Mitochondria – ER rewiring as instigator or backer of aging & cancer › fileadmin › institute-oes › ... · 2016-07-05 · LIST of APPENDICES: Mitochondria – ER rewiring as

LISTofAPPENDICES:

Mitochondria–ER rewiringas instigatoror

backerofaging&cancer

APENDIX1:Curriculumvitaeoftheconsortiummembers(limitedto1pageeach)

APENDIX2:10mostrelevantpublicationswithauthorleadofeachmember

APPENDIX3:Thecompletelistofgrantedprojectsforeachmember

EvaMariaBERNHART,InstituteofMolecularBiologyandBiochemistry,MedicalUniversityRuthBIRNER-GRÜNBERGER,InstituteofPathology,MedicalUniversityofGraz,8010Graz,AustriaJulianeG.BOGNER-STRAUSS,InstituteofBiochemistry,GrazUniversityofTechnologyTobiasEISENBERG,InstituteofMolecularBiosciences,UniversityofGrazWolfgangF.GRAIER,InstituteofMolecularBiologyandBiochemistry,MedicalUniversityofGrazGünterHÄMMERLE,InstituteofMolecularBiosciences,UniversityofGrazTobiasMADL,InstituteofMolecularBiologyandBiochemistry,MedicalUniversityofGrazRolandMALLI,InstituteofMolecularBiologyandBiochemistry,MedicalUniversityofGrazMartinPICHLER,DepartmentofOncology,MedicalUniversityofGrazWolfgangSATTLER,InstituteofMolecularBiologyandBiochemistry,MedicalUniversityofGrazMichaelR.SPEICHER,InstituteofHumanGenetics,MedicalUniversityofGraz

APENDIX1:Curriculumvitaeoftheconsortiummembers(limitedto1pageeach)

MitACan:Mito-ERcrosstalkinAging&Cancer

APPENDIX1

Curriculumvitae Name

EvaBernhart,SeniorLecturer,Mag.Dr.rer.nat.

Affiliation:Seniorlecturer,InstituteofMolecularBiologyandBiochemistry,MedicalUniversityofGraz

Personaldata:DateofBirth:March24,1968/PlaceofBirth:Wagna,Austria/Nationality:Austrian

Education:1986-1996 StudyofZoology,UniversityofGraz,Austria1996-2000 PhDinBiology,UniversityofGraz,Austria

CareerHistory:1996 Masterdegree(Mag.rer.nat.)inBiology,UniversityofGraz1996-2000 ResearchAssistant&PhD(supportedbyFWF),InstituteofMedicalPhysicsandBiophysics,

UniversityofGraz1999-2001 CoordinatorofClinicalStudies,DepartmentofAnesthesiologyandIntensiveCareMedicine,

UniversityofGraz2000-2003 PostDoc(supportedbytheFWF),InstituteofMedicalPhysicsandBiophysics,Universityof

Graz2003-2013 PostDoc(supportedbytheÖNBandFFG),InstituteofMolecularBiologyandBiochemistry,

MedicalUniversityofGrazSince2014 SeniorLecturer,InstituteofMolecularBiologyandBiochemistry,MedicalUniversityofGrazAwardsandDistinctions:20052008

Sanofi-AventisAward,Co-authorPhoenixPharmacyAward,Co-author

H-Index(Scopus):12(June2016)

CumulativeImpactpoints:122(June2016)


APPENDIX1

CurriculumvitaeName

RuthBirner-Grünberger,Assoz.-Prof.,Dipl.-Ing.,Dr.techn.

Affiliation:Assoc.Prof.,InstituteofPathologyHead,OmicsCenterGrazMedicalUniversityofGraz

Personaldata:DateofBirth:March24,1973/PlaceofBirth:Graz,Austria/Nationality:Austrian

Education:1991-1998 StudyofTechnicalChemistry,UniversityofTechnologyGraz,Austria1996-1997 BachelorHonorsdegreeequivalentinAppliedBiology(highdistinction),RMIT,Melbourne,

Australia1998 Masterdegree(Dipl.-Ing.)inTechnicalChemistry(summacumlaude)1998-2002 PhD(Dr.techn.)inTechnicalChemistry(summacumlaude),DepartmentofBiochemistry,

UniversityofTechnologyGraz,Austria

CareerHistory:2001-2003 UniversityAssistant,DepartmentofBiochemistry,UniversityofTechnologyGraz,Austria2002-2007 PostDoc,DepartmentofBiochemistry,UniversityofTechnologyGraz,Austria2007 HabilitationinBiochemistry2007-2011 Director,CoreFacilityMassSpectrometry,MedicalUniv.Graz,Austria2011-2014 ScientificDirector,CoreFacilityMassSpectrometry,MedicalUniv.Graz,Austriasince2011 AssociateProfessor,InstituteofPathology,MedicalUniv.Graz,Austriasince11/2013 Head,OmicsCenterGraz,Graz,Austriasince2015 President,AustrianProteomicsAssociation06-08/2016 VisitingProfessor,ETHZürich,Switzerland

AwardsandDistinctions:2009,2006 Excellentpaperaward(AESCA/MSDPreis),AustrianAtherosclerosisSociety(AAS),St.

Gilgen,Austria2008 KardinalInnitzerFörderungspreis(ResearchawardforexcellentHabilitation)2001-2006 Numerouspresentationawardsandtravelscholarshipsatinternationalconferences1996-1997 (Travel)ScholarshipsofUniv.ofTechnol.GrazandStyriangovernment

Editorialresponsibilities:Since2008 EditorialBoardTheOpenProteomicsJournalSince2010 EditorialBoardTheIntegrated-OmicsJournalSince2012 EditorialBoardJournalofProteomicsInvitedreviewerfor:Journals:Nat.Chem.Biol.,Hepatol.,Bioconjug.Chem.,ChemBioChem,PLOSone,Proteomics,J.ofProteomics,TheIntegrated-OmicsJournal,TheOpenProteomicsJournal,BBA,JournalofProteomeResearch&othersGrantoffices:Austria,EC,Germany,Denmark,UK

Funding: overall€4.663Mio(since2006)

Patents: 2patents(WO2013024100,WO2006010403)




APPENDIX1

CurriculumVitaeName

JulianeBogner-Strauss(neeStrauss),Assoc.Prof.MSc,PhD

Affiliation:

Assoc. Prof., Institute of Biochemistry, Graz University of Technology,Humboldtstrasse46/3,8010Graz,Austria

Personaldata:PlaceofBirth Wagna,Austria/Nationality:AustriaChildren 3children(born2011,2008,1999)

ResearchInterests Adipogenesis, (energy) metabolism and lipid signaling in obesity & associateddisorders; N-acetylaspartate and acetyl-CoA homeostasis & protein acetylation,autophagyandrelateddisorders

CareerHistory:Since2014 AssociateProfessorattheInstituteofBiochemistry,GrazUniversityofTechnology,

Austria(since2016DebutyHead)2010-2013 Associate Professor & Deputy Head at the Institute for Genomics and

Bioinformatics,GrazUniversityofTechnology,Austria2008 Habilitation(VeniadocendiforMolecularBiologyandGenomics)2005-2009 Assistant Professor & Deputy Head at the Institute for Genomics and

Bioinformatics,GrazUniversityofTechnology,Austria2003-2004Post-DoctoralFellowandUniversityAssistantattheInstituteofMolecularBiosciences,

UniversityofGraz,Austria(Prof.RZechner)1999-2002 PhD passed with distinction at the Institute of Molecular Biosciences (Prof. R.

Zechner),UniversityofGraz,Austria

AwardsandDistinctions:Since2016 ApprovedMemberofBioTechMedGrazStartingOct2016 HeadoftheDoctoralSchoolofMolecularBiomedSciences&Biotechnology2015-2016 Selectedforthe“LeadingWomen”leadershipprogram,GrazUniversityof

Technology2014 YoungInvestigatorsinLipidScience,Düsseldorf,Germany(invitedtalk)Since2013 MemberAmericanSocietyforBiochemistryandMolecularBiology(ASBMB)2013 AnnualmeetingoftheAustrianSocietyforobesity,Austria.“BrownAdiposeTissue

Physiology”(invitedtalk)2013 N-acetyltransferase 8-like: implications in brown adipocyte metabolism through

PPARasignaling.KeystoneSymposium,Austria(selectedtalk)2011 APMAP: a transmembrane protein required for adipogenesis and targeted by

PPARg.KeystoneSymposium,Colorado,USA(selectedtalk)Since2008 Reviewer for peer-reviewed Journals (Journal of Biochemistry, Scientific Reports,

JournalofLipidResearch,PlosOne,etc)March-April2003 UniversityofDenver,CO,USA,CollaborationwithProf.RobertH.EckelNovember2003 UniversityofLeiden,Netherlands,CollaborationwithProf.MirandavanEck

Funding: overall2.050k€(2006-2016)

Patent:US20120009613A1,12.01.2012




APPENDIX1

CurriculumvitaeName

Eisenberg,Tobias,Dr.,Dipl.-Biochem.

Affiliation:Ass.-Prof.,InstituteofMolecularBiosciencesHead,NAWI-GrazCentralLabGraciaUniversityofGraz

Personaldata:DateofBirth:November28,1977/PlaceofBirth:Münster,Germany/Nationality:GermanChildren:Lieselotte(3),Florentine(1)

Education:1998-2004 StudyofBiochemistry,UniversityofTübingen,Germany2004-2008 PhDinMolecularBiology,InstituteofMolecularBiosciences,Univ.Graz,Austria

CareerHistory:2004 Diplomadegree(Dipl.-Biochem.)inBiochemistry2004-2008 PhD(supportedbyFWFandEU),Aging&CellDeath,Univ.Graz2008-2013 Post-DoctoralFellow(supportedbyEUandFWF),Inst.ofMol.Biosciences,Univ.Graz2013-2016 ProjectleaderatUniv.Graz;Acetyl-CoA,Autophagy&Aging,APARTprogramofthe

AustrianAcademyofSciences(ÖAW)2014 Researchstay(4mth),Prof.StefanSigristlab,FUBerlin,Germany(Drosophilaagingmodels)since11/2014 Head;NAWIGrazCentralLabGracia:Fluorescence-basedcellsorting&analysis–Grazsince03/2016 Ass.-Prof.ofMolecularBiology,InstituteofMolecularBiosciences,Univ.Graz

AwardsandDistinctions:2011 StyriaScienceAwardforYoungScientists(‚FörderungspreisdesLandesSteiermark‘),Austria2013-2016 APARTfellowshipoftheAustrianAcademyofScience(ÖAW),Vienna,Austria

Editorialresponsibilities:Since2015 MemberoftheEditorialBoardat“MicrobialCell”Invitedreviewerfor:Journals:Autophagy,FrontiersinOncology,CellDeathDiff.,Mech.AgeingDev.,PlosOne,YeastGrantoffices:UKParkinsonsdiseaseSociety

Funding: €215,000(since2013)

Patents: 1patent(US13/181,698/EP10703635.2)




APPENDIX1

CurriculumvitaeName

WolfgangGraier,Univ.-Prof.Mpharm,PhD

Affiliation:Univ.-Prof.&Chair,InstituteofMolecularBiologyandBiochemistryHead,NIKON-CenterofExcellenceMedicalUniversityofGraz

Personaldata:DateofBirth:March4,1963/PlaceofBirth:Graz,Austria/Nationality:AustrianChildren:Stefan(23)&Thomas(21)

Education:1981-1988 StudyofPharmacy&PharmaceuticalChemistry,UniversityofGraz,Austria1988-1991 PhDinPharmacology,DepartmentofPharmacologyandToxicology,Univ.Graz,Austria

CareerHistory:1988 Masterdegree(Mag.pharm.)inPharmaceuticalScience(summacumlaude)1989-1991 ResearchAssistant&PhD(supportedbyFWF),Pharmacology&Toxicology,Univ.Graz1991-1992 Militaryservice,St.MichaelandGraz,military-pharmacist1992-1993 ResearchAssistant(supportedbytheFWF),Pharmacology&Toxicology,Univ.Graz,Austria1993-1994 PostDoc,DaltonCardiovascularResearchCenter,Univ.Missouri,Columbia,MO,USA1994-1995 AssistantProfessor,MedicalBiochemistry,Univ.ofGraz,Austria1995 HabilitationinBiochemicalPharmacology1995-2009 AssociateProfessor,MedicalBiochemistry&MedicalMolecularBiology,Univ.Graz,Austria2001 HabilitationinPhysiologysince05/2009 FullProfessorofMolecularBiology,MolecularBiology&Biochemistry,MedicalUniv,Grazsince09/2009 ChairoftheInstituteofMolecularBiology&Biochemistry,MedicalUniv.Graz,Austriasince06/2015 Head;NIKON-CenterofExcellence:Super-resolutionmicroscopy:Cells&Organelles-Graz

AwardsandDistinctions:1991 HerbaAward1991,Vienna,Austria1994 Otto-Loewi-Award,Vienna,Austria1995,1999 ParacelsusAward,AustrianSocietyofInternalMedicine,Austria95,04,06,07 Sanofi/Höchst-Award,Austria(04,06&07asSenior-Author)1996 Bristol-MyersSquibbAward,Austria2002-2006 CouncilMember&VicePresidentoftheEuropeanSocietyofClinicalInvestigationsince2008 memberoftheACADAEMIAEUROPAEA(SectionPhysiology&Medicine)2009/2010 Teachersoftheyear2009/2010,MedicalUniversityofGraz

Editorialresponsibilities:2000-2003 AssociateEditorforDiabetologia&EditorforBritishJournalofPharmacologysince2015 Editor(SectionMolecularandExperimentalMedicine)forOpenMedicinesince01,08,10 EditorialBoard:J.Cardiovasc.Pharmacol.,PflugersArchive,&FrontCardiovPharmacolInvitedreviewerfor:Journals:Science,Nat.CellBiol.,Nat.Commun.,CellReports,EMBOJ.,PNAS,Circ.Research&othersGrantoffices:Austria,CzechRepublic,Germany,HongKong,Israel,Italy,UK,USA

Funding: overall€8.559Mio(since1991)Patents: 3patents(WO2006077241,GB1419073.0,GB1417140.9)

H-Index(Scopus):41(June2016)CumulativeImpactpoints:673(June2016)


APPENDIX1

CurriculumvitaeName

GuenterHaemmerle,Assoc.-Prof.,PhD

Affiliation:Assoc.Univ.-Prof.,InstituteofMolecularBiosciencesUniversityofGraz

Personaldata:DateofBirth:April6,1967/PlaceofBirth:Lustenau,Austria/Nationality:AustrianChildren:LukaSophie(9)&Ella(6)

Education:1990-1997 Master´sstudies(M.Sc.)inBiology,UniversityofGraz,Austria1997-2001 PostgraduateStudyinBiochemistry,UniversityofGraz,Austria

CareerHistory:2001-2004 PostDocattheInst.ofMolecularBiosciences(IMB),UniversityofGraz,Austria2004-2005 SeniorPostDocattheIMB,UniversityofGraz,Austria2005-2010 UniversityAssistantattheIMB,UniversityofGraz,Austria (2008HabilitationinMolecularBiologyandBiochemistry)Since2010 AssociateProfessorattheIMB,UniversityofGraz


Patent:US20120009613A1,12.01.2012




APPENDIX1

CurriculumvitaeName

TobiasMadl,Assoz.Prof.,Dr.

Affiliation:Assoz.Prof.,InstituteofMolecularBiologyandBiochemistryMedicalUniversityofGraz

Personaldata:DateofBirth:July1,1980/PlaceofBirth:Graz,Austria/Nationality:AustrianChildren:NikolausNepomuk(6)

Education:1998-2004 StudyofChemistry,PhysicsandHistory(teachership),UniversityofGraz,Austria(1year

interruptionduetoalternativecivilianservice)2004-2007 PhDinChemistry,DepartmentofChemistry,Univ.Graz,Austria

CareerHistory:1999-2000 AlternativecivilianserviceatthelaboratoryoftheLandeskrankenhausGraz(hospital)2001-2005 Researchassistant,InstituteofChemistry,Univ.Graz2003-2007 (Grantfunded)industrialresearchforBiodieselInternationalLtd.,Graz2004 Masterdegree(Mag.rer.nat.)inChemistryandPhysics2004-2007 ResearchAssistant&PhD(supportedbyÖAW,FWF),InstituteofChemistry,Univ.Graz2006-2007 IndustrialresearchforSanochemiaPharmazeutikaAG,Graz2006- VisitingscientistatBrukerBiospin,Karlsruhe,Germany2007 PostDoc,InstituteofChemistry,Univ.Graz2007-2010 PostDoc,Chemistry/InstituteofStruct.Biol.,TU&HelmholtzCenterMunich,Germany2009- VisitingscientistatthesynchrotronsESRFGrenoble/France&DESYHamburg/Germany2010-2011 PostDoc,BijvoetCenter,UtrechtUniversity,TheNetherlands2012 APARTfellowatUtrechtUniversity,TheNetherlandsandUniv.Graz2012-2016 EmmyNoetherresearchgroupleader,HelmholtzZentrumMunich2012-2016 BioSysNetresearchgroupleader&TUMJuniorFellow,TUMunich2013-2016 MemberoftheJuniorScientistProgram(Tenure-Track),HelmholtzZentrumMunichsince01/2015-AssociateProfessoratMedicalUniversityGrazAwardsandDistinctions(selection):2005 DOCscholarshipoftheAustrianAcademyofSciences(ÖAW)2008 PhDPrizeoftheAustrianChemicalSociety;EMBOLongTermFellowship(LTF); SchrödingerFellowshipoftheAustrianScienceFund(FWF)2012 ScienceAwardoftheAustrianChemicalSociety,APARTfellowshipoftheÖAW2015 President’sInternationalFellowshipoftheChineseAcademyofSciences(CAS);The

ResearchFellowshipforInternationalYoungScientistsoftheNationalNaturalScienceFoundationofChina(NSFC)

2007 PhDfinishedwithhighestdistinction(“MitAuszeichnungbestanden”,averagegrade1.0)Invitedreviewerfor:Journals:Ang.Chemie,J.Am.Chem.Soc.,ChemBioChem,ChemPhysChem,J.Biomol.NMR&othersGrantoffices:Austria,Germany,TheNetherlands,Israel





APPENDIX1

CurriculumvitaeName

RolandMalli,Assoc.-Prof.Mpharm,PhD

Affiliation:Mag.pharm.,Dr.rer.nat.,Priv.-Doz.,Assoc.Prof.InstituteofMolecularBiologyandBiochemistryResearchUnitofMolecularandCellularPhysiologyMedicalUniversityofGrazE-mail:[email protected]

Personaldata:DateofBirth:August15,1971/PlaceofBirth:Wagna,Austria/Nationality:Austrian/MarriedwithMag.apharmSandraMalli/2children:Anna(13)&Leni(10)

Education:1985-1989 Bundesoberstufenrealgymnasium,Deutschlandsberg,Austria1990-1999 StudyofPharmacyattheKarl-FranzensUniversityofGraz1999-2002 PhDinnaturalscienceattheMedicalUniversityofGraz

CareerHistory:1999: MasterinPharmacy,UniversityofGraz1999-2001 ResearchFellowattheInstituteofMolecularBiology&Biochemistry,MedicalFacultyGraz2002: PhDinPharmacology&Biochemistry,MedicalFacultyGraz2002-2004 ResearchAssistantforSERVIERInternational(France)2004-2010 AssistantProfessorattheInstituteofMolecularBiology&Biochemistry2007: Habilitationin(MolecularandCellular)Physiology,MedicalUniversityofGrazSince2010 AssociatedProfessoratInstituteofMolecularBiology&Biochemistry,2015: Headofthesuperresolutionmicroscopy(SIM)laboftheNikoncenterofexcellence2016: ChiefOperatingOfficeroftheNGFIGmbH

AwardsandDistinctions:2003 BestPaperAwardSFBBiomembraneResearchCenterGraz(firstauthor)2004 Sanofi-AventisAward(co-author)2006 Sanofi-AventisAward(firstauthor)2007 Sanofi-AventisAward(co-author)2008 OttoKrauppAward2015 Inventoroftheyear/MedicalUniversityofGraz/BioTechMedGraz

ResearchinterestsMolecularandcellularphysiology,Ca2+ signaling, cell, signaling,geneticallyencoded fluorescenceprobes,fluorescencemicroscopy,mitochondria,cellmetabolism,endoplasmicreticulumfunctions,cancerbiology,degenerativediseases

Currentthird-partyfunding:FWFProjectP28529;2016–2018Title:“TheEnergySupplyoftheEndoplasmicReticulum”336042,00€Funding: overall€1.0557Mio(since2010)

Patents: 3patents(WO2006077241,GB1419073.0,GB1417140.9)




APPENDIX1

CurriculumvitaeName

MartinPichler,Assoc.Prof.PDDr.med.univ.Mag.rer.nat

Affiliation:AssociateProfessorandResearchManagingDirector,DivisionofOncologyHead,ResearchUnitofNon-codingRNAandGenomeeditinginCancerMedicalUniversityofGraz,AustriaAdjunctAss.ProfessorDivisionofMedicine,DepartmentofExperimentalTherapeutics,TheUniversityofTexasMDAndersonCancerCenter,Houston,Tx,USA

Personaldata:DateofBirth:March21,1978/PlaceofBirth:Graz,Austria/Nationality:AustrianChildren:Amadea(3)

Education:2000-2006(6thMarch)MDgraduationattheMedicalUniversityofGraz,Austria2004-2009MasterofScienceinstudiesofMolecularBiologyattheKarl-Franzens-UniversityGraz,AustriaCareerHistory:2006–2007 15monthsPostdoctraining,InstituteofPathology,MedicalUniversityofGraz,Austria2007–2013 ResidentinInternalMedicine,SubspecialtyTraininginOncology,DivisionofOncology,

MedicalUniversityofGraz,Austria2013–2015 Assistant Professor (“Tenure track”), Division of Oncology, Medical University of Graz,

Austria2013–2015 ResearchFellowattheDepartmentofExperimentalTherapeutics,TheUniversityofTexas MDAndersonCancerCenter,Houston,Texas,USA(Prof.GeorgeA.Calin)2015 HabilitationinInternalMedicine(“MicroRNAsincolorectalcancer”)2015 BoardCertificationin“InternalMedicine”since11/2015 AdjunctAssistantProfessorattheDepartmentofExperimentalTherapeutics,

TheUniversityofTexas,MDAndersonCancerCenter,HoustonUSAsince01/2016 AssociateProfessor,DivisionofOncology,MedicalUniversityofGrazsince01/2016 HeadoftheResearchUnitfornon-codingRNAsandGenomeeditinginCancer,Grazsince05/2016 ResearchManagingDirector,DivisionofOncology,MedicalUniversityofGraz

AwardsandDistinctions(12selectedfrom23awards/sholarships):2015 (1)ErwinWenzlPrize,(2)OTMAR-PEISCHL-Prize,(3)SanofiAventisAward,(4)Besttalk

InternationalStudentCongress,(5)BestdiplomathesishonoredbyScientificSocietyofStyrianPhysicians(allawardsasSupervisor/Seniorauthor)

2014 Bestpublishinggroupleaderunderageof402012/2013attheCenterofMedicalResearch,MUG2014 WolfgangDenkPrize(SeniorAuthor)2013 (1)Sanofi-AventisPrize(First-author),(2)ResearcheroftheyearMedicalUniversityofGraz,Austria2012 (1)FWF-Erwin-SchrödingerScholarship,(2)HansandBlancaMoserAward2009 Ing.FriedrichSchmiedlAwardforbestdiplomathesis

Editorialresponsibilities:EditorialBoardMemberin3peer-reviewedjournals(e.g.InternationalJournalofMolecularSciences)

Invitedreviewerfor:Reviewerforscientificjournals(morethan60peer-reviewjournals)Reviewerforseveralgrantinstitutions(e.g.CancerResearchUK)




APPENDIX1

Curriculumvitae Name

WolfgangSattler,Assoc.-Prof.MSci,PhD

Affiliation:InstituteofMolecularBiologyandBiochemistryMedicalUniversityofGraz

Personaldata:DateofBirth:May271959/PlaceofBirth:Innsbruck,Austria/Nationality:AustrianChildren:Max(23)&Jakob(18)

Education:1979-1981 CollegeforChemicaltechnicians1984-1991 StudyofChemistry,UniversityofGraz,Austria1989-1991 PhDinChemistry,DepartmentofBiochemistry,Univ.Graz,Austria

CareerHistory:1981-1982 ChemicalTechnician,TechnicalUniversityMunich,Germany1982-1988 ChemicalTechnician,InstituteofBiochemistry,Univ.Graz,Austriay1989 Mag.rer.nat.,Chemistry1991 Dr.rer.nat.,Chemistry1991-1993 Post.Doc.,TheHeartResearchInstitute,Sydney,Australia1993 AssistantProf.,InstituteofMedicalBiochemistry,UniversityofGraz1997 HabilitationinMedicalBiochemistry1997-present AssociateProfessor,Inst.MolecularBiology&Biochemistry,MedicalUniv,Graz2010-present Speaker of the key research area ‘Molecular basis of lipid associated diseases’ at

the Medical University of Graz

AwardsandDistinctions:1991 YoungInvestigatorAwardfromKunerPty.Ltd1991 Erwin-SchrödingerFellowship,AustrianScienceFund(FWF)1997 AustrianCancerFoundation/StyriaAward2002 AventisPharmaAustriaAward2003 AventisPharmaAustriaAward2008 PhoenixPharmacyAward Invitedreviewerfor:Journals:ATVB,BBALipids,Curr.Org.Chem.,Bioechem.Pharmacol.,J.Neurochem.,Oncotarget,SciRep&othersGrantoffices:Austria,Germany,France,Canada,USA

Funding: overall3.404k€

Patents: 1patent(EP2297311)




APPENDIX1

CurriculumvitaeName

MichaelR.Speicher,Univ.-Prof.Dr.med.Dipl.-Inform.

Affiliation:Univ.-Prof.&Chair,InstituteofHumanGeneticsMedicalUniversityofGraz

Personaldata:DateofBirth:October25,1960/PlaceofBirth:Gladbeck,Germany/Nationality:GermanChildren:Alexander(22)&Julia(20)

Education:1980-1985 StudyofComputerScience,UniversityofDortmund,Germany1985 MasterofScienceinComputerScience1981-1988 StudyofMedicine,UniversityofEssen,Germany(withseveralsemestersabroad)1988 AmericanMedicalExamination(ECFMG),BasicandClinicalSciences

CareerHistory:1988-1990 InternalMedicine(Oncology)UniversityofEssen,Germany1991-1994 UniversityofHeidelberg,DepartmentofHumanGenetics,Germany(Lab.ofT.Cremer)1994-1996 YaleUniversity,SchoolofMedicine,DepartmentofGenetics(LaboratoryofDavidWard),

NewHaven,CT,USA1997-2001 HeadoftheFISHtechnologylaboratoryattheInstituteofAnthropologyandHuman

GeneticsattheLudwig-MaximilliansUniversityinMunich,Germany2000 Postdoctorallecturequalification(„Habilitation“):Thecoloredgenome,multicolorFISHin

clinicalapplications,UniversityofMunich2000 Boardsinmedicalandclinicalgenetics2001-2005 ViceDirectoroftheInstituteofHumanGeneticsattheTechnicalUniversityinMunich,

Germany2006-present ChairoftheInstituteofHumanGeneticsattheMedicalUniversityofGraz

AwardsandDistinctions:1997 ScientificawardoftheGermanSocietyofHumanGenetics2005 MunichBusinessPlancompetitionoftheTechnicalUniversityMunich(3rdplace):Business

idea“Singlecelltechnologies”

Editorialresponsibilities(selection):HumanGenetics,4thEdition,SpringerPublisher(formereditors:Vogel/Motulsky;currenteditors:

Speicher/Antonarakis/Motulsky),published20102006-2016:Editorof„MedizinischeGenetik“(OfficialorganoftheGerman,Austrian,andSwissSocietiesof

HumanGenetics,publishedbySpringerPublisher)(since2006)Since2014:EditorialboardofGenomeMedicineInvitedreviewerfor:Journals:Science, NatBiotech,NatCommun,NatGenet,NatMethods,NatProtoc,PNAS&othersGrantoffices:Austria,CzechRepublic,Germany,Netherlands,Finland,Belgium,Switzerland,UK


Patents: 8patents(4xUS,2xEU,1xGermany,1xAustralian)



APENDIX2:10mostrelevantpublicationswithauthorleadofeachmember


APPENDIX2

EvaBERNHART: 10publicationswithleadingauthorshipthataremostrelevanttothisprojectsince2005

1. Koyani,C.N.,Kitz,K.,Rossmann,C.,Bernhart,E.,Huber,E.,Trummer,C.,Windischhofer,W.,Sattler,

W.,Malle,E.ActivationoftheMAPK/Akt/Nrf2-Egr1/HO-1-GCLcaxisprotectsMG-63osteosarcomacellsagainst15d-PGJ2-mediatedcelldeath.BiochemPharmacol.2016;104(2):29-41

2. Nusshold, C.,Üllen,A., Kogelnik,N.,Bernhart, E., Reicher,H., Plastira, I.,Glasnov, T., Zangger, K.,Rechberger, G., Kollroser, M., Fauler, G., Wolinski, H., Weksler, BB., Romero, IA., Kohlwein, SD.,Couraud, P.O., Malle, E., Sattler, W. Assessment of electrophile damage in a human brainendothelialcelllineutilizingaclickablealkyneanalogof2-chlorohexadecanal.FreeRadicBiolMed.2016;90:59-74

3. Bernhart,E.,Damm,S.,Wintersperger,A.,Nusshold,C.,Brunner,AM.,Plastira, I.,Rechberger,G.,Reicher, H., Wadsack, C., Zimmer, A., Malle, E., Sattler, W. Interference with distinct steps ofsphingolipid synthesis and signaling attenuates proliferation of U87MG glioma cells. BiochemPharmacol.2015;96(2):119-130

4. Üllen,A.,Nusshold,C.,Glasnov,T.,Saf,R.,Cantillo,D.,Eibinger,G.,Reicher,H.,Fauler,G.,Bernhart,E.,Hallstrom, S., Kogelnik,N., Zangger, K.,OliverKappe,C.,Malle, E., Sattler,W.Covalent adductformation between the plasmalogen-derived modification product 2-chlorohexadecanal andphloretin.BiochemPharmacol.2015;93(4):470-481

5. Bernhart, E., Damm, S., Heffeter, P., Wintersperger, A., Asslaber, M., Frank, S., Hammer, A.,Strohmaier, H., Devaney, T., Mrfka, M., Eder, H., Windpassinger, C., Ireson, CR., Mischel, P.S.,Berger, W., Sattler, W. Silencing of protein kinase D2 induces glioma cell senescence via p53-dependentand-independentpathways.NeuroOncol.2014

6. Lohberger, B., Rinner, B., Stuendl, N., Kaltenegger, H., Steinecker-Frohnwieser, B., Bernhart, E.,Bonyadirad, E., Weinberg, A.M., Leithner, A., Bauer, R., Kretschmer, N. Sesquiterpene lactonesdownregulate G2/M cell cycle regulator proteins and affect the invasive potential of human softtissuesarcomacells.PLoSOne.2013;8(6):e66300-e66300

7. Bernhart,E.,Damm,S.,Wintersperger,A.,DeVaney,T.,Zimmer,A.,Raynham,T.,Ireson,C.,Sattler,W.ProteinkinaseD2regulatesmigrationandinvasionofU87MGglioblastomacellsinvitro.ExpCellRes.2013;319(13):2037-2048

8. Eibinger, G., Fauler, G.,Bernhart, E., Frank, S., Hammer, A.,Wintersperger, A., Eder, H.,Mischel,P.S., Malle, E., Sattler, W. Cholesterol 25-hydroxylase and 25-hydroxycholesterol production byglioblastomacelllinesisupregulatedbycytokines.ExpCellRes.2013;319(12):1828-1838

9. Bernhart, E., Kollroser,M., Rechberger, G., Reicher, H., Heinemann, A., Schratl, P., Hallström, S.,Wintersperger,A.,Nusshold,C.,Devaney,T.,Zorn-Pauly,K.,Malli,R.,Graier,W.,Malle,E.,Sattler,W.LysophosphatidicacidreceptoractivationaffectstheC13NJmicrogliacelllineproteomeleadingtoalterationsinglycolysis,motility,andcytoskeletalarchitecture.Proteomics.2010;10(1):141-158

10. Nusshold,C.,Kollroser,M.,Köfeler,H.,Rechberger,G.,Reicher,H.,Üllen,A.,Bernhart,E.,Waltl,S.,Kratzer, I.,Hermetter,A.,Hackl,H.,Trajanoski, Z.,Hrzenjak,A.,Malle,E., Sattler,W.Hypochloritemodification of sphingomyelin generates chlorinated lipid species that induce apoptosis andproteome alterations in dopaminergic PC12 neurons in vitro. Free Radic BiolMed. 2010; 48(12):1588-1600


APPENDIX2

RuthBIRNER-GRÜNBERGER: 10publicationswithleadingauthorshipthataremostrelevanttothisprojectsince2005

1. Tomazic,P.V.,Birner-Gruenberger,R.(cofirst/corresponding),Leitner,A.,Spoerk,S.&Lang-Loidolt,D.Seasonalproteomechangesofnasalmucusreflectperennialinflammatoryresponseandreduceddefencemechanismsandplasticityinallergicrhinitis.JProteomics133,153-160(2016).

2. Schittmayer,M.,Fritz,K.,Liesinger,L.,Griss,J.&Birner-Gruenberger,R.CleaningouttheLitterboxofProteomicScientists'FavoritePet:OptimizedDataAnalysisAvoidingTrypsinArtifacts.JProteomeRes15,1222-1229(2016).

4. Birner-Gruenberger,R.&Breinbauer,R.TrackingproteinS-fattyacylationwithproteomics.Chembiochem(2016).

5. Sahu-Osen,A.etal.CGI-58/ABHD5isphosphorylatedonSer239byproteinkinaseA:controlofsubcellularlocalization.JLipidRes56,109-121(2015).

6. Birner-Gruenberger,R.,Schittmayer,M.,Holzer,M.&Marsche,G.Understandinghigh-densitylipoproteinfunctionindisease:Recentadvancesinproteomicsunravelthecomplexityofitscompositionandbiology.ProgLipidRes56C,36-46(2014).

7. Kumari,M.etal.AdiponutrinFunctionsasaNutritionallyRegulatedLysophosphatidicAcidAcyltransferase.CellMetabolism15,691-702(2012).

8. Birner-Gruenberger,R.etal.FunctionalfatbodyproteomicsandgenetargetingrevealinvivofunctionsofDrosophilamelanogasteralpha-Esterase-7.InsectBiochemistryandMolecularBiology42,220-229(2012).

9. Birner-Gruenberger,R.,Susani-Etzerodt,H.,Kollroser,M.,Rechberger,G.N.&Hermetter,A.Lipolyticandesterolyticactivity-basedprofilingofmurineliver.Proteomics8,3645-3656(2008).

10. Birner-Gruenberger,R.etal.Thelipolyticproteomeofmouseadiposetissue.MolCellProteomics4,1710-1717(2005).


APPENDIX2

JulianeG.Bogner-Strauss(neeStrauss):10mostrelevantpublicationssince2004

1. HoferD,PessentheinerAR,PelzmannHJ,SchlagerS,Madreiter-SokolowskiC,KolbD,RechbergerG,GraierW,KratkyD,andBogner-StraussJG.PEX16-mediatedperoxisomedenovosynthesisisrequiredforadipogenesisandPPARγactivation.SciRep.Revisedversionsubmitted

2. ProkeschA,PelzmannHJ,PessentheinerAR,HuberK,Madreiter-SokolowskiCT,DrougardA,SchittmayerM,KolbD,MagnesC,TrausingerG,GraierWF,Birner-GruenbergerR,PospisilikJA,Bogner-StraussJG.N-acetylaspartatecatabolismdeterminescytosolicacetyl-CoAlevelsandhistoneacetylationinbrownadipocytes.SciRep.2016Apr5;6:23723.

3. OhDY,WalentaE,AkiyamaRE,LagakosWS,LackeyD,PessentheinerAR,SasikR,HahN,ChiT,CoxJM,PowelsMA,DiSalvoJ,SinzC,WatkinsSM,ArmandoAM,ChungH,EvansRM,QuehenbergerO,McNelisJ,Bogner-StraussJG,OlefskyJM.AGpr120SelectiveAgonistImprovesInsulinResistanceandChronicInflammation.NatureMedicine2014,20(8):942-947.

4. ProkeschA,SmorlesiA,PeruginiJ,ManieriM,CiarmelaP,MondiniE,TrajanoskiZ,KristiansenK,GiordanoA,Bogner-StraussJG*,andCintiS*(*correspondingauthors).MolecularAspectsofAdipo-epithelialTransdifferentiationinMouseMammaryGland.StemCells.StemCells.2014,32(10):2756-2766.

5. PessentheinerAR,PelzmannHJ,WalentaE,SchweigerM,GroschnerLN,GraierWF,KolbD,UnoK,MiyazakiT,NittaA,RiederD,ProkeschA,Bogner-StraussJG.N-acetyltransferase8-likeimpactsonbrownadipocytedevelopmentandenhancesmetabolicrate.JBiolChem.2013Dec13;288(50):36040-51PMID:24155240

6. WalentaE,PessentheinerAR,PelzmannHJ,DeutschA,GoeritzerM,KratkyD,HacklH,OhDY,ProkeschA,Bogner-StraussJG.a/ß-HydrolaseDomainContainingProtein15(ABHD15)–anAdipogenicProteinProtectingfromApoptosis.PLoSOne.2013Nov13;8(11):e79134PMID:24236098

7. PinentM,ProkeschA,HacklH,VosholPJ,KlatzerA,WalentaE,PanzenboeckU,KennerL,TrajanoskiZ,HoeflerGandBogner-StraussJG.AdiposetriglyceridelipaseisinvolvedinfatlossinJunB-deficient.Endocrinology.2011Jul;152(7):2678-2689.

8. ProkeschA*,Bogner-StraussJG*,RiederD,NeuholdC,HacklH,KrogsdamA,ScheidelerM,PapakC,WongW-C,VinsonC,EisenhaberFandTrajanoskiZ.(*contributedequally).Arxes:Retrotransposedgenesrequiredforadipogenesis.NucleicAcidResearch.201139(8):3224-3239.

9. Bogner-StraussJG*,ProkeschA,Sanchez-CaboF,RiederD,HacklH,DuszkaK,KrogsdamA,DiCamilloB,WalentaE,KlatzerA,LassA,PinentM,WongWC,EisenhaberF,TrajanoskiZ.(*correspondingauthor).ReconstructionofgeneassociationnetworkrevealsatransmembraneproteinrequiredforadipogenesisandtargetedbyPPARγ.CellMolLifeSci.2010,67(23):4049-4064.

10. ZimmermannR*,StraussJG*,HaemmerleG,SchoiswohlG,Birner-GruenbergerR,RiedererM,LassA,NeubergerG,EisenhaberF,HermetterA,ZechnerR.(*equalcontribution).Fatmobilizationinadiposetissueispromotedbyadiposetriglyceridelipase.Science.2004Nov19;306(5700):1383-1386.


APPENDIX2

TobiasEisenberg: 10publicationswithleadingauthorshipthataremostrelevanttothisprojectsince2005

1. Madeo,F.,Pietrocola,F.,Eisenberg,T.&Kroemer,G.Caloricrestrictionmimetics:towardsamoleculardefinition.NatRevDrugDiscov13,727–740(2014)

2. Eisenberg,T.etal.Ahistonepointmutationthatswitchesonautophagy.Autophagy10,1143–1145(2014)

3. Mariño,G.etal.Regulationofautophagybycytosolicacetyl-coenzymea.Mol.Cell53,710–725(2014)

4. Eisenberg,T.etal.Nucleocytosolicdepletionoftheenergymetaboliteacetyl-coenzymeastimulatesautophagyandprolongslifespan.CellMetab.19,431–444(2014)

5. Eisenberg,T.&Büttner,S.Lipidsandcelldeathinyeast.FEMSYeastRes.(2013).doi:10.1111/1567-1364.12105

6. Gupta,V.K.etal.Restoringpolyaminesprotectsfromage-inducedmemoryimpairmentinanautophagy-dependentmanner.Nat.Neurosci.16,1453–1460(2013)

7. Galluzzi,L.etal.PrognosticimpactofvitaminB6metabolisminlungcancer.CellRep2,257–269(2012)

8. Breitenbach,M.etal.Theroleofmitochondriaintheagingprocessesofyeast.Subcell.Biochem.57,55–78(2012)

9. Eisenberg,T.etal.Inductionofautophagybyspermidinepromoteslongevity.Nat.CellBiol.11,1305–1314(2009)

10. Eisenberg,T.,Büttner,S.,Kroemer,G.&Madeo,F.Themitochondrialpathwayinyeastapoptosis.Apoptosis12,1011–1023(2007)


APPENDIX2

WolfgangF.GRAIER: 10publicationswithleadingauthorshipthataremostrelevanttothisprojectsince2005

1. Waldeck-Weiermair,M.,Malli,R.,Parichatikanond,W.,Gottschalk,B.,Madreiter-Sokolowski,C.T.,Klec,C.,Rost,R.&Graier,W.F..RearrangementofMICU1multimersforactivationofMCUissolelycontrolledbycytosolicCa2+.Sci.Rep.5:15602,20152015

2. Bondarenko,A.I.,Parichatikanond,W.,Madreiter,C.T.,Rost,R.,Waldeck-Weiermair,M.,Malli,R.&Graier,W.F..UCP2modulatessinglechannelpropertiesofaMCU-dependentCa2+inwardcurrentinmitochondria.PflügersArch.–Eur.J.Physiol.467:2509-25018,2015

3. Bondarenko,A.I.,Jean-Quartier,C.,Parichatikanond,W.,Alam,M.R.,Waldeck-Weiermair,M.,Malli,R.,&Graier,W.F.MitochondrialCa2+uniporter(MCU)-dependentand-independentCa2+channelscoexistintheinnermitochondrialmembrane.PflügersArch.–Eur.J.Physiol.466:1411-1420,2014

4. Waldeck-Weiermair,M.,Deak,A.T.,Groschner,L.N.,Alam,M.R.,Jean-Quartier,C.,Malli,R.&Graier,W.F.MolecularlydistinctroutesofmitochondrialCa2+uptakeareactivateddependingontheactivityofthesarco/endoplasmicreticulumCa2+ATPase(SERCA).J.Biol.Chem.288:15367-15379,2013

5. Bondarenko,A.I.,Jean-Quartier,C.,Malli,R.&Graier,W.F.CharacterizationofdistinctsinglechannelpropertiesofCa2+inwardcurrentsinmitochondria.PflügersArch.–Eur.J.Physiol.465:997-1010,2013

6. Alam,M.R.Groschner,L.N.,Parichatikanond,W.,Kuo,L.,Bondarenko,A.I.,Rost,R.,Waldeck-Weiermair,M.,Malli,R.&Graier,W.F.MitochondrialCa2+uptake1(MICU1)andmitochondrialCa2+uniporter(MCU)contributetometabolism-secretioncouplinginclonalpancreaticß-cells.J.Biol.Chem.287:34445-34454,2012

7. Waldeck-Weiermair,M.,Jean-Quartier,C.,Rost,R.,Khan,M.J.,Vishnu,N.,Bondarenko,A.I.,Imamura,H.,Malli,R.&Graier,W.F.TheleucinezipperEFhand-containingtransmembraneprotein1(LETM1)anduncouplingproteins-2and3(UCP2/3)contributetotwodistinctmitochondrialCa2+uptakepathways.J.Biol.Chem.286:28444-28455,2011

8. Waldeck-Weiermair,M.,Duan,X.,Naghdi,S.,Khan,M.J.,Trenker,M.,Malli,R.&Graier,W.F.Uncouplingprotein3adjustsmitochondrialCa2+uptaketohighandlowCa2+signals.CellCalcium48:288-301,2010

9. Trenker,M.,Malli,R.,Fertschai,I.,Levak-Frank,S.,andGraier,W.F.Uncoupling-proteins2and3areelementaryformitochondrialCa2+uniport.Nat.Cell.Biol.9:445-452,2007

10. Malli,R,Frieden,M.,Trenker,M.andGraier,W.F.TheroleofmitochondriaforCa2+refillingoftheER.J.Biol.Chem.280:12114-12122,2005


APPENDIX2

GuenterHaemmerle: 10mostrelevantpublicationsforthisprojectsince2005

1. Heier,CandHaemmerle,G.Fatintheheart:Theenzymaticmachineryregulatingcardiactriacylglycerolmetabolism.BiochimBiophysActa.16:1388-1981,2016

2. Jaeger,D.,Schoiswohl,G.,Hofer,P.,Schreiber,R.,Schweiger,M.,Eichmann,T.O.,Pollak,N.M.,Poecher,N.,Grabner,G.F.,Zierler,K.A.,Eder,S.,Kolb,D.,Radner,F.P.W.,Preiss-Landl,K.,Lass,A.,Zechner,R.,Kershaw,E.E.,andHaemmerle,G.Fasting-inducedG0/G1switchgene2andFGF21expressionintheliverareunderregulationofadiposetissuederivedfattyacids.J.Hepatol.63:437–45,2015

3. Pollak,N.M.,Jaeger,D.,Kolleritsch,S.,Zimmermann,R.,Zechner,R.,Lass,A.,andHaemmerle,G.TheinterplayofproteinkinaseAandperilipin5regulatescardiaclipolysis.J.Biol.Chem.290:1295–306,2015

4. Brahma,M.K.,Adam,R.C.,Pollak,N.M.,Jaeger,D.,Zierler,K.A.,Pöcher,N.,Schreiber,R.,Romauch,M.,Moustafa,T.,Eder,S.,Ruelicke,T.,Preiss-Landl,K.,Lass,A.,Zechner,R.,andHaemmerle,G.Fibroblastgrowthfactor21isinduceduponcardiacstressandalterscardiaclipidhomeostasis.J.LipidRes.55:2229–41,2014

5. Zierler,K.A.,Jaeger,D.,Pollak,N.M.,Eder,S.,Rechberger,G.N.,Radner,F.P.W.,Woelkart,G.,Kolb,D.,Schmidt,A.,Kumari,M.,Preiss-Landl,K.,Pieske,B.,Mayer,B.,Zimmermann,R.,Lass,A.,Zechner,R.,andHaemmerle,G.Functionalcardiaclipolysisinmicecriticallydependsoncomparativegeneidentification-58.J.Biol.Chem.288:9892–904,2013

6. Pollak,N.M.,Schweiger,M.,Jaeger,D.,Kolb,D.,Kumari,M.,Schreiber,R.,Kolleritsch,S.,Markolin,P.,Grabner,G.F.,Heier,C.,Zierler,K.A.,Rülicke,T.,Zimmermann,R.,Lass,A.,Zechner,R.,andHaemmerle,G.Cardiac-specificoverexpressionofperilipin5provokesseverecardiacsteatosisviatheformationofalipolyticbarrier.J.LipidRes.54:1092–102,2013

7. Haemmerle,G.,Moustafa,T.,Woelkart,G.,Büttner,S.,Schmidt,A.,vandeWeijer,T.,Hesselink,M.,Jaeger,D.,Kienesberger,P.C.,Zierler,K.,Schreiber,R.,Eichmann,T.,Kolb,D.,Kotzbeck,P.,Schweiger,M.,Kumari,M.,Eder,S.,Schoiswohl,G.,Wongsiriroj,N.,Pollak,N.M.,Radner,F.P.W.,Preiss-Landl,K.,Kolbe,T.,Rülicke,T.,Pieske,B.,Trauner,M.,Lass,A.,Zimmermann,R.,Hoefler,G.,Cinti,S.,Kershaw,E.E.,Schrauwen,P.,Madeo,F.,Mayer,B.,andZechner,R.ATGL-mediatedfatcatabolismregulatescardiacmitochondrialfunctionviaPPAR-αandPGC-1.Nat.Med.17:1076–85,2011

8. Das,S.K.,Eder,S.,Schauer,S.,Diwoky,C.,Temmel,H.,Guertl,B.,Gorkiewicz,G.,Tamilarasan,K.P.,Kumari,P.,Trauner,M.,Zimmermann,R.,Vesely,P.,Haemmerle,G.,Zechner,R.,andHoefler,G.Adiposetriglyceridelipasecontributestocancer-associatedcachexia.Science333:233–8,2011

9. Radner,F.P.W.,Streith,I.E.,Schoiswohl,G.,Schweiger,M.,Kumari,M.,Eichmann,T.O.,Rechberger,G.,Koefeler,H.C.,Eder,S.,Schauer,S.,Theussl,H.C.,Preiss-Landl,K.,Lass,A.,Zimmermann,R.,Hoefler,G.,Zechner,R.,andHaemmerle,G.Growthretardation,impairedtriacylglycerolcatabolism,hepaticsteatosis,andlethalskinbarrierdefectinmicelackingcomparativegeneidentification-58(CGI-58).J.Biol.Chem.285:7300–11,2010

10. Haemmerle,G.,Lass,A.,Zimmermann,R.,Gorkiewicz,G.,Meyer,C.,Rozman,J.,Heldmaier,G.,Maier,R.,Theussl,C.,Eder,S.,Kratky,D.,Wagner,E.F.,Klingenspor,M.,Hoefler,G.,andZechner,R.(2006)Defectivelipolysisandalteredenergymetabolisminmicelackingadiposetriglyceridelipase.Science312:734–7,2006


APPENDIX2

TobiasMadl: 10publicationswithleadingauthorshipthataremostrelevanttothisprojectsince2005

1. GöblC.,MadlT.(co-corresponding&sharedfirstauthor),SimonB.,SattlerM.,NMRapproachesforstructuralanalysisofmultidomainproteinsandcomplexesinsolution.Progr.NMRSpectroscopy80:26,2014

2. LorenzO.,FreiburgerF.,RutzD.,KrauseM.,ZiererB.,AlviraA.,CuéllarJ.,ValpuestaJ.M.,MadlT.(co-correspondingauthor),SattlerM.,BuchnerJ.,ModulationoftheHsp90chaperonecyclebyastringentclientprotein.Mol.Cell.53:941,2014.

3. KaragözG.E.,DuarteA.M.S.,AkouryE.,IppelH.,BiernatJ.,LuengoT.M.,RadliM.,DidenkoT.,NordhuesB.A.,VeprintsevD.P.,DickeyC.,MandelkowE.,ZweckstetterM.,BoelensR.,MadlT.(co-correspondingauthor),RüdigerS.G.D.,Hsp90-Taucomplexrevealsmolecularbasisforspecificityinchaperoneaction.Cell156:963,2014.

4. ZhangY.,MadlT.(sharedfirstauthor,co-correspondingauthor),BagdiulI.,KernT.KangH.-S.,ZouP.,MäusbacherN.,SieberS.A.,KrämerA.,SattlerM.,Structure,phosphorylationandU2AF65bindingoftheN-terminaldomainofsplicingfactor1during3’splicesiterecognition.NucleicAcidsRes.41:1343,2013.

5. MadlT.,GüttlerT.,GörlichD.,SattlerM.,StructuralAnalysisofLargeProteinComplexesusingSolventParamagneticRelaxationEnhancements.Angew.Chemie50:3993,2011.

6. GüttlerT.,MadlT.(sharedfirstauthor),NeumannP.,DeichselD.,CorsiniL.,MoneckeT.,FicnerR.,SattlerM.,GörlichD.,StructuralbasisfortherecognitionofdiversenuclearexportsignalsbytheexportinCRM1,Nat.Struct.Mol.Biol.17:1367,2010

7. MadlT.,FelliI.C.,BertiniI.,SattlerM.,Structuralanalysisofproteininterfacesfrom13Cdirect-detectedparamagneticrelaxationenhancements,J.Am.Chem.Soc.132:7285,2010.

8. MadlT.,BermelW.,ZanggerK.,UseofRelaxationEnhancementsinaParamagneticEnvironmentfortheStructureDeterminationofProteinsUsingNMRSpectroscopy,Angew.Chemie48:8259,2009.

9. MadlT.,VanMelderenL.,MineN.,RespondekM.,ObererM.,KellerW.,KhataiL.,ZanggerK.,StructuralbasisfornucleicacidandtoxinrecognitionofthebacterialantitoxinCcdA,J.Mol.Biol.364:170,2006.

10. MadlT.(correspondingauthor),SterkH.,RechbergerG.N.,MittelbachM.,TandemmassspectrometricanalysisofacomplextriterpenesaponinmixtureofChenopodiumquinoa,J.Am.Soc.MassSpectrom.17:795,2006.


APPENDIX2

RolandMALLI: 10publicationswithleadingauthorshipthataremostrelevanttothisprojectsince2005

1. Eroglu,E.,Gottschalk,B.,Charoensin,S.,Blass,S.,Bischof,H.,Rost,R.,Madreiter-Sokolowski,C.T.,Pelzmann,B.,Bernhart,E.,Sattler,W.,Hallström,S.,Malinski,T.,Waldeck-Weiermair,M.,Graier,W.F. & Malli, R. Development of novel FP-based probes for live-cell imaging of nitric oxidedynamics.Nat.Commun.7:10623,2016

2. Waldeck-Weiermair, M., Bischof, H., Blass, S., Deak, A., Klec, C., Graier, T., Roller, C., Rost, R.,Eroglu, E., Gottschalk, B., Hofmann, N., Graier, W.F. & Malli, R. Generation of red-shiftedcameleons for imaging Ca2+ dynamics of the endoplasmic reticulum. Biosensors Biosensors 15:13052-13068,2015

3. Deak,A.T.,Blass,S.,Khan,M.J.,Groschner,L.N.,Waldeck-Weiermair,M.,Hallström,S.,Graier,W.F.& Malli, R. Inositol-1,4,5-trisphosphate (IP3)-mediated STIM1 oligomerization requires intactmitochondrialCa2+uptake.J.Cell.Sci.127:2944-2955,2014

4. Vishnu,N.,Khan,M.J.,Karsten,F.,Groschner,L.N.,Waldeck-Weiermair,M.,Rost,R.,Hallström,S.,Imamura,H.,Graier,W.F.&Malli,R.ATPIncreaseswithintheLumenoftheEndoplasmicReticulumUponIntracellularCa2+-Release.Mol.Biol.Cell.25:368-379,2014

5. Deak, A.T., Groschner, L.N., Alam,M.R., Seles, E., Bondarenko, A.I., Graier,W.F. &Malli, R. TheendocannabinoidN-arachidonoylglycine (NAGly) inhibits store-operatedCa2+entrybypreventingSTIM1/Orai1interaction.J.Cell.Sci.126:879-888,2013

6. Waldeck-Weiermair, M., Alam, M.R., Khan, M.J., Deak, A., Vishnu, N., Karsten, F., Imamura, H.,Graier, W.F. &Malli, R. Spatiotemporal correlations between cytosolic and mitochondrial Ca2+signalsusinganovelred-shiftedmitochondrialtargetedcameleon.PLOSone7(9):e45917,2012

7. Khan, M.J., Alam, M.R., Waldeck-Weiermair, M., Karsten, F., Groschner, L., Riederer, M.,Hallstroem, S., Rockenfeller, P., Konya, V., Heinemann, A., Madeo, F., Graier, W.F., &Malli, R.Inhibition of autophagy rescues palmitic acid induced necroptosis of endothelial cells. Journal ofBiologicalChemistry287:21110-21120,2012

8. Malli, R., Shamim Naghdi, S., Romanin, C. and Graier, W.F. Cytosolic Ca2+ prevents thesubplasmalemmal clusteringof STIM1:an intrinsicmechanism toavoidCa2+overload. J.Cell. Sci.121:3133-3139,2008

9. Malli,R.,Frieden,M.,Hunkova,M.,Trenker,M.andGraier,W.F.Ca2+refillingoftheendoplasmicreticulumislargelypreservedalbeitreducedCa2+entryinendothelialcells.CellCalcium41:63-76,2007

10. Malli,R,Frieden,M.,Trenker,M.andGraier,W.F.TheroleofmitochondriaforCa2+refillingoftheER.J.Biol.Chem.280:12114-12122,2005


APPENDIX2

MartinPichler: 10publicationswithleadingauthorshipthataremostrelevanttothisprojectsince2005

1. Pichler,M.,Stiegelbauer,V.,Vychytilova-Faltejskova,P.,Ivan,C.,Ling,H.,Winder,E.,Zhang,X.,Wulf-Goldenberg,A.,Ohtsuka,M.,Haybaeck,J.,Svoboda,M.,Okugawa,Y.,Gerger,G.,Hoefler,G.,Goel,A.,Slaby,O.,Calin,Ga..Genome-widemicroRNAanalysisidentifiesmiR-188asnovelprognosticmarkerandmolecularfactorinvolvedincolorectalcarcinogenesis.ClinicalCancerResearch,inpress,2016

2. Pichler,M.,Calin,GA..MicroRNAsincancer:fromdevelopmentalgenesinwormstotheirclinicalapplicationinpatients.BrJCancer.113(4):569-573,2015

3. Ling,H.,Vincent,K.,Pichler,M.,Fodde,R.,Berindan-Neagoe,I.,Slack,FJ.,Calin,GA..JunkDNAandthelongnon-codingRNAtwistincancergenetics.Oncogene.Sep24;34(39):5003-11.2015

4. Schwarzenbacher,D.,Stiegelbauer,V.,Deutsch,A.,Ress,AL.,Aigelsreiter,A.,Schauer,S.,Wagner,K.,Langsenlehner,T.,Resel,M.,Gerger,A.,Ling,H.,Ivan,C.,Calin,GA.,Hoefler,G.,Rinner,B.,PichlerM..Lowspinophilinexpressionenhancesaggressivebiologicalbehaviorofbreastcancer.Oncotarget.May10;6(13):11191-202.2015

5. Ress,AL.,Stiegelbauer,V.,Winter,E.,Schwarzenbacher,D.,Kiesslich,T.,Lax,S.,Jahn,S.,Deutsch,A.,Bauernhofer,T.,Ling,H.,Samonigg,H.,Gerger,A.,Hoefler,G.,Pichler,M..MiR-96-5pinfluencescellulargrowthandisassociatedwithpoorsurvivalincolorectalcancerpatients.MolCarcinog.54(11):1442-1450,2015

6. Ress,AL.,Stiegelbauer,V.,Schwarzenbacher,D.,Deutsch,A.,Perakis,S.,Ling,H.,Ivan,C.,Calin,GA.,Rinner,B.,Gerger,A.,Pichler,M..Spinophilinexpressiondeterminescellulargrowth,cancerstemnessand5-flourouracilresistanceincolorectalcancer.Oncotarget.5(18):8492-8502.2014

7. Pichler,M.,Ress,AL.,Winter,E.,Stiegelbauer,V.,Karbiener,M.,Schwarzenbacher,D.,Scheideler,M.,Ivan,C.,Jahn,SW.,Kiesslich,T.,Gerger,A.,Bauernhofer,T.,Calin,GA.,Hoefler,G..MiR-200aregulatesepithelialtomesenchymaltransition-relatedgeneexpressionanddeterminesprognosisincolorectalcancerpatients.BrJCancer.110(6):1614-16212014

8. Szkandera,J.,Gerger,A.,Liegl-Atzwanger,B.,Absenger,G.,Stotz,M.,Friesenbichler,J.,Trajanoski,S.,Stojakovic,T.,Eberhard,K.,Leithner,A.,Pichler,M..Thelymphocyte/monocyteratiopredictspoorclinicaloutcomeandimprovesthepredictiveaccuracyinpatientswithsofttissuesarcomas.IntJCancer.135(2):362-3702014

9. Heitzer*,E.,Auer,M.,Gasch,C.,Pichler*,M.,Ulz,P.,Hoffmann,EM.,Lax,S.,Waldispuehl-Geigl,J.,Mauermann,O.,Lackner,C.,Höfler,G.,Eisner,F.,Sill,H.,Samonigg,H.,Pantel,K.,Riethdorf,S.,Bauernhofer,T.,Geigl,JB.,Speicher,MR..Complextumorgenomesinferredfromsinglecirculatingtumorcellsbyarray-CGHandnext-generationsequencing.*equallycontributedfirstauthorCancerRes.73(10):2965-29752013

10. Pichler,M.,Rainer,PP.,Schauer,S.,Hoefler,G..Cardiacfibrosisinhumantransplantedheartsismainlydrivenbycellsofintracardiacorigin.JAmCollCardiol.59(11):1008-1016.2012


APPENDIX2

WolfgangSATTLER: 10publicationswithleadingauthorshipthataremostrelevanttothisprojectsince2005

1. Nusshold,C.;Ullen,A.;Kogelnik,N.;Bernhart,E.;Reicher,H.;Plastira, I.;Glasnov,T.;Zangger,K.;Rechberger,G.; Kollroser,M.; Fauler,G.;Wolinski, H.;Weksler, B. B.; Romero, I. A.; Kohlwein, S. D.;Couraud,P.O.;Malle,E.;Sattler,W.Assessmentofelectrophiledamageinahumanbrainendothelialcelllineutilizingaclickablealkyneanalogof2-chlorohexadecanal.FreeRadicBiolMed90:59-74;2016.

2. Ullen, A.; Nusshold, C.; Glasnov, T.; Saf, R.; Cantillo, D.; Eibinger, G.; Reicher, H.; Fauler, G.;Bernhart, E.;Hallstrom, S.; Kogelnik,N.; Zangger, K.;Oliver Kappe, C.;Malle, E.; Sattler,W. Covalentadduct formation between the plasmalogen-derived modification product 2-chlorohexadecanal andphloretin.BiochemPharmacol93:470-481;2015.

3. Bernhart,E.;Damm,S.;Wintersperger,A.;Nusshold,C.;Brunner,A.M.;Plastira,I.;Rechberger,G.;Reicher, H.; Wadsack, C.; Zimmer, A.; Malle, E.; Sattler, W. Interference with distinct steps ofsphingolipid synthesis and signaling attenuates proliferation of U87MG glioma cells. BiochemPharmacol96:119-130;2015.

4. Bernhart, E.; Damm, S.; Heffeter, P.; Wintersperger, A.; Asslaber, M.; Frank, S.; Hammer, A.;Strohmaier,H.;DeVaney,T.;Mrfka,M.;Eder,H.;Windpassinger,C.;Ireson,C.R.;Mischel,P.S.;Berger,W.;Sattler,W.SilencingofproteinkinaseD2inducesgliomacellsenescenceviap53-dependentand-independentpathways.NeuroOncol16:933-945;2014.

5. Ullen, A.; Singewald, E.; Konya, V.; Fauler, G.; Reicher, H.; Nusshold, C.; Hammer, A.; Kratky, D.;Heinemann,A.;Holzer,P.;Malle,E.;Sattler,W.Myeloperoxidase-derivedoxidantsinduceblood-brainbarrierdysfunctioninvitroandinvivo.PLoSOne8:e64034;2013.

6. Nusshold, C.; Uellen, A.; Bernhart, E.; Hammer, A.; Damm, S.; Wintersperger, A.; Reicher, H.;Hermetter,A.;Malle,E.;Sattler,W.EndocytosisandintracellularprocessingofBODIPY-sphingomyelinbymurineCATH.aneurons.BiochimBiophysActa1831:1665-1678;2013.

7. Ullen,A.;Fauler,G.;Bernhart,E.;Nusshold,C.;Reicher,H.;Leis,H.J.;Malle,E.;Sattler,W.Phloretinameliorates 2-chlorohexadecanal-mediated brain microvascular endothelial cell dysfunction in vitro.FreeRadicBiolMed53:1770-1781;2012.

8. Ullen, A.; Fauler, G.; Kofeler, H.; Waltl, S.; Nusshold, C.; Bernhart, E.; Reicher, H.; Leis, H. J.;Wintersperger,A.;Malle,E.;Sattler,W.Mousebrainplasmalogensaretargetsforhypochlorousacid-mediatedmodificationinvitroandinvivo.FreeRadicBiolMed49:1655-1665;2010.

9. Nusshold,C.;Kollroser,M.;Kofeler,H.;Rechberger,G.;Reicher,H.;Ullen,A.;Bernhart,E.;Waltl,S.;Kratzer, I.; Hermetter, A.; Hackl, H.; Trajanoski, Z.; Hrzenjak, A.; Malle, E.; Sattler, W. HypochloritemodificationofsphingomyelingenerateschlorinatedlipidspeciesthatinduceapoptosisandproteomealterationsindopaminergicPC12neuronsinvitro.FreeRadicBiolMed48:1588-1600;2010.

10.Bernhart, E.; Kollroser,M.; Rechberger,G.; Reicher, H.; Heinemann, A.; Schratl, P.; Hallstrom, S.;Wintersperger,A.;Nusshold,C.;DeVaney,T.;Zorn-Pauly,K.;Malli,R.;Graier,W.;Malle,E.;Sattler,W.Lysophosphatidic acid receptor activation affects the C13NJ microglia cell line proteome leading toalterationsinglycolysis,motility,andcytoskeletalarchitecture.Proteomics10:141-158;2010.

APPENDIX2

MichaelR.SPEICHER: 10publicationswithleadingauthorshipthataremostrelevanttothisprojectsince2005

1. UlzP,ThallingerGG,AuerM,GrafR,KashoferK,JahnSW,AbeteL,PristauzG,PetruE,GeiglJB,HeitzerE,SpeicherMR.Inferringexpressedgenesbywhole-genomesequencingofplasmaDNA.NatGenet.2016,“acceptedforpublicationinprinciple”

2. UlzP,BelicJ,GrafR,AuerM,LaferI,FischerederK,WebersinkeG,PummerK,AugustinH,PichlerM,HoeflerG,BauernhoferT,GeiglJB,HeitzerE,SpeicherMR.Whole-genomeplasmasequencingrevealsfocalamplificationsasadrivingforceinmetastaticprostatecancer.Nat.Commun.7:12008,2016

3. UlzP,HeitzerE,SpeicherMR.Co-occurrenceofMYCamplificationandTP53mutationsinhumancancer.NatGenet.48:104-6,2016

4. MlecnikB,BindeaG,AngellHK,SassoMS,ObenaufAC,FredriksenT,LafontaineL,BilocqAM,KirilovskyA,TosoliniM,WaldnerM,BergerA,FridmanWH,RafiiA,Valge-ArcherV,PagèsF,SpeicherMR,GalonJ.Functionalnetworkpipelinerevealsgeneticdeterminantsassociatedwithinsitulymphocyteproliferationandsurvivalofcancerpatients.SciTranslMed.6:228ra37,2014

5. HeitzerE,AuerM,GaschC,PichlerM,UlzP,HoffmannEM,LaxS,Waldispuehl-GeiglJ,MauermannO,LacknerC,HöflerG,EisnerF,SillH,SamoniggH,PantelK,RiethdorfS,BauernhoferT,GeiglJB,SpeicherMR.Complextumorgenomesinferredfromsinglecirculatingtumorcellsbyarray-CGHandnext-generationsequencing.CancerRes.73:2965-75,2013

6. WiesnerT,FriedI,UlzP,StacherE,MuraliR,PopperH,KutznerH,LaxS,Smolle-JüttnerF,GeiglJB,SpeicherMR.TowardsanimproveddefinitionofthetumorspectrumassociatedwithBAP1germlinemutations.JClinOncol30:e337-40,2012

7. WiesnerT,ObenaufAC,MuraliR,FriedI,GriewankKG,UlzP,WindpassingerC,WackernagelW,LoyS,WolfI,VialeA,LashAE,PirunM,SocciND,RüttenA,PalmedoG,AbramsonD,OffitK,OttA,BeckerJC,CerroniL,KutznerH,BastianBC,SpeicherMR.GermlinemutationsinBAP1predisposetomelanocytictumors.NatGenet43:1018-21,2011

8. AleksicK,LacknerC,GeiglJB,SchwarzM,AuerM,UlzP,FischerM,TrajanoskiZ,OtteM,SpeicherMR.Evolutionofgenomicinstabilityindiethylnitrosamine-inducedhepatocarcinogenesisinmice.Hepatology53:895-904,2011

9. Begus-NahrmannY,LechelA,ObenaufAC,NalapareddyK,PeitE,HoffmannE,SchlaudraffF,LissB,SchirmacherP,KestlerH,DanenbergE,BarkerN,CleversH,SpeicherMR,RudolphKL.p53deletionimpairsclearanceofchromosomalinstablestemcellscompromisingintegrityoftheintestineinagingtelomeredysfunctionalmice.NatGenet41:1138-43,2009

10. GeiglJB,ObenaufAC,SchwarzbraunT,SpeicherMR.Defining'chromosomalinstability'.TrendsGenet24:64-69,2008

APENDIX3:Thecompletelistofgrantedprojectsforeachmember


APPENDIX3

EvaBERNHART:Fundingasleadapplicant

YEAR Agency Country:ProjectTitle(Number) Support(k€)

2015-2017 ÖNB A:InteratrialgradientsinIfandIK1andtheircontribution

tofocalactivityinatrialfibrillation

120


APPENDIX3

RuthBIRNER-GRÜNBERGER:Fundingasleadapplicant:

YEAR Agency Country:ProjectTitle(Number) Support(k€)2006-2007 FFG/Ministry A:GEN-AU:Clickit 1002009-2011 EU(EFRE) EU:Acquisitionofahighresolutionmassspectrometry

system800

2009-2012 FFG A:GOLD3:Discoveryoflipolyticenzymesbyinvivoproteomics(C5)

181

2011-2012 EC EU:Standardizationandimprovementofgenericpre-analyticaltoolsandproceduresforinvitro

52

2013-2016 FWF A:Hormonalregulationoflipolysis(P26074) 3532009-2014 FFG A:AustrianCentreofIndustrialBiotechnology(ACIB)

(824186)305

2010-2014 FWF A:DoctoralCollegeMetabolicandCardiovascularDisease(DK-MCD)(W1226)

342

2013-2018 Ministry A:OmicsCenterGraz 15402014-2018 FWF A:DoctoralCollegeMetabolicandCardiovascularDisease

(DK-MCD)(W1226)350

2015-2020 FFG A:AustrianCentreofIndustrialBiotechnology(ACIB)(824186)

287

2006-2016 4663

APPENDIX3

JulianeG.Bogner-Strauss:Funding

YEAR Agency Country:ProjectTitle(Number) Support(k€)2006-2012 FFG,

AustrianMinistryofScience

A:GOLDGenomicsofLipid-assosciatedDisorders 391

2010-2014 FWFandGraz

Universityof

Technology

A:Doktoratskolleg(Ph.D.excellenceprogram)MetabolicandCardiovascularDisease(DK-MCD):“Lipasesandadipogenesis”,1stfundingperiod

342

2011-2015 FWF A:TheroleofAPMAPinadipogenesisandenergymetabolism(standaloneproject)

355

2015-2017 FWF A:SFBLIPOTOX-AbhydrolaseDomainContaining15(ABHD15)–aKeyFactorinLipidMetabolismandApoptosis(3rdfundingperiod)

265

2014-2017 FWF A:Nat8l:anewplayerinbrownadiposetissuedevelopmentandenergymetabolism(standaloneproject)

350

2014-2018 FWFandGraz

Universityof

Technology

A:Doktoratskolleg(Ph.D.excellenceprogram)MetabolicandCardiovascularDisease(DK-MCD):“Whiteandbrownfatcelldevelopmentandenergymetabolsim”,2ndfundingperiod

350

2006-2016 2.053


APPENDIX3

TobiasEISENBERG.Fundingasleadapplicant:

YEAR Agency Country:ProjectTitle(Number) Support(k€)2013-2016 ÖAW Acetyl-CoAregulatesautophagy&aging(APART

program/11590)215

2013-2016 215


APPENDIX3

WolfgangF.GRAIER:Fundingasleadapplicant:

YEAR Agency Country:ProjectTitle(Number) Support(k€)1991-1992 ÖNB A:Diabetic-inducedendotheialdysfunction 70

1992 FWF A:PhysiologyandPathophysiologyofenothelialandsmoothmuscleionchannels(J0766)

23

1993-1994 ÖNB A:Diabeticvascularstress 621993-1994 EC EC:VascularDysfunction 321994-1996 FWF A:(Patho-)Physiologyandimportanceofendothelial

ionchannels(P10029)263

1995 EC EC:PharmacologyExperts 21995-1996 ÖNB A:Mechanismofendothelialdysfunctionindiabetes 701996-1999 Kamillo CH:VitaminEonPlatelets 271996-1998 ServierInt. F:MechanismsofendothelialDysfunction1 3001996-1997 FWF A:Physiologyandpathophysiologofendothelialion

regulationanditscontributiontoendothelialvascularfunction(P12306)

312

1997-2000 FWF A:PhysiologyandPathophysiologyofsubplasmalemmalCa2+storesandasuperficialbufferbarrierinendothelialcells(P12341)

352

1998-2001 FWF A:ContributionofglycatedLDLtochangesinsubcellularCa2+signaling,vasoactivityandgeneexpressionofsmoothmusclecellsindiabetesmellitusandhypercholesterolemia(SFB714/1)

276

1999-2002 ServierInt. F:MechanismsofendothelialDysfunction2 3001999-2000 HeartFund A:Diabetic-inducedmuscledysfunction 302000-2003 FWF A:SpatiotemporalCalciumSignalinginthe

Endothelium(P14586)351

2001-2005 FWF A:MolecularMechanismsofDiabetes-inducedVascularDysfunction:Theroleofthecellularhomologueofc-src,ß-cateninandthesmallGTP-bindingProteinRhoA(SFB714/2)

234

2003-2006 Ministry A:InstitutesofBasicMedicalSceinces 1.4002003-2007 FWF A:OrganelleCalciumFunctioninEndothelialCells

(P16860)373

2004-2007 ServierInt. F:EndothelialCa2+Homeostasis 2702007-2010 FWF A:LIPOTOX,Part10:Mitochondria,instigators

and/ortargetsoflipotoxicity?(SFBF30-B05)323

2008-2011 ServierInt. F:MechanismsofendothelialDysfunction 2002009-2012 FWF A:Anandamide/LPIsignalingandfunctionin

endothelialcells(P21857)317

2010-2014 FWF A:DoctoralCollegeofMetabolic&CardiovasculardiseaseI(W1226-B18)

136

2012-2014 ServierInt. F:MechanismsofmitochondrialDysfunction 2802013 ServierInt. F:SRleakageinsmoothmusclecells 100

2015-2018 Ministry A/Jp:NIKON-CenterofExcellence,Graz 2.0002015-2017 RedBull A:EnergySensing 1202015-2018 FWF A:DoctoralCollegeofMetabolic&Cardiovascular

diseaseI(W1226-B18136

2015-2016 ServierInt. F:MechanismsofendothelialDysfunction 2001992-2016 8.559


APPENDIX3

GuenterHAEMMERLE:Fundingasleadapplicant:

YEAR Agency Country:ProjectTitle(Number) Support(k€)2008-2013 FWF A:RoleofCGI-58inlipidandenergymetabolism

(P20602)299

2010-2018 FWF A:MetabolicandCardiovascularDisease(DK-MCDW1226)

392

2012-2016 FWF A:TheroleofCGI-58andnovelenzymesinepidermallipidmetabolismandbarrierformation(P24944)

349

2016-2019 FWF A:Perilipin5inbridginglipolysistoenergycatabolism(P29253)

349

2007- 1.389


APPENDIX3

TobiasMADL:Fundingasleadapplicant:

YEAR Agency Country:ProjectTitle(Number) Support(k€)2016–2019 FWF StructuralStudiesoftheß-CateninDestruction

Complex 349

2014 Dept.Chemie,TUM

CharacterizationofresidualstructureinthedisorderedAxin-1tumorsuppressorprotein 50

2013 BayIntAn Dissectingthecomplexmechanismsoftranscriptionfactoractivation 2

2012–2016 DFG Decipheringtheregulatorycodeoftranscription 9922012–2016 BioSysNet OrdertoProteinDisorder 1.485

2012(terminated

duetoEmmy

Noether)

ÖAW ExploringthemolecularbasisforFOXO’stumorsuppressivepotential

273

2008–2010 EMBO Quaternarystructureof3'splicesiterecognition 922008

(terminateddueto

EMBO-LTF)

FWF Quaternarystructureof3'splicesiterecognitionduringspliceosomeassembly 85

2005-2007 ÖAW StructuralInvestigationofabacterialtoxin/antitoxinsystem 50

2005-2016 3.293


APPENDIX3

RolandMALLI:Fundingasleadapplicant:


2011-2014 FWFSolvingamystery:mitochondrialcontributiontotheSTIM1/Orai1-dependentstore-operatedCa2+entry(P22553)

399

2016-2018 FWF TheEnergySupplyoftheEndoplasmicReticulum(P28529) 336

2011-2016 735


APPENDIX3

MartinPICHLER:Fundingasleadapplicant:


2004 H.B.MoserFoundation

A:Chimerismintransplantedheart 4.5

2005 H.B.MoserFoundation

A:Originoffibrosisintransplantedheart 4.5

2009-2012 MUGStart A:IDENTIFICATIONOFDIFFERENTIALLYEXPRESSEDMICRORNAsASPOTENTIALNOVELDRUGTARGETSBYTREATMENTOFCOLORECTALCANCERCELLSWITHTHEBRAF-INHIBITORSORAFENIB

85

2010-2012 StyrianGov. A:RoleofmicroRNAsofthewntpathwayinbiliarytractcancer

3

2010-2013 H.B.MoserFoundation

A:FunctionaleffectsonmyocardiumandinfluenceoncardiacmicroRNAexpressioninducedbythecancertherapeuticagentsunitinib

6.3

2012-2016 ÖNB A:Identificationofbreastcancerstemcell-associatednon-codingultraconservedgenesandtheirclinicalrelevance

150

2013-2015 FWF A:Roleofnon-codingRNAsincolorectalcancermetastases

80

2013-2014 CancerUnion,

DivisionofOncology

A:Non-codingRNAsinColorectalCancer 10

2013 ResearchgrantPierre

Fabre

Inflammationbasedbiomarkersinurothelialcarcinoma

10

2014-2015 Pfizerresearchgrant

A:RoleofmicroRNAsinCDK4/6inhibitorsresistance 10

2013-2014 StyrianCancer

Foundation

A:Roleofnon-codingRNAsincancerstemcellsofhepatocellularcarcinoma

25

2016 CancerUnion,

DivisionofOncology

A:RNAsequencingoftranscriptomeaftersilencingoflongnon-codingRNATSA-LncRNA1

6

2015-2016 Pfizerresearchgrant

A:RoleofmicroRNA1287inbreastcancer 10

2004-2016 404


APPENDIX3

WolfgangSATTLER:Fundingasleadapplicant:


1991-1992 FWF A:LOX-modifiedLDLinatherogenesis(J0776) 23

1994-1997 FWF A:SelectiveHDLcholesterylesteruptake(P10145) 69

1997-1999 ÖNB A:SteroidhormonesynthesisfromHDLlipids(6232) 22

1997-2000 FWF A:Tocopheroluptake(P12000) 174

1999-2000 ÖNB A:Tocopheroluptakeinmicroglia((8127) 263

2000-2004 FWF Tocopheroluptakeinthebrain(P14109) 295

2001-2005 FWF HDLattheblood-brainbarrier(SFB716) 210

2002-2004 ÖNB AntiinflammatorypropertiesofHDL(9622) 88

2004-2006 BMBWK Animprovedmodeloftheblood-brainbarrier(GZ80.100/2) 73

2006-2008 FFG PKDinbraintumors(810994) 128

2007-2014 FWF MPO-mediatedlipotoxicityinthebrain(SFB3007) 1.010

2009-2012 FFG PKDinglioma(820107) 343

2011-2014 ÖNB 25OH-Cholesterolastranscriptionalregulator(14534) 96

2012-2020 FWF/MUG MolecularFundamentalsofInflammation(DKMOLIN,W1241) 610

1991-2016 3.404


APPENDIX3

MichaelR.SPEICHER:Fundingasleadapplicant:

YEAR Agency Country:ProjectTitle(Number) Support(k€)1994-1996 DFG GER:Post-DocTrainingStipend(Sp460/1-1) 551997-2001 DFG GER:FurtherdevelopmentofMultiplex

Fluorescenceinsituhybridization(M-FISH)forapplicationsinbasicresearchandclinicalsettings(Sp460/2-1+Sp460/2-3)

142

1998-2000 DFG GER:Applicationofaonmulti-Fluorbased“TelomereAssay”forcomparativetopologyanddiagnosticapplications(Sp460/3-1)

83

2001-2003 DFG Novel,basedonmulticolor-fluorescenceinsituhybridizationstrategiesfortheanalysesofcrypticaberrationsinsubtelomericregionsofchromosomes(Sp460/4-1)

111

2003-2006 DFG GER:Newmolecularcytogeneticapproachesfortheanalysisofaneuploidyinearlystageurothelialcarcinoma(Sp460/5-1)

189

2003-2007 DFG GER:Three-dimensionalanalysesofchromosomeorganizationinnucleiofcyclinganddifferentiatedcellsinhumansandmice(CR59/20-3)

143

1997-1999 AlfriedKruppvonBohlenundHalbachStiftung

GER:Improvingthediagnosticsofcancer 60

1998-2002 GIF GER-Israel:ComparisonofthethreedimensionalchromatindistributioninnormalandtumorcellnucleibymultifluorFISH(G-491-112.9/1996)

93

2000-2003 SanderStiftung

GER:Analysesofprimarytumorandmetastasizedrenalcellcarcinomacellsfortheidentificationofprognosticandpredictivemarkers(2000.015.1)

70

2001-2003 SanderStiftung

GER:3Dkaryotypinginnucleiofcoloncarcinomaandcolonadenomaincomparisonwithnormalcolonepithelium(2001.079.1)

281

1999-2003 DeutscheKrebshilfe

GER:Comparativemolecularcytogeneticanalysesregardingthemalignantandbenigndisseminationofepithelialtumorcells(10-1392-PaI)

123


GER:High-resolutionmolecularcytogeneticcharacterizationofdisseminatedbreastcancercellsdependingontheirproliferativepotential(102319/10-2181-Pa2)

117


GER:High-resolutioncharacterizationofnovel,afterCD40Lstimulationidentifiedchromosomeaberrationsandinvolvedgenesinchroniclymphocyticleukemia(106424)

149

2001-2004 BMBF GER:Nationalgenomeresearchnet(1stphase/NGFN1)

1.055

2005-2007 BMBF GER:Nationalgenomeresearchnet(2ndphase/NGFN2)

327

2007-2009 ÖNB A:Characterizationofchangesinmedullarythyroidcarcinomagenomes(12569)

75

2013-2015 ÖNB A:MonitoringofpatientswithcolorectalcancerbyserialplasmaDNAanalyses(15093)

150

2008-2011 FWF A:Chromosomalinstabilityinagingandcancer 251


APPENDIX3

(P20338)2010-2014 FWF A:DoctoralCollegeofMetabolic&Cardiovascular

diseaseI(W1226-B18)136

2011-2014 FWF A:Applicationofhigh-resolutionsingle-celltechnologiestoCTCsforanin-depthcharacterizationoftheCTCgenome(P23284)

275

2010-2012 BMVIT,FFG,SFG

ONCOTYROL:Mutationspectrumincirculatingtumorcellsofpatientswithbreastorprostatecancer

400

2015-2017 FFG-Bridge A:Liquidbiopsydataanalysis(850700) 1062015-2017 FFG A:DRUID:Decision-supportforRare&Undiagnosed

InheritedDiseases35

2004-2009 EU-FP6 DISMAL:Molecularsignaturesasdiagnosticandtherapeutictargetsfordisseminatedepithelialmalignancies(LSHC-CT-2005-018911)

150

2008-2010 EU-FP7 GENINCA(GENomicINstabilityinCancer)(HEALTH-F2-2008-202230)

288

2015-2019 IMIJointUndertaking

EU:Cancer-ID(ContractNo.115749) 577

2014-2017 Janssen A:CharacterizationofprostatecancergenomesfromcirculatingtumorDNA

175

1994-2016 5.616

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Mitochondria – ER rewiring as instigator or backer of aging & cancer › fileadmin › institute-oes › ... · 2016-07-05 · LIST of APPENDICES: Mitochondria – ER rewiring as