MELANOMA BY THE NUMBERS MELANOMA IS A FORM OF SKIN CANCER CHARACTERIZED BY THE UNCONTROLLED GROWTH OF PIGMENT-PRODUCING CELLS (MELANOCYTES) LOCATED IN THE SKIN. THERE ARE FIVE STAGES OF MELANOMA STAGE 0 STAGE 1 & 2 STAGE 3 STAGE 4 MELANOMA IN SITU, OR AN ABNORMALITY ON THE EPIDERMAL REGION OF THE SKIN. EARLY STAGE, LOCALIZED DISEASE. CANCER THAT HAS SPREAD TO THE LYMPH NODES WITHIN THE REGION OF THE CANCER OR TO THE LYMPH VESSELS. CANCER THAT HAS SPREAD TO OTHER MAJOR ORGANS IN THE BODY. Dermis Subcutaneous Tissue Epidermis AN ESTIMATED 287 ,700 NEW MELANOMA CASES ARE DIAGNOSED GLOBALLY EACH YEAR. INCIDENCE OF MELANOMA HAS BEEN INCREASING FOR AT LEAST 5-YEAR SURVIVAL RATES 20 40 60 80 100 92-97% Stage I 53-81% Stage II 40-78% Stage III 15-20% Stage IV Source: American Cancer Society 2017 FAMILY HISTORY AROUND 10% OF ALL PEOPLE WITH MELANOMA HAVE A FAMILY HISTORY OF THE DISEASE. SEVERAL ATYPICAL MOLES MORE THAN 50 COMMON MOLES. UV RAY EXPOSURE MELANOMA IS MORE THAN 20 TIMES MORE COMMON IN WHITES THAN IN AFRICAN AMERICANS. THERE ARE A NUMBER OF FACTORS THAT MAY MEAN YOU ARE AT A HIGHER RISK FOR MELANOMA, INCLUDING: RISK FACTORS IMMUNOTHERAPY CHEMOTHERAPY RADIATION THERAPY TARGETED DRUG THERAPY SURGERY TREATMENT APPROACHES FOR PATIENTS WITH MELANOMA, SURVIVAL RATES VARY GREATLY DEPENDING ON THE STAGE OF DISEASE. FOLLOWING DIAGNOSIS, OPTIONS MAY INCLUDE ONE OR MORE APPROACHES, INCLUDING: MEDIAN AGE 64 70 AT DIAGNOSIS AT DEATH MELANOMA REPRESENTS O1 . 7% OF THE ESTIMATED 18.1 MILLION NEW CANCER CASES WORLDWIDE. 30 YEARS © 2018 Bristol-Myers Squibb Company

MELANOMA BY THE NUMBERS - BMS Study Connect...STAGE 0 STAGE 1 & 2 STAGE 3 STAGE 4 MELANOMA IN SITU, OR AN ABNORMALITY ON THE EPIDERMAL REGION OF THE SKIN. EARLY STAGE, LOCALIZED DISEASE

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MELANOMA BY THE NUMBERSMELANOMA IS A FORM OF SKIN CANCER CHARACTERIZED BY THE UNCONTROLLED GROWTH

OF PIGMENT-PRODUCING CELLS (MELANOCYTES) LOCATED IN THE SKIN .

THERE ARE FIVE STAGES OF MELANOMA

STAGE 0 STAGE 1 & 2 STAGE 3 STAGE 4MELANOMA IN SITU,

OR AN ABNORMALITY

ON THE EPIDERMAL

REGION OF THE SKIN.

EARLY STAGE,

LOCALIZED

DISEASE.

CANCER THAT HAS

SPREAD TO THE LYMPH

NODES WITHIN THE

REGION OF THE CANCER

OR TO THE LYMPH

VESSELS.

CANCER THAT

HAS SPREAD TO

OTHER MAJOR ORGANS

IN THE BODY.

Dermis

SubcutaneousTissue

Epidermis

AN ESTIMATED

287,700NEW MELANOMA CASES

ARE DIAGNOSED GLOBALLY EACH YEAR.

INCIDENCE OF MELANOMAHAS BEEN INCREASING

FOR AT LEAST

5-YEAR SURVIVAL RATES

20

40

60

80

100

92-97% Stage I

53-81% Stage II

40-78% Stage III

15-20% Stage IV

Source: American Cancer Society 2017

FAMILYHISTORY

AROUND 10% OF ALL PEOPLE WITH MELANOMA HAVE A FAMILY HISTORY

OF THE DISEASE.

SEVERAL ATYPICAL MOLES

MORE THAN 50 COMMON MOLES.

UV RAYEXPOSURE

MELANOMA IS MORE

THAN 20 TIMES MORECOMMON IN WHITES

THAN IN AFRICAN

AMERICANS.THERE ARE A NUMBER OF FACTORS

THAT MAY MEAN YOU ARE

AT A HIGHER RISK FOR

MELANOMA, INCLUDING:

RISKFACTORS

IMMUNOTHERAPY CHEMOTHERAPY RADIATIONTHERAPY

TARGETED DRUG THERAPY

SURGERY

TREATMENT APPROACHESFOR PATIENTS WITH MELANOMA,

SURVIVAL RATES VARY GREATLY

DEPENDING ON THE STAGE OF

DISEASE. FOLLOWING DIAGNOSIS,

OPTIONS MAY INCLUDE ONE OR

MORE APPROACHES, INCLUDING:

MEDIAN AGE

64

70

AT DIAGNOSIS

AT DEATH

MELANOMA REPRESENTS

O1.7%OF THE ESTIMATED

18.1 MILLION NEW CANCER CASES WORLDWIDE.

30YEARS

© 2018 Bristol-Myers Squibb Company