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METABOLIC SYNDROME
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Aka: Syndrome X; insulin resisan!esyndrome
Consellaion o" mea#oli!a#normaliies $a !on"er in!reased
risk o" C%D
DM
Ma&or 'eaures:
CENTRAL OBESITY
(Y)ERTRI*LYCERIDEMIA
LO+ (DL
(Y)ER*LYCEMIA
(Y)ERTENSION
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E)IDEMIOLO*Y
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RIS, 'ACTORS
O-er.ei/$0o#esiy
Sedenary li"esyle
A/in/
DM
C(D
Li1odysro1$y
Insulin resisan!e
In!reased .ais!ir!um"eren!e
Dysli1idemia
(y1erension
)roin2ammaory
!yokines Adi1one!in
ETIOLO*Y
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Clini!al 'eaures
Ty1i!ally no asso!iaed .i$sym1oms
+ais !ir!um"eren!e may #e e31anded
B) may #e ele-aed
Li1oaro1$y or a!an$osis ni/ri!ans
)(YSICAL EXAM
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C%D
Ty1e 4 Dia#ees
Nonal!o$oli! "ay li-er disease
(y1eruri!emia
)oly!ysi! o-ary syndrome O#sru!i-e slee1 a1nea
ASSOCIATED DISEASES
OT(ER ASSOCIATED CONDITIONS
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LABORATORY TESTS
'asin/ li1ids and /lu!ose
Biomarkers asso!iaed .i$ insulinresisan!e a1oB
(i/$5sensii-iy CR)
'i#rino/en
6ri! a!id
6rinary mi!roal#umin Li-er "un!ion ess
Slee1 sudy
Tesoserone7 L(7 'S(
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TREATMENT
+ei/$ redu!ion Calori! resri!ion7 in!reased 1$ysi!al
a!i-iy and #e$a-ior modi8!aion
9
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+ei/$ loss dru/s A11eie su11resans
)$enermine ? mon$s@
Si#uramine
A#sor1ion in$i#iors Orlisa ?9
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MSDM: >
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>
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MS DM: ACEin$i#iors or An/ioensin IIre!e1or #lo!ker
Li"esyle iner-enion Me"ormin
Bi/uanides7 T$iaHolidinediones7Me"ormin
BLOOD )RESS6RE
IM)AIRED 'ASTIN* *L6COSE
INS6LIN RESISTANCE
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T(AN, YO6J
