local government, national R&D agency)

Expected results of MOLMEDREX projectExpected results of

MOLMEDREX project

As a result RCMM will become a more potent and prepared research centre in the Eastern part of Hungary with an improved

human and infrastructural capacity to tackle key issues in molecular medicine for the benefit of the population of the region.

As a result RCMM will become a more potent and prepared research centre in the Eastern part of Hungary with an improved

human and infrastructural capacity to tackle key issues in molecular medicine for the benefit of the population of the region.

http://molmedrex.dote.huhttp://molmedrex.dote.hu

Please visit our web site!Please visit our web site!

Thank you for your attention!

Thank you for your attention!

http://www.fehrl.org/upload/fckeditor/image/FP7.jpg

Debrecen Clinical Genomics Center

http://genomics.dote.hu

Debrecen Clinical Genomics Center

http://genomics.dote.hu

ServicesServices

Study design, consulting Patient recruitment Biobanking Integrated database Functional analysis: Functional genomic analysis services and

epigenomic analysis services Data analysis / mining

Study design, consulting Patient recruitment Biobanking Integrated database Functional analysis: Functional genomic analysis services and

epigenomic analysis services Data analysis / mining

InfrastructureInfrastructure

Affymetrix GeneChip 3000 7G System, 2 pc ABI 7900 Real-time quantitative PCR instruments, ABI 310 Avant DNA sequencer, 2 pc Light Cycler 480 (Roche) MMI UV cut laser microdissector, Tecan Genesis RSP150 Tecan Miniprep 75 MagnaPure LC FaCScalibur Agilent Bioanalyzer 2100 2 pc NanoDrop 1000

Affymetrix GeneChip 3000 7G System, 2 pc ABI 7900 Real-time quantitative PCR instruments, ABI 310 Avant DNA sequencer, 2 pc Light Cycler 480 (Roche) MMI UV cut laser microdissector, Tecan Genesis RSP150 Tecan Miniprep 75 MagnaPure LC FaCScalibur Agilent Bioanalyzer 2100 2 pc NanoDrop 1000

MethodsMethods

Microarray technology Real-time quantitative PCR including Minimal residual

disease (MRD) analysis, miRNA detection, Genotyping qPCR Assay (SNP detection), TaqMan Low Density Array (Microfluidics Card)

Sanger DNA sequencing; Nucleic acid isolation; Molecular cloning Chromatin immunoprecipitation (ChIP) Methylated DNA Immunoprecipitation (MeDIP)

Microarray technology Real-time quantitative PCR including Minimal residual

disease (MRD) analysis, miRNA detection, Genotyping qPCR Assay (SNP detection), TaqMan Low Density Array (Microfluidics Card)

Sanger DNA sequencing; Nucleic acid isolation; Molecular cloning Chromatin immunoprecipitation (ChIP) Methylated DNA Immunoprecipitation (MeDIP)

ReferencesReferencesDebrecen Clinical Genomics Center 2001

– 20072005-2007 Biosystems International SAS, 2006-2007 Richter Gedeon Nyrt.,2006-2007 AstraZeneca2001-2007 Pfizer Global Research

UD-GenoMed Ltd. 2008 –

Debrecen Clinical Genomics Center 2001 – 20072005-2007 Biosystems International SAS, 2006-2007 Richter Gedeon Nyrt.,2006-2007 AstraZeneca2001-2007 Pfizer Global Research

UD-GenoMed Ltd. 2008 –

Documents

Medical and Health Science Center