Misused Drug 23.4.52lecture set

8/8/2019 Misused Drug 23.4.52lecture set

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1. 2.

1.

2.


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:

1

12-65

1.6 % (

45 % )11.9 %

( 20 )

:


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(Drug Abuse)


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(WHO)

: Bio-psycho-socialfactors


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General care &

treatment (Drug

treatment)Antidote -VS-agonist Symptomatictreatment Supportive

treatment Psychologicaltreatment Sociological

support


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Classification 1.

(Psychotomimetics ,hallucinogens:LSD,

psilocybin, mescaline)

2. (Psychomotor stimulants ,CNS stimulants

:amphetamine,,, cocaine)3. (CNS

depressants: opioid, sedative/hypnotic,

alcohol)

4. : Mixed action substances (THC,


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1. conscious experi

environmentaGood trip Bad trip

serotonin


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Lucy In The SkyWith Diamondsby The Beatles

1.Lysergic acid diethylamide

(LSD,)

N

NH2

CH3

C

O

N

CH2CH

3

CH2CH3

LSD

..

psychotomimetics


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ergot alkaloid (Clavicep

purpurea) : 5-HT2 receptor(hallucination - bad trip)

:

:

LSD


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serotonin

(Hallucination)

LSD


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2.Magic mushroom:

Psilocybin


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3. Mescaline: CH2CH2NH2H3CO

H3CO

OCH3

Mescaline


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2. (psycho

Amphetamine, Methamphetamine MethylenedioxymethamphetamineMDME

Cocaine Coke

Ephredrine


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Amphetamine (,)Dex-Amphetamine()Meth- Amphetamine(Ice)

MDMA (Ecstasy, )codeine

Amphetamine

derivatives


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21-26 Ecstasy

(ketamine) (Cocaine)


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Noradrenaline Dopamine

Serotonin


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- (euphoria)- (talkative)- -

- - -

- - (aggression)- (stereotyped)- Dementia- Depression

,


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Erythroxylon coca


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Crack addicted woman


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cocaine


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3. 1.

(Disinhibition)

(ataxia)

amphetamin

Ethanol Acetaldehyde A - Disulfiram


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>

20 / 46 = 11.9%, 11 % 8%

:

: - DeliriumTremens (, , , ), Wernickes encephalopathy &Korsakoffs psychosis, etc

(Withdrawal symptom):

, , ,

Alcohol


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2. (Marijuana)Cannabis sativa

tetrahydrocannabin

- ()-

sex hormones- (- :, ,,

2:

&


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(neuroad


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3. : = 3:1- Ketamine - benzodiazepines di

(VALIUM), flunitrazepam (

,

- Barbiturates also called seconal, etc


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BRB BDZ


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4.Heroin Morphine

(


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Heroin drug addict :needle inject l


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4.

1. ,,marker pen,

hydrocarbon(toluene, benzene, ethyl a ethanol

(mood)

,,


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: , &

: : , :(life supportfor overdose)

Volatile substances

(

)


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Cannabissativa (, hemp,grass, marijuana, pot,etc)

530 30-60 2-3.

44 3 10,000

THC (Tetrahydro cannabinol )

THC(


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:

(

dopamine

),( )

:

,

&

:,

,,

THC(

)


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(Mitragynine alkaloid) : &

( )

Skinsensitive to rain :,,

Mitragynine


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2. (steroids)

- muscle mass--

---

5-12%

male1% femalehigh school st


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-- cholesterol--

- sexual functions- abnormal breast development- shrinking of the testicles-

-

---


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2 1. 2.


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--,-,

-- -


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1.

80.43% : 56.52%, 1

: (prednisolone (dexameth


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:--

--obese trunk

-moon face & buffalo hump

-,


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2.,

:--:

Diclofenac (VOLTAREN)

Piroxicam (FELDENE)Ibuprofen (BRUFEN, NUROFEN)


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3.

:NORGESIC, MUSCOL= +MYDOCALM = ALAXAN = +


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4. - amoxicillin, ampicilli

erythromycin, roxith

BACTRIM, CO-TRI

norfloxacin, ciprofloxa

,

,,


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5.

, 77,Cimetidi-

6.

LOMOTIL, IMMODIUM,,


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7. , (D,


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NSAIDs NSAIDs >1

>1

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Misused Drug 23.4.52lecture set