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www.virology-education.com MEETING PROSPECTUS 6 TH INTERNATIONAL WORKSHOP ON BALTIMORE, MD, USA OCTOBER 2015 HIV&AGING www.virology-education.com

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www.virology-education.com

MEETING PROSPECTUS

6TH INTERNATIONAL WORKSHOP ON

BALTIMORE, MD, USA • OCTOBER 2015

HIV&AGING

www.virology-education.com

26th International Workshop on HIV & Aging October 2015, Baltimore,USA

CONTENT

Introduction .......................................................................................... 3

Workshop description ........................................................................... 4

Background .............................................................................................4

Meeting Objectives ..................................................................................4

Learning Objectives ................................................................................4

Format ....................................................................................................4

Unique Meeting Features .......................................................................5

Demographics .........................................................................................5

Geographical distribution .......................................................................5

Organizing Committee .......................................................................... 6

Scientific Committee ............................................................................ 7

Participants’ Feedback 2013 ................................................................. 8

Overall Evaluation ...................................................................................8

Impact of Learning Objectives ................................................................8

Lectures ..................................................................................................9

Metrics 2013 .........................................................................................11

Pre-workshop Communications ...........................................................11

Post-workshop Communications .........................................................11

Most Effective Elements ......................................................................12

Quotes ...................................................................................................12

Summary ..............................................................................................13

36th International Workshop on HIV & Aging October 2015, Baltimore,USA

INTRODUCTION

The annual international Workshop on HIV & Aging was initiated in 2009 as a unique and much needed platform for international scientific exchange on the increasingly recognized problems of HIV and aging. As in previous years, the 2015 - edition will gather a crossdisciplinary team of experts and trainees involved in HIV and aging research, in order to present and discuss the latest developments and strategies for the future, in an interactive and science - focused setting.

The meeting will have a two day program consisting of invited lectures, abstract-driven scientific presentations and poster sessions. The latest developments will be reviewed and evaluated in order to identify important topics for future research, develop better approaches to treatment, and create a strategic agenda for future management problems associated with HIV and aging. This workshop is intended as a small, focused meeting to encourage scientific dialogue among all attendees, including presenters.

This meeting prospectus is designed in order to provide information on the meeting set-up, demographics and metrics and also on the evaluation scores from the participants of the previous editions. We hope this information is of interest. Please contact us if specific information is missing and we will gladly provide you with additional documentation.

We would surely welcome your suggestions for improvement of this workshop in order to best serve the international community treating aging HIV - infected patients.

On behalf of the Organizing Committee,

CHARLES FLEXNER, MD

Johns Hopkins University School of Medicine, USA

SCOTT LETENDRE, MD

University of California, San Diego, USA

Chairs 2015

46th International Workshop on HIV & Aging October 2015, Baltimore,USA

WORKSHOP DESCRIPTION

BACKGROUNDThe annual international Workshop on HIV & Aging was initiated in 2009 as a unique and much needed platform for international scientific exchange on the increasingly recognized problems of HIV and aging. Last year’s edition gathered a cross-disciplinary team of experts and trainees involved in HIV and aging research, in order to present and discuss the latest developments and strategies for the future, in an interactive and science - focused setting.

The 2013 - edition of International Workshop on HIV & Aging was CME - accredited by the University of California, San Diego School of Medicine. As always, the workshop was abstract-driven. To ensure the quality of the presentations, all abstracts were reviewed by the Organising and Scientific Committees.

MEETING OBJECTIVES• To gather crossdisciplinary professionals in an interactive workshop setting

• To provide a platform for presentation and discussion of the latest developments in the field of HIV and aging

• To share cutting-edge information

• To translate knowledge to daily clinical practice

• To stimulate discussion among different disciplines

• To build collaborations

Improved management of older individuals with HIV will require a much deeper understanding of the interface between aging, HIV, associated co-morbid conditions, and concurrent treatment. In addition, research is needed to address the unique psychosocial challenges faced by this growing population.

LEARNING OBJECTIVESAfter participating in this activity, the participants will:

• Identify age-related clinical complications found in the aging HIV-infected patient

• Integrate the latest scientific research into daily clinical care to improve the quality of life of these patients

• Identify the future challenges faced by this expanding population of elderly HIV infected patients

FORMATThe two-day meeting program consists of invited lectures, abstract-driven scientific presentations and poster sessions.

The meeting is abstract-driven. To ensure the quality of accepted abstracts, all submitted abstracts go through a blind, peer-reviewed process conducted by the members of the Organizing and Scientific Committees. The below table shows the abstract submission statistics from the past three years:

2011 2012 2013

Total number accepted abstracts 33 29 30

Oral presentations 17 17 18

Poster presentations 16 12 12

56th International Workshop on HIV & Aging October 2015, Baltimore,USA

UNIQUE MEETING FEATURESThe International Workshop on HIV & Aging remains the only platform in the world for international exchange and dialogue for cross-disciplinary team of experts involved in HIV and aging research. The meeting gathers a steady international community of researchers and healthcare professionals. The compact size of the meeting stimulates interaction, which is considered one of the most effective elements of this program.

TARGET AUDIENCEInternal Medicine specialists working in cardiovascular, renal, endocrine, and metabolic complications of HIV areas, Infectious Disease specialists (virologists, immunologists pharmacologists), geriatricians, neurologists, epidemiologists, geneticists and other clinical researchers.

DEMOGRAPHICS2011 2012 2013

Clinicians 59% 64% 55%

Scientists/ Researchers 7% 5% 7%

Post - graduate students 14% 9% 18%

Regulator/Industry 11% 9% 9%

Other 9% 13% 11%

TOTAL number of participants 119 102 93

Returning participants 39% 36% 45%

New participants 61% 64% 55%

GEOGRAPHICAL DISTRIBUTION LAST MEETING

Canada 12

Denmark 1

France 1

India 1

Israel 1

Italy 1

Spain 1

Switzerland 2

The Netherlands 1

Uganda 2

United Kingdom 1

USA 69

66th International Workshop on HIV & Aging

October 2015, Baltimore,USA

56h International Workshop on HIV & Aging 20- 21 October 2014, Baltimore,USA

ORGANIZING COMMITTEE

CHARLES BOUCHER, MD, PHD

Erasmus Medical Center, Rotterdam, the Netherlands

CHARLES BOUCHER, MD, PHD

Erasmus Medical Center, Rotterdam, the Netherlands

RUSSELL TRACY, PHD

University of Vermont, USA

JACQUELINE CAPEAU, MD, PHD

INSERM, France

CHARLES FLEXNER, MD

Johns Hopkins University School of Medicine, USA

WILLIAM ERSHLER, MD

IASIA, USA

SCOTT LETENDRE, MD

University of California, San Diego, USA

SUSAN RESNICK, PHD

National Institutes of Health / National Institute of Aging, USA

JULES LEVIN, MS

NATAP, USA

JONATHAN SCHAPIRO, MD

Sheba Medical Center, Israel

76th International Workshop on HIV & Aging

October 2015, Baltimore,USA

56h International Workshop on HIV & Aging 20- 21 October 2014, Baltimore,USA

SCIENTIFIC COMMITTEE

Bruce Brew . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .University of New South Wales, Australia

Todd Brown . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .Johns Hopkins University, USA

David Clifford . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .Washington University School of Medicine, USA

Steven Deeks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .University of California, San Francisco, USA

Daniel Duprez . . . . . . . . . . . . . . . . . . . . . . . . . . . . .University of Minnesota, USA

Julian Falutz . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .McGill University, Canada

Steven Grinspoon . . . . . . . . . . . . . . . . . . . . . . . . . . .Massachusetts General Hospital, USA

Alan Landay . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .Developmental Center for AIDS Research, USA

Michael Lederman . . . . . . . . . . . . . . . . . . . . . . . . . .Case Western Reserve University, USA

Jens Lundgren . . . . . . . . . . . . . . . . . . . . . . . . . . . . .Hvidovre University Hospital, Denmark

Avindra Nath . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .National Institute of Neurological Disorders and Stroke/NIH, USA

Eugènia Negredo . . . . . . . . . . . . . . . . . . . . . . . . . . .Universitat Autònoma de Barcelona, Spain

Victor Valcour . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .University of California, San Francisco, USA

86th International Workshop on HIV & Aging October 2015, Baltimore,USA

PARTICIPANTS’ FEEDBACK 2013

OVERAL EVALUATIONThis meeting:

Agree Neutral Disagree

...met my primary objective 97% 3% 0%

...was relevant to my practice / profession 97% 3% 0%

... was presented in an appropriate learning format 97% 3% 0%

...syllabus was clearly written and understandable 90% 7% 3%

...balance of Active vs Passive learning was appropriate 85% 12% 3%

...overal quality was excellent 91% 6% 3%

...tuition for this program was appropriate 84% 16% 0%

...quality of the meeting site was excellent 94% 6% 0%

...assistance at the reqistration desk was excellent 97% 3% 0%

...was free of commercial bias 93% 7% 0%

IMPACT OF LEARNING OBJECTIVESAfter completing this activity, participants will be able to:

High Moderate No impact

• Identify age related clinical complications found in the aging HIV-infected patient

Increased competence 75% 25% 0%

Improved performance 67% 33% 0%

Improved patient outcomes 55% 42% 3%

• Integrate the latest scientific research into daily clinical care to improve the quality of life of these patients

Increased competence 76% 21% 3%

Improved performance 74% 23% 3%

Improved patient outcomes 55% 39% 6%

• Identify the future challenges faced by this expanding population of elderly HIV infected patients

Increased competence 89% 11% 0%

Improved performance 73% 24% 3%

Improved patient outcomes 72% 22% 6%

96th International Workshop on HIV & Aging October 2015, Baltimore,USA

PARTICIPANTS’ FEEDBACK 2013

LECTURES

WEDNESDAY, 30 OCTOBER

Session 1: Genetics of Aging and HIV

Genetics of Aging and HIV

H. Clifford Lane, MD, NIAID, NIH, Bethesda, MD, USA

Excellent/Good Average Fair/Poor

Content 89% 8% 3%

Presentation 94% 6% 0%

HIV Genomics

Paul McLaren, PhD, Lausanne University Hospital, École Polytechnique Fédérale du Lausanne, Switzerland

Excellent/Good Average Fair/Poor

Content 100% 0% 0%

Presentation 100% 0% 0%

Genomics of Aging

Amy Matteini, MD Johns Hopkins University, USA

Excellent/Good Average Fair/Poor

Content 94% 3% 3%

Presentation 94% 3% 3%

Session 2: Hypercoaguability - Aging - HIV infection

Inflammation/aging and hypercoaguability

Bindu Kanapuru, MD, IASIA, USA

Excellent/Good Average Fair/Poor

Content 89% 8% 3%

Presentation 84% 16% 0%

Coagulopathy of Aging and HIV

Jason Baker, MD, MSc,University of Minnesota, Minneapolis, MN, USA

Excellent/Good Average Fair/Poor

Content 97% 3% 0%

Presentation 100% 0% 0%

Session 3: Interplay between Alcohol/Substance abuse & HIV

Opiates and Aging

Gregory Lucas, MD, PhD,Johns Hopkins School of Medicine, Baltimore, MD, USA

Excellent/Good Average Fair/Poor

Content 87% 13% 0%

Presentation 92% 8% 0%

Methamphetamine, HIV, and Aging

Steven Woods, PsyD, University of California, San Diego, CA, USA

Excellent/Good Average Fair/Poor

Content 97% 3% 0%

Presentation 97% 3% 0%

106th International Workshop on HIV & Aging October 2015, Baltimore,USA

THURSDAY 31 OCTOBER

Session 4: Clinical / immunological aspects of aging

Vaccines in immunocomprised patients

Carlos del Rio, MD, Emory University, Atlanta, GA, USA

Excellent/Good Average Fair/Poor

Content 97% 3% 0%

Presentation 95% 5% 0%

Effect of aging on the clinical manifestations of infections

Kevin High, MD, MS, Wake Forest School of Medicine, Winston- Salem, NC, USA

Excellent/Good Average Fair/Poor

Content 97% 3% 0%

Presentation 100% 0% 0%

Session 8: Multi - morbidity in Aging

Aging and comorbidities in the Swiss cohort

Philip Tarr, MD, University of Basel, Basel, Switzerland

Excellent/Good Average Fair/Poor

Content 100% 0% 0%

Presentation 93% 7% 0%

PARTICIPANTS’ FEEDBACK 2013

116th International Workshop on HIV & Aging October 2015, Baltimore,USA

PRE-WORKSHOP COMMUNICATIONSFrequency/ Number

Publicity through electronic newsletter 5 newsletters (outreach: ca. 1700 recipients)

Flyers at other meetings International Workshop on HIV & Women, CROI, ISHEID, International Workshop on HIV Pediatrics

Communications through NATAP (outreach: 50.000-70.000 recipients)

Yes, repeatedly. Jules Levin (founder of NATAP) is a member of the Organizing Committee

Invitations from industry Partly (restricted in the US)

Other Invitations through various research groups

POST-WORKSHOP COMMUNICATIONSFrequency/Number

Workshop materials on the website Presentation of speakers for online reviewing was posted on http://www.infectiousdiseasesonline.com/

Reviews in Antiviral Therapy 600 adresses

Publications at VE Bi-monthly Journal This bi-monthly journal, issued by Virology Education, publishes abstracts and conference reports of international workshops in the field of clinical management of viral diseases.

Media coverage Interviews by IFARA: http://accesshiv.org

Meeting report Meeting report by Mark Mascolini, published in Reviews on Antiviral Therapy and distributed by NATAP

METRICS 2013

126th International Workshop on HIV & Aging October 2015, Baltimore,USA

MOST EFFECTIVE ELEMENTS

QUOTES• An outstanding program again this year!

• The concept of AIDS and aging itself is a new concept. Many people have plenty of doubts about AIDS and aging

• Outstanding speakers

• The oral presentations + invited lectures were quite helpful in broadening my knowledge base on HIV & Aging. The sessions were well moderated

• Interactions among the attendees

• Excellent organization of syllabus - nice balance of basic/clinical

• Private discussions with investigators in the field

• Small size of the meeting makes meeting people quite easy - I’d keep the small size

• Networking with leaders

• Good place for discussion

• Talks by non-HIV experts

• The relatively small size with opportunities for interaction. Question periods very well organized

• Bringing together experts from different disciplines

• Good mix between lectures and topics + research presentations

136th International Workshop on HIV & Aging October 2015, Baltimore,USA

With an aging HIV-infected population - and suggestions that HIV itself may cause conditions normally associated with aging - there is a pressing need for more scientific dialog on this topic. Improved management of older individuals with HIV will require a much deeper understanding of the interface between aging, HIV, associated co-morbid conditions, and concurrent treatment. In addition, research is needed to address the unique psychosocial challenges faced by this growing population. The International Workshop on HIV & Aging remains a unique and much needed platform for international scientific exchange on this important topic. The crossdisciplinary character of the meeting together with its compact size, which stimulates interaction among the participants and discussion, are considered the most effective elements of this program.

The Organizing Committee is pleased with the evaluation results of the 4th International Workshop on HIV & Aging. We therefore look forward to organizing the 5th edition of the workshop and to welcoming old and new participants on 20 - 21 October 2014 and to the continuation of this meeting in 2015.

SUMMARY