PHS 398 (Rev. 08/12) Face Page Form Page 1

Form Approved Through 8/31/2015 OMB No. 0925-0001

Department of Health and Human ServicesPublic Health Services

Grant ApplicationDo not exceed character length restrictions indicated.

LEAVE BLANK—FOR PHS USE ONLY.Type Activity NumberReview Group Formerly

Council/Board (Month, Year) Date Received

1. TITLE OF PROJECT (Do not exceed 81 characters, including spaces and punctuation.)

2. RESPONSE TO SPECIFIC REQUEST FOR APPLICATIONS OR PROGRAM ANNOUNCEMENT OR SOLICITATION NO YES(If “Yes,” state number and title)

Number: Title:

3. PROGRAM DIRECTOR/PRINCIPAL INVESTIGATOR

3a. NAME (Last, first, middle) 3b. DEGREE(S) 3h. eRA Commons User Name

3c. POSITION TITLE 3d. MAILING ADDRESS (Street, city, state, zip code)

E-MAIL ADDRESS:

3e. DEPARTMENT, SERVICE, LABORATORY, OR EQUIVALENT

3f. MAJOR SUBDIVISION

3g. TELEPHONE AND FAX (Area code, number and extension)

TEL: FAX:

4. HUMAN SUBJECTS RESEARCH

No Yes

4a. Research Exempt If “Yes,” Exemption No.

No Yes

4b. Federal-Wide Assurance No. 4c. Clinical Trial

No Yes

4d. NIH-defined Phase III Clinical Trial

No Yes

5. VERTEBRATE ANIMALS No Yes 5a. Animal Welfare Assurance No.

6. DATES OF PROPOSED PERIOD OF SUPPORT (month, day, year—MM/DD/YY)

7. COSTS REQUESTED FOR INITIAL BUDGET PERIOD

8. COSTS REQUESTED FOR PROPOSED PERIOD OF SUPPORT

From Through 7a. Direct Costs ($)

29,6307b. Total Costs ($)

38,5198a. Direct Costs ($)

71,1178b. Total Costs ($)

92,4529. APPLICANT ORGANIZATION Name

Address

10. TYPE OF ORGANIZATION

Public: Federal State Local

Private: Private Nonprofit

For-profit: General Small BusinessWoman-owned Socially and Economically Disadvantaged

11. ENTITY IDENTIFICATION NUMBER

DUNS NO. Cong. District

12. ADMINISTRATIVE OFFICIAL TO BE NOTIFIED IF AWARD IS MADE Name

Title

Address

Tel: FAX:

E-Mail:

13. OFFICIAL SIGNING FOR APPLICANT ORGANIZATION Name

Title

Address

Tel: FAX:

E-Mail:

14. APPLICANT ORGANIZATION CERTIFICATION AND ACCEPTANCE: I certify that the statements herein are true, complete and accurate to the best of my knowledge, and accept the obligation to comply with Public Health Services terms and conditions if a grant is awarded as a result of this application. I am aware that any false, fictitious, or fraudulent statements or claims may subject me to criminal, civil, or administrative penalties.

SIGNATURE OF OFFICIAL NAMED IN 13.(In ink. “Per” signature not acceptable.)

DATE

Program Director/Principal Investigator (Last, First, Middle): Hunt, Casey Morgan

DETAILED BUDGET FOR INITIAL BUDGET PERIOD DIRECT COSTS ONLY

FROM THROUGH

List PERSONNEL (Applicant organization only)Use Cal, Acad, or Summer to Enter Months Devoted to ProjectEnter Dollar Amounts Requested (omit cents) for Salary Requested and Fringe Benefits

NAMEROLE ON PROJECT

Cal. Mnths

Acad. Mnths

SummerMnths

INST.BASE SALARY

SALARY REQUESTED

FRINGE BENEFITS TOTAL

Hunt, Casey MorganHPTN

Scholar 2.4 $100,000 $19,800 $3,750 $23,550

SUBTOTALS $19,800 $3,750 $23,550

CONSULTANT COSTS

EQUIPMENT (Itemize)

SUPPLIES (Itemize by category)

TRAVEL

(1) HPTN Meeting in Washington, DC (2) Mid-Year Retreat (3) Mentor Meetings $6,080INPATIENT CARE COSTS

OUTPATIENT CARE COSTSALTERATIONS AND RENOVATIONS (Itemize by category)

OTHER EXPENSES (Itemize by category)

CONSORTIUM/CONTRACTUAL COSTS DIRECT COSTS

SUBTOTAL DIRECT COSTS FOR INITIAL BUDGET PERIOD (Item 7a, Face Page) $ 29,630CONSORTIUM/CONTRACTUAL COSTS FACILITIES AND ADMINISTRATIVE COSTS

TOTAL DIRECT COSTS FOR INITIAL BUDGET PERIOD $ 29,630PHS 398 (Rev. 08/12 Approved Through 8/31/2015) OMB No. 0925-0001

04/01/2017 11/30/2017

Page Form Page 4

Program Director/Principal Investigator (Last, First, Middle): Hunt, Casey Morgan

DETAILED BUDGET FOR SECOND FUNDING BUDGET PERIOD DIRECT COSTS ONLY

FROM THROUGH

List PERSONNEL (Applicant organization only)Use Cal, Acad, or Summer to Enter Months Devoted to ProjectEnter Dollar Amounts Requested (omit cents) for Salary Requested and Fringe Benefits

NAMEROLE ON PROJECT

Cal. Mnths

Acad. Mnths

SummerMnths

INST.BASE SALARY

SALARY REQUESTED

FRINGE BENEFITS TOTAL

Hunt, Casey MorganHPTN

Scholar 3 $100,000 $25,000 $7,500 $32,500

SUBTOTALS $25,000 $7,500 $32,500

CONSULTANT COSTS

EQUIPMENT (Itemize)

SUPPLIES (Itemize by category)

TRAVEL

(1) HPTN Meeting in Washington, DC (2) HIV/AIDS Nat’l Meeting (3) Mentor MMeetings

$8,987INPATIENT CARE COSTS

OUTPATIENT CARE COSTSALTERATIONS AND RENOVATIONS (Itemize by category)

OTHER EXPENSES (Itemize by category)

CONSORTIUM/CONTRACTUAL COSTS DIRECT COSTS

SUBTOTAL DIRECT COSTS FOR INITIAL BUDGET PERIOD (Item 7a, Face Page) $ 41,487CONSORTIUM/CONTRACTUAL COSTS FACILITIES AND ADMINISTRATIVE COSTS

12/1/2017 09/30/2018

TOTAL DIRECT COSTS FOR INITIAL BUDGET PERIOD $ 41,487PHS 398 (Rev. 08/12 Approved Through 8/31/2015) OMB No. 0925-0001

Page Form Page 4

OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) Page Continuation Format Page

Program Director/Principal Investigator (Last, First, Middle): Hunt, Casey Morgan

BUDGET J U STIFICATION – Initial Period of Performance (1 April-30 Nov 2017)

PERSONNEL

HPTN Scholar Salary Supplement: The HPTN Scholar salary supplement requests funding to cover

We request % Salary Supplement for 8 months: $

TRA V EL Travel Expenses: We are requesting travel funds for travels to HPTN Scholars related meetings,conferences, and visiting mentorship with ( Your HPTN Men t or ) at (Institution). Travel funds requested as outlined below include round trip airfare, hotel, meals, ground transportation, and travel-related incidentals. We request a travel budget for attendance to the meetings for the initial period of performance: $ _________________

2017 HPTN ANNUAL MEETINGS (April 2017, 1 MEETING, 4 DAYS): $ Attendance to this annual HPTN meeting is a requirement of the HPTN Scholars Program. Estimates are based on travel to Washington, DC which is the typical location of this meeting.

Travel from to Washington DC (RT): $ Hotel: $ / day x 4 days = $ Meals: $ /day x 4 days = $ Ground transportation: $ Travel costs incidentals: $

HPTN SCHOLARS RETREAT (1 MEETING, 3 DAYS): $

Please be very detailed and thorough. This personnel justification should utilize at least half this page.

OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) Page Continuation Format Page

Attendance to this retreat is a requirement of the HPTN Scholars Program. Estimates are based on travel to Seattle, WA which is the typical location of this meeting.

Travel from to _ (RT): $ Hotel: $ / day x 3 days = $ Meals: $ /day x 3 days = $ Ground transportation: $ Travel costs incidentals: $

Travel to Mentor’s site: $___________ Travel from ___________ to __________ (RT): $______ Hotel: $______/ day x 3 days = $________ Meals $______/ day x 3 days = $________ Ground transportation: $________ Travel costs incidentals: $_______

Additional relevant conference (IAS, USCA, etc.): $ Attendance to the conference in (month) _______ (year) ______

Travel from to _ (RT): $ Hotel: $ / day x 3 days = $ Meals: $ /day x 3 days = $ Ground transportation: $ Travel costs incidentals: $

OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) Page Continuation Format Page

BUDGET J U STIFICATION – Second Period of Performance (1 Dec 2017-30 Sept 2018)

PERSONNEL

HPTN Scholar Salary Supplement: The HPTN Scholar salary supplement requests funding to cover

We request % Salary Supplement for 10 months: $

TRA V EL Travel Expenses: We are requesting travel funds for travels to HPTN Scholars related meetings,conferences, and visiting mentorship with ( Your HPTN Men t or ) at (Institution). Travel funds requested as outlined below include round trip airfare, hotel, meals, ground transportation, and travel-related incidentals. We request a travel budget for attendance to the meetings for the second period of performance: $ _________________

2018 HPTN ANNUAL MEETING (1 MEETING, 4 DAYS): $ .Attendance to this annual HPTN meeting is a requirement of the HPTN Scholars Program. Estimates are based on travel to Washington, DC which is the typical location of this meeting.

Travel from to Washington DC (RT): $ Hotel: $ / day x 4 days = $ Meals: $ /day x 4 days = $ Ground transportation: $ Travel costs incidentals: $ _

Travel to Mentor’s site: $___________

Please be very detailed and thorough. This personnel justification should utilize at least half this page.

OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) Page Continuation Format Page

Travel from ___________ to __________ (RT): $______ Hotel: $______/ day x 3 days = $________ Meals $______/ day x 3 days = $________ Ground transportation: $________ Travel costs incidentals: $_______

Additional relevant conference – if not attended in period 1 (IAS, USCA, etc.): $ Attendance to the conference in (month) _______ (year) ______.

Travel from to _ (RT): $ Hotel: $ / day x 3 days = $ Meals: $ /day x 3 days = $ Ground transportation: $ Travel costs incidentals: $

Program Director/Principal Investigator (Last, First, Middle):

BIOGRAPHICAL SKETCHProvide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.

Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE

eRA COMMONS USER NAME (credential, e.g., agency login)

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)

INSTITUTION AND LOCATION DEGREE(if applicable) MM/YY FIELD OF STUDY

NOTE: The Biographical Sketch may not exceed four pages. Follow the formats and instructions below.

1. Personal StatementBriefly describe why your experience and qualifications make you particularly well-suited for your role (e.g., PD/PI, mentor, participating faculty) in the project that is the subject of the application. Within this section you may, if you choose, briefly describe factors such as family care responsibilities, illness, disability, and active duty military service that may have affected your scientific advancement or productivity.

B. Positions and HonorsList in chronological order previous positions, concluding with the present position. List any honors. Include present membership on any Federal Government public advisory committee.

C. Selected Peer-reviewed PublicationsNIH encourages applicants to limit the list of selected peer-reviewed publications or manuscripts in press to no more than 15. Do not include manuscripts submitted or in preparation. The individual may choose to include selected publications based on recency, importance to the field, and/or relevance to the proposed research. When citing articles that fall under the Public Access Policy, were authored or co-authored by the applicant and arose from NIH support, provide the NIH Manuscript Submission reference number (e.g., NIHMS97531) or the PubMed Central (PMC) reference number (e.g., PMCID234567) for each article. If the PMCID is not yet available because the Journal submits articles directly to PMC on behalf of their authors, indicate “PMCJournal – In Process.” A list of these Journals is posted at: http://publicaccess . nih. g ov/submit_process_jou r nals.ht m . Citations that are not covered by the Public Access Policy, but are publicly available in a free, online format may include URLs or PMCID numbers along with the full reference (note that copies of publicly available publications are not accepted as appendix material.)

D. Research SupportList both selected ongoing and completed research projects for the past three years (Federal or non-Federally- supported). Begin with the projects that are most relevant to the research proposed in the application. Briefly indicate the overall goals of the projects and responsibilities of the key person identified on the Biographical Sketch. Do not include number of person months or direct costs.

OMB No. 0925-0001/0002 (Rev. 8/12 Approved Through 8/31/2015) Page Biographical Sketch Format Page

Program Director/Principal Investigator (Last, First, Middle): Hunt, Morgan C.

BIOGRAPHICAL SKETCHProvide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.

Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAMEHunt, Morgan CaseyeRA COMMONS USER NAME (credential, e.g., agency login)huntmc

POSITION TITLEAssociate Professor of Psychology

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)

INSTITUTION AND LOCATION DEGREE(if applicable) MM/YY FIELD OF STUDY

University of California, Berkeley

University of Vermont

University of California, Berkeley

B.S.

Ph.D.

Postdoctoral

05/90

05/96

08/98

Psychology

ExperimentalPsychology

Public Health andEpidemiology

1. Personal StatementThe goal of the proposed research is to investigate the interaction between drug abuse and normal aging processes. Specifically, we plan to measure changes in cognitive ability and mental and physical health across a five-year period in a group of older drug users and matched controls. I have the expertise, leadership and motivation necessary to successfully carry out the proposed work. I have a broad background in psychology, with specific training and expertise in key research areas for this application. As a postdoctoral fellow at Berkeley, I carried out ethnographic and survey research and secondary data analysis on psychological aspects of drug addiction. At the Division of Intramural Research at the National Institute onDrug Abuse (NIDA), I expanded my research to include neuropsychological changes associated with addiction. As PI or co-Investigator on several university- and NIH-funded grants, I laid the groundwork for the proposed research by developing effective measures of disability, depression, and other psychosocial factors relevant to the aging substance abuser, and by establishing strong ties with community providers that will make it possible to recruit and track participants over time. In addition, I successfully administered the projects (e.g. staffing, research protections, budget), collaborated with other researchers, and produced several peer-reviewed publications from each project. As a result of these previous experiences, I am aware of the importance of frequent communication among project members and of constructing a realistic research plan, timeline, and budget. The current application builds logically on my prior work, and I have chosen co-investigators (Drs. Gryczynski and Newlin) who provide additional expertise in cognition, gerontology and geriatrics. During 2005-2006 my career was disrupted due to family obligations. However, upon returning to the field I immediately resumed my research projects and collaborations and successfully competed for NIH support. In summary, I have a demonstrated record of accomplished and productive research projects in an area of high relevance for our aging population, and my expertise and experience have prepared me to lead the proposed project.

B. Positions and Honors

Positions and Empl o y ment 1998-2000 Fellow, Division of Intramural Research, National Institute of Drug Abuse, Bethesda, MD2000-2002 Lecturer, Department of Psychology, Middlebury College, Middlebury, VT2001- Consultant, Coastal Psychological Services, San Francisco, CA

OMB No. 0925-0001/0002 (Rev. 8/12 Approved Through 8/31/2015) Page Biographical Sketch Format Page

OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) Page Biographical Sketch Format Page

Program Director/Principal Investigator (Last, First, Middle): Hunt, Morgan C.

2002-2005 Assistant Professor, Department of Psychology, Washington University, St. Louis, MO2007- Associate Professor, Department of Psychology, Washington University, St. Louis, MO

Other Exp e rience and Professional Member s hips 1995- Member, American Psychological Association1998- Member, Gerontological Society of America1998- Member, American Geriatrics Society2000- Associate Editor, Psychology and Aging2003- Board of Advisors, Senior Services of Eastern Missouri2003-05 NIH Peer Review Committee: Psychobiology of Aging, ad hoc reviewer2007-11 NIH Risk, Adult Addictions Study Section, member

Honors2003 Outstanding Young Faculty Award, Washington University, St. Louis, MO2004 Excellence in Teaching, Washington University, St. Louis, MO2009 Award for Best in Interdisciplinary Ethnography, International Ethnographic Society

C. Selected Peer-reviewed Publications (Selected from 42 peer-reviewed publications)

Most relev a nt to the current application 1. Merryle, R.J. & Hunt, M.C. (2004). Independent living, physical disability and substance abuse among the

elderly. Psychology and Aging, 23(4), 10-22.2. Hunt, M.C., Jensen, J.L. & Crenshaw, W. (2007). Substance abuse and mental health among community-

dwelling elderly. International Journal of Geriatric Psychiatry, 24(9), 1124-1135.3. Hunt, M.C., Wiechelt, S.A. & Merryle, R. (2008). Predicting the substance-abuse treatment needs of an

aging population. American Journal of Public Health, 45(2), 236-245. PMCID: PMC91622924. Hunt, M.C., Newlin, D.B. & Fishbein, D. (2009). Brain imaging in methamphetamine abusers across the

life-span. Gerontology, 46(3), 122-145.5. Hunt, M.C. & Sher, K.A. (2009). Successful intervention models for older drug-abusers: Research across

the life-span. American Psychologist, in press. NIHMSID: NIHMS99135

Additional recent publications of importance to the field (in chronological order) 1. Gryczynski, J., Shaft, B.M., Merryle, R., & Hunt, M.C. (2002). Community based participatory research with

late-life addicts. American Journal of Alcohol and Drug Abuse, 15(3), 222-238.2. Shaft, B.M., Hunt, M.C., Merryle, R., & Venturi, R. (2003). Policy implications of genetic transmission of

alcohol and drug abuse in female nonusers. International Journal of Drug Policy, 30(5), 46-58.3. Hunt, M.C., Marks, A.E., Shaft, B.M., Merryle, R., & Jensen, J.L. (2004). Early-life family and community

characteristics and late-life substance abuse. Journal of Applied Gerontology, 28(2),26-37.4. Hunt, M.C., Merryle, R. & Jensen, J.L. (2005). The effect of social support networks on morbidity among

elderly substance abusers. Journal of the American Geriatrics Society, 57(4), 15-23.5. Hunt, M.C., Pour, B., Marks, A.E., Merryle, R. & Jensen, J.L. (2005). Aging out of methadone treatment.

American Journal of Alcohol and Drug Abuse, 15(6), 134-149.6. Hunt, M.C., Marks, A.E., Venturi, R., Crenshaw, W. & Ratonian, A. (2007). Community-based intervention

strategies for reducing alcohol and drug abuse in the elderly. Addiction, 104(9), 1436-1606. PMCID: PMC9000292

7. Merryle, R. & Hunt, M.C. (2007). Randomized clinical trial of cotinine in older nicotine addicts. Age andAgeing, 38(2), 9-23. PMCID: PMC9002364

8. Hunt, M.C., Jensen, J.L. & Merryle, R. (2008). The aging addict: ethnographic profiles of the elderly drug user. NY, NY: W. W. Norton & Company.

9. Hunt, M.C. (2009). Contrasting ethnicity with race in the older alcoholic. The Journals of GerontologySeries B: Psychological Sciences and Social Sciences, in press. PMCID: PMC Journal – In Process.

10. Hunt, M.C. (2009). Intervening successfully with the older methadone patient. Journal of AppliedGerontology, 13(4), 67-79.

Program Director/Principal Investigator (Last, First, Middle): Hunt, Morgan C.

OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) Page Biographical Sketch Format Page

D. Research Support

Ongoing Research Support

R01 DA942367-03 Hunt (PI) 09/01/08-08/31/13Health trajectories and behavioral interventions among older substance abusersThe goal of this study is to compare the effects of two substance abuse interventions on health outcomes in an urban population of older opiate addicts.Role: PI

R01 MH922731-05 Merryle (PI) 12/15/07-11/30/12Physical disability, depression and substance abuse in the elderlyThe goal of this study is to identify disability and depression trajectories and demographic factors associated with substance abuse in an independently-living elderly population.Role: Co-Investigator

Faculty Resources Grant, Washington University 08/15/09-08/14/11Opiate Addiction DatabaseThe goal of this project is to create an integrated database of demographic, social and biomedical information for homeless opiate abusers in two urban Missouri locations, using a number of state and local data sources.

Completed Research Support

K02 AG442898 Hunt (PI) 02/01/02-01/31/05Drug Abuse in the ElderlyIndependent Scientist Award: to develop a drug addiction research program with a focus on substance abuse among the elderly.Role: PI

R21 AA998075 Hunt (PI) 01/01/02-12/31/04Community-based intervention for alcohol abuseThe goal of this project was to assess a community-based strategy for reducing alcohol abuse among older individuals.Role: PI

Program Director/Principal Investigator: (Last, first, middle)

OMB No. 0925-0001 (Rev. 08/12 Approved Through 8/31/2015) Page Other Support Format Page

For New and Renewal Applications (PHS 398) – DO NOT SUBMIT UNLESS REQUESTED PHS 398 OTHER SUPPORT

Provide active and pending support for all senior/key personnel. Other Support includes all financial resources, whether Federal, non-Federal, commercial or institutional, available in direct support of an individual’s research endeavors, including but not limited to research grants, cooperative agreements, contracts, and/or institutional awards. Training awards, prizes, or gifts do not need to be included.

There is no “form page” for other support. Information on other support should be provided in the format shown below, using continuation pages as necessary. Include the principal investigator’s name at the top and number consecutively with the rest of the application. The sample below is intended to provide guidance regarding the type and extent of information requested.For instructions and information pertaining to the use of and policy for other support, see Other Support in the Supplemental Instructions, Part III,Policies, Assurances, Definitions, and Other Information.Effort devoted to projects must be measured using person months. Indicate calendar, academic, and/or summer months associated with each project.

NAME OF INDIVIDUALACT I VE/P EN D I NG Project Number (Principal Investigator) SourceTitle of Project (or Subproject)

The major goals of this project are… OVERLAP (summarized for each individual)

Format

Dates of Approved/Proposed ProjectAnnual Direct Costs

Samples

Person Months (Cal/Academic/ Summer)

ANDERSON, R.R.ACTIVE

2 R01 HL 00000-13 (Anderson) 3/1/1997 – 2/28/2002 3.60 calendarNIH/NHLBI $186,529Chloride and Sodium Transport in Airway Epithelial Cells

The major goals of this project are to define the biochemistry of chloride and sodium transport in airway epithelial cells and clone the gene(s) involved in transport.

5 R01 HL 00000-07 (Baker) 4/1/1994 – 3/31/2002 1.20 calendarNIH/NHLBI $122,717Ion Transport in Lungs

The major goal of this project is to study chloride and sodium transport in normal and diseased lungs.

R000 (Anderson) 9/1/1996 – 8/31/2002 1.20 calendarCystic Fibrosis Foundation $43,123Gene Transfer of CFTR to the Airway Epithelium

The major goals of this project are to identify and isolate airway epithelium progenitor cells and express human CFTR in airway epithelial cells.

PENDI NGDCB 950000 (Anderson) 12/01/2002 – 11/30/2004 2.40 calendarNational Science Foundation $82,163Liposome Membrane Composition and Function

The major goals of this project are to define biochemical properties of liposome membrane components and maximize liposome uptake into cells.

Program Director/Principal Investigator: (Last, first, middle)

OMB No. 0925-0001 (Rev. 08/12 Approved Through 8/31/2015) Page Other Support Format Page

OV E R L AP There is scientific overlap between aim 2 of NSF DCB 950000 and aim 4 of the application under consideration. If both are funded, the budgets will be adjusted appropriately in conjunction with agency staff.

RICHARDS, L.NON E

HERNANDEZ, M.ACTIVE

5 R01 CA 00000-07 (Hernandez) 4/1/1995 – 3/31/2002 3.60 academicNIH/NCI $110,532Gene Therapy for Small Cell Lung Carcinoma

The major goals of this project are to use viral strategies to express the normal p53 gene in human SCLCcell lines and to study the effect on growth and invasiveness of the lines.

5 P01 CA 00000-03 (Chen) 7/1/2000 – 6/30/2002 1.80 academicNIH/NCI $104,428 (sub only) 3.00 summerMutations in p53 in Progression of Small Cell Lung Carcinoma

The major goals of this subproject are to define the p53 mutations in SCLC and their contribution to tumor progression and metastasis.

BE 00000 (Hernandez) 9/1/1996 – 8/31/2002 1.80 academicAmerican Cancer Society $86,732p53 Mutations in Breast Cancer

The major goals of this project are to define the spectrum of p53 mutations in human breast cancer samples and correlate the results with clinical outcome.

OV E R L AP Potential commitment overlap for Dr. Hernandez between 5 R01 CA 00000-07 and the application under consideration. If the application under consideration is funded with Dr. Hernandez committed at 3.60 person months, Dr. Hernandez will request approval to reduce her months on the NCI grant.

BENNETT, P.ACTIVE

Investigator Award (Bennett) 9/1/1999 – 8/31/2002 9.00 calendarHoward Hughes Medical Institute $581,317Gene Cloning and Targeting for Neurological Disease GenesThis award supports the PI’s program to map and clone the gene(s) implicated in the development ofAlzheimer’s disease and to target expression of the cloned gene(s) to relevant cells.

OVERLAP: None

Program Director/Principal Investigator (Last, First, Middle):

CHECKLISTTYPE OF APPLICATION (Check all that apply.)

X NEW application. (This application is being submitted to the PHS for the first time.)

RESUBMISSION of application number:(This application replaces a prior unfunded version of a new, renewal, or revision application.)

RENEWAL of grant number: (This application is to extend a funded grant beyond its current project period.)

REVISION to grant number:

(This application is for additional funds to supplement a currently funded grant.)

CHANGE of program director/principal investigator. Name of

former program director/principal investigator: CHANGE of

Grantee Institution. Name of former institution:

FOREIGN application Domestic Grant with foreign involvement List Country(ies) Involved:

INVENTIONS AND PATENTS (Renewal appl. only) No Yes

If “Yes,” Previously reported Not previously reported

1. PROGRAM INCOME (See instructions.)All applications must indicate whether program income is anticipated during the period(s) for which grant support is request. If program income is anticipated, use the format below to reflect the amount and source(s).

Budget Period Anticipated Amount Source(s)

2. ASSURANCES/CERTIFICATIONS (See instructions.)In signing the application Face Page, the authorized organizational representative agrees to comply with the policies, assurances and/or certifications listed in the application instructions when applicable. Descriptions of individual assurances/certifications are provided in Part III and listed in Part I, 4.1 under Item 14. If unable to certify compliance, where applicable, provide an explanation and place it after this page.

3. FACILITIES AND ADMINSTRATIVE COSTS (F&A)/ INDIRECT COSTS. See specific instructions.

DHHS Agreement dated: MM/DD/YYYY No Facilities And Administrative Costs Requested.

DHHS Agreement being negotiated with Regional Office.

No DHHS Agreement, but rate established with Date

CALCULATION* (The entire grant application, including the Checklist, will be reproduced and provided to peer reviewers as confidential information.)

a. Initial budget period: Amount of base $ 29,630 x Rate applied 30.00 % = F&A costs $ 8,889

b. 02 year Amount of base $ 41,487 x Rate applied 30.00 % = F&A costs $ 12,446

c. 03 year Amount of base $ x Rate applied % = F&A costs $

d. 04 year Amount of base $ x Rate applied % = F&A costs $

e. 05 year Amount of base $ x Rate applied % = F&A costs $

*Check appropriate box(es):TOTAL F&A Costs $ 21,335

Salary and wages base Modified total direct cost base Other base (Explain)

Off-site, other special rate, or more than one rate involved (Explain)Explanation (Attach separate sheet, if necessary.):

4. DISCLOSURE PERMISSION STATEMENT: If this application does not result in an award, is the Government permitted to disclose the title of your proposed project, and the name, address, telephone number and e-mail address of the official signing for the applicant organization, to

organizations that may be interested in contacting you for further information (e.g., possible collaborations, investment)? Yes No

PHS 398 (Rev. 08/12 Approved Through 8/31/2015) OMB No. 0925-0001Page Checklist Form Page

Attachment 1: Detailed Budget Assumptions for Illustrative Purposes for New Scholars01 April– 30 01 Dec 2017 – 30 Total

November 2017 Sept 2017 (10 April 2017-NovSalary (8 months) months) 2018Name TBD

RoleScholar intraining

Inst. Base Salary $100,000Salary Request 30% x 18 mos $15,000 $30,000 $45,000Fringe 25% $3,750 $7,500 $11,250Total $18,750 $37,500 $56,250

Travel

HPTN Meetings (2) at start and at 12 months (approximately 4 days)Airfare: New York--DC $500 / RT $500 $5

00$1000Per Diem:DC $295 / Day $1180 $11

80$2360Incidental travel costs

(communications, etc) $50 / trip $5

$5

$100Airport Transfers $100 / trip $100 $1

00$200

HIV/AIDS National Meeting (N=1; 3 days)Airfare: New York--Atlanta $700 / RT $7

00$700Per Diem: Atlanta

Incidental travel costs (communications,

$189 / day

$50 / trip

$567

$

$567

$Airport Transfers $100 / trip $100

$100

HPTN Scholar Mid-Year Meeting (N=1; 3 days)Airfare: New York-- Seattle $500 / RT $5

00$500Per Diem: Seattle

Incidental travel costs (communications,

$280 / day

$50 / trip

$840

$

$840

$Airport Transfers $100 / trip $100

$100

Meetings with out of town mentor (4 trips of 5 days each) – if applicableAirfare: New York--DC $500 / RT $1000 $10

00$200

0Per Diem:DC $295 / day $2950 $2950

$5900Incidental travel costs

(communications, etc) $50 / trip $100 $100

$200Airport Transfers $100 / trip $200 $2

00$400

Other Direct Costs – if applicableTelecommunication costs for monthly calls $1

25$125Photocopying of key prevention articles, manuals,

etc $1

25$125General office supplies: books; software

Laptop $1

25 $15

$125

Total Direct Costs $26,705 $46,487 $73192

Indirect Costs (max. 30%) $7,562 $13,946 $21,508

TOTAL COSTS $34,267 $60,433 $94,700

Notes: The mid-year meeting takes place in Seattle and the Annual Meeting in DC each year.