Molecular and Biomedical Sciences at the University of Nebraska-Lincoln

Areas of Strength at UNL

MicrobiologyVirologyBacteriology

Redox BiologyBiochemistry

Vet Biomedicine

MICROBIOLOGY at UNL

HIVHSVEBVKSHVVSVPRRSVHPVBacteriaFungi

Funded by NIH Grant Number P20 RR15635 from theCOBRE Program of the National Center for ResearchResources

Anisa Angeletti Herpesvirus replication and host shutoffPeter Angeletti Human papillomavirus replicationRoy French Molecular biology of wheat virus diseasesClinton Jones Latency of alpha-herpesviruses, apoptosisEugene Martin Extreme halophiles, cyanophagesJack Morris Plant virology and biotechnologyFernando Osorio Animal virus pathogenesisAsit Pattnaik Gene expression of RNA virusesJames VanEtten Molecular characterization of algal virusesRobert Weldon Retrovirus assembly & pathogenesisCharles Wood HIV & herpesvirus molecular pathogenesisLuwen Zhang Herpes virus latency; interferonTom Petro Theilers Virus

Nebraska Center for Virology

40 Members on 3 campuses

UNL

Funded by Grant P20RR15635 from the COBRE of the National Center for Research Resources$10,950,000/ 5yrs (2005-2010)

Extramural Funding by NCV members since year 2000 Over 39 million (PHS funding) since incept.

NIH Graduate Student and Postdoc Training Grant T32 - Training grant in Virology (UNL)

Fogarty International Training Grant $2, 100,000

New Virology Building

Groundbreaking October 4th, 2006

Ken Morrison Research Building

What’s Going on in the Beadle Center?

In the Beadle Center

BiologyNebraska Center for VirologyBiochemistryCenter for Redox BiologyPlant ScienceBiotech Center

Dr. James Alfano Dr. Marjorie LouDr. Ruma Banerjee Dr. Stephen RagsdaleDr. Joseph Barycki Dr. Ashraf RazaDr. Donald Becker Dr. George RozanskiDr. Liang-cheng Du Dr. Harold SchultzDr. Howard Gendelman Dr. Greg SomervilleDr. Vadim Gladyshev Dr. Julie StoneDr. Jonathan Kipnis Dr. Mark ThomasDr. Jaekwon Lee Dr. Mark WilsonDr. Ming-Fong Lin

Microscopy Core Facility

Dr. Joe Zhou, Director

• microscopy imaging systems • technical support in bio-imaging • state-of-the-art equipment

three new electron microscopesa BioRad MRC1024ES confocal laser scanning microscopetwo advanced fluorescence microscopes with video

Biosafety Level 3 Facilities

Live HIV and other virus studies

East Campus

Soon to be commissioned

Beadle Center

Ken Morrison Building

Future

Flow Cytometry

Danielle Shea

Director: Dr. Charles Kuszynski

Beadle

East Campus

2 Locations:

Facscalibur

Bead-Array

UNL Genomics Facility

Gene-chipsDNA SequencingHybridization

Structural/Protein Core UNL Department of Chemistry Director: Dr. Ronald Cerny

• Exact Mass Measurement – Electron Ionization MS• Low Resolution Fast Atom Bombardment (FAB) MS• Exact Mass Measurement – FAB MS• Direct Injection (single component) Electrospray Ionization (ESI)• Liquid Chromatography – Mass Spectrometry (LC/MS)• Matrix Assisted Laser Desorption Ionization MS (MALDI) Peptide

Chrystallography Core

H. Moriyama

VBMSBiomedical Sciences (Animals and Humans)

Epidemiology

Bacteriology

Virology

Cell Biology

Parasitology

ToxicologyBarletta, Raul Duhamel, Gerald E., Jones, Clinton J.Lou, Marjorie F.Moxley, Rodney A.Osorio, Fernando A.Pattnaik, Asit K., Somerville, Greg,

Herpesvirus

PRRSV

Bacterial Path

Etsuko MoriyamaSteve Ladunga

Computer Science Mike Fromm

Pesticide Absorption into the BodyFuzzy Modeling of Skin Permeability CoefficientsTransdermal Delivery of Antisense Oligonucleotides Biosignals & SystemsMedical ImagingBiomedical imagingNoninvasive blood flow velocity measurementSingle molecule imaging and trackingDNA sequencing instrumentation

The Future at UNL?

Areas of Collaboration?Cross-field: Nanotechnology and molecular biology, Computer modelling; complex systemsMicrobiology of pathogens, drug and vaccine development (Strong Chemistry and Animal Sciences).

Multidisciplinary Cross-department, Cross-campusCollaborations. More Growth in Funding (despite recent NIH budget dips).Unique Niches.