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18
The interaction of exposure with age at ob-
servation fits a relative risk model well.
The similarity of these results to a recent
study of Swedish iron miners with similar
levels of relatively low exposure suggests
that exposure to radon daughter products may
be a major contributory factor to lung can-
cer occurring among nonsmokers in the
general population. The results also rein-
force concerns as to the appropriateness of
present occupational exposure standards.
Silicosis and Bronchial Carcinoma: Anatomic
Pathology and Problems in Expertising.
Reitemeyer, E., Bohm, E., Muller, K.-M. In-
stitut fur Pathologie der Berufsgenos-
senschaftlichen Krankenanstalten
'Ber~insheil' - Universitatsklinik, D-4630
Bochum, Germany. Prax. Klin. Pneumol. 39:
679-680, 1985.
Evaluation of 7,122 postmortem findings
in miners with silicosis, obtained during
1964 to 1983, yielded 966 times a combina-
tion of silicosis with bronchial carcinoma
(= 13.6%). According to established
criteria, a silicotic carcinoma in scar
tissue was diagnosed 45 times (4.7% of all
bronchial carcinomas). Statistical com-
parisons alone (age, degree of silicosis,
topography and histological tumour type)
with the silicosis-independent bronchial
carcinoma did not supply any pointers for
diagnosing a silicotic carcinoma in scar
tissue. There are also no statistically
manifest differences in respect of aetiology
and pathogenesis, with the exception of a
cocarcinogenic factor due to the silicotic
scar. Hence, detailed individual morphologi-
cal examination with due consideration being
given to the clinical findings, will always
be necessary in each case for writing a
sickness insurance expertise on a probable
connection between silicosis and a bronchial
carcinoma.
3. BASIC BIOLOGY.
Induction of Squamous Cell Carcinoma in the
Rat Lung by 1,6-dinitropyrene.
Maeda, T., Tzumi, K., Otsuka, H. et al.
Department of Pathology, School of Medicine,
The University of Tokushima, Tokushima 770,
Japan. J. Natl. Cancer Inst. 76: 693-701,
1986.
The carcinogenicity of l-nitropyrene
(I-NP) CAS: 5522-43-0) and 1,6-dinitropyrene
((I,6-DNP) CAS: 42397-64-8) was examined by
their direct injection in a beeswax-
tricaprylin vehicle into the lung of male
F3~/DuCrj rats. Of 28 rats given 0.15 mg of
1,6-DNP, 21 (75%) developed squamous cell
carcinomas, 2 (7%) developed undifferen-
tiated carcinomas, and 2 (7%) had squamous
metaplasias in the lung by 72 weeks. In 32
rats that received 1.5 mg of I-NP, neither
carcinoma nor squamous metaplasia was in-
duced. In all 19 rats (100%) given 0.5 mg of
3-methylcholanthrene (MCA) CAS: 56-49-5),
squamous cell carcinomas were induced ear-
lier than in rats treated with 1,6-DNP. In 1
of 31 rats (3%) given the beeswax-
tricaprylin vehicle only, squamous
metaplasia was induced. Distant metastases
of induced tumors were observed in 4 rats
treated with 1,6-DNP and in 1 rat receiving
MCA. Two lung tumors induced by 1,6-DNP were
successively transplanted into the same
strain of rats for 3 generations.
Metabolism of Benzo(a)pyrene in Monolayer
Cultures of Human Bronchial Epithelial Cells
from a Series of Donors.
Siegfried, J.M., Rudo, K., Bryant, B.J. et
al. Carcinogenesis and Metabolism Branch,
United States Environmental Protection
Agency, Research Triangle Park, NC 27711,
U.S.A. Cancer Res. 46: 4368-4371, 1986.
Benzo(a)pyrene (B(a)P) metabolism was
measure in monolayer cultures of human bron-
chial epithelial cells derived from 18
specimens of explanted tissue. Bronchial
epithelial cells converted B(a)P to
dihydrodiols, phenols, quinone derivatives,
and polyhydroxylated forms. Sulfate and
glufuronide conjugates of B(a)P metabolites
were also detected. Both total metabolism
and distribution of metabolites showed a 10-
fold or greater variation in cultures from
different specimens. When the data were
divided according to smoking status,
however, no differences in total metabolism,
extent of conjugation, or distribution of
metabolites could be demonstrated between
the two groups. Wide variation (over lO00- fold) in the cytotoxicity of B(a)P towards
cells derived from different specimens was
demonstrated but could not be directly
correlated to the extent of metabolic ac-
tivation. The results suggest that human
bronchial epithelial cells which are newly
grown from explanted tissue of smokers in
culture do not demonstrate enzymatic induc-
tion. Variation among individuals observed
in these studies probably represents basal
differences in metabolic capability.