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MediSapiens Ltd Because data is not knowledge

Sami Kilpinen, Ph.D Co-founder, CEO MediSapiens Ltd

19th of March 2015

Bio-IT solutions for improving cancer patient care

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MediSapiens – Brief overview Company Overview: •  Finland based Bio-IT company •  Founded 2009 •  Employee count: 18 •  Offices: Helsinki, Boston

Established solution provider for: •  Biopharmaceutical companies with active drug R&D pipelines •  Personalized healthcare

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Key IP: •  Multiple algorithm & technology patents pending •  Significant proprietary expertise •  R&D and product development since 2004 with more than 50 person-years of development

Key achievements: •  Roughly doubling turnover each year •  Major solution provider of genomics and research data analytics for international pharmaceutical companies •  B2B partner for consumer genomic solutions •  Product development for clinical cancer diagnostics market

MediSapiens is en route to be the world leader in enabling scientific Bio-IT solutions for biomedical big data in research, healthcare and personal medicine.

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World is producing exponentially growing amounts of clinical, genomic and health related data. Products and services are needed so that expensive investments can be turned into knowledge that justifies the expenses and brings well-being for society. Thus there is a growing need - ethical, medical and economical - to provide products and services based on this data. However, it requires rather deep know-how and investment in both Bio- and IT-fields. Translating biomedical science into products and services with cutting-edge Bio-IT is exactly the field where MediSapiens has been operating since 2009.

Data is not knowledge

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MediSapiens – Services and Products MediSapiens custom services

•  Bioinformatic science together with cutting edge IT and pharmaceutical industry tested security

•  Scalable Bio-IT platform to leverage data driven innovations into products in genomic, clinical and health applications

MediSapiens products

MediSapiens offers a wide selection of software and products for biological research.

“BIO-IT SOLUTIONS FOR MOST AREAS OF GENOMICS AS WELL AS OTHER BIOLOGICAL SCIENCES”

SEQUENCE

METHYLATION CNV

EXPRESSION

CLINICAL AND

PHENOTYPIC COVARIATES

INNOVATE! IMPORT STORE MANAGE EXPLORE SHARE IMPORT YOUR GENOMICS DATA EASILY TO THE EXPLORER PLATFORM IMPORT ALSO ALL THE CLINICAL AND PHENOTYPIC INFORMATION RELEVANT TO YOUR SAMPLES

STORE ALL YOUR IMPORTANT GENOMICS INFORMATION IN ONE PLACE THAT IS ALWAYS ACCESSIBLE

MANAGE YOUR DATASETS FROM ALL EXPERIMENTS IN ONE PLACE FORGET THE DATA HANDLING NIIGHTMARE OF MULTIPLE FILES AND FOLDERS

SHARE YOUR DATASETS AND ANALYSIS WITH YOUR COLLEAGUES AND COLLABORATORS EASILY WITHIN THE EXPLORER PLATFORM

EXPLORE YOUR GENOMICS, CLINICAL AND PHENOTOPIC COVARIATES INDIVIDUALLY OR TOGETHER USING THE POWERFUL ANALYSIS TOOLS AND VISUALIZATIONS IN THE EXPLORER PLATFORM

EXPLORE, MINE AND FILTER YOUR DATA FREELY WITHIN THE EXPLORER PLATFORM! CREATE NEW IDEAS, HYPOTHESIS AND INNOVATIONS WITH DATA EXPLORATION!

EXPLORER ENABLES SERENDIPITY THROUGH EFFORTLESS DATA INTEGRATION AND EXPLORATION!

USER DATA Researcher, clinician…

DATA DISTRIBUTION Biobanks, public projects,

sequencing facilities… 3rd PARTY ACCESS Patients, clinics, new

software modules

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Strategic partnerships with the pharmaceutical industry •  Biond Explorer enables researchers to

tap into huge genomic and clinical datamasses conveniently from their web browsers.

Solutions for Drug Developers

•  Research Integrator, software for handling model cell line data and cell line batch logistics. •  Integrated Genomics Platform for handling all public and proprietary genomics and clinical data

throughout the organization and seamlessly across research fields (cardiology, oncology etc…)

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MediSapiens is developing a consumer level dog genomics solution together with Genoscoper Ltd. •  MyDogDNA.com – product of Genoscoper •  Bio-IT infrastructure, algorithms and customer portal developed and maintained

by MediSapiens •  Brings “personal” genomic scale diagnostics of pet animals for recreational,

breeding and veterinary use

Solutions for Genome Level Diagnostics 6

MyDogDNA Pass™www.MyDogDNA.com

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MediSapiens and International Cancer Advocacy Network (ICAN) published on the 26th of January 2015 in the Personalized Medicine World Congress a joint effort to bring a product called Remission Coach globally available in 2015.

Solutions for Personal Cancer Care

Remission Coach will allow: •  Tens of thousands of cancer patients

around the world to log in their genomic and clinical information as well as their daily well-being

•  Find a suitable clinical trial for the patient from tens of thousands of trials

•  Collaboration program with major pharmaceutical companies to help them to recruit clinical cohorts via Remission Coach

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Both biobanks and clinical laboratories have an increasing need for IT solutions for handling genomics data together with clinical data. MediSapiens has a ready industry tested software solution to store, manage and explore terabyte level datasets with genomic and clinical data.

Solutions for Biobanks & Clinical Laboratories

Genomic data

Clinical data

Health data

Clinician

Laboratory personnel

Biobank customers and collaborators

We are actively calling for Finnish collaborators and partners!

MediSapiens is in active collaboration with OncoDNA, one of world’s leading oncology diagnostics providers to provide next-generation cancer patient genome interpretation tools.

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1.  In order to improve cancer care we need more and more solutions, products and services.

2.  MediSapiens has been working since 2009 on building dedicated Bio-IT solutions. 3.  MediSapiens can bring in bioinformatic science and software development resources

to digitize almost any aspect of future cancer care – from drug R&D to daily life of a patient.

4.  We can say from experience that there is an increasing international interest towards Finnish know-how of genomics, health information and records.

5.  There are great possibilities to create new biomedical and bio-it export business in Finland – ”just what doctors ordered for the country” – just that opportunity is now and not in a few years and therefore might require immediate and visionary steps.

Take home message

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MediSapiens Ltd. Erottajankatu 19B 00130 Helsinki Finland

+358 45 8478878 contact@medisapiens.com medisapiens.com

MediSapiens Inc. One Broadway Cambridge, MA 02142 USA