Microwave Synthesis Solutions

7/28/2019 Microwave Synthesis Solutions

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::: Excellence in Microwave Synthesis

Microwave Synthesis Solutions


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The Complete Family:

Microwave Synthesis

Since its beginning in 1986, microwave synthesis has successfully matured, particularly within the

last decade. All the while, Anton Paar has continuously designed and introduced reliable and versatile

microwave instrumentation that fulfils the requirements of modern academic and industrial research.

The new generation of Anton Paar microwave synthesis solutions is developed in response to the

increasing demand , particularly in the pharmaceutical industry, for straight-foward solutions that

cover the entire range of microwave synthesis applications: from initial R&D to kilolab processing.

The key: Direct scalability

Method transfer from the development stage to larger quantities is a major concern in microwave

synthesis. As no microwave effects are involved, the reliability of a method solely depends on the

temperature measurement. Accurate internal temperature measurement and the resulting knowledge

about the real reaction temperature is the key issue for successful scale-up.

Once the reaction temperature is known, an optimized protocol can be applied in any suitable scalewithout losing efficiency.

Serving your needs in drug discovery

From smallest quantities to gram-scale library generation and multigram batch processing -

the initial steps of the drug development process are completely covered by the members of the

Anton Paar microwave synthesis product family. You can be sure to find the right solution for your

specific application.

Any chemistry, any scale, anyone, anywhere!


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Getting started

Method development with Monowave 300 opens up

pathways to new reaction routes for a broad variety of

applications.

Sequential method optimization employing MAS 24 with

Monowave 300 or parallel optimization with the silicon

carbide rotors ofSynthos 3000 considerably facilitates

chemists everyday work.

Want more?

For parallel scale-up to the multigram range, use Rotor 16.

Direct scalability of your optimized methods allows for library

generation in significant gram amounts.

Looking for extremes? The combination ofSynthos 3000 and

its Rotor 8S is the proper choice.

The big deal!

Batch-type processing in the liter scale with Masterwave BTR

leads to as much as 250 g product in a single run.

The identical software user interface allows direct method transfer

from Monowave 300. Simply multiply the amounts of your mixture

and follow your optimized protocols.


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The Monowave 300 monomode microwave

reactor provides a completely new andsophisticated approach towards microwave

synthesis, turning previously unachievable

reliability and performance into three-

dimensional fact.

Extended operation limits up to 300 C and

30 bar (435 psi) provided by a single 850 W

magnetron open up unforeseen opportunities

for method development and optimization.

Reliable mate

Monowave 300 your trustworthy workhorse in student

education, pharmaceutical research, material science, polymer

chemistry and much more opens up pathways to new

reaction routes for a broad variety of applications. Reliability,

scalability and reproducibility are proven in great detail.

Serving individual needs

Different reaction vials provide access to various scales from

0.5 mL to 20 mL reaction volume. There is no hassle with

varying caps one size fits all vials. In addition, the extended

reusability of all items keeps running costs low.

Even harsh and tricky chemistry involving corrosive reagents

or low absorbing solvents is easily performed. A special 10 mL

reaction vessel made of silicon carbide allows for trouble-free

processing and even supports investigations into microwave

effects.

Accurate process control

Monowave 300s immersing ruby-based fiber optic sensor

ensures immediate feedback, approaching the peak of

precision in temperature measurement. Accurate knowledge of

reaction temperature is the key factor for efficient, successful

scale-up.

New Dimensions for R&D

Monowave 300


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The MAS 24 autosampler unit for Monowave 300 provides

reliable unattended sequential operation.

Up to 24 vials of different size are easily queued and

processed automatically. The smart software-guided loading

strategy in combination with a separate vial insert and

handling position prevents sample mix-ups.

Any basic Monowave 300 reactor is easily upgraded to an

automated version.

Take home your advantage

4 Rapid and uniform heating4 Utmost accuracy and reproducibility

4 New dimensions of method development & optimization

4 Simultaneous internal & IR temperature measurement

4 Powerful stirring for optimized agitation

4 Built-in touchscreen controller

4 User-friendly intuitive software

4 Durable & reusable vials, caps and septa

4 Minimum lab space required

4 Dependable gripper driven by compressed air

4 Different carousels with maximum capacity

4 Comprehensive data management

MAS 24

Seamless Automation

Applicable vial types

Carousel types for MAS 24


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Scale Out and Prosper

Synthos 3000

The Synthos 3000 multimode microwave reaction

system has been developed to enhance theperformance of microwave-assisted synthesis.

Two magnetrons provide 1400 W unpulsed

microwave output power for uniform heating.

The systems installation-free wireless sensor

technology facilitates handling and optimizes

reaction control, leading to highly reproducible

results.

Valued versatility

The versatile Synthos 3000 platform provides small-scale high-

throughput rotors for parallel optimizations and library generation

as well as large-scale rotors for multigram parallel synthesis.

The systems proven scalability ensures seamless scale-up

from the milligram to the multigram range without changing

instruments.

Exceptional reaction conditions allow users to establish

completely new reaction pathways, including near-critical waterconditions.

With a simple rotor switch, the scope of your microwave

synthesis is easily extended.

Rotor type 4x48MC Well Plate 4x20MGC 4x24MG5 64MG5

Reaction container6x8 SiC

microtiter plate

HPLC/GC vial in

5x4 SiC plate

Glass vial in

6x4 SiC plateGlass vial

Reaction volume 0.1 0.3 mL 0.1 1.5 mL 0.3 - 3.0 mL 0.3 - 3.0 mL

Max. temperature 200 C 200 C 200 C 200 C

Max. pressure 20 bar 20 bar 20 bar 20 bar


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The perfect match

Thorough investigations and exceptional design lead to a

family of small-scale rotors for Synthos 3000 that perfectly

match the requirements for microwave-assisted parallel

synthesis in a combinatorial manner.

The silicon carbide employed in Rotor 4x48MC Well Plate,

Rotor 4x20MGC and Rotor 4x24MG5 opens extraordinary

avenues for method development. Being an excellent

microwave absorber, SiC allows the use of any kind of

solvent for microwave synthesis. In fact, virtually microwave-

transparent compounds such as toluene or dioxane can be

heated rapidly in SiC plates.

This small-scale high-throughput equipment is especially

useful for applications related to the drug development

process, forensics, proteomics and other research areas

which predominantly deal with small sample quantities.

Parallel Synthesis

Rotor types for reaction screening and parallel

optimization

Various types of available SiC plates


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Scale Up and Explore

Synthos 3000

Synthos 3000 already provides certain

scalability within its various rotor types. All

methods developed in the small-scale rotors

can be applied in the high-performance rotors

with their 100 mL reaction vessels.

The different rotor and vessel types provide the

best solutions for your individual experimental

tasks. Multigram parallel synthesis as well

as parallel batch processing are served in all

high-performance rotors. The vessels andpressure jackets are easily Interchangeable,

allowing for simple upgrade to a high-pressure

configuration at any time.

Anything special?

Benefit from a variety of Synthos 3000 accessories:

With the sophisticated gas loading system, a reactive or

inert gas atmosphere is individually created in each vessel.Pressures up to 20 bar can be applied prior to reactions for

safe and effective syntheses employing sensitive substrates.

Utilizing standard HPLC/GC vials as proper inserts for the

100 mL vessels enables protein hydrolysis in mg quantities

in a high-throughput manner.

Thick-walled quartz vessels enable conditions up to 300 C and

80 bar and are even suitable for hydrothermal nanomaterial

synthesis and near-critical water chemistry.

Even photochemistry applications can be served with

microwave-induced UV lamps.

Rotor type 48MF50 16MF100 16HF100 8SXF100 8SXQ80

Reaction vessel 50 mL PFA 100 mL PTFE-TFM 100 mL PTFE-TFM 100 mL PTFE-TFM 80 mL Quartz

Reaction volume 6 - 25 mL 6 - 60 mL 6 - 60 mL 6 - 60 mL 6 - 60 mL

Pressure jacket PEEK PEEK Ceramic Ceramic n/a

Max. temperature 200 C 200 C 240 C 260 C 300 C

Max. pressure 20 bar 20 bar 40 bar 60 bar 80 bar


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Features & benefits

4 Reliable temperature and pressure sensors

optimized reaction control

4 Installation-free remote sensor technology easy

handling, wireless data transmission

4 Applied silicon carbide technology efficient,

homogeneous heating of small quantities

4 Sophisticated accessory simplified advanced processing

4 Highest accessible reaction conditions extending the

scope of microwave synthesis

4 Multiple safety system safe, trouble-free processing at

extreme conditions

All-purpose setup

The individual parallel synthesis rotors for Synthos 3000 are

your reliable partners in drug discovery, biomedical sciences,

nanomaterial research, forensic medicine and much more.

The basic Synthos 3000 instrument hosts all rotor types.

Once the system is installed in your lab, future upgrades are

possible at any time.

High-performance Synthesis

Easy-handling gas loading system

Microwave-induced UV lamps


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Microwave Goes Kilolab

Masterwave BTR

Based on a revolutionary new technique

(patent pending, US 2009/0194528), theMasterwave benchtop reactor closes the gap

between research and kilolab processing in

microwave synthesis.

The powerful instrument overcomes heating

difficulties in scale-up and provides efficient

heating and utmost productivity for a

1L reactor. Its rising-sensor temperature

measurement technique provides the

temperature accuracy required for direct

method transfer from any smaller microwave

device to the liter scale.

A kilo a day

Total reaction volumes of up to 750 mL and the powerful

stirrers capacity for agitating up to 200 g solid material

ensures unrivaled productivity in a single run. Additionally,

the instruments integrated cooling system shortens overallprocess times.

Each reaction vessel comprises its own paddle stirrer and cap

with lip-type seal. This enables you to optimize your workflow,

since you can prepare the next batch while processing the

batch at hand.

As a result, with up to 12 subsequent cycles in a standard 8h

shift, the daily production of kilogram amounts by microwave

synthesis becomes a reality.

Pioneering walk on, walk off solution

Despite its enhanced productivity, Masterwave BTR is still

standard laboratory equipment.

Placed in a regular fume hood and connected to the

corresponding interfaces, any chemistry can be started right

away.

No specific safety measures have to be observed, no

extraordinary pre-installation measures are required simply

use the available lab space in the most efficient way.

For your convenience, processing can also be controlled via

an optional remote control from any desktop PC.


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A New Dimension in

Microwave Synthesis

1 L PTFE reaction vessel with integrated

paddle stirrer

Inserting the vessel

Pushing technical frontiers

4 1700 W applicable microwave power

4 Reaction conditions up to 250 C and 30 bar

4 Rising Pt100 sensor for internal temperature measurement

4 Sliding cover with embedded hydraulic pressure sensor

4 Bayonet-locked 1 L PTFE reaction vessel

4 Vessel-integrated magnetically driven paddle stirrer

4 Internal closed-cycle cooling system

4 Compressed-air-driven vessel ejector

Microwave synthesis excels in:

4 Method development, optimization, and scale-up4 Building block synthesis

4 Scaffold decoration

4 Metal-catalyzed reactions

4 Preparation of nanoparticles

4 Hydrothermal zeolite synthesis

4 Solid-phase reactions

4 Polymer synthesis

4 Ionic liquid chemistry


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Fotos: Croce & Wir

Specifications

subject to change

without notice.

Instruments for:

Density & concentration

measurement

Rheometry & viscometry

Sample preparation

Microwave synthesis

Colloid science

X-ray structure analysis

Refractometry

Polarimetry

High-precision temperature

measurement

Anton Paar GmbH

Anton-Paar-Str. 20

A-8054 Graz

Austria - Europe

Tel: +43 (0)316 257-0

Fax: +43 (0)316 257-257E-mail: [email protected]

Web: www.anton-paar.com

Documents

Microwave Synthesis Solutions