Michigan Difference in Vision

UNIVERSITY OF MICHIGAN KELLOGG EYE CENTER 2008 ANNUAL REPORT

The Michigan Difference in Vision

RESEARCH New Use for Femtosecond Laser: Corneal Transplants . . . . . . . . . . . . . . . . . . . . . 5 50 Years of Cornea Research at Kellogg . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Early Warning for Diabetes Appears in Snapshot of Eye . . . . . . . . . . . . . . . . . . . 7 Study Reveals Gaps in Glaucoma Treatment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Consortium Puts Retinitis Pigmentosa under the Microscope . . . . . . . . . . . . . . . . . 9

EDUCATION Iraq Veteran Hones Skills as Plastics Fellow . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 RetinaDx Goes Live . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 Blueprint Drawn for 21st Century Resident Education Center . . . . . . . . . . . . . . 13 Alums Care for Children Worldwide . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14

PATIENT CARE SurgeryStraightensToddler’sEyes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 On the Road to Independent Living . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 African Teen Has Long Overdue Surgery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19

OUTREACH Big Ten Doctors Go to Vietnam . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 0

GIVING Ravitz Professorship Honors Ophthalmic Pathology . . . . . . . . . . . . . . . . . . . . . . . 2 3 Carls Foundation Ushers in New Era of Pediatric Eye Care . . . . . . . . . . . . . . . . 2 4 Eye Center Expansion Makes Rapid Progress . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 5 Kellogg Eye Center Expansion Honor Roll . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 6 Towsley Foundation Supports Expanded Ophthalmic Imaging Center . . . . . . . 2 8 Fralick Society Recognizes Annual Donors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 9 Chair Receives Top Ophthalmology Award . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 9 Annual Giving Honor Roll . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 0

DEPARTMENT OF OPHTHALMOLOGY AND VISUAL SCIENCES FACULTYFaculty Honors, Recognition and Publications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 4Grants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 4Faculty Photos . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 8

Table of Contents

2008 Annual Report • University of Michigan • W.K. Kellogg Eye Center This report covers the period July 1, 2007 through June 30, 2008

Dear Friends,

The year has been marked by rapid progress on the Kellogg Eye Center Expansion, many new faculty initiatives and research advances, and, as always, exceptional generosity on the part of those who support the Eye Center. In this report, we have the opportunity to highlight the Cornea Service and its contributions to the Department over many years. Among the foremost contribu-tors is Alan Sugar, M.D., nationally known for his leadership in that subspecialty. He is an expert on a complement of corneal disorders and surgeries, including corneal transplantation. He has served for many years as a medical director of the Michigan Eye-Banks, and is principal investigator for the Department’s arm of the Cornea Donor Study, a multi-center study sponsored by the National Eye Institute. Along with others of us, Dr. Sugar was in on early stages of discovery when the Department realized that an industrial laser, the femtosecond laser, could be used

for eye surgery. That research resulted in the commercialization of a new laser for refractive surgery. Now Dr. Sugar and colleagues are investigating that laser’s use for corneal transplantation. Dr. Shahzad Mian leads a pilot study that investigates the femtosecond laser in cutting corneal tissue for the surgery, and he reports early positive outcomes. The Department continues its strong, long-standing reputation for research on retina function and disease. Such research has profound implications for understanding diseases that affect the vision of so many older individuals. As part of a new program initiated by the Foundation Fighting Blindness, several Kellogg scientists and clinicians are collaborating with colleagues from other institutions to create new treatments for retinitis pigmentosa, a disease that results in progressive loss of vision. The collaborative nature of the study is an example of research models now in favor among federal funding agencies. Pediatric ophthalmology at Kellogg has also grown at a record pace over the past several years. Far ahead of its peers, the Department announced in 1985 the nation’s first endowed pediatric ophthalmology chair, held then and now by Dr. Monte Del Monte. Since then we’ve added faculty and many more patients and today our children’s clinics are filled nearly to capacity. When the Eye Center Expansion opens in 2010 we will have a new spacious clinic, thanks to the Carls Foundation. Read about that organization’s generous support in this report. The recurring theme of growth, of course, is what has created the need for a new facility. And so this year, we celebrate the progress made toward the completion of the Eye Center expansion. In late fall we gathered to celebrate the completion of the steel structure and the traditional Topping Out ceremony. Before long the structure was com-pletely enclosed. Now, as the clinics take shape inside and brick and glass appear outside, the new building is beginning to resemble the models and renderings we have viewed for the past couple of years. Each phase of construction brings us nearer to the day when we can realize our goal of having one of the finest, most advanced Eye Centers in the nation. So many individuals and organizations have supported our goals. Our new Fralick Society was formed to recognize annual partners in giving. And organizations like the Towsley Foundation are helping us build and name key components of the building. Take a minute, also, to run through the honor rolls in this report. We recognize and thank our supporters — friends, alumni, faculty and staff — who are committed to the growth of the Eye Center and believe in the power of its research programs to find new treatments for people with blinding eye disease.

Paul R. Lichter, M.D.F. Bruce Fralick Professor and ChairUniversity of Michigan Department of Ophthalmology and Visual SciencesDirector, W.K. Kellogg Eye Center

08

2010 Projected Patient Visits: 139,303

2005 Patient Visits: 119,915



Building on SucceSSIn 1985 the W.K. Kellogg Eye Center opened. This ultra-modern eight-story building allowed us to expand our research and education efforts and our ability to care for patients needing advanced eye care. The new building also allowed us to bring our vision research scientists to a facility where they could easily exchange ideas with clinicians, nurturing the concepts of collaborative and translational research. That same year, 1985, the Eye Center employed 90 faculty and staff. If you follow the expanding circles on the charts below, you’ll see that we grew — in patient visits and in staff and faculty to serve them — beyond our greatest expectations.

In the late 1990s, Chair Paul R. Lichter, M.D., realized that we would outgrow this still seemingly brand new eye care facility. He commissioned a study and by 2005, the Regents of the University of Michigan had approved plans for expansion. When the U-M Kellogg Eye Center expansion opens in 2010, we expect that year’s tally of patient visits will approach 140,000. At the same time, the numbers of faculty and staff will increase to accom-modate our patients and the urgent need to accelerate research efforts toward a cure for eye disease.

UNIVERSITY OF MICHIGAN kellogg eye center 3

Growth in Patient Visits

2010: 512 projected

2005: 410

1995: 198

1985: 90

Faculty and Staff Growth since the W.K. Kellogg Center Opened

2010: 512 projected

2005: 410

1995: 198

1985: 90

$15.5 million raised

$4.5 million to goal

Gifts Toward Research and Endowment

$20 Million Goal

Gifts Toward the New Building



$20 Million Goal




$20 Million Goal

Department Growth in clinics by 2010

27% Comprehensive

8% Contact Lens

20% Pediatric

10% Photography

5% Eye Plastic Neuro

6% Retina

1% Glaucoma


2010: 512 projected

2005: 410

1995: 198

1985: 90



Gifts Toward Research and Endowment

$20 Million Goal




$20 Million Goal




$20 Million Goal

Department Growth in clinics by 2010

27% Comprehensive

8% Contact Lens

20% Pediatric

10% Photography

5% Eye Plastic Neuro

6% Retina

1% Glaucoma


2010: 512 projected

2005: 410

1995: 198

1985: 90

Growth in research spurred the expansion of the Kellogg Eye Center. While our new building will enable us to accelerate efforts toward more effective treatments and cures for eye disease, it will also provide space for the growing number of individuals seeking eye care. Patients, faculty, staff, alumni, and the community have generously supported the building campaign. Reaching our fundraising goals will ensure we can make the most of this unique moment in our history.

2010 Expansion230,000 sq. ft.

1985 W.K. Kellogg Eye CenterResearch Tower and Clinic Building147,442 sq. ft.

In the spring of 2010, all clinics and surgical suites will move into the new U-M Kellogg Eye Center expansion. Research laboratories will be located in the Kellogg Research Tower (left) and in the upper floors of the new facility.

Accelerating Research

Through collaboration and

individual effort, our scientists

are achieving new insights into

eye disease and treatment

strategies. Their goal is to bring

the best new therapies — and

hope — to our patients and

their families.

Shahzad I. Mian, M.D.

ACCELERATING research 5

FEMTOSECOND LASER COULD CHANGE CORNEAL TRANSPLANT SURGERYEarly results show laser — developed at U-M for eye surgeries — improving corneal

transplant outcomes

Nearly 15 years ago, researchers at Kellogg were first to discover that the ultrafast or femtosecond laser, then used for industrial purposes, had great potential for eye surgeries that traditionally required a surgical blade. Faculty from Kellogg and the College of Engineering explored the laser’s surgical applications, and today it is used worldwide for LASIK surgery. Now, faculty hope for the same success in apply-ing this exceptionally fast and precise laser to corneal transplant surgery. Physician–scientists at Kellogg are conducting a two-year pilot program — called the FLAK (Femtosec-ond Laser-Assisted Keratoplasty) study — which uses the femtosecond laser to perform full thickness corneal transplants. “We hope that with the use of the femtosecond laser, patients will have better vision, faster recovery of vision, and stronger wound construction that will provide more resistance to injury in the future,” says Shahzad I. Mian, M.D., assistant professor and Principal Investigator of the FLAK study. While lasers have been effective in eye surgeries for decades, they were not used for corneal transplants until the femtosecond laser was shown to be a supe-rior cutting tool to the trephine, the cookie cutter-like knife currently used for transplants. “The advantage of this laser is that it allows the surgeon to focus the laser energy at a particular depth and then rapidly cut the tissue at that depth without causing any injury to the surrounding tissue,” says Dr. Mian. “It also allows the surgeon to pattern these cuts into shapes — such as a mushroom, a top hat or a zig zag — that allow for customized overlap between the donor’s corneal tissue and the patient’s corneal tissue.”

Because of the speed and precision of the femtosecond laser, the study results to date for corneal trans-plant surgery have been very encouraging, according to Dr. Mian. If these results hold true, a larger, multicenter clinical trial comparing this procedure to the traditional method could follow. The cornea is the clear, dome-shaped tissue cover-ing the front of the eye. It is about the size of a dime and the thickness of a credit card. If the cornea becomes distorted in shape, or scarred or hazy from disease or injury, the light rays passing through it are distorted and vision is reduced. In some cases, corneal transplant surgery is necessary to replace the damaged cornea with a healthy donor cornea to restore good vision. Ophthalmologists perform more than 35,000 of these sight-saving procedures each year in the United States and, of all transplant surgeries done today, corneal transplants are the most common and most successful. Donor corneas are provided by eye banks and come from deceased individuals who arranged for donation prior to death or whose families gave consent.

“We hope that with the use of the femtosecond laser,

patients will have better vision, faster recovery of vision,

and stronger wound construction ...”— Shahzad I. Mian, M.D.

Corneal transplant patient, Gary Abud, with clinic coordinator, Satavisha Dutta.

UNIVERSITY OF MICHIGAN kellogg eye center6

KEllogg’ShiSToricalrolEIN CORNEAL TRANSPLANTATIONExpanding the donor pool, improving success of transplants

For years, U-M Kellogg Eye Center faculty have played a significant role in corneal transplantation. Kellogg ophthalmologists helped to establish the Michigan Eye-Bank in 1957, which resided in the Kellogg Eye Center until 2006. Faculty members have long collaborated with the Eye-Bank on research. In one recent example, Alan Sugar, M.D., cornea surgeon and professor of ophthalmol-ogy, led the Kellogg arm of a national study on cornea donor tissue.

The study, sponsored by the National Eye Institute with tissue provided by the Midwest Eye-Banks, found strong support for raising the age limit for donors. A key finding of the study: the pool of corneal transplant donors — often limited to those 65 years of age and younger — should be expanded to include donors up to 75 years of age. According to the Cornea Donor Study, the success rate was the same whether the transplants were per-formed with corneas from donors ages 12 to 65 years or from donors ages 66 to 75. “This study indicates that corneas from older individuals are just as successful for corneal transplan-tation as those from younger donors,” said Dr. Sugar. He observes that in addition to expanding the pool of cornea donors, the study will help surgeons learn more about the procedure itself. “The study team is analyzing additional data that will help us understand more fully the factors involved in a successful cornea transplant,” he said. The Cornea Donor Study will continue for another five years, allowing more time to follow

patients and interpret data. At the same time, cornea specialist Roni M. Shtein, M.D., is looking at another important aspect of corneal transplantation. One of the biggest concerns for patient and physician is that the new tissue will be rejected. In her study, Dr. Shtein will identify the characteristics of a patient’s cornea that could predict rejection of the new tissue. Specifically she will examine patterns of corneal neovascularization — the growth of blood vessels in the cornea — which is normally clear. In the first phase of the study she will determine the best way to measure these patterns. In the next and larger portion of the study, Dr. Shtein will develop ways to analyze charac-teristics of corneal neovascularization that can predict rejection or failure of the transplant. “This study is very specific in that it will allow us to identify high risk blood vessels,” says Dr. Shtein. “There is a great deal of interest now in medications used to treat excessive blood vessels in retinal diseases like diabetic retinopathy and wet macular degeneration. Perhaps these drugs, with some modification, could one day help reduce the risk of corneal transplant rejection,” she adds.

Dr. Sugar led a team that studied age of cornea donors.

Dr. Shtein searches for ways to predict whether a cornea will be rejected after a transplant.

“This study indicates that corneas from older individuals

are just as successful for corneal transplantation as

those from younger donors.”— Alan Sugar, M.D.


SCREENING FOR DIABETES WITH RETINAL IMAGING“Snapshots” of the eyes may give early warning of diabetes and related eye disease

A new vision screening device could give physicians and patients a head start on treating diabetes and its vision complications. The instrument, invented by two Kellogg scientists, captures images of the eye that show meta-bolic stress and the tissue damage that occur before the first symptoms of disease are evident. The camera-like instrument can detect this damage earlier than any cur-rent clinical method. For people with diabetes — diagnosed or not — the new device could offer potentially significant advan- tages over blood glucose testing, the “gold standard” for diabetes detection. It is non-invasive and takes about five minutes to scan both eyes. Used as a first- line screening test, the device would indicate whether a patient should proceed with additional testing.

In the July issue of Archives of Ophthalmology, Victor M. Elner, M.D., Ph.D., and Howard R. Petty, Ph.D., report on the potential of the new instrument to screen for diabetes. “Technology that can detect the earliest signs of diabetes gives us a new way to tackle a growing public health concern,” says Dr. Elner. “Early detection and treatment are critical in controlling the disease and its many complications.” He points out that 24 million Americans have diabetes and an additional 57 million have abnormal blood sugar levels that qualify as pre-diabetes. Some of these individuals will develop diabetic retinopathy, an eye disease that affects 4.1 million people and can cause blindness. The instrument can detect metabolic stress, and therefore disease, by measuring the intensity of cellular fluorescence in retinal tissue. This is the second study in which Drs. Petty and Elner reported that high levels of flavoprotein autofluorescence (FA) are reliable indica-tors of eye disease. Dr. Petty, a biophysicist and imaging expert, ex-plains that hyperglycemia — or high blood sugar —

is known to induce cell death in diabetic tissue soon after the onset of disease but before symptoms can be detected clinically. “Increased FA activity is the earli-est indicator that cell death has occurred and tissue is beginning to break down,” says Dr. Petty. People with diabetes might take better care of them-selves once they receive results from this kind of testing, suggests Dr. Petty. “A patient who understands that body tissue is being destroyed may be newly motivated to step up efforts to manage the disease,” he says. In the study, Drs. Elner and Petty measured FA levels of 21 individuals with diabe-tes and compared the results to age-matched healthy controls. The Kellogg scien-tists found that FA activity was significantly higher for those with diabetes, regard-less of severity, compared to those who did not have the disease. Similarly, individuals with diabetic retinopa-thy had much higher FA activity compared to diabetic patients without any visible eye disease. The study also suggests that FA levels can be used to monitor the severity of the disease and the ability of treatments to stem tissue damage. Dr. Elner is a Research to Prevent Blindness Senior Scientific Investigator. The researchers have formed a company, OcuSciences, Inc., to commercialize the metabolic imaging instrument.

Dr. Petty and Dr. Elner review data suggesting early signs of diabetes.

“Technology that can

detect the earliest signs

of diabetes gives us a new

way to tackle a growing

public health concern.”

— VICTOR M. ELNER, M.D., PH.D.


TRENDS IN HEALTH CARE EMERGE FROM CLAIMS DATAOne troubling finding: many with glaucoma are not receiving treatment

It appears that many older adults are not getting the treatment they need for a common form of glaucoma, according to a recent study. And perhaps more trou-bling, the data suggest that both nonwhite and low- income individuals are less likely to receive treatment. For glaucoma specialist and author of the study Joshua D. Stein, M.D., M.S., these numbers are dis-turbing. Prompt and sustained treatment is essential

for preventing loss of vision from glaucoma, a group of eye diseases causing damage to the optic nerve. Once damage occurs, vision loss cannot be restored. The findings come from an analysis of a database with information on ser-vices provided to Medicare beneficiaries over a ten-year period, from 1992 to 2002. Dr. Stein and his colleagues identified 6400 individuals, all 65 years of age or older, who had received a diagno-sis of primary open-angle glaucoma (POAG). The most common form of glaucoma,

POAG can silently and progressively destroy vision before symptoms are noticed. The study is one of several of Dr. Stein’s research projects in which he analyzes data from large health care databases to flesh out patterns of health care. For example, by studying large groups he can determine how frequently people use medical services, which med-ications are prescribed for them, which tests have been ordered, and other factors important in shaping health policy. “There’s a wealth of information available in these data sets,” he explains. “We just need to tap into

the data, make sense of the patterns, and, ultimately, use the information to improve care for our patients.” The current study, published in Ophthalmology, reported that nearly 30 percent of patients with glau-coma received neither medical nor surgical treatment. Dr. Stein further observed that those with Medicaid, a program for needy and low-income individuals, were 43 percent less likely to receive care for glaucoma. Another troubling statistic, he added, is that Hispanics, Asians and patients from other minority groups were all less likely than non-Hispanic whites to receive treatment. Now, says Dr. Stein, we need further studies to explain why these individuals aren’t receiving proper medical care. “Is access to health care the biggest problem, or is cost the obstacle? Perhaps there are bar-riers to communication,” he says. The answers to these questions could help more people with glaucoma get the care they need. The study also examined which glaucoma drugs are most frequently prescribed. And Dr. Stein says there is always debate about new and preferred treatments. But, he adds, “As important as it is to look for new glau-coma therapies, if we could just concentrate on getting people to take advantage of the treatments we already have, we would save a lot of vision.”

“There’s a wealth of

information available

in these data sets. We

just need to tap into

the data, make sense

of the patterns, and,

ultimately, use the

information to improve

care for our patients.”

— JOSHUA D. STEIN, M.D., M.S.

“As important as it is to look for new methods, if we just

concentrate on getting people to come for the treatments

we have, we can save a lot of vision.”— Joshua D. Stein, M.D., M.S.

Dr. Stein crunched the numbers in a national database to learn more about glaucoma treatment.


CONSORTIUM SEEKS ANSWERS ON RPIs there more than one way to rescue a photoreceptor?

Scientists and physicians from three universities are teaming up to develop therapies for an inherited retinal degenerative eye disease. Funded by the Foundation Fighting Blindness (FFB), the project brings together the best minds from various disciplines and perspectives to collaborate on treatments for X-linked retinitis pigmentosa (XLRP). A patient with XLRP has gener-ously underwritten the research. Together the team will explore a variety of therapeutic approaches, all intended to replace or rescue dying photoreceptors. Of the seven team members, five are from the U-M Kellogg Eye Center. Collaboration is becoming an increasingly favored approach in research, says Debra A. Thompson, Ph.D., who will direct one section of the study. She points to recent results of a small study in which patients regained some vision after receiving gene therapy for a degenerative eye disease. “With this stun-ning success for patients with the RPE65 mutation, we now have evidence that similar approaches could work for a larger group of patients whose vision is compro-mised by other genetic mutations.” Retinitis pigmentosa is a group of diseases that cause slow but progressive loss of vision usually over decades. The designation “X-linked” means that the mutation responsible for the disease is carried on the X chromosome. Simply stated, this disorder results in the loss of photoreceptors, the rods and cones responsible for vision. Scientists who make up the FFB Consortium will explore different strategies for restoring the func-tion of photoreceptors and preventing their loss. The project initially centers on a mouse model of XLRP identified by Kellogg’s John R. Heckenlively, M.D., in collaboration with the Jackson Laboratory. The model, known as rd9, has the same gene and type of mutations as seen in humans with XLRP. Using this mouse model, Hemant Khanna, Ph.D., and David N. Zacks, M.D., Ph.D., will explore whether cell-replacement therapy is an effective strategy for restoring lost vision. They will transplant healthy pho-toreceptor rods into the retinas of the diseased mice, with the goal of achieving at least partial recovery of

the rods’ ability to function. This builds on the work of Anand Swaroop, Ph.D., now a senior scientist at the National Eye Institute, whose work at Kellogg led to successful transplantation of rod precursor cells into blind mice in 2006. Dr. Swaroop, whose lab identified a key mutation in the RPGR gene, was the driving force behind the creation of the Consortium. Taking another tack, researchers at the University of Pennsylvania and the University of Florida will seek to repair photoreceptor damage by delivering thera-peutic or “healthy” forms of the RPGR gene into the retina. They will investigate strategies using modified viruses that act as vectors to carry a replacement copy of the affected gene. The replacement genetic material was constructed at Kellogg by Dr. Khanna’s laboratory. While gene delivery using viral vectors has been successful in treating certain degenerative eye diseases, Kellogg’s Dr. Thompson observes that there are still lingering concerns about the safety of the approach. She is exploring alternate methods, involving the deliv-ery into the eye of small molecules expected to rescue failing photoreceptor physiology affected by the RPGR mutation. Dr. Heckenlively, who sees patients with a range of inherited retinal diseases, and whose project found over 100 mouse models of human eye disease, will evaluate the effectiveness of each approach. Dr. Heckenlively will review fundus photographs and ERG recordings to see how close each approach has come to the collective goal of rescuing photoreceptors.

Hemant Khanna, Ph.D., John Heckenlively, M.D., David Zacks, M.D., Ph.D., (standing) and Naheed Khan, Ph.D., Debra Thompson, Ph.D., (seated) are on the Michigan team

studying retinitis pigmentosa.

Investing in Education

By expanding our educational

and training programs, we

attract the best and brightest

residents, clinical fellows, and

postdoctoral research fellows.

They go on to careers in

ophthalmology and vision

science, serving as leaders here

and around the world.

Christine C. Nelson, M.D. and Raymond Cho, M.D.

INVESTING IN eDUcatIon 11

KELLOGG FELLOW IS BATTLE TESTED

Physician who served in Iraq comes to Kellogg to hone his ophthalmic

plastic surgery skills

Lieutenant Colonel Raymond Cho, M.D. served in Iraq from November 2005 through April 2006. During that time, more than 90 percent of Dr. Cho’s patients were trauma victims — soldiers and civilians with ruptured eyes, facial fractures, and soft tissue trauma. After an intense time repairing eye damage caused by roadside bombs and improvised explosive devices, Dr. Cho came to Kellogg in 2007 to advance his clinical and surgical skills. He is now Kellogg’s fellow on the Eye Plastic, Orbital and Facial Cosmetic Surgery Service. Kellogg’s fellowship programs, among the best in the nation, allow physicians to train in a clinical program known for depth and excellence in each sub-specialty. During the two-year oculoplastics program, fellows gain extensive experience in diagnosis, surgical management, pre- and postoperative care and manage-ment of patients with eye plastic and orbital disorders and diseases. “This fellowship at Kellogg has been a perfect fit for me,” says Dr. Cho. “I am particularly grateful for the time and effort which all of the faculty continually invest in my development as an oculoplastic surgeon. It has been an excellent program which will undoubt-edly prepare me for the cases I will see in the future.” That training has included unusual and complex cases referred to Kellogg from far and wide. Dr. Cho’s mentors and colleagues at Kellogg are quick to praise him. “He is a compassionate physician, superb surgeon and has a humanitarian outlook,” says Christine C. Nelson, M.D., associate professor. “He is an inspiration to us all. His calm demeanor is refresh-ing, he is a pleasure to work with, and he is a wonderful teacher and mentor to the residents.” Before coming to Kellogg, Dr. Cho chose to follow the path of his father and brother and enrolled in the United States Military Academy at West Point for his

undergraduate degree. The Ohio native went on to the University of Cincinnati for medical school and com-pleted his surgical internship at Brooke Army Medical Center in San Antonio. He then spent three years in the 82nd Airborne Division at Fort Bragg, North Carolina. He returned to Brooke for his residency, after which he was assigned first to Fort Knox, Kentucky, and later to West Point. As the only ophthalmologist at these military bases, Dr. Cho handled a variety of cases. “Working as the lone ophthalmologist taught me valu-able organizational skills and helped me build a strong base in ophthalmology before moving on to a subspe-cialty,” says Dr. Cho. When the military introduced its Warfighter Refrac-tive Eye Surgery Program in 2001, Dr. Cho’s ophthal-mology repertoire expanded. He started a laser surgery program both at Fort Knox and at West Point. Once Dr. Cho completes his fellowship at Kellogg in 2009, he will go to one of the Army’s academic medical centers to train residents and handle the oculo-plastics needs of the Army, including reconstructive eye surgeries for soldiers returning from combat.

“I am particularly grateful for the time and effort which

all of the faculty continually invest in my development

as an oculoplastic surgeon.”— Raymond Cho, M.D.

West Point graduate, Dr. Raymond Cho, served in Iraq before joining Kellogg for his two-year ophthalmic plastics fellowship.


RETINADx GOES LIVE An educational web site alsoinvites dialogue

Looking back at their residency training, most ophthalmologists remember, somewhat fondly, the “fluorescein conference” as an effective way to learn about retinal diseases. At professional meetings, retina specialists have found the same kind of forum to be among the most popular and thought-provoking. Physicians present in-teresting cases of retinal disease and then engage in animated discussions on possible diagnoses and treatments. David N. Zacks, M.D., Ph.D., a retina specialist at the Kellogg Eye Center, is creating the same spirit on a new web site — RetinaDx — with nearly 140 retina cases accompanied by spectacular images. For each case there is a brief history and presentation of findings, fol-

lowed by retina photographs and diagnostic images and studies. In addition to the diagnosis and the differen-tial diagnosis, key teach-ing points — that is, “take home” messages that can be applied when the physi-cian encounters patients with similar symptoms — are included. Each case also has a section where users can post their comments.

Dr. Zacks’ original intent was to create an educa-tional site for medical students, residents and retina fellows. He believed that a comprehensive review of retina cases would be especially helpful during their training or when studying for Boards. But as the site evolved he envisioned yet another use — a forum where specialists could share insights and problem cases. “So often physicians see a rare, isolated case and would benefit by talking with others who have encountered the same,” he says. “Now they can submit the one-of-a-kind case and invite comments from their peers.”

An additional unforeseen benefit is the ease with which physicians will be able to collaborate on publica-tions. As clusters of cases on rare conditions appear on RetinaDx, the contributing doctors could seek out each other and collaborate on case reports for ophthal-mology journals. The site has grown since fall 2005 when Dr. Zacks first asked residents to submit cases during their rota-tion in Kellogg’s Retina Clinic. As favorable feedback came in, Dr. Zacks sought ways to make the site bigger and better. He reached out to his colleagues in other ophthalmology departments and has gathered an im-pressive Advisory Board. With feedback from the Board and users of the site, he expects RetinaDx to generate discussion and serve as a central gathering place for the retina community. Students, trainees and ophthalmologists are encour-aged to view the site and to join in the discussion by offering feedback and posting comments on cases at www.kellogg.umich.edu/retinadx.

Dr. Zacks created a web program where doctors can review complex retinal cases, as well as submit their own.

“So often physicians see

a rare, isolated case and

would benefit by talking

with others who have

encountered the same.”

— DAVID N. ZACKS, M.D., PH.D.

This fundus photograph shows the uncommon combination of choroidal neovascularization, angioid streaks and optic nerve head drusen that

led to the diagnosis of pseudoxanthoma elasticum.

INVESTING IN eDUcatIon 13

A CENTER FOR ExCELLENCEKellogg expansion leads to dedicated, high-tech space for residents

With a goal of providing the best possible education to future ophthalmologists, the Department’s residency training program is designing a new 2,000-square-foot center that will feature state-of-the-art educational and communications technology as well as spaces to learn and interact with colleagues. “This project will create a cohesive, comprehensive space for resident education, and that’s important,” says Residency Director Shahzad I. Mian, M.D. “We have one of the top residency programs in the country, and enhancing our teaching environment will help us build on that. We are bringing together resources and technology that will enable residents to get the most out of their training here.” The Resident Education Center, which will be housed on the sixth floor of the current Kellogg Eye Center tower, will include:

•Alargeconferenceroomequippedwithavariety of communication technologies and flexible fur-nishings that will accommodate conference table, classroom, or lecture-style seating

•Asurgicalskillslaboratoryandsurgerysimulator•Apathologyteachinglaboratory

•Laboratoryspaceforresearchandeducationaltraining

•Aresidentsloungeandworkarea•CloseproximitytoKellogg’sJohnW.Henderson

Library and to the residency program’s administrative offices

“The teaching part of this center, including the surgical skills laboratory and surgery simulator, will be very helpful during all aspects of a resident’s training,” says Sunir J. Garg, M.D., who completed his training at Kellogg in 2002 and now serves on the Department’s Alumni Advisory Board. He is an assistant professor of ophthalmology at Wills Eye Hospital in Philadelphia. “Faculty members always appreciate when residents invest time in their own surgical development and research efforts.” The new center also includes a comfortable space for independent study or small group meetings as well as space for rest during on-call duty. The residents lounge will have a direct video link to Kellogg’s operating rooms, so residents can view surgeries at any time, without having to add traffic to the operating room environment. “Part of the experience of a residency is making friends with your classmates, many of whom you will see at meetings for the next 35 years,” Dr. Garg says. “Having a place to congregate as a group, both to trade notes on diagnostic and surgical techniques, and to have a chance to relax, makes training that much more memorable.”

“We have one of the top residency programs in the country,

and enhancing our teaching environment

will help us build on that.”— Shahzad I. Mian, M.D.

Newly designed space for residents and fellows can be adapted for a variety of learning experiences and will include state-of-the-art instructional laboratories.

Arizona Michael a. Pachtman, M.D.

Arizona Pediatric Eye Specialists

Mesa, Arizona

Completed residency in 1982

Dr. Pachtman’s drive to do his

best for patients has it

s roots

in Ann Arbor, he says. “We were

encouraged to constantly striv

e to

provide the highest leve

l of care in

a compassionate and professio

nal

manner.” Today the managing part-

ner of a 9-physician gro

up prac-

tice that specializes in

pediatric

ophthalmology and adult strabis-

mus, Dr. Pachtman is proud that

his practice makes subspecialty

pediatric ophthalmic care easil

y

accessible to children in

Arizona,

regardless of their soci

oeconomic

or immigration status.

alums care for children Worldwideresidents and fellows who train at the kellogg eye center see a wide range of challenging pediatric cases. the experience enables them to gain the skills they need to treat childhood eye diseases in rural and urban areas in the United states and around the world. those profiled here offer a snapshot of that impact.

Jennifer simpson, M.D.Associate Professor

Chief of Pediatric Ophthalmology and

Adult Strabismus, and Residency Director

University of California Irvine Eye InstituteCompleted fellowship in 1999

Restoring or preserving vision in children

has an impact that lasts a lifetime for

patients, and that’s extremely rewarding,

says Dr. Simpson. As residency direc-

tor at the University of California Irvine

Eye Institute, she is training others to

make that kind of difference as well.

Dr. Simpson credits Kellogg with help-

ing her build a strong residency program

in her growing department. “Learning in an

environment with such high standards

for patient care, education, and teaching

provided me with a template from which

to build my own academic practice,” she

says. In addition to her teaching and

clinical duties, Dr. Simpson’s research

involves the evaluation of novel thera-

peutics for cystinosis, a rare disease

affecting children’s vision.

California

Idaho

katherine a. lee, M.D., Ph.D.

Private Practice

Boise, Idaho


It was during a rotatio

n in Kellogg’s

pediatric op

hthalmology

clinic that D

r. Lee realize

d that working

with children

would

keep her smiling—even ro

utine tasks w

ere fun. “It was a k

ick

to examine kid

s and be ent

ertaining at t

he same time,” she

says. “I enjoy

children beca

use interaction

with them is

unscripted and

they are of

ten delightfu

lly funny.” With on

ly

three pediatr

ic ophthalmologist

s in Idaho,

Dr. Lee provide

s

a wide breadth o

f services so

that her you

ng patients d

on’t

have to travel

too often f

or care. She als

o serves on

the

executive committee f

or the National

Eye Institu

te’s Pedi-

atric Eye Disease

Investigator G

roup and has tak

en on lead-

ership posit

ions in profe

ssional organ

izations.

robert l. estes, M.D.

Associate Professor of Ophthalmology

Vanderbilt Eye Institute

Nashville, Tennessee


Dr. Estes is one of three pediatric

ophthalmologists at Vanderbilt Eye

Institute. He has won four resident

teaching awards in the last nine years.

Because he trains others, he is able to

pass on the commitment to excellence

that is emphasized at the University of

Michigan, multiplying our reach many

times over. “My residency experience at

the University of Michigan is the foun-

dation on which my career has been

based, intellectually, technically, philo-

sophically, and ethically,” he says.

Ten

nes

see

Singaporeseo Wei leo, M.D.

Head of Pediatric Ophthalmology and Strabismus

The Eye Institute, National Healthcare GroupSingapore

Completed fellowship in 2005

Coming from Singapore to Michigan to complete a fellowship

at the Kellogg Eye Center wasn’t easy for Dr. Leo because

of paperwork and family ties. But the clinical and surgical

experience she gained made the effort more than worthwhile,

she says. In Singapore, she leads a pediatric ophthalmology

and strabismus service for the National Healthcare Group, a

public health care entity that serves 3 million people. “I enjoy

helping patients, especially the very young ones, who really

depend on the doctor’s clinical acumen to diagnose and treat

them,” she says. Dr. Leo also holds an academic position at

the National University of Singapore.

Advancing Patient Care

Our patients have come to expect

exceptional care and access to

the newest and best treatments

for eye disease. At Kellogg they

will find doctors who are leaders

in their subspecialties and who

also have time to offer a smile

and words of encouragement.

Erika M. Levin, M.D.

ADVANCING PatIent care 17

GETTING IT STRAIGHTENED OUTPediatric ophthalmologist improves the vision of Kellogg’s youngest patients

No parents want to hear that their child needs surgery. However, when a child has strabismus — a visual disor-der in which the eyes are misaligned and point in differ-ent directions — sometimes surgery is the only treatment that works. Such was the case for Derek and Rebecca Najarian and their 21-month-old daughter, Olivia, from Pinckney, Michigan. “It was the first surgery on our first child and we were scared,” says Mrs. Najarian. “But Dr. Levin treated us well every step of the way. She answered every ques-tion and explained each step of the process. We grew more and more comfortable, and, in the end, she really put our minds at ease.” Erika M. Levin, M.D., a pediatric ophthalmologist at Kellogg, first saw Olivia in May 2003, when she was just 16 months old. Olivia’s pediatrician noticed the strabismus at her 15-month well-child visit and referred her to Dr. Levin in Kellogg’s Brighton office. “When I first met Olivia, she was crying,” says Dr. Levin. “I wasn’t sure if she was nervous or scared, but we were able to work through the tears. I sang to her, worked quickly and we got the job done.” Even though Olivia was too young to read an eye chart, Dr. Levin was able to examine her using finger puppets, mechanical toys and other equipment. Olivia had esotropia (inward turning of the eyes), amblyopia (a “lazy eye” or poorly-seeing eye) and some far-sightedness. Dr. Levin first recommended glasses because they can sometimes help straighten the eyes in children with esotropia and farsightedness. This was not the case with Olivia. Dr. Levin also patched Olivia’s stronger eye to strengthen the vision in her weaker eye. Once her vision was equal and her misalignment was stable, Olivia was ready for surgery. The goal in treating strabismus — a condition affecting 4 percent of children in the United States — is to straighten the eyes so they can be used together. With normal alignment, both eyes aim at the same spot. When one eye is out of alignment, two different images are sent to the brain. While adults would suffer from double vision, a child’s brain simply ignores the image from the misaligned eye. Correcting the misalignment

early increases the chances of developing or regaining stereoscopic vision. If glasses aren’t effective, surgery — or a combination of glasses and surgery — is recom-mended. In September 2003, when Olivia was 21 months old, she underwent success-ful strabismus surgery with Dr. Levin repositioning her inner eye muscles. She went home the same day, with-out any special bandages or patches, and returned to normal activities within a few days. Two months later, Olivia’s eyes were perfectly aligned. Her amblyopia hadn’t returned so she didn’t require further patching. Now, at 6 years old, Olivia sees 20/30 in each eye without glasses and her eyes remain straight. She returns to Kellogg once a year for a follow-up appoint-ment, a visit Dr. Levin eagerly awaits. “One of the best things about being a pediatric oph-thalmologist is seeing patients like Olivia grow and de-velop over the years,” says Dr. Levin. “It’s so rewarding to know that I’ve had a positive impact on my patients’ lives and on their families’ lives, too. I’m thrilled I can do that for them.”

“It was the first surgery

on our first child and

we were scared. But

Dr. Levin treated us

well every step of the

way, and, in the end,

she really put our minds

at ease.”

— MS. REBECCA NAJARIAN

Dr. Levin heard “proof positve” of the successful surgery. When Olivia and her parents went to Disney World, her improved vision allowed Olivia to see Mickey Mouse

“jump” out of the 3-D movie and greet the children.


THE ROAD TO INDEPENDENCELow Vision Clinic helps patients make the most of their limited vision

In 1992, Jeff Crawford came to the U-M Kellogg Eye Center’s Low Vision Clinic with one goal: he wanted to improve his vision so he could earn his driver’s license. He was tired of taking the bus or relying on family and friends to drive him where he needed to go. After working with low vision specialist Donna M. Wicker, O.D., Mr. Crawford achieved his goal and — at age 28 — obtained his first license. He promptly bought a bright yellow Jeep Wrangler. “I figured that if I had any trouble seeing other drivers, at least they would be able to see me,” Mr. Crawford says, laughing. Kellogg’s Low Vision Clinic helps patients with vision loss ranging from mild impairment to legal blindness. These people typically suffer from macu-lar degeneration, diabetic retinopathy, glaucoma and retinitis pigmentosa. Mr. Crawford is typical of many patients with low vision — a term that denotes vision that is 20/70 or less with the best conventional glasses prescription. Many come to their first appointment with specific goals, such as improving their ability to tackle tasks like meal preparation, reading, driving, writing checks and paying bills. “When patients come to our clinic, we discuss specific tasks they would like to accomplish or the ones that give them trouble,” explains Dr. Wicker. “Our job then is to test their vision and optimize their remaining functional vision with the use of optical devices, elec-tronic devices and training techniques.” What patients need most are devices that can mag-nify the objects and material they encounter every day. Among these are high-power reading glasses, telescopes, and handheld and stand magnifiers. Other devices include special telephones and modified closed circuit televisions that enlarge reading material and project it onto a TV monitor. Non-optical devices include large-print items and talking clocks and watches. It was the telescope that allowed Mr. Crawford to get that first driver’s license. Because he is legally blind due to congenital cataracts and aniridia (an absent or partially absent iris), he uses bioptic telescopes — minia-

ture telescopes attached to the top of his eyeglasses — to help him drive. The low vision specialists see about 20 patients each week, most referred by Kellogg’s clinics and com-munity offices. “Kellogg embraces a multi-disciplinary approach to the treatment of low vision,” explains Dr. Wicker. “We have a team of ophthalmologists, optometrists and occupational therapists working together to meet each patient’s needs.” A low vision patient typically has one to four appointments. The last is an optional in-home visit by occupational therapist Karen Murphy, who helps patients with lighting, safety, contrast and organization. Mr. Crawford, now 44, returns to Kellogg each year for a check-up with his ophthalmologist and sees Dr. Wicker if his vision has changed. “Dr. Wicker and the low vision staff are very pro-fessional and friendly and always are concerned about your well-being,” says Mr. Crawford. “The honesty and integrity at Kellogg are phenomenal.” Thanks to Kellogg, Mr. Crawford can drive to his job of 14 years. He is a machine operator for Edwards Brothers, a book and journal manufacturing company in Ann Arbor. “Kellogg gave me back my freedom and indepen-dence,” he states, proudly.

Jeff Crawford credits Dr. Wicker for helping him live and work on his own terms.

ADVANCING PatIent care 19

RECONSTRUCTING THE ORBIT — andaYoungBoY’SFuTurEOculoplastics service built on teamwork, tough cases

Taiwo Bilesanmi, now a teenager, lost his eye to cancer when he was just one year old and living in Nigeria. His family did not have access to a surgeon who could re-build the child’s orbit, the bones and muscles that form the eye’s support. The proper supporting structure was essential if Taiwo were, one day, to have a new pros-thetic eye created for him. Reconstructive surgery can make a big difference in people’s lives, observes Kellogg oculoplastic surgeon Alon Kahana, M.D., Ph.D. At first, Taiwo was too young to care about the loss of his eye, according to his father. But as he grew older, he became sensitive to comments from his friends about his appearance. By the time Taiwo came to the Kellogg Eye Center for orbital reconstruction, the young boy was anxious, but ready for surgery that would allow him to have a new eye. Dr. Kahana was aware the surgery would not be simple. Taiwo, whose family now lives in Detroit, had gone for some 12 years without an eye or prosthesis, and as a result, the orbit had become malformed. Much of the supporting tissue was lost, and the bony structure had grown inward, displacing a silicone implant from an earlier surgery and making it impossible to fit a pros-thetic eye. There was one more obstacle, this one concerned with safety. Before Dr. Kahana would consider surgery, he insisted that Taiwo begin to wear polycarbonate glasses. Like his Kellogg colleagues, Dr. Kahana tells his patients they must protect their “good” eye with shatter-resistant lenses. Dr. Kahana then presented his plan: replace the ear-lier implant with tissue from Taiwo’s thigh to create the supporting structure. There are several techniques a sur-geon can use to reshape the orbit, and many nuances in performing the surgery, says Dr. Kahana. “The ultimate goal is to have good reconstruction that is long lasting and allows for a good prosthetic fit,” he says. “Orbital reconstruction can be easy to do but hard to do well.” After surgery, Dr. Kahana was pleased at last to see a smile on his patient’s face. “I think he finally could

see the light at the end of the tunnel,” says Dr. Kahana. Then Taiwo went on to see Gregory Dootz, Kellogg’s ocularist who has been creating and fitting prosthetic eyes for Kellogg patients for some 29 years. One of three surgeons on Kellogg’s Eye Plastic, Orbital and Facial Cosmetic Surgery service, Dr. Kahana credits his colleagues with having built a strong practice that serves as a major referral center for difficult eye plastic surgery. Then too, there is the fore-sight of recently retired ser-vice chief, Bartley R. Frueh, M.D., who came to the Department to start the Eye Plastic Service nearly thirty years ago. One of his early decisions was to hire Gregory Dootz, says Dr. Kahana. “Dr. Frueh was an accomplished surgeon who knew that to do orbital reconstruction well it was essential to have an expert ocularist on staff and then work together as a team.” Despite many doctor’s appointments and surgeries, Taiwo is very positive. His father offered strong encour-agement, and Taiwo, now 15 years of age, says, “It was easy except for the surgery. It’s all OK now.”

“Orbital reconstruction

can be easy to do but

hard to do well.”

— ALON KAHANA, M.D., PH.D.

Taiwo Bilesanmi at a follow-up visit with Dr. Kahana.


ON THE ROAD AGAINBig Ten eye doctors go to Vietnam

In March, five-year-old Vee, who lives in a small village outside Da Nang, Vietnam, had surgery to correct a tendency for his eyes to turn inward and upward. Vee’s surgeon was pediatric ophthalmologist Monte A. Del Monte, M.D., who had come to Vietnam with ORBIS, an organization that brings a Flying Eye Hospital and ophthalmologists to countries where eye care and mod-ern techniques are scarce. There was added commotion, as cameras followed Vee and Dr. Del Monte to film a televised special featur-ing ophthalmologists from Big Ten universities teaching local ophthalmologists and providing surgical treatment

in developing countries. Michigan was represented by Dr. Del Monte and alumnus Keith C. Carter, M.D., who completed his residency at Kellogg and today is chair of the Univer-sity of Iowa’s Department of Ophthalmology. By the end of the week, Dr. Del Monte had performed 15 surgeries on children and adults with

strabismus, a condition in which the eyes are not properly aligned. His young patient Vee had a form of strabismus called esotropia with overacting inferior oblique muscles, causing inward turning or crossing and vertical upshooting of his eyes, the most common con-dition Dr. Del Monte saw during his stay in Da Nang. At the heart of ORBIS is the goal of training local doctors, nurses, and other health workers in state-of-the-art ophthalmic diagnostic and surgical techniques. This is vital in a country like Vietnam where just 10 ophthalmologists are available per million people. Assisted by a local ophthalmologist during Vee’s surgery, Dr. Del Monte was able to demonstrate a new surgical technique, a stitchless self-closing incision underneath the eyelid in a way that eliminates external stitches. “It is very comfortable for the patient, but technically more difficult for the surgeon,” says

Dr. Del Monte. “But when we use this technique, we see kids opening their eyes and smiling immediately after surgery. They have less pain, and they can be outside playing the next day.” Sure enough, when Dr. Del Monte visited Vee in his home after the surgery, the young boy was doing just fine, playing with a friend. When not performing surgery, Dr. Del Monte lectured to ophthalmologists who had come from all over the country. Again stressing its educational mis-sion, ORBIS asks volunteer physicians to bring several educational lectures when they travel. Dr. Del Monte has participated in a number of international programs, but this one had special mean-ing for him. His son, Derek, who completed his medical training at Michigan and is now a first-year ophthal-mology resident at Duke University, accompanied him on the trip. “The experience sold him on the excitement and rewards of international ophthalmology, and in a few years I expect to see him pursue the ORBIS program for third-year residents.” “One of the greatest rewards is that the families are so grateful,” adds Dr. Del Monte. “You know how frightened the patients are before surgery, and then you see big smiles on their faces after they become aware of the results.” Dr. Del Monte was especially touched by a unique personal gift he received from several of his patients’ families: an intricately carved marble tray, dragon pitcher and matching cups, each engraved with the name of one of his surgical patients. Dr. Del Monte will be featured in a televised special to air this fall. Check our web site for details.

Training local doctors is

vital in a country like

Vietnam where just 10

ophthalmologists are

available per million

people.

Representatives from the Big Ten on the tarmack in Da Nang: Keith Carter, M.D., Derek Del Monte, M.D., Wanda Martinez, M.D., Monte Del Monte, M.D.,

and Hua Gao, M.D., Ph.D.

“You know how frightened the patients are before surgery,

and then you see big smiles on their faces after they

become aware of the results.”— Monte A. Del Monte, M.D.

Dr. Del Monte teaching local ophthalmologists in the O.R. Five-year-old Vee before his surgery. Vee and his parents after his surgery.

Hua Imperial Palace, Hua, Vietnam. Sanpan water taxi, Hoi An, Vietnam.

Dr. Carter examines a patient’s x-ray. Dr. Del Monte with his local trainees: Dr. Ngoc, Dr. Huang, and Dr. Tan.


Celebrating Philanthropy

By endowing professorships,

providing support for expansion,

and making annual gifts

to research, individuals and

foundations are helping the

Kellogg Eye Center reach new

levels of excellence.

Victor M. Elner, M.D., Ph.D.

CELEBRATING PhIlanthroPy 23

ENDOWING A LEGACYOphthalmic pathologist Dr. Victor Elner honored as Ravitz Foundation establishes a professorship that recognizes a little-known specialty

When Detroit native Edward Ravitz began a Foundation to help improve the health of his fellow citizens, he decided to support efforts that sought good over glory, says Burton R. Shifman, president of the Ravitz Foundation. Mr. Shifman and his fellow trustees fol-lowed that mission in establishing the Ravitz Foundation Professorship in Ophthalmology and Visual Sciences at the Kellogg Eye Center this year. Victor M. Elner, M.D., Ph.D., is the first to hold the professorship. His specialty of ophthalmic pathology is essential to treating and understanding eye disease, but it receives little notice. There are only ten ophthal-mic pathologists in the U.S., working to identify the correct source of disease. “In many ways, it’s a dying area of expertise, and I commend the Ravitz Foundation for recognizing its importance and working to ensure it continues to benefit patients,” Dr. Elner says. As an ophthalmologist and a pathologist, Dr. Elner examines eye tissue to draw connections between the underlying disease process and the most effective ap-proaches to diagnosis and treatment. He plays a central role in training new ophthalmologists. “His appoint-ment as Ravitz Professor will benefit both our Depart-ment and the entire field of ophthalmology,” says Paul R. Lichter, chair of the U-M Department of Ophthalmology and Visual Sciences. Dr. Elner has been on the Kellogg faculty since 1988. He received his medical degree, residency train-ing, and fellowship training in pathology from the University of Chicago and completed additional fel-lowships in pathology and ophthalmic plastic and reconstructive surgery. His research has shown that inflammation is often a cause of eye disease or its com-plications, and he has described the chain of events that results in the destruction of cells leading to vision loss. He also collaborated with Kellogg scientist Howard R. Petty, Ph.D., in developing a state-of-the-

art camera system that detects eye disease long before the first symptoms occur (see p. 7). Dr. Elner’s clinical specialties include the evalua tion and treatment of eyelid and orbital tumors, thyroid eye disease and disorders affecting the eyelid and tear ducts. He has published more than 150 articles on pathologic entities and advances in eye plastic surgery. Mr. Ravitz, a businessman who oversaw the building of more than 25,000 single-family homes and apart ments in Michigan and other states, would have ap preciated the steady, groundbreaking progress Dr. Elner has made. From his hardworking immigrant parents, Mr. Ravitz learned ethics and responsibility. He became a decorated combat army officer in World War II, after which he overcame many obstacles in building a company that ultimately grew to 600 indi-viduals. Though Mr. Ravitz passed away in 1999, his Foundation continues to pursue his vision of supporting medical research and initiatives that eliminate prejudice and further a sense of community and shared humanity. At U-M, gifts from the Ravitz Foundation have established a professorship in the U-M Department of Pediatrics and Communicable Diseases and the Ravitz Foundation Phase 1 / Translational Research Center at the U-M Comprehensive Cancer Center. The Founda-tion has also supported C.S. Mott Children’s Hospital, the U-M Depression Center, the Medical School, the School of Public Health, the Dental School, the Depart-ment of Molecular and Integrative Physiology, and the Division of Kinesiology.

Taking time to celebrate: Ravitz Foundation board members Lawrence F. Handler, M.D., Bruce D. Gelbaugh, Burton R. Shifman, and Arnold J. Shifman with Kellogg’s

Paul R. Lichter, M.D., (center left) and Victor M. Elner, M.D., Ph.D. (center right).


A NEW ERA OF PEDIATRIC EYE CARE The Carls Foundation Pediatric Ophthalmol-ogy Clinic will have more space, resources to help children battle eye disease and trauma

Children with vision problems come from throughout Michigan and around the world to see pediatric oph-thalmologists at the Kellogg Eye Center. Those physi-cians will be able to care for even more young patients when the addition, which will house the new Carls Foundation Pediatric Ophthalmology Clinic, opens in

the spring of 2010. “We are nearly dou-bling the space we devote to children’s eye care and to pediatric vision research and training programs,” says Monte A. Del Monte, M.D., Skillman Professor of Pediatric Ophthalmology and a Professor of Pedi-atrics and Communicable Diseases. The Carls Foundation,

based in Detroit, is proud to be a part of the effort. The Foundation has pledged $2 million to support the expansion and sees the mission of the pediatric ophthal-mology clinic as very close to its own, says Executive Director Elizabeth A. Stieg. “One of our main goals is to help make children’s lives better, and we understand how important it is to correct a child’s vision problems as early as possible.” The new 4,000-square-foot clinic will be on the first floor of the Kellogg addition and will include 10 examination rooms, each with the required 22-foot examination lane needed to accurately measure a child’s eye alignment. The clinic will also be equipped with advanced diagnostic technology as well as a special

procedures room, a clinical trials and digital imaging room, and a multi-media patient education room where families can learn more about eye diseases. The new space will enable Kellogg to recruit two additional academic pediatric ophthalmologists who will see patients and conduct research. Kellogg faculty members today study conditions such as childhood glaucoma, retinopathy of prematurity, intraocular lens placement in children, thyroid-associated eye disease and strabismus, and many other vision diseases that affect children. Scientific breakthroughs were important to Detroit industrialist William Carls, who started the Foundation in 1961 with his wife, Marie Carls. They had lost a child in infancy and became interested in helping chil-dren receive the best possible medical care, Ms. Stieg says. Mr. Carls took an active role in directing the grants of the Foundation until his death in 1995. “He was a wonderful man, and he enjoyed seeing what resources matched with expertise could accom-plish in a community,” says Ms. Stieg. “He liked to see things happen.” An engineer by training, Mr. Carls was particularly interested in building projects and technology, she says. The Carls Foundation today sup-ports pediatric health facilities and programs throughout the state, as well as youth activity programs and the preservation of natural areas and historic buildings. At the University of Michigan, the Carls Foun-dation has also supported the Mott Children’s Hospital construction, a diagnostic and treatment program for children at risk for profound hearing loss, and research in the area of jaw-related birth defects.

“We are nearly doubling

the space we devote to

children’s eye care and to

pediatric vision research

and training programs.”

— MONTE A. DEL MONTE, M.D.

William Carls


THE EYE CENTER ExPANSIONMAKES RAPID PROGRESSNew building will help us improve the lives of our patients and achieve new levels of excellence in research and education

On a blustery November day, friends, faculty, alumni, and staff gathered to celebrate another milestone in the Kellogg Eye Center expansion. The “Topping Out” ceremony marks completion of the major structural steel in a construction project, and the safety of the crew who worked on it. The traditional signing of the last beam took place during the morning and, later in the day, the Kellogg community gathered to watch and cheer as the beam was hoisted to the top of the building. Since that day work has continued with great speed. As the internal structure of this adjoining build-ing takes shape, we can begin to see just how much space we will gain. The 8-story building will provide 230,000 square feet of additional space, allowing each of Kellogg’s seven clinics to expand patient care, as well as offer patients larger and more comfortable waiting areas. The facility will also include new surgi-cal suites, new and innovative research space, and a unique diabetes research center: the Delores S. and William K. Brehm Center for Type 1 Diabetes Research and Analysis. This substantial increase in space means that we can recruit new faculty who, together with current faculty, will make the Department a formidable force in ophthalmology and the visual sciences. The educa-tional benefits for our fellows, residents, and vision scientists will be immeasurable. The Eye Center will serve many more patients, and will be known as a des-tination for those seeking the most advanced care avail-able. New research laboratories will accelerate progress toward treatments for debilitating eye disease. “Our essential mission is clear,” says Department Chair Paul R. Lichter, M.D. “We will discover treat-ments and cures to improve the lives of our patients. With growth and new resources, and the dedicated support from friends, we can offer hope to patients and their families that cures for eye disease and blindness are just ahead.”

The view looking south from Broadway.

The view from the park in back of the building.

Helmut Stern, Larry Miller, Carolyn Lichter, Marian Poling, Harold “Red” Poling, Paul Lichter, M.D., Doug Strong, and Perry Schechtman gather just before the

Topping Out ceremony.


$2 million and upCarls FoundationEdwin E. and Mary U. MeaderLarry G. Miller

$1,000,000 to $1,999,999Lynn H. and Robert W. Browne, D.D.S.Richard and Jane Manoogian FoundationHarold A. and Marian L. PolingHelmut SternRobert and Ellen ThompsonThe Harry A. and Margaret D. Towsley Foundation

$500,000 to $999,999John F. and Casilda Daly

$250,000 to $499,999Mickey and Karen ShapiroTimothy and Laurie G. Wadhams

$100,000 to $249,999Anonymous DonorFrank J. and Helga ArnoldCharles and Rita GelmanJohnson Controls FoundationCarolyn and Paul LichterKeith and Della McKenzieDr. Charles L. and Kathleen K. SmithDavid and Jayne VerLeeMary June and William Wilkinson

$50,000 to $99,999Steven and Constance BenzAnne and Terry J. BergstromDave and Yvette BingThomas C. Brown

James and Martha ConradWilliam and Carol CutlerGloria P. and William E. Dean, Jr.Ruth B. DixonRobert and Cassandra EstesDouglas P. and Shelley FeltVincent R. and Joyce McLeanJames and Nancy RavinRennie and Michael RothAlan and Gail Sugar

$25,000 to $49,999Anonymous Donor ~ 2James and Kathryn AdamsHerbert and Carol AmsterHarry and Patricia BashJoe and Beth FitzsimmonsrichardandlisagarfinkelLarry and Mary GerbensJames T. and Charlene L. Glerum Orpha IrwinHelen and Richard KerrKim Lindenmuth and Matthew BuecheRoger Meyer and Judy GordonJohn and Phyllis NapleyMichael Petersen and Elizabeth BinasioHelen and Earl Schaper

$10,000 to $24,999Alfred Berkowitz FoundationSeth BonderGeorge and Connie CressDow Chemical Company FoundationAnn and Joseph W. EdwardsRobert G. Fante, M.D.David GavrinHarry C. Gibson, M.D.E. Paul and Lillian Gieser

Richard F. GutowJohn R. HeckenlivelyVirginia HickmanRobert and Joan HughesKALSEC CorporationW.R. KenleyRobert and Mary KiessJames G. and Carolyn KnaggsCarol L. Makielski and Charles D. LakeDonald and Jacqueline McCullochDean and Lynn MitchellAndrew and Cathryn MoyesStanley and June OleksyU.E. PatrickSally J. PryceJames R. QuinnMichael and Debra RaizmanJames D. and Helene C. ReaderFranklin and Marilyn SassamanPerry and Faith SchechtmanMichael and Linda Smith-WheelockSusan and David ThomsAlfred and Carol WickW. Scott and Jill Wilkinson

$5,000 to $9,999Everton and Saundrett ArrindellNancy BenderDonald and Christine BeserRobert D. and Jennie P. Biggs Garry and Gretchen BinegarFred and Miriam BlumRalph and Kay CrewAndrew and Margaret HanzlikDr. and Mrs. John W. HendersonPeter and Karla HitchcockMark and Linda JohnsonMetaldyneNew England Eye CenterVenkat and Alvira ReddyH. Kaz Soong and Barbara Nevins-SoongDanny D. Wang and Yili Wang

$1,000 to $4,999Steven and Carol ArcherJames and Martha BarnettEdward and Martha BoggsWilliam and Julie Bromley

kellogg eye center expansion honor roll We thank the following individuals for making gifts and multi-year pledges in support of the construction of the new Kellogg Eye Center building.


Bruce CameronBill and Janet CassebaumMark and Judith CohenBarb and Wayne CornblathDeborah M. CoxMonte A. and Kristen G. Del MonteGayle D. DickersonThomas and Susan EssmanFrancis FalckJudith FitzGerald and Robert GlinertPhilip Gage and Wendy Rampson-Gage Dasa and Nalini GangadharCarol and Edward GeorgeJon and Sarah GieserRobert GoldsmithDaniel and Norma GreenRobert O. and Carolyn S. HoffmanBret and Laura HughesDavid and Patricia JohnsonRobert KeilKey FoundationKirk and Constance LignellBernard L. Maas FoundationJames Albert MaraldoMarvin Joe and Beverly McKenneyShahzad Mian and Uzma AhmadSayoko Moroi and Mike FettersChristine Nelson and Willis LillardBetsy and Ken NisbetMohammad and J. Elizabeth OthmanMark and Kimberly PhelanSheryl and Douglas PodlewskiDonald and Debra PuroJulia Richards and Carl MarrsGary and Diana SandallMarcia and David SchmidtTara Schmitt and Christopher PalumboCarol and Irving SmoklerCarol L. StandardiRichard and Joyce TonerPeter and Adele VaculikMargaret VezinaRichard L. WacksmanRandall S. and William K. WallachRichard and Kay WatnickAdrienne West and Mark Hemmila

$500 to $999William and Elizabeth ArendshorstEric ArnoldFrederick and Jean BirkhillSteven and Jacqueline BoskovichChristina BrunoMargaretAnn Cross and James Van Fleteren Carolyn and David DilesGregory and Dottie DootzJerome and Polly FinkelsteinMartin and Elaine GoodeJune and R. James HarveyWilliam HawkinsReid and Donna JohnsonRichard Alan and Patricia N. LewisRichard Rodman and Patrice Bouzan-RodmanStephen and Kim SaxeWarren and Nancy SchererBarney and Geraldine SchwartzAtta Rae and Gabriel SitrinE.H. Newel and Rosemary SmithThomas and Jane StratfordScott E. SzalayDebra Thompson and William StrongJames B. ThompsonJeanne K. WaltersRonald E. Warwar, M.D.Margaret B. WhiteBeverly Yashar and John MesbergDavid Zacks and Susan Harris

up to $499Cynthia AbejuroKatherine AugustaitisMike BergielSamir and Mona BinnoRenee BlosserCarolyn and Leonard BohmMarcia J. BoyntonLisa Burkhart and Frank HuntJames W. and Nola CavettBeverly A. ConkleMarlene and Paul DodgeDonna M. DuffyHal and Donna EstryDarlene C. Fero

Elena FilippovaJacqueline A. ForrestBruce and Susan FurrChad and Courtney GodfreyDr. and Mrs. Edward F. HallTheodore and Naomi HarrisonMargaret HartzJoseph and Lori HymesWalter IngramRobert and Joan JampelLaura E. Kakuk-AtkinsAthanasios J. KaroukisAdabelle KniefJudith KnitterPiyush and Sarla KotharySusan L. LichterMichael and Judy LipsonSusan LudwigSteven ManikasJames and Gay McGuckinMidwest Transmission, Inc.Donald and Barbara MitrzykVictor and Kendra MonroeDavid and Benita MurrelDr. Dave and Jan MuschAjay Natarajan and Ritu KhannaOlga NelsonGale and Yehuda OrenHemant PawarRebecca and Paul PazkowskiCarol J. Pollack-Rundle and FamilyFrank Rozsa and Szonja Puskas-RozsaRoss and Shannan SaltzCindy ShaffranSusan and Gary SimpsonCamille S. SmithJeanne F. SmithBecky and Doug SpalyAmy SteeleNorma and Gene StohlerAnand and Manju SwaroopPat and John TongusiJonathan Trobe and Joan LowensteinMolly and Robert WheatonAlyce WhippKim WisniewskiAnthony WojciechowskiJennifer Ziehm-Scott


A NEW IMAGE Photography faculty and staff look forward to the creation of the Harry A. and Margaret D. Towsley Ophthalmic Imaging Center With more than 70 years of combined experience in medical photography, the faculty and staff of the Harry A. and Margaret D. Towsley Ophthalmic Imaging Center are preparing to make the most of their new space when the addition to the Kellogg Eye Center opens in 2010. The Harry A. and Margaret D. Towsley Foundation has agreed to make a $1.5 million grant to the Kellogg Eye Center expansion campaign and will name the ophthalmic imaging center. The gift builds on the Towsley family’s longtime support of vision care at the University of Michigan. “It is a family tradition to be involved with the Kellogg Eye Center, but more importantly we are thrilled and excited about the work they are doing today,” says Margaret Ann Riecker, Chairperson of the Foundation and one of Harry and Margaret Towsley’s daughters. The center will be completely digital, allowing photos to be a central part of Kellogg’s new electronic medical record. It will feature individual procedure rooms for patients and will be located on the second floor near the retina and glaucoma clinics, two subspe-cialties that use photography services the most. “The new space will be better for patients because of its proximity to the clinics, and it will encourage more communication between physicians and our staff,” says ophthalmic photographer Linda Goings. Ophthalmic photographers at Kellogg are involved in patient care as well as research. They use special equipment to take photos of the retina, cornea, and other parts of the interior of the eye as well as perform dye- and laser-based testing. Images of the eye are

important to diagnosing and treating disease, as well as for research and teaching purposes. Kellogg photog-raphers have also worked with Drs. Howard R. Petty and Victor M. Elner to develop a camera that can detect eye disease in its earliest stages. “Our new space will be conducive to those kinds of projects, and we are looking forward to doing more research,” says Richard E. Hackel, Director of Ophthal-mic Photography and assistant professor in the U-M School of Art. Supporting medical progress is a priority of the Towsley Foundation. “The whole idea of good science and research is so important to health care, and the University of Michigan is certainly the place for that,” says Mrs. Riecker. Both Harry and Margaret Towsley were graduates of U-M. Harry Towsley, M.D., served the U-M as pro-fessor of pediatrics and chairman of the post-graduate medicine department. The Towsley Foundation’s wide-ranging support at U-M has included leadership gifts toward the construction of the Charles R. Walgreen, Jr. Drama Center and the Athletic Department’s Stephen M. Ross Academic Center, as well as to the Harry A. and Margaret Towsley Policymaker in Residence pro-gram in the Gerald R. Ford School of Public Policy.

The Ophthalmic Photography staff who will occupy the new Towsley Imaging Center: Robert Prusak, Richard Rice, Richard Hackel (Director), and Linda Goings.


ANNUAL GIVING PROPELS VISION RESEARCH FORWARDFralick Society recognizes donors who partner with Kellogg

Discovering how the brain processes visual informa-tion, how zebrafish repair their own retinas, and what takes place when cells essential to sight begin dying — these are all areas of research that were supported by contributions to the Kellogg Eye Center’s annual funds this year. The Annual Fund and the Alumni and Faculty Annual Fund are the cornerstones of the philanthropic giving that helps Kellogg fulfill its mission. As unre-stricted research funds, they support the most innova-tive and promising studies, sustain strong research programs between grants, and provide extra resources to projects in key stages of discovery. To recognize and celebrate annual gifts to research of $100 or more, Kellogg has created the F. Bruce Fralick Society. Named in honor of the Department’s fifth chair, the Society sponsors an annual luncheon where Chair Paul R. Lichter, M.D., and other faculty members share news of scientific advancements. The forum provides an opportunity for donors to interact with scientists and to meet one another. Members who support Kellogg’s programs at the Benefactor level ($1,000 or more) or above are also invited to special tours of our research laboratories. More than 600 individuals are members of the Fralick Society, including many alumni.

Fralick ProfessorPaul R. Lichter, M.D.,Receives TopOphthalmologyAward

Paul R. Lichter, M.D., received the Lucien Howe Medal from the American Ophthalmological Society (AOS) for his distinguished

service to ophthalmology. The Howe Medal, first awarded in 1922, is one of the highest honors in the field of ophthalmology. Dr. Lichter is Chair and F. Bruce Fralick Professor of the U-M Department of Ophthalmology and Visual Sciences. He is also Director of the W.K. Kellogg Eye Center. Recipients of the Howe Medal are “individuals who have made powerful marks on our ophthalmic heritage,” said Dennis J. Robertson, M.D., Profes-sor Emeritus of Ophthalmology at the Mayo Medical School, who presented the award on behalf of the AOS. He cited Dr. Lichter’s service to professional organi-zations, his pivotal role in clinical studies involving patients with glaucoma, and his research on the genet-ics of glaucoma. “His leadership and tenacity helped spearhead a number of studies, including one that was uniquely dear to his heart, involving quality-of-life issues among glaucoma patients,” said Dr. Robertson. Dr. Lichter’s leadership and vision have left their mark on every important ophthalmological organiza-tion, beginning with the American Academy of Oph-thalmology (AAO), which he served as President during its centennial year. However, his influence on policies was also felt in other organizations where he was president, from the Association of University Professors of Ophthalmology to the Pan American Association of Ophthalmology. Dr. Lichter was recognized for having authored over 200 publications and for giving numerous named lectures. He served as Editor-in-Chief of the AAO’s journal, Ophthalmology, and on editorial boards of several major journals. Dr. Robertson noted that Dr. Lichter wrote many “thought-provoking editorials” and was never afraid to take on a controversial issue.

Chairman F. Bruce Fralick, M.D., broadened the mission of the Department to include investigations into the basic science of sight.


annual honor roll of DonorsWith heartfelt thanks to donors who

made gifts from July 1, 2007, to June

30, 2008. Included in this listing are

contributors whose donations are part

of multi-year pledges.

$500,000 to $999,999The Foundation Fighting BlindnessThe Ravitz Foundation

$100,000 to $499,999Edward T. and Ellen K. Dryer Charitable FoundationInternational Retinal Research FoundationRichard and Jane Manoogian FoundationLarry G. MillerHarold A. and Marian L. PolingElmer and Sylvia Sramek Charitable Foundation

$50,000 to $99,999Brian P. and Mary Lincoln CampbellGloria P. and William E. Dean, Jr.Michael A. Wainstock, M.D.Mary June Wilkinson

$10,000 to $49,999Anonymous donorNancy BenderAdena D. ButlerJean E. CraigAnn and Joseph W. EdwardsRita Jane Edwards EstateRobert and Cassandra EstesDouglas P. and Shelley FeltElaine FrickBartley and Cheryl FruehMuhieddine Ghandour and Hala JaroudiJames T. and Charlene L. GlerumRichard F. GutowVelma E. HarnessIntralase CorporationW.R. KenleyRaul Philip MartinezKeith and Della McKenzieVincent R. and Joyce McLeanJoel and Susan MindelNational Glaucoma ResearchSally J. PryceJames and Nancy RavinRoberta W. SiegelVirginia L. SivacekMildred E. Swanson FoundationHelen M. Taylor

Betty and Stanley J. ThomsonTimothy and Laurie G. Wadhams

$5,000 to $9,999Anonymous donorHarry and Patricia BashFrank and Barbara BatschMichael and Joanne BissonScott M. Corin and Nina BlumenthalFairfieldcorporationEmeline N. FallsrichardandlisagarfinkelFrances and David H. GrossmanGary GutowJohn R. HeckenlivelyPege Harvey-MatthewsBarry and Mary Ann HoffmanHelen and Richard KerrJames G. and Carolyn KnaggsMichael Petersen and Elizabeth BinasioMarian A. and Edwin C. Schilling, Jr.Barbara and Anthony StoneAlan and Gail Sugar

$1,000 to $4,999James and Kathryn AdamsAnn Arbor Area Community FoundationSteven and Carol ArcherEverton and Saundrett ArrindellAnne and Terry J. BergstromRobert D. and Jennie P. BiggsGarry N. Binegar, M.D.Fred and Miriam BlumHenry A. Boldt, Jr., M.D.Thomas W. BreakeyJason M. Burgett, M.D.Keith D. and Cheryl D. CarterJanet and Bill CassebaumMark and Janet CichowskiMark and Judith CohenWilliam and Carol CutlerMonte A. and Kristen G. Del MonteJ. McGregor and Christine DoddsFrances DupontFrederick E. Dupont, Jr.Robert G. Fante, M.D.Fight for SightMargaret E. GallupLarry and Mary GerbensE. Paul and Lillian GieserJoanne R. GradowskiRobert and Teresa GrosserodeKenneth Alan HallerWilliam P. Haney, M.D.Robert O. and Carolyn S. HoffmanKathy and Jim HolmesBret and Laura Hughes

couple Makes research a Priority

Hope and empowerment are behind the enthusiasm with which Jim and Kathy Holmes support vision research. “Giving is a way for us to do something active to fight eye disease, and because such wonderful research is being done, we are able to hope for the future,” says Mrs. Holmes. She and her son have retinitis pig-mentosa, an inherited disease that causes the degeneration of light-sensing rod and cone cells. While she has vision difficulties associated with the condition, she believes the progress being made will help her son. Mrs. Holmes began coming to the Kellogg Eye Center in her mid-20s. “Kellogg has been a blessing,” she says. Mr. and Mrs. Holmes make annual gifts to the laboratory of David N. Zacks, M.D., Ph.D., a clinician–scientist who studies the biological chain of events that results in the death of rod and cone cells. “As Jim and I were able to make gifts, we decided to set priorities, and eye research was at the top of the list,” says Mrs. Holmes. “Vision is a gift. We would like to see more treatments and cures, and we want to do what we can toward that goal.”

The Holmes family: Kristin, Jay, Kathy, and Jim


Walter and Barbara HungerfordMrs. Virjean JohnsonJeffrey A. KahnKeith and Susan KobetCarolyn and Paul LichterWilliam W. LoveDr. Marvin and Sue LubeckJames Albert MaraldoJean Beyst-Martonyi and Csaba L. MartonyiDonald and Jacqueline McCullochMarvin Joe and Beverly McKenneyCorey A. Miller, M.D., and Nancy J. MillerDean and Lynn MitchellKenneth H. Musson and Patricia MussonBruce L. and Roberta OliverP & G FundMichael and Karen PachtmanMark and Kimberly PhelanScott M. Pinter, M.D.Venkat and Alvira ReddyGary S. SandallFranklin and Marilyn SassamanPerry and Faith SchechtmanMarcia and David SchmidtDonald H. SchriverAlan and Sandra SchwartzAlene M. SmithCharles and Kathleen SmithMichael and Linda Smith-WheelockH. Kaz Soong and Barbara Nevins-SoongPeter K. SpeertTriford FoundationGerald M. TrocchioDavid and Jayne VerLeeAndrew Vine and Caroline BlaneGenevieve E. WalinskiHerbert E. WestonGeorge C. WhitakerMarina V.N. and Robert F. WhitmanW. Scott and Jill Wilkinson

$500 to $999Gerald and Gloria AbramsRoger D. ArnettEdward and Martha BoggsJames and Jacqueline BowenWilliam and Julie BromleyChristine R. BuseRuth F. ClarkeTheresa M. Cooney, M.D.Deborah M. CoxMorton S. Coxdamon’sgrillRoland and Louise W. DeMartinGayle D. Dickerson

M. Kenneth and Arvene DicksteinDow Chemical Company FoundationJohn S. DunnMagdalen Skuba EdwardsShawn F. FaganJohn N. FettersRalph M. FoxPhilip Gage and Wendy Rampson-GageDasa and Nalini GangadharHarry C. Gibson, M.D.Waleed K. GosaynieHenry E. and Kathryn G. GrayAdele GudesFroncie GutmanTheodore and Naomi HarrisonJune and R. James HarveyDr. and Mrs. John W. HendersonGerald W. HepplerJoyce D. HerronJames A. JohnsonMark and Linda JohnsonMaureen S. KennellyRichard and Lucille KingC. Byron Landis, M.D.Jean E. LewisRichard Alan Lewis and Patricia N. LewisHarry and Eva McGeeMary Ann and P. Anthony MezaElaine J. MickelsonBetsy and Ken NisbetPatrick J. and Bonnie K. PardenElizabeth M. Potter EstateAnn M. ReedJohn Wallace RiskPaul RizzoRobert Roosenberg, M.D.Charles ShermanCarol L. StandardiRichard and Joyce TonerMyrna TumanengJames F. VanderRichard L. WacksmanRonald E. Warwar, M.D.Marion T. Wirick

$100 to $499Ann T. AlexanderJ. Gregg and Dorothy E. ArbaughCharles R. AshcraftCharles and Nancy BagnascoDeane and Marilyn BakerI. Josephine BallertLawrence A. BarnesJames and Martha BarnettPhilip Barrons

alum Is Proud to support growth

When Larry J. Gerbens, M.D., finished his ophthalmology residency at the University of Michigan in 1978, the program was well respected but small. To watch it evolve into one of the top residency programs in the country has been exciting, he says. “I’m very proud of what I have seen happen.” The generosity of Dr. Gerbens and his wife, Mary, has helped support the Department’s growth over the years. They contributed to the initial building campaign for the Kellogg Eye Center in the early 1980s, and they made a gift to the current expansion effort. They also contribute to the Alumni Annual Fund for research, which Dr. Gerbens co-chaired this year, and they have included the Kellogg Eye Center in their estate plans. Dr. Gerbens is also a member of the Alumni Advisory Board. “Philanthropy has always been very important to us,” he says. “There’s a real joy that comes from giving.” Dr. Gerbens is grateful for his train-ing, which enabled him to earn a good living and help so many of his patients, he says. He practiced general and pediatric ophthalmology for years in Grand Rapids before retiring this past spring. “This institution gave me the chance to become an ophthalmologist, to enjoy the success that brings, and to develop a skill that I could use to help others,” he says. “It provided many opportunities for me and for my family.”


Donald F. Baty, Jr.James C. BeachumRoy W. BeckLois BerezaDr. and Mrs. W.G. BergenRhoda L. and Roger M. BerkowitzThomas A. Bersani and Joan ChristyMary Lee BeuerleMike Bishel and Clarita Guerrero-Bishel Myrtle B. BonemStephen Boorstein, M.D.Nancy S. BoutellDaniel L. BradenCarl A. Brauer, Jr.Betty Jean BrownJeremy and Barbara BrownMargaret C. BrownWilbur and Carolyn BurkettIrving F. BurtonDonald V. CalamiaCarola CaroselliJames W. CavettWilliam and Marilyn ChandlerAnne M. ChaseLillian V. ChoateJoan M. ChristyHideki and Tomomi ChumanMarilyn L. CitronShirley CoeBeck and David BeckDonald L. ColeClare R. ColesCarl and Maria ConstantPatrick J. CoppensEllen L. CoulthardMargaretAnn Cross and James Van FleterenSpeers M. CrumrineLyubica DabichJames E. DaviesWilliam and Virginia DawsonDelta Gamma Fraternity Ann ArborJames R. DevineHelen DeWolfeNorma DiamondMarlene and Paul DodgeDonald A. DodickRichard and Patricia DonaheyGregory and Dottie DootzMr. and Mrs. Kenneth R. DornbrookDonna M. DuffyCathlynn Duncan and George WatsonMrs. Lois A. DyerMs. Alice EngibousBita Esmaeli-Gutstein, M.D.Hal and Donna EstryBlaine and Jean Evans

Barbara FazioMrs. M. J. FeenerBryn A. and Suzanne M. FickCarol and Paul FinchJerome and Polly FinkelsteinDennis and Christine FornalJacqueline A. ForrestStephen and Rosamund ForrestRalph N. FunkCharles A. GallupPatricia M. GardnerSunir J. Garg, M.D.General Motors FoundationCarol and Edward GeorgeDavid and Sylvia GoodAnitra and Jesse GordonStar GuestBesondy and Margaret HagenJane HakkenCharlotte HansonHugh and Janet HarnessLaurelynne D. HarrisMichael and Carolyn HarrisHelen F. HatchRuth Heyn, M.D.Frederick J. HeynerMilton and Geraldine HiggsCarolyn and Larry HissRichard and Jane HissCharles F. HoitashJanet Woods HooblerJohn and Barbara HoshawHsin-Hong HuangChristy Bole HughesBernice E. HyneIllinois Tool Works FoundationJohnson Controls FoundationMr. and Mrs. Kenneth B. JohnsonS. Preston and Betty B. JonesGeorge H. JuryDaniel and Rose KachnowskiJill Taft KaufmanRobert B. Kaufman, M.D.Rosemary S. KayeKellogg’scorporatecitizenshipFundMichael A. Kipp, M.D.Robert and Toby KleinbergWilliam L. and Betty G. KnappJ. David KotreMrs. Harry KrashenTommy KromerGerald and Dorothy KurtzMarie LaneLouis and Gail LaRicheGloria A. LehmanJeanne M. Lerchen

Danute Leveckis and Timothy VanEveryBobbie and Myron LevineRobertson A. LewisSusan L. LichterKim Lindenmuth and Matthew BuecheThomas J. LongDr. A. Letitia LovelessHelen Price LuckhamRaymond W. LumleyAngelo MaesoSteven ManikasEdna F. MannsTerrence and Joyce McCoolDonna Rita McNallyDonald and Diane MeitzProfessor George E. MendenhallCarolyn E. MesaraRobert and Margery MeslerHerbert R. MetzgerMary L. MeyerWilliam M. MichalukHelen MitchellMs. Marlene M. MoleskiSayoko Moroi and Mike FettersJock MorrisonRichard G. MostellerDr. and Mrs. Joseph MottilloDr. Patrick J. and Mrs. Jacquelyn P. MulrowWilliam J. MundusDr. Dave and Jan MuschDr. Michel and Alice NasifChristine Nelson and Willis LillardJonathon P. NiemczakEdward NishonKenneth E. OettleCharles I. OjieloPaul L. OlsonGale and Yehuda OrenJohn OrrMohammad and J. Elizabeth OthmanKaren L. PacerMr. and Mrs. Edmund L. PalmerHarriet Parsons and John BrundageCarol M. PaullJoseph F. PavkaGordon E. Peckham, Sr.Sheryl and Douglas PodlewskiCarol J. Pollack-Rundle and FamilyRebecca and Eric PriebeDonald and Debra PuroDrs. Douglas J. and Leslie E. QuintWilliamM.redfieldMr. and Mrs. Walter F. RedmondRobert and Alice ReisigCharles S. Remenar


Rita and Robert ReskeThomas R. RiggsMr. and Mrs. Arthur C. RoccoHorace and Yvonne RodgersCarl D. RoeLucille and Harold RoperK.J. and P.J. RoperRose Metal RecyclingBeverly L. RosenthalRennie and Michael RothJonathan A. Rowe, M.D., and Robin L. RoweJim and Joan RuckerMajed and Rheame SahouriLoretta D. SammetStephen and Kim SaxeJohn and Dorothy SchaeferHelen and Earl SchaperLarry and Barbara SchererLeonard T. SchmidtEileen SchottJohn and Karen SchultzRuth I. SeguraDavid and Elvera ShappirioMrs. Lorraine M. SheppardPaul and Pam SievingPauline SkinnerSlauson Middle School PTSOE.H. Newel and Rosemary SmithJeanne F. SmithKenneth S. SmithSue-Ellen SmithBecky and Doug SpalyWalter and Nesta SpinkMr. and Mrs. John StrandThomas and Jane StratfordJoel Sugar and Anita GerberJames P. and Dorothy SymonsScott E. SzalayF. Brian TalbotJohn and Joan TedfordDewey TennentEdward and Karen TennerRoger C. ThibaultKaren and Michael ThomasJames B. ThompsonEdward ThornhillA. Richard TischlerPat and John TongusiMargaret J. TuomariNelly S. UllmanFrank VeresClaudia M. WagnerDavid R. WagnerA. Phyllis WallaceSidney Warschausky and Lorraine Nadelman

Joyce Muriel WeberLee S. WebsterCarol and Jack WeigelCarolyn Jean WeigleDr. and Mrs. William W. WellsSue and Kenneth Wenrich-BucholzAvis L. WhiteDr. Patrick T. and Mary WhiteE. Suzanne and Keith WilliamsJean A. and Richard C. WilsonJeneane WiseFord L. WrightMichael and Kathleen YangDr. Wen-Jei YangHarry and Miriam YukelsonHenry and Dorothy ZelisseJennifer Ziehm-ScottJeff and Kate ZinkThomas and Delle ZurSchmiede

In Memory Of

The Kellogg Eye Center is honored

to have received gifts in memory

of the following individuals.

James Daniel BenoreFred ChurchPatrick Mathew Davis IIIFred E. DupontJane G. ElliottSylvia GoodePailoon JevaharianDr. KemmickMarjorie McDonaldEdward W. MeyerCharles F. Moore, Sr.Madeline PellerinEileen PeraultHarold A. RoperMadeline L. VantineDorothy Jane WilliamsBetty Yendall

In Honor Of

The following individuals were

honored through gifts to the

Kellogg Eye Center.

Monte A. Del Monte, M.D.Ernest and Linda DunnJerome I. Finkelstein, M.D., FACSF. Bruce Fralick, M.D.Martin Goode, D.D.S.John R. Heckenlively, M.D.Walter HungerfordIda L. Iacobucci, C.O.Paul R. Lichter, M.D., FACS

Shahzad I. Mian, M.D.Sayoko E. Moroi, M.D., Ph.D.Stephen J. Saxe, M.D., FACSK. P. Sogoian Manufacturing and its employeesGabriella StoneSusan S. Thoms, M.D.Andrew K. Vine, M.D.David N. Zacks, M.D., Ph.D.

Bequests and Other Planned Gifts

It is with deep gratitude that we

recognize the following individuals

for making the Kellogg Eye Center a

part of their estate plans.

Frank J. and Helga Arnold Nancy Bender Anne S. BenninghoffRhoda L. and Roger M. BerkowitzRobert D. Biggs, M.D. Ruth F. ClarkeGloria P. and William E. Dean, Jr. Ralph M. Fox Helen A. (Poorbaugh) Freedman Larry and Mary GerbensEd and Sue GorneyIda Lucy Iacobucci Mrs. Harry KrashenHarry and Eva McGee Marvin Joe and Beverly McKenneyBruce L. and Roberta OliverMrs. Shirley M. SchaibleWilliam Selezinka, M.D.E.H. Newel and Rosemary SmithRussell A. Stephens and Phyllis A. Capogna David and Jayne VerLeeMichael A. Wainstock, M.D. Jean A. and Richard C. Wilson

Only those who gave their permission

are included above. If you have a be-

quest and were not contacted, please

call us at 734-615-0243.

Special Thanks

With appreciation to Myron Hepner

and Delta Gamma Fraternity for

their volunteer fundraising activities.

We make every effort to ensure

the honor roll is as accurate as

possible. Please let us know if

you note any errors.


Steven M. Archer, M.D.

Awards/Honors/Leadership•Best doctors in America•ElectiontotheSquintclub

PublicationsWolf AB, Yang MB, Archer SM. Postoperative myositis in reoperated extraocular muscles. J AAPoS 2007;11:373-6.

Eibschitz-Tsimhoni M, Archer SM, Del Monte MA. Intraocular lens power calculation in children. Surv ophthalmol 2007;52:474-82.

Garg SJ, Archer SM. Consecutive cyclic exotropia after surgery for adult-onset cyclic esotropia. J AAPoS 2007;11:412-3.

Eibschitz-Tsimhoni M, Archer SM, Furr BA, Del Monte MA . Current concepts in the man-agement of concomitant exodeviations. comp ophthalmol update 2007;8:213-23.

Peters ER, Archer SM. Long-standing, large-angle exotropia in adults. Am orthoptic J 2007;57:104-6.

Archer SM. Monocular diplopia due to spherocylindrical refractive errors. Trans Am ophthalmol Soc 2007;105:252-71.

Eibschitz-Tsimhoni M, Archer SM, Del Monte MA. Effect of axial length and keratometry measurement error on intraocular lens im-plant power prediction formulas in pediatric patients. J AAPoS 2008;12:173-6.

Trzcinka A, Moroi S, Soans FP, Archer SM. Late-onset Haemophilus influenzae endo-phthalmitis in an immunized child following Baerveldt implant. J AAPoS 2008 [in press].

Radha Ayyagari, Ph.D.

Grantssee grants, page 44

Awards/Honors/Leadership•ScientificadvisoryBoardMember, Foundation Fighting Blindness•reviewer,FoundationFightingBlindness•Member,Steeringcommittee,national Ophthalmic Diagnostic Genotyping Network (eyeGENE), National Eye Institute, NIH

PublicationsReddy GBB, Satyanarayana A, Balakrishna N, Ayyagari R, Padma M, Viswanath K, Pe-trash JM. Erythrocyte aldose reductase activ-ity and sorbitol levels in diabetic retinopathy. Mol Vision 2008;14:593-601.

Yzer S, Zonneveld M, Lopez I, Ayyagari R, Teye-Botchway L, van den Born LI, Mota-Vieira L, Cremers FPM, Koenekoop RK. Phe-notypic and molecular analysis of a family with three sibs affected by severe autosomal recessive retinitis pigmentosa and a second cousin affected by Stargardt macular dystro-phy. Mol Vision 2007;13:1568-72.

Roberts DK, Ayyagari R, Moroi SE. Possible association between long anterior lens zonulesandplateauirisconfiguration. J glaucoma 2008 (in press).

Grant M. Comer, M.D.

Awards/Honors/Leadership•2007KelloggEyecenterresident Teaching Award

PublicationsHuynh TH, Johnson MW, Comer GM, Fish D. Vitreous penetration of orally admin-istered valacyclovir. Am J ophthalmol 2008;145:682-6.

Chong DY, Comer GM, Trobe JD. Optic disc edema, cystoid macular edema, and elevated vascular endothelial growth factor in a PO-EMS syndrome patient. J neuro-ophthalmol 2007;27:180-3.

comergM,JohnsonMW.coats’diseaseand Retinal Telangiectasia. In: Albert, Miller, Azar, Blodi, eds, Albert and Jakobiec’s Principles and Practice of ophthalmology, 3rd ed. Philadelphia, PA: Elsevier, 2008

Theresa M. Cooney, M.D.

Awards/Honors/Leadership•representativeoftheMichiganSociety of Eye Physicians and Surgeons to the Michigan State Medical Society

PublicationsCooney TM, Johnson CS, Elner VM. Keratomalacia due to psychiatric-induced dietary restrictions [Case Report]. cornea 2007;26:995-7.

Wayne T. Cornblath, M.D.

Awards/Honors/Leadership•Best doctors in America•Member,Educationliaisoncommittee, American Academy of Ophthalmology•co-moderator,Managementofcommon Neuro-Ophthalmic Conditions: Critical Initial Steps in Management - 2007 AAO Neuroophthalmolgy Symposium•director,doubleornothing–diplopia Diagnosis & Management. Indian Health Service Biennial Eye Care Conference•director,VisualFieldlosswithanatomic Correlation. Indian Health Service Biennial Eye Care Conference•director,nowYouSeeit,nowYouKnow It: Pathognomonic Signs. Indian Health Service Biennial Eye Care Conference•director,anisocoria.indianhealthService Biennial Eye Care Conference

PublicationsStephens T, Parmar H, Cornblath W. Giant tumefactive perivascular spaces [short com-munication]. J neurol Sci 2008;266:171-3.

Elner VM, Park S, Cornblath W, Hackel R, Pettyhr.Flavoproteinautofluorescencedetection of early ocular dysfunction. Arch ophthalmol 2008;126:259-60.

Cornblath WT. Optic pathway glioma. In: Kashii S, ed. Ophthalmology: clinical neuro-ophthalmology. Kanehara & Co., 2008, pp. 330-2.

Cornblath WT. Optic nerve sheath meningio-ma In: Kashii S, ed. ophthalmology: clinical neuro-ophthalmology. Kanehara & Co., 2008, pp. 322-5.

Sisson JC, Schipper MJ, Nelson CC, Cornblath WT, Freitas JE, Frueh BR. Radioio-dine therapy and thyroid eye disease. J nuc Medicine 2008;49:923-30.

Margolin E, Cornblath W, Hackel R. Retinal vasculitis due to systemic lupus erythema- tosus. Arch ophthalmol 2008;126:126.

Monte A. Del Monte, M.D.


Awards/Honors/Leadership•Best doctors in America•SpecialinvitedguestSpeaker, III Congresso Brasileiro de Estrabismo e Ophthalmologia Pediatrica, IV Congresso Nacional de Oftalmologia da SBO, Rio de Janeiro, Brazil•davidFriendlyawardandlecturer, Costenbader Pediatric Ophthalmology Society•Specialinvitedguestlecturer,57thannual Postgraduate Course, Syracuse University•chairman,Programcommittee,american Orthoptic Council •chairman,internationalaffairscommittee, American Association for Pediatric Ophthalmology and Strabismus•reviewPanel,Journal of Pediatric ophthalmology and Strabismus•MedicaladvisoryBoard,Knight’sTemplar Eye Research Foundation

Outreach•orBiSinternationalFlyingEyehospital, Pediatric Visiting Professor and Mentor, Big Ten Challenge, Da Nang Eye Hospital, Da Nang, Vietnam

PublicationsEibschitz-Tsimhoni M, Archer SM, Del Monte MA. Intraocular lens power calculation in children. Surv ophthalmol 2007;52:474-82.

delMonteMa,o’KeefeM,Johnsona.Immediate postoperative strabismus man-agement. J Pediatr ophthalmol Strab 2007;44:330-2.

FACULTY HONORS, RECOGNITION, AND PUBLICATIONS


Kemper AR, Gurney JG, Eibschitz-Tsimhoni M, Del Monte MA. Corrective lens wear amongadolescents:findingsfromthenation-al Health and Nutrition Examination Survey.J Pediatr ophthalmol Strabismus 2007;44:356-62.

Eibschitz-Tsimhoni M, Archer SM, Furr BA, Del Monte MA. Current concepts in the management of concomitant exodeviations. compr ophthalmol update 2007;8:213-23.

Peters E, Del Monte MA. The pediatric eye examination. In: Reddy V, Greydanus DE, Feinberg AN, et al., eds. Degowin’s The Pe-diatric diagnostic examination, Philadelphia:McGraw Hill, 2007; Chap 7:137-58.

Kothary PC, Del Monte MA. Impaired signal transduction in human pigment epi-thelial cells from patients with age related macular degeneration. Adv exp Med Biol 2008;613:269-75.

Pediatric Eye Disease Investigator Group. Primary treatment of nasolacrimal duct obstruction with probing in children younger than 4 years of age. ophthalmology 2008;114:577-84.

Eibschitz-Tsimhoni M, Archer SA, Del Monte M. Effect of axial length and keratometry measurement error on intraocular lens im-plant power prediction formulas in pediatric patients. J AAPoS 2008;12:173-6.

Del Monte MA. Sturge-Weber syndrome. In: Fraunfelder FT, Roy H, eds. current ocular Therapy, 6th ed. Philadelphia:Saunders Else-vier 2008; Chap 105:195-9.

Furr BA, Del Monte MA. Long-term outcome after surgical treatment for superior oblique palsy. In: Ryndberg A, Stephenson G, van lammerenM,eds.reflectionsonthediversityof Current Orthoptics. Transactions of the Xi international orthoptic Association congress. Verantwoordelijke uitgever 2008; pp. 282-5.

Del Monte MA. Ocular anatomy and physiol-ogy. In: Rudolph C, Lister G, Gershon A, First L, Rudolph A, eds. Rudolph’s Pediatrics, 22nd ed, New York:McGraw-Hill 2008 [in press].

Enzenauer R, Del Monte MA. Strabismus. In: Rudolph C, Lister G, Gershon A, First L, Rudolph A, eds. Rudolph’s Pediatrics, 22nd ed, New York:McGraw-Hill 2008 [in press]

Kemper AR, Del Monte MA. Vision screening and interpretation. In: Weitzman M, Tanski S, Garfunkel L, eds. Bright Futures in Practice, Pediatric Preventive Services Manual. San Francisco:American Academy of Pediatrics 2008 [in press].

Jonathan B. Demb, Ph.D.


Awards/Honors/Leadership•EditorialBoard,Journal of neuroscience•Keynotespeaker,Europeanretina Meeting, Frankfurt

PublicationsDemb JB. Cellular mechanisms for direction selectivity in the retina. neuron 2007;55:179-86.

Demb JB, von Gersdorff H. Ultraweak signals can cause synaptic depression and adapta-tion. neuron 2008;57:802-4.

Manookin MB, Beaudoin DL, Ernst ZR, Flagel LJ, Demb JB. Disinhibition combines with ex-citation to extend the operating range of the OFF visual pathway in daylight. J neurosci 2008;28:4136-50.

Maya Eibschitz, M.D.

PublicationsKemper AR, Gurney JG, Eibschitz-Tsimhoni M, Del Monte MA. Corrective lens wear amongadolescents:findingsfromthenation-al Health and Nutrition Examination Survey.J Pediatr ophthalmol Strabismus 2007;44:356-62.

Eibschitz-Tsimhoni M, Archer SM, Del Monte MA. Intraocular lens power calcula-tion in children. [Review] Surv ophthalmol 2007;52:474-82.

Eibschitz-Tsimhoni M, Archer SM, Furr BA, Del Monte MA . Current concepts in the management of concomitant exodevia-tions [Review]. comp ophthalmol update 2007;8:213-23.

Eibschitz-Tsimhoni M, Archer SM, Del Monte MA. Effect of axial length and keratometry measurement error on intraocular lens im-plant power prediction formulas in pediatric patients. J AAPoS 2008;12:173-6.

Susan G. Elner, M.D.


Awards/Honors/Leadership•Best doctors in America•Thesisreviewcommittee,american Ophthalmological Society•adhocmember,neurobiologyc, Veterans Affairs Merit Review Committee•SectionEditor,eye

PublicationsYang D, Elner SG, Bian Z-M, Till GO, Petty hr,ElnerVM.Pro-inflammatorycytokinesincrease reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells. exp eye Res 2007;85:462-72.

Demirci H, Hassan AS, Elner SG, Boehlke C, Elner VM. Comprehensive, combined anterior and transcaruncular orbital approach to me-dial canthal ligament plication. ophthalmic Plast Reconstr Surg 2007;23:384-8.

Elner SG, Elner VM, Field MG, Park S, Yang D, Heckenlively JR, Petty HR. Retinal flavoproteinautofluorescenceasameasureof retinal health. Trans Am ophthalmol Soc 2008 [in press].

Victor M. Elner, M.D., Ph.D.


Awards/Honors/Leadership•Best doctors in America•ravitzFoundationProfessorof Ophthalmology & Visual Sciences•Boardofdirectors,americanassociation of Ophthalmic Pathologists

PublicationsBoehlke CS, Frueh BR, Flint A, Elner VM. Malignantfibroushistiocytomaofthelateralconjunctiva and anterior orbit. ophthalmic Plast Reconstr Surg 2007;23:338-42.

Cooney T, Johnson CS, Elner VM. Kera-tomalacia due to psychiatric-induced dietary restrictions [Case Report]. cornea 2007;26:995-7.

Yang D, Elner SG, Bian ZM, Till GO, Petty hr,ElnerVM.Pro-inflammatorycytokinesincrease reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells. exp eye Res 2007;85:462-72.

Demirci H, Hassan AS, Elner SG, Boehlke C, Elner VM. Comprehensive, combined anterior and transcaruncular orbital approach to me-dial canthal ligament plication. ophthalmic Plast Reconstr Surg 2007;23:384-8.

Yen KG, Elner VM, Musch DC, Nelson CC. Periocular versus general anesthesia for ocu-lar enucleation. ophthalmic Plast Reconstr Surg 2008;1:24-8.

Demirci H, Elner VM. Double bicanalicular silicone intubation for management of partial lacrimal drainage obstruction in adults. ophthalmology 2008;115:383-5.

Demirci H, Vine AK, Elner VM. Choroidal metastasis from submandibular salivary gland adenoid cystic carcinoma. ophthalmic Surg lasers imaging 2008;39:57-9.

Elner VM, Park S, Cornblath W, Hackel R, Pettyhr.Flavoproteinautofluorescencedetection of early ocular dysfunction. Arch ophthalmol 2008;126:259-60.




Victor M. Elner, cont’d Demirci H, Elner VM. Tumors of soft tissue. In: Klintworth GK, Garner A, Heathcote JG, Cameron JD, Elner VM, Rao NA, eds. gar-ner & Klintworth’s Pathobiology of Ocular disease. Taylor & Francis, New York 2008. Chap 57, pp. 1371-96.

Elner VM. Apoptosis. In: Klintworth GK, Garner A, Heathcote JG, Cameron JD, Elner VM, Rao NA, eds. Garner & Klintworth’s Pathobiology of ocular disease. Taylor & Francis, New York 2008. Chap 2, pp.29-45.

Hassan AS, Elner VM. Optic Nerve Glioma. In: Tasman W, Jaeger EA, eds. Duane’s Clini-cal ophthalmology. Lippincott, Williams & Wilkins, Philadelphia, PA. 2008 [in press].

Kahana A, Pribila JT, Nelson CC, Elner VM. Sebaceous cell carcinoma. In: Albert DM, Levin LA, eds, ocular disease: Mechanisms and Management. New York:Elsevier, 2008 [in press].

Field MG, Elner VM, Puro DG, Feuerman J, Musch DC, Pop-Busui R, Hackel R, Heckenliv-ely JR, Petty HR. Rapid, non-invasive detec-tion of diabetes-induced retinal metabolic stress. Arch ophthalmol 2008 [in press].

Shtein RM, Garcia DD, Musch DC, Elner VM. HSV keratitis: histopathologic predictors of corneal allograft complications. Trans Am ophthalmol Soc 2008 [in press].


Scott GR, Frueh BR, Flint A, Elner VM. Fibrous dysplasia of the lacrimal sac. ophthalmic Plast Reconstr Surg 2008 [in press].

Nelson CC, Pribila JT, Elner VM, Flint A, Frueh BR. Carcinoid tumors of the orbit: a clinicopathological review. Graefe’s Arch clin & exp ophth 2008 [in press].

Bartley R. Frueh, M.D.

Awards/Honors/Leadership• Best Doctors in America

PublicationsBoehlke CS, Frueh BR, Flint A, Elner VM. Malignantfibroushistiocytomaofthelateralconjunctiva and anterior orbit. ophthalmic Plast Reconstr Surg 2007;23:338-40.

Sisson JC, Schipper MJ, Nelson CC, Corn blath WT, Freitas JE, Frueh BR. Radioiodine therapy and thyroid eye disease. J nucl Medicine 2008;49:923-30


Scott GR, Frueh BR, Flint A, Elner VM. Fibrous dysplasia of the lacrimal sac. ophthalmic Plast Reconstr Surg 2008 [in press].

Demirci H, Johnson T, Frueh BR, Musch DC, Fullen D, Nelson CC. Management of peri-ocular cutaneous melanoma with a staged excision technique and permanent sections: the “square procedure.” ophthalmology 2008 [in press].

Bruce A. Furr, C.O.

Awards/Honors/Leadership•President-elect,americanassociation ofcertifiedorthoptists

PublicationsEibschitz-Tsimhoni M, Archer SM, Furr BA, Del Monte MA. Current concepts in the man-agement of concomitant exodeviations. comp ophthalmol update 2007;8:213-23.

Furr BA, Del Monte MA. Long-term outcome after surgical treatment for superior oblique palsy. In: Ryndberg A, Stephenson G, van lammerenM,eds.reflectionsonthediversityof Current Orthoptics. Transactions of the Xi international orthoptic Association congress. Verantwoordelijke uitgever 2008; pp. 282-5.

Philip J. Gage, Ph.D.


PublicationsTessari A, Pietrobon M, Notte A, Cifelli G, Gage PJ, Schneider MD, Lembo G, Campi-one M. Myocardial Pitx2 differentially regu-lates the left atrial identity and ventricular asymmetric remodeling programs. circ Res 2008;102:813-22.

Gage PJ, Qian M, Wu D, Rosenberg KI. The canonical Wnt signaling antagonist DKK2 is an essential effector of PITx2 function during normal eye development. dev Biol 2008;317:310-24.

Richard E. Hackel, C.R.A.

Awards/Honors/Leadership•Sectioneditor,“Blink,”eyenet •EditorialBoard,Journal of ophthalmic Photography •EditorialBoard,eyenet •EditorialBoard,Journal of neuro- ophthalmology

Publications Margolin E, Cornblath W, Hackel R. Retinal vasculitis due to systemic lupus erythema- tosus. Arch ophthalmol 2008;126:126.

Elner V, Park S, Cornblath W, Hackel R, Petty h.Flavoproteinautofluorescencedetectionof early ocular dysfunction. Arch ophthalmol 2008;126:259-60.

Field MG, Elner VM, Puro DG, Feuerman J, Musch DC, Pop-Busui R, Hackel R, Heckenliv-ely JR, Petty HR. Rapid, non-invasive detec-tion of diabetes-induced retinal metabolic stress. Arch ophthalmol 2008 [in press].

John R. Heckenlively, M.D.


Awards/Honors/Leadership•Best doctors in America•associateEditor,eye •EditorialBoard,documenta ophthalmologica•EditorialBoard,Journal of ocular Biology•EditorialBoard,diseases and informatics•EditorialBoard,clinical ophthalmology

PublicationsGire AI, Sullivan LS, Bowne SJ, Birch DG, Hughbanks-Wheaton D, Heckenlively JR, Daiger SP. The Gly56Arg mutation in NR2E3 accounts for 1-2% of autosomal dominant retinitis pigmentosa. Mol Vis 2007;13:1970-5.

Atmaca-Sonmez P, Khan NW, Heckenlively JR. Hereditary cone dystrophies. In: Albert D, Miller J, Azar D, Blodi B, eds. Principles and Practice of ophthalmology, Philadel-phia:WB Saunders 2008, Chap 178, pp. 2253-60.

Atmaca-Sonmez P, Heckenlively JR. Genetic disorders of the retina and optic nerve. In: Garner A, Klintworth G, eds. Pathobiology of ocular disease, 3rd ed. Informa Health-care 2008, Chap 35. pp. 751-84.

Chang B, Hawes NL, Davisson MT, Hecken-lively JR. Mouse models of RP. In: Tombran-Tink J, Barnstable CJ, eds., ophthalmology Research: Retinal degenerations: Biology, diagnostics, and Therapeutics. Humana Press Inc.:Totowa, NJ 2008, pp. 149-61.

Daiger SP, Sullivan LS, Gire AI, Birch DG, Heckenlively JR, Bowne SJ. Mutations in known genes account for 58% of autosomal dominant retinitis pigmentosa (adRP). Adv exp Med Biol 2008;613:203-9.

Heckenlively JR, Ferreyra H. Autoimmune retinopathy: a review and summary. Semin immunopathol 2008;30:127-34.

Shimazaki K, Jirawuthiworavong GV, Hecken-lively JR, Gordon LK. Frequency of anti- retinal antibodies in normal human serum. J neuro-ophthalmol 2008;28:5-11.



Small KW, Silva-Garcia R, Udar N, Nguyen EV, Heckenlively JR. New mutation, P575L, in the GUCY2D gene in a family with autosomal dominant progressive cone degeneration. Arch ophthalmol 2008;126:397-403.

Bowne SJ, Sullivan LS, Gire AI, Birch DG, Hughbanks-Wheaton D, Heckenlively JR, Daiger SP. Mutations in the TOPORS gene cause 1% of autosomal dominant retinitis pigmentosa. Mol Vis 2008;14:922-7.

Moroi SE, Heckenlively JR. Progress toward personalized medicine for age-related macu-lar degeneration [editorial]. ophthalmology 2008;115:925-6.

Field MG, Elner VM, Puro DG, Feuerman J, Musch DC, Pop-Busui R, Hackel R, Heckenlively JR, Petty HR. Rapid, non-inva-sive detection of diabetes-induced retinal metabolic stress. Arch ophthalmol 2008 [in press].

Peter F. Hitchcock, Ph.D.


Awards/Honors/Leadership•invitedlecturer,MidwestZebrafish Meeting, Notre Dame, IN•director,universityofMichigan Interdepartmental Neuroscience Graduate Program•chair(adhoc),cellBiologyreviewPanel•neurogenesisandcellFatereviewPanel•chair(adhoc)Molecular,developmental, Cellular Neuroscience Review Panel, NIH

Bret A. Hughes, Ph.D.


Awards/Honors/Leadership•Member,SpecialEmphasisPanel,national Eye Institute, NIH•director,universityofMichigancore Center for Vision Research

PublicationsYang D, Swaminathan A, Zhang x, Hughes BA. Expression of Kir7.1 and a novel Kir7.1 splice variant in native human retinal pigment epithelium. exp eye Res 2008;86:81-91.

Hughes BA, Swaminathan A. Modulation of the Kir7.1 potassium channel by extracel-lular and intracellular pH. Am J Physiol cell Physiol 2008;294:C423-31.

Yang D, Zhang x, Hughes BA. Expression of inwardly rectifying potassium channel sub-units in native human retinal pigment epithelium. exp eye Res 2008 [in press].

Mark W. Johnson, M.D.


Awards/Honors/Leadership•Best doctors in America•guidetoamerica’sTopophthalmologists•Member,PeriodicophthalmicreviewTests (PORT) Panel, American Board of Ophthalmology•chairperson,nominatingcommittee, Macula Society•Williamh.Knoblochlecturer,university of Minnesota, Minneapolis•Moderator,Fluoresceinangiography Conference, Macula Society Annual Meeting, London•Member,dataandSafetyMonitoring Committee: Comparison of Age-related Macular Degeneration Treatments Trials (CATT), National Eye Institute, NIH•EditorialBoard,American Journal of ophthalmology •EditorialBoardMember,Retina•EditorialBoardMember,Retinal Physician

PublicationsChang TS, Bressler NM, Fine JT, et al, for the MARINA Study Group. Improved vision- related function after ranibizumab treatment of neovascular age-related macular degen-eration: Results of a randomized clinical trial. Arch ophthalmol 2007;125:1460-70.

Wu RA, Best RM, Musch DC, Johnson MW. Surgical removal of subfoveal choroidal neovascular membranes in older patients without age-related macular degeneration. clin ophthalmol 2007;1:157-65.

Regillo C, Holekamp N, Johnson MW, Kaiser PK, Schubert H, Schmidt-Efurth U, Spaide R. Retina and Vitreous (Section 12). Basic and clinical Science course. San Francisco:American Academy of Ophthalmology, 2008-2009.

Huynh TH, Johnson MW, Comer GM, Fish DN. Vitreous penetration of orally ad-ministered valacyclovir. Am J ophthalmol 2008;145:682-6.

comergM,JohnsonMW.coats’diseaseand Retinal Telangiectasia. In: Albert, Miller, Azar, Blodi, eds, Albert and Jakobiec’s Principles and Practice of ophthalmology, 3rd ed. Philadelphia, PA: Elsevier, 2008

Conrad PW, Zacks DN, Johnson MW. Intra-vitrealbevacizumabhasinitialclinicalbenefitlasting eight weeks in eyes with neovascular age-related macular degeneration. clin oph-thalmol 2008 [in press].

Taich A, Johnson MW. A syndrome resem-bling acute posterior multifocal placoid pig-ment epitheliopathy in older adults. Trans Am ophthalmol Soc 2008 [in press].

Chong DY, Johnson MW. Vitelliform macular detachment associated with basal laminar drusen is unresponsive to vascular endothelial growth factor blockade. Ret cases Brief Rep 2008 [in press].

Alon Kahana, M.D., Ph.D.


Awards/Honors/Leadership•Member,americanSocietyofophthalmic Plastic and Reconstructive Surgery•Member,universityofMichigan Comprehensive Cancer Center•Member,Scientificadvisorycommittee, International Thyroid Eye Disease Society

PublicationsKahana A, Lucarelli MJ, Grayev AM, Van Buren JJ, Burkat CN, Gentry LR. Noninva- sive dynamic magnetic resonance angio- graphy with time-resolved imaging of con-trast kineticS (TRICKS) in the evaluation of orbital vascular lesions. Arch ophthalmol 2007;125:1635-42.

Kahana A, Lucarelli MJ. Use of radiopaque intraorbital catheter in the treatment of sino-orbito-cranial mucormycosis. Arch ophthal-mol 2007;125:1714-15.

Kahana A, Levin LA. Peripheral nerve tumors of the orbit. In: Albert DA, Miller JW, eds., Albert and Jakobiec’s Principles and Practice of ophthalmology, 3rd ed. Philadelphia:WB Saunders 2007.

Langenberg T, Kahana A, Wszalek JA, Hal-loran MC. The eye organizes neural crest cell migration. dev dyn 2008;237:1645-52.

Kahana A, Lucarelli MJ. Corneal protective procedures: tarsorrhaphy and lacrimal occlu-sion. In: Brightbill FS, McDonnell PJ, McGhee CNJ, Farjo AA, Serdarevic O, eds. corneal Surgery, 4th ed. New York:Elsevier 2008 [in press.]

Kahana A, Lucarelli MJ, Burkat CN, Dortz-bach RK. Diagnosis and management of orbital fractures. In: Mallajosyula S, ed., Surgical Atlas of the orbit, Delhi, India:Jaypee Brothers 2008 [in press].

Lucarelli MJ, Ahn HB, Kulkarni A, Kahana A. Intratarsal epidermal inclusion cyst. ophthal Plast Reconstr Surg 2008 [in press].

Kahana A, Lucarelli MJ. Adjunctive trans-canthotomy lateral suborbicularis fat (SOOF) lift and orbitomalar ligament resuspension in lower lid ectropion repair. ophthal Plast Reconstr Surg 2008 [in press].



Naheed W. Khan, Ph.D.

PublicationsKhan NW, Wissinger B, Kohl S, Sieving PA. CNGB3 achromatopsia with progressive loss of residual cone function and impaired rod-mediated function. invest ophthalmol Vis Sci 2008;48:3864-71.

Feathers KL, Lyubarsky AL, Khan NW, TeofiloK,Swaroopa,WilliamsdS,PughEN Jr, Thompson DA. RPE65 is necessary for chromophore synthesis and outer segment morphogenesis in the cone photoreceptors of the Nrl knockout mouse. invest ophthalmol Vis Sci 2008;49:1126-35.

Atmaca-Sonmez P, Khan NW, Heckenlively JR. Hereditary cone dystrophies. In: Albert D, Miller J, Azar D, Blodi B, eds. Principles and Practice of ophthalmology, Philadelphia:WB Saunders 2008, Chap 178, pp. 2253-60.

Oh ECT, Cheng H, Hao H, Jia L, Khan NW, Swaroop A. The rod differentiation factor NRL activates the expression of the nuclear receptor NR2E3 to suppress cone photore-ceptor development. Brain Res 2008 [in press].

Hemant Khanna, Ph.D.


Awards/Honors/Leadership•rd2008Younginvestigatoraward,Travel Fellowship, xIII International Symposium on Retinal Degenerations•reviewer,FightforSight•reviewer,italianTelethonFoundation for Curing Genetic Diseases•Member,Proposalreviewcommittee, University of Michigan Undergraduate Research Opportunity Program •Member,Professionaldevelopmentand Education Committee, Association for Research in Vision and Ophthalmology•organizer,Specialinterestgroup Meeting: Ciliary Proteins and Retinal Degeneration: New Perspectives and Future Directions; Association for Research in Vision and Ophthalmology

PublicationsChakarova CF, Papaioannou MG, Khanna H, et al. Mutations in TOPORS cause auto-somal dominant retinitis pigmentosa with perivascular RPE atrophy. Am J Hum genet 2007;81:1098-103.

Cideciyan AV, Aleman TS, Jacobson SG, Khanna H, Sumaroka A, Aguirre GK, Schwartz SB, Windsor EA, He S, Chang B, Stone EM, Swaroop A. Centrosomal-ciliary gene CEP290/NPHP6 mutations result in blindness with unexpected sparing of photo-receptors and visual brain: implications for therapy of Leber congenital amaurosis. Hum Mut 2007;28:1074-83.

McEwen DP, Koenekoop RK, Khanna H, Jenkins PM, Lopez I, Swaroop A, Martens JR. Hypomorphic CEP290/NPHP6 mutations re-sult in anosmia due to the selective loss of G proteins in cilia of olfactory sensory neurons. Proc natl Acad Sci 2007;104:15917-22.

He S, Parapuram SK, Hurd TW, Behnam B, Margolis B, Swaroop A, Khanna H. Retinitis pigmentosa GTPase regulator (RPGR) protein isoforms in mammalian retina: insights into x-linked retinitis pigmentosa and associated ciliopathies. Vis Res 2008;48:366-76.

Siffroi-Fernandez S, Felder-Schmittbuhl M, Khanna H, Swaroop A, Hicks D. FGF19 exhibits neuroprotective effects on adult mammalian photoreceptors in vitro. invest ophthalmol Vis Sci 2008;49:1696-704.

Thellea K. Leveque, M.D., M.P.H.


PublicationsLeveque TK, Yu L, Musch DC, Chervin RD, Zacks DN. Central serous chorioretinopathy and risk for obstructive sleep apnea. Sleep and Breathing 2007;11:253-7.

Erika M. Levin, M.D.


Awards/Honors/Leadership•co-chair,YoungophthalmologistSection, Michigan Society of Eye Physicians and Surgeons•Member,Membershipcommittee, American Association for Pediatric Ophthalmology and Strabismus•Member,Bylawsandrulescommittee, American Association for Pediatric Ophthalmology and Strabismus•invitedlecturer,departmentofPediatrics, William Beaumont Hospital, Royal Oak, Michigan

PublicationsWest AL, Levin EM. Ocular injuries. In: Meredith FL, Schwab W, Taheri P, Trunkey D, eds. Trauma: contemporary Principles and Therapy. Philadelphia:Lippincott, Williams and Wilkins, 2007.

Pediatric Eye Disease Investigator Group. Pri-mary treatment of nasolacrimal duct obstruc-tion with probing in children younger than 4 years. ophthalmology 2008;115:577-84.

Paul R. Lichter, M.D.


Awards/Honors/Leadership•Best doctors in America

•lucienhoweMedal,american Ophthalmological Society•associateEditor,American Journal of ophthalmology•Secretarygeneral,academia Ophthalmologica Internationalis•rogerP.Masonlecturer,national Medical Association

PublicationsJampel HD, Frick KD, Janz NK, Wren PA, Musch DC, Rimal R, Lichter PR. Depression and mood indicators in newly diagnosed glaucoma patients. Am J ophthalmol 2007;144:238-44.

Janz NK, Wren PA, Guire KE, Musch DC, Gillespie BW, Lichter PR. Fear of blindness in the Collaborative Initial Glaucoma Treatment Study: patterns and correlates over time. ophthalmology 2007;114:2213-20.

Musch DC, Gillespie BW, Niziol LM, Cash-well LF, Lichter PR. Factors associated with intraocular pressure before and during nine years of treatment in the Collaborative Initial Glaucoma Treatment Study. ophthalmology 2008;115:927-33.

Lichter PR, Musch DC, Janz NK. The inves-tigators’perspectiveonthecollaborativeInitial Glaucoma Treatment Study (CIGTS). Arch ophthalmol 2008;126:122-24.

Lichter PR. Harold F. Falls, MD (1909-2006) [obituary]. Arch ophthalmol 2008;126:585-6.

Lichter PR. Robert N. Shaffer, MD (1912-2007) [obituary]. Am J ophthalmol 2008;146:143-4.

lichterPr.debunkingmythsinphysician– industryconflictsofinterest[perspective]. Am J ophthalmol 2008 [in press].

Lichter PR. CME, physicians and Pavlov: can we change what happens when industry rings the bell? [editorial]. Arch ophthalmol 2008 [in press].

Michael J. Lipson, O.D.


Awards/Honors/Leadership•invitedlecturer,claoEducational Research Foundation•invitedlecturer,illinoiscollegeof Optometry

PublicationsLipson MJ, Musch DC. Synergeyes vs. soft toric lenses: vision-related quality of life. optom Vis Sci 2007;84:7:593-7.

Lipson MJ. Long-term clinical outcomes of overnight corneal reshaping in children and adults. eye and contact lens 2008;34:2:94-9.



Shahzad I. Mian, M.D.


Awards/Honors/Leadership•Best doctors in America•anthonyadamisPrizeforoutstanding Research in Ophthalmology and Visual Sciences, University of Michigan, W.K. Kellogg Eye Center•leadershipdevelopmentProgram, American Academy of Ophthalmology•EmployeeoftheYear,universityof Michigan, W.K. Kellogg Eye Center•Boardofdirectors,MidwestEyeBank•Programdirectors’council–Teaching and Learning Symposium Committee, American Academy of Ophthalmology•Editor,“cornea,” ophthalmic news and education network, American Academy of Ophthalmology

PublicationsMian SI, Shtein RM, Nelson A, Musch DC. Effectiveness of hinge position on corneal sensation and dry eyes after LASIK with Intra- lase. J cataract Refract Surg 2007;33:1190-4.

Ahmad OR, Mian SI, Sugar A. Future of keratoplasty. In: Brightbill FS, ed. corneal Surgery, St. Louis:CV Mosby 2008 [in press].

Trizcinka A, Mian SI. Corneal biopsy. In: Dunn JP, Langer P, eds. Basic Techniques in ophthalmic Surgery, San Francisco:American Academy of Ophthalmology 2008 [in press].

Schneider E, Mian SI. Recommended practices for femtosecond laser in refractive surgery. Am Soc ophthalmic Reg nurses 2008 [in press].

Malta J, Ahmad FK, Mian SI, Sugar A. Cor-nealinflammatorydisorders.in:TrattlerW,Majmudar P, Luchs J, eds: cornea essentials. Thorofare, New Jersey:Slack Inc. 2008 [in press].

Sayoko E. Moroi, M.D., Ph.D.


Awards/Honors/Leadership•Best doctors in America•alphaomegaalpha,gammachapter of Ohio

PublicationsMian SI, Shtein R, Nelson A, Musch DC. Effectiveness of hinge position on corneal sensation and dry eyes after LASIK with Intra-lase. J cat Refract Surg 2007;33:1190-4.

Rozsa F, Scott K, Pawar H, Moroi S, Richards JE. Effects of timolol on MYOC, OPTN, and WDR36 RNA levels. Arch ophthalmol 2008;126:86-93.

Moroi SE, Richards JE. Glaucoma and ge-nomic medicine: research results. glaucoma Today 2008;6(1):16-24.

Roberts DK, Ayyagari R, Moroi SE. Possible association between long anterior lens zon-ulesandplateauirisconfiguration. J glaucoma 2008 [in press].

Moroi SE, Heckenlively JR. Progress toward personalized medicine for age-related macu-lar degeneration [editorial]. ophthalmology 2008;115:925-6.

Roberts DK, Lukic A, Yang Y, Moroi SEM, Wilensky JT, Wernick MN. Novel observa-tions and potential applications using digital infrared iris imaging. ophthalmic Surg lasers imaging 2008 [in press].

Trzcinka A, Soans FP, Archer SM, Moroi SE. Late-onset Haemophilus influenzae endo-phthalmitis in a child following Baerveldt implant. J AAPoS 2008 [in press].

David C. Musch, Ph.D., M.P.H.


Awards/Honors/Leadership•EditorialBoard,ophthalmology•EditorialBoard,Retina•ScientificadvisoryBoard, Clinical and Translational Science Award, Michigan Institute for Clinical and Health Research•consultingEditorialBoard, Journal of neuro-ophthalmology•chair,SpecialEmphasisgrantreview Panel, National Eye Institute, NIH•Methodologist,cornea/anteriorSegment Panel, Ophthalmic Technology Assessment Committee, American Academy of Ophthalmology•Methodologist,corneaandExternal Disease Preferred Practice Pattern Panel, American Academy of Ophthalmology•reviewer,nationalMedicalresearch Council, Singapore•Member,advisorygroup,cochrane Collaboration Eyes and Vision Group US Project•Expertgroupcoremember,Visionand Hearing Loss Expert Group, Noncommunicable Diseases Cluster, Global Burden of Diseases Study•invitedspeaker,10thannualFda-ocra Educational Conference, Irvine, CA

PublicationsLipson MJ, Musch DC. Synergeyes vs. soft toric lenses: vision-related quality of life. optom Vis Sci 2007;84:593-7.

Mian SI, Shtein R, Nelson A, Musch DC. Effectiveness of hinge position on corneal sensation and dry eyes after LASIK with Intra-lase. J cat Refract Surg 2007;33:1190-4.

Garcia DD, Farjo Q, Musch DC, Sugar A. The effect of prophylactic oral acyclovir after penetrating keratoplasty for herpes simplex keratitis. cornea 2007;26:930-4.

Leveque TK, Yu L, Musch DC, Chervin RD, Zacks DN. Central serous chorioretinopathy and risk for obstructive sleep apnea. Sleep and Breathing 2007;11:253-7.

Jampel HD, Frick KD, Janz NK, Wren PA, Musch DC, Rimal R, Lichter PR. Depression and mood indicators in newly diagnosed glaucoma patients. Am J ophthalmol 2007;144:238-44.

Wu RA, Best RM, Musch DC, Johnson MW. Surgical removal of subfoveal choroidal neovascular membranes in older patients without age-related macular degeneration. clin ophthalmol 2007;1:157-65.

Janz NK, Wren PA, Guire KE, Musch DC, Gillespie BW, Lichter PR. Fear of blindness in the Collaborative Initial Glaucoma Treatment Study patterns and correlates over time. ophthalmology 2007;114:2213-20.

Musch DC, Gillespie BW, Niziol LM, Cash-well LF, Lichter PR. Factors associated with intraocular pressure before and during nine years of treatment in the Collaborative Initial Glaucoma Treatment Study. ophthalmology 2008;115:927-33.

Lichter PR, Musch DC, Janz NK. The inves-tigators’perspectiveonthecollaborativeInitial Glaucoma Treatment Study (CIGTS). Arch ophthalmol 2008;126:122-4.

Hall EF, Scott GR, Musch DC, Zacks DN. Adjunctive intravitreal dexamethasone in the treatment of acute endophthalmitis follow-ing cataract surgery. clinical ophthalmol 2008;2:139-45.

Yen KG, Elner VM, Musch DC, Nelson CC. Periocular versus general anesthesia for ocu-lar enucleation. ophthal Plast Reconstr Surg 2008; 24:24-8.

Luttrull JK, Musch DC, Spink CA. Subthresh-old diode micropulse panretinal photocoagu-lation for proliferative diabetic retinopathy. eye 2008; 22:607-12.


Field MG, Elner VM, Puro DG, Feuerman JM, Musch DC, Pop-Busui R, Hackel R, Heckenliv-ely JR, Petty HR. Rapid non-invasive detection of diabetes-induced retinal metabolic stress. Arch ophthalmol 2008 [in press].



David C. Musch, cont’d Shtein RM, Garcia DD, Musch DC, Elner VM. HSV keratitis: histopathologic predictors of corneal allograft complications. Trans Am ophthalmol Soc 2008 [in press].

Christine C. Nelson, M.D.


Awards/Honors/Leadership•Best doctors in America•Topdoctor, Hour detroit•guidetoamerica’sTopophthalmologists•Seniorachievementaward,american Academy of Ophthalmology

PublicationsYen K, Elner V, Musch DC, Nelson CC. Peri-ocular versus general anesthesia for ocular enucleation. ophthal Plast Reconstr Surg 2008;24: 24-8.

Sisson JC, Schipper MJ, Nelson CC, Corn- blath WT, Freitas JE, Frueh BR. Radioiodine therapyandgraves’ophthalmopathy.J nucl Med 2008;49:923-30.

Demirci H, Marentette LJ, Nelson CC. The transglabellar, subcranial approach for surgi-cal excision of periocular second tumors in retinoblastoma. orbit 2008 [in press].




Howard R. Petty, Ph.D.


Awards/Honors/Leadership•Winner,greatlakesEntrepreneur’sQuest, OcuSciences

PublicationsPetty HR. Fluorescence microscopy: emerging methods and strategies to extract weak sig-nals with applications in immunology. Micros Res Tech 2007;70:687-70.

Huang J-B, Clark AJ, Petty HR. Preliminary report: the hexosamine biosynthesis pathway negatively regulates IL-2 production by Jurkat T cells. cell immunol 2007;245:1-6.

Zhu A, Huang J-B, Clark AJ, Romero R, Petty HR. 2,5-Deoxyfructosazine, a D-glucosamine derivative, inhibits T cell Interleukin-2 produc-tion better than D-glucosamine. carbohydr Res 2007;342:2745-9.

Yang D, Elner SG, Bian ZM, Till GO, Petty hr,ElnerVM.Pro-inflammatorycytokinesincrease reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells. exp eye Res 2007;85:462-72.

clarkaJ,Pettyhr.Super-quietmicrofluo-rometry: examples of tumor cell metabolic dynamics. In: Méndez-Vilas A, Diaz J, eds. Modern Research education: Topics on Microscopy 2007;3:403-8.

Elner VM, Park S, Cornblath W, Hackel R, Pettyhr.Flavoproteinautofluorescencede-tects early ocular dysfunction in pseudotumor cerebri. Arch ophthalmol 2008;126:259-60.

Hinkovska-Galcheva V, Clark AJ, Hiraoka M, Abe A, Borofsky M, Shayman JA, Lanni F, Petty HR, Boxer LA. Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cells. J lipid Res 2008;49:531-42.

Madsen-Bouterse S, Romero R, xu Y, Petty hr.Quantificationofo-glcnacproteinmodificationinneutrophilsbyflowcytometry.cytometry 2008 [in press].

Field MG, Elner VM, Puro DG, Feuerman J, Musch DC, Pop-Busui R, Hackel R, Heckenliv-ely JR, Petty HR. Rapid, non-invasive detec-tion of diabetes-induced ocular metabolic stress. Arch ophthalmol 2008 [in press].

Clark AJ, Petty HR. Observation of calcium microdomains at the uropod of living morpho-logically polarized human neutrophils using flashlamp-basedfluorescencemicroscopy.cytometry 2008 [in press].

Donald G. Puro, M.D., Ph.D.


Awards/Honors/Leadership•Best doctors in America•EditorialBoardMember,Microcirculation•adhocmember,Biologyanddiseasesof the Posterior Eye Study Section, Center for Scientificreview,nih•adhocmember,nationalEyeinstitute Special Emphasis Panel•invitedspeaker,PhysiologicalSociety (United Kingdom) meeting concerning ion channels and the microcirculation

PublicationsPuro DG. Physiology and pathobiology of the pericyte-containing retinal microvasculature: roles of ion channels and transporters. In: Tombran-Tink J, Barnstable C, eds. ocular Transporters in ophthalmic diseases and drug delivery. Totowa, NJ:Humana Press, 127-37; 2008.

Field MG, Elner VM, Puro DG, Feuerman JM, Musch DC, Pop-Busui R, Hackel R, Heckenliv-ely JR, Petty HR. Rapid non-invasive detection of diabetes-induced retinal metabolic stress. Arch ophthalmol 2008 [in press].

Julia E. Richards, Ph.D.


Awards/Honors/Leadership•reviewer,TheglaucomaFoundation•reviewer,FightforSight.•Member,ScientificadvisoryBoard, The Glaucoma Foundation•Member,Steeringcommittee,Multicenter Study to Map Novel Genes for Fuchs Corneal Endothelial Dystrophy, Case Western Reserve University•director,glaucomaresearchcenter, U-M Kellogg Eye Center•Moduledirector,Microarraycore Module, U-M Kellogg Eye Center •FacultyMember,geneticsinterdepart- mental Concentration, U-M School of Public Health•FacultyMember,u-MVisionScience Training Program•FacultyMember,u-MgenomeSciences Training Program•FacultyMentor,KelloggiansTraineegroup for Trainees in Vision Research•Member,glaucomaresearchSociety, International Congress of Ophthalmology•adhocmember,BoardofScientific Counselors, National Eye Institute, NIH

PublicationsAldave AJ, Yellore VS, Yu F, Bourla N, Son-mez B, Salem AK, Rayner SA, Sampat KM, Krafchak CM, Richards JE. Posterior polymor-phous corneal dystrophy is associated with TCF8 gene mutations and abdominal hernia. Am J Med genet 2007;143:2549-56.

Trager EH, Khanna R, Marrs A, Siden L, Branham K, Swaroop A, Richards JR. Mad-eline 2.0 PDE: A new program for local and web-based pedigree drawing. Bioinformatics 2007;23:1854-6.

Rozsa FW, Scott K, Pawar H, Moroi S, Rich-ards JE. Effects of timolol on MYOC. OPTN and WDR36 RNA levels. Arch ophthalmol 2008;126:86-93.



Guevara-Fujita ML, Perez Grossmann R, Estrada Cuzcano A, Pawar H, Vargas E, Richards JE, Fujita R. Recurrent myocilin Asn480Lys glaucoma causative mutation arises de novo in a family of Andean descent. J glaucoma 2008;17:67-72.

Moroi SE, Richards JE. Glaucoma and ge-nomic medicine: research results. glaucoma Today 2008;6:16-24.

Frank W. Rozsa, Ph.D.

Awards/Honors/Leadership•invitedlecturer,geriatricscenterresearch Symposium, University of Michigan

PublicationsRozsa FW, Scott K, Pawar H, Moroi S, Rich-ards JE. Effects of Timolol on MYOC, OPTN, and WDR36 RNA levels. Arch ophthalmol 2008;126:86-93.

Stephen J. Saxe, M.D.


Outreach•Specialguestlecturer,physician,and mentor: Guatemala City, World Eye Mission

Roni M. Shtein, M.D.


PublicationsMian SI, Shtein RM, Nelson A, Musch DC. Effectiveness of hinge position on corneal sensation and dry eyes after LASIK with Intra- lase. J cataract Refract Surg 2007;33:1190-4.

Sugar A, Mintz R. Koch-Weeks bacillus. In: Roy FH, Fraunfelder F, eds. current ocular Therapy, 6th ed., Philadelphia: WB Saun-ders, 2007.

Shtein RM, Garcia DD, Musch DC, Elner VM. HSV keratitis: histopathologic predictors of corneal allograft complications. Trans Am ophthalmol Soc 2008 [in press].

Banitt MR, Malta JB, Shtein RM, Soong HK. delayed-onsetcentraldescemet’smembranedetachmentfollowingphacoemulsification. J cataract Refract Surg 2008 [in press].

H. Kaz Soong, M.D.


Awards/Honors/Leadership•honorarydiploma,MemberofBulgarian Union of Ophthalmology•invitedspeaker,61stannualcongress of Japanese Clinical Ophthalmology (Kyoto, Japan)

•invitedspeakerandvisitingprofessor, National Taiwan University Hospital (Taipei, Taiwan)•invitedspeaker,Worldophthalmology Congress

PublicationsMaltaJB,SoonghK.diamonddrillsuperfi-cial keratectomy in the treatment of visually-significantanteriorcorneallesions.Arquivos Brasileiros de oftalmo 2008 [in press].

MaltaJB,BanittM,SoonghK.Free-float-ing cyst in anterior chamber after cataract surgery. Br J ophthalmol 2008 [in press].

Romero I, Paiato TP, Silva CB, Malta JB, Mimica LMG, Soong HK, Hida RY. Different application volumes of ethyl-cyanoacrylate tissue adhesive can change its antibacterial effects against ocular pathogens in vitro. curr eye Res 2008 [in press].

Soong HK, Malta JB, Mian SI, Juhasz T. Femtosecond laser-assisted lamellar kerato-plasty. Arquivos Brasileiros oftalmol 2008 [in press].

Banitt MR, Malta JB, Shtein RM, Soong HK. delayed-onsetisolatedcentraldescemet’smembrane blister detachment following phacoemulsification. J cat Refract Surg 2008 [in press].

Joshua D. Stein, M.D.

Awards/Honors/Leadership•EditorialBoard,evidence-Based ophthalmology•Judge,ophthalmology Times Resident Writer’saward

PublicationsStein JD, Ruiz D, Belsky S, et al. Longitudinal rates of postoperative adverse outcomes following glaucoma surgery among Medi-carebeneficiaries.ophthalmology 2008; 115:1109-16.

Stein JD, Newman-Casey P. Glaucoma associ-ated with corneal disorders. In: Tasman W, Jaeger EA, eds. Duane’s Clinical Ophthalmol-ogy, Foundations Vol. III, chap 54f, Philadel-phia, PA: Lippincott Williams & Wilkins 2008.

Stein JD, Herndon LW, Bond B, Challa P. Exposed Ex-PRESS tube shunts: case series and technique for tube shunt removal glaucoma 2008;16:704-6.

Stein JD, Ayyagari P, Sloan FA, Lee PP. Rates of glaucoma medication utilization among persons with primary open-angle glaucoma, 1992 to 2002. ophthalmology 2008 [Epub ahead of print].

Stein JD, Lee PP. Screening for glaucoma. In: Yanoff M, Duker JS, eds. ophthalmology, 3rd ed. St. Louis:Mosby 2008 [in press].

Stein JD, McDonnell PJ, Lee PP. Penetrating keratoplasty and glaucoma. In: Albert DM, Jakobiec FA, eds. Principles and Practice of ophthalmology, 3rd ed. Philadelphia: Saun-ders 2008 [in press].

Stein JD, Lee PP. Age and racial variation in the prevalence of open-angle glaucoma in the United States. In: Tombran-Tink J, Barn-stalde CJ, Shields MB, eds, Mechanisms of the glaucomas 2008 [in press].

Alan Sugar, M.D.


Awards/Honors/Leadership•invitedlecturer,internationalocular inflammationSociety,Paris,France•distinguishedalumnuslecturer,Ethical and Regulatory Basis of Research in Ophthalmology, Department of Ophthalmology & Visual Sciences, Washington University School of Medicine, St. Louis, MO

PublicationsGarcia DD, Farjo Q, Musch DC, Sugar A. The effect of prophylactic oral acyclovir after penetrating keratoplasty for herpes simplex keratitis. cornea 2007;26:930-4.

Patel SV, Sugar A. Dermatophytosis. In: Roy FH, Fraunfelder F, eds. current ocular Therapy, 6th ed. Philadelphia:WB Saunders, 2007.

Sugar A, Mintz R. Koch-Weeks bacillus. In: Roy FH, Fraunfelder F, eds. current ocular Therapy, 6th ed. Philadelphia:WB Saunders, 2007.

Cornea Donor Study Investigator Group (Sugar A, writing committee). The effect of donor age on corneal transplantation. Results of the Cornea Donor Study. ophthalmology 2008;115:620-6.

Cornea Donor Study Investigator Group (Sugar A, writing committee). Donor age and corneal endothelial cell loss 5 years after successful corneal transplantation: Specular Microscopy Ancillary Study results. ophthal-mology 2008;115:627-32.

Schallhorn SC, Farjo AA, Huang D, Boxer Wachler BS, Trattler WB, Tanzer DJ, Majmudar PA, Sugar A. Wavefront-guided LASIK for the correction of primary myopia and astigmatism. A report by the American Academy of Ophthalmology. ophthalmology 2008;115:1294-61.

Malta J, Ahmad FK, Mian SI, Sugar A. Cor-nealinflammatorydisorders.in:TrattlerW,Majmudar P, Luchs J, eds: cornea essentials. Thorofare, New Jersey:Slack Inc. 2008 [in press].



Alan Sugar, cont’d Ahmad OR, Mian SI, Sugar A. Future of keratoplasty. In: Brightbill FS, ed. corneal Surgery. St. Louis:CV Mosby 2008 [in press].

Anand Swaroop, Ph.D.


Awards/Honors/Leadership•EditorialBoard,investigative ophthalmology & Visual Science•EditorialreviewBoard,Molecular Vision•reviewer,TheWellcomeTrust,london,uK•reviewer,agencenationaledela recherche–BiotechnologyandBiological Sciences Research Council•29thannualdistinguishedFaculty Lecturership Award, University of Michigan Medical School •invitedlecturer,BhubaneswarlVPrasad Eye Institute, Bhubaneswar, India •invitedlecturer,Symposium,“Trendsin Human Genetics,” Toshali Sands, Puri, India•invitedlecturer,departmentof Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH•invitedplenarytalk,annualretreat, Comparative Medicine and Integrative Biology Graduate Program, Michigan State University, East Lansing, MI•invitedlecturer,SaveSightSunday Symposium, The Foundation Fighting Blindness North California Chapter•invitedlecturer,departmentofgenetics, Faculty of Biology, University of Barcelona•guestlecturer,hospitalesuniversitarios Virgin del Rocio, Seville, Spain

PublicationsRaven M, Oh E, Swaroop A, Reese B. Af-ferent control of horizontal cell morphology revealedbygeneticre-specificationofrodsand cones. J neurosci 2007;27:3540-7.

Trager EH, Khanna R, Marrs A, Siden L, Branham K, Swaroop A, Richards JR. Mad-eline 2.0 PDE: A new program for local and web-based pedigree drawing. Bioinformatics 2007;23:1854-6.

Cideciyan AV, Aleman TS, Jacobson SG, Khanna H, Sumaroka A, Aguirre GK, Schwartz SB, Windsor EAM, He S, Chang B, Stone EM, Swaroop A. Centrosomal-cili-ary gene CEP290/NPHP6 mutations result in blindness with unexpected sparing of photo-receptors and visual brain: implications for therapy of Leber congenital amaurosis. Hum Mutation 2007;28:1074-83.

Duncan JL, Zhang Y, Gandhi J, Nakanishi C, Othman M, Branham KEH, Swaroop A, Roorda A. High-resolution imaging with adaptive optics in patients with inherited retinal degeneration. invest ophthalmol Vis Sci 2007;48:3283-91.

Swain P, Kumar S, Patel D, Richong S, Oberoi P, Ghosh M, Swaroop A. Mutations associated with retinopathies alter mitogen-activated protein kinase-induced phosphory-lation of neural retina leucine-zipper. Mol Vis 2007;13:1114-20.

Swaroop A, Branham KEH, Chen W, Abecasis G. Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits [invited review]. Hum Mol genet 2007;16 Spec No 2:R174-82.

Kanda A, Chen W, Othman M, Branham KEH, Brooks M, Khanna R, He S, Lyons R, Abecasis GR, Swaroop A. A variant of mito-chondrial protein LOC387715, not HTRA1, is strongly associated with age-related macular degeneration. Proc natl Acad Sci uSA 2007;104:16227-32.

McEwen DP, Koenekoop RK, Khanna H, Jenkins PM, Lopez I, Swaroop A, Martens JR. Hypomorphic CEP290/NPHP6 mutations result in anosmia due to the loss of G-proteins in cilia of olfactory sensory neurons. Proc natl Acad Sci uSA 2007;104:15917-22.

Iannaccone A, Othman MI, Cantrell AD, Jennings BJ, Branham K, Swaroop A. Retinal phenotype of an x-linked pseudo-Usher syndrome in association with the G173R mu-tation in the RPGR gene. Adv exp Med Biol 2008;613:221-7.

He S, Parapuram SK, Hurd TW, Behnam B, Margolis B, Swaroop A, Khanna H. Retinitis pigmentosa GTPase regulator (RPGR) protein isoforms in mammalian retina: insights into x-linked retinitis pigmentosa and associated ciliopathies. Vision Res 2008;48:366-76.

Oh E, Cheng H, Hao H, Jia L, Khan NW, Swaroop A. Rod differentiation factor NRL activates the expression of nuclear receptor NR2E3 to suppress the development of cone photoreceptors. Brain Res 2008 [in press].

Walia S, Fishman GA, Swaroop A, Branham KEH, Lindeman M, Othman M, Weleber RG. Discordant phenotypes in fraternal twins hav-ing identical mutation in exon ORF15 of the RPGR gene. Arch ophthalmol 2008;126:379-84.

FeathersK,lyubarskya,Khann,TeofiloK,Swaroop A, Williams D, Pugh E, Thompson D. nrl-knockoutmicedeficientinrpe65fail to synthesize 11-cis retinal and cone outer segments. invest ophthalmol Vis Sci 2008;49:1126-35.

Siffroi-Fernandez S, Felder-Schmittbuhl M, Khanna H, Swaroop A, Hicks D. FGF19 exhibits neuroprotective effects on adult mammalian photoreceptors in vitro. invest ophthalmol Vis Sci 2008;49:1694-1704.

Kandaa,abecasisg,Swaroopa.inflamma-tion in the pathogenesis of age-related macu-lar degeneration. [editorial]. Br J ophthalmol 2008;92:448-50.

Debra A. Thompson, Ph.D.


PublicationsFeathersKl,lyubarskyal,KhannW,TeofiloK, Swaroop A, Williams DS, Pugh EN Jr, Thompson DA. nrl-knockoutmicedeficientin Rpe65 fail to synthesize 11-cis retinal and cone outer segments. invest ophthalmol Vis Sci 2008;49:1126-35.

Susan S. Thoms, M.D.


Outreach•Trainingstudentsforglobaloutreach; a medical student worked in rural Mongolia and an undergraduate student worked in Ghana through Fight for Sight.

Jonathan D. Trobe, M.D.

Awards/Honors/Leadership•Best doctors in America•VisitingProfessor,longwoodProgramin Neurology, Harvard Medical School•VisitingProfessor,departmentof Neurology, Massachusetts General Hospital, Harvard Medical School•henryVandykelecturer,departmentof Ophthalmology, Louisiana State University•KeynoteSpeaker,asianneuro- Ophthalmology Society, Taipei•KeynoteSpeaker,germanophthalmology Congress, Berlin•Visitinglecturer,BirminghamEyehospital, Birmingham, England•Editor-in-chief,Journal of neuro- ophthalmology

PublicationsChong DY, Comer GM, Trobe JD. Optic disc edema, cystoid macular edema, and elevated vascular endothelial growth factor in a patient with POEMS syndrome. J neuro- ophthalmol 2007;27:180-3.

Margolin E, Gujar SK, Trobe JD. Isolated cortical visual loss with subtle brain MRI abnormalities in a case of hypoxic-ischemic encephalopathy. J neuro-ophthalmol 2007;27:292-6.

Margolin E, Flint A, Trobe JD. High-titer col-lapsing response-mediating protein-associated (CRMP-5) paraneoplastic optic neuropathy and vitritis as the only clinical manifestations in a patient with small cell lung carcinoma. J neuro-ophthalmol 2008;28:17-22.



Hassan KA, Kalemkerian GP, Trobe JD. Long-term survival in paraneoplastic opsoc-lonus-myoclonus syndrome associated with small cell lung cancer. J neuro-ophthalmol 2008;28:27-30.

Pribila JT, Ronan SM, Trobe JD. Multiple in-tracranial meningiomas causing papilledema and visual loss in a patient with nevoid basal cell carcinoma syndrome. J neuro-ophthal-mol 2008;28:41-6.

Trobe JD. Rapid diagnosis in neuro-ophthal-mology. Edinburgh, Scotland:Elsevier Books, 2008.

Andrew K. Vine, M.D.



PublicationsThe PKC-DMES Study Group. Effect of Ruboxistaurin in patients with diabetic macular edema. Arch ophthalmol 2007;125: 318-24.

Demirci H, Vine AK, Elner VM. Choroidal metastasis from submandibular salivary gland adenoid cystic carcinoma. ophthalmic Surg lasers imaging 2008;39:57-9.

Jennifer S. Weizer, M.D.

Awards/Honors/Leadership•director,Fellowshipprogram,university of Michigan W.K. Kellogg Eye Center•invitedlecturer,americanglaucoma Society, Washington, DC

PublicationsWeizer JS, Asrani S, Stinnett SS, Herndon LW. The clinical utility of dynamic contour tonometry and ocular pulse amplitude. J glaucoma 2007;16:700-3.

Weizer JS, Lee PP. Primary open-angle glau-coma. Atlas of glaucoma, 2nd ed. informa Healthcare, 2007 [in press]

Weizer JS. Acute angle-closure glaucoma. up-to-date 2008 [in press].

Rebecca A. Wu, M.D.

PublicationsWu RA, Best RM, Musch DC, Johnson MW. Surgical removal of subfoveal choroidal neovascular membranes in older patients without age-related macular degeneration. clin ophthalmol 2007;1:157-65.

Dongli Yang, M.D., Ph.D.

PublicationsYang D, Elner SG, Bian ZM, Till GO, Petty hr,ElnerVM.Pro-inflammatorycytokinesincrease reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells. exp eye Res 2007;85:462-72.

Yang D, Swaminathan A, Zhang x, Hughes BA. Expression of Kir7.1 and a novel Kir7.1 splice variant in native human retinal pigment epithelium. exp eye Res 2008;86:81-91.

Yang D, Zhang x, Hughes BA. Expression of inwardly rectifying potassium channel sub-units in native human retinal pigment epithelium. exp eye Res 2008 [in press].


David N. Zacks, M.D., Ph.D.


Awards/Honors/Leadership•SectionModerator:BasicScienceSection, 31st Macula Society annual meeting•co-director,80thannualSpring Conference, University of Michigan Department of Ophthalmology and Visual Sciences•honoraryco-chair,FoundationFighting Blindness Eastern Michigan Vision-Walk •Keynotespeaker,ViSionS2008•guestfaculty,3rdannualheed Ophthalmologic Foundation Faculty–residentretreat•SectionModerator:retinaldetachment– A Symposium in Honor of Charles L. Schepens, MD, 40th Annual Retina Society Meeting

PublicationsZacks DN, Boehlke C, Richards AL, Zheng QD. Photoreceptor neuroprotection: the role of the FAS signaling pathway. Arch ophthal-mol 2007;125:1389-95.

Leveque TK, Yu L, Musch DC, Chervin RC, Zacks DN. Central serous chorioretinopathy and risk for obstructive sleep apnea. Sleep and Breathing 2007;11:253-7.

Hall EF, Scott GR, Musch DC, Zacks DN. Adjunctive intravitreal dexamethasone in the treatment of acute endophthalmitis follow-ing cataract surgery. clinical ophthalmol 2008;2:139-45.

Chong DY, Boehlke CS, Zheng QD, Zhang L, Han Y, Zacks DN. Interleukin-6 as a photo-receptor neuroprotectant in an experimental model of retinal detachment. invest ophthal-mol Vis Sci 2008;49:3193-3200.

Grabe H, Zacks DN. Seat belt retinopathy: a case of Purtscher-like retinopathy following a motor vehicle accident. Retinal cases and Brief Reports 2008 [in press].

Conrad PW, Zacks DN, Johnson MW. Intra-vitrealbevacizumabhasinitialclinicalbenefitlasting eight weeks in eyes with neovascular age-related macular degeneration. clinical ophthalmol 2008 [in press].



Faculty Name Source ID Project Title

R. Ayyagari, Ph.D. NIH R01-EY13198-06 Macular Degeneration: Genetics of 4 Distinct Phenotypes R01-EY13198-06S1 FFB Center for the Study of Retinal Degenerative Diseases RPB International Research Scholar Award

T. Bergstrom, M.D. NIH/Clinical Trial U10-EY10439-15 Ocular Hypertension Treatment Study (OHTS) Coordinating Center: Washington University

M. Del Monte, M.D. NIH/Clinical Trial U10-EY11751 Pediatric Eye Disease Investigator Group Multiple Projects, Coordinating Center: Jaeb Pfizerophthalmicsresearch PhaseiopenlabelStudyoflatanoprostinPediatric and Adult Glaucoma Patients J. Demb, Ph.D. NIH R01-EY14454-04 Functional Circuitry of Visual Adaptation RPB Career Development Award Sloan Foundation Sloan Research Fellowship

S. Elner, M.D. NIH/Clinical Trial U10-EY14660 Multicenter Uveitis Steroid Treatment (MUST) Trial Coordinating Center: Johns Hopkins University

V. Elner, M.D., Ph.D. NIH R01-EY09441-13 RPE-MΦ Binding: Ca++ & O2- Dependent AMD Responses rPB SeniorScientificinvestigatoraward U-M Medical School Translational Research Initiatives Program Grant Michigan Universities Prototype Development ETCF Grant Commercialization Initiative

P. Gage, Ph.D. NIH R01-EY14126-05 Pitx 2: Molecular Mechanisms in Eye Development and Disease D. Green, Ph.D. NIH R01-EY10084-06 Clinical and Molecular Analysis of Oregon Eye Disease Subcontract with De-Ann Pillers, M.D., Ph.D., Oregon Health and Science University

J. Heckenlively, M.D. NIH R01-EY07758-20 Mouse Models of Human Hereditary Eye Diseases NIH R01-EY16862-03 Genetic Variations in Age-Related Macular Degenerations FFB Center for the Study of Retinal Degenerative Diseases FFB Consortium Treatment Grant: Assessment of Therapies FFB Resource Facility for x-linked Retinitis Pigmentosa and Age-Related Macular Degeneration Neurotech USA Phase II/III Study of Encapsulated Human Cell Implants Releasing CNTF for Participants with Retinitis Pigmentosa Sramek Foundation Interactive and Integrated Genetic Databases for the Study of Age-Related Macular Degeneration

GRANTS



GRANTS

P. Hitchcock, Ph.D. NIH R01-EY07060-19 Neuronal Development, Injury and Regeneration in Retina nih r01-EY11115-11 MolecularMechanismsofretina-SpecificgeneExpression NIH T32-EY17878-06 Early Stage Training in the Neurosciences FFB–canada identificationandFunctionofMolecularcuesfor Photoreceptor Regeneration in the Vertebrate Retina rPB SeniorScientificinvestigatoraward B. Hughes, Ph.D. NIH P30-EY07003-22 Core Center for Vision Research (four core modules) NIH R01-EY08850-17 Ion Conductances in the Retinal Pigment Epithelium RPB Lew R. Wasserman Award

M. Johnson, M.D. NIH/Clinical Trial N01-EY12113 Preservative-Free Triamcinolone Acetonide as an Adjunct to Photodynamic Therapy for Age-Related Macular Degeneration, Coordinating Center: Emmes NIH/Clinical Trial U10-EY14351 Standard Care Versus Corticosteroid for Retinal Vein Occlusion (SCORE) Study, Coordinating Center: University of Wisconsin Genentech, Inc./Clinical Trial Ranibizumab in Naïve and Previously Treated Subjects with Choroidal Neovascularization Secondary to Age-Related Macular Degeneration GlaxoSmithKline/Clinical Trial Study to Investigate Pharmacodynamics, Safety, and Systemic Pharmacokinetics of Pazopanib Eye Drops regeneronPharmaceutical/clinicalTrial PhaseiiiStudyofEfficacy,Safety,andTolerabilityof Repeated Doses of Intravitreal VEGF Trap in Subjects with Neovascular AMD a.Kahana,M.d.,Ph.d.nih K08-EY018689-01 ZebrafishModelforStudyingorbitaldevelopment and Disease

H. Khanna, Ph.D. NIH R01-EY07961-18 x-Linked Retinitis Pigmentosa FFB Center for the Study of Retinal Degenerative Diseases FFB Consortium Treatment Grant: Transplantation of Photoreceptor Precursors Midwest Eye-Banks Elucidation of Ciliary Dysfunction in CEP290/NPHP6 T. Leveque, M.D. NIH M01-RR00042 Prevalence of Obstructive Sleep Apnea in Patients with centralSerouschorioretinopathy–fundedbya Clinical and Translational Science Award

E. Levin, M.D. NIH/Clinical Trial U10-EY11751 Pediatric Eye Disease Investigator Group Multiple Projects, Coordinating Center: Jaeb

P. Lichter, M.D. RPB Unrestricted Grant VisionCare Ophthalmic Technologies/ VisionCare Ophthalmic Technologies Implantable Clinical Trial Miniature Telescope for Central Vision Impairment Associated with Age-Related Macular Degeneration and Other Maculopathies



M. Lipson, O.D. EyeVis L.L.C. Stabilizing Myopia by Accelerated Reshaping Technique S. Mian, M.D. NIH R01-EY14163-01 Femtosecond Laser Posterior Lamellar Keratoplasty Subcontract with Tibor Juhasz, Ph.D., University of California - Irvine Fight for Sight and MICHR Femtosecond Laser-Assisted Keratoplasty S.Moroi,M.d.,Ph.d. Pfizer/clinicalTrial XalacomgivenintheEvening,XalatanintheEvening, and Timolol S in the Morning for Open-angle Glaucoma or Ocular Hypertension U-M Medical School Improving Trabeculectomy Outcome with Human Amniotic Membrane

D. Musch, Ph.D., M.P.H. Midwest Eye-Banks Long-Term Follow-up of Keratoconus Recipients

C. Nelson, M.D. Midwest Eye-Banks Genetics of Anophthalmia in a 3-Generation Pedigree Midwest Eye-Banks Medical Student Fellowship

H. Petty, Ph.D. NIH N01-HD-2-3342 Services in Support of the Perinatology Research Branch Subcontract with Wayne State University NIH R01-CA74120-10 Signaling Dynamics of Leukocyte-Tumor Cell Interactions NIH R01-AI60983-02 Lipid Raft Microdomains in Neutrophil Function Subcontract, Robert Sitrin, M.D., U-M Medical School arthritisFoundation novelanti-inflammatoryPeptidesBaseduponFcriia Midwest Eye -Banks Time-Gated Single Molecule Fluorescence Imaging U-M Medical School Translational Research Initiatives Program Grant Wilson Foundation Signal Waves in Tumor Cell Killing: A Systems Biology Approach in Oncology D. Puro, M.D., Ph.D. NIH R01-EY12507-09 Physiology of Retinal Pericytes NIH T32-EY013934 Vision Research Training Program rPB SeniorScientificinvestigatoraward

J. Richards, Ph.D. NIH R01-EY11671-08 Molecular Genetics of Glaucoma and Related Disorders AHAF Genetic Risk Factors and Glaucoma Outcomes Fight for Sight Sequence Variants in CLCN3 and the Associated Risk of Glaucoma — Student Fellowship

R. Shtein, M.D. NIH K23-EY017885-01 Neovascularization Patterns in Corneal Graft Rejection MICHR Pathogenesis of Idiopathic Dry Eye

h.KazSoong,M.d. nih r01-EY014456 FemtosecondlaserEnhancedaqueousoutflowFacility Subcontract with Tibor Juhasz, Ph.D., University of California - Irvine

GRANTS



GRANTS

A. Sugar, M.D. NIH/Clinical Trial U10-EY12358 Cornea Donor Study, Coordinating Center: Jaeb NIH/Clinical Trial R01-EY016482 A Multi-Center Study to Map Genes for Fuchs Dystrophy Coordinating Center: Case Western Reserve University Lux Biosciences, Inc. A Randomized Dose-Ranging Study to Assess the EfficacyandSafetyoflX201forPreventionofcorneal Allograft Rejection Episodes and Graft Failure following Penetrating Keratoplasty

A. Swaroop, Ph.D. NIH P50-DK39255-19 Function of Ciliary Protein RPGR in Renal Epithelial Cells: Possible Implications for Renal-Retinal Disease Subcontract, Roger Wiggins, M.D., U-M Medical School NSF DBI 0543272 Integrated Biological Sequence Data Management Subcontract, Alfred Hero, Ph.D., University of Michigan Fight for Sight Screen for Human Mutations in RD11, the Gene Responsible for the rd11 Mouse Retinopathy — Student Fellowship Fight for Sight Novel Leucine-Rich Proteins — Student Fellowship Thompson Foundation Macular Degeneration Research Project D. Thompson, Ph.D. FFB Center for the Study of Retinal Degenerative Diseases FFB Consortium Treatment Grant: Small Molecular Interventions

A. Vine, M.D. LMRI/Clinical Trial A Natural History Study of Macular Telangiectasia — The MacTel Study

D. Zacks, M.D., Ph.D. NIH K08-EY14705-05 Apoptosis in Retinal Detachments FFB Center for the Study of Retinal Degenerative Diseases FFB Consortium Treatment Grant: Transplantation of Photoreceptor Precursors IRRF Control of Photoreceptor Apoptosis Midwest Eye-Banks Intravitreal Linezolid in Rabbits: an Electrophysiologic and Histopathologic Analysis RPB Career Development Award

Source AbbreviationsAHAF – American Health Assistance Foundation MicHR – Michigan institute for clinical and Health ResearchFFB – Foundation Fighting Blindness niH – national institutes of HealthiRRF – international Retinal Research Foundation nSF – national Science FoundationlMRi – lowy Medical Research institute RPB – Research to Prevent Blindness

Faculty of the Department of Ophthalmology and Visual Sciences 2007– 2008

Paul R. Lichter, C

hair

James L. Adam

s

John R. Heckenlivel

yRoni M. Shtei

n

Steven M. Arch

er

Robert C. Aren

ds

Radha Ayyagar

i

Terry J. Bergstrom

Donald S. Bese

r

Grant M. Comer

Theresa M. Coon

ey

Wayne T. Cornbla

th Sherry H. Day

Monte A. Del M

onte Jonathan B. Demb M

aya Eibschitz

Jerome I. Finkels

tein

Susan G. ElnerVictor M. Elner Carlton J. Foste

r Bartley R. Frueh

Philip J. Gage

Jill E. Green

Peter F. Hitchco

ck

Michael Smith-Whe

eloc

k

H

oward R. Pett

y

Bret A. HughesIda L. Iacobucc

i Diane M. Jacobi

Mark W. Johnso

n Alon Kahana

Harjeet Kaur

James G. Knag

gsH

elios T. Leung

Thellea K. Leveq

ue

Erika M. Levin

Michael J. Lipso

n Shahzad I. Mian

Sayoko E. Moroi David C. Musch

Christine C. Nels

on

Julia E. Richards

Bruce A. Furr

Donna M. Wick

er

Gary S. Sandall

Stephen J. Sax

e H. Kaz Soong

Joshua D. Stei

n Alan Sugar

Anand Swaroop

Bradley W. Taylor

Debra A. Thomps

on Susan S. Thoms

Jonathan D. Trobe Andrew K. Vine

Jennifer S. Weiz

erAdrienne L. W

est David N. Zack

sRebecca A. W

u

Frank W. Rozsa

Dongli Yang

H

emant KhannaN

aheed W. Khan

Donald G. Puro

Daniel G. Gree

n

Executive Officers of the University of Michigan Health System

Robert P. Kelch, M.D. executive Vice President for Medical Affairs Douglas L. Strong, M.B.A. director and ceo, university of Michigan Hospitals and Health centers James O. Woolliscroft, M.D. dean, university of Michigan Medical School

The Regents of the University of Michigan Julia Donovan Darlow, Ann Arbor; Laurence B. Deitch, Bingham Farms;Olivia P. Maynard, Goodrich; Rebecca McGowan, Ann Arbor;Andrea Fischer Newman, Ann Arbor; Andrew C. Richner, Grosse Pointe Park;S. Martin Taylor, Grosse Pointe Farms; Katherine E. White, Ann Arbor;Mary Sue Coleman, Ph.D., ex officio

For additional copies of this report,

please contact us at:

University of Michigan Department of Ophthalmology and Visual SciencesW.K. Kellogg Eye Center1000 Wall StreetAnn Arbor, Michigan 48105

734.647.5586www.kellogg.umich.edu

Editors: Betsy nisbet, Randy Wallach

Writers and Editorial Assistants: Aimee Bergquist, lisa Burkhart, MargaretAnn cross

Design: david Murrel

Photographers: Scott galvin, lin Jones, Scott Soderberg, Martin Vloet: u-M Photo Services; Robert Prusak: u-M department of ophthalmology and Visual Sciences

Portrait of William carls (p. 24) painted by Robert Maniscalco. Photograph courtesy of Children’s Hospital of Michigan.

We are pleased to be ranked among the top hospitals in the nation for ophthalmology in the 2008 u.S.news & World Report survey.

OUR MISSIONTO SOLVE THE PUZZLES OF BLINDING EYE DISEASE,

TO IMPROVE THE QUALITY OF LIFE FOR OUR PATIENTS,

AND TO TEACH THE NExT GENERATION OF VISION

SCIENTISTS AND CLINICIANS.

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