Metabolic Syndrome: Focused on AMPK as Molecular Target for

Metabolic SyndromeBayu Lestari

What will be Impaired in This Patient?

Obese

Insulin Resistance?

Dyslipidemia? (High TG, High LDL, Low LDL)

T2DM?

Metabolic Syndrome

High prevalence of metabolic syndrome: relation between glucose and lipid metabolism

Various clinical manifestations: T2DM, obese, dyslipidemia

New therapeutic approach required for efficient and high efficacy

AMPK was reported as potent molecular target for metabolic syndrome therapy

Background

Discuss about Metabolic Syndrome Discuss about AMPK as molecular target for

therapy

Aim

Cluster of syndrome: insulin resistance, high blood glucose, dyslipidemia, obese

Impairment both glucose metabolism and lipid metabolism

Correlation between glucose and lipid metabolism?

Metabolic Syndrome

Glucose Transport and How Insulin Resistance Occur

How Lipid Disorder Affect Insulin Resistance

Structure of AMPK

Activation Pathway of AMPK

Regulation of AMPK

How AMPK Activation Reduce Metabolic Syndrome

Enhanced translocation of GLUT4 Enhanced expression of GLUT4 gene (Zheng

et al, 2009) Insulin independent pathway?

Role AMPK on GLUT4

mTOR Pathway

Insulin-mTOR pathway activation & phosphorylation S6 kinase I, down-regulation insulin receptor substrate-1 (IRS1) decrease insulin signalling (Zheng et al, 2009)

Role AMPK in Insulin Sensitivity

AMPK activation improve mitochondrial function via expression of peroxisome proliferator-activated receptor-γ (PPAR-γ) coactivator-1α (PGC-1α) reduce insulin resistance reduce development of T2DM (Zheng et al, 2009)

Role AMPK in Mitochondrial Biogenesis

Role AMPK in Lipid Metabolism

Lipid Oxidation Lipogenesis

Metabolic syndrome: cluster of syndromes (insulin resistance, dyslipidemia, obese)

AMPK has beneficial role as molecular target for metabolic syndrome’s therapy

Conclusion

Thank You