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Pharmaceutical Biomaterials
Department of Pharmaceutical Biomaterials
ABOUT
Description
Pharmaceutical Biomaterials is a multidisciplinary field of study combining Pharmaceutics and Biomaterials. This field, commonly deals with the strategies related to the manipulation of bio-originated or bio-applicable materials. These approaches serve towards diagnosis, treatment and/or prevention of various diseases.
Aims:
Development of novel materials to enhance stability and biocompatibility of medical devices and advanced drug delivery systems.
Development and modernization of the industrial companies dealing with pharmaceutical biomaterials to pave the path for the production of novel intelligent drug delivery systems and biomedical devices.
Training of competent and well educated scientists with spectacular expertise to design, discover, synthesize and develop novel biomaterials in order to prevent, diagnose and treat various diseases.
Implementation of modern high-tech and state of the art approaches (NEMS, MEMS, etc) to the field of Pharmacy.
Admission
The national competent applicants will be selected from the successful students who passed the written entrance exam conducted by the Ministry of Health of the Islamic Republic of Iran. The selected candidate will be interviewed and then be accepted once their ambition, enthusiasm, courage and talents are approved by the admission committee of the department.
The international applicants can apply directly through the corresponding department, where their CV, academic records, achievements, publications as well as enthusiasm, courage and talents will be considered and act accordingly.
Due to interdisciplinary nature of the course, the graduates of different fields of studies including Pharmacy, Medicine, Dentistry, Chemistry, Physics, Biology and related fields can sit for the entrance examination.
The entrance exam will be held at the early summer each year and the selected applicants (twice the capacity of the departments) will be nominated at last one month after the exam. They will be then invited to attend the interview that will be held in late summer. The first semester of the academic year will be started in autumn and last till early winter when the second semester starts. The academic year will be finalized at late spring in the following year. The students are expected to finish their studies in four years unless an unprecedented event occurs when it will be extended to one more year.
Education
Different aspects of materials, systems, approaches, techniques and standards, ethics and managements will be thought to the students in practical, theoretical manner. The course will be taught by the academic experts of the university who are conducting different research projects in different departments. In order to familiarize the students to the real world of Pharmaceutical Biomaterials they are required to visit various private and governmental pharmaceutical companies to learn different aspects of design, production, packaging, quality control involved in the field. Moreover, they will be prepared to establish and fund their own science-based companies, independently.
Educational Strategies, Methods and Techniques
Different from the classic manner of education, the Pharmaceutical Biomaterials was designed in a way to train the most talented students based on the modern education and research protocols. The supervisor and the thesis project will be defined at the beginning of the course through mutual understanding and agreement of student and the supervisor(s). An ongoing communication between the student, tutor and supervisor(s) at the teaching and research phases is the must to achieve the goals designed. Accordingly, brain storming, Journal club, update discussion, problem based education, project design and survey and etc., form the foundation of a dynamic course that will be monitored continuously by the Board of Pharmaceutical Biomaterials of Ministry of the Health.
Student assessment
The scientific progress of the students will be monitored during the course of study by all members of the academics in the department. Based on the nature of different courses, the student will sit for oral and/or written examination during and/or at the end of the semester. Furthermore, there are subjects where the student is required to give a seminar and presentation which will be evaluated by the tutor. Following the completion of the course and getting a minimum total score of 15 out of 20, the student will be directed to sit for the General Transferring Exam (GTE). The successful students who passed the GTE will officially start their research project and pursue their studies towards PhD degree. Following the completion of the thesis research project and approval of the supervisor and assessment committee, the student will defend his/her thesis in an open session before the internal and external referees. Once the referees found the thesis, presentation and defend of the student satisfactory, they will approve awarding PhD degree otherwise, the student might be asked to conduct further research or fail him/her altogether awarding him/her a M.Phil degree.
Members (alphabetically)
Name of the faculty member: Mohammad abdolahad
Academic position: Assistant Professor
Office:
Tel: +98 21 61114307
Email: [email protected]
Name of the faculty member: Hamid Akbari Javar
Academic position: Associate Professor
Office: 1-113
Tel: +98 21
Email: [email protected]
Name of the faculty member: Mohsen Amini
Academic position: Professor
Office: 1- B1 131
Tel: +98 21 66959090
Email: [email protected]
Name of the faculty member: Saeed Balalaie
Academic position: Professor
Office:
Tel: +98 21 22886575
Email: [email protected]
Name of the faculty member: Mojtaba Daghighi
Academic position: Post-Doctoral research fellow
Office:
Tel: +98 21
Email:
Name of the faculty member: Ismaeil Haririan
Academic position: Professor, Head of the Department
Office: 2-110
Tel: + 98 21 66482607
Email: [email protected]
Name of the faculty member: Saman Hosseinkhani
Academic position: Professor
Office:
Tel: + 98 21 44078288
Email: [email protected]
Name of the faculty member: Mehdi Khoobi
Academic position: Assistant Professor
office:
Tel: + 98 21 66482607
Email: [email protected]
Name of the faculty member: Seyed Naser Ostad
Academic position: Professor
Office: 2-314
Tel: + 98 21 66959105
Email: [email protected]
Name of the faculty member: Masoud Soleimani
Academic position :Associate Professor
Office:
Tel: + 98 21 82884508
Email: [email protected]
Courses:
Table A. Core Courses in the Pharmaceutical Biomaterials
Prerequisite or concurrent
courses
Total hours of the coarseCredits Number ofTitle of the
course
Code of the course TotalPracticalTheoreticalTotalPracticalTheoretical
02,03,04343423Pharmaceutical
Biomaterials11
343422
Advanced Cellular & Molecular
Biology
12
513417211Cell Culture13
12, 13343422
BioCompatibility and Biosimilarity
in Pharmaceutical
Biomaterials
14
12, 13343422
BioDegradability in
Pharmaceutical Biomaterials
15
683434312Synthesis & Processing in
Pharmaceutical Biomaterials
17
343422Tissue Sciences & Tissue
Engineering
09
22Thesis
(dissertation)18
37Total
Table B. Non-Core Courses in the Pharmaceutical Biomaterials
Prerequisite or concurrent
courses
Total hours of the coarseCredits Number ofTitle of the course
Code of the
course TotalPracticalTheoreticalTotalPracticalTheoretical
513417211Experimental Design and Research,
19
Development
343422Standardization Techniques in
Pharmaceutical Biomaterials
16
171711Medical Ethics in Pharmaceutical
Biomaterials
21
343422Computational analysis &
Modeling in Pharmaceutical
Biomaterials
22
513417211Bioinformatic in Pharmaceutical
Biomaterials
01
343422Advanced Instrumental
Analysis
24
683434312Smart Pharmaceutical
biomaterials
25
171Nowledge-based companies
14Total
Table C. Compensatory Courses in the Pharmaceutical Biomaterials
Prerequisite or concurrent
courses
Total hours of the coarseCredits Number ofTitle of the courseCode of the
course TotalPracticalTheoreticalTotalPracticalTheoretical
343422Physical Pharmacy(I)
01
343422Physical Pharmacy(ii)
02
515133Biopharmacy & Pharmacokinetics
03
515133Novel systems for Drug transport
04
343422Medical Immunology
07
343422General Pharmacology
08
343422Polymer Science
515133Medical Physiology10
21Total
Research
Main Research Areas:
The research projects will focus on the clinical dilemmas to address the development and therapeutic application of pharmaceutical biomaterials for the prevention and treatment of diseases and biological dysfunction at the systematic whole body, organ, tissue, cellular and molecular levels in experimental and theoretical manner.
In this regards, functionalization, immobilization, and surface chemistry optimization in various in-vitro, in-situ, in-vivo and in-silco models resulting in the development of novel synthetic or natural biocompatible materials.
The main focal points include targeted drug and gene delivery, real time monitoring of cellular metabolic activities and developing appropriate and biocompatible coatings for implants, stents and artificial organs. Furthermore, different living systems such as cells, bacterial and viruses might be served as biomaterials for certain targeted tasks defined by pharmaceutical sciences to overcome cellular and tissue malfunctions occurring in the patients.
Technical approaches
• Development, characterization and evaluation of novel biomaterials for pharmaceutical applications
• Evaluation of interfacial interactions between biomolecules and cells with biomaterials at the molecular and cellular levels (experimental and theoretical approaches)
• Modifications of the materials surface to promote their interactions with the biological tissues to fulfill biomedical applications defined for medical devices, drug, and gene carriers and diagnostic gadgets.
• Application of microfluidic system, lab and cell on chip, organ-on chip, lab-in-cell, electrospining, imprinting, electrochemical means, NEMS (Nano Electro Mechanical Systems) and MEMS (Micro Electro Mechanical Systems)
Ethical issues
• Safety and cautious means involved in working with pharmaceutical biomaterials
• Bioethics of working with biological matters
• Ethical principles involved in education and research
• Ethics of management and personal affairs
• Ethics of disposals and waste products
Contact
For more information about the department of Pharmaceutical Biomaterials, you may contact with:
Name of the faculty member: Mehdi Khoobi
Academic position: Assistant Professor
Office:
Tel: + 98 21 66482607
Email: [email protected]
Available Positions:
New antimicrobial graphene based coatings for biomaterial implants
PhD position is available in the research group of Dr. Ismaeil Haririan at the TUMS School of Pharmacy, Tehran, Iran (http://pharmacyen.tums.ac.ir/en/page/19520/About) and is funded by Iran National Science and National Elite Foundations. We seek to appoint an ambitious and self-motivated PhD student with interest in Material Chemistry, Molecular Biology or Pharmacy.
Job Description:
The project deals with the implant infection which is the major complication of the use of biomaterials implants. Treatment of such infections is difficult and often requiring removal of the device. Antimicrobial coatings are considered a most promising solution, as they entrapped an infectious biofilm between a destructive surface (coating) and the host immune system or antibiotic treatment as an unfriendly body environment. Most importantly, the influence of antimicrobial coatings on biofilm formation should be examined using evaluation methods for directly antimicrobial and immunocompatible coatings, indispensable for development of the other coatings. Although the current evaluation methods remain useful for studying effects of single factors applied on a biomaterials surface but, evaluating combined effects of antimicrobial coatings, systemic antibiotics and the host immune system requires developing novel methods and tools that overcome these limitations and applying these new methods in situ.
The project will be focused on the development of new antimicrobial graphene based coatings also development of improved methods for evaluating antimicrobial and immunocompatible coatings in vitro and in vivo. These methods will be made available for application toward the newly developed coatings. In order to monitor the efficacy of the coatings, novel nanosensors will be used as a tool for monitoring and evaluating combined effects of antimicrobial coatings, systemic antibiotics and the host immune system.
The research will involve several different disciplines spanning from nanoparticle physico-chemical characterization to quantitative host-pathogen interactions studies, with methods such as flow cytometry, and fluorescence imaging. Proteomics will be used in combination with cell biology and molecular biology approaches to characterize and identify the mechanisms involved.
Qualifications and skills:
The successful candidate for this PhD position will have the following qualifications:
A high honors masters' degree in Material Chemistry, Biology, Biomedical Sciences, Pharmacy or related areas
Very good knowledge of written and spoken English and very good communication skills Enthusiasm for research in an interdisciplinary setting and international environment Good communication skills to be able to act as an excellent team player
Previous experience or particular interest in microbiology, cell culture systems, cell biology and/or with nanoparticles would be considered an asset, as also previous experience with biocompatibility of coatings, immunoblotting and proteomic to study cellular processes.
Application:
Applications for the position should include in 1 file the following information:
Short curriculum vitae with details master degree(s); this should include the list of courses attended and transcript(s) of grades, and a short description of previous research experience (such as the master research project)
Motivation letter (max 1 page) Name and (email) address of two professional references
If your profile matches the above description, please send your CV, motivation letter and contact details of two referees in a single pdf file, by email to [email protected].
For further information please contact: Mojtaba Dghighi, e-mail: [email protected]
