LIFE SCIENCE 2018

2nd Joint Annual Symposium 20-21-22 June 2018 - Aula F, Campus Aquae

20thJUNE13:45-14:00Gree,ngsfromtheRectoroftheUniversityofPavia

Figh&ngdiseases:dissec&ngthemolecularmechanisms(Chairpersonprof.Alber&niA.)1.14:00-14:15Cancercellmetabolism:theglutamine-asparagineconnec,on(MondelloC,IGM-CCNR)2.14:15-14:30Sporadicandhereditarygastriccancer:CDH1(E-cadherin)geneandbeyond(RanzaniGN,DBB)3.14:30-14:45Expandingthespectrumofclinicalphenotypes:fromgenetodiseaseandback(ErrichielloE,DMM)4.14:45-15:00Ataleofsomeofthe“twobrains”pathologies(CominciniS,DBB)5.15:00-15:15Exploi,ngRNaseH2ac,vitytowardsuncanonicalsubstratesgeometry(CrespanE,IGM-CNR)6.15:15-15:30AdamagedDNAbindingprotein2(DDB2)muta,ondisrup,nginterac,onwithPCNAaffectsDNA

repairandconfersprolifera,onadvantage(GuardamagnaI,DMM)7.15:30-15:45TheRNAprocessingfactorsDICERandDROSHAcontrolchroma,nconforma,onandgene

transcrip,onatDNAdouble-strandbreaksites(CapozzoI,IGM-CNR)8.15:45-16:00Doyouknowwhat’sinyourlaboratorywater?Theimpactofwaterqualityonyourexperiments

(RichéE.,Merck)16:00-16:30CoffeebreakTHESYMPOSIUMMOVESTOROOMA4(CAMPUS)9.16:30-17:30Invitedspeaker:Howplaceboeffectsinfluenceclinicaloutcomes(CollocaL,Univ.Maryland,USA)

21stJUNEFigh&ngdiseases:dissec&ngthemolecularmechanisms(Chairpersonprof.Biamon&G.)10.9:00-9:15Larvaldietimpactsmalepheromonecomposi,oninthemedflyCera,,scapitata(ScolariF,DBB)11.9:15-9:30NonretroviralintegratedRNAvirusesinthegenomeofmosquitovectors:anewformofimmunity?

(Pala,niU,DBB)12.9:30-9:45TSPYL2isanovelregulatorofSIRT1andp300ac,vityinresponsetoDNAdamage

(Zannini,IGM-CNR)13.9:45-10:00LSD2-NPAC:nucleosomerecogni,onandheterochroma,niza,onprocesses(PilofoS,DBB)14.10:00-10:15Nova2drivestheforma,onofspecificbloodvesselsthroughtheproduc,onofanovelalterna,ve

splicingisoformofthedependencereceptorUnc5b(PradellaD,IGM-CNR)15.10:15-10:30PTPRD:acandidategeneforintellectualdisabilityandneurodevelopmentaldisorders(TuveriS,DMM)16.10:30-10:45Mechanismsthatrescuereplica,onforksarrestedbytranscrip,on(ZardoniL,IGM-CNR)17.10:45-11:00Behindenemylines:thegastricmucosalbarrierandwarstrategiesinsidehumanstomach

(RicciV,DMM)11:00-11:30Coffeebreak18.11:30-11:45Moleculararchitectureofthemul,func,onalenzymeLH3,acollagenlysylhydroxylaseand

glycosyltransferase(ScieiL,DBB)19.11:45-12:00Screeningofcircula,ngmiRNAsinHereditaryHemorrhagicTelangiectasia:differencesbetween

HHT1andHHT2pa,entsandinvolvementofangiomiRs(PlumitalloS,DMM)20.12:00-12:15Signallingpathwaysdis,nc,veoftrichothiodystrophyorxerodermapigmentosum

(LombardiA,IGM-CNR)21.12:15-12:30Figh,ngtheeffectsofdamagingenvironmentalcuesonwomenfer,lityandembryonic

development(CavaleraF,CivelloC,DBB)22.12:30-12:45Rescuingthecor,costriatalsynap,cimpairmentsintwomousemodelsofHun,ngton’sDisease

(HD)(TalpoF,DBB)

2nd Joint Annual Symposium

22ndJUNEGene&cvariabilityinbasicandclinicalsciences(Chairpersonprof.BoVnelliR.)35.9:00-9:15Ancientandmoderngenomes:newapproachesandtoolstoreconstructthegene,chistoryof

humanpopula,ons(RaveaneA,CapodiferroMR,DBB)36.9:15-9:30Chromothripsis:evolu,onofdenovosmallsupernumerarymarkerchromosomesfromtrisomies

(KurtasN,DMM)37.9:30-9:45MicroRNAsignatures:bridgingpathwaysbetweenplantsandanimals(MacoveiA,DBB)38.9:45-10:001.Inves,ga,ngtheFunc,onofTelomericRepeat-containingRNA;2.SatelliteDNAisresponsible

forcentromereclusteringinmammals(DelGiudiceS,CappelleiE,DBB)39.10:00-10:15Theepigene,clandscapeofmammaliancentromeres(CorboM,Rober,A,DBB)

Bridgingbasicresearchandbiotechnologicalapplica&ons(Chairpersonprof.BoVnelliR.)40.10:15-10:30Probingthefunc,onofproteinsintheAedesalbopictussaliva(GabrieliPDBB)41.10:30-10:45Mul,-channelsilkspongeforbio-engineeringthehumanbonemarrowenvironment:anewtoolfor

func,onalplateletproduc,onexvivo(DiBuduoCA,DMM)10:45-11:15Coffeebreak42.11:15-11:30MicrobialBiotechnology(LonganesiL,DBB)43.11:30-11:45Nanotechnologyapplica,onsforinnova,vetherapeu,capproaches(BloiseN,DMM)44.11:45-12:00Compara,vedistribu,onof5mC/5hmConDNAandRNAatEMlevel(SicilianiS,DBB)45.12:00-12:15Invitroandinvivocharacteriza,onofthestericgateresidueofDNApolymeraseh(MaffiaA,CNR)46.12:15-12:30Sustainablerecyclingofvegetableandfruitwastestorecoverphytochemicalswithnutraceu,cal

and/orcosmeceu,calproper,es(DoriaE,DBB)47.12:30-13:00ThenewCGS2‘MolecularandCellMicroscopyFacility’(FrecceroM,Delegatoperleinfrastrufure

dellaricerca)

21stJUNEFigh&ngdiseases:developingnewtherapies(Chairpersonprof.GherardiE.)23.14:00-14:15Acommonmolecularmechanismforbiologicalclocksanddegenera,vediseases

(DamianiG,IGM-CNR)24.14:15-14:30Newcompoundsandnewapproachestofightinfec,ousdiseases(BuroniS,DBB)25.14:30-14:45Visualiza,onofintactneuroimmunegatewaysinaclarifiedbrainstem-innerearprepara,onforthe

studyofauditorysystemneuroinflammatoryresponses(PerinP,DMM)26.14:45-15:00Humanpluripotentstemcellstowardsstriatalmediumspinyneuronsinphysiologyandpathology:

anelectrophysiologicalpointofview(ManiezziC,DBB)27.15:00-15:154-PBAamelioratescellularhomeostasisinfibroblastsfromosteogenesisimperfectapa,ent

(BesioR,DMM)28.15:15-15:30Genewiz15:30-16:00Coffeebreak29.16:00-16:15Characteriza,onofnovelneuroprotec,vefunc,onsofPINK1,mutatedinautosomalrecessive

ParkinsonDisease,inmodula,ngmitophagyandaggrephagy(ValenteEM,DMM)30.16:15-16:30Prognos,cevalua,onstailoredtospecificgastricneuroendocrineneoplasms.Analysisof200cases

withextendedfollow-up(VanoliA,DMM)31.16:30-16:45LysosomalCa2+signallingcontrolsprolifara,onandmigra,oninhumanprimaryculturesof

colorectalcancer(PawanF,DBB)32.16:45-17:00Clinico-pathologicandmolecularstudyonanovelsubsetofmantlecelllymphoma,characterized

byaMALT-typepresenta,onandindolentbehavior(Fra,celliS,DMM)33.17:00-17:15Plateletamyloidprecursorproteinisaregulatorofvenousthromboembolisminmice

(VisconteC,DBB)34.17:15-17:30Effectsofthenewcispla,n-basedPt(IV)Ac-POAprodruginB50andC6ratcells(FerrariB,DBB)

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LIFE SCIENCE 2018 2nd Joint Annual Symposium of the Departments of Biology and Biotechnology,

Molecular Medicine and CNR Institute of Molecular Genetics

University of Pavia, 20-21-22 June 2018

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